KR101249051B1 - Method for manufacturing Implant being harmony with a living body - Google Patents

Abstract

The present invention relates to a method for producing a biocompatible implant.
The present invention comprises the steps of: i) preparing an apatite hydroxide composite powder in which silver powder is dispersed in an apatite hydroxide powder; Ii) supplying a carrier gas of any one of nitrogen, argon, helium, hydrogen gas or a mixture thereof; Iii) supplying the apatite hydroxide composite powder in which particles are classified in a state in which it is not in contact with the atmosphere while moving with the carrier gas on a closed circuit in which the supplied carrier gas moves; Ⅳ) forming a coating layer by the vacuum chamber is a high speed collision in the implant-type base metal production is the apatite hydroxide composite powder to be supplied is reduced to less than 10 ^-1 torr to titanium or titanium alloy; It provides a method for producing a biocompatible implant comprising a.

Description

Method for manufacturing Implant being harmony with a living body}

The present invention relates to a method for producing a biocompatible implant, and more particularly, a thin film of a composite of a combination of hydroxyapatite (hydroxyapatite) (hereinafter referred to as "HA") having excellent biocompatibility and silver having excellent antimicrobial activity on a titanium implant, and an implant and a coating layer The present invention relates to a method for producing an implant having excellent adhesion with and excellent in biocompatibility and antibacterial properties.

Since the implant is an artificial tooth that permanently replaces the missing tooth, the implant should play the same role as the actual tooth when chewing the actual food, and at the same time, it should be manufactured to properly distribute the load on the tooth. In addition, the implant should be able to play a more stable role than the existing dentures.

Therefore, implants for artificial teeth should be selected for materials that have very high biocompatibility for living tissue when implanted into the alveolar bone in the oral cavity, and should select materials that do not have biochemical side effects with existing living tissue.

In addition, mechanical strength should be excellent so that deformation and breakage do not occur in the case of repeated mastication and instantaneous loads during the mastication of hard foods, as well as normal mastication movements.

In addition, after infection in the implants and alveolar bone and food residues between the teeth and implants, secondary infection is not made, and bone adhesion to the implants is required within a short time for convenience after the procedure.

In order to achieve this demand, there is a need to coat the surface of the implant to be implanted into a living body material having excellent bone adhesion to existing living tissue.

Among these materials, HA crystals are known to be biocompatibility superior to any materials known to be a major component constituting bone components in the human body.

Therefore, efforts to improve biocompatibility, shorten osteoadhesion and osteoadhesion period by coating HA through various methods have been suggested through various documents.

Among them, there is a nanostructured HA coating method (J. Biomed. Mater. Res., 59, 312-317, 2002) doped with yttrium (Y) in order to enhance bone adhesion strength. Another method is to impregnate collagen fibers with nanoscale HA crystals (Biomedical Engineering Handbook, pp. 274, 1995).

In addition, a method of melting and coating HA crystals using plasma is also used (International Thermal Spray Conference, 28-30 May, 2001, Singharpore pp. 105). In this method, however, the HA crystals are pyrolyzed due to the high temperature of the plasma, resulting in the formation of a second phase (a-TCP, b-TCP, CaO, amorphous) other than HA, which results in poor biocompatibility of the HA plasma coating. It can also cause consequences. Another defect is that the adhesive support (usually Ti-6Al-4V alloy) and the adhesive strength is low, it is difficult to secure the reliability of the dental implant coating.

In order to overcome this problem and improve the adhesion strength of the coating layer and the formation of the second phase during coating, a method of coating the HA powder by the high-speed spraying method (International Thermal Spray Conference, 28-30 May, 2001, Singapore pp. 245 )

However, this method also lowers the thermal decomposition degree and improves the adhesive strength of the coating layer compared to the plasma coating, but the amorphous phase formed during the coating is selectively dissolved in the SBF (simulated body fluid) solution, causing a significant drop in the adhesive strength of the coating layer.

As described above, when HA is coated using a high temperature heat source, an undesired second phase is formed in the coating layer, thereby degrading the biocompatibility of the HA coating.

To overcome this drawback, a method of growing HA directly on an implant support in SBF solution (Journal of Materials Science: Materials in Medicine 14 (2003): 539: 545) is presented. However, this method is still at the research level due to the low adhesive strength with the support.

