KR101510004B1 - A human body model device for analyzing of contrast media characteristic - Google Patents

Abstract

The present invention provides a human body model apparatus for analyzing characteristics of a contrast medium. The apparatus includes: a pulse pump which pumps injected fluid; a damper which reduces high pressure when the damper receives the pumped fluid and the fluid flows; a tachometer which measures a flow rate after receiving the fluid of which high pressure has been reduced; a lung module which receives the fluid of which the flow rate is measured, generates resistance pressure to reduce pressure of a rear end portion by a predetermined level to be lower than pressure of a front end portion, and then discharges the fluid; and a control unit which adjusts pressure of the front end portion and the rear end portion by using an input variable and an output variable. The contrast medium is injected in a front end portion of the lung module. According to the present invention, a standardized injection amount of the contrast medium, injected in the front end portion of the lung module, can be set; the best video image can be obtained with the minimized injection amount of the contrast medium; and vortex or turbulence of waves, generated by high pressure of the fluid coming out of the pulse pump, can be prevented.

Description

[0001] The present invention relates to a human body model device for analyzing contrast agent characteristics,

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a human body model apparatus, and more particularly to a human body model apparatus that controls each component of pulsatility using a precise control means in a pulsatile flow system, artificially reproduces a change in blood flow in the human body, And to a human body model apparatus for analyzing contrast agent characteristics capable of analyzing contrast enhancement characteristics.

In general, contrast media is a medicine that increases the degree of contrast of images by artificially increasing the X-ray absorption difference of each tissue so that the tissue or blood vessels can be seen well in the case of computer tomography (CT) imaging.

In the field of tomography, especially in the field of computed tomography or nuclear magnetic resonance (NMR) tomography, contrast is low because of the low display contrast for the display of a specific part of a living body, contrast enhanced image is preferably obtained.

However, since the contrast agent usually imposes a burden on the living body, it is necessary to reduce the dose as much as possible. In order to determine how the contrast concentration of the contrast medium administered for the biological variability of the subject develops temporally in the observed position in the living body Sufficiently accurate information is not obtained.

Recently, the introduction of high-contrast contrast agent has been performed in a medical field where magnetic resonance imaging or computed tomography is performed, in which a small amount of high-contrast agent is injected slowly and a large amount of low-contrast agent is injected without any definite criterion.

Therefore, it is necessary to observe a time lapse of the concentration value at the position of interest in the subject after injection based on the test infusion administration of the contrast agent in each test subject.

For this purpose, a human body model device capable of automatically performing blood circulation is required. Conventional automatic heart massage devices and the like can automatically inject a contrast agent into a fluid. However, CT imaging is performed in the gantry of a CT as the device is mounted. There is a problem that artifacts derived from materials constituting the apparatus are observed.

Although there have been many techniques for obtaining a fluid image by providing a pulsation pump for forcibly circulating a liquid in a fluid and a contrast agent applying means for injecting a contrast agent into a circulating liquid in the past, There is a problem in that a vortex or a turbulence phenomenon of a wave occurs.

The object of the present invention is to implement a pulsatile system and a closed circuit similar to the human body, to arbitrarily adjust various parameters for a region of interest of a living body model, and to use the resistance pressure of the lung module to pre- And to provide a human body model device for analyzing contrast agent characteristics that can be simulated.

In order to accomplish the above object, the present invention provides a human body model apparatus for analyzing contrast agent characteristics, comprising: a pulsation pump for pumping an inflow fluid; A damper for relieving a high pressure when a fluid flows into the pumped fluid; A flow meter for measuring the flow velocity of the fluid having the high pressure-relieved flow; A waste module that receives the measured flow rate of the fluid and generates a resistance pressure to reduce the pressure of the rear end by a predetermined pressure than the front end and discharge the pressure; And a control unit for adjusting pressures at the front and rear ends of the closed module using an input variable and an output variable, wherein the contrast agent is injected into the front end of the closed module.

