KR101317368B1 - Composition for treatment of premature ejaculation - Google Patents

Abstract

The present invention relates to a composition for delaying the ejaculation of a male including Hamo, Bokbunja, Sukjihwang, lotus root, cornus, persimmon, shiho, softening example and raw meat as active ingredients. The composition of the present invention is effective in the prevention, treatment and improvement of premature ejaculation.

Description

Chinese medicine composition for treating premature ejaculation {COMPOSITION FOR TREATMENT OF PREMATURE EJACULATION}

The present invention relates to a composition for preventing, improving and treating premature ejaculation.

In general, premature ejaculation refers to a case in which the ejaculation is continuously or repeated immediately before or immediately after insertion or the delay time to ejaculation is extremely short despite sexual stimulation. Premature ejaculation is the most common sexual dysfunction in men, and as many as three out of four men will experience it at least once in their lifetime. In addition, as a result of surveying 2,000 adult males at the Korean Academy of Male Scientists, 27.5% of Korean adult males think that they have premature ejaculation symptoms.

However, premature ejaculation is not known yet, and there is no clear and effective treatment. For this reason, there have been attempts to delay the ejaculation time by using an auxiliary mechanism such as a premature ejaculation condom (registered patent publication No. 10-0559748).

The inventors of the present invention, while studying the drugs to delay the ejaculation time of men, that hot water extracts including Hamo, Bokbunja, Sukjihwang, lotus root, cornus, persimmon, shiho, softening example and raw meat are effective in delaying and controlling ejaculation It confirmed and completed this invention.

It is an object of the present invention to provide a composition for preventing, improving and treating premature ejaculation.

Another object of the present invention is to provide a composition for delaying ejaculation in men.

Another object of the present invention is to provide a method for preparing the compositions.

In order to achieve the above object, the present invention provides a composition for the prevention, improvement and treatment of premature ejaculation, including Hamochi, Bokbunja, Sukjihwang, lotus root, cornus, persimmon, shiho, softening example and raw meat as an active ingredient.

In another aspect, the present invention provides a composition for delaying the ejaculation of men, including Hamoru, Bokbunja, Sukjihwang, lotus root, cornus, persimmon, shiho, softening example and raw meat as an active ingredient.

In another aspect, the present invention provides a method for producing the composition comprising the step of extracting the hot water, bokbunja, sukjihwang, lotus root, cornus, persimmon, shiho, softening example and raw meat.

The composition of the present invention is effective in preventing, ameliorating and treating premature ejaculation. More specifically, the composition of the present invention is effective in delaying the time required for male ejaculation after insertion (intravaginal ejaculatory latency time).

1 shows the IELT change in a patient when administering a sample of the present invention.

The present invention relates to a composition for the prevention, improvement and treatment of premature ejaculation comprising Hamo, Bokbunja, Sukjihwang, lotus root, cornus, persimmon, shiho, softening example and raw meat as active ingredients.

In addition, the present invention relates to a composition for delaying the ejaculation of men, including Hamo, Bokbunja, Sukjihwang, lotus root, cornus, persimmon, shiho, softening example and raw meat as active ingredients.

In another aspect, the present invention relates to a method for producing the composition comprising the step of extracting the hot water, Bokbunja, Sukjihwang, lotus root, cornus, persimmon, shiho, softening example and raw meat.

Hereinafter, the present invention will be described in detail.

The composition of the present invention, Hamochi, Bokbunja, Sukjihwang, lotus root, cornus, persimmon, shiho, softening example and raw meat as an active ingredient.

In addition, the composition of the present invention may further comprise a vaccine or a lower bone.

In addition, the composition of the present invention may further include one or more selected from the group consisting of licorice, hair, yellow white, golden and new songs.

The lower ribs and lower keels are powdered or carburized keels after hot treatment, respectively. Hamochi and hagol is a medicine widely used in the art, the manufacturing method is generally carried out in the art, the detailed description thereof will be omitted.

The composition of the present invention is based on 100 parts by weight of hamori, bokbunja 150-200 parts by weight, 50-150 parts by weight of sucrose sulfur, 100-200 parts by weight soft corn, 50-100 parts by weight of cornus oil, 50-100 parts by weight, persimmon 50 It may include ~ 100 parts by weight, softening example 50 ~ 100 parts by weight and raw meat 50 ~ 150 parts by weight.

In addition, the composition of the present invention may contain from 25 to 75 parts by weight of each of the vaccine or the lower keel with respect to 100 parts by weight of the hamor.

In addition, the composition of the present invention may contain 10 to 40 parts by weight of licorice, gimo, yellowish white, golden or new song, respectively, based on 100 parts by weight of hamori.

