KR101585301B1 - Device for transilluminating focused ultrasound to the biological tissue by using semi-rigid hydrogel and method of manufacturing thereof - Google Patents

Abstract

The present invention relates to a device using a semi-solid hydrated gel for allowing an ultrasonic wave generated from an intensive ultrasonic generator to be easily transferred to a living tissue without scattering when the intensive ultrasonic generator is used for a living tissue, and a manufacturing method thereof. An ultrasonic wave generator for generating ultrasonic waves to be transmitted to the living tissue, an applicator for fixing the position of the ultrasonic wave to the living tissue, the one side being connected to the ultrasonic wave generator and the opening being provided on the other side; An ultrasonic transducer positioned at an opening of the applicator and recessed in a direction toward the living tissue and transmitting ultrasound transmitted through the applicator to the living tissue using the concave lens shape; And a semi-solid hydrated gel positioned between the ultrasound transducer and the living tissue to support the delivery of the ultrasound to the living tissue, wherein the ultrasound transmitted to the living tissue is formed by a concave lens shape of the ultrasound transducer Wherein the semi-solid hydrated gel has flexibility and is deformed according to the external shape of the living tissue.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a device using a semi-solid hydrogel for transmitting intensive ultrasound to living tissues, and a method of manufacturing the same. [0002]

The present invention relates to a device using a semi-solid hydrated gel for allowing an ultrasonic wave generated from an intensive ultrasonic generator to be easily transferred to a living tissue without scattering when the intensive ultrasonic generator is used for a living tissue, and a manufacturing method thereof.

Ultrasound refers to a sound wave having a frequency over the human audible frequency band, and is used in various medical diagnoses.

As an example, intensive ultrasound, which is used for non-invasive heating and necrosis of tumor tissue or for focusing ultrasound energy at the focus of delivery, is transmitted to the brain or peripheral nerve tissue, Is used in a way to control.

When the ultrasound transducer is used in the human body, a space may be formed between the device and the skin of the human body. Therefore, in order to fill the space, ultrasound waves can not penetrate through the space, This is a method of immersing the filled bag or the human body in water with air removed.

In recent years, a method of filling a space using a hydrogel similar to human or water properties has been developed in order to eliminate such inconvenience. However, a retainer made of a solid body surrounding a hydrogel or a hydrogel has an ultrasonic focus It is difficult to adjust the depth of the ultrasonic focus because the skin is hardly contacted when donating into the human body. To do this, various kinds of water gel and receiver must be prepared. Therefore, a new hydration gel and intensive ultrasonic generator It is necessary.

Patent Registration No. KR101143645 B1 Patent Registration No. KR101190910 B1 United States Patent Application Publication No. US20040234453 A1

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art, and an object of the present invention is to provide a water- And to provide a user with an intensive ultrasonic generator that moves freely regardless of the up, down, left, and right angles.

It is to be understood that both the foregoing general description and the following detailed description of the present invention are exemplary and explanatory and are not intended to limit the invention to the precise form disclosed. It can be understood.

According to another aspect of the present invention, there is provided an intensive ultrasonic generator including: an ultrasonic generator for generating ultrasonic waves to be transmitted to a living tissue; one side connected to the ultrasonic generator and an opening provided on the other side; An ultrasonic wave transmitting unit for transmitting ultrasonic waves transmitted through the applicator to the living body tissue using the concave lens shape; An ultrasonic transducer for transmitting the ultrasonic wave to the living tissue; And a semi-solid hydrated gel positioned between the ultrasound transducer and the living tissue to support the delivery of the ultrasound to the living tissue, wherein the ultrasound transmitted to the living tissue is formed by a concave lens shape of the ultrasound transducer And the semi-solid hydrated gel is flexible and can be deformed according to the external shape of the living tissue.

In addition, the semi-solid hydrated gel may be composed of PVA that is hydrophilic so that it does not stimulate the human body.

Further, the semi-solid hydrated gel can be produced by repeating freezing and thawing of the solution produced by dissolving the PVA powder in the degassed water at least once.

