KR101421623B1 - Apparatus for Testing Inhalation Toxicity of Organic Solvent Gas based on spray way - Google Patents

Abstract

The present invention relates to a device for testing organic solvent gas suction toxicity, wherein organic solvent gas is generated and provided to an exposing chamber by means of a technique in which a liquid organic solvent is atomized and evaporated using collision energy. The organic solvent gas can be easily generated even though heated energy is supplied through a separate heat source, so that energy efficiency is improved. The organic solvent gas can be generated at room temperature so that the organic solvent is not coagulated while being provided to the exposing chamber. Therefore, a larger amount of the organic solvent gas can be effectively supplied, and a more accurate suction toxicity test can be possible. A separated trap device is mounted so as to remove the liquid organic solvent included in an aerosol form in the organic solvent gas provided to the exposing chamber, so that the organic solvent gas can be supplied in a pure manner. Accordingly, the supplied amount of the organic solvent gas can be more accurately controlled, so that the accuracy of test results can be improved.

Description

TECHNICAL FIELD [0001] The present invention relates to an organic solvent gas inhalation toxicity test apparatus using spraying method,

The present invention relates to an organic solvent gas inhalation toxicity test apparatus. More specifically, the organic solvent gas is generated by atomizing a liquid organic solvent by impinging energy and then supplied to the exposure chamber, thereby easily generating an organic solvent gas without supplying heating energy through a separate heat source And the organic solvent gas can be generated at room temperature. As a result, the condensation phenomenon does not occur during the supply of the organic solvent gas to the exposure chamber, so that more supply amount can be efficiently supplied. Accordingly, more accurate inhalation toxicity test The organic solvent gas can be supplied in a more pure state by mounting a separate trap device to remove the liquid organic solvent contained in the liquid aerosol state in the organic solvent gas supplied to the exposure chamber, Accordingly, the supply amount of the organic solvent gas can be more accurately You can control relates to an organic solvent gas inhalation toxicity test apparatus which can improve the accuracy of the results.

In general, various kinds of organic solvents are used in the industrial field. When the organic solvent evaporates in a closed space where there is almost no air and the surrounding place, organic solvent poisoning is caused by flowing into the body through the respiratory and skin of the worker.

When such an organic solvent is introduced into the body, anesthesia occurs at a high concentration and at a low concentration, nervous symptoms such as insomnia, anxiety, and headache appear.

In addition, since each of the solvents has its specific toxicity, if the organic solvent having high toxicity is absorbed into the human body through the skin or respiratory tract, it can cause the poisoning of the organic solvent which causes the nerve, respiratory, digestive and various organs. In manufacturing and handling workplaces, it is obligatory to install various safety facilities such as ventilators and to wear protective gear.

However, in actual industrial sites, these safety obligations are often not observed due to inconvenience, leading to frequent human accidents.

Inhalation toxicity studies on such organic solvents are generally conducted in a manner that exposes the test substances to experimental animals for a certain concentration and period of time to evaluate their harmfulness.

Inhalation toxicity studies for organic solvents are based on the assessment of skin toxicity by skin absorption or respiration, the calculation of the Lethal Concentration of 50 Percent Kill (LC50), which is an indicator of toxicity, and the exposure standard for securing the safety of the working environment , Research on the carcinogenicity of malignant tumors, study of in vivo behavior of inhaled substances, prediction of toxicity and study of human disease models, study of respiratory system, especially structure and function of lungs. And it is very important as a field of industrial toxicity research for predicting health disorders due to the handling of chemicals in the working environment and for identifying the cause of diseases.

Despite the high importance of toxicological studies on organic solvents, the technology for inhalation toxicity testing equipment for organic solvents has been very limited to the present.

As a prior art, there is Korean Patent No. 10-678448.

The present invention has been made to solve the problems of the prior art, and it is an object of the present invention to provide an apparatus and a method for generating organic solvent gas by supplying an organic solvent gas to the exposure chamber in such a manner as to atomize a liquid organic solvent by impact energy, It is possible to easily generate the organic solvent gas without supplying the heating energy through the heat source of the organic solvent gas to improve the energy efficiency and to generate the organic solvent gas at room temperature, The present invention provides an organic solvent gas inhalation toxicity test apparatus capable of supplying a large amount of supply efficiently and thereby enabling a more accurate inhalation toxicity test.