The present invention is to prepare a pharmaceutical composition for delaying the ejaculation, improvement and treatment of premature ejaculation, including the step of extracting the hot water, bokbunja, Sukjihwang, lotus root, cornus, persimmon, shiho, softening example and raw meat Provide a method.

In another aspect, the present invention provides a method for producing a composition for delaying the ejaculation of a pharmaceutical composition / male for preventing, improving and treating premature ejaculation comprising the step of extracting hot water of the medicine of the present invention.

The present invention is a pharmaceutical composition for preventing, improving and treating premature ejaculation comprising the steps of extracting hot water from bokbunja, sukji sulfur, lotus root, cornus, persimmon, shiho, softening example, raw meat, baekboksin and lower bones. It provides a method for producing.

In another aspect, the present invention is to prevent, improve the premature ejaculation comprising the step of extracting the hot water, bokbunja, Sukjihwang, lotus root, cornus, persimmon, shiho, softening example, raw meat, baekboksin, hayonggol, licorice, jimo, yellow white, golden and new song And a method for preparing the therapeutic pharmaceutical composition / composition that delays ejaculation of the male.

The composition of the present invention may be a pharmaceutical composition or a food composition.

The composition of the present invention may be a pharmaceutical composition for the prevention and treatment of premature ejaculation.

The pharmaceutical composition of the present invention may include 0.01 to 99 parts by weight of the medicinal extract, based on 100 parts by weight of the composition, preferably 0.02 to 80 parts by weight. However, it can be increased or decreased according to the needs of the dosers, and can be appropriately increased or decreased depending on the diet, nutritional status, and degree of premature ejaculation.

The pharmaceutical compositions of the present invention can be administered orally or parenterally, can be applied and used, and can be used in the form of general pharmaceutical preparations. The preferred pharmaceutical preparations are those for oral administration such as tablets, hard or soft capsules, liquids, suspensions, etc. These pharmaceutical preparations can be prepared in conventional pharmaceutically acceptable carriers, for example, as excipients for oral preparations, Binders, disintegrators, lubricants, solubilizers, suspending agents, preservatives or extenders.

The dosage of the pharmaceutical composition of the present invention can be determined by a specialist according to various factors such as the patient's condition, age, weight, and the severity of premature ejaculation, but generally from 0.1 mg to 10 g, preferably 1 mg to 1 kg of adult. It may be administered at a dose of 5 g. Also, the daily dosage of the pharmaceutical composition per unit dosage form, or a half, 1/3 or 1/4 dose thereof, may be contained, and may be administered 1 to 6 times per day. However, in the case of long-term intake, the amount may be below the above range, and the active ingredient may be used in an amount above the above range because there is no problem in terms of safety.

In addition, the composition of the present invention may be a food composition. The food is not limited to, but not limited to, health supplements, health functional foods, functional foods, and the like, including the addition of the medicinal herb extract of the present invention to natural foods, processed foods, and general food materials.

The food composition including the medicinal extract of the present invention may be added as it is, or used with other food or food compositions, and may be appropriately used according to conventional methods. The amount of the active ingredient to be mixed can be suitably determined according to its intended use (prevention, improvement, or therapeutic treatment). In general, the medicinal extract of the present invention may be added 0.1 to 90 parts by weight, preferably 1 to 60 parts by weight based on 100 parts by weight of the raw material of the food or beverage in the manufacture of food or beverage. The effective dose of the medicinal extract can be used in accordance with the effective dose of the pharmaceutical composition, but in the case of long-term intake for improving sexual life, it may be less than the above range, since the active ingredient has no problem in terms of safety in the above range The above amounts may also be used.

There is no particular limitation on the kind of the food. The food composition comprising the medicinal extract may be used in the form of oral preparations, such as tablets, hard or soft capsules, solutions, suspensions, etc., these preparations are acceptable conventional carriers, for example oral preparations In the case of excipients, binders, disintegrants, lubricants, solubilizers, suspending agents, preservatives or extenders can be prepared.

Hereinafter, the present invention will be described in more detail with reference to the following examples and experimental examples. However, the following examples and experimental examples are intended to illustrate the contents of the present invention, but the scope of the invention is not limited by the examples and the experimental examples.

≪ Materials and methods >

material

Hamo-ri, Bokbunja, Sukji-hwang, lotus root, cornus, persimmon, shiho, Yeonhwa-ye, raw meat, baekboksin, Haegol, licorice, jimo, baekbaek, gold and new songs were purchased from domestic medicinal herbs. Water was added to these medicines four times the weight of the medicine to extract for 2-4 hours to prepare a hydrothermal extract was used as a sample of the present invention.