One side of the semi-solid hydrated gel is inserted into the ultrasonic transducer so as to be free from the ultrasonic transducer and corresponds to the outer shape of the ultrasonic transducer, and the inner circumferential surface of the one side includes a helical groove corresponding to the helical protrusion located on the outer surface of the applicator .

Further, the other surface of the semi-solid hydrated gel may be formed in a conical shape in which the cross-sectional area is narrowed toward the biotissue so as to correspond to the ultrasonic wave in which the focus is placed in the biotissue.

The ultrasonic wave generator includes an electric signal generator for generating an electric signal having a continuous RF frequency, a waveform modulator located at one side of the electric signal generator, for modulating the electric signal into a spherical waveform or a sinusoidal waveform, And a linear amplifier provided at one side of the waveform modulator and amplifying the modulated waveform.

Further, the ultrasonic transducer may be in the form of a removable lens whose focal point is located at a depth of 1 mm to 20 cm inside the living tissue.

The plurality of ultrasound transducers may be provided in different focuses, and the semi-solid hydrated gel may be provided in plurality corresponding to each of the plurality of ultrasound transducers having different focal points.

A method for manufacturing a semi-solid hydrated gel according to another embodiment of the present invention for realizing the above-mentioned problems includes a first step of removing gas from water, a second step of dissolving PVA powder in the degassed water, ; And a third step in which the solution produced in the second step is frozen and thawed at least once.

In the second step, the temperature of the water is 70 to 90 degrees Celsius, the concentration of the powder in the solution is 5 to 7 percent by mass with respect to the solution, the freezing temperature in the third step is minus 20 to 30 degrees Celsius, The thawing temperature may be room temperature.

The present invention relates to a concentrated ultrasound generator capable of freely moving up and down, left and right, and at an angle, using a conventional bag filled with air removed water, a solid receiver for enclosing a hydrated gel, and a semi-solid hydrated gel replacing a solid hydrated gel To the user.

Specifically, the ultrasonic generator can be directly attached to the ultrasonic generator without any support or cage, can be stored for a long time in sterilized water in which air is removed, molded or molded into various shapes, and manufactured in a disposable manner, It is possible to provide a user with an intensive ultrasonic generator that is made of a material and uses a semi-solid hydration gel without skin irritation.

It should be understood, however, that the effects obtained by the present invention are not limited to the above-mentioned effects, and other effects not mentioned may be clearly understood by those skilled in the art to which the present invention belongs It will be possible.

BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate preferred embodiments of the invention and, together with the description, serve to further the understanding of the technical idea of the invention, It should not be construed as limited.
1 is a cross-sectional view of an intensive ultrasound generator using an air-depleted water-filled bag according to the prior art.
2 is a cross-sectional view of a concentrated ultrasound generator using a semi-solid hydrated gel according to the present invention.
3 is an exploded cross-sectional view of a concentrated ultrasound generator using a semi-solid hydrated gel according to the present invention.
4 is an explanatory diagram of the state of use of an ultrasound transducer having a different focal length and an ultrasound generator using a corresponding semi-solid hydrated gel according to the present invention, respectively.
5 is a cross-sectional view illustrating an embodiment of an applicator for securing a detachable ultrasonic transducer related to the present invention.
FIG. 6 and FIG. 7 are views showing the state of use of the concentrated ultrasound generator according to the compression of a living tissue of a semi-solid hydrated gel according to the present invention.
8 is a flow chart for explaining a method of manufacturing a semi-solid hydrated gel according to the present invention.

Intensive ultrasound refers to the ultrasound energy used to concentrate on the focus to be delivered. In the past, intensive ultrasound was medically used as a non-invasive method of controlling the function of nerve tissue. At this time, a device for generating intensive ultrasonic waves was developed by scientists in the 1950s and 1960s. When electric current is applied to various piezoelectric materials, electric waves can be converted into mechanical waves, and piezoelectric materials can be converted into gas- When activated, it converts to an ultrasonic pressure shock waveform of 20KHz or more. This shock wave is generated in the piezoelectric material arranged in a hemispherical shape, and is concentrated in a position corresponding to the radius of the circumference.

