KR101381212B1 - Water tissue comprising extracts of chelidonium majus by high temperature and high pressure using hot water or thereof distillate - Google Patents

Abstract

The present invention relates to an extract of chelidonium majus extracted at high pressure and high temperature, and a water tissue containing a distillate thereof; and more specifically, to an extract of chelidonium majus extracted at a high pressure of 1.2-2.8 atm and a high temperature of 120-131°C and a water tissue containing a distillate thereof. The extract of chelidonium majus and the water tissue containing a distillate thereof can be used for skin cleansing and treating inflammatory diseases because the extract of chelidonium majus and water tissue containing the distillate thereof have excellent antibacterial and antifungal properties against pathogenic microorganisms residing on skin, and excellent inflammation inhibiting effects, cleansing effects, washing effects, disinfection effects to bug bites, atopy treating effects, and gash treating effects. [Reference numerals] (AA) (First process) Step for manufacturing an extract of chelidonium majus by mixing 100 parts by weight of chelidonium majus with 2000 to 8000 parts by weight of water and extracting chelidonium majus at a high pressure of 1.2-2.8 atm and a high temperature of 120-131째C; (BB) (Second process) Step for absorbing the extract of chelidonium majus into a fabric for a water tissue by spraying 200 to 400 parts by weight of the extract of chelidonium majus, which has been manufactured in the first process to 100 parts by weight of the fabric for a water tissue; (CC) (Third process) Step for manufacturing a water tissue containing the extract of chelidonium majus by sealing and sterilizing the fabric for a water tissue having the extract of chelidonium majus absorbed therein

Description

Water tissue comprising extracts of Chelidonium majus by high temperature and high pressure using hot water or girlfriend distillate}

The present invention relates to a wet tissue containing Baekchulchae hot-water extract or distillate thereof extracted under high temperature and high pressure conditions of 120 to 131 ° C and 1.2 to 2.8 atmospheres.

Wet tissue is used for the purpose of cleanliness and disinfection by applying water to fabrics for wet tissues such as natural pulp, cotton, inosio, tencel, natural fiber fabrics, nonwoven fabrics, synthetic fiber fabrics, and blended fiber fabrics. Oral wipes, baby wipes for cleaning, wet wipes for women, disposable wipes, multi-purpose wipes are produced in various forms, such as the use of easy and convenient wet wipes are increasing in demand. Since these products are used directly on the human skin, they must be excellent in the safety of the skin, have good removal ability against foreign substances and pathogenic microorganisms remaining on the skin, and have the functional effects and efficacy to improve the skin condition. Should be

On the other hand, currently available wet wipes usually include surfactants, chemical preservatives, fragrances and alcohols, and especially, the surfactants are prepared on the principle of dissolving foreign substances by wiping off the dirt by acting as a main component. However, these components may cause skin irritation when used on sensitive body parts. In addition, even if there is no irritation it is merely a function of wiping the skin, there is a limit to remove the bacteria adhered to the skin. In addition, methyl paraben, a chemical preservative that is harmful to health, has been detected in oral wipes that enter the mouth of babies a while ago. Eco-friendly wet tissues that do not contain chemical components are attracting attention, but the safety of these products has not been fully verified.

White-backed oysters are the genus Chelidonium Majus ) refers to the ground, and the yellow yellow latex comes out throughout the body is called celandine. The name 'Chelidonium' is derived from the Greek word Chelidon (swallow), which means swallows. When a swallowling is born, there are a lot of foreign objects in the eyes, so it cannot open its eyes. The name comes from washing. Baekgulchae is an important anti-inflammatory because it has a strong anti-inflammatory effect. The taste is very bitter and the properties are a bit warm, stop coughing, make urine come out well and have detoxification function. It is used for stomach pain, stomach cancer, jaundice, edema, scabies, social window, skin cancer, etc. It is known to be useful for the treatment of dermatitis when sterilized, diarrhea, anti-cancer activity, bitten by snakes and insects.

Moon Hyung (文 荊) refers to the outpost of horsetail ( Equisetum arvense ), a perennial herb of the vascular plant genus, and has an antioxidant effect, and has diseases such as asthma, hypertension, enteritis, eye disease, bronchial disease, osteoporosis, It is effective in treating skin diseases such as acne, athlete's foot, boils, eczema, hemostasis, anti-inflammatory, analgesic, etc., and is known to inhibit cancer cell growth. In addition, it has been reported to be excellent for removing lead accumulated in the body.

Birch tree ( Lespedeza) bicolor ) is a deciduous shrub of the dicotyledonous rosewood legume, which commonly grows in mountains. Milwon plant (원 源 植物) is used as firewood in winter. The leaves are used as feed and the bark peeled from the stem is used as a fiber resource. The newly grown stems are used for various crafts in rural areas, and they also make rain. It is distributed in Korea, Japan, China, and Ussuri River. Recently, it has been reported to have various pharmacological effects on P. alba, P. alba extract contains alkaloids, flavonoids, ascorbic acid, tannins, etc. Osteoporosis, arthritis, nephritis, kidney failure, hypertension, arteriosclerosis, conjunctivitis, eye redness It has a therapeutic effect on the back, softens and calms the skin, and is known to have a therapeutic effect on skin diseases such as freckles, blemishes, athlete's foot, ringworm, and eczema.

Yang Je-geun is a true voice of Rumex japonicus ) or the root of the same plant. Yangje (羊蹄) is named after the shape of the root resembles the hoof of sheep, and the nickname of ox tongue (牛舌) is attached to the shape of the leaf. If you boil it slightly, it can be used as a sesame. It is soft and delicious. This drug has a peculiar smell, tastes bitter, cold, and slightly poisonous. Yangje-geun is effective in turning off blood fever by acting on blood powder, nosebleeds, hemostasis, fecal bleeding, bleeding, uterine bleeding, scabies, ringworm, and constipation. Pharmacological actions have been reported to reduce blood coagulation time, inhibit skin fungi, prevent colds, inhibit leukemia and alleviate mild diarrhea. It also has a therapeutic effect on gastritis, gastric ulcer, acute enteritis, lymphadenitis, scabies, ringworm, skin disease, sores, hemorrhoids, etc., insecticide effect, detoxification effect such as snake, centipede, toad, detoxification of boil and hair dermatitis, dry Excellent antifungal action against ringworm, vulvar eczema, and itching. Appearance is long columnar, with horizontal wrinkles, and with thin roots. Root remains of stems, gray or yellowish brown on the outer side, relatively flat, yellowish brown, with dark brown lines in concentric circles.

The graft alley (木), as the name suggests, is a Chinese name that is said to be heard when the bone is broken or sprained. However, the grafts are widely distributed in Korea, in northern China, Sakhalin and Japan, and also in the West. As a medicinal herb, stems and branches of Sambucus elder, hawthorn, earthworm, and urinary tract are used to drive out wind sand, release moisture, promote blood circulation, and relieve pain. Efficacy in mitigating. Bruises, broken bones, rheumatoid arthritis, swelling, nephritis, gout, sore throat, bleeding, burns, athlete's foot, eczema, skin disease, freckles, blemishes and soothing, soften the skin, and remove wrinkles.

