KR101263939B1 - Fluorescent indication clip for surgery - Google Patents

Abstract

The photoreactive fluorescent substance is mounted on the biological clip to enhance the function as a position indicator, so that it is easy and quick to find the exact position of the target body in the body, thereby improving the accuracy of the procedure and minimizing the side effects after the procedure due to excessive incision. Disclosed is a fluorescent display clip. The surgical fluorescent display clip of the present invention includes a clip main body having self-expansion, a fluorescent display unit provided at a rear end of the clip main body and containing a photoreactive fluorescent substance, and an external force from a position mounted on the fluorescent display unit. By sliding to the clip main body by may include a tightening portion for tightening to close the tip of the clip main body.

Description

Surgical Fluorescent Marking Clips {FLUORESCENT INDICATION CLIP FOR SURGERY}

The present invention relates to a fluorescent display clip for surgery, and more particularly, a fluorescent display for mounting the photoreactive fluorescent substance on the biological clip to enhance the function as a position indicator to quickly and easily find the exact position of the target site in the body procedure It's about the clip.

Conventionally, a surgical method generally used in surgical procedures for treatment of colorectal cancer, gastric cancer, etc. is performed by endoscopically injecting the body into the body, and visually confirming the treatment site, such as a cancer occurrence site, and then opening the body or performing laparoscopic surgery. The incision is removed by incision.

However, in the conventional method, since the viewing angle and range obtained through the endoscope and the viewing angle and range obtained through the laparoscopic or laparoscope are completely different, it is difficult to accurately find the target position to be incision outside the body. Therefore, there is a problem in that the accuracy and range of the incision inevitably vary depending on the operator's sense and skill.

On the other hand, as a way to solve this problem, the Korean Patent Publication No. 2005-0110013 "clip and clip of biological tissue" developed for the purpose of hemostasis during endoscopy and "CLIP DEVICE FOR ENDOSCOPE AND CLIP" of US Patent US07357805 FOR ENDOSCOPE FOR USE THEREIN ", etc., a living body clip is disclosed. The disclosed biological clip is mounted on a separately manufactured clip manipulation device and transferred to a target position in the body, thereby clipping the living tissue to perform marking for displaying the position when cutting the tissue.

However, the operator cannot see the biological clip directly with the naked eye while the biological clip is clipped to the surgical site in the body, and in recent years, laparoscopic surgery or the like cannot directly touch the biological clip. Can't easily find its exact location. Therefore, there is a problem that the accuracy of the procedure is lowered and the risk of surgical side effects due to excessive incision is great.

Patent Document 1: Publication No. 10-2005-0110013 Patent Document 2: Japanese Patent Publication No. 3568280

The present invention has been made in order to solve the above problems, by mounting a photoreactive fluorescent substance in the biological clip to enhance the function as a position indicator to quickly and easily find the exact position of the treatment target site in the body accuracy of the procedure The purpose of the present invention is to provide a surgical fluorescent display clip that can increase the side effects and minimize the side effects due to excessive incision.

The objects of the present invention are not limited to the above-mentioned objects, and other objects not mentioned can be clearly understood by those skilled in the art from the following description.

Surgical fluorescent display clip according to a preferred embodiment of the present invention for achieving the above object, the clip body having a self-expansion (, 性), the fluorescence provided at the rear end of the clip body and containing a photoreactive fluorescent material It may include a display unit, and a fastening unit for tightening to close the tip of the clip main body while being slid to the clip main body by an external force from the position mounted on the fluorescent display.

In addition, the clip main body may include a proximal end to which the fluorescent display unit is coupled, a bilateral arm extending forward from the proximal end, and a clamping unit configured to bend the distal end of the both arm inwards and to hold the biological tissue.

In addition, the arms are formed stepped so as to have a plate width that is smaller than the plate width of the latching portion, the latching portion on which the operation arm of the clip operating device is latched, and the fastening portion is caught to maintain the grip state of the clip. And a concave portion formed between the step portion and the step portion and the proximal end to have self-expansion.

In addition, the latch portion is preferably formed to be tapered from the front end to the rear end.