However, when the intensive ultrasonic wave is transmitted to the living tissue, when the space between the intensive ultrasonic generator and the living tissue is generated, the ultrasonic wave is not properly transmitted to the body due to the cause of the attenuation due to the air.

In other words, almost 100% reflection of ultrasonic waves occurs at the interface between air and living tissue, and even if minute bubbles are present, the propagation of ultrasonic waves is remarkably reduced and the transmission is not performed.

To prevent this, a space filled with water or a hydrogel similar to a human body or water was filled in a retainer made of air-removed water-filled pouch or solid.

1 is a cross-sectional view of an ultrasonic generator using a pouch filled with water according to the prior art.

1, an intensive ultrasound generator 10 includes an applicator 100, an ultrasound transducer 200, and an ultrasound generator 600. Ultrasonic waves generated in the ultrasound transducer 200 are transmitted to a living body tissue 300 At the time of delivery, a water-soluble gel 510 was applied to a bag 500 filled with air-free water.

However, there is a problem in that when the pouch is used, water leaks, or the liquid concentrator 10 tilts depending on the position, there is a problem that the intensive ultrasonic generator 10 can not move freely up and down and left and right. There was a difficult problem to adjust.

Therefore, the invention proposed in the present application is to provide an ultrasound transducer capable of moving vertically and horizontally and freely, which is composed of a semi-solid body, and is capable of filling the space between the ultrasound transducer 200 and the living tissue 300, And to provide the user with a hydrating gel for delivery to the inside.

Before describing the specific operation of the present invention, the components of the concentrated ultrasonic generator 10 applied to the present invention will be described in detail. However, the embodiment described below does not unduly limit the contents of the present invention described in the claims, and the entire configuration described in this embodiment is not necessarily essential as the solution means of the present invention.

FIG. 2 is a cross-sectional view of a concentrated ultrasound generator 10 using a semi-solid hydrated gel 400 in accordance with the present invention, and FIG. 3 is an exploded cross-sectional view of an intensive ultrasound generator 10 using a semi-solid hydrated gel 400 related to the present invention .

2 and 3, the concentrated ultrasound generator 10 according to the present invention includes an ultrasound generator 600, an applicator 100, an ultrasound transducer 200, and a semi-solid hydrating gel 400.

The ultrasonic generator 600 according to the present invention generates an ultrasonic wave to form a low-intensity ultrasonic wave. The ultrasonic generator 600 includes an electric signal generator 610, a waveform modulator 620, and a linear amplifier 630. At this time, the waveform modulator 620 is provided at one side of the electric signal generator 610, and the linear amplifier 630 is provided at one side of the waveform modulator 620.

The applicator 100 according to the present invention is a device for fixing the position to which the focused ultrasound is transmitted and connecting the ultrasound transducer 200 and the ultrasound generator 600. The applicator 100 is generally cylindrical in shape and has an opening so that the ultrasonic transducer 200 can be seated in the other side opposite to the side where the ultrasonic generator 600 is provided, .

In addition, the outer surface of the applicator 100 may be provided with a helical protrusion 110 for helical coupling.

The ultrasonic transducer 200 according to the present invention is positioned at the opening of the applicator 100 and is formed into a concave lens shape in which the direction of the living tissue 300 is concave so that ultrasonic waves are concentrated at the focal point and focused ultrasonic waves are generated.

At this time, the ultrasonic transducer 200 is manufactured so that the focal point is located within 1 mm to 20 cm of the inside of the living tissue 300, is composed of a piezoelectric material, and is in the form of a removable lens.

The plurality of ultrasound transducers 200 may include a plurality of ultrasound transducers 200 having different types of removable lenses, and the plurality of ultrasound transducers 200 may have different focuses. The ultrasound transducers 200 may be formed as detachable lenses, .

The semi-solid hydration gel 400 is positioned in the space between the ultrasonic transducer 200 and the living tissue 300 and transmits the ultrasonic waves passing through the ultrasonic transducer 200 to the inside of the living tissue 300.