6 weeks old male and female SD mice (female: 170g, male: 225g) were used as test animals, and were used for testing after adapting under conditions of a temperature of 232 ° C, 5510% RH, and a 12 hour lighting cycle for one week after purchase. Males with short incubation period were selected through pre-screening, and females were inoculated with ovaries and subcutaneous injection of estradiol valerate to induce heat.

Statistical processing

All experimental results were expressed as mean standard deviation (SD), and statistical significance between groups was analyzed by ANOVA using Statistical Package for Social Science (SPSS) version 12.0.1. Duncan's multiple range test was used to test for significant differences between groups, at p <0.05 level

<Examples>

Hamori, Bokbunja, Sukjihwang, lotus root, cornus, persimmon, shiho, softening example, raw meat, Baekboksin and Haeggol were mixed in the composition of Table 1 below. Four times the weight of the medicine was added to the hot water extract for 4 hours to prepare a hot water extract. The residue of the hot water extract was removed and concentrated under reduced pressure.

<Experimental Example 1>

The reduced pressure concentrated samples of Examples 1 to 7 and Comparative Examples 1 to 12 were administered to distilled water three times a day for 2 weeks in male mice. The mating estrus-derived females and males were placed in cages and observed mating process according to Male rat sexual behavior (A Agmo in Brain research Brain research protocols (1997)). Seven mice were used in each group.

Incidence of mounting without in tromission, incidence of pelvic thrust without vaginal penetration

Incidence of mounting with intromission

Mounting latency

Insertion latency

Ejaculation latency

Postejaculatory interval

As a result, it was confirmed that the ejaculation latencies of the Examples 1 to 6 administration groups were significantly increased (Table 2).

Experimental Example 2 Clinical Trial

Hamori 100 parts by weight, bokbunja 180 parts by weight, sucrose sulfur 100 parts by weight, softened meat 150 parts by weight, corn oil 75 parts by weight, persimmon 75 parts by weight, sea hoe 75 parts by weight, softening example 75 parts by weight, raw meat 100 parts by weight, bagboksin 50 weights Boil, 50 parts by weight of bone, licorice 25 parts by weight, 25 parts by weight of jimo, 25 parts by weight of yellow white, 25 parts by weight of gold and 25 parts by weight of new song, and boil it for 13 hours with 10 times the weight of water compared to the sample. Was prepared. The hot water extract was filtered to remove the residue to prepare a sample.

In spite of sexual stimulation, ejaculation was carried out immediately or immediately before or immediately after insertion, or 20 men in their 20s and 40s who had delayed time to ejaculation within 2 minutes were given 120 ml of the sample three times a day for 50 days. IELT (intravaginal ejaculatory latency time) was measured before and after administration.

As a result, there was a difference in the degree of increase of the IELT, it was confirmed that the IELT all increased by the administration of the sample (Fig. 1). At this time, subject 10, subject 19 and subject 20 were assessed before or immediately after insertion, and IELT before sample administration was zero.

Claims (10)

Hamochi, Bokbunja, Sukjihwang, lotus root, cornus, persimmon, shiho, softening and raw meat as an active ingredient, a pharmaceutical composition for preventing and treating premature ejaculation.
The method of claim 1,
Bokbunja 150-200 parts by weight, 50-150 parts by weight of sucrose sulfur, 100-200 parts by weight of soft broth, 50-100 parts by weight of cornus oil, 50-100 parts by weight, persimmon 50-100 parts by weight , Softening Example 50-100 parts by weight and raw meat 50-150 parts by weight.
The method of claim 1,
Pharmaceutical composition, characterized in that it further comprises a vaccine or lower bone.
The method of claim 3, wherein
The pharmaceutical composition, characterized in that it comprises 25 to 75 parts by weight of the vaccine or the lower bone bone with respect to 100 parts by weight of the hakimyeo.
The method of claim 1,
Pharmaceutical composition, characterized in that it further comprises one or more selected from the group consisting of licorice, gimo, yellow white, golden and new song.
6. The method of claim 5,
The licorice, gimo, yellowish white, golden or new song based on 100 parts by weight of the hakimyeo pharmaceutical composition, characterized in that it comprises 10 to 40 parts by weight.
The method of claim 1,
A pharmaceutical composition, characterized by delaying ejaculation in men.
A food composition for delaying the ejaculation of men comprising Hamo, Bokbunja, Sukjihwang, lotus root, cornus, persimmon, shiho, softening example and raw meat as active ingredients.
The method of claim 8,
Food composition, characterized in that it further comprises baekxin or lower keel. delete

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