KR101401193B1 - Soft capsule coating - Google Patents

Abstract

(A) carrageenan, (B) oxidized starch and / or bleached starch, and (C) a plasticizer.

Description

Soft capsule coating < RTI ID = 0.0 >

The present invention relates to a soft capsule shell and a method for producing a soft capsule using the same.

Soft capsules are used in a wide range of fields such as medicine, food, and cosmetics. The most commonly used capsules for soft capsules are gelatin, and gelatin is inexpensive, non-toxic, and exhibits excellent mechanical strength, film-forming ability and the like.

On the other hand, for reasons of bovine spongiform encephalopathy (BSE) or religious reasons, an alternative to animal-derived gelatin is required, and capsules are no exception.

Therefore, various studies have been made on capsule capsules using a plant-derived base, and for example, a film-forming composition containing a chemical starch such as starch octenyl succinate sodium with carrageenan and corn syrup solids added thereto, a plasticizer and water A film forming composition for soft capsules containing a composition for capsules containing carrageenan and dextrins (Patent Literatures 2 and 3), acid-decomposed waxy cornstarch, iota-carrageenan, and a plasticizer (Patent Document 1) (Patent Document 5), and the like have been reported as a composition for a coating film containing hydroxypropylated dextrin, oxidized starch, gelling agent, plasticizer and water.

In general, soft capsule coatings are required to have appropriate fluidity, good film forming property, appropriate sheet strength, elongation, adhesiveness, and the like of the coating solution at the time of production, and also, after encapsulation, , Elasticity, transparency, and the like are required. However, it has been a reality that a vegetable coating having such a comprehensive coating performance has not been found yet.

JP 2005-529066 A JP 2005-176744 A JP 2009-173607 A JP 2010-180159 A JP 2008-88111 A

SUMMARY OF THE INVENTION The present invention has been made in view of the above-described conventional circumstances, and an object of the present invention is to provide a method for producing a soft capsular capsule and a soft capsule, which have good fluidity, film formability and excellent coating performance.

As a result of various studies to solve the above problems, the inventors of the present invention have found that when carrageenan and oxidized starch or bleached starch are combined, they have appropriate fluidity for the coating liquid, good film formability, . Further, when the soft capsule is manufactured from such a coating liquid by using a rotary die soft capsule filling machine, the film sheet is heated in advance and encapsulated by pressing the film sheet without heat sealing, The soft capsule can be produced continuously over a long period of time, thus completing the present invention.

That is, the present invention relates to the following 1 to 29.

1. A soft capsule shell comprising (A) carrageenan, (B) oxidized starch and / or bleached starch, and (C) a plasticizer.

2. The soft capsule shell according to 1 above, wherein (A) the carrageenan is a mixture of iota carrageenan and kappa carrageenan.

3. The soft capsule coating film according to 2 above, wherein the content of iota carrageenan is 8 to 40% by mass of the total amount of the solid components.

4. The soft capsule film according to 2 above, wherein the content of iota carrageenan is 10 to 30% by mass in the total amount of solid components.

5. The soft capsule coating according to 2 above, wherein the content of iota carrageenan is 15 to 20% by mass in the total amount of the solid components.

6. The soft capsule film according to any one of 2 to 5 above, wherein the content of kappa carrageenan is 0.1 to 0.8% by mass in the total amount of solid components.

7. The soft capsule film according to any one of 2 to 5 above, wherein the content of kappa carrageenan is 0.3 to 0.8% by mass in the total amount of solid components.

8. The soft capsule coating according to any one of 2 to 5 above, wherein the content of kappa carrageenan is 0.4 to 0.7% by mass in the total amount of the solid components.

9. The soft capsule coating according to any one of the above 2 to 8, wherein the mass ratio of the content of iota carrageenan to kappa carrageenan is 400: 1 to 10: 1.

10. The soft capsule film according to any one of 2 to 8 above, wherein the mass ratio of iota carrageenan to kappa carrageenan is 133: 1 to 10: 1.

11. The soft capsule shell according to any one of 2 to 8, wherein the mass ratio of iota carrageenan to kappa carrageenan is 75: 1 to 21: 1.

12. The soft capsule coating according to any one of 1 to 11 above, wherein the content of the oxidized starch and / or the bleached starch (B) is 60 to 90 mass% in the total amount of the solid components.