At this time, the semi-solid hydrated gel 400 is characterized in that its shape is deformed according to the external shape of the living tissue 300 due to flexibility, stretchability, and compressibility.

The semi-solid hydrated gel 400 may be inserted into the interior of the ultrasonic transducer 200 so that one side thereof is free from the ultrasonic transducer 200 and may be formed in a shape corresponding to the contour of the ultrasonic transducer 200.

In addition, the inner circumferential surface of the one side may include a helical groove 410 corresponding to the helical protrusion 110 located on the outer surface of the applicator 100.

The applicator 100 and the semi-solid hydration gel 400 to which the ultrasonic transducer 200 is coupled can be spirally coupled and can be easily combined and separated and the space between the ultrasonic transducer 200 and the applicator 100 Can be combined.

The other surface of the semi-solid hydrated gel 400 may be formed in a conical shape in which the cross-sectional area is narrowed toward the biotissue so as to correspond to the ultrasonic waves generated in the biotissue.

The ultrasonic wave transmitted through the ultrasonic transducer 200 is gradually collected toward the living tissue 300. When the semi-solid hydrated gel 400 is configured in a conical shape, the ultrasonic wave transmitted from the ultrasonic transducer 200 to the living tissue 300 Space is not generated. In addition, the thickness of the semi-solid hydrated gel 400 is adjusted according to the focal distance of the ultrasonic wave and the ultrasonic focal distance in the living tissue.

The semi-solid hydrated gel 400 may be configured to correspond to each of the ultrasound transducers 200 configured as a plurality of removable lens shapes configured to have a curvature according to a necessary focal length.

The semi-solid hydration gel 400 may be composed of a material having a minimum sound attenuation and acoustic impedance, and preferably includes water as a main component, and a ratio of 0.8 to 1.5, which is similar to the scattering system constituting the gel, Respectively.

In addition, the semi-solid hydrated gel 400 is preferably composed of a substance free from irritation to the human body. For this purpose, the hydrogel using the biocompatible polymer is a soft elastomer, which can contain a large amount of water, is hydrophilic and has excellent biocompatibility It is more preferable that it is made of a material.

Examples of the biocompatible polymer include polyethyleneglycol (PEG), neophenylglycol diacrylate (NPGDA), polyethylene oxide (PEO), polyacrylamide (PAAm), polyhydroxyethyl methacrylate (PHEMA) (PVA), polyvinyl pyrrolidone (PVP), polylactic acid (PLA), polyglycolic acid (PGA), and polycaprolactone Polyvinyl pyrrolidone, polyvinyl pyrrolidone, polyvinyl pyrrolidone (PCL), gelatin, alginate, carrageenan, chitosan, hydroxyalkylcellulose, alkylcellulose, silicone, rubber, agar, carboxyvinyl copolymer, polydioxolane, polyacrylate, polyvinyl chloride and maleic anhydride / One or more polymers selected from the group consisting of the foregoing, copolymers thereof, or a mixture thereof may be used. More specifically, polyvinyl alcohol may be used.

In the present invention, examples of the compound having an acrylate or methacrylate functional group include 2-hydroxyethyl methacrylate (HEMA), acrylic acid, methacrylic acid, adipic acid hydrazide diamide Acrylate, acrylamide, methacrylamide, and alkyl- (meth) acrylamide. N-mono (meth) acrylamide, N, N-di-C 1 -C 4 alkyl- (meth) acrylamide (meth) acrylamide, N-butyl (meth) acrylate, methyl (meth) acrylate, ethyl (meth) acrylate, , Isobornyl (meth) acrylate, cyclohexyl (meth) acrylate, hydroxyethyl acrylate, hydroxyethyl (meth) acrylate, methacrylate, hydroxypropyl acrylate, hydroxypropylmethacrylate, hydroxybutyl acrylate, N- (2-hydroxyethyl) acrylamide [N- (2- hydroxyethyl acrylamide, N-methyl acrylamide, N-butoxymethylacrylamide, N-methoxymethyl acrylamide, N-methoxymethyl methacrylamide, 2-acrylamidoglycolic acid or 2-carboxyethyl acrylate (for example, 2-carboxyethyl acrylate, 2-hydroxy-5-methoxyacetophenone, 2-hydroxyethyl cellulose and 2-hydroxyethyl disulfide 2-hydroxyethyl disulfide), and more specifically, 2-hydroxyethyl methacrylate (HEMA) may be used.