In addition, the clip body may be made of a polymer material in which a photoreactive fluorescent substance is mixed, or a photoreactive fluorescent substance is coated on the surface of the clip body so that the clip itself may be fluorescent.

In addition, the fluorescent display part may be detachably coupled to the clip body or may be integrally formed with the clip body.

The fluorescent display may include a case in which the photoreactive fluorescent substance is embedded, and a fastening part provided in the case to fasten the case to the clip body.

In addition, the case is preferably made of a transparent material and a light transmissive material.

In addition, the fastening portion extends forward from both sides of the front end of the case, and fastening protrusions are formed inward at each of the extended ends, and the rear end of the clip body may be inserted into the fastening protrusions and fastened.

In addition, the tightening unit may include a tightening ring having a cylindrical shape so as to slide in the outer diameter of the fluorescent display.

In addition, the surgical fluorescent display clip of the present invention, the clip body, integrally formed or detachably coupled to the rear end of the clip body, a fluorescent display portion including a photoreactive fluorescent material, and the external force from the mounting position of the fluorescent display portion It may include a fastening ring for tightening the clip body so that the clip body can clip the biological tissue while being slid to the clip body by.

Specific details of other embodiments are included in the detailed description and the drawings.

According to the surgical fluorescent display clip of the present invention as described above, by adding a photoreactive fluorescent substance to the existing biological clip to enhance the function as a position indicator, it is possible to quickly and easily find the exact position of the site to be cut during the procedure This can improve the accuracy of the procedure and minimize the side effects due to excessive incisions.

In addition, it is possible to use the existing endoscope device as it is to carry out the in vivo clip transport and fastening operation, it is possible to use without the need to introduce additional additional imaging equipment during the procedure.

In addition, since the use of a light source such as a laser, LED, etc. harmless to the human body for the location of the fluorescent material added to the clip body, there is almost no effect on the patient during the procedure, so a safe procedure is possible.

In addition, the light source device can be manufactured in a thin and long form that can pass through the trocar using optical fibers, so that it can be used not only for conventional open surgery but also for laparoscopic surgery, and for various surgical procedures in addition to gastric and colorectal cancer procedures. It is a very wide field of application as a placeholder that can easily and quickly find a surgical target area.

In addition, in order to more effectively detect the light emitted from the photoreactive fluorescent material, the optical filter in the form of a flat plate is mounted at the tip of the optical fiber, or the operator wears an optical filter device in the form of glasses, or on the light passage path inside the endoscope device. It is possible to incorporate a light filter. Therefore, it is possible to provide a new surgical method for performing an incision procedure while visually confirming the position of the clip through the endoscope screen.

The effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned can be clearly understood by those skilled in the art from the description of the claims.

1 and 2 are perspective views of a surgical fluorescent display clip according to a preferred embodiment of the present invention.
3 is a perspective view illustrating a fluorescent display clip having an integrated structure of a clip body and a fluorescent display unit.
4 is a perspective view of the clip body.
5 is a side view of the clip body.
6 and 7 are exemplary views illustrating an example in which a fluorescent material is included in the clip body itself.
8 is a perspective view of the fluorescent display unit.
9 and 10 are cross-sectional views showing usage forms of the fluorescent display clip of the present invention.

Advantages and features of the present invention, and a configuration and method for achieving them will be apparent with reference to the embodiments described below in detail with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but can be implemented in various different forms, only the embodiments are to make the disclosure of the present invention complete, and the general knowledge in the technical field to which the present invention belongs It is provided to fully convey the scope of the invention to those skilled in the art, and the present invention is defined only by the scope of the claims. For reference, the same components according to various embodiments of the present disclosure will be described with reference to the same reference numerals. In addition, in describing the present invention, when it is determined that a detailed description of a related known function or configuration may unnecessarily obscure the subject matter of the present invention, the detailed description thereof will be omitted.

Prior to the description, the terminus side of the terms used in the present embodiment refers to the side of the living tissue in use state, and the terminus side refers to the side opposite to the living tissue.

Hereinafter, a fluorescent display clip for surgery according to a preferred embodiment of the present invention with reference to the accompanying drawings will be described in detail.

