KR101591015B1 - Orthodontic coating composition and method for preparing same - Google Patents

Orthodontic coating composition and method for preparing same Download PDF

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Publication number
KR101591015B1
KR101591015B1 KR1020150100987A KR20150100987A KR101591015B1 KR 101591015 B1 KR101591015 B1 KR 101591015B1 KR 1020150100987 A KR1020150100987 A KR 1020150100987A KR 20150100987 A KR20150100987 A KR 20150100987A KR 101591015 B1 KR101591015 B1 KR 101591015B1
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water
coating composition
orthodontic
weight
fatty acid
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KR1020150100987A
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Korean (ko)
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오명환
김윤기
김태경
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(주) 베리콤
김태경
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Priority to PCT/KR2016/005054 priority patent/WO2017010667A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/12Brackets; Arch wires; Combinations thereof; Accessories therefor
    • A61C7/14Brackets; Fixing brackets to teeth
    • A61C7/16Brackets; Fixing brackets to teeth specially adapted to be cemented to teeth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/12Brackets; Arch wires; Combinations thereof; Accessories therefor
    • A61C7/28Securing arch wire to bracket
    • A61C7/282Buccal tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/12Brackets; Arch wires; Combinations thereof; Accessories therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/12Brackets; Arch wires; Combinations thereof; Accessories therefor
    • A61C7/20Arch wires

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  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dental Preparations (AREA)

Abstract

The present invention relates to a water-soluble or biodegradable polymer; And at least one selected from the group consisting of ethanol and water, and is coated on the orthodontic wire to provide an orthodontic coating composition. Thus, the coating composition for orthodontic treatment of the present invention can be easily applied to teeth by coating on wires after water-soluble or biodegradable.

Description

TECHNICAL FIELD [0001] The present invention relates to a coating composition for orthodontics,

The present invention relates to a coating composition for orthodontic treatment and a method of manufacturing the same, and more particularly, to a coating composition for orthodontic treatment which can easily perform orthodontic treatment by directly applying a coating composition for orthodontic treatment to a wire, To compositions and methods of making the same.

Orthodontic treatment is called "malocclusion" when the teeth are not aligned or the up and down engagement is out of the normal range. In the case of malocclusion, various orthodontic appliances are used to catch malocclusion because they are not only not good for viewing, but also impair pronunciation and chewing function.

The most typical of these is the bracket, which can be used with orthodontic wires to move teeth. The bracket basically has the function of guiding the tooth to slide along the wire while continuously transmitting the restoring force generated by the warped wire in the shape of a crooked tooth to the tooth.

However, the brackets are very uncomfortable due to the relatively large and complicated structure, and the brackets are visible during treatment, resulting in a loss of aesthetics.

In order to overcome such disadvantages, an orthodontic method using a mini tube and a wire in the form of a small hollow tube is also used. Such a procedure is described in Korean Patent No. 1,234,205 'Orthodontic Therapy Tubes'.

However, the orthodontic method using a mini tube has the following fundamental problems.

First, it is very difficult to insert a wire into a mini tube having a small inner diameter of about 0.5 mm attached to irregularly crooked teeth in the oral cavity.

Second, because it is fundamentally impossible to insert a wire from the back of the neck, the mini tube can not be used for posterior teeth (molar teeth) and can only be used for partial orthodontic treatment, which is practically limited to the anterior teeth (front teeth).

Therefore, it is necessary to develop a simple and universal method that can perform orthodontic treatment in the posterior part while minimizing patient inconvenience.

It is an object of the present invention to provide a coating composition for orthodontics and a method for manufacturing a coating composition for orthodontics which can easily perform tooth orthodontic treatment by directly coating a water-soluble or biodegradable coating composition on a tooth for orthodontic wire and adhering to a tooth have.

According to an aspect of the present invention,

Water-soluble or biodegradable polymers; And at least one selected from the group consisting of ethanol and water, and is coated on the orthodontic wire to provide an orthodontic coating composition.

Wherein the coating composition for orthodontic treatment comprises 10 to 100 parts by weight of a water-soluble or biodegradable polymer; And 20 to 990 parts by weight of at least one selected from ethanol and water.

The orthodontic coating composition may further include a compound represented by the following formula (1).

[Chemical Formula 1]

Figure 112015068912499-pat00001

In Formula 1,

n is an integer of 1 to 8;

The coating composition for orthodontics may further comprise 0.1 to 20 parts by weight of the compound represented by the formula (1).

The orthodontic coating composition may further comprise 0.1 to 5 parts by weight of a surfactant.