On the other hand, the polyvinyl alcohol (PVA) related to the present invention is a kind of synthetic polymer, but it has a property of dissolving in water and not dissolving in an organic solvent, and after drying it does not dry well and has a property of absorbing water.

At this time, the hydrogel made using polyvinyl alcohol (PVA) according to the present invention is hydrophilic and biocompatible.

The hydrated gel is prepared by dissolving PVA powder in water at a temperature of 70 to 90 degrees centigrade in which air is removed at a mass percentage of 5 to 7% to prepare a PVA solution, freezing the PVA solution at a temperature of minus 20 to 30 degrees Celsius The defrosting can be repeated at room temperature, and the defrosting and thawing can be performed once to three times.

In this case, even if the water gel is made by removing water from the air, the air is not present in the inside of the gel to prevent the ultrasonic waves from being scattered. When the water temperature is less than 70 degrees, the PVA powder can be prevented from being dissolved in the water. If it exceeds 90 degrees, it is preferable that the temperature of the water is 70 to 90 degrees Celsius to prevent the PVA powder from becoming clumped and hardened before it is dissolved in water.

And PVA powder is preferably used in an amount of 5 to 7% by mass of the total weight of the PVA solution in order to maintain the shape and handling of the aqueous solution.

That is, when the PVA powder exceeds 7% of the weight of the entire aqueous solution, the viscosity becomes high and it is difficult to melt. When the PVA powder is less than 5%, the gel strength suitable for use can not be obtained.

In order to solidify the PVA solution, it is preferable to freeze at a temperature of minus 20 to 30 ° C. To dissolve the PVA solution, the frozen PVA solution is preferably thawed at room temperature, and frozen and thawed are repeated 1 to 3 times And it is possible to produce a semi-solid hydrated gel having elasticity, flexibility and compressibility through adjustment of the number of repetition of freezing / thawing and the time of the freezing period.

4 is a use state diagram of the concentrated ultrasound generator 10 using the ultrasound transducers 200 and 200 'having different focal lengths and the corresponding semi-solid hydrated gel 400 corresponding to the present invention.

4, the ultrasound transducers 200 and 200 'according to the present invention are concave in the body direction 300 to have various focal lengths of ultrasonic waves, and may have various curvatures.

The ultrasonic waves passing through the ultrasonic transducer 200 can be refracted by the curvature of the incident ultrasonic transducer 200, and the degree of refraction varies depending on the magnitude of the curvature. The focal distance of the ultrasonic transducer 200 is changed.

4 (a), the ultrasonic transducer 200 has a focal length of d1 and the ultrasonic transducer 200 'having a different curvature according to FIG. 4 (b) d1 ', and have different focal lengths depending on the application. At this time, the ultrasonic transducers 200 and 200 'are detachably attached to the applicator 100 and can be easily exchanged. The semi-solid hydrated gels 400 and 400 'may be formed to correspond to the ultrasonic transducers 200 and 200' having different curvatures without space.

Next, the concrete action of the concentrated ultrasonic generator 10 applied to the present invention will be described in detail. However, the embodiment described below does not unduly limit the contents of the present invention described in the claims.

The ultrasonic generator 600 converts an electric signal to generate ultrasonic waves. Specifically, the electrical signal generator 610 generates an electrical signal having a continuous RF frequency. The electric signal used here uses a square wave or a sine wave depending on the characteristics of the piezoelectric material. The waveform modulator 620 modulates the waveform of the electric signal having the continuous RF frequency output from the electric signal generator 610 into a spherical waveform or a sine waveform using an envelope. This is to pulse the above-mentioned RF frequency through waveform modulation. The linear amplifier 630 amplifies the modulated spherical or sinusoidal pulse waveform to generate ultrasonic waves.