As a prior art, Korean Patent No. 808552 discloses a hydrogel for treating atopic dermatitis using Baekchulchae extract, and Korean Patent No. 343135 discloses that a wet tissue can be prepared using Baekchulchae extract. The prior art is different from the technical configuration of the wet tissue of the present invention containing Baekgulchae hot-water extract or distillate thereof extracted under high temperature and high pressure conditions of 120 ~ 131 ℃ and 1.2 ~ 2.8 atm.

In addition, the Korean Patent No. 1128435, the extract containing the squirt, the Korean Patent Application Publication No. 2010-0120333, the extract containing the birch, the Korean Patent No. 743205, the extract containing the sentence pattern, respectively, the composition for treating atopy Or it has been disclosed that it can be used as a cosmetic, but it is not disclosed that the composition can be used as a wet tissue, it can also be said that the invention is a technical configuration different from the present invention.

Registered Korean Patent No. 808552 (Hydration Gel for Treatment of Atopic Dermatitis, containing moisture evaporation prevention film, registered on Feb. 22, 2008) Registered Korean Patent No. 343135 (disposable natural dyeing nonwoven fabric, registered on Feb. 14, 2004) Korean Registered Patent No. 1128435 (Composition for atopy skin using naive creeper tree, docomari, oleander, and soap using the same, registered on 2012.03.13.) Korean Patent Publication No. 2010-0120333 (Atopic dermatitis improving agent using plant mixture, published on Nov. 16, 2010) Korean Registered Patent No. 743205 (Functional cosmetic composition effective for atopic dermatitis, registered on July 20, 2007)

An object of the present invention is to provide a wet tissue containing Baekchulchae hot-water extract or distillate thereof extracted under high temperature and high pressure conditions of 120 ~ 131 ℃ and 1.2 ~ 2.8 atm.

The present invention relates to a wet tissue containing baekchulchae hot-water extract extracted under high temperature and high pressure conditions of 120 ~ 131 ℃ and 1.2 ~ 2.8 atm.

The Baekgulchae hot-water extract may be prepared by mixing 2000-8000 parts by weight of water with 100 parts by weight of Baekchulchae and extracting them under high temperature and high pressure conditions of 120 to 131 ° C and 1.2 to 2.8 atmospheres.

In addition, the baekchulchae hot-water extract may be prepared by adding 1 to 50 parts by weight of one or more herbal medicines selected from the group consisting of sentence pattern, Prunus bark, Yangje-geun and Graft Alley on the basis of 100 parts by weight of baekgulchae.

The wet tissue containing the Baekchulchae hot-water extract is sprayed 200-400 parts by weight of the Baekchulchae hot-water extract on 100 parts by weight of the fabric for wet tissue to absorb the Baekhwachae hot-water extract on the fabric for wet wipes, Fabrics for absorbing wet tissues may be manufactured by hermetically packing and sterilizing.

As the fabric for the wet tissue, one selected from the group consisting of natural pulp, cotton, ingio, tencel, natural fiber fabric, blend fiber fabric, nonwoven fabric and synthetic fiber fabric can be used.

After sealing the fabric for wet wipes, it can be sterilized using a conventional sterilization method. Preferably, the sterilization may be performed under high temperature and high pressure conditions of 120 to 131 ° C. and 1.2 to 2.8 atmospheres, or by gamma irradiation for 15 to 30 hours.

In another aspect, the present invention may provide a toilet paper, cotton swab, gauze, mask, diaper, sanitary napkin and the like containing the baekchulchae hot water extract.

On the other hand,

(Step 1) mixing 2000-8000 parts by weight of water with 100 parts by weight of baekgulchae and extracting at 120-131 ° C. and 1.2-2.8 atm under high temperature and high pressure conditions to produce baekgulchae hot-water extract;

(Step 2) by spraying 200 ~ 400 parts by weight of baekchulchae hot-water extract prepared in step 1 to 100 parts by weight of the tissue for wet tissue to absorb the baekchulchae hot-water extract on the tissue for wet tissues; And

(3 step) sealing and packaging the fabric for wet tissue absorbed by the baekchulchae hot-water extract to prepare a wet tissue containing baekchulchae hot-water extract;

It can provide a wet tissue manufacturing method comprising a.

In addition, the present invention, in addition to the wet tissue manufacturing method,

(Step A) mixing 2000-8000 parts by weight of water with 100 parts by weight of baekchulchae and extracting at 120-131 ° C. and 1.2-2.8 atm of high temperature and high pressure conditions to produce baekchulchae hot-water extract;

(Step B) 100 parts by weight selected from toilet paper fabric, cotton wool, gauze fabric, cotton fabric, natural fiber fabric, synthetic fiber fabric, blended fiber fabric and nonwoven fabric, Baekgulchae hot-water extract prepared in step A Spraying 10 to 400 parts by weight to absorb baekchulchae hot-water extract;

(C step) drying one selected from toilet paper fabric, cotton wool, gauze fabric, cotton fabric, natural fiber fabric, synthetic fiber fabric, blended fiber fabric and nonwoven fabric absorbed by the baekchulchae hot water extract; And

(D process) toilet paper, cotton swab, gauze, using one kind selected from the dried toilet paper fabric, cotton wool, gauze fabric, cotton fabric, natural fiber fabric, synthetic fiber fabric, blended fiber fabric and non-woven fabric of the process C Producing, packaging and sterilizing a product selected from a mask, a diaper and a sanitary napkin; and providing a method of manufacturing a product selected from toilet paper, cotton swab, gauze, mask, diaper and sanitary napkin.

In addition, the present invention is a wet tissue, toilet paper, cotton swab, gauze, mask containing the distillate of the baekryekchae hot-water extract condensed steam obtained by distilling the hot-water extract of baekryekchae hot water extracted under high temperature and high pressure conditions of 120 ~ 131 ℃ and 1.2 ~ 2.8 atm Offers products selected from diapers and sanitary napkins.

The wet tissue containing the distillate of the baekchulchae hot-water extract,

(Step 1) mixed with 2000 ~ 8000 parts by weight of water to 100 parts by weight of baekgulchae, extract under high temperature and high pressure conditions of 120 ~ 131 ℃ and 1.2 ~ 2.8 atm to prepare a baekgulchae hot water extract, and distilled the baekgulchae hot water extract Condensing the obtained steam to prepare a distillate of Baekchulchae hot-water extract;

(Step 2) by spraying 200 ~ 400 parts by weight of the distillate of Baekgulchae hot-water extract prepared in step 1 to 100 parts by weight of the cloth for wet tissues to absorb the distillate of Baekgulchae hot-water extract on the fabric for wet tissues; And

(3 step) to seal and wrap the fabric for wet tissues in which the distillate of the baekchulchae hot-water extract is absorbed and sterilized to prepare a wet tissue containing distillate of the baekchulchae hot-water extract;

It can be prepared to include.