13. The soft capsule coating according to any one of 1 to 11 above, wherein the content of the oxidized starch and / or the bleached starch (B) is 70 to 80% by mass in the total amount of the solid components.

14. The soft capsule coating according to any one of 1 to 13, wherein the coating further comprises one or more standardization substances selected from the group consisting of sucrose, glucose, maltose, lactose and dextrin.

15. A process for preparing soft capsule shell liquid comprising (A) carrageenan, (B) oxidized starch and / or bleached starch and (C) plasticizer,

Forming a pair of film sheets by rolling the soft capsule film liquid on the pair of rotating drums,

And a step of sending the pair of film sheets between a pair of rotating dies, the method comprising:

Wherein the pair of film sheets is heated to a temperature higher than room temperature until reaching a pair of rotating molds and the film sheet is pressed at room temperature without heating the segments disposed on the top of the mold The method of producing a soft capsule according to claim 1,

16. The production method of the soft capsule as described in 15 above, wherein the heating of the coating sheet is carried out by heating the rotary drum at 30 to 80 占 폚.

17. The method of producing a soft capsule as described in 15 above, wherein the heating of the coating sheet is carried out by heating the rotary drum at 40 to 75 占 폚.

18. The method according to any one of the above 15 to 17, wherein (A) the carrageenan is a mixture of iota carrageenan and kappa carrageenan.

19. The process for producing a soft capsule as described in 18 above, wherein the content of iota carrageenan is 8 to 40 mass% of the total amount of the solid ingredients.

20. The process for producing a soft capsule as described in 18 above, wherein the content of iota carrageenan is 10 to 30 mass% of the total amount of solid components.

21. The process for producing a soft capsule as described in 18 above, wherein the content of iota carrageenan is 15 to 20 mass% of the total amount of the solid components.

22. The process for producing a soft capsule according to any one of 18 to 21, wherein the content of kappa carrageenan is 0.1 to 0.8 mass% of the total amount of the solid components.

23. The process for producing a soft capsule according to any one of the above 18 to 21, wherein the content of kappa carrageenan is 0.3 to 0.8% by mass in the total amount of solid components.

24. The process for producing a soft capsule according to any one of 18 to 21, wherein the content of kappa carrageenan is 0.4 to 0.7% by mass in the total amount of solid components.

25. The soft capsule film according to any one of the above 18 to 24, wherein the mass ratio of the content of iota carrageenan to kappa carrageenan is 400: 1 to 10: 1.

26. The process for producing a soft capsule according to any one of the above 18 to 24, wherein the mass ratio of contained iota carrageenan and kappa carrageenan is 133: 1 to 10: 1.

27. The process for producing a soft capsule according to any one of 18 to 24, wherein the mass ratio of the content of iota carrageenan to kappa carrageenan is 75: 1 to 21: 1.

28. The production method of soft capsules according to any one of items 15 to 27, wherein the content of oxidized starch and / or bleached starch (B) is 60 to 90 mass% of the total amount of solid components.

29. The production method of soft capsules according to any one of the above items 15 to 27, wherein the content of the oxidized starch and / or bleached starch (B) is 70 to 80% by mass in the total amount of the solid components.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to stably provide a soft capsule excellent in coating performance such as blocking resistance, elasticity and transparency without using gelatin derived from an animal.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a view showing an example of a rotary die soft capsule filling machine. Fig.

The carrageenan (A) used in the present invention is a kind of galactan having a sulfate group, and is known to exist in red seaweeds. Carrageenan can be classified into three types mainly of Iota carrageenan, kappa carrageenan, and Lambda carrageenan due to the difference in gelation characteristics and structure. In addition, in the Japanese food additives regulation, three kinds of "refined carrageenan", "Eucheuma algae" and "Yukemasa jomon" are prescribed (between Japan Food Additives Association, (1999)), they are all different in puri fi cation scheme and are essentially all included in carrageenan in the present invention.