In order to achieve the above object, the present invention provides a human body model device for analyzing contrast agent characteristics, comprising: a rotating cam driven by an external motor; A crankshaft eccentrically connected to the cam to transmit rotational motion of the cam; A piston reciprocatingly receiving the rotational motion of the cam; A cylinder having the piston therein, a cylinder for introducing the fluid from the water tank into a reciprocating motion of the piston and discharging the fluid to the outside; And first and second check valves provided on both sides of the pulsation pump to prevent the fluid flowing into and out of the cylinder from flowing backward.

In order to accomplish the above object, the damper of the human body model apparatus for analyzing the contrast agent characteristic of the present invention has a concave-convex connection pipe for introducing the fluid to be pumped into one side and discharging the fluid with high pressure relief to the other side; A corrugated hose having a length controlled by expansion and contraction of a fluid received through a central channel of the connection pipe and containing a fluid; A length adjuster coupled to an upper portion of the pleated hose; A cylindrical case surrounding the corrugated hose and the length adjuster; And a cap mounted on an upper opening of the case and adapted to expand and contract the pleated hose through an upward and downward movement.

In order to achieve the above object, the pleated hose of the human body model apparatus for analyzing the contrast agent characteristic of the present invention has a female screw shape inside, and the length adjusting unit has a male screw shape on the outside.

In order to accomplish the above object, the present invention provides a human body model apparatus for analyzing contrast agent characteristics, comprising a saline container and a contrast agent container, wherein the amount of the saline solution and the contrast agent filled in the saline container and the contrast agent container are adjusted, And a contrast agent injection unit injecting the contrast agent into the front end of the closed module at a predetermined speed.

In order to accomplish the above object, a human body model apparatus for analyzing the contrast agent characteristic of the present invention comprises a first pressure gauge for measuring a pressure of fluid in the aorta portion through a hose connected through an opening formed in aorta portion; A second pressure gauge for measuring a pressure of the fluid in the pulmonary artery through a hose connected through an opening formed in the pulmonary artery; And a third pressure gauge for measuring a pressure of the fluid in the pulmonary vein part through a hose connected through an opening formed in the pulmonary vein part.

In order to achieve the above object, the controller of the human body model apparatus for analyzing the contrast agent of the present invention receives the fluid velocity measured by the anemometer and the fluid pressure measured by the first to third pressure gauges, And a control unit.

In order to accomplish the above object, the present invention provides a human body model apparatus for analyzing contrast agent characteristics, further comprising a water tank having a partition wall for separating the outflow portion and the inflow portion from each other, .

In order to achieve the above object, the closed module of the human body model apparatus for analyzing the contrast agent characteristic of the present invention comprises: a housing; A partition wall dividing the internal space of the housing into a predetermined volume ratio; And a filter filled in the divided inner space to generate the resistance pressure.

In order to achieve the above object, the input parameters of the human body model apparatus for analyzing the contrast agent of the present invention include heart rate, diastolic and systolic ratio of heart, tube voltage, dose of contrast agent, osmolality, viscosity and volume the concentration of the iodine, the delivery rate and the volume of the iodine, the injection rate and the injection duration of the iodine, and the saline volume.

In order to achieve the above object, the output variable of the human body model apparatus for analyzing the contrast agent characteristic of the present invention includes a histogram distribution and an average value curve according to time, a house field unit according to time, a maximum house field unit, Time and an expansion rate of the contrast agent.

According to the present invention, the pressure applied to the front end of the closed module can be reduced to set the standardized dose of the contrast agent injected at the front end of the closed module.

In addition, it is possible to acquire the best medical image image with the minimum amount of contrast agent and to prevent vortex or turbulence of the wave caused by the high water pressure of the fluid coming from the pulsation pump.

