KR101479206B1 - Functional nanofibrous mat based on nanofiber patterning and its fabrication method - Google Patents

Abstract

Disclosed is a functional nanofiber mat comprising a first nanofiber scanned and formed in one direction by using an electrospinning method; and a second nanofiber which intersects with the first nanofiber and is formed to have a constant angle with the first nanofiber, wherein the first nanofiber and the second nanofiber are alternately arranged; each layer forms constant thickness; the first nanofiber and the second nanofiber are made of different polymer materials; and the first nanofiber or the second nanofiber is a functional layer. The nanofiber mat of the present invention generates a pattern by scanning a nanofiber in a specific position, thereby controlling mechanical properties which existing nanofiber mats do not have, and having higher availability than an existing method as a material can be located in the specific position.

Description

TECHNICAL FIELD [0001] The present invention relates to a functional nanofiber mat based on a nanofiber pattern and a method for manufacturing the nanofiber mat.

The present invention relates to a functional nanofiber mat based on a nanofiber pattern and a method of manufacturing the functional nanofiber mat. More particularly, the present invention relates to a functional nanofiber mat which can impart mechanical and material functions by providing a nanofiber mat having a specific pattern. Nanofiber mat and a method of manufacturing the same.

Nanofibers produced by the electrospinning process are attracting much attention in various fields such as energy (fuel cell membrane), environment (filter, desalination), biotechnology (tissue engineering, cell culture) Is becoming a subject of high interest.

This is because the nanostructured nanofibers are similar to the fibrous structure of the extracellular matrix (ECM) inside the human body, and their size is similar to that of other materials. Thus, it is possible to obtain a more effective cell culture quality in culturing the cells. In addition, by including the drug in the nanofibers, they are gradually released to affect the cells, thereby inducing the cell culture in a specific direction or enhancing the culture efficiency And various other effects can be obtained.

In recent years, Nanofiber Solutions has commercialized mats that can be used in well plates or dishes for the purpose of universally utilizing these nanofibers in cell culture. In addition, nanofibers are generally obtained at the laboratory level by individual electrospinning and cell culture. Much improvement is required in the use of such a mat.

Conventional nanofibers are generally integrated in one direction and integrated in a certain direction using a drum that is integrated or rotated on an integrated plate. When the fibers are integrated in an arbitrary direction, since there is no directionality of the fibers, it is difficult to orientate them in a specific direction, and there is a lack of controllability on the integrated position, so that a specific substance (e.g., a fluorescent substance and a biochemical substance) It is difficult to integrate the nanofibers including the nanofibers.

Electrospinning using rotating drum showed very good performance for alignment of nanofibers, but there was no controllability of nanofiber aggregation position. Accordingly, the aligned nanofiber mat may enhance the mechanical properties in the alignment direction, but it is difficult to add other complicated features.

Recently, various applications using nanofibers have been announced. Typical examples include a polymer membrane of a fuel cell, a photoelectrode of a solar cell, a scaffold in a tissue engineering, a cell sheet, and a skin patch. However, their geometrical quality is limited.

SUMMARY OF THE INVENTION The present invention has been made to solve the above problems of the prior art,

It is an object of the present invention to provide a functional nanofiber mat capable of providing directionality in a specific direction and capable of enhancing mechanical properties suitable for the intended use by accumulating a specific substance in a specific position.

It is another object of the present invention to provide a method for producing a functional nanofiber mat capable of providing orientation in a specific direction and enhancing mechanical properties suitable for the intended use by integrating and incorporating a specific substance at a specific position, We will do it.

In order to solve the above problems,

A first nanofiber formed by scanning in one direction using an electrospinning process; And

And a second nanofiber crossing the first nanofiber and formed at a predetermined angle with the first nanofiber,

Wherein the first nanofibers and the second nanofibers are alternately laminated, wherein each layer forms a uniform thickness, the first nanofibers and the second nanofibers are made of polymer materials different from each other, and the first nano- The functional nanofiber mat is characterized in that the fiber or the second nanofiber is a functional layer.

In order to solve the above-mentioned other problems,

A first nanofiber formed in a plurality of layers by scanning in one direction using an electrospinning process; And

And a second nanofiber formed in a plurality of layers at an angle with the first nanofiber,

Wherein the first nanofiber and the second nanofiber are made of a polymer material different from each other, and the first nanofiber or the second nanofiber is a functional layer.