The HA powder-coated implant according to various methods as described above has a merit that the HA implant can be quickly adapted to the alveolar bone in the oral cavity and has high adhesion to the alveolar bone around the implant. In addition, these implants have the advantage that they do not cause problems such as physiological and immunological stability that may occur in the metal implants for a long time, HA-coated composite metal implants can solve various problems that may exist in patients after the procedure It is expected to be.

However, HA implants, as mentioned above, form HA coating layers that are chemically non-uniform due to phase decomposition of HA crystals due to the high temperature coating process, and the second phases formed after prolonged in vivo are decomposed or There is a problem that it is difficult to adhere the solid alveolar bone to the implant surface is absorbed.

In addition, the HA coating layer of the existing HA-coated implant is not suitable for use as an implant having a strong and dense coating layer required by the dentist because the adhesive strength with the implant is only about 23 ㅁ 2 MPa. Therefore, existing HA implants are known to be excellent in initial reactivity but unsuitable for long-term clinical application.

Recently, in order to solve this problem, technologies that partially solve these problems have appeared by coating HA powder at room temperature.

However, these technologies have a problem that there is no mention of the HA powder distribution effective for controlling or coating the coating to have a uniform particle size distribution or uniform particle size of the HA powder to be used.

In addition, the use of these techniques does not participate in the actual coating, but rather the problem that the nozzle may be frequently clogged during the HA coating process by the HA powder having a large particle that adversely affects the HA coating layer properties.

On the other hand, silver (Ag) has a strong bactericidal and antimicrobial power, harmless to the human body is used in a variety of health products and is also a very popular material for use in implants. Therefore, there is an urgent need for a process design for manufacturing an implant having excellent HA coating properties and securing antimicrobial properties by silver.

It provides a method for producing an implant having excellent HA coating properties and antimicrobial properties by silver.

In addition, the particle size distribution of the HA powder effective for coating can be easily controlled to provide a method for producing an implant having excellent HA coating properties.

One embodiment of the present invention, the method comprising the steps of: i) preparing an apatite hydroxide composite powder in which silver powder is dispersed in an apatite hydroxide powder; Ii) supplying a carrier gas of any one of nitrogen, argon, helium, hydrogen gas or a mixture thereof; Iii) supplying the apatite hydroxide composite powder in which particles are classified in a state in which it is not in contact with the atmosphere while moving with the carrier gas on a closed circuit in which the supplied carrier gas moves; Ⅳ) forming a coating layer by the vacuum chamber is a high speed collision in the implant-type base metal production is the apatite hydroxide composite powder to be supplied is reduced to less than 10 ^-1 torr to titanium or titanium alloy; It provides a method for producing a biocompatible implant comprising a.

The composite powder is preferably prepared by adding apatite hydroxide powder and silver powder to any one of distilled water and alcohol, rotating mixing with a mixer, drying, and separating the dried mixed powder by vibration. At this time, drying can be performed by a spray drying method.

In addition, when preparing a composite powder, it is preferable to add 0.001-45 weight% silver powder and remainder apatite hydroxide powder, More preferably, it is 0.001-10 weight% silver powder and remainder apatite hydroxide powder.

The silver powder preferably has a particle size in the range of 1 to 200 nm, and preferably 50% or more of the silver powder has a particle size in the range of 1 to 10 nm.

The classified apatite hydroxide composite powder is preferably in the particle size of 100nm ~ 30㎛ range, more preferably 100nm ~ 10㎛. In addition, it is preferable that the apatite hydroxide composite powder is classified by a particle size classifier with a built-in cyclone device.

The coating layer preferably has a porosity of 1% or less.

Dental implants prepared according to an embodiment of the present invention is coated using a HA composite powder is dispersed silver has the effect of exhibiting excellent antibacterial function of silver.

In addition, a second phase such as pores is not formed in the HA composite coating layer, and excellent adhesion with a metal implant has a technical effect of effectively implementing excellent biocompatibility characteristics of HA.

In addition, the HA-coated implant prepared according to an embodiment of the present invention has a technical effect that can be stably present in the human body because of the fast recovery rate of the patient after the procedure and excellent bone bonding strength with the alveolar bone even for long-term use.