1 is a block diagram of a human body model apparatus for analyzing contrast agent characteristics according to the present invention.
Fig. 2 is a schematic configuration diagram of the pulsation pump 200 shown in Fig.
3 is a schematic diagram of the damper 300 shown in FIG.
4 is a schematic configuration diagram of the waste module 700 shown in FIG.

Hereinafter, preferred embodiments of a human body model apparatus for analyzing contrast agent characteristics according to the present invention will be described with reference to the accompanying drawings.

FIG. 1 is a block diagram of a human body model apparatus for analyzing contrast agent characteristics according to the present invention. The human body model apparatus includes a water tank 100, a pulsation pump 200, a damper 300, an anemometer 400, aorta 500, A pulmonary module 700, a pulmonary vein section 800, first to third pressure gauges 550, 650 and 850, a control section 900 and a contrast injection section 1000.

2 is a schematic configuration diagram of the pulsation pump 200 shown in Fig. 1, and includes a cam 220, a crankshaft 240, a piston 260, and a cylinder 280. [

FIG. 3 is a schematic view of the damper 300 shown in FIG. 1, and includes a connecting pipe 320, a pleated hose 340, and a length adjusting portion 360.

4 is a schematic configuration diagram of the waste module 700 shown in FIG. 1 and includes an inlet 720, an outlet 740, a partition 750, a filter 760, and a housing 780.

The function of each component of the human body model apparatus for analyzing the contrast agent characteristic according to the present invention will be described with reference to FIGS. 1 to 4. FIG.

The water tank 100 includes an inlet 120 and an outlet 140. A partition wall (not shown) is provided at an intermediate portion of the water tank 100 to receive the fluid through the inlet 120, As shown in FIG. Here, the fluid is a component having viscosity similar to that of the human body. In order to adjust the viscosity value close to 1.35 cP, which is the viscosity of human plasma at body temperature, a solution in which glycerin is added to a buffer solution containing an electrolyte is used.

The pulsation pump 200 includes a cam 220, a crankshaft 240, a piston 260, a cylinder 280, first and second check valves 290 and 295, one side of which is connected to the hose The fluid discharged from the water tub 100 flows into the cylinder 280 due to the rotational movement of the cam 220 and the reciprocating motion of the piston 260 and is discharged to the outside through the hose on the other side.

The damper 300 includes a connection pipe 320, a corrugated hose 340, a length adjuster 360, a case 380, and a stopper 390. The damper 300 includes a hose connected to one side, Thereby relieving a large pressure when the fluid passes through the hose.

The flow meter 400 measures a flow rate and a flow rate of fluid delivered from the damper 300 through a hose connected to one side. Here, the flow meter 400 uses an electromagnetic induction flow meter.

The aortic part 500 receives the fluid from the anemometer 400 at one side and transfers it to the hose at the other side.

The first pressure gauge 550 measures the pressure of fluid in the aorta portion 500 through a hose connected through an opening formed in the middle of the aorta portion 500.

The pulmonary artery portion 600 receives the fluid delivered from the aorta portion 500 through a hose connected to the aorta portion 500 on one side and transmits the fluid to the hose connected to the other side.

The second pressure gauge 650 measures the pressure of the fluid in the pulmonary artery portion 600 through the hose connected through the opening formed in the middle of the pulmonary artery portion 600.

The pulmonary module 700 receives the fluid delivered from the hose connected to the other side of the pulmonary artery 600 through the inlet 720, generates a resistance pressure through a filter provided inside, And discharges the decompressed fluid through the outlet 740.

One side of the contrast injection unit 1000 is connected to the pulmonary artery unit 600 and the other side of the contrast injection unit 1000 is connected to the user terminal 2000 and is connected to the saline container 1100 and the contrast agent container 1200 in response to the control of the user terminal 2000 The amount of the saline solution and the contrast agent are adjusted and mixed, and then the mixture is injected into the front end of the waste module 700 at a predetermined speed.

The pulmonary vein part 800 is connected to the inlet port 120 of the water tub 100 through a hose connected to the other end of the pulmonary vein part 800 through a hose connected to the outlet 740 of the waste module 700, ).