In order to solve the above-mentioned other problems,

Scanning in one direction in a zigzag form at a point of time using an electrospinning process, scanning a predetermined distance vertically from the end point of the one direction and scanning in the opposite direction of the one direction,

A functional nanofiber mat having a comb-like pattern by forming a plurality of laminated structures without crossing each other, characterized in that the mat is flexible until a linear pattern is formed and has a rigidity after a linear pattern is formed Lt; / RTI >

In order to solve the above-mentioned other problems,

Forming a first nanofiber formed by scanning in one direction using an electrospinning process; And

And forming a second nanofiber crossing the first nanofiber and forming a predetermined angle with the first nanofiber,

Wherein the first nanofibers and the second nanofibers are alternately laminated, wherein each layer forms a uniform thickness, the first nanofibers and the second nanofibers are made of polymer materials different from each other, and the first nano- Wherein the fiber or the second nanofiber is a functional layer.

In order to solve the above-mentioned other problems,

Scanning in one direction using an electrospinning process to form a plurality of first nanofibers; And

Forming a plurality of second nanofibers having a predetermined angle with the first nanofibers,

Wherein the first nanofiber and the second nanofiber are made of a polymer material different from each other and the first nanofiber or the second nanofiber is a functional layer.

In order to solve the above-mentioned other problems,

A first step of scanning in one direction in a zigzag form at a time point using an electrospinning process;

A second step of vertically moving a predetermined distance from the end point of the one direction and scanning the opposite direction of the one direction; And

A method for manufacturing a functional nanofiber mat having a comb-shaped pattern by repeating the first and second steps and forming a plurality of laminated structures without crossing each other.

The nanofiber mat of the present invention can control the mechanical properties of existing nanofiber mat by scanning the nanofibers at a specific position to generate a pattern, and the material can be positioned at a specific position, Respectively.

The mechanical properties can be controlled by varying the angle of the comb teeth so that the stiffness can be varied according to the amount of the strain. The material exhibiting piezoelectric characteristics can be used as an actuator and a power plant. In this case, High efficiency can be obtained by the characteristic of the directionality.

In addition, due to uniform thickness and density, it is easy to apply the fuel cell to a uniform thickness / density mat with uniform and improved quality. In the case of integrating different materials at a specific point, it is advantageous to connect the various kinds of tissues in the tissue engineering field to enhance the selective growth quality and to induce the reaction of the cells on the matte.

FIG. 1 shows a configuration of a direct-write electrospinning (DWES) device used in the manufacture of a mat according to an embodiment of the present invention.
2 shows an example of a mat manufacturing process using raster scan according to an embodiment of the present invention.
Figure 3 shows the mechanical stiffness of a mat manufactured according to one embodiment of the present invention.
FIG. 4 is a cross-sectional view of a general polymer according to an exemplary embodiment of the present invention. FIG. 4 is a cross-sectional view of a functional polymer according to an embodiment of the present invention.
FIG. 5 shows that nanofibers containing different drugs may be radiated according to positions of mats according to an embodiment of the present invention, and cell growth may be different depending on positions.
FIG. 6 shows that the functional nanofiber mat prepared according to an embodiment of the present invention has mechanical properties such that the stiffness is small in the initial deformation through the scanning in the direction of the comb, but the stiffness suddenly increases after the comb is opened have.
FIG. 7 shows various comb patterns of the functional nanofiber mat prepared according to the present invention.

DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of the present invention will now be described with reference to the accompanying drawings. The embodiments described below can be modified into various forms, and the scope of the present invention is not limited to the following embodiments. The embodiments of the present invention are provided to clearly convey the technical idea of the present invention to a person having ordinary skill in the art.

The present invention relates to a first nanofiber formed by scanning in one direction using an electrospinning process; And a second nanofiber crossing the first nanofiber and formed at an angle with the first nanofiber, wherein the first nanofiber and the second nanofiber are alternately stacked, Wherein the first nanofiber and the second nanofiber are made of a polymer material different from each other and the first nanofiber or the second nanofiber is a functional layer, .

FIG. 1 shows a structure of a direct-write electrospinning (DWES) device used for manufacturing a mat according to an embodiment of the present invention. FIG. 2 is a schematic view showing a mat production process using a raster scan according to an embodiment of the present invention As shown in FIG.

The nanofibers were fabricated by using nanofibers (DWES) and nanofibers. The nanofibers were fabricated by functionalized nanofibers (NdFe) A mat can be manufactured.