In addition, an embodiment of the present invention has a technical effect of providing an implant manufacturing method for controlling the particle size distribution of the HA complex powder so that the stable HA complex is coated.

1 is a device for thin-film coating the HA composite powder on a titanium implant according to an embodiment of the present invention.
Figure 2a is a diagram showing the particle size distribution of the initial HA composite powder stored in the hopper in one embodiment of the present invention.
Figure 2b is a diagram showing the particle size distribution of the HA composite powder classified in particle size in one embodiment of the present invention.
Figure 3 is a scanning electron micrograph of the coating layer coated under the conditions of Comparative Example 1 when the particle size classifier is not used.
Figure 4 is a scanning electron micrograph of the coating layer coated under the conditions of Example 1 when the particle size classifier according to an embodiment of the present invention.
5 is a diagram showing an X-ray diffraction pattern of the HA composite coating layer prepared using a particle size classifier according to an embodiment of the present invention.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the invention. As used herein, the singular forms “a,” “an,” and “the” include plural forms as well, unless the phrases clearly indicate the opposite. As used herein, the term "comprising" embodies a particular characteristic, region, integer, step, operation, element, and / or component, and other specific characteristics, region, integer, step, operation, element, component, and / or group. It does not exclude the presence or addition of.

Unless defined otherwise, all terms including technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. Commonly used predefined terms are further interpreted as having a meaning consistent with the relevant technical literature and the present disclosure, and are not to be construed as ideal or very formal meanings unless defined otherwise.

Hereinafter, embodiments of the present invention will be described in detail. These embodiments are only for illustrating the present invention, and the present invention is not limited thereto.

The material of the implant used in the present invention is made of titanium or an alloy thereof. Titanium is simple to process, relatively lighter than other metals, and may be made of alloys with other metals or by heat treatment to improve mechanical strength.

Such titanium or titanium alloy forms a dense passivation oxide film in the air or in water and has great corrosion resistance, and has excellent merit of adhesion with bone when inserted into the bone. Hereinafter, an implant made of titanium or a titanium alloy is defined as a titanium implant.

Silver is a material with strong bactericidal and antimicrobial properties. A silver particle having a particle size in nanometers is commonly referred to as silver nano powder.

The silver powder used in the present invention has a particle size of 1 to 200 nm, preferably 1 to 10 nm of which contains 50% or more. Since the specific surface area becomes too small when the particle size of silver powder is out of the range mentioned above, it limits to the range mentioned above.

An HA composite powder in which such silver powder is evenly dispersed in the HA composite powder is used. The content of silver powder dispersed in the HA composite powder is 0.001 to 45% by weight, more preferably 0.001 to 10% by weight. It is preferable that the dispersibility of the silver powder is high, that is, the silver powder is uniformly dispersed in the HA composite powder as uniformly as possible.

1 is a device for thin film coating HA composite particles on a titanium implant according to an embodiment of the present invention.

The apparatus for producing biocompatible implants used in the present invention

Iii) a gas tank storing a carrier gas of any one of nitrogen, argon, helium, hydrogen gas or a mixture thereof;

Ii) a hopper through which the carrier gas discharged from the gas tank passes and stores HA composite powder;

Iii) a spray nozzle for injecting the HA composite powder stored in the hopper and carried by the carrier gas at high speed into an implant-type base metal made of titanium or a titanium alloy;

A vacuum chamber incorporating the spray nozzle and maintaining a reduced pressure to 10 ⁻¹ torr or less by a pump; And

Iv) the gas tank and the vacuum chamber form a closed circuit and are installed between the hopper and the vacuum chamber to classify particles in a state in which the HA composite powder is not in contact with the atmosphere; It is made, including.

In addition, the particle size classifier

Iii) a carrier gas supply line including HA composite powder;

Ii) a conical plate for flowing the HA composite powder supplied from the supply pipe outward from the particle size classifier;

Iii) a gap formed between the outer wall of the particle size classifier and the conical plate;

Iii) an auxiliary carrier gas supply pipe for supplying an auxiliary carrier gas in the gap direction;

Iii) a cyclone gap in which the HA composite powder, which is carried by the auxiliary carrier gas, is conveyed;

Iii) a discharge pipe for discharging the HA composite powder having a small particle size into the vacuum chamber; .