The third pressure gauge 850 measures the pressure of the fluid in the pulmonary vein section 800 through a hose connected through an opening formed in the middle of the pulmonary vein section 800.

The control unit 900 receives the fluid flow rate and the flow velocity measured by the flow velocity meter 400 and the fluid pressure measured by the first to third pressure gauges 550, 650, and 850 and uses the resistance pressure of the waste module 700 Thereby regulating the pressure applied to the front end and the rear end of the closing module 700.

The operation of the human body model apparatus for analyzing the contrast agent characteristic according to the present invention will be described with reference to FIGS. 1 and 4. FIG.

First, the human body model of the present invention reproduces the velocity and pressure of the blood flow in the aorta 500, and is a model suitably manufactured to acquire images by CT.

For this, the contrast injection unit 1000 adjusts the amount of the saline solution and the contrast agent in response to the control of the user terminal 2000 connected to the other side, and then injects the mixed solution into the front end of the waste module 700 at a predetermined speed.

The water tank 100 contains the fluid and discharges the fluid through the outlet 140 according to the operation of the pulsation pump 200 and receives the fluid from the waste module 700 through the inlet 120.

At this time, a partition wall separating the outflow portion and the inflow portion is provided in the middle of the inside of the water tank 100 to prevent the air contained in the inflow fluid from being introduced together when the discharged fluid is injected into the apparatus.

In addition, when the discharged fluid is filled in the apparatus, the water tub 100 can be detached and modularization of the closed circulation becomes possible.

When the external DC motor rotates the cam 220, the crankshaft 240 is driven so that the piston 260 in the pulsation pump 200 reciprocates.

Through which the fluid is introduced from the water tub 100 through the hose and sucked into the cylinder 280 to discharge the sucked fluid out of the cylinder 280.

At this time, the cardiac output amount is changed on the principle that the volume of the cylinder 280 varies according to the distance between the cam 220 and the crankshaft 240. [

The amount of cardiac output can be adjusted by adjusting the crankshaft 240 of the pulsation pump 200 so that the volume of the cylinder 280 can be adjusted to 50 to 90 cc and the cycle of the pulsatile flow and the duty ratio Duty ratio can be adjusted to achieve the arrhythmia can be adjusted to adjust the heart rate per minute.

In addition, the first and second check valves 290 and 295 in the pulsation pump 200 prevent the fluid, which is sucked into the cylinder 280, from flowing backward as the valve prevents the blood from flowing backward in the heart of the human body.

2, when the piston 260 in the pulsation pump 200 moves upward, the first check valve 290 is opened and the second check valve 295 is closed so that fluid flows from one side of the pulse pump 200 to the cylinder 280 And when the piston 260 moves downward, the first check valve 290 is closed and the second check valve 295 is opened so that the fluid is discharged only from the cylinder 280 to the other side of the pulse pump 200 .

The damper 300 has a hose connected to a flow path on both sides of the connection pipe 320 and a wrinkle hose 340 connected to a central flow passage. A female screw formed on the inner wall of the wrinkle hose 340 is formed on the outer wall of the length adjusting part 360 The male thread is fastened.

The cylindrical case 380 surrounds the outer periphery of the pleated hose 340 and the length adjuster 360 and the cap 390 is mounted on the upper opening of the case 380 to move the pleated hose 340 upward and downward, And absorbs the impact when a flow of energy of the fluid discharged from the pulsation pump 200 through the hose passes through the blood vessel.

In other words, the blood from the actual heart's ventricle is ejected by the high pressure of the ventricle at a velocity of 100 cm / s to the aorta, where the aorta is subjected to tremendous pressure.

Conventionally, in order to mitigate the impact of such a pressure, a silicon tube is used to obtain a compliance function. However, there is a problem that the silicone tube is collapsed in the diastole and the hose surface abuts to obstruct fluid flow. 300) was formed as a bellows type hose (340) which can be stretched and expanded.