In addition, products selected from toilet paper, cotton swabs, gauze, masks, diapers and sanitary napkins containing the distillate of the baekgulchae hot water extract,

(Step A) 100 parts by weight of baekgulchae mixed 2000-8000 parts by weight of water and extracted under high temperature and high pressure conditions of 120 ~ 131 ℃ and 1.2 ~ 2.8 atm to prepare a baekgulchae hot-water extract, and distilled the baekgulchae hot-water extract Condensing the obtained steam to prepare a distillate of Baekchulchae hot-water extract;

(Step B) 100 parts by weight selected from toilet paper fabric, cotton wool, gauze fabric, cotton fabric, natural fiber fabric, synthetic fiber fabric, blended fiber fabric and nonwoven fabric, Baekgulchae hot-water extract prepared in step A Spraying 10 to 400 parts by weight of a distillate of absorbing the distillate of Baekchulchae hot-water extract;

(C process) drying one kind selected from toilet paper fabric, cotton wool, gauze fabric, cotton fabric, natural fiber fabric, synthetic fiber fabric, blend fiber fabric and nonwoven fabric absorbed by the distillate of Baekchulchae hot-water extract ; And

(D process) toilet paper, cotton swab, gauze, using one kind selected from the dried toilet paper fabric, cotton wool, gauze fabric, cotton fabric, natural fiber fabric, synthetic fiber fabric, blended fiber fabric and non-woven fabric of the process C Preparing, packaging and sterilizing a product selected from a mask, a diaper and a sanitary napkin;

. ≪ / RTI >

Hereinafter, the present invention will be described in detail.

The present invention relates to a wet tissue containing Baekchulchae hot-water extract or distillate thereof extracted under high temperature and high pressure conditions of 120 to 131 ° C. and 1.2 to 2.8 atm, wherein the wet tissue has an antifungal effect, an antibacterial effect, an anti-inflammatory effect, a cleaning effect, and a wash. Pharmacological effects, such as insect bite disinfection effect, atopy treatment effect.

The baekchulchae hot-water extract is prepared by mixing 2000 ~ 8000 parts by weight of water to 100 parts by weight of baekchulchae and extracted under high temperature and high pressure conditions of 120 ~ 131 ℃ and 1.2 ~ 2.8 atm, When added in less than parts by weight or added in excess of 8000 parts by weight is not preferable because the extraction efficiency is not high.

The Baekchulchae hot-water extract is an extract of the filtrate state from which the solid content (medicinal herb) is removed, and the extract may be used as it is, or may be used by concentrating it, but since the cost of the concentration process occurs, the filtrate preferably More preferably, the extract is used as it is.

In addition, when preparing the Baekchulchae hot-water extract, when extracted at a temperature and pressure conditions lower than 120 ~ 131 ℃ and 1.2 ~ 2.8 atmospheric pressure, the active ingredient is not extracted well, antifungal effect, antibacterial effect, anti-inflammatory effect, washing The effect, the washing effect, the disinfecting effect of insect bites, the atopy treatment effect, etc. are lowered and are not preferable. In addition, the active ingredient is destroyed even when extracted at temperatures and pressures higher than 120 ~ 131 ℃ and 1.2 ~ 2.8 atmospheric pressure, antifungal effect, antibacterial effect, anti-inflammatory effect, cleaning effect, cleaning effect, disinfection effect of insect bites, atopic treatment It is not preferable because the effect is lowered. In addition, the production of Baekchulchae hot-water extract at a temperature or air pressure higher than the 120 ~ 131 ℃ and 1.2 ~ 2.8 atm is not preferable because the production cost is added. However, when the extract is prepared in an ultra-high pressure state (within 1100 atm) exceeding 2.8 atm, by maintaining the extraction temperature at a low temperature of 100 ° C or less, it is possible to reduce the destruction of the active ingredient, so that the extract of Baekgulchae hot water for manufacturing wet wipes of the present invention. Can also be used as

In addition, the extraction time of the baekchulchae hot-water extract is not limited, but preferably 10 minutes to 24 hours, preferably 10 minutes to 9 hours, more preferably 10 to 60 minutes, and most preferably Preferably 20-40 minutes is good. At this time, the extraction in less than 10 minutes is not preferable because the active ingredient is not extracted well, the anti-fungal effect, antibacterial effect, anti-inflammatory effect, cleaning effect, washing effect, disinfecting effect of insect bites, atopic treatment effect is low not. If it exceeds 24 hours, the active ingredient is no longer extracted, but manufacturing costs may be added.

In addition, when one or more herbal medicines selected from the group consisting of munjok, barberry, yangjaegeun and grafting allotment are added to Baekgulchae, anti-fungal effect, antibacterial effect, anti-inflammatory effect, cleaning effect, washing effect, Pharmacological effects such as insect bite disinfection effect, atopy treatment effect can be enhanced.

The distillate of the baekgulchae hot water extract is mixed with 2000 ~ 8000 parts by weight of water to 100 parts by weight of baekgulchae condensed steam obtained by distilling the hot baekchaechae hot water extract extracted under high temperature and high pressure conditions of 120 ~ 131 ℃ and 1.2 ~ 2.8 The distillate may be obtained, in the preparation of the distillate of the baekchulchae hot-water extract, the distillation temperature can be prepared at the boiling temperature of water, but preferably 100 ~ 131 ℃, most preferably 120 ~ 131 ℃ In addition, since distillation is possible in a short time as the distillation at a high temperature, the manufacturing process is shortened.

In addition, in order to prepare the distillate of the baekchulchae hot-water extract, when producing the baekchulchae hot-water extract, based on 100 parts by weight of baekchulchae, one or more herbal medicines selected from the group consisting of Moon-shaped, Prunus chinensis, Yangje-geun and Graft Alley This may be added in 1 to 50 parts by weight.

The distillate contains volatile substances contained in the extract of baekryekchae hot water, such as antifungal effect, antibacterial effect, anti-inflammatory effect, cleaning effect, cleaning effect, disinfection effect of insect bites, atopic treatment effect, etc. The pharmacological effect is higher.

The distillate may be used by concentration, but preferably used as it is condensed steam. This may occur due to the cost of the concentration process, because the effects such as antimicrobial, anti-inflammatory, cleaning, washing, etc. are maintained enough even without concentration.

In the wet tissue of the present invention, the wet tissue product may be manufactured by a conventional process of spraying or impregnating the baekryekchae hot-water extract or distillate thereof on the fabric for wet tissue, but preferably, the spray method is better.

The wet tissue fabric may be used in one layer, but in order to enhance the use effect, a plurality of corrugated waves may be formed by thermocompression or the like in a state of overlapping in two to three layers. For example, after laminating two pieces of cloth for wet tissues, a thermal compression process may be performed to perform lattice pattern, irregularities treatment or embossing treatment.

The wet tissue of the present invention may further include components that are commonly added in addition to the baekchulchae hydrothermal extract or distillate thereof. Such additives include surfactants, moisturizers, preservatives, fragrances, bactericides, deodorants, and the like. As surfactants, dodecylbenzenesulfonate salts, lauryltrimethylammonium salts, moisturizers as chamomile oils, and phenoxy as preservatives Ethanol, methyl paraben, ethyl paraben, phenoxyethanol, herbs, green tea extract, chemomile flower extract, limonene, fungicides include ethyl alcohol, deodorant chitosan, and the like, but is not limited thereto. Components added to the product can be used. However, the wet tissue of the present invention is most preferably included only baekchulchae extract or distillate thereof. On the other hand, these additives may be added 0.01 to 5 parts by weight based on 100 parts by weight of the baekchulchae hydrothermal extract or its distillate.