It is another object of the present invention to provide an apparatus and a method for supplying organic solvent gas in a pure state by mounting a separate trap device to remove liquid organic solvent contained in a liquid aerosol state in an organic solvent gas supplied to an exposure chamber, And an object of the present invention is to provide an apparatus for inspecting an organic solvent gas inhalation toxicity which can control the supply amount of the organic solvent gas more accurately and improve the accuracy of a test result.

The present invention relates to a gas generating unit for vaporizing a liquid organic solvent and generating it in a gaseous state; And an exposure chamber connected to the gas generating unit through a separate connection pipe for introducing the organic solvent gas generated from the gas generating unit into the internal space, Wherein the organic solvent gas is generated by atomizing a liquid organic solvent to evaporate the organic solvent gas.

The gas generating unit may include a storage container in which a liquid organic solvent is accommodated in an inner space; A main flow path formed at an upper end of the main flow path and connected to the connection pipe, and a jet flow path communicating with the main flow path so as to collide with the inner side surface of the main flow path, A main body including a suction passage communicated with the injection passage in a direction crossing the main passage; And a control unit that controls the suction passage and the inner space of the storage container so that the liquid organic solvent accommodated in the storage container is sucked and ejected together with the clean air due to a pressure drop phenomenon generated during the process of injecting the clean air through the injection passage, And the liquid organic solvent is injected together with the clean air, collides with the inner surface of the main flow path, is atomized, and evaporates and is discharged through the discharge port.

In addition, a separate recovery pipe may be connected to the lower end of the main flow path so that the non-evaporated, liquid organic solvent falls due to its own weight and can be recovered to the storage container.

In addition, a spray plate having a nozzle hole formed at a central portion thereof may be detachably coupled to the injection path so that the clean air can be injected at a high pressure.

In addition, a trap device may be mounted on the connection pipe so as to remove the liquid organic solvent contained in the organic solvent gas passing through the connection pipe.

In addition, the trap device may include a trap housing having inlet and outlet portions at both ends thereof and communicating with the connection pipe; A first chamber communicating with the inlet and a second chamber communicating with the outlet; and a second chamber communicating with the first chamber and the second chamber at a lower end of the trap chamber, And a separator formed on the substrate.

Further, a separate drain pipe may be mounted on the lower end of the trap housing and connected to the storage container.

An air flow rate regulator is installed in the injection path of the main body so as to adjust the supply flow rate of the clean air and a concentration of the organic solvent gas in the exposure chamber is adjusted by controlling the supply flow rate of the clean air through the air flow rate controller. As shown in FIG.

According to the present invention, the organic solvent gas is generated and supplied to the exposure chamber in such a manner that the liquid organic solvent is atomized by the collision energy and evaporated, thereby easily generating the organic solvent gas without supplying the heating energy through the separate heat source So that the organic solvent gas can be generated at room temperature. As a result, the condensation phenomenon does not occur during the supply to the exposure chamber, so that more supply amount can be efficiently supplied. As a result, more accurate inhalation toxicity This has the effect of enabling testing.

Further, by installing a separate trap device to remove the liquid organic solvent contained in the liquid aerosol state in the organic solvent gas supplied to the exposure chamber, the organic solvent gas can be supplied in a more pure state, The supply amount of the gas can be more accurately controlled and the accuracy of the test result can be improved.

1 is a conceptual diagram conceptually showing a configuration of an organic solvent inhalation toxicity test apparatus according to an embodiment of the present invention;
2 is a conceptual diagram schematically showing a configuration of a gas generating unit according to an embodiment of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the drawings, the same reference numerals are used to designate the same or similar components throughout the drawings. In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

FIG. 1 is a conceptual diagram conceptually showing a configuration of an apparatus for testing an organic solvent inhalation toxicity according to an embodiment of the present invention, and FIG. 2 is a conceptual diagram schematically showing a configuration of a gas generating unit according to an embodiment of the present invention .