1 and 2 are a perspective view of a surgical fluorescent display clip according to an embodiment of the present invention, Figure 1 is a view showing an expanded state of the clip, Figure 2 is a view showing a closed state of the clip. 3 is a perspective view illustrating a fluorescent display clip having an integrated structure of a clip body and a fluorescent display unit, FIGS. 4 and 5 are perspective views and side views of the clip body, and FIGS. 6 and 7 are fluorescent materials on the clip body itself. FIG. 8 is an exemplary view illustrating an example in which the light emitting device is included. FIG. 8 is a perspective view of the fluorescent display unit.

As shown in Figures 1 to 8, the surgical fluorescent display clip 100 according to a preferred embodiment of the present invention may include a clip body 110, a fluorescent display unit 120 and a fastening unit 130 and the like. have.

The clip body 110 may be manufactured in a shape obtained by bending an elongated metal leaf spring at a central portion. Here, the width dimension w of the metal leaf spring constituting the clip main body 110 is inserted into the lumen 11 of the clip operation device 10 described later so that the dimension can be limited.

The clip main body 110 has self-expansion so that the clamping part 115 which will be described later will be extended to the outside in an open state when no external force is applied.

The clip body 110 is made of metal such as stainless steel and titanium alloy or plastics such as ABS resin, hard vinyl chloride resin, polyamide and polyethylene so as not to corrode in the body cavity, especially in the stomach where the digestive enzymes are secreted. It is preferable. In addition, the clip main body 110 is preferably made of a material rich in elasticity so that it can have self-expansion in normal times without an external force. In addition, when the clip body 110 is made of a polymer material, the fluorescent material 1 may be mixed into the polymer in the process of making the polymer clip, so that the clip of the polymer material may be manufactured to be fluorescent (see FIG. 6). . In addition, the surface of the clip body 110 may be formed to form a thin coating layer 3 with a polymer containing the fluorescent material 1 so that the clip itself may be fluorescent (see FIG. 7).

Clip body 110 may be composed of a proximal end 111, both arms 113 and the clamping portion (115).

The proximal end 111 is positioned on the opposite side to the living tissue (not shown) in the use state of the fluorescent display clip 100 (see FIGS. 9 and 10), and the fastening protrusion 123a of the fluorescent display unit 120 to be described later. Removably coupled.

In the present exemplary embodiment, the base end 111 exemplifies a configuration having a substantially c-shaped cross section. However, the base end 111 is not limited thereto, and the base end 111 may be fastened to the fastening protrusion 123a of the fluorescent display unit 120.

Both arms 113 are formed extending from both sides of the proximal end 111 in a thin and long direction in the direction of the living tissue, that is, the front.

Both arms 113 have a latching portion 113a on which the front end of the operation arm (or operation wire) 13 of the living body clip manipulation device 10 described later is attached, and a latching portion 113a at the rear end of the latching portion 113a. A stepped portion 113b formed to have a plate width smaller than the plate width, and a fastening ring 130 to be described later is securely engaged to maintain a fixed and tightened state of the clip, and a base end 111 and a stepped portion 113b. The concave portion 113c may be formed to be concave inwardly between the surfaces thereof to have a self-expansion. Here, it is preferable that the latching part 113a is formed in taper shape so that plate | board width may become small gradually from a front end to a rear end, and is comprised by the structure which is easy to fasten and remove the operation arm 13 mentioned later.

The sandwiching portion 115 is formed by bending the tip of both arms 113 inwardly so as to sandwich the living tissue.

Proximal end 111, both arms 113, and the clamping portion 115 constituting the clip body 110 may be manufactured in various shapes without being limited to the shape shown in the present embodiment, and can be clamped by clipping the living tissue Sufficient self-expansion structure is enough.

The fluorescent display unit 120 is provided at the rear end of the clip main body 110. As shown in FIGS. 1 and 2, the fluorescent display unit 120 is detachably coupled to the clip main body 110 or illustrated in FIG. 3. As described above, the fluorescent display unit 120 may be integrally formed on the clip body 110.

The fluorescent display part 120 may include a case 121 and a fastening part 123.