Hereinafter, a method of coating the HA composite powder on the titanium implant by using the apparatus for manufacturing such biocompatible implant will be described.

For the preparation of the HA composite powder, first, HA powder and silver powder are added to distilled water or alcohol and mixed by rotation with a mixer. At this time, silver powder is added in an amount of 0.001 to 45% by weight, and the remainder is added in an amount that becomes HA powder. More preferably, the silver powder is added in an amount of 0.001 to 10% by weight and the remaining HA powder.

The powder mixed by rotation with a mixer is dried. At this time, drying by the spray drying method may enhance the dispersing effect of the silver powder.

Preparation of the HA composite powder is completed by separating the dried composite powder from the HA composite particles and the particles by mechanical vibration. At this time, the strength of vibration is controlled to the extent that the HA composite powder particles are separated from each other, and the vibration is too strong so that the particles are not crushed.

For thin film coating using the HA composite powder thus prepared, as shown in FIG. 1, first, the carrier gas 13 is discharged from the gas tank 10 and passed through the hopper 16 containing the HA composite powder. The fine HA composite powder is introduced into the vacuum chamber 19 together with the carrier gas 13. The flow rate of the carrier gas 13 discharged at this time is controlled by the mass flow meter 15.

The usable carrier gas 13 may use one of nitrogen, argon, helium, hydrogen gas, or a mixed gas thereof, and the temperature of the carrier gas is maintained at 100 ° C. or less.

In addition, a closed circuit is formed from the gas tank 10 to the vacuum chamber 19 so that the inside of the closed circuit is isolated from the outside and does not come into contact with the atmosphere.

In addition, the vacuum chamber 19 is maintained at a very low pressure reduced to 10 ⁻¹ torr or less by the booster pump 17 and the rotary pump 18. Therefore, the HA composite powder of the carrier gas 13 and the fine grains introduced from the hopper 16 impinges on the specimen 20 at a very high speed through the spray nozzle 12. Here, the specimen 20 refers to a titanium implant or a specimen having such a material.

In one embodiment of the present invention, a particle size classifier 14 is provided between the hopper 16 and the vacuum chamber 19. The particle size classifier 14 classifies the particle size of the HA composite powder discharged by the carrier gas 13 from the hopper 16, and then transfers only the powder in the range of 100 nm to 30 μm to the vacuum chamber 19. The more preferable range of the classified HA composite powder is 100 nm to 10 mu m. To this end, the particle classifier 14 has a built-in cyclone device.

The particle size classifier 14 is provided with a supply pipe 36 to supply the carrier gas containing the HA composite powder into the particle size classifier 14 through the supply pipe. The HA composite powder supplied to the particle size classifier 14 flows inside the classifier and flows outward from the inside of the size classifier along the conical plate (see FIG. 1). At this time, the HA composite powder flows between the gap formed between the outer wall of the particle size classifier 14 and the outside of the inner cyclone group 34, and the particle size is increased by the auxiliary carrier gas supplied to the external auxiliary carrier gas supply pipes 31 and 32. The small HA composite powder flows into the cyclone group 34 along the cyclone gap 33. On the other hand, the HA composite particles having a large particle size do not move to the cyclone gap 33 by the auxiliary carrier gas and fall down to the classifier 14. By this process, the particle size of the HA composite powder is classified, and at this time, the particle size classification of the HA composite powder can be controlled by adjusting the gas flow rate of the supplied auxiliary carrier gas. For this purpose, the supply pipes 31 and 32 through which the auxiliary carrier gas flows are further Mass flow meter 39 is installed to control the flow rate supplied.

As described above, the HA composite powder having a small particle size classified by the particle size classifier 14 is carried in the carrier gas 13 and the auxiliary carrier gas and transported to the vacuum chamber 19 along the discharge pipe 37. The composite powder is accumulated at the bottom of the classifier 14.

If it does not pass through the particle size classifier 14 as in one embodiment of the present invention, the HA composite powder stored in the hopper 16 is initially equal to the particle size distribution of the powder stored in the hopper. The particle size of the initial powder stored in the hopper 16 has a very wide particle size distribution as shown in FIG. 2A.

As described above, the HA composite powder having a wide particle size distribution is also discharged with a large particle therein, so that when it collides with the specimen 20 at high speed, it is difficult to coat the specimen and may remain in the powder layer in the coating layer.