First, patterning is performed through nanofiber scanning using a direct irradiation electrospinning process. In this case, the conditions may vary depending on the polymer to be used, and a solution is prepared by mixing the first nanofiber polymer material with a solvent (for example, chloroform) with an appropriate concentration, more preferably 5.0 to 10.0 wt% The voltage is in the range of 15 to 40 KV, the distance between the nozzle and the integrating plate is 3 to 8 cm, the inner diameter of the nozzle is 100 to 500 μm, and the thickness of the glass integrating plate is 100 to 200 μm. The diameter of the side electrode of the cylinder type is preferably 10 to 20 cm. The flow rate is preferably 0.05 to 0.2 ml / h.

Direct scanning The scanning speed of the electrospinning device can be varied and its size can vary from 0 to 500 mm / s, where the width of the linear pattern of nanofibers is inversely proportional to the scanning speed. The minimum line pattern width is equal to the diameter of the nanofibers.

The nanofiber pattern can be generated through scanning according to the designed shape, and the thickness can be adjusted by repeating the scanning in the same path. In order to produce a mat having a uniform thickness, a nanofiber mat having a uniform thickness and density can be manufactured using a raster scan pass having a pitch smaller than the line width determined in the process conditions.

The electrospun nanofibers can be bonded to each other through heat treatment and crosslinking process so that the fibers are stuck to each other to increase the rigidity.

According to an embodiment of the present invention, the first nanofiber may include a first nanofiber and a second nanofiber formed at a predetermined angle with the first nanofiber. Wherein the first nanofiber and the second nanofiber are made of a polymer material different from each other, and the first nanofiber and the second nanofiber are alternately laminated, wherein each of the layers forms a uniform thickness, Can form a functional layer.

The second nanofibers are stacked on the same plane at a predetermined distance to form a plurality of functional layers. The second nanofiber can be obtained by spinning nanofibers containing a functional drug.

The first nanofiber and the second nanofiber may be formed to cross each other, and the first nanofiber and the second nanofiber may be orthogonal to each other.

The first nanofiber may be selected from the group consisting of polycaprolactone (PCL), polyethylene, polypropylene, polystyrene, polyethylene terephthalate, polyether sulfone, polyvinylidene fluoride, cellulose, nylon, polycarbonate, polyurethane, Or a copolymer thereof.

The second nanofiber may be formed by spinning a piezoelectric polymer material. The second nanofiber is preferably any one selected from polypyrrole, polypyrrolidone, polyvinyl alcohol, and polyvinylidene fluoride (PVDF).

The first nanofiber and the second nanofiber may be repeated to form a layer, and the repeating layer may be formed of two to 100 layers.

Figure 3 shows the mechanical stiffness of a mat manufactured according to one embodiment of the present invention. 3 shows experimental results of the mechanical stiffness of the functional nanofiber mat comprising 10 layers, 30 layers, and 50 layers. It was found that the mechanical stiffness was excellent at 50 layers rather than 30 layers and 30 layers rather than 10 layers . As the number of layers increases, the mechanical stiffness and fracture strength increase but the total strain energy decreases.

The functional drug may include a substance that induces bone growth and a substance that induces muscle growth, so that the mat may form a scaffold. Preferably, examples of the functional drug include a growth factor, basic-FGF (bFGF), bone morphogenetic protein (BMP), heparin or fucoidan.

According to another embodiment of the present invention, there is provided a nanofiber comprising: a first nanofiber formed in a plurality of layers by scanning in one direction using an electrospinning process; And a second nanofiber formed in a plurality of layers at a predetermined angle with the first nanofiber, wherein the first nanofiber and the second nanofiber are made of polymer materials different from each other, and the first nanofiber or the first nanofiber And the 2-nanofiber is a functional layer.

The second nanofibers are stacked on the same plane at a predetermined distance to form a plurality of functional layers as described above.

The types of the first nanofiber and the second nanofiber are the same as those in which the first nanofiber and the second nanofiber are formed to cross each other.

The present invention provides a method for fabricating a semiconductor device, comprising: forming a first nanofiber formed by scanning in one direction using an electrospinning process; And forming a second nanofiber crossing the first nanofiber and formed at a predetermined angle with the first nanofiber, wherein the first nanofiber and the second nanofiber are alternately stacked, Wherein the first nanofiber and the second nanofiber are made of a polymer material different from each other and the first nanofiber or the second nanofiber is a functional layer. Of the present invention.