An apparatus for testing an inhalation toxicity of organic solvent according to an embodiment of the present invention is an apparatus for performing an inhalation toxicity test by exposing an organic solvent gas in a state of vaporizing a liquid organic solvent to an experimental animal, And a chamber (300).

The gas generating unit 100 is a device for generating liquid organic solvent Q in a gaseous state and is configured to generate organic solvent gas G in such a manner that the liquid organic solvent Q is atomized and evaporated do. That is, unlike a general organic solvent gas generating apparatus, a liquid organic solvent Q is atomized by simply spraying a liquid organic solvent Q instead of vaporizing a liquid organic solvent through heating by a heater And can be vaporized at room temperature.

The gas generating unit 100 may include a storage container 110, a main body 120, and a suction pipe 130, as shown in FIG.

The storage container 110 may be formed in the form of a spherical container so that the liquid organic solvent Q is received in the internal space. The discharge port 124 of the main body 120, which will be described later, (200). In the interior of the storage container 110, liquid organic solvent (Q) is stored so as to fill only a part of the space, and vaporized organic solvent gas exists in the remaining space.

The main body 120 is disposed in an inner space of the storage container 110 and is spaced apart from the liquid organic solvent Q stored in the storage container 110. The main body 120 has a main passage 121, a spray passage 122, and a suction passage 123 formed therein. The main flow path 121 is vertically formed in the main body 120. The discharge port 124 is formed at an upper end of the main flow path 121. The discharge port 124 is connected to a separate connection pipe 200 to the exposure chamber 300. The injection path 122 communicates with the main flow path 121 in a direction intersecting with the inner surface of the main flow path 121 by injecting high-pressure clean air. The suction passage 123 communicates with the injection passage 122 and the suction pipe 130 is connected to the lower end of the suction passage 123.

The main flow path 121 may be formed in the vertical direction and the injection path 122 may be formed in the horizontal direction communicating with the main flow path 121 and the suction path 123 may be formed in the vertical direction communicating with the injection path 122, It is preferable that the diameter is smaller in the order of the main flow path 121, the injection path 122, and the suction path 123.

A separate air inflow pipe 125 is connected to the injection path 122 so as to supply clean air and a flow rate of the clean air introduced through the air inflow pipe 125 is adjusted in front of the air inflow pipe 125 An air flow regulator 150 may be mounted. A second air filter 160 for filtering the air may be mounted on the upstream side of the air flow regulator 150 and the second air filter 160 may be mounted on the second air filter 160 as shown in FIG. The HEPA filter 161 and the activated carbon 162 may be arranged in such a manner that the HEPA filter 161 and the activated carbon 162 sequentially filter the air.

1 and 2, a jet plate 126 having a nozzle hole 127 formed at its center so that clean air introduced through the air inlet pipe 125 can be injected at a high pressure is formed on the inlet side of the jet flow path 122, And it may be coupled with the air inlet pipe 125 in a detachable form from the injection path 122. [ The ejection plate 126 is detachably coupled to the ejection plate 126, so that the ejection plate 126 having a different type of nozzle hole 127 can be easily replaced, thereby controlling the injection pressure of the clean air.

One end of the suction pipe 130 is connected to the lower end of the suction passage 123 and the other end is connected to the liquid organic solvent Q stored in the storage container 110.

2, when the clean air is injected at high pressure along the injection path 122, a pressure drop phenomenon occurs in the injection path 122 in this process. By this pressure drop phenomenon, Liquid organic solvent Q contained in the storage container 110 is sucked toward the injection path 122 along the suction path 130 and the suction path 123. [ The liquid organic solvent Q sucked into the injection path 122 is injected toward the main flow path 121 together with the clean air. In this injection process, the liquid organic solvent Q is primarily atomized. Thereafter, the liquid organic solvent Q injected toward the main flow path 121 collides with the inner surface of the main flow path 121 at a high speed by the jet pressure, and is secondarily atomized into a finer shape by the impact energy. Since the liquid organic solvent Q is easily vaporized and vaporized in this manner, the organic solvent gas G generated in this manner is discharged to the outside through the discharge port 124 of the main flow path 121. A separate connection pipe 200 is coupled to the discharge port 124 and connected to the exposure chamber 300.