On the other hand, the extraction of the high temperature and high pressure conditions in the present invention can be performed using a high temperature and high pressure extractor commonly used for extraction of herbal medicines. In addition, the spraying the white bran extract on the wet tissue may be used a steam injector, a sprayer or the like commonly used for food processing or steam injection.

In another aspect, the present invention may provide a product such as toilet paper, cotton swab, gauze, mask, diaper, sanitary napkin, etc. containing the Baekchulchae hot-water extract or distillate thereof. The products are sprayed and dried by the Baekchulchae hot-water extract or its distillate to one selected from toilet paper fabric, cotton cotton, gauze fabric, cotton fabric and non-woven fabric, respectively, toilet paper, cotton swab, gauze, mask, diaper, sanitary napkin, etc. After the manufacture of the product can be prepared by packaging and sterilization. At this time, in the case of a diaper or sanitary napkin, it is possible to manufacture an outer cover in direct contact with the skin using one selected from the cotton wool, gauze fabric, cotton fabric and non-woven fabric. In addition, as a method of sterilizing the products it is recommended to use a gamma ray sterilization method.

In the process of manufacturing products selected from toilet paper, cotton swabs, gauze, masks, diapers and sanitary napkins, selected from toilet paper fabrics, cotton wool, gauze fabrics, cotton fabrics, natural fiber fabrics, synthetic fiber fabrics, blended fiber fabrics and non-woven fabrics One 100 parts by weight, the baekgulchae hot-water extract or distillate thereof may be sprayed 10 to 400 parts by weight to absorb the baekgulchae hot-water extract or distillate thereof, wherein the baekgulchae hot-water extract or distillate thereof, The toilet paper fabric is preferably 10 to 30 parts by weight, more preferably 10 to 20 parts by weight of the cotton wool, gauze fabric, pure cotton fabric, natural fiber fabric, synthetic fiber fabric, blended fiber fabric and nonwoven fabric It is preferable to spray 100 to 400 parts by weight, more preferably 200 to 400 parts by weight to be selected.

The toilet paper may be provided in various forms such as toilet paper, beauty tissues, hand towels, kitchen towels, napkins, and the like.

On the other hand, the toilet paper containing the baekryekchae hot-water extract or distillate thereof may spray the baekryekchae hot-water extract or distillate thereof on the toilet paper fabric, the baekryekchae hot-water extract or its distillate in the step of manufacturing the toilet paper fabric The toilet paper may be added and a toilet paper is prepared by a conventional method, and a toilet paper containing Baekchulchae hot-water extract or a distillate thereof may be prepared.

In addition, the cotton bud containing the baekgulchae hot-water extract or distillate thereof, after only the cotton swab for cotton swabs treated with baekgulchae hot-water extract, you can also prepare a cotton swab, baekgulchae on the cotton swab after manufacturing a cotton swab It can also be prepared by treating hot water extract or distillate thereof.

The present invention relates to a wet tissue containing Baekchulchae hot-water extract or distillate thereof extracted under high temperature and high pressure conditions, and more specifically, Baekchulchae hot-water extract or distillate thereof extracted under high temperature and high pressure conditions of 120 to 131 ° C and 1.2 to 2.8 atmospheres. It relates to a wet tissue containing. The wet tissue containing the baekryechae hot-water extract or distillate thereof has excellent antibacterial and antifungal properties against pathogenic microorganisms on the skin, and has an anti-inflammatory effect, a cleaning effect, a washing effect, a disinfection effect of insect bites, an atopic treatment effect, a wound It is excellent in the therapeutic effect and can be easily used for improving skin cleanliness and various inflammatory diseases.

1 is a flow chart showing a method for producing a wet tissue containing Baekchulchae hot-water extract of the present invention.
Figure 2 is a flow chart illustrating a method for producing a wet tissue containing a distillate of Baekgulchae hot water extract of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein but may be embodied in other forms. Rather, the intention is to provide an exhaustive, complete, and complete disclosure of the principles of the invention to those skilled in the art.

< Example  One. White oyster Heat number  Preparation of Extracts and Distillates thereof>

Example  1-1 to 1-19. White oyster Heat number  extract

By mixing the baekchulchae and water under the conditions of Table 1 to prepare a baekchulchae hydrothermal extract under high temperature and high pressure of 120 ~ 131 ℃ and 1.2 ~ 2.8 atm (using only the liquid removed the herbal dry after extraction). In addition, in order to enhance the antimicrobial and antimicrobial effect of Baekchulchae hot-water extracts, extracts were prepared by mixing Moon-gyeobchae, Prunus vulgaris, Yangje-geun, and Graft Alley. At this time, Baekgulchae hot water extract was extracted using a high pressure and high pressure extractor (Darin machine).

Condition Weight (g) Temperature
(° C) pressure
(atmospheric pressure) time
(minute) White oyster Moon style Sycamore tree Yang Jae-geun Grafting water Example 1-1 100 - - - - 5000 120 2.0 30 Examples 1-2 100 - - - - 2000 120 2.0 30 Example 1-3 100 - - - - 8000 120 2.0 30 Examples 1-4 100 - - - - 5000 121 1.2 30 Examples 1-5 100 - - - - 5000 120 2.0 20 Examples 1-6 100 - - - - 5000 120 2.0 120 Examples 1-7 90 10 - - - 5000 120 2.0 30 Examples 1-8 90 - 10 - - 5000 120 2.0 30 Examples 1-9 90 - - 10 - 5000 120 2.0 30 Example 1-10 80 - 10 - 10 5000 120 2.0 30 Example 1-11 80 - 10 10 - 5000 120 2.0 30 Examples 1-12 80 - - 10 10 5000 120 2.0 30 Examples 1-13 80 10 - - 10 5000 120 2.0 30 Examples 1-14 70 - 10 10 10 5000 120 2.0 30 Examples 1-15 70 30 - - - 5000 120 2.0 30 Examples 1-16 70 - 30 - - 5000 120 2.0 30 Examples 1-17 70 - - 30 - 5000 120 2.0 30 Example 1-18 70 - - - 30 5000 120 2.0 30 Example 1-19 100 - - - - 5000 130 2.5 30

Example  1-20 to 1-22. White oyster Heat number  Distillate of extract

Example  1-20

Steam obtained by distilling the extract of Example 1-1 at 120-131 degreeC was condensed, and the distillate of the baekgulchae hot water extract was obtained.

Example  1-21

The vapor obtained by distilling the extract of Example 1-8 at 120-131 degreeC was condensed and the distillate of the baekgulchae hot water extract was obtained.

Example  1-22

The steam obtained by distilling the extract of Example 1-14 at 120-131 degreeC was condensed, and the distillate of baekgulchae hot water extract was obtained.