Wherein the water soluble or biodegradable polymer is selected from the group consisting of polyvinyl alcohol, gelatin, starch, cellulose, vegetable gum, modified starch, modified cellulose, carboxymethyl starch, hydroxymethyl cellulose, carboxymethyl cellulose, acrylamide, hydrolyzable polyacrylamide , Polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, polypropylene glycol, biodegradable polyamide, biodegradable polyurethane, and biodegradable polyester.

The water-soluble or biodegradable polymer may include polyvinyl alcohol.

The polyethylene glycol may be a solid having a molecular weight of 1,000 to 100,000.

The biodegradable polyamide may include at least one selected from polylactic acid and modified polylactic acid.

The water-soluble or biodegradable polymer may include at least one selected from modified starch and vegetable gum.

The compound represented by Formula 1 may include at least one selected from xylitol, sorbitol, and glycerin.

Wherein the surfactant comprises at least one selected from the group consisting of polyethylene glycol, polysorbate, fatty acid monoglycerin ester, fatty acid polyglycol ester, fatty acid sorbitan ester, fatty acid sucrose ester, fatty acid alkanolamide and polyethylene glycol condensation type nonionic surfactant can do.

Wherein the coating composition for orthodontics comprises 100 parts by weight of polyvinyl alcohol; 20 to 900 parts by weight of water; 1 to 5 parts by weight of xylitol; And 1 to 10 parts by weight of sorbitol.

The orthodontic coating composition may further comprise 0.1 to 5 parts by weight of a surfactant.

According to another aspect of the present invention,

Water-soluble or biodegradable polymers; And at least one selected from the group consisting of ethanol and water (step a).

Step a can be carried out at 20 to 80 占 폚.

The water-soluble or biodegradable polymer may include polyvinyl alcohol.

(A ') mixing the compound represented by the formula (1) below.

[Chemical Formula 1]

Figure 112015068912499-pat00002

In Formula 1,

n is an integer of 1 to 8;

The compound represented by Formula 1 may include at least one selected from xylitol, sorbitol, and glycerin.

Step a " may comprise mixing the surfactant (step a ").

Wherein the surfactant comprises at least one selected from the group consisting of polyethylene glycol, polysorbate, fatty acid monoglycerin ester, fatty acid polyglycol ester, fatty acid sorbitan ester, fatty acid sucrose ester, fatty acid alkanolamide and polyethylene glycol condensation type nonionic surfactant can do.

According to another aspect of the present invention,

Water-soluble or biodegradable polymers; And at least one selected from ethanol and water to prepare a coating composition for orthodontic treatment (step 1); And coating and drying the coating composition for orthodontic treatment on a wire to prepare an orthodontic complex (step 2).

According to the present invention, there is provided an effect of providing a coating composition for orthodontic treatment and a method of manufacturing a coating composition for orthodontic treatment which can easily perform orthodontic treatment by directly coating the orthodontic wire with a coating composition for orthodontic treatment have.

1 shows a clinical test procedure of orthodontic treatment using the dental orthodontic composite of the present invention.
Fig. 2 shows clinical test results of orthodontic treatment using the dental orthodontic composite of the present invention.
Fig. 3 shows the result of orthodontic correction using a conventional bracket.
FIG. 4 is a photograph of a conventional orthodontic tube using a hollow tube type tube.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily carry out the present invention.

However, the following description does not limit the present invention to specific embodiments. In the following description of the present invention, detailed description of related arts will be omitted if it is determined that the gist of the present invention may be blurred .

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In the present application, the terms "comprises ", or" having ", and the like, specify that the presence of stated features, integers, steps, operations, elements, or combinations thereof, But do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, or combinations thereof.

Hereinafter, the coating compositions for orthodontics of the present invention will be described.

The coating composition for orthodontic treatment of the present invention comprises a water-soluble or biodegradable polymer; And one or more selected from ethanol and water. In addition, the coating compositions for orthodontics can be coated on the orthodontic wire.

Preferably, the coating composition for orthodontic treatment comprises 10 to 100 parts by weight of a water-soluble or biodegradable polymer; And 20 to 990 parts by weight of at least one selected from ethanol and water.

The orthodontic coating composition may further comprise a compound represented by the following formula (1), and preferably 0.1 to 20 parts by weight of a compound represented by the following formula (1).

[Chemical Formula 1]

Figure 112015068912499-pat00003

In Formula 1,

n is an integer of 1 to 8;

The orthodontic coating composition may further comprise 0.1 to 5 parts by weight of a surfactant.

The orthodontic coating composition may be coated on a wire and dried.