In the present invention, from the viewpoint of the gelation ability, it is preferable to use iota carrageenan or kappa carrageenan, and it is particularly preferable to use a mixture of iota carrageenan and kappa carrageenan. The carrageenan may be either a pure product or a standard product. Here, examples of the standardization substance include one or more selected from the group consisting of sugars such as sucrose, glucose, maltose, lactose, and dextrin. Preferably, it is sucrose, dextrin. As the dextrin, acid-decomposed dextrin and enzyme-decomposed dextrin are preferable. In addition, the dextrin referred to herein is a substance different from cyclodextrin, maltodextrin ("decomposition proceeds more slowly than dextrin" (Chemical Society, 8, 897, co-

In addition, brand raw materials pre-mixed with Iota carrageenan and kappa carrageenan are available.

The content of iota-carrageenan is preferably from 8 to 40% by mass, more preferably from 10 to 30% by mass, particularly preferably from 15 to 20% by mass, based on the total amount of solid components in terms of film strength and fluidity of the coating solution desirable. In the present invention, the solid component excludes purified water and a plasticizer in the film composition. The content of kappa carrageenan is preferably 0.1% by mass or more, more preferably 0.3% by mass or more, and more preferably 0.8% by mass or less from the viewpoint of the film strength (vulnerability) in the total amount of solid components in terms of gelation strength . And more preferably 0.4 to 0.7 mass%.

In the present invention, the mass ratio of contained iota carrageenan and kappa carrageenan (iota: kappa) is in the range of 400: 1 to 10: 1 in terms of comprehensive viewpoint (film strength, fluidity of the film solution, More preferably 75: 1 to 21: 1 (30: 0.4 to 15: 1), more preferably 40: 0.1 to 8: 0.7) is preferable.

The oxidized starch (B) used in the present invention is a starch obtained by oxidizing starch with an oxidizing agent. It is also assumed that the starch is subjected to thermochemical treatment with an acid, an oxidizing agent, or the like to obtain a low viscosity self-modified starch.

The oxidized starch is preferably not subjected to a chemical treatment other than the oxidation treatment, for example, acid treatment, alpha-oxidation, etherification, or acetylation. It has been found that the starch to which acetylated chemical is applied is not suitable as a result of examination (Test Example 13 described later).

The bleached starch (B) used in the present invention is a starch in which the color tone of starch is adjusted by oxidizing other coloring matter components without chemically modifying the starch. In the present invention, each of oxidized starch and bleached starch may be used individually, or two or more kinds of oxidized starch and bleached starch may be appropriately mixed.

There is no particular limitation on the kind of the starch to be provided in the oxidation treatment and the like, and for example, unmodified starch such as corn starch, waxy corn starch, tapioca starch, potato starch, sugarcane starch, wheat starch and the like can be mentioned. Two or more kinds of starch mixtures may be oxidized.

The oxidizing agent is not particularly limited and includes, for example, alkali metal hypochlorite such as sodium hypochlorite; Alkaline earth hypochlorite such as calcium hypochlorite; alkali metal chlorite such as sodium hypochlorite and potassium hypochlorite; And alkaline earth metal chlorides such as barium chlorite and the like.

The carboxy content of the oxidized starch or the bleached starch is preferably 1.1% by mass or less, more preferably 0.8% by mass or less. The amount of carboxy in the starch is determined by the method described in the Ministry of Health, Labor and Welfare Notice No. 485 (October 20, 2008 (October 1, 2008), pp. 28 to 35 of the Ministry of Health, Labor and Welfare (e-government web page = http: //search.e. -gov.go.jp/servlet/PcmFileDown

(2) "carboxyl group" in the item of "Purity Test" on pages 6-7 of "Attachment" published in "Load? seqNo = 0000035986"

In the present invention, the content of the oxidized starch and / or the bleached starch (B) is preferably 90% by mass or less in the total amount of the solid components in terms of the film sheet strength, 60% More preferably 80% by mass.

The plasticizer (C) used in the present invention is not particularly limited, and examples thereof include glycerin, sorbitol, propylene glycol, and polyethylene glycol. Among them, glycerin is preferable. The plasticizer in the soft capsule coating preferably contains 30 to 60 parts by mass, particularly 40 to 50 parts by mass, of the total amount of the solid components as 100 parts by mass from the viewpoint of flexibility.

The soft capsule coating of the present invention may optionally contain various additives used for the capsule coating such as a coloring agent such as a natural colorant, a synthetic colorant, a light shielding agent and various sweeteners, a preservative, a stabilizer, A stabilizer and the like.