Therefore, the coating layer formed when the HA composite powder in a state in which the particle size is not controlled on the specimen has bubbles, or the coating layer is uneven, which adversely affects the adhesive properties.

In addition, the HA composite powder is very small in size and very sensitive enough to exhibit coagulation even in a very small amount of moisture present in the atmosphere. Therefore, when the particle size is classified outside the coating apparatus that can contact the HA composite powder with the atmosphere, moisture in the air flows into the HA composite powder in the process of being introduced into the coating apparatus, whereby the HA composite powder is agglomerated (agglomerates). . If the HA composite powder is pre-classified outside the coating apparatus, not only this aggregation problem but also various contamination problems due to contact with the classifier inner wall may be caused.

Based on this, in one embodiment of the present invention, the particle size classifier 14 is provided between the hopper 16 and the vacuum chamber 19 in order to classify the supplied HA composite powder into the required particle size without contacting the atmosphere. . In this way, the HA composite powder having a uniform particle size classified by the body size classifier 14 which blocks the possibility of contact with the atmosphere is supplied to the vacuum chamber 19.

In this case, the particle size distribution of the HA composite powder that has passed through the particle size classifier 14 is illustrated in FIG. 2B.

The HA composite powder having a particle size as described above is discharged onto the specimen 20 through the spray nozzle 12 in which the fine holes are formed in the vacuum chamber 19, and at this time, due to the pressure difference before and after the nozzle 20. The HA composite powder is further accelerated to impinge on the titanium implant surface, ie the surface of the specimen, to form an HA coating layer.

As such, when the HA composite powder collides with the specimen 20 at high speed, the classified fine HA composite powder becomes microfracture into finer powder, and the finely broken HA composite powder forms an HA composite coating layer on the titanium implant. To start. This coating method is one of the low temperature high-speed impact coating method.

The HA composite coating layer formed in this manner controls the biaxial feed and rotary device 11 through the biaxial controller 23 and the computer 22, and controls the thickness of the HA composite coating layer coated on the titanium implant through this control. I can regulate it.

At this time, the thickness of the coating layer coated on the titanium implant is preferably in the range of 50nm ~ 30㎛. More preferably, the thickness of the coating layer is adjusted to within the range of 100nm ~ 5㎛. In this way, the thickness of the coating layer is limited so that the HA composite coating layer improves mechanical stress transfer interworkability after bone adhesion and is not easily peeled off even after the procedure.

The coating method as described above enables the HA composite coating layer to be formed on the titanium implant without applying a high temperature heat source to the coating material.

Hereinafter, the present invention will be described in more detail with reference to experimental examples. These experimental examples are only for illustrating the present invention, and the present invention is not limited thereto.

<Production of HA Complex Powder>

The size of the HA composite powder coated on the titanium implant surface must be sufficiently fine to float in the carrier gas 13 passing through the hopper 16.

Preferred sizes of the HA composite powder range from 100 nm to 10 μm as a result of repeated experiments. It was confirmed that the HA composite powder having particles in this range could sufficiently flow from the hopper into the vacuum chamber by the flow rate of the carrier gas.

Since the particle size of the silver powder is negligibly small compared to the HA powder, the particle size of the HA composite powder is determined by the particle size of the HA powder. In order to prepare the HA composite powder having a size in the above-described range, the HA powder in the range of 10 ~ 100㎛ purchased was ball milled until the size of the HA powder is sufficiently small by a ball milling method. The ball milling time was adjusted by adjusting the ball milling time to stop the ball milling when the powder distribution of the desired size was the most and set the time as the optimum ball milling time. The optimum ball milling time in this test example was 54 hours.

Next, silver powder had a particle size of 1 to 200 nm, and about 60% of the particles were prepared to have a particle size of 1 to 10 nm.

5 wt% of the silver powder and 95 wt% of the HA powder thus prepared were added to alcohol, mixed with a mixer, and dried by a spray drying method to uniformly disperse the silver powder in the HA powder. Then, mechanical vibration was applied to separate the HA composite particles and the particles from each other.

<HA composite coating>

The prepared HA composite powder was introduced into the hopper 16, and the booster pump 17 and the rotary pump 18 were operated to reduce the vacuum chamber 19.

