KR101494660B1 - Polyurethane Foam Dressing having improved adhesive property - Google Patents

Abstract

The present invention relates to a polyurethane foam for dressing formed from a polyurethane foam, a pressure-sensitive adhesive layer and a release film, wherein the pressure-sensitive adhesive layer comprises a polyurethane pressure-sensitive adhesive which is composed of a polyether polyol and isocyanate, To a polyurethane foam dressing having improved tackiness formed by mixing 1: 9 to 9: 1.

Description

TECHNICAL FIELD [0001] The present invention relates to a polyurethane foam dressing having improved tackiness,

The present invention relates to a polyurethane foam dressing used as a wound dressing, and more particularly, to a polyurethane foam dressing having improved tackiness in which the adhesive does not transfer to the skin.

Skin is a body organ that protects the human body from external stimuli, prevents moisture loss, and controls important body functions such as body temperature control and prevention of bacterial invasion. If skin loses its function due to various traumas, Side effects and bacterial infections from the outside, which makes it difficult to treat the affected part, or causes secondary side effects such as secondary dysfunction. In severe cases, it affects life extension. Therefore, in order to accelerate the treatment of wounds and to minimize secondary side effects, it is essential to treat wounds using appropriate dressings.

The dressing used for the wound of the skin used the bandage using the cotton material having excellent water absorption ability at the beginning, but the dressing of the cotton material did not absorb all of the wound discharge generated from the skin wound, and the wound which was not absorbed dried, So that it is not easy to exchange, and there is a problem that it involves new tissue damage and pain.

Therefore, recently, there are dressings such as film type, hydrocolloid type, hydrogel type, and polyurethane foam type that do not adhere to the wound surface, and polyurethane foam dressing is most widely used because it is easy to apply and absorbs a large amount of wound discharge have.

As a technique related to the above-mentioned polyurethane foam dressing, U.S. Patent Nos. 5,674,917 and 5,744,509 disclose a method of adding a superabsorbent polymer to a polyurethane foam so as to have a high absorption capacity, Korean Patent No. 404140 discloses a polyurethane foam dressing material manufacturing method in which a polyurethane prepolymer having an isocyanate end is mixed with a crosslinking agent, a foaming agent, an additive, and the like, .

The polyurethane foam dressing is a polyurethane foam itself, which has no skin adhesion force and is used by coating a polyurethane foam with a medical pressure-sensitive adhesive. The medical pressure sensitive adhesive is mainly used as a silicone-based pressure sensitive adhesive which does not damage the skin and has excellent adhesion to the skin.

As described above, the polyurethane foam dressing using the medical pressure-sensitive adhesive is adhered to the skin as a silicone-type adhesive when attached to the skin. However, when peeling off for exchange, the adhesive is transferred to the skin or wound, There was a problem that the wound was damaged and another skin contamination occurred.

In order to solve such a problem, Korean Patent No. 1073048 discloses a polyurethane dressing which does not adhere to a skin wound by using a silicone pressure-sensitive adhesive and an acrylic pressure-sensitive adhesive in combination. However, even when a silicon pressure-sensitive adhesive and an acrylic pressure- Has a problem in that the sticking to the wound is somewhat reduced but it can not prevent the adhesive from being transferred to the wound or the skin.

In order to solve the problems of the prior art as described above, the present invention provides a polyurethane foam dressing comprising a polyurethane foam dressing having improved tackiness to prevent the adhesive of the polyurethane foam dressing from being transferred to the skin when the polyurethane foam dressing is attached to and detached from the skin. It is an object of the present invention to provide a urethane foam dressing.

The present invention relates to a polyurethane foam for dressing formed from a polyurethane foam, a pressure-sensitive adhesive layer and a release film, wherein the pressure-sensitive adhesive layer comprises a polyurethane pressure-sensitive adhesive which is composed of a polyether polyol and isocyanate, 1: 9 to 9: 1. The present invention provides polyurethane foam dressings having improved tackiness.

Also, the adhesive layer is formed by mixing a polyurethane adhesive and a silicone adhesive at a weight ratio of 6: 4 to 4: 6. The polyurethane foam dressing has improved adhesion.

The present invention also provides a polyurethane foam dressing having improved tackiness, characterized in that the polyurethane adhesive is of the liquid type.

Further, the polyurethane adhesive is preferably a two-component type curing agent and a curing agent, wherein the curing agent is a prepolymer formed from a polyether polyol and an isocyanate, and the subject is a polyether polyol. A polyurethane foam dressing having adhesiveness is provided.

Further, the polyether polyol has a weight average molecular weight of 500 to 10,000, and provides a polyurethane foam dressing having improved tackiness.

Also, the polyurethane foam dressing having improved tackiness is provided, wherein the silicone pressure sensitive adhesive is a liquid type.