The soft capsule coating of the present invention may optionally contain a gelling agent other than carageenan such as sodium alginate, pullulan, glucomannan, gum arabic, furcellaran and the like; Starch such as unmodified starch, starch chemical starch, and starch hydrolyzate and bleaching starch. However, in view of the physical properties of the capsule and the quality of the soft capsule, gelling agents other than carrageenan, oxidized starch, Is preferably 1 mass% or less, more preferably 0.5 mass% or less, particularly 0 mass%, of the total amount of the solid components.

The soft capsule coating can be prepared by a conventional method. For example, carrageenan, oxidized starch and / or bleached starch, a plasticizer and, if necessary, various additives may be stirred and dispersed in water, stirred and dissolved at 90 to 98 캜, and then defoamed under vacuum.

The pH of the coating liquid (100-fold diluted solution, 70 캜) is preferably 6.0 to 8.0.

The soft capsule shell is obtained by molding and drying the soft capsule shell into a predetermined shape. The soft capsule can be produced, for example, by a conventional method of producing a soft capsule, for example, a punching method using a rotary die soft capsule filling machine or the like, a flat plate method or the like. Among them, from the viewpoint of industrial productivity, it is preferable to produce by rotary die casting.

The rotary die soft capsule filling machine is a method of punching two film sheets formed by rolling the soft capsule film liquid on a rotating drum into a pair of rotating molds (die rolls) in a capsule shape, Charging of the capsule contents is carried out simultaneously.

Fig. 1 shows an example of a rotary multi-function capsule filling machine used in the present invention. The rotary type portable soft capsule filling machine 10 mainly comprises a rotating drum 13, a pair of rotating molds (die rolls) 16, and a segment 17. First, the soft capsule shell liquid is supplied from the tank 11, and is cast on the rotary drum 13 by the casting apparatus 12 to form the film sheet A. A pair of film sheets A are formed in the same manner.

A pair of film sheets A are fed between a pair of rotating molds (die rolls) 16 via a lubricating roller 14 and a deflectrol roll 15, The capsule contents B fed by the piston 18A of the pump 18 interlocked with the die roll 16 are pressed into the space between the film sheets A which are sandwiched by the molds (die rolls) The concave portion 16A of the mold (die roll) 16 is provided with a depression and the periphery of the depression is pressed by the periphery of the concave portion 16A. Immediately before the depression of the film sheet (A) is completely closed, the capsule contents (B) are pressed into the depressions. Subsequently, the periphery of the concave portion 16A is completely closed to form the soft capsule, and punching of the soft capsule C is performed by the press of the die (die roll) 16.

Normally, the soft capsule coating liquid forms a pair of sheets by rolling over a pair of cooled rotating drums, and at the time of capsule forming, the soft capsule coating liquid is placed on the upper part of a pair of rotating molds (die rolls 16) (Usually 40 DEG C or higher) necessary for the adhesion by the segments 17 provided on the surface of the substrate 10, and the adhesive surface becomes a complete soft capsule by the pressure of the die roll and the heat sealing. However, since the capsule contents may be exposed to high temperatures during heat sealing for encapsulation, there is a possibility that the capsule contents are denatured. Therefore, in the present invention, the pair of coated sheets are heated at a temperature higher than normal temperature, for example, 30 to 80 캜, It is preferable to heat the film sheet at a temperature of -75 占 폚, pass between a pair of rotating dies (die rolls), and capsulate the film sheet by pressing at room temperature (22 to 28 占 폚) without heating the segments. By heating the coated sheet in advance, the mechanical strength of the coated sheet and the adhesive force at the time of pressing are improved, and a higher quality soft capsule can be formed. By avoiding the heat sealing, the content of the capsule can be protected from heating, and for example, a drug with low heat resistance can be encapsulated.

The heating of the film sheet can be carried out, for example, by heating the rotary drum at 30 to 80 캜, preferably at 40 to 75 캜, a heating device such as blowing an infrared heater or hot air between the rotating drum and the mold And heating it. The film sheet may be heated to a temperature higher than room temperature between the pair of rotary molds by molding, and may be lowered to room temperature when the rotary mold is reached.

The soft capsule of the present invention can be used for various uses such as medicines, quasi drugs, food, cosmetics and the like, and the composition of the contents of the capsule is appropriately determined according to the use. The form of the contents may be any of a solution form, a suspension form, a paste form, a powder form, a granule form and the like. The soft capsules are packaged in the form of packaging such as bottle packing, PTP package, pouch, etc. and stored and distributed.