The exposure chamber 300 is connected to the exhaust port 124 through the connection pipe 200 so that the organic solvent gas G is introduced from the gas generating unit 100, The solvent gas (G) flows into the exposure chamber (300) through the connection pipe (200).

The exposure chamber 300 is formed so that the laboratory animal 600 is inserted into the inner space and the laboratory animal 600 is able to suck the organic solvent gas G introduced therein. That is, the organic solvent gas G introduced into the exposure chamber 300 is exposed to the laboratory animal 600 and is sucked into the laboratory animal through the breath of the laboratory animal 600. Since this exposure chamber 300 can be applied to a known type used in an inhalation toxicity test apparatus for nanoparticles and the like, a detailed description thereof will be omitted.

The suction pump 400 is configured to be communicatively coupled to the exposure chamber 300 to suck the internal space of the exposure chamber 300. By the operation of the suction pump 400, a negative pressure is formed in the inner space of the exposure chamber 300, so that the organic solvent gas G can be smoothly introduced.

According to the above-described structure, the organic solvent gas sucking toxicity test apparatus according to an embodiment of the present invention is a device for inspecting the organic solvent gas sucking ability of the liquid organic solvent (Q) by simply spraying clean air without heating the liquid organic solvent (Q) The organic solvent gas G can be easily generated. Particularly, since the organic solvent gas (G) is generated in a normal temperature state without heating the liquid organic solvent (Q), not only the energy efficiency is high but also the temperature of the organic solvent gas (G) The condensation due to the temperature difference does not occur during the process of supplying the organic solvent gas G to the exposure chamber 300, so that the organic solvent gas G can be supplied more efficiently.

On the other hand, the liquid organic solvent Q injected through the injection path 122 is atomized and evaporated in the process of colliding with the inner surface of the main flow path 121. In this case, when the size of the atomized particles is relatively large Evaporation is not easily accomplished and may remain in an atomized liquid aerosol state. The liquid aerosol particles Q1 are bonded to each other and can grow and return to a liquid state. The organic solvent Q1, which is relatively heavy or kept in a liquid state, It is preferable that a separate recovery pipe 128 is connected to the lower end of the main flow path 121. The recovery pipe 128 may be disposed so as to be submerged in the liquid organic solvent (Q) contained in the storage container 110 or not to be locked.

In addition, as described above, the air flow rate regulator 150 is installed in the injection path 122 to adjust the supply flow rate of the clean air. The apparatus for testing the organic solvent gas inhalation toxicity according to one embodiment of the present invention, And adjust the concentration of the organic solvent gas (G) supplied to the exposure chamber 300 through adjustment of the supply flow rate of the clean air through the regulator 150. Accordingly, the concentration of the organic solvent gas G can be easily controlled by adjusting the air flow regulator 150 without providing a separate valve or the like on the connection pipe 200, Unlike the manual operation of the valve, the control can be conveniently configured with an automatic control method.

Meanwhile, the organic solvent gas discharged through the discharge port 124 of the main flow path 121 may contain some organic solvent in a liquid aerosol state. Therefore, according to one embodiment of the present invention, the connection pipe 200 is provided with a separate trap device 210 (not shown) to remove the organic solvent in the liquid aerosol state contained in the organic solvent gas G passing through the connection pipe 200 Can be mounted.

The trap device 210 includes a trap housing 211 formed at both ends thereof with an inlet 212 and an outlet 213 communicating with each other on the connection pipe 200 and an inner space of the trap housing 211 And a second chamber C2 communicating with the outlet 213. The first chamber C1 and the second chamber C2 are installed at the lower end of the first chamber C1 and the second chamber C2, And a separation plate 214 in which a flow hole 215 is formed so as to communicate with each other.

According to this configuration, since the organic solvent gas G flowing through the connection pipe 200 to the exposure chamber 300 is relatively light, the organic solvent gas G flows along the separation plate 214 as shown in an enlarged view of FIG. The organic solvent in the relatively heavy liquid aerosol state collides against the separator plate 214 and loses flow energy to the bottom of the trap housing 211 So that it can no longer move along the connection pipe 200. Accordingly, in the lower space of the trap housing 211, the organic solvent in the liquid aerosol state is condensed and stored in the liquid state.