The present invention also provides a polyurethane foam dressing having improved tackiness, wherein the silicone pressure sensitive adhesive is one-pack type.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. First, it should be noted that, in the drawings, the same components or parts are denoted by the same reference numerals whenever possible. In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted so as to avoid obscuring the subject matter of the present invention.

The terms "about "," substantially ", etc. used to the extent that they are used herein are intended to be taken to mean an approximation of, or approximation to, the numerical values of manufacturing and material tolerances inherent in the meanings mentioned, Accurate or absolute numbers are used to help prevent unauthorized exploitation by unauthorized intruders of the referenced disclosure.

FIG. 2 is a cross-sectional view of a polyurethane foam dressing having improved tackiness according to the present invention, and FIG. 3 is a diagram showing that the polyurethane foam dressing having improved tackiness according to the present invention is not transferred to the skin.

The present invention relates to a polyurethane foam for dressing formed from a polyurethane foam 100, an adhesive layer 200 and a release film 300 as shown in Fig.

The polyurethane foam 100 is not particularly limited, and any polyurethane foam that can be used for dressing may be used.

The adhesive layer 200 is formed by mixing a polyurethane pressure-sensitive adhesive synthesized with a polyether polyol and an isocyanate and a silicone pressure-sensitive adhesive.

The polyurethane adhesive of the adhesive layer 200 enhances the adhesive strength with the polyurethane foam 100 so that the high silicone adhesive improves the adhesion to the skin. When the polyurethane adhesive contains less than 10% by weight, the bonding strength between the adhesive layer and the polyurethane foam The adhesive layer may be transferred to the skin. If the silicone adhesive is contained in an amount of less than 10% by weight, the adhesion to the skin may be weakened. Therefore, the polyurethane adhesive and the silicone adhesive are mixed in a weight ratio of 1: 9 to 9: .

The pressure-sensitive adhesive layer is preferably formed by mixing the polyurethane pressure-sensitive adhesive and the silicone pressure-sensitive adhesive in a weight ratio of 7: 3 to 3: 7, and most preferably, the polyurethane pressure-sensitive adhesive is mixed with the silicone pressure-sensitive adhesive at a weight ratio of 6: 4 to 4: .

The polyurethane pressure-sensitive adhesive is prepared by reacting isocyanate with a polyol. The one-pack type polyurethane pressure-sensitive adhesive and the liquid type polyurethane pressure-sensitive adhesive are manufactured and sold. In the present invention, Can be used.

The polyol may be largely divided into a polyester polyol and a polyether polyol and both of the two polyols can be used. Since the polyether polyol is excellent in hydrolysis resistance, low temperature characteristics and softness, It is more preferable to use a polyurethane pressure-sensitive adhesive using a polyol.

The liquid type polyurethane pressure sensitive adhesive is divided into a curing agent and a main component. The curing agent is mainly composed of isocyanate and polyol. The main component is polyol as a main component and is used immediately before use. The polyurethane adhesive of the present invention is used in this liquid type It is preferable that the curing agent is a prepolymer formed from a polyether polyol and an isocyanate and a polyurethane adhesive prepared by using a polyether polyol as a base.

The silicone pressure-sensitive adhesive is an elastic pressure-sensitive adhesive having elasticity under a low surface tension and cured state, and is suitable for the skin. Since the silicone pressure-sensitive adhesive does not generate heat or heat during curing, it can be easily processed as a pressure-sensitive adhesive.

The silicone pressure sensitive adhesive is manufactured and sold as a one-pack type silicone pressure sensitive adhesive and a two-component silicone pressure sensitive adhesive. In the present invention, both of one-component type and two-component type may be used.

In addition, the silicone pressure sensitive adhesive may be any of silicone pressure sensitive adhesives manufactured by silicone manufacturers such as Dow Corning and Blue Star.

The polyurethane pressure sensitive adhesive and the silicone pressure sensitive adhesive may be used in combination, and it may be preferable to control the viscosity of the polyurethane pressure sensitive adhesive and the silicone pressure sensitive adhesive similarly.

The silicone pressure sensitive adhesive preferably has a viscosity of from 2,000 to 60,000 mPa · s (23 ° C.) for convenience in use. To control the viscosity similarly, the polyurethane pressure sensitive adhesive preferably has a weight average molecular weight of 500 to 10,000 It may be preferable to produce it by using an organic solvent.

As the release film 300, any film made of synthetic resin may be used, and a polyester film may be preferably used.

As described above, the polyurethane foam dressing having improved tackiness according to the present invention uses the polyurethane pressure-sensitive adhesive and the silicone pressure-sensitive adhesive so that the pressure-sensitive adhesive layer maintains adhesion with the skin while maintaining a strong adhesive force with the polyurethane foam. When the polyurethane foam dressing is used, the adhesive layer of the polyurethane foam dressing is not transferred to the skin when it is worn on the skin for replacement.