When the ultrasonic transducer 200 is convex in the direction opposite to the living tissue and the direction of the living tissue is concave so that the direction of the ultrasonic wave is changed by the convex surface of the ultrasonic transducer 200 . This is the same principle as transmitting light to a common lens.

5 is a cross-sectional view showing an embodiment of an applicator 100 for fixing a detachable ultrasonic transducer 200 according to the present invention.

5, an ultrasonic transducer 200 according to an embodiment of the present invention includes an ultrasonic transducer 200 and an ultrasonic transducer 200. The ultrasonic transducer 200 is attached to an outer circumferential surface of the applicator 100, The ultrasonic transducer 200 can be easily worn or dropped off by using the ring-shaped cover 120. [

FIG. 6 and FIG. 7 are views showing the state of use of the concentrated ultrasound generator 10 according to the present invention when the biological tissue 300 of the semi-solid hydrated gel 400 is compressed.

6 and 7, the semi-solid hydrated gel 400 applied to the present invention is flexible, stretchable, and compressible so that its shape can be changed according to the external shape of the living tissue 300, and the ultrasound transducer 200, The space between the living tissues 300 can be filled up and the compact depth of the space between the living tissues 300 can be adjusted, so that the depth of focus of the ultrasonic waves in the living tissue 300 can be controlled.

More specifically, the ultrasonic transducer 200 has a focal length d1 of the ultrasonic wave according to the curvature, and even when the ultrasonic wave is transmitted from the ultrasonic transducer 200 to the inside of the living tissue 300 through the semi-solid hydrated gel 400, The distance d1 is kept constant.

However, the focal distance at which the ultrasonic waves are gathered in the living tissue 300 is d2 before the semi-solid hydrated gel 400 is compressed, but becomes d3 after the semi-solid hydrated gel 400 is compressed, The focal distance of the ultrasonic wave can be adjusted inside the living tissue 300.

The semi-solid hydrated gel 400 has flexibility, stretchability, and compressibility and is deformed according to the external shape of the living tissue 300, so that the ultrasonic wave generated in the ultrasonic wave transducer 200 is dispersed into the living tissue 300 So that the concentrated ultrasound generator 10 can be moved vertically and horizontally and freely without any deviations in a specific direction due to the semi-solid body, which is an intermediate form of liquid and solid.

The intensive ultrasound generator 10 can transmit ultrasonic waves to a desired position in the living tissue 300.

Next, a method of manufacturing the semi-solid hydrated gel 400 applied to the present invention will be described in detail.

8 is a flowchart for explaining a method of manufacturing a semi-solid hydrated gel 400 related to the present invention. Referring to FIG. 8, a first step (S10) of removing air from general water may proceed. In connection with step S10, it is possible to remove water from the water through the method of boiling the water in the container with the cap being opened gradually, closing the cap to prevent contact with the air outside the container and lowering the temperature, After the water is filled, the container can be evacuated to remove air from the water.

After the air is removed from the water, step S20 may be followed in which the air is removed from the mixing vessel. Regarding step S20, the temperature of the air-free water is preferably 70-90 degrees Celsius.

After the water is mixed with the mixing vessel, a second step (S30) in which the PVA powder is dissolved in water to produce a PVA solution may be performed. At this time, the concentration is preferably 5 to 7% by mass with respect to the PVA solution.

After the PVA solution is produced, the step (S40) of filling the formed mold with the PVA solution may proceed. At this time, the container for the mold is formed so that the shape of the semi-solid hydrated gel 400 can correspond to the shape of the ultrasonic transducer 200.

After the PVA solution is filled in the casting mold, a third step (S50) of repeating freezing and thawing of the casting mold can be performed. At this time, the freezing temperature is preferably in the range of minus 20 to 30 degrees Celsius, and the thawing temperature is preferably room temperature. It is preferable that the freezing and thawing are repeated one to three times, and thus a semi-solid hydrated gel having elasticity, flexibility and compressibility can be manufactured.