The present invention provides a method for fabricating a semiconductor device, comprising: forming a first nanofiber formed in a plurality of layers by scanning in one direction using an electrospinning process; And forming a plurality of second nanofibers having a predetermined angle with the first nanofibers, wherein the first nanofibers and the second nanofibers are made of polymer materials different from each other, Wherein the nanofiber or the second nanofiber is a functional layer.

In order to have specific directionality or mechanical properties by using two or more materials, the function may be given according to the integration path of the given electrospun nanofibers for each material. First, a polymer (for example, polycaprolactone or polystyrene) that is common to the first nanofiber is radiated by lateral raster scanning and integrated, and a polymer having piezoelectric properties as a second nanofiber on the first nanofiber (e.g., polypyrrole, PVA ) Is subjected to the raster scanning in the longitudinal direction, a mat having features that extend in the longitudinal direction under an electric field can be formed.

Figure 3 shows the mechanical stiffness of a mat manufactured according to one embodiment of the present invention. Referring to FIG. 3, it can be seen that the mechanical strength is improved as the thickness is increased by repeating the lamination.

FIG. 4 is a cross-sectional view of a general polymer according to an embodiment of the present invention. FIG. 4 is a cross-sectional view of a piezoelectric polymer according to another embodiment of the present invention. At this time, the lower end shows a process of scanning a general polymer in the horizontal direction and scanning the longitudinal direction of the functional polymer (for example, the piezoelectric polymer) to give the piezoelectric function in the longitudinal direction.

A thick general polymer at the bottom and a thick piezoelectric polymer at the top may have a deformation mode such as bimetallic if they are integrated in this manner through repetition. At the time of intersection repetition, it can be an overall stretched plate shape.

FIG. 5 shows that nanofibers containing different drugs may be radiated according to positions of mats according to an embodiment of the present invention, and cell growth may be different depending on positions.

By placing the functional drug at the desired position, the growth of the cells can be made different, which can be applied in various ways. For example, when making artificial scaffolds that connect to various tissues in tissue engineering (eg ligament connects bone and muscle), one of them is a substance that induces bone growth, and the other a substance that induces muscle growth Spun into nanofibers to form scaffolds that can be connected to both tissues. Or to include other materials (attractant for specific cells) at different positions on the mat, a functional nanofiber mat capable of moving various cells toward the inducer can be produced.

According to another aspect of the present invention, there is provided an electro-optical device, comprising: an electro-spinning process which scans in one direction in a zigzag form at a time point, moves vertically at a predetermined distance in the one direction, A functional nanofiber mat having an interdigitated comb shape by repeatedly forming a plurality of laminated structures without crossing each other, characterized in that the mat is flexible until a linear pattern is formed, and after forming a linear pattern, . By controlling the angle of the comb, mechanical properties can be controlled.

The present invention relates to a method of manufacturing a semiconductor device, comprising: a first step of scanning in one direction in a zigzag form at a time point using an electrospinning process; A second step of vertically moving a predetermined distance from the end point of the one direction and scanning the opposite direction of the one direction; And repeating the first and second steps to form a plurality of laminated structures without crossing each other, thereby providing a method of manufacturing a functional nanofiber mat having a comb-like pattern.

FIG. 6 shows that the functional nanofiber mat prepared according to an embodiment of the present invention has mechanical properties such that the stiffness is small in the initial deformation through the scanning in the direction of the comb, but the stiffness suddenly increases after the comb is opened have.

Referring to FIG. 6, when a nanofiber is scanned and integrated with a comb pattern, the mat is very flexible due to deflection, not tensile, until the direction of the comb is straightened at the time of pulling, And can have a relatively high rigidity / rigidity behavior, and can have two kinds of mechanical properties. In this way, when adjusting the angle of the comb or the like, the rigidity at the time of tension can be adjusted.

FIG. 7 shows various comb patterns of the functional nanofiber mat prepared according to the present invention. The mechanical properties can be controlled by varying the angle of the comb teeth so that the stiffness can be varied according to the amount of the strain. The material exhibiting piezoelectric characteristics can be used as an actuator and a power plant. In this case, High efficiency can be obtained by the characteristic of the directionality.

According to the present invention, a functional nanofiber mat can be utilized for various purposes such as a fuel cell having a uniform thickness / density mat with a uniform and improved quality due to uniform thickness and density. In the case of integrating different materials at a specific site, in the field of tissue engineering, it is possible to increase the selective growth quality compared to the conventional one and to induce the reaction of the cells on the matte.