FIG. 1 is a view showing that the conventional polyurethane foam dressing having adhesiveness is transferred to the skin.
2 is a cross-sectional view of a polyurethane foam dressing having improved tackiness according to the present invention.
FIG. 3 is a diagram showing that the polyurethane foam dressing having improved tackiness according to the present invention is not transferred to the skin.

Hereinafter, an embodiment of a method for producing a polyurethane foam dressing having improved tackiness according to the present invention is shown, but the present invention is not limited to the examples.

Example  1 to 10

A polyurethane pressure sensitive adhesive and silicone pressure sensitive adhesive were mixed and coated on a polyurethane foam, and then the release film was covered and cured to prepare a polyurethane foam dressing having improved tackiness according to the present invention.

Wherein the polyurethane pressure-sensitive adhesive is a prepolymer formed of a polyether polyol and isocyanate as a curing agent, and the base is a polyether polyol, the weight average molecular weight of the polyether polyol is 7,000, and the silicone pressure- Medical liquid silicone adhesive was used.

The weight ratios of the polyurethane pressure sensitive adhesive and silicone pressure sensitive adhesive are shown in Table 1.

* Property evaluation experiment

The absorbency, absorbency, peel strength, and probe tack of the polyurethane foam dressing having improved adhesion according to the present invention were measured. The test results are shown in Table 1.

◈ Absorption rate test method

1. Fill the 5 ml disposable syringe with distilled water and measure the time at which the water completely penetrates by dropping at a height of 7 cm

2. Record the average value by dropping 10 times in total

◈ Absorption (Absorption) Test Method

1. Application

This test method is applied to the water absorption test method of the wound dressing.

1) Balance should be able to measure from 100g to 0.0001g unit.

2) This test method requires EN13726-1; Test methods for primary wound dressing-Part 1: Test by Aspects of absorbency test.

2. Devices and furniture

- 500ml PE Bottle

- Petridishes: Width 90 ± 5mm

- Precision electronic scales (METTLER AB204-S)

- pin set

3. Time

- Test solution A

- Composition: NaCl, CaCl ₂ solution (142 mmol Na ion, 2.5 mmol Ca ion)

- Preparation: 8.298 g of NaCl and 0.368 g of CaCl ₂ (H ₂ O) ₂ are dissolved in 1 L of distilled water.

4. Test method

1) Weigh 5cm × 5cm sample and place in 500ml PE bottle.

2) Add test solution A warmed to 37 ± 1 ℃ by the amount corresponding to 40 times the weight of the sample.

At this time, measure to ± 0.5g accurately.

3) Leave the sample in oven at 37 ± 1 ℃ for 24 hours, measure the sample weight after 30 seconds using tweezers.

4) Measure the four specimens in the same way, calculate each of them according to the following formula, and calculate the average.

5. Calculations

- Absorbency per 100 cm 2 of area of the specimen = (Weight after 30 min - Initial weight) / Initial weight x 4

◈ Peel Strength Test Method

1. Application

This test method is applied to the adhesion test of the wound dressing during the characteristic test.

1) Test the adhesion test method of ASTM D 3330 - Method A

2) Standard width is calculated in terms of standard width.

2. Devices and apparatus

- Oven (OF-22)

- 50mm x 125mm trials

- Rubber roller with a weight of 2 kg

- Adhesion tester (AR1000)

3. Test method

[Making and Storing Psalms]

- The specimen shall be cut to a width of 12 mm and a length of 100 to 130 mm.

- In order to minimize the interference of other forces caused by the increase of foam during adhesion test, PET adhesive film is attached to the surface of specimen and stored for one day in a constant temperature and humidity chamber (23 ℃, 50%) for stabilization.

1) Prior to the test, set the grip and the bottom of the tester to 90 ° or 180 ° according to the desired test item and calibrate it.

2) Place the prepared specimen in the longitudinal direction at the center of the test plate which has been left in the oven at 37 ℃ for 10 minutes. At this time, one end should be about 10mm out of the test plate.

3) Pass a rubber roller with a weight of 2,040 g twice at a speed of 10 mm / s on the sample twice, and then tape the length of the specimen to the end of the sample not attached to the test plate.

4) The test plate is fixed to the bottom of the tacking machine, and the tape at the end of the specimen is tilted back to the grip and measured at a speed of 11.8 inch / min.

5) Find the appropriate section in the result graph that appears after the measurement and record the average value.

6) After measuring the remaining 4 specimens in the same way, the average of 5 results is obtained.

◈ Probe Tack Test Method

1. Application

This test method is applied to the probe test method of the wound dressing during the characteristic test.