In Fig. 3, the convex coupling pipe 320 is connected to a PVC hose having an inner diameter of 17 to 21 mm on both sides, and a bellows hose 340, which is a rubber material expandable and contractible, is connected to the upper side.

The length of the bellows is limited so as to be increased by the amount of one stroke that occurs when the pulse pump 200 is contracted.

In addition, although the length of the damper 300 is conventionally adjusted by using a weight having a predetermined weight, there is a problem in that the effect of the diastole is large. In the present invention, the bellows is manually inserted through the stopper 390, A cylindrical length adjusting portion 360 for adjusting the extending length is employed.

At this time, the length adjuster 360 has a male thread shape and the bellows has a female thread shape so as to be tightly coupled. The length of the damper 300 is adjusted according to the tucking force of the bellows through the stopper 390.

The flow meter 400 is connected to a hose connected to one side of the damper 300 to measure a flow rate and a flow rate of the fluid transmitted from the damper 300.

The aortic part 500 is a circular tube having one side connected to the flow meter 400 and the other side connected to the hose. The aeration part 500 receives the fluid from the anemometer 400 and transfers the fluid to the hose on the other side. The length of the aorta portion 500 is preferably 45 to 55 cm, and the material is preferably acrylic.

At this time, the pressure of fluid in the aortic part 500 is measured by making a hole in the middle of the tube and connecting a hose having an outer diameter of about 3 mm and connecting the first pressure gauge 550.

The hose connected to the other side of the aortic part 500 extends in the longitudinal direction to be connected to the pulmonary artery part 600 and the pulmonary artery part 600 is connected to the inflow port 720 of the pulmonic module 700 to flow the fluid.

The waste module 700 includes a rectangular parallelepiped housing 780 having partition walls 750 dividing the inner space into asymmetric volume ratios of 55:44 on the right and left sides as in the human body, Is filled with a filter made of a material of the same material.

Accordingly, a fluid is introduced from the pulmonary artery 600 through the inlet 720, and a resistance pressure is generated through the filter through a filter provided on the inner side so that the pressure at the rear end of the pulmonary module 700 is reduced And discharges the decompressed fluid through the outlet 740

At this time, the size of the waste module 700 is determined by calculating the blood volume flowing into the lungs in the actual human body.

The pulmonary vein part 800 is connected to the outlet 740 of the pulmonary module 700 and the hose is connected to the other side of the pulmonary vein part 800 so that the fluid discharged from the pulmonary module 700 flows to the inlet 120 of the water tub 100, The fluid from the waste module 700 is introduced through the fluid line.

The control unit 900 receives the fluid flow rate and the flow velocity measured by the flow velocity meter 400 and the fluid pressure measured by the first to third pressure gauges 550, 650, and 850, And regulates the pressure applied to the front end and the rear end of the closing module 700 using the input variable, the output variable, and the resistance pressure of the closing module 700. [

That is, by controlling the input variable and the output variable and by reducing the pressure applied to the front end of the closed module 700 by the resistance pressure of the closed module 700, the reduced pressure is applied to the rear end of the closed module 700, A standardized dose of the contrast agent injected at the front end of the contrast medium 700 can be set.

In other words, the flow rate of the fluid can be obtained through the flow meter 400 connected to the front end of the aortic part 500 and the pulmonary artery part 600 and the pulmonary module 700, which are the anterior part of the aortic part 500, The pressure of the fluid can be obtained through the first to third pressure gauges 550, 650, and 850 connected to the pulmonary artery portion 600,

For example, in the aortic part 500, the flow rate is 100 cm / s and the fluid pressure is 120/80 mmHg.

However, in the human body model of the pulsatile fluid system, the velocity and pressure of the fluid in the closed module 700 by the pulsation pump 200 are lower than the position of the aorta portion 500 by the flow resistance during the flow of the fluid, But it is a large value when compared with the actual human body.