Example

Hereinafter, the present invention will be described concretely with reference to examples, but the present invention is not limited thereto.

For Examples 1 to 3, the following materials were used as raw materials.

Iota Carrageenan: 20% by mass of standardized substance (sucrose) manufactured by CP KERKO. ※

Kappa carrageenan: 100% by mass product of Mitsubishi Shoji Food &

Oxidized starch: " Stabiose ", a product of Matsuya Kagaku Kogyo K.K., a carboxyl group content of 0.8 mass% or less

Glycerin: manufactured by Sakamoto Yakuhin Kogyo Co., Ltd., food additive grade *

Each prescribed amount of " Iota carrageenan " described in the treatment column of each test example was described in an amount not containing the standardized substance.

Example 1; Preparation of soft capsules according to the plate method

(1) Manufacturing method A

The gelling agent, starch and glycerin in the amounts (parts by mass) shown in Table 1 were each stirred and dispersed in water, dissolved at 90 to 95 캜 with stirring, and defoamed in vacuo. This coating liquid was spread uniformly over the stainless steel plate to a thickness of about 1 mm by using an applicator for a thin layer chromatograph and cooled at about 15 캜 for 2 minutes to obtain a film sheet on the film. (At this stage, the following evaluation was made: (a) evaluation of the strength of the film sheet (b) evaluation of stretching of the film sheet s).

The resulting coated sheet was encapsulated in a state in which the frame was warmed using a flat tabletting type capsule device to form a soft capsule (Test Examples 1 to 6). (At this stage, [c. Evaluation of the adhesion of the film sheet immediately after the capsule formation was carried out].

This soft capsule was stored in a desiccator adjusted to a relative humidity of 20% or less for 24 hours to obtain a dry soft capsule. (Evaluation of Elasticity of Capsules after Drying, Evaluation of Adhesiveness of Capsules after Drying, and Evaluation of Transparency of Capsules after Drying) were carried out at this stage.

In this test, it is assumed that the film sheet is cooled on the rotary drum and heating is carried out in the segment as in the conventional case.

(2) Production method B

The gelling agent, starch and glycerin in the amounts (parts by mass) shown in Table 1 were each stirred and dispersed in water, and then dissolved at 90 to 95 캜 with stirring and defoamed in vacuo. The coating liquid was spread uniformly over the stainless steel plate to a thickness of about 1 mm using an applicator for a thin layer chromatograph, and heated at about 60 DEG C for 2 minutes to obtain a film-coated film sheet. (At this stage, the following evaluation was made: (a) evaluation of the strength of the film sheet (b) evaluation of elongation of the film sheet).

The thus obtained coated sheet was subjected to encapsulation operation at room temperature without warming the mold using a flat plate simple capsule device to form a soft capsule (Test Example 7). (At this stage, [c. (Evaluation of Adhesion of Polypropylene)

This soft capsule was stored in a desiccator adjusted to a relative humidity of 20% or less for 24 hours to obtain a dry soft capsule. (Evaluation of Elasticity of Capsules after Drying, Evaluation of Adhesiveness of Capsules after Drying, and Evaluation of Transparency of Capsules after Drying) were carried out at this stage.

In this test, it is assumed that the film sheet is heated on the rotary drum and the segments are heated at room temperature.

[Evaluation of Strength of Coating Sheet]

The strength of the coated sheet was evaluated according to the evaluation criteria shown below by the sense of five professional panels.

5: Very strong

4: Strong

3: slightly strong

2: Weak

1: very weak

[B. Evaluation of elongation of film sheet]

 At the time of evaluation of the strength of the coated sheet by the sense of five professional panels, the elongation of the coated sheet was evaluated according to the following evaluation criteria at the same time.

5: Very stretched and resilient

4: stretched, resilient

3: Stretched, but slightly resilient

2: little stretching, weak elasticity

1: No stretching, no elasticity

[C. Evaluation of Adhesion of Coating Sheet Immediately After Capsule Formation]

Encapsulation was carried out according to the following production method (A) or preparation method (B), and the capsule before drying was pressed with five professional panels by a finger to evaluate the adhesiveness of the coated sheet immediately after the capsule formation, Respectively.