The wire coated with the orthodontic coating composition is bonded to teeth using a resin at a crooked dental temperature. In a bent cantilevered wire, a restorative force is generated on the bonded wire, which is transferred to the tooth with a correcting force to move the tooth through the adhesive resin. At the same time, the coating composition for orthodontic treatment coated on the wire is soluble or biodegradable and melts in the oral cavity, so that a gap is formed between the wire and the resin, so that the tooth can slide and move along the wire.

The water-soluble or biodegradable polymer may be any substance that can be decomposed in the oral cavity. Preferred are polyvinyl alcohol, gelatin, starch, cellulose, vegetable gum, modified starch, modified cellulose, carboxymethyl starch, hydroxymethylcellulose, carboxymethylcellulose, acrylamide, hydrolyzable polyacrylamide, polyvinylpyrrolidone Polyvinyl alcohols, polyethylene glycols, polypropylene glycols, biodegradable polyamides, biodegradable polyurethanes and biodegradable polyesters.

More preferably, the water-soluble or biodegradable polymer may be polyvinyl alcohol.

The polyethylene glycol may be a solid phase having a molecular weight of 1,000 to 100,000.

The biodegradable polyamide may be polylactic acid, modified polylactic acid, or the like.

The water-soluble or biodegradable polymer may include modified starch and vegetable gum.

The compound represented by the above formula (1) may preferably be xylitol, sorbitol, and glycerin.

The surfactant may be polyethylene glycol, polysorbate, fatty acid monoglycerin ester, fatty acid polyglycol ester, fatty acid sorbitan ester, fatty acid sucrose ester, fatty acid alkanolamide, polyethylene glycol condensation type nonionic surfactant and the like.

The coating composition may preferably comprise 100 parts by weight of polyvinyl alcohol, 20 to 900 parts by weight of water, 1 to 5 parts by weight of xylitol, and 1 to 10 parts by weight of sorbitol.

In addition, the coating compositions for orthodontics may further comprise 0.1 to 5 parts by weight of a surfactant.

Hereinafter, a method for producing a coating composition for orthodontic treatment of the present invention will be described.

Water-soluble or biodegradable polymers; And one or more selected from ethanol and water (step a).

Step a can be carried out at 20 to 80 占 폚, preferably at 30 to 70 占 폚, more preferably at 40 to 60 占 폚.

The components of the orthodontic coating composition can be evenly mixed in the temperature range.

Step a is preferably carried out for 1 to 48 hours, but is not limited thereto. It may be varied depending on the execution temperature of step a.

The water-soluble or biodegradable polymer may preferably comprise polyvinyl alcohol.

Step a may further comprise the step of mixing the compound represented by the following formula (1) (step a ').

[Chemical Formula 1]

Figure 112015068912499-pat00004

In Formula 1,

n is an integer of 1 to 8;

The compound represented by Formula 1 is preferably xylitol, sorbitol, glycerin, or the like.

Step a may further comprise mixing the surfactant (step a "). In addition, the order of step a 'and step a' 'is not limited.

The surfactant may be polyethylene glycol, polysorbate, fatty acid monoglycerin ester, fatty acid polyglycol ester, fatty acid sorbitan ester, fatty acid sucrose ester, fatty acid alkanolamide, and polyethylene glycol condensation type nonionic surfactant.

Hereinafter, a method for producing the dental prosthesis composite of the present invention will be described.

First, a water-soluble or biodegradable polymer; And at least one selected from ethanol and water are mixed to prepare a coating composition for orthodontic treatment (Step 1).

Step 1 may be carried out at 20 to 80 ° C, preferably at 30 to 70 ° C, more preferably at 40 to 60 ° C.

Step 1 may be carried out for preferably 1 to 48 hours, but is not limited thereto. It may be varied depending on the execution temperature of step 1.

The water-soluble or biodegradable polymer may preferably comprise polyvinyl alcohol.

Finally, the orthodontic coating composition is coated on a wire and dried to prepare an orthodontic complex (Step 2).

Step 2 can be carried out at 20 to 80 캜, preferably at 30 to 60 캜, more preferably at 45 to 55 캜.

Step 2 can be carried out preferably for 1 minute to 10 minutes, but is not limited thereto. It may be varied depending on the execution temperature of step 2.

[Example]

Hereinafter, preferred embodiments of the present invention will be described. However, this is for illustrative purposes only, and thus the scope of the present invention is not limited thereto.

Example 1: Preparation of a coating composition for orthodontics

100 parts by weight of polyvinyl alcohol, 400 parts by weight of water and 1 part by weight of xylitol were mixed to prepare a coating composition for orthodontic correction.