< Example  2. Manufactured under high temperature and high pressure conditions White oyster Heat number  Preparation of Wet Wipes Containing Extract or Distillate thereof>

340 g of the extract or distillate of Example 1 was spray-adsorbed onto a tissue cotton fabric 16 cm x 18 cm x 63 sheets (weight 100 g) (see Table 2). Next, the tissue treated with the extract or distillate was sealed-packed, and sterilized using a high-pressure retort sterilizer (Hi-RETORT STERILIZER, Daerin Machinery) to prepare a final wet tissue (15 at 121 ° C. under 1.2 atm). Sterilize for a minute).

wet tissue Extract condition Example 2-1 Using the extract of Example 1-1 Example 2-2 Using the extract of Example 1-2 Example 2-3 Using the extract of Example 1-3 Examples 2-4 Using the extract of Examples 1-4 Example 2-5 Using the extract of Example 1-5 Examples 2-6 Using the extract of Examples 1-6 Examples 2-7 Using the extract of Examples 1-7 Examples 2-8 Using the extract of Examples 1-8 Examples 2-9 Using the extract of Examples 1-9 Examples 2-10 Using the extract of Example 1-10 Examples 2-11 Using the extract of Examples 1-11 Examples 2-12 Using the extract of Examples 1-12 Examples 2-13 Using the extract of Examples 1-13 Examples 2-14 Using the extract of Examples 1-14 Examples 2-15 Using the extract of Examples 1-15 Examples 2-16 Using the extract of Examples 1-16 Examples 2-17 Using the extract of Examples 1-17 Examples 2-18 Using the extract of Examples 1-18 Example 2-19 Using the extract of Examples 1-19 Examples 2-20 Using the distillate of Example 1-20 Examples 2-21 Using the distillate of Example 1-21 Examples 2-22 Using the distillate of Example 1-22

< Example  3. White oyster Heat number  Preparation of Cotton Swabs and Gauzes Containing Extracts>

Purchasing cotton wool and cotton gauze fabric, spraying 240g Baekgulchae hot water extract of Example 1-1 per 100g weight of the cotton and cotton gauze fabric After drying, a cotton swab was prepared as a cotton swab, and the cotton gauze fabric was cut into an appropriate size to prepare a gauze for wound dressing. Thereafter, the swab and gauze were gamma-ray sterilized for 20 hours after the sealing packaging to prepare a final product.

< Example  4. White oyster Heat number  Preparation of Cotton Swabs and Gauzes Containing Distillates of Extracts>

Purchasing cotton wool and cotton gauze fabric, spraying 240g of distillate of Baekgulchae hot water extract of Example 1-20 per 100g of the cotton wool and cotton gauze fabric After drying, a cotton swab was prepared as a cotton swab, and the cotton gauze fabric was cut into an appropriate size to prepare a gauze for wound dressing. Thereafter, the swab and gauze were gamma-ray sterilized for 20 hours after the sealing packaging to prepare a final product.

< Comparative Example  1. Compared to White oyster Heat number  Preparation of Extracts>

To compare the Baekchulchae and water under the conditions of Table 3 to prepare a comparison of the hot water extract of Baekchulchae. On the other hand, in order to compare the effect of the extract of Baekgulchae, each extract of the sentence pattern, Prunus bark, Yangje-geun, Graft Alley mixed with Baekgulchae was prepared.

Condition Weight (g) Temperature
(° C) pressure
(atmospheric pressure) time
(minute) White oyster Moon style Sycamore tree Yang Jae-geun Grafting water Comparative Example 1-1 100 - - - - 5000 100 1.0 30 Comparative Example 1-2 100 - - - - 5000 90 1.0 30 Comparative Example 1-3 100 - - - - 5000 80 1.0 30 Comparative Example 1-4 90 10 - - - 5000 100 1.0 30 Comparative Example 1-5 90 - 10 - - 5000 100 1.0 30 Comparative Example 1-6 90 - - 10 - 5000 100 1.0 30 Comparative Example 1-7 80 - 10 - 10 5000 100 1.0 30 Comparative Example 1-8 80 - 10 10 - 5000 100 1.0 30 Comparative Example 1-9 80 - - 10 10 5000 100 1.0 30 Comparative Example 1-10 80 10 - - 10 5000 100 1.0 30 Comparative Example 1-11 70 - 10 10 10 5000 100 1.0 30 Comparative Example 1-12 70 30 - - - 5000 100 1.0 30 Comparative Example 1-13 70 - 30 - - 5000 100 1.0 30 Comparative Example 1-14 70 - - 30 - 5000 100 1.0 30 Comparative Example 1-15 70 - - - 30 5000 100 1.0 30 Comparative Example 1-16 - 100 - - - 5000 120 2.0 30 Comparative Example 1-17 - - 100 - - 5000 120 2.0 30 Comparative Example 1-18 - - - 100 - 5000 120 2.0 30 Comparative Example 1-19 - - - - 100 5000 120 2.0 30 Comparative Example 1-20 100 - - - - 5000 95 1.5 30

< Comparative Example  2. White oyster  Preparation of Wet Wipes Containing Organic Solvent Extraction>

To extract the white oysters using an aqueous 70% ethanol solution instead of water under the conditions of Table 4, after extraction, the filtrate was removed by removing the solids (medicine dry) to remove all the ethanol, respectively, by adding water The total weight of the extract was adjusted in the same manner as the extracts of Example 1-1.

Condition Weight (g) Temperature
(° C) pressure
(atmospheric pressure) time
(minute) White oyster Moon style Sycamore tree Yang Jae-geun Grafting 70% ethanol Comparative Example 2-1 100 - - - - 500 80 1.0 30 Comparative Example 2-2 80 20 - - - 500 80 1.0 30 Comparative Example 2-3 80 - 20 - - 500 80 1.0 30 Comparative Example 2-4 80 - - 20 - 500 80 1.0 30 Comparative Example 2-5 80 - - - 20 500 80 1.0 30

< Comparative Example  3. Preparation of Comparative Wipes>

To prepare a wet wipe in the same manner as in Example 2, the extract sprayed on the wet tissue was used under the conditions of Table 5.

wet tissue Extract condition Comparative Example 3-1 Using the extract of Comparative Example 1-1 Comparative Example 3-2 Using extract of Comparative Example 1-2 Comparative Example 3-3 Using the extract of Comparative Example 1-3 Comparative Example 3-4 Using the extract of Comparative Example 1-4 Comparative Example 3-5 Using the extract of Comparative Example 1-5 Comparative Example 3-6 Using the extract of Comparative Example 1-6 Comparative Example 3-7 Using the extract of Comparative Example 1-7 Comparative Example 3-8 Using the extract of Comparative Example 1-8 Comparative Example 3-9 Using the extract of Comparative Example 1-9 Comparative Example 3-10 Using the extract of Comparative Example 1-10 Comparative Example 3-11 Use of extract of Comparative Example 1-11 Comparative Examples 3-12 Use extract of Comparative Example 1-12 Comparative Example 3-13 Use extract of Comparative Example 1-13 Comparative Example 3-14 Using the extract of Comparative Example 1-14 Comparative Example 3-15 Using the extract of Comparative Example 1-15 Comparative Example 3-16 Using the extract of Comparative Example 1-16 Comparative Example 3-17 Use extract of Comparative Example 1-17 Comparative Example 3-18 Using the extract of Comparative Example 1-18 Comparative Example 3-19 Use extract of Comparative Example 1-19 Comparative Example 3-20 Using the extract of Comparative Example 1-20 Comparative Example 3-21 Using the extract of Comparative Example 2-1 Comparative Example 3-22 Use extract of Comparative Example 2-2 Comparative Example 3-23 Using extract of Comparative Example 2-3 Comparative Example 3-24 Using the extract of Comparative Example 2-4 Comparative Example 3-25 Using the extract of Comparative Example 2-5 Comparative Example 3-26 Add water only

< Comparative Example  4. Compared to White oyster Heat number  Preparation of Cotton Swabs and Gauzes Containing Extracts>

To prepare a cotton swab and gauze containing Baekchulchae hot-water extract in the same manner as in Example 3, a cotton swab and gauze was prepared by spraying the Baekchulchae hot-water extract of Comparative Example 1-1.