Accordingly, in the present invention, a pressure such as a nonwoven fabric is used in the inside of the closed module 700 to generate the resistance pressure of the closed module 700 so that the pressure of the downstream end of the closed module 700 is reduced to 3 - 8 mmHg.

Here, the LabView programming language is a programming language for graphically programming and controlling the measuring system and acquiring, processing, and displaying data, and is a well-known technology widely used for analyzing measured data. .

The input variables were heart rate, diastolic and systolic ratio of heart, tube voltage, contrast dose, osmolality, viscosity and volume of fluid, concentration of iodine, delivery rate and volume, Injection rate, injection duration, and saline volume.

In addition, the output parameters include the HU distribution and the average curve over time, the house field unit, the maximum house field unit, the contrast arrival time, and the contrast ratio of the contrast agent over time.

For example, a 5 L volume of glycerin is used to satisfy a viscosity of 1.35 cP corresponding to the viscosity of the fluid, and a constant temperature water bath at 37 캜 is used to keep the viscosity constant.

1, a x b is preferably a bed size of (55 to 65) x (290 to 300) cm, and c is preferably a bore size of CT of 65 to 75 cm.

On the other hand, as an output value of each input parameter of the closed module 700, an optimal contrast image can be obtained by using a contrast agent using a neural network algorithm technique.

For example, a contrast agent use parameter to obtain an optimal image in a person having a heart rate of 70 rpm, a cardiac output, and a stroke volume, .

Here, the neural network algorithm technology is an analytical technique adopted by a computer to solve a problem in a manner similar to a method of handling a problem through a human brain, and is widely used for analyzing data The detailed description thereof is omitted here.

Meanwhile, the multi-channel CT image obtained by the present invention is transferred to a system for analysis, and then the image enhancement characteristics of each pixel are analyzed using self-made curve analysis and commercial software MATLAB.

At this time, as the output variable, a histogram of concentration enhancement (HU) distribution and an average value curve are used.

That is, the CT unit 3000 having the operator computer acquires quantitative information about each point on the curve and obtains a concentration curve with respect to the interpolated time through analysis of the output data by the time phase per pixel.

The control unit 900 receives data on the flow rate and flow rate of the fluid measured by the flow velocity meter 400 and the fluid pressure measured by the first to third pressure gauges 550, 650, and 850, Language, transmits the processed data to the user terminal 2000, and controls the pulsation pump 200.

Then, the simulation is programmed through a variable adjustment technique that selects the ideal time versus concentration curve and approximates the ideal curve by comparing it to the actual acquired data.

As described above, the human body model apparatus for analyzing the contrast agent characteristic according to the present invention implements a pulsating system similar to the human body and a closed circuit, arbitrarily adjusts various variables for a region of interest of the living body model, It is possible to simulate various clinical phenomena and results in advance.

In this way, it is possible to set the standardized dose of the contrast agent injected at the front end of the lung module by reducing the pressure applied to the front end of the lung module, obtain the best medical image image with the minimum amount of contrast agent, It is possible to prevent swirling and turbulent phenomena of the waves caused by the high hydraulic pressure of the fluid coming out.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the invention as defined in the appended claims. It will be understood that the present invention can be changed.

100: water tank
200: Pulsation pump
300: damper
400: Flowmeter
500: aorta portion
550: First pressure gauge
600: Pulmonary artery portion
650: Second manometer
700: closed module
800: Pulmonary vein part
850: Third pressure gauge
900:
1000: contrast injection unit

Claims (11)