Example 2: Preparation of coating compositions for orthodontics

50 parts by weight of polyvinylpyrridone, 50 parts by weight of polyethylene glycol, 400 parts by weight of ethanol, 1 part by weight of tween 80 and 1 part by weight of xylitol were mixed to prepare a coating composition for orthodontic correction.

Example 3: Preparation of a composite for orthodontics

The coating composition for orthodontic treatment according to Example 1 was coated on a portion of the wire to be subjected to the orthodontic treatment and then dried with dry air at 50 ° C for 5 minutes to prepare an orthodontic composite.

Example 4: Preparation of a dental orthodontic composite

The coating composition for orthodontic treatment according to Example 2 was coated on the portion of the wire to be subjected to the orthodontic treatment and then dried with dry air at 50 DEG C for 5 minutes to prepare an orthodontic composite.

[Test Example]

Clinical Test Example 1: Orthodontic correction using an orthodontic composite

The clinical test procedure of orthodontics using the dental orthodontic composite prepared according to Example 4 is shown in Fig. 1, and the results are shown in Fig.

Referring to Figures 1 and 2, the orthodontic composite prepared according to Example 4 was directly bonded to the teeth. As a result, it was possible to apply it to posterior teeth.

 Thus, it can be seen that the dental orthodontic composite prepared in Example 4 is aesthetically simple, has no soft tissue stimulation by the device, is comfortable, and can easily maintain oral hygiene.

Clinical Comparative Test Example 1: Orthodontic correction using a conventional bracket

The results of the orthodontic treatment using a conventional bracket are shown in Fig.

Referring to FIG. 3, after a conventional bracket is bonded to a tooth, the wire is bound so as not to be pulled out of the bracket by using a binding tie. As a result, brackets and their attachments with large and complicated structures were found to stimulate soft tissues in the oral cavity.

Therefore, it has been found that the conventional bracket is not aesthetic due to a complicated structure, stimulates the soft tissues in the oral cavity, and makes oral hygiene maintenance difficult.

Clinical Comparative Test Example 2: Orthodontic correction using hollow tube type tube

FIG. 4 shows a photograph of the orthodontic treatment using a conventional hollow tube type tube.

Referring to FIG. 4, a conventional tube-shaped tube is bonded to teeth, and then the wires are sequentially inserted. As a result, since it is fundamentally impossible to insert the wire from the back of the neck, it can be applied only to partial orthodontic treatment limited to the anterior part.

Therefore, it can be seen that the hollow tube type tube can be applied only to the partial orthodontic treatment limited to the anterior portion, and it takes much time to insert the wire.

The scope of the present invention is defined by the appended claims rather than the detailed description and all changes or modifications derived from the meaning and scope of the claims and their equivalents are to be construed as being included within the scope of the present invention do.

Claims (20)

Water-soluble or biodegradable polymers;
Ethanol and water; And
A compound represented by Formula 1 below; / RTI >
A coating composition for orthodontic use which is coated on an orthodontic wire.
[Chemical Formula 1]
Figure 112015120912498-pat00011

In Formula 1,
n is an integer of 1 to 8;
2. The composition of claim 1, wherein the coating composition for orthodontic treatment comprises
10 to 100 parts by weight of a water-soluble or biodegradable polymer; And
And 20 to 990 parts by weight of at least one selected from the group consisting of water, ethanol and water.
delete The method according to claim 1,
Wherein the coating composition for orthodontics further comprises 0.1 to 20 parts by weight of a compound represented by the formula (1).
The method according to claim 1,
Wherein said orthodontic coating composition further comprises 0.1 to 5 parts by weight of a surfactant.
The method according to claim 1,
Wherein the water soluble or biodegradable polymer is selected from the group consisting of polyvinyl alcohol, gelatin, starch, cellulose, vegetable gum, modified starch, modified cellulose, carboxymethyl starch, hydroxymethyl cellulose, carboxymethyl cellulose, acrylamide, hydrolyzable polyacrylamide , At least one selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, polypropylene glycol, biodegradable polyamide, biodegradable polyurethane and biodegradable polyester. / RTI >
The method according to claim 1,
Wherein the water-soluble or biodegradable polymer comprises polyvinyl alcohol.
The method according to claim 6,
Wherein the polyethylene glycol is a solid phase having a molecular weight of 1,000 to 100,000.
The method according to claim 6,
Wherein the biodegradable polyamide comprises at least one selected from polylactic acid and modified polylactic acid.
The method according to claim 1,
Wherein the water-soluble or biodegradable polymer comprises at least one selected from the group consisting of modified starch and vegetable gum.
The method according to claim 1,
Wherein the compound represented by Formula 1 comprises at least one selected from xylitol, sorbitol, and glycerin.
6. The method of claim 5,
Wherein the surfactant comprises at least one selected from the group consisting of polyethylene glycol, polysorbate, fatty acid monoglycerin ester, fatty acid polyglycol ester, fatty acid sorbitan ester, fatty acid sucrose ester, fatty acid alkanolamide and polyethylene glycol condensation type nonionic surfactant Wherein the coating composition for orthodontic treatment is a coating composition for orthodontic treatment.
The method according to claim 1,
Wherein the coating composition for orthodontic treatment comprises
100 parts by weight of polyvinyl alcohol;
20 to 900 parts by weight of water;
1 to 5 parts by weight of xylitol; And
1 to 10 parts by weight of sorbitol;
≪ / RTI >
Water-soluble or biodegradable polymers; And at least one selected from ethanol and water (step a); And
Mixing the resultant product of step a with a compound represented by the following formula (1) (step a ');
≪ / RTI >
[Chemical Formula 1]
Figure 112015120912498-pat00012