1) Test conditions

start force: 5 grams / speed: 23.12 in / min

test force: 1000gram / speed: 23.12 in / min

dwell time: 1 second / speed: 23.12 in / min

2) Tested in accordance with ASTM D 2979-01 and Welding Cladding Standards and Test Methods.

2. Devices and apparatus

- Adhesion tester (PMA 1000)

- Probe - Material: STS304 / Diameter: 5mm

- Pressure-Loading weight - the inside diameter is slightly larger than the probe diameter

3. Test method

1) Remove the volatile solvent from the probe and insert the probe.

2) Cut the specimen to the appropriate size and place it on the annular ring weight so that the adhesive side faces upward. The size of the specimen should be sufficient to cover the holes and be free of slip during the test.

3) Press the test button and record the maximum force applied when the probe is removed from the adhesive surface of the specimen at the end of the test.

4) Repeat this 6 times. After each measurement, wipe the probe surface with solvent, dry thoroughly, then start the next measurement.

5) Record the five averages excluding the highest and lowest values.

division Silicone: PU
Weight ratio Hardening
time Absorption degree
(g / g) Absorption rate
(sec) Peel strength
(g / inch) Probe Tack
(g / 25 mm) Example 1 4: 6 25 ° C / 3 min 10.68 45.60 13.54 17.37 Example 2 4: 6 70 ° C / 3min 9.79 50.21 12.60 14.32 Example 3 8: 2 25 ° C / 3 min 10.25 38.97 16.60 19.50 Example 4 8: 2 70 ° C / 3min 10.67 35.15 16.55 18.20 Example 5 7: 3 25 ° C / 3 min 11.00 20.10 17.35 20.00 Example 6 7: 3 70 ° C / 3min 11.05 25.90 17.00 19.88 Example 7 6: 4 25 ° C / 3 min 11.46 10.30 25.70 26.18 Example 8 6: 4 70 ° C / 3min 11.12 15.70 19.80 24.90 Example 9 5: 5 25 ° C / 3 min 10.58 15.90 19.20 22.10 Example 10 5: 5 70 ° C / 3min 10.87 18.90 17.20 20.60 Comparative Example Silicon only - 4.50 150.00 10.50 6.60

As shown in Table 1, the polyurethane foam dressings of Examples 1 to 10 according to the present invention are both excellent in absorbency, absorption rate, peel strength, and probe tack. When the weight ratio of the polyurethane adhesive and the silicone adhesive is 6 : 4, and Example 7, which was cured at 25 占 폚 for 3 minutes, has the best physical properties.

* Adhesive layer peel test

The peelability of the adhesive layer of the polyurethane foam dressing having improved tackiness according to the present invention was examined.

Test method: After the polyurethane foam dressing was applied to the skin for 2 hours, the polyurethane foam dressing was peeled off and the remaining layer of the adhesive layer of the polyurethane foam dressing was photographed. Currently available polyurethane foam dressing is purchased and tested as a comparative example.

Fig. 1 is a photograph of peeling test from the skin of Comparative Example, and Fig. 3 is a photograph of peeling test from the skin of Example 7. Fig.

As shown in FIGS. 1 and 3, the polyurethane foam dressing of the comparative example shows that the adhesive remains on the skin. In the case of the polyurethane foam dressing of Example 7 according to the present invention, the remaining adhesive does not transfer to the skin .

Polyurethane foam: 100 Adhesion layer: 200
Release film: 300

Claims (8)

A polyurethane foam for dressing formed from a polyurethane foam, an adhesive layer and a release film,
The pressure-sensitive adhesive layer is composed of a polyurethane pressure-sensitive adhesive and a silicone pressure-sensitive adhesive, each of which is formed by mixing 1: 9 to 9: 1 by weight,
Wherein the polyurethane adhesive is synthesized from a polyether polyol and an isocyanate. ≪ RTI ID = 0.0 > 8. < / RTI > The method according to claim 1,
Wherein the adhesive layer is formed by mixing a polyurethane adhesive and a silicone adhesive at a weight ratio of 6: 4 to 4: 6. The method according to claim 1,
Wherein the polyurethane pressure-sensitive adhesive is of the liquid type. The method of claim 3,
Wherein the polyurethane adhesive is a curing agent and a two-component type of a curing agent, wherein the curing agent is a prepolymer formed from a polyether polyol and an isocyanate, and the subject is a polyether polyol ≪ / RTI > polyurethane foam dressing. The method according to claim 1 or 4,
Wherein the polyether polyol has a weight average molecular weight of 5000 to 8000. The polyurethane foam dressing according to claim 1, The method according to claim 1,
Wherein the polyurethane adhesive is a one-pack type polyurethane foam dressing. The method according to claim 1,
Wherein the silicone adhesive is a one-pack type polyurethane foam dressing. The method according to claim 1,
Wherein the silicone pressure sensitive adhesive is of the liquid type.

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