The case 121 has a storage space of a predetermined size formed therein, and is sealed by an airtight cover (not shown) after storing the photoreactive fluorescent substance 122 described later in the storage space. Here, the photoreactive fluorescent material 122 is a material that emits light itself when light is emitted from a light source of a specific wavelength band, such as a laser, LED, etc., which is harmless to the human body. As the photoreactive fluorescent material 122, nano-sized semiconductor particles (CdSe, CdTe, CdS, InAs, etc.) is a core (fluorescence quantum dot (core) dot and cyanine-based fluorescent dye (Cy3, Cy5, Cy5. 5, Cy7, etc.), and BODIPY-based fluorescent dyes (BODIPY 639 / 650-X STP ester). In particular, the fluorescent material that fluoresces in the near infrared wavelength range (600 ~ 900 nm wavelength) in response to the irradiated light is particularly useful for the use of the present invention can be efficiently used for fluorescent labeling in thick biological tissues . In addition, the photoreactive phosphor 122 may be in solid or liquid form, preferably using the photoreactive phosphor 122 in liquid form.

Since the photoreactive fluorescent substance 122 generally contains a component harmful to the human body, the case 121 is preferably secured airtight. In addition, the case 121 is preferably made of a transparent material such as glass or plastic and a light transmissive material so that light can be transmitted through the external light source to be irradiated with the photoreactive fluorescent material 122 therein.

The fastening part 123 is provided in the case 121 to fasten the case 121 having the photoreactive fluorescent material 122 to the clip body 110.

The fastening part 123 extends forward from both sides of the front end of the case 121, and fastening protrusions 123a are formed in the inward direction at each of the extended ends, so that the proximal end 111 of the clip body 110 is fastening protrusion ( It may be inserted into and fastened in 123a). Here, to facilitate the fastening of the fastening portion 123 of the case 121 and the proximal end 111 of the clip body 110, the tip of the fastening protrusion 123a is inward to prevent detachment of the case 121 after fastening. It is preferably formed to be inclined and the rear end of the fastening protrusion 123a is vertically formed. In the present embodiment, the fastening part 123 has illustrated a configuration having the shape of the fastening protrusion 123a, but is not limited thereto. Various fastening structures may be selected. For example, the fastening part 123 is configured to form a female screw (not shown) at the proximal end 111 of the clip body 110 and to form a male screw (not shown) at the tip of the case 121 to be screwed with the female screw. It is also possible.

The tightening unit 130 slides to the clip body 110 by an external force applied by the clip operating device 10 from the position mounted on the fluorescent display unit 120, and the tip clamping unit 115 of the clip body 110 is moved. By tightening the lungs to the lungs, the clip body 110 may clip the living tissue.

The tightening unit 130 may be configured as a cylindrical tightening ring (hereinafter, referred to by reference numeral 130) so as to slide on the outer diameter of the case 121 of the fluorescent display unit 120 to be movable.

The fastening ring 130 is slidably moved from the mounting position of the fluorescent display unit 120 to the clip main body 110 by external force, so that the fastening ring 130 can be stably mounted on the stepped portion 113b of the clip main body 110. The outer diameter of the case 121 of the case 121 and the plate width of the latching portion 113a of the clip body 110 is greater than the plate width of the base end 111, the stepped portion 113b, and the recess 113c of the clip body 110. It is desirable to have a smaller internal diameter. In addition, the tightening ring 130 preferably has a length corresponding to the length of the stepped portion 113b of the clip body 110.

The material of the tightening ring 130 is not particularly limited, but may be made of the same material as the clip body 110 because it is used together with the clip body 110. For example, the fastening ring 130 is preferably made of a metal such as stainless steel and titanium alloy, or a plastic material such as ABS resin, hard vinyl chloride resin, polyamide and polyethylene.

9 and 10 are cross-sectional views showing usage forms of the fluorescent display clip of the present invention, FIG. 9 is a cross-sectional view showing a state in which the fluorescent display clip of the present invention is attached to a clip operating device, and FIG. 10 is a cross-sectional view of the present invention. It is sectional drawing which shows the fixation and fastening state of a fluorescent display clip.