< Test Example  1. Long-term preservation confirmation>

The wet tissues of Example 2 and Comparative Example 3 were left at room temperature (25 ° C.) in a sealed package, but when one month was reached, the lids of the wet tissue packaging were opened and two sheets were taken out and used for the experiment. Thereafter, the lid of the wet tissue package was covered and left in the same sealed state as before, and when three months were taken out, two pieces were used again for the experiment. Then, when six months old, the last two were taken out and used for the experiment. At this time, care was taken when opening and closing the lid so that the wet tissue did not dry to the outside conditions, and stored in a closed space with a humidity of 80% or more.

And, using the wet tissue obtained at each time point, the growth degree of the general bacteria in the wet tissue was confirmed for each storage period. Each wet tissue was placed in a homogenous bag (stomacher bag) containing sterile peptone water, stirred for 120 seconds, and diluted in steps. Dilutions were plated with 0.1 ml each of plate count agar (PCA) plate media. Measurement of general bacteria was carried out using 3M Petri film after incubation for 24 hours at 35 ℃ in PCA medium. The experimental results are shown in Table 6 below.

wet tissue
Coliform count, log CFU / g 1 month 3 months 6 months Example 2-1 ND ND ND Example 2-2 ND ND ND Example 2-3 ND ND ND Examples 2-4 ND ND ND Example 2-5 ND ND ND Examples 2-6 ND ND ND Examples 2-7 ND ND ND Examples 2-8 ND ND ND Examples 2-9 ND ND ND Examples 2-10 ND ND ND Examples 2-11 ND ND ND Examples 2-12 ND ND ND Examples 2-13 ND ND ND Examples 2-14 ND ND ND Examples 2-15 ND ND ND Examples 2-16 ND ND ND Examples 2-17 ND ND ND Examples 2-18 ND ND ND Example 2-19 ND ND ND Examples 2-20 ND ND ND Examples 2-21 ND ND ND Examples 2-22 ND ND ND Comparative Example 3-1 ND 0.25 1.63 Comparative Example 3-2 ND 0.28 1.68 Comparative Example 3-3 ND 0.15 1.45 Comparative Example 3-4 ND 0.26 1.36 Comparative Example 3-5 ND 0.19 1.67 Comparative Example 3-6 ND 0.16 1.68 Comparative Example 3-7 ND 0.17 1.44 Comparative Example 3-8 ND 0.29 1.75 Comparative Example 3-9 ND 0.14 1.66 Comparative Example 3-10 ND 0.25 1.57 Comparative Example 3-11 ND 0.13 1.84 Comparative Examples 3-12 ND 0.16 1.45 Comparative Example 3-13 ND 0.17 1.76 Comparative Example 3-14 ND 0.20 1.92 Comparative Example 3-15 ND 0.38 1.63 Comparative Example 3-16 ND 0.57 1.91 Comparative Example 3-17 ND 0.68 1.80 Comparative Example 3-18 ND 0.59 1.90 Comparative Example 3-19 ND 0.56 1.87 Comparative Example 3-20 ND 0.16 1.78 Comparative Example 3-21 ND 0.15 1.55 Comparative Example 3-22 ND 0.29 1.60 Comparative Example 3-23 ND 0.33 1.64 Comparative Example 3-24 ND 0.36 1.83 Comparative Example 3-25 ND 0.42 1.46 Comparative Example 3-26 ND 1.62 3.42 Commercial wipes (Crineex, Yuhan-Kimberly) ND ND ND * ND: Not Detected

Referring to the results of Table 6, despite the sterilization treatment, the wet tissue of Comparative Example 3-26 added only water did not appear to inhibit the growth of common bacteria due to external contamination within a period of 6 months of manufacture, The remaining wet tissue of Comparative Example 3 was also confirmed that some of the general bacteria due to external contamination over time. However, the wet wipes of Example 2 of the present invention can be confirmed that the growth of the general bacteria is not at all for 6 months, so even if only the baekgulchae hot water extract of the present invention has the effect of suppressing external contamination without adding an antiseptic or antimicrobial agent. It was found that the preservation ability is excellent.

On the other hand, in the case of the wet tissues of Examples 2-1, Examples 2-20 to 2-22 up to 18 months at intervals of 3 months, the growth of the general bacteria in the wet tissue was carried out in the same manner, Example 2-1 The wet tissues of 0.3 log CFU / g or more bacteria was detected at 15 months (not detected until 12 months), but the wet tissues of Examples 2-20 to 2-22 were all 0.3 log CFU / g or more bacteria at 18 months Was detected (not detected until 15 months).

Therefore, it can be seen from the above results that the preservation property is higher than the wet tissue containing the distillate obtained by distilling the extract than the wet tissue containing Baekchulchae hot-water extract.

< Test Example  2. Checking the antimicrobial effect>

Antibacterial test for E. coli was performed on the wet tissue according to the present invention. Preparing a flask 250㎖ as the type of wipes, each phosphate buffer 70㎖ and E. coli (Escherichia coli , Accession No .: ATCC 25922) 5 ml of the inoculation solution was added thereto, and 0.75 g of the wet tissues of Example 2 and Comparative Example 3 were cut finely (not more than 1 × 1 cm) and each flask was added at 25 ± 5 ° C. Shaking (320 rpm) for 1 hour. Each shaken culture solution was diluted 10-fold with phosphate buffer solution, streaked by 0.1 ml in agarose medium, and each medium was incubated at 37 ° C. for 24 hours, and the results are shown in Table 7 only in water. The bacterial reduction rate was shown based on the wet tissue of Comparative Example 3-26 added.

wet tissue Bacterial reduction rate (%) Example 2-1 57.7 Example 2-2 65.5 Example 2-3 55.3 Examples 2-4 59.4 Example 2-5 56.5 Examples 2-6 57.6 Examples 2-7 76.3 Examples 2-8 78.4 Examples 2-9 81.2 Examples 2-10 76.3 Examples 2-11 80.5 Examples 2-12 82.3 Examples 2-13 77.4 Examples 2-14 81.6 Examples 2-15 81.5 Examples 2-16 79.7 Examples 2-17 78.5 Examples 2-18 79.4 Example 2-19 79.5 Examples 2-20 91.6 Examples 2-21 89.6 Examples 2-22 93.8 Comparative Example 3-1 37.9 Comparative Example 3-2 34.7 Comparative Example 3-3 39.8 Comparative Example 3-4 26.6 Comparative Example 3-5 27.7 Comparative Example 3-6 24.5 Comparative Example 3-7 35.6 Comparative Example 3-8 33.4 Comparative Example 3-9 24.5 Comparative Example 3-10 12.6 Comparative Example 3-11 33.7 Comparative Examples 3-12 37.5 Comparative Example 3-13 35.6 Comparative Example 3-14 26.7 Comparative Example 3-15 37.8 Comparative Example 3-16 9.5 Comparative Example 3-17 10.6 Comparative Example 3-18 11.7 Comparative Example 3-19 12.8 Comparative Example 3-20 26.5 Comparative Example 3-21 37.6 Comparative Example 3-22 18.7 Comparative Example 3-23 39.4 Comparative Example 3-24 26.5 Comparative Example 3-25 17.6 Comparative Example 3-26 0.0 Commercial wipes (Crineex, Yuhan-Kimberly) 56.8