A separate discharge pipe 220 is installed at the lower end of the trap housing 211 so that the organic solvent stored in the liquid state in the trap housing 211 can be returned to the storage container 110, Can be configured to be connected. The organic solvent in the liquid phase is once again removed through the trap device 210 and is recovered to the storage container 110 so that the supply efficiency of the organic solvent gas G supplied to the exposure chamber 300 is further improved.

The connection pipe 200 is connected to the exposure chamber 300 and is formed to have a length such that liquid organic solvent Q can be vaporized during transfer from the gas generating unit 100 to the exposure chamber 300, A vaporizer may be formed between the generating unit 100 and the exposure chamber 300 to induce vaporization of the liquid organic solvent Q passing through the connection pipe 200.

The foregoing description is merely illustrative of the technical idea of the present invention and various changes and modifications may be made by those skilled in the art without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are intended to illustrate rather than limit the scope of the present invention, and the scope of the technical idea of the present invention is not limited by these embodiments. The scope of protection of the present invention should be construed according to the following claims, and all technical ideas falling within the scope of the same shall be construed as falling within the scope of the present invention.

100: gas generating unit 110: storage container
120: main body 121: main flow path
122: injection channel 123: suction channel
124: exhaust port 125: air inlet pipe
126: jet plate 127: nozzle hole
128: recovery pipe 130: suction pipe
150: Air flow regulator 200: Connection piping
210: trap device 211: trap housing
214: separation plate 220: discharge pipe
300: Exposure chamber 400: Suction pump
600: Experimental animal

Claims (8)

delete A gas generating unit for vaporizing a liquid organic solvent and generating the gas in a gaseous state; And
And an exhaust chamber connected to the gas generating unit through a separate connection pipe for introducing the organic solvent gas generated from the gas generating unit into the internal space,
Wherein the gas generating unit generates an organic solvent gas in such a manner that the liquid organic solvent is atomized and evaporated,
The gas generating unit
A storage container in which a liquid organic solvent is accommodated in an inner space;
A main flow path formed at an upper end of the main flow path and connected to the connection pipe, and a jet flow path communicating with the main flow path so as to collide with the inner side surface of the main flow path, A main body including a suction passage communicated with the injection passage in a direction crossing the main passage; And
The suction passage and the inner space of the storage container are arranged such that the liquid organic solvent accommodated in the storage container is sucked and ejected together with the clean air due to a pressure drop phenomenon generated during the process of injecting the clean air through the injection passage, Connecting pipe
Wherein the liquid organic solvent is injected together with the clean air, collides with the inner side surface of the main flow path, is atomized, and evaporates and is discharged through the discharge port.
3. The method of claim 2,
Wherein the main flow channel is connected to a separate recovery pipe at the lower end so that the non-evaporated liquid organic solvent falls due to its own weight and can be recovered to the storage container.
3. The method of claim 2,
Wherein the spray plate is detachably coupled to a spray plate having a nozzle hole formed at its center so that the clean air can be injected at a high pressure.
5. The method according to any one of claims 2 to 4,
Wherein a trap device is mounted on the connection pipe so as to remove an atomized liquid organic solvent contained in the organic solvent gas passing through the connection pipe.
6. The method of claim 5,
The trap device
A trap housing having inlet and outlet portions at both ends thereof and communicating with the connection pipe; And
A first chamber communicating with the inlet portion and a second chamber communicating with the outlet portion; and a flow hole formed at a lower end of the trap chamber so that the first chamber and the second chamber communicate with each other Separating plate
Wherein the organic solvent gas inhalation toxicity test apparatus comprises:
The method according to claim 6,
And a separate drain pipe is attached to the lower end of the trap housing and connected to the storage container.
5. The method according to any one of claims 2 to 4,
An air flow rate regulator is installed in the injection path of the main body so as to adjust the supply flow rate of the clean air and a concentration of the organic solvent gas in the exposure chamber is adjusted by controlling the supply flow rate of the clean air through the air flow rate controller. Wherein the organic solvent gas inhalation toxicity test apparatus comprises:

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