5: Even if pressed strongly, the liquid does not come out completely, and even if left for 24 hours, no leaching occurs in all capsules.

4: The liquid does not come out even if it is pressed strongly, but when it is left for 24 hours, some capsules leach out.

3: Extremely small amount of content liquid leaks when pressed hard

2: A small amount of liquid is spilled even when pressed lightly

1: Leakage of contents even when pressed lightly

[D. Evaluation of Elasticity of Capsules after Drying]

The deformation when the capsule was pressed with a finger was observed with five professional panels, and the elasticity of the capsule was evaluated according to the following evaluation criteria.

5: Do not deform, or even slightly deformed, then return to the original shape

4: Press to change slightly, but if you leave for a while, return to the original form

3: Press to deform, it takes time to return to its original shape

2: Press to deform, mostly do not return to original

1: Pressing does not return to the original state when deformed

E. Evaluation of the adhesion of the capsules after drying]

The capsules were placed in a glass bottle with five professional panels to observe whether they dropped or not, and the adhesiveness of the capsules was evaluated according to the following evaluation criteria.

5: Just by inverting the glass bottle, the capsule drops out of the hood

4: When the glass bottle is turned upside down and shaken gently, the capsule is dropped

3: When the glass bottle is turned upside down and the capsule is dropped

2: If you throw the glass bottle upside down, you will barely lose the capsule.

1: The capsule is strongly attached to the glass bottle

[F. Evaluation of transparency of the capsules after drying]

Five professional panels were visually observed to evaluate the transparency of the capsules according to the following evaluation criteria.

5: Equivalent to gelatinous film

4: Almost equal to gelatinous coating

3: slightly behind the gelatin capsule

2: Close to printing glass

1: Equal to printing glass

From Table 1, it was found that the soft capsule coating of the present invention has soft capsules excellent in coating performance and in good quality (Test Examples 1 and 2). On the other hand, in Test Examples 3 to 6 using starch other than oxidized starch and Test Example 7 using native gellan gum as a gelling agent, there were difficulties in physical properties of the coating, and the elasticity and adhesion after encapsulation were poor.

Example 2

Manufacture of Soft Capsule by Rotary Diverse Soft Capsule Charger

(1) Carrageenan, starch, and glycerin in the amounts (parts by mass) shown in Table 2 were each stirred and dispersed in water, dissolved at 90 to 98 캜 with stirring, and defoamed in vacuo. From this coating liquid, a soft capsule was prepared using the rotary-type flexible soft capsule filling machine 10 shown in Fig. First, the coating liquid was fed to a rotating drum at 45 캜 by a casting apparatus to prepare a coating sheet. The temperature of the film sheet at this time was 45 占 폚. The properties (strength, elongation, adhesion) of each of the coated sheets were evaluated in the same manner as in Example 1. [

(2) Then, the two obtained sheet sheets were passed between a pair of rotating cylindrical dies via lubricating rollers and diplex rollers, respectively, and the segments were encapsulated at room temperature (22 to 28 캜) without heating Soft capsules were obtained (Test Examples 8 to 18). The temperature of the film sheet in the vicinity of the rotary mold was about 29 占 폚. The elasticity, adhesiveness, and transparency of the soft capsule were evaluated in the same manner as in Example 1. The results are shown in Table 2.

From Table 2, it was found that the soft capsule coating of the present invention had soft capsules excellent in coating performance and in good quality (Test Example 8). On the other hand, in Test Examples 9-11 and 16 in which unmodified starch and the like were used, the viscosity of the coating liquid was high and the mechanical strength was insufficient to encapsulate it. Further, in Test Example 13 using the acetylated oxidized starch, the pH of the coating liquid was low and the capsule could not be encapsulated.

In Test Examples 12, 14-15 and 17-18 using acid-treated waxy cornstarch and the like, it was particularly difficult to elongate and adhere to the coating film, resulting in poor elasticity and adhesion after encapsulation, and the quality of the soft capsule was not sufficient.