First, as shown in FIG. 9, the fluorescent display clip 100 of the present invention is used by being attached to the front end portion of a separately manufactured clip operation device 10. For example, the engaging portion 113a of the fluorescent display clip 100 is attached to the tip of the operation arm 13 of the clip operating device 10, and the proximal end 111 and the fluorescent display portion 120 of the fluorescent display clip 100 are mounted. ) Can be inserted into the lumen 11 of the clip manipulation device 10 so as to be moved forward and backward. Here, the clip manipulation device 10 is a device for transporting and fixing the fluorescent display clip 100 in which the photoreactive fluorescent substance 122 is embedded to a target position in the biological tissue of the patient. Since the clip manipulation device 10 can be understood by a known technique, detailed description thereof will be omitted.

Next, as shown in FIG. 10, first, the fluorescent display clip 100 mounted on the distal end portion of the clip manipulation device 10 is transferred to a target site in a living tissue such as a large intestine or a stomach. In the state where the fluorescent display clip 100 reached the target position by the clip operation device 10, the latching portion 113a of the fluorescent display clip 100 is pulled back by pulling the operation arm 13 of the clip operation device 10 backward. ) To fix the fluorescent display clip 100 to the desired position. In addition, by pulling the operation arm 13, both arm portions 113 of the clip main body 110 are slowly introduced into the inner diameter of the tightening ring 130 from the proximal end 111 side, and the tightening ring 130 is the clip main body ( When drawn to the position of the stepped portion 113b of the 110, the tightening ring 130 is caught and stopped by the stepped portion 113b, and the clamping portion 115 at the tip of the clip main body 110 comes into contact with the living tissue not shown. Cooperate. At this time, the clip main body 110 in the closed state is fastened to the fastening ring 130 is securely fixed to the step portion 113b, the clip main body 110 is a living body for a long time regardless of the size of the biological tissue to be pinched It can keep the organization in a narrow state.

Finally, when the fixing and tightening of the fluorescent display clip 100 is finished, the operation arm 13 is detached from the latching portion 113a, the clip operation device 10 is pulled out of the body, and the photoreactive fluorescent substance 122 is removed. Only this embedded fluorescent display clip 100 is left at the target site in the living tissue.

As such, by combining the fluorescent display unit 120 having the photoreactive fluorescent material 122 embedded in the rear end of the clip main body 110, the light source having a specific wavelength band from the outside after clipping and fixing to the surgical site of the biological tissue The photoreactive fluorescent substance 122 emits light to find the exact position of the fluorescent display clip 100 in the body easily and quickly.

Therefore, when the fluorescent display clip 100 of the present invention is used, the treatment area can be minimized during treatment of colorectal cancer, gastric cancer, etc., and the side effects due to excessive incision can be minimized. In addition, the fluorescent display clip 100 of the present invention is a placeholder that can easily and quickly find a desired area during various surgical procedures in addition to gastric cancer and colorectal cancer treatment, its application field is very wide. In addition, since the light source such as laser, LED, etc., which is harmless to the human body, is used for locating the photoreactive fluorescent substance 122 added to the clip main body 110, the operation of the patient has little effect, and the clip manipulation device 10 And through the miniaturization of the light source device (not shown), it is possible to apply to existing laparoscopic surgery as it is.

Although embodiments of the present invention have been described above with reference to the accompanying drawings, those skilled in the art to which the present invention pertains may implement the present invention in other specific forms without changing the technical spirit or essential features thereof. I can understand that. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive. The scope of the present invention is shown by the following claims rather than the above description, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be construed as being included in the scope of the present invention. do.

100: fluorescent display clip 110: clip body
111: proximal end 113: both arms
113a: step portion 113b: step portion
113c: recess 115
120: fluorescent display 121: case
122: fluorescent material 123: fastening portion
130: tightening part (fastening ring)

Claims (1)

A clip body having self-expansion; And
And a tightening part which slides to the clip main body by external force from a proximal end and tightens the tip of the clip main body in a closed manner.
The clip body is made of a material that is mixed with a photoreactive fluorescent material or a fluorescent display clip for surgery, characterized in that the photoreactive fluorescent material coated on the surface of the clip body.

Images