A pulsation pump for pumping the introduced fluid;
A damper for relieving a high pressure when a fluid flows into the pumped fluid;
A flow meter for measuring the flow velocity of the fluid having the high pressure-relieved flow;
A waste module that receives the measured flow rate of the fluid and generates a resistance pressure to reduce the pressure of the rear end by a predetermined pressure than the front end and discharge the pressure; And
A controller for adjusting pressures at the front and rear ends of the closed module using an input variable and an output variable;
And,
And injecting a contrast agent into a front end of the closed module.
Human body model device for contrast agent characterization.
The method according to claim 1,
The pulsation pump
A cam rotated by driving of an external motor;
A crankshaft eccentrically connected to the cam to transmit rotational motion of the cam;
A piston reciprocatingly receiving the rotational motion of the cam;
A cylinder having the piston therein, a cylinder for introducing the fluid from the water tank into a reciprocating motion of the piston and discharging the fluid to the outside; And
First and second check valves provided on both sides of the pulsation pump to prevent the fluid flowing into and out of the cylinder from flowing backward;
And a control unit
Human body model device for contrast agent characterization.
The method according to claim 1,
The damper
A coupling pipe having a concavo-convex shape for introducing the fluid to be pumped into one side and discharging the fluid having the high pressure relieved to the other side;
A corrugated hose having a length controlled by expansion and contraction of a fluid received through a central channel of the connection pipe and containing a fluid;
A length adjuster coupled to an upper portion of the pleated hose;
A cylindrical case surrounding the corrugated hose and the length adjuster; And
A cap mounted on an upper opening of the case to expand and contract the pleated hose through vertical movement;
And a control unit
Human body model device for contrast agent characterization.
The method of claim 3,
The pleated hose has a female thread shape inside,
Wherein the length adjuster has an external thread shape.
Human body model device for contrast agent characterization.
The method according to claim 1,
The human body model device
And a controller for controlling the amount of the saline solution and the contrast agent filled in the saline solution container and the contrast agent container and injecting the mixed contrast agent into the front end of the waste module at a predetermined speed, ;
Further comprising:
Human body model device for contrast agent characterization.
The method according to claim 1,
The human body model device
A water reservoir for storing the introduced fluid and having an outlet and an inlet;
A first pressure gauge for measuring a pressure of fluid in the aorta through a hose connected through an opening formed in the aorta;
A second pressure gauge for measuring a pressure of the fluid in the pulmonary artery through a hose connected through an opening formed in the pulmonary artery; And
And a third pressure gauge for measuring a pressure of the fluid in the pulmonary vein part through a hose connected through an opening formed in the pulmonary vein part,
Wherein one side of the aorta portion is connected to the anemometer and the other side of the aorta portion is connected to one side of the pulmonary artery portion through a hose,
The other side of the pulmonary artery portion is connected to an inlet of the closed module through a hose,
Wherein one side of the pulmonary vein part is connected to an outlet of the closed module through a hose and the other side of the pulmonary vein part is connected to an inflow part of the water tank through a hose.
Human body model device for contrast agent characterization.
The method according to claim 6,
The control unit
Wherein the controller controls the pulsation pump by receiving a flow velocity of the fluid measured by the flow velocity meter and a pressure of the fluid measured by the first to third pressure gauges.
Human body model device for contrast agent characterization.
The method according to claim 1,
The human body model device
A water tank having a partition wall for separating the outflow portion and the inflow portion from each other, storing the inflowed fluid, and detachable;
Further comprising:
Human body model device for contrast agent characterization.

The method according to claim 1,
The closed module
housing;
A partition wall dividing the internal space of the housing into a predetermined volume ratio; And
A filter filled in the divided inner space to generate the resistance pressure;
And a control unit
Human body model device for contrast agent characterization.

The method according to claim 1,
The input variable
Volume and volume of fluid, concentration of iodine, rate of delivery and volume, rate of injection (rate of injection), volume of fluid, volume of fluid, ), An injection duration and a saline volume.
Human body model device for contrast agent characterization.
The method according to claim 1,
The output variable
Wherein the contrast enhancement concentration (HU) distribution and the average value curve over time, the house field unit over time, the maximum house field unit, the contrast agent arrival time, and the expansion factor of the contrast agent,
Human body model device for contrast agent characterization.

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