As a result, the medium added with the wet tissue product according to the present invention showed a significant bacterial reduction rate compared to the wet tissue of Comparative Example 3-26, which was confirmed to be superior to the antibacterial properties of commercial wet tissue products. On the other hand, in the case of wet tissues (Comparative Examples 3-16 to Comparative Example 3-19) prepared with a herbal extract that does not contain at all, the antibacterial effect is almost, the antibacterial effect of the wet tissue of the present invention is essential composition It can be seen that it appears only as an element.

< Test Example  3. Check the anti-inflammatory effect>

In order to confirm the anti-inflammatory effect of the wet tissue of the present invention, a group of 10 patients with bacterial conjunctivitis was wiped by wiping both eyelids once every 6 hours using the wet wipes of Example 2 and Comparative Example 3. In addition, for accurate comparison experiments, 0.1 drops of flumethorone (main ingredient: fluorometholone), a therapeutic agent for bacterial conjunctivitis, were applied dropwise every 6 hours, and the therapeutic effect after 2 days of use was described in Table 5 below. .

Condition Treatment effect after 2 days of use Wipes of Example 2-1 3.0 Wipes of Example 2-2 3.2 Wipes of Examples 2-4 3.1 Wipes of Examples 2-11 4.0 Wipes of Examples 2-12 3.9 Wipes of Example 2-13 3.9 Wipes of Examples 2-20 4.4 Wipes in Comparative Example 3-1 2.0 Wipes in Comparative Example 3-3 1.8 Wipes of Comparative Examples 3-8 2.0 Wipes in Comparative Example 3-10 1.9 Wet tissue of Comparative Example 3-20 2.0 Wipes in Comparative Example 3-21 1.9 Comparative Example 3-26 wipes 1.1 Flumetone 0.1 eye drops 4.8 5: improvement of over 90%, 4: improvement of over 70%,
3: improvement over 50%, 2: improvement over 30%, 1: no effect

Checking the results of Table 8, when using the wet tissue of Example 2, it was found that the therapeutic effect is similar to that of using a flumetorone 0.1 eye drops. In addition, the main symptom relief effects were confirmed to include decongestion, inflammation reduction, dry eye suppression, and pain suppression.

< Test Example  4. Confirmation of atopy improvement effect>

In order to confirm the atopy improvement effect of the wet wipes of the present invention, 10 out of 20 to 50 year old men and women who were diagnosed with atopy in both hospitals in 2012 as a group, and confirmed the atopy improvement effect. For each group of atopic patients, wipe the area where itching occurs due to atopy for 2 weeks by using wet wipes four times a day for 5 to 6 hours before using the moisturizer, and improve the atopic effect of symptoms caused by itching and eczema. In Table 9 is shown by the five-point RBI method.

Condition Atopy improvement effect Wipes of Example 2-1 3.0 Wipes of Example 2-2 3.1 Wipes of Examples 2-4 3.2 Wipes of Examples 2-11 3.8 Wipes of Examples 2-12 3.9 Wipes of Examples 2-20 4.3 Wipes in Comparative Example 3-1 2.0 Wipes in Comparative Example 3-3 1.9 Wipes of Comparative Examples 3-8 1.8 Wet tissue of Comparative Example 3-20 1.7 Wet tissue of Comparative Example 3-20 1.8 Comparative Example 3-26 wipes 1.1 Commercial wipes (Crineex, Yuhan-Kimberly) 1.2 5: improvement of over 90%, 4: improvement of over 70%,
3: improvement over 50%, 2: improvement over 30%, 1: no effect

Referring to Table 9, it can be seen that the wet tissue of the present invention is very excellent in atopic improvement.

< Test Example  5. Check the effect of wound improvement>

In order to confirm the wound healing effect of the wet wipes of the present invention, wounds of 10 people having a wound of 2 to 5 cm in length and within a depth of 3 mm were treated as a group, and the wound area was sterilized and the gauze of Examples 3 and 4 were compared. The wound site was dressed using 4 gauze. Normal sterile gauze was used for the comparison. After 24 hours, the gauze was replaced, and after 24 hours, the degree of improvement of the wound was confirmed by a 5-point RBI method in Table 10.

Condition Wound healing and improvement after 2 days of use Gauze of Example 3 3.2 Gauze of Example 4 4.2 Gauze of Comparative Example 4 2.2 General commercial gauze 1.1 5: very good, 4: good, 3: medium, 2: bad, 1: very bad

Checking the results of Table 10, it can be seen that the effect of the gauze of Examples 3 and 4 to improve the wound is significantly superior to the case of using the gauze of the comparative example 4 or the general gauze. In particular, the wound healing improvement effect of Example 4 gauze including distillate of Baekchulchae hot water extract was remarkably superior to the wound healing improvement effect of Example 3 gauze including Baekchulchae hot water extract.

In addition, when using the gauze of Examples 3 and 4 when the wound site was confirmed, the wound was well healed, but almost no scab was formed, and the therapeutic effect was shown to be good, but the general gauze was generated badly. In addition, there was little effect to improve the wound area.

< Test Example  6. Closed cloth inspection  Used White oyster  Check the skin irritation level of the extract>

A closed patch test was performed to confirm skin irritation of the baekryechae hot-water extract or distillate used in the wet tissue of the present invention (human closed patch test). This test method is widely used as a method to search for primary irritants. To this end, 40 μl of the extract or distillate of Table 11 was added to the back of each 30 healthy males and females using a kit (Finn chamber), and fixed to the skin with a tape (scanpore tape). After 24 hours it was removed from the skin and after 4 hours the results were determined. The degree of erythema and edema is indicated by the numbers shown below. The criteria for acceptance were in accordance with the criteria of the International Contact Dermatitis Research Group (ICDRG) (Wooding et al, 1967; Rietschell, 1982; Fischer & Maibach, 1984; Aberer et al, 1993).

[Criteria]

0 = no redness

1 = mild erythema

2 = intense erythema

3 = intense erythema with edema

4 = intense erythema with edema and vesicle

Extract or distillate Stimulus degree of closed patch test (0 ~ 4 standard) Example 1-1 0.02 Examples 1-4 0.04 Example 1-10 0.07 Example 1-11 0.04 Examples 1-12 0.02 Examples 1-13 0.05 Example 1-20 0.03 Comparative Example 1-1 0.36 Comparative Example 1-9 0.37 Comparative Example 1-10 0.48 Comparative Example 1-11 0.43 Comparative Example 1-12 0.36 Comparative Example 1-20 0.32 Comparative Example 2-1 0.38 Comparative Example 2-2 0.65 Comparative Example 2-3 0.42 Comparative Example 2-4 0.45 Comparative Example 2-5 0.41

Checking the Table 11, in the case of the extract or distillate of Example 1 appeared to have almost no skin irritation was found to have excellent skin stability effect by the composition of the present invention.