In Formula 1,
n is an integer of 1 to 8;
15. The method of claim 14,
Wherein step a is carried out at 20 to < RTI ID = 0.0 > 80 C. < / RTI >
delete 15. The method of claim 14,
Wherein the compound represented by Formula 1 comprises at least one selected from xylitol, sorbitol, and glycerin.
15. The method of claim 14,
≪ / RTI > wherein step a further comprises the step of mixing the surfactant (step a ").
19. The method of claim 18,
Wherein the surfactant comprises at least one selected from the group consisting of polyethylene glycol, polysorbate, fatty acid monoglycerin ester, fatty acid polyglycol ester, fatty acid sorbitan ester, fatty acid sucrose ester, fatty acid alkanolamide and polyethylene glycol condensation type nonionic surfactant ≪ / RTI > by weight of the composition.
Water-soluble or biodegradable polymers; And at least one selected from ethanol and water to prepare a coating composition for orthodontic treatment (step 1); And
(2) coating the wire coating composition on the wire and then drying the coated composition to prepare an orthodontic composite.
KR1020150100987A 2015-07-16 2015-07-16 Orthodontic coating composition and method for preparing same KR101591015B1 (en)

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PCT/KR2016/005054 WO2017010667A1 (en) 2015-07-16 2016-05-13 Water-soluble or biodegradable composition used for orthodontic member

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017010667A1 (en) * 2015-07-16 2017-01-19 (주) 베리콤 Water-soluble or biodegradable composition used for orthodontic member
WO2019108018A1 (en) * 2017-12-01 2019-06-06 오스템임플란트 주식회사 Orthodontic wire having multi-layer structure
WO2023063467A1 (en) * 2021-10-14 2023-04-20 이와이어라이너 주식회사 Orthodontic device and method for using orthodontic device
KR20230114014A (en) 2022-01-24 2023-08-01 주식회사 알케미 Biocompatible coating method for dental metal materials

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002003335A (en) * 2000-04-21 2002-01-09 Koden Kk Coating composition for cosmetic, removing agent therefor, and opened lips intraoral supporter
US20120199138A1 (en) * 2011-02-08 2012-08-09 Hannapel Eric D Orthodontic appliance shield
US20140302448A1 (en) * 2013-04-05 2014-10-09 Benjamin Cassalia Orthodontic Wire Alignment System and Method
KR20140138937A (en) * 2012-03-23 2014-12-04 호아킨 티. 아리자 Tube for orthodontics

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002003335A (en) * 2000-04-21 2002-01-09 Koden Kk Coating composition for cosmetic, removing agent therefor, and opened lips intraoral supporter
US20120199138A1 (en) * 2011-02-08 2012-08-09 Hannapel Eric D Orthodontic appliance shield
KR20140138937A (en) * 2012-03-23 2014-12-04 호아킨 티. 아리자 Tube for orthodontics
US20140302448A1 (en) * 2013-04-05 2014-10-09 Benjamin Cassalia Orthodontic Wire Alignment System and Method

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017010667A1 (en) * 2015-07-16 2017-01-19 (주) 베리콤 Water-soluble or biodegradable composition used for orthodontic member
WO2019108018A1 (en) * 2017-12-01 2019-06-06 오스템임플란트 주식회사 Orthodontic wire having multi-layer structure
WO2023063467A1 (en) * 2021-10-14 2023-04-20 이와이어라이너 주식회사 Orthodontic device and method for using orthodontic device
KR20230114014A (en) 2022-01-24 2023-08-01 주식회사 알케미 Biocompatible coating method for dental metal materials

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