When the configuration of the present invention described above is applied, when ultrasonic waves are transmitted to the living body tissue 300 through the ultrasonic transducer 200 using the ultrasonic wave generator 10, the ultrasonic wave is not scattered by the air, It is possible to provide a user with an intensive ultrasonic generator 10 that does not use a bag made of air filled with water or a solid water-containing gel or a solid body that surrounds the water-based gel but uses a hydrogel having the same effect . A semi-solid hydration gel having a semi-solid and spiral groove and attached directly to the concentrated ultrasound generator 10, molded or molded in various forms, made of disposable, hygienic, colorless, odorless and non- It is possible to provide the user with an intensive ultrasonic generator 10 using the ultrasonic generator 400.

It is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, is intended to cover various modifications and alternative arrangements included within the spirit and scope of the appended claims. .

10: Intensive ultrasonic generator,
100: Applicator,
110: spiral protrusion fire,
120: a ring-shaped cover with a center open,
200: a first embodiment of an ultrasonic transducer,
200`: a second embodiment of an ultrasonic transducer,
300: biotissue,
400: a first embodiment of a semi-solid hydrated gel,
400 ': a second embodiment of a semi-solid hydrated gel,
410: spiral groove,
500: Pockets filled with air-depleted water,
510: Water-soluble gel,
600: ultrasonic wave generator,
610: electric signal generator,
620: waveform modulator,
630: linear amplifier,
d1: the focal distance according to the first embodiment of the ultrasonic transducer
d1 ': the focal distance according to the second embodiment of the ultrasonic transducer
d2 is the focal length in the biotissue of the ultrasound transducer according to the semi-solid hydrogel before compression,
d3: Focal distance of the ultrasound transducer in the biotissue according to the semi-solid hydrogel after compression.

Claims (10)

An ultrasound generating unit for generating ultrasound transmitted to a living tissue;
An applicator connected at one side to the ultrasonic wave generator and having an opening at the other side for fixing the position where the ultrasonic wave is transmitted to the living tissue;
An ultrasonic transducer positioned at an opening of the applicator and recessed in a direction toward the living tissue, the ultrasonic transducer transmitting ultrasound transmitted through the applicator to the living tissue using the concave lens shape; And
And a semi-solid hydrated gel positioned between the ultrasound transducer and the biotissue to support the delivery of the ultrasound to the biotissue,
Wherein the ultrasonic wave transmitted to the living tissue is concentrated ultrasonic wave focused on a focus by a concave lens shape of the ultrasonic wave transducer,
The semi-solid hydrated gel,
Wherein the PVA powder is dissolved in water without gas being stimulated to the human body and the resulting solution is composed of a hydrophilic PVA which is produced by repeating at least one cycle of freezing and thawing,
And is deformed according to the external shape of the living tissue with flexibility. delete delete The method according to claim 1,
One side of the semi-solid hydration gel is drawn into the interior of the ultrasonic transducer so as to be free from the ultrasonic transducer and corresponds to the contour of the ultrasonic transducer,
Wherein the inner circumferential surface of the one surface includes a helical groove corresponding to a helical protrusion positioned on the outer surface of the applicator. 5. The method of claim 4,
Wherein the other surface of the semi-solid hydrated gel is formed in a conical shape such that a cross-sectional area thereof becomes narrower toward the biotissue so as to correspond to the ultrasonic wave in which the focus is located. The method according to claim 1,
Wherein the ultrasonic generator comprises:
An electrical signal generator for generating an electrical signal having a continuous RF frequency;
A waveform modulator located at one side of the electrical signal generator and modulating the electrical signal into a rectangular waveform or a sinusoidal waveform; And
And a linear amplifier provided at one side of the waveform modulator for amplifying the modulated waveform. The method of claim 1, wherein
Wherein the ultrasonic transducer is in the form of a removable lens whose focal point is located at a depth of 1 mm to 20 cm inside the living tissue. 8. The method of claim 7,
The ultrasonic transducer includes a plurality of ultrasonic transducers,
Wherein the plurality of semi-solid hydrated gels are provided corresponding to each of the plurality of ultrasonic transducers having different foci. delete delete

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