However, in the extracts of Comparative Examples 1 and 2, the irritation degree of the closed patch test was greater than that of the extract of Example 1, indicating that the skin stability was relatively lowered.

Therefore, due to the above results, it was expected that the skin irritation when using the wet tissues containing the extract of Example 1 or the distillate was less than that when using the wet tissues containing the extracts of Comparative Examples 1 and 2.

Claims (12)

A wet tissue characterized in that it contains hot water extract of Baekgulchae hot water extracted at 120-131 ° C. and 1.2-2.8 atm of high temperature and high pressure by mixing 2000-8000 parts by weight of water with 100 parts of Baekgulchae. delete The method of claim 1,
The Baekgulchae hot-water extract, based on 100 parts by weight of Baekchulchae, moist tissue, characterized in that the production of one or more herbal medicines selected from the group consisting of Moon-shaped, Prunus bark, Yangje-geun and Graft Alley added to 1 to 50 parts by weight. The method of claim 1,
The wet tissue containing the Baekchulchae hot-water extract is sprayed 200-400 parts by weight of the Baekchulchae hot-water extract on 100 parts by weight of the fabric for wet tissue to absorb the Baekhwachae hot-water extract on the fabric for wet wipes, Wet tissue, characterized in that the wet tissue is prepared by sealing the packaging and sterilization fabric. 5. The method of claim 4,
The wet tissue fabric is a wet tissue, characterized in that selected from the group consisting of natural pulp, cotton, ingio, tencel, natural fiber fabrics, blended fiber fabrics, non-woven fabric and synthetic fiber fabrics. Toilet paper, cotton swabs, gauze, masks, diapers and mixed with 2000 ~ 8000 parts by weight of water to 100 parts by weight of baekgulchae containing Baekgulchae hot water extract extracted under high temperature and high pressure conditions of 120 ~ 131 ℃ and 1.2 ~ 2.8 Products selected from sanitary napkins. (Step 1) mixing 2000-8000 parts by weight of water with 100 parts by weight of baekgulchae and extracting at 120-131 ° C. and 1.2-2.8 atm under high temperature and high pressure conditions to produce baekgulchae hot-water extract;
(Step 2) by spraying 200 ~ 400 parts by weight of baekchulchae hot-water extract prepared in step 1 to 100 parts by weight of the tissue for wet tissue to absorb the baekchulchae hot-water extract on the tissue for wet tissues; And
(3 step) sealing and wrapping the fabric for wet tissue absorbed by the baekchulchae hot-water extract to sterilize to prepare a wet tissue containing baekchulchae hot-water extract;
Wet tissue manufacturing method comprising a. (Step A) mixing 2000-8000 parts by weight of water with 100 parts by weight of baekchulchae and extracting at 120-131 ° C. and 1.2-2.8 atm of high temperature and high pressure conditions to produce baekchulchae hot-water extract;
(Step B) 100 parts by weight selected from toilet paper fabric, cotton wool, gauze fabric, cotton fabric, natural fiber fabric, synthetic fiber fabric, blended fiber fabric and nonwoven fabric, Baekgulchae hot-water extract prepared in step A Spraying 10 to 400 parts by weight to absorb baekchulchae hot-water extract;
(C step) drying one selected from toilet paper fabric, cotton wool, gauze fabric, cotton fabric, natural fiber fabric, synthetic fiber fabric, blended fiber fabric and nonwoven fabric absorbed by the baekchulchae hot water extract; And
(D process) toilet paper, cotton swab, gauze, using one kind selected from the dried toilet paper fabric, cotton wool, gauze fabric, cotton fabric, natural fiber fabric, synthetic fiber fabric, blended fiber fabric and non-woven fabric of the process C Preparing, packaging and sterilizing a product selected from a mask, a diaper and a sanitary napkin;
Toilet paper, swab, gauze, mask, diaper and sanitary napkin comprising the manufacturing method of the product. Containing distillate of baekgulchae hot-water extract condensed steam obtained by distilling the baekgulchae hot-water extract extracted under the high temperature and high pressure conditions of 120-131 ℃ and 1.2-2.8 atm by mixing 2000-8000 parts by weight of water Wet wipes characterized in that. Containing distillate of baekgulchae hot-water extract condensed steam obtained by distilling the baekgulchae hot-water extract extracted under the high temperature and high pressure conditions of 120-131 ℃ and 1.2-2.8 atm by mixing 2000-8000 parts by weight of water Products selected from toilet paper, cotton swabs, gauze, masks, diapers and sanitary napkins. (Step 1) mixed with 2000 ~ 8000 parts by weight of water to 100 parts by weight of baekgulchae, extract under high temperature and high pressure conditions of 120 ~ 131 ℃ and 1.2 ~ 2.8 atm to prepare a baekgulchae hot water extract, and distilled the baekgulchae hot water extract Condensing the obtained steam to prepare a distillate of Baekchulchae hot-water extract;
(Step 2) by spraying 200 ~ 400 parts by weight of the distillate of Baekgulchae hot-water extract prepared in step 1 to 100 parts by weight of the cloth for wet tissues to absorb the distillate of Baekgulchae hot-water extract on the fabric for wet tissues; And
(3 step) to seal and wrap the fabric for wet tissues in which the distillate of the baekchulchae hot-water extract is absorbed and sterilized to prepare a wet tissue containing distillate of the baekchulchae hot-water extract;
Wet tissue manufacturing method comprising a. (Step A) 100 parts by weight of baekgulchae mixed 2000-8000 parts by weight of water and extracted under high temperature and high pressure conditions of 120 ~ 131 ℃ and 1.2 ~ 2.8 atm to prepare a baekgulchae hot-water extract, and distilled the baekgulchae hot-water extract Condensing the obtained steam to prepare a distillate of Baekchulchae hot-water extract;
(Step B) 100 parts by weight selected from toilet paper fabric, cotton wool, gauze fabric, cotton fabric, natural fiber fabric, synthetic fiber fabric, blended fiber fabric and nonwoven fabric, Baekgulchae hot-water extract prepared in step A Spraying 10 to 400 parts by weight of a distillate of absorbing the distillate of Baekchulchae hot-water extract;
(C process) drying one kind selected from toilet paper fabric, cotton wool, gauze fabric, cotton fabric, natural fiber fabric, synthetic fiber fabric, blend fiber fabric and nonwoven fabric absorbed by the distillate of Baekchulchae hot-water extract ; And
(D process) toilet paper, cotton swab, gauze, using one kind selected from the dried toilet paper fabric, cotton wool, gauze fabric, cotton fabric, natural fiber fabric, synthetic fiber fabric, blended fiber fabric and non-woven fabric of the process C Preparing, packaging and sterilizing a product selected from a mask, a diaper and a sanitary napkin;
Toilet paper, swab, gauze, mask, diaper and sanitary napkin comprising the manufacturing method of the product.

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