Example 3

(1) In the same manner as in Example 2, a coating liquid was prepared in accordance with the prescription shown in Table 3, and then a film sheet was prepared using the rotary-type soft capsule filling machine 10. The properties (strength, elongation, adhesion) of each of the coated sheets were evaluated in the same manner as in Example 1. [

(2) Soft capsule was produced continuously from the obtained two sheet sheets in the same manner as in Example 2 for 120 minutes (Test Examples 20 to 25). The temperature of the film sheet in the vicinity of the rotary mold was about 29 占 폚. The elasticity, adhesiveness, and transparency of the soft capsule were evaluated in the same manner as in Example 1. The results are shown in Table 3.

From Table 3, it was found that the soft capsule coating of the present invention had soft capsules excellent in coating performance and in good quality (Test Examples 19-24). Further, it was confirmed that no problems were caused at all during continuous operation for 120 minutes, and the soft capsule could be stably produced continuously for a long time.

Example 4

The following materials were used.

Iota Carrageenan: 40% by mass of standardized substance (sucrose) manufactured by CP KERKO.

Iota Carrageenan: 40% by mass of standardized substance (dextrin) manufactured by MSC.

Kappa carrageenan: 100% by mass product of Mitsubishi Shoji Food &

Oxidized starch: " Stabiose ", a product of Matsuya Kagaku Kogyo K.K., a carboxyl group content of 0.8 mass% or less

Glycerin: manufactured by Sakamoto Yakuhin Kogyo Co., Ltd., food additive grade *

Each prescribed amount of " Iota carrageenan " described in the treatment column of each test example was described in an amount not containing the standardized substance.

(1) In the same manner as in Production Process B of Example 1, a coating liquid was prepared by the formulation shown in Table 4 to obtain a film-coated film sheet. The properties (strength, elongation) of each of the coated sheets were evaluated in the same manner as in Example 1.

(2) The resulting coated sheet was encapsulated at room temperature without warming the frame using a flat-type simple capsule device to form soft capsules (Test Examples 25 to 32). The adhesion of the coated sheet, the elasticity of the soft capsule, the adhesion, and the transparency were evaluated in the same manner as in Example 1. The results are shown in Table 4.

From Table 4, it was found that the soft capsule coating of the present invention has soft capsules excellent in coating performance and in good quality (Test Examples 25, 26, 31 to 32). On the other hand, in Test Example 27 in which the unmodified starch was used, the viscosity of the coating liquid was high, and the mechanical strength was insufficient and the capsule could not be encapsulated. In Test Examples 28 to 30 using acid-treated waxy cornstarch and the like, it was difficult to elongate the coating film in particular, and thus the quality of the soft capsule was not sufficient.

10: Rotary die-cast soft capsule charger, 11: Tank,
12: casting device, 13: rotary drum,
14: Lubricating roller, 15: Diffrelectrol,
16: a pair of rotating molds (die roll), 16A: concave part of mold (die roll)
17: segment, 18: pump,
18A: piston, A: coated sheet,
B: the content of the capsule, and C: the soft capsule.

Claims (14)

A soft capsule shell containing (A) carrageenan, (B) oxidized starch, bleached starch or mixed starch thereof, and (C) glycerin, wherein said carrageenan is a mixture of iota carrageenan and kappa carrageenan, The content of kappa carrageenan is 0.1 to 0.8 mass% in the total amount of the solid components, the mass ratio of contained iota carrageenan to kappa carrageenan is 75: 1 to 21: 1, (B) the content of oxidized starch, bleached starch, And 60 to 90 mass% of the total amount of solid components. delete delete delete delete delete delete Preparing a soft capsule shell liquid containing (A) carrageenan, (B) oxidized starch, bleached starch or mixed starch thereof, and (C) glycerin,
Forming a pair of film sheets by rolling the soft capsule film liquid on the pair of rotating drums,
And a step of sending the pair of film sheets between a pair of rotating dies, the method comprising:
(A) the carrageenan is a mixture of iota carrageenan and kappa carrageenan, the content of kappa carrageenan is 0.1 to 0.8 mass% of the total amount of solid components, and the mass ratio of iota carrageenan to kappa carrageenan is 75: 1, and the content of the oxidized starch, the bleached starch or the mixed starch thereof in the total amount of the solid component (B) is 60 to 90 mass%
Wherein the pair of film sheets is heated to 30 to 80 DEG C until reaching a pair of rotating molds, and the film sheet is pressed at room temperature without heating the segments disposed on the top of the mold The method of producing a soft capsule according to claim 1, delete delete delete delete delete delete

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