Claims (21)

A first nanofiber layer arranged and formed in a first direction using an electrospinning process; And a second nanofiber layer arranged in a second direction crossing the first nanofiber layer and forming a certain angle with the first direction,
Wherein the first nanofibers and the second nanofibers are alternately stacked so that each of the layers forms a uniform thickness and the second nanofibers are stacked on the same plane with a predetermined distance therebetween, Characterized in that the second nanofiber layer has different mechanical stiffness according to fiber orientation,
Wherein the first nanofiber and the second nanofiber are formed of a polymer material that is different from each other, wherein the second nanofiber is formed by spinning a piezoelectric polymer, a temperature sensitive material, or a humidity sensitive material, Wherein the nanofiber layer exhibits piezoelectric functionality, temperature responsive functionality or humidity responsive functionality.
A functional nanofiber mat having a plurality of nanofiber layers with different mechanical stiffness.
delete The method according to claim 1,
Wherein the second nanofiber is obtained by spinning nanofibers including a functional drug.
The method according to claim 1,
Wherein the first direction and the second direction are orthogonal to each other.
delete The method according to claim 1,
Wherein the first nanofiber layer and the second nanofiber layer are repeated to form a layer, and the repeating layer is formed of two to 100 layers.
The method of claim 3,
Characterized in that the mat forms a scaffold due to the functional drug.
The method according to claim 1,
Wherein the first nanofiber is selected from the group consisting of polycaprolactone (PCL), polyethylene, polypropylene, polystyrene, polyethylene terephthalate, polyethersulfone, polyvinylidene fluoride, cellulose, nylon, polycarbonate, polyurethane, polyacrylate, And a copolymer thereof. ≪ / RTI >
The method according to claim 1,
Wherein the second nanofiber is any one selected from the group consisting of polypyrrole, polypyrrolidone, polyvinyl alcohol, and polyvinylidene fluoride (PVDF).
A first nanofiber layer formed by scanning the first nanofibers in one direction using an electrospinning process to form a plurality of layers, the first nanofibers being arranged in a first direction; And a second nanofiber layer formed in a plurality of layers, wherein the second nanofibers are arranged in a second direction intersecting with the first nanofiber layer and forming a certain angle with the first direction,
The first nanofiber layer and the second nanofiber layer have different mechanical stiffnesses depending on the fiber orientation, and the first nanofiber layer and the second nanofiber layer have different mechanical stiffnesses depending on the fiber orientation,
Wherein the first nanofiber and the second nanofiber are formed of a polymer material that is different from each other, wherein the second nanofiber is formed by spinning a piezoelectric polymer, a temperature sensitive material, or a humidity sensitive material, Wherein the nanofiber layer exhibits piezoelectric functionality, temperature responsive functionality or humidity responsive functionality.
A functional nanofiber mat having a plurality of nanofiber layers with different mechanical stiffness.
delete 11. The method of claim 10,
Wherein the second nanofiber is obtained by spinning nanofibers including a functional drug.
delete 13. The method of claim 12,
Wherein the functional drug comprises a substance inducing bone growth and a substance inducing muscle growth, whereby the mat forms a scaffold.
11. The method of claim 10,
Wherein the first nanofiber is selected from the group consisting of polycaprolactone (PCL), polyethylene, polypropylene, polystyrene, polyethylene terephthalate, polyethersulfone, polyvinylidene fluoride, cellulose, nylon, polycarbonate, polyurethane, polyacrylate, And a copolymer thereof. ≪ / RTI >
11. The method of claim 10,
Wherein the second nanofiber is any one selected from the group consisting of polypyrrolidone, polyvinyl alcohol, and polyvinylidene fluoride (PVDF).
The first nanofibers are scanned in a zigzag shape in one direction at a starting point using an electrospinning process and are moved vertically at a predetermined distance from the end point of the one direction and are moved in a zigzag Scanning is performed repeatedly,
A nanofiber mat having a comb-like shape by forming a plurality of laminated structures without crossing each other,
The nanofiber mat is characterized in that it has two mechanical properties that are flexible until a linear pattern is formed and exhibit mechanical rigidity after a linear pattern is formed, and the mechanical properties can be controlled by adjusting the angle of the comb Functional nanofiber mat.
delete delete delete delete

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