Decompression of the vacuum chamber 19 was carried out until the pressure in the chamber reached the range of 10 ^-2 to 10 ^-3 torr.

When this pressure was reached, the flow meter 15 was controlled to allow 10-100 L / min. Of carrier gas 13 to flow into the hopper 16. At this time, the hopper 16 is already connected to the vacuum chamber 19, which shows a low pressure. The carrier gas 13 introduced at 1 atm generates turbulence in the hopper 16, and thus the HA composite powder moves to the particle size classifier 14 together with the carrier gas.

The particle size classifier 14 is equipped with an internal cyclone device, so that the introduced HA composite powder is classified in the range of 100 nm to 30 μm. When the HA composite powder having such a particle size is used, the coating layer formed on the titanium implant surface is dense and there is no defect in the contact layer.

As described above, the HA composite powder introduced into the vacuum chamber 19 is discharged through the spray nozzle 12 having a fine hole. At this time, the HA composite powder is further accelerated due to the pressure difference between the front and rear of the nozzle. It collides to form an HA composite coating layer.

The HA composite coating layer formed as described above controls the biaxial feed and rotary device 11 through the biaxial controller 23 and the computer 22 and adjusts the thickness of the HA composite coating layer coated on the titanium implant through this control.

The thickness of the coating layer formed by the above method was about 100 nm-5 micrometers.

<Analysis of HA Composite Coating Layer>

Table 1 below shows the porosity of the HA composite coating layer and the adhesion strength with the titanium implant for the case of using the particle size classifier 14 according to the embodiment of the present invention and the case of the case where it is not.

The porosity of the coating layer measured in one embodiment of the present invention was measured according to ASTM E2109.

Changes in Coating Layer Characteristics by Particle Classifier division Granularity
Classifier Carrier Gas Flow
(l / min) Coating distance (mm) Porosity (%) Adhesive Strength (kgf / cm ² ) Example 1 High Speed Collision Coating use 20 10 0.7 530 Example 2 High Speed Collision Coating use 20 7 0.5 565 Example 3 High Speed Collision Coating use 30 7 0.4 662 Comparative Example 1 High Speed Collision Coating unused 20 10 1.5 515 Comparative Example 2 High speed collision coating unused 20 7 1.9 522 Comparative Example 3 High speed collision coating unused 30 7 1.3 536 Comparative Example 4 Plasma Coating
- - 80 8-13 230 Comparative Example 5 Biomimetic HA Coating - - - - 12 Comparative Example 6 Sol-Gel Coating - - - - 53

As shown in Table 1, it can be seen that the adhesive strength of the HA composite coating layer increases when a particle size classifier is used, and the porosity of the coating layer is very low.

The porosity of the coating layer is closely related to the thickness uniformity of the coating layer when the powder collides at high speed to form the coating layer. This occurs when large particles that cause pores in the coating layer attempt to participate in the coating layer. At this time, pores tend to form around the large particles. Titration tends to be thicker than where the coated particles are, which can reach 6 µm.

Therefore, the porosity of the coating layer of about 1.0% or less as in the embodiment means that the participation of the coating by such a large particle is very small, thereby improving the uniformity of the thickness of the coating layer to 1㎛ ± 0.5㎛.

3 shows a scanning electron micrograph of the coating layer coated under the conditions of Comparative Example 1 when the particle size classifier 14 is not used.

 4 shows a scanning electron micrograph of the coating layer coated under the conditions of Example 1 in the case of using the particle size classifier 14 according to an embodiment of the present invention.

As apparent from FIG. 3 and FIG. 4, in the case of Comparative Example 1, many pores are included in the HA composite coating layer, whereas in Example 1, such defects do not appear and the coating thickness is uniform, and Adhesive strength also forms an improved quality coating.

As can be seen from the experimental results, the HA composite coating layer formed when the particle size classifier 14 according to the exemplary embodiment of the present invention is used has an extremely low porosity to form a dense coating layer with the titanium implant.

In addition, as shown in FIG. 5, the HA composite coating layer prepared using the particle size classifier has a very thin coating layer, and thus shows a diffraction pattern of the base metal, and the diffraction pattern of the second phase except for the HA diffraction pattern and the silver diffraction pattern is shown as a component of the coating layer. Therefore, it could be seen that the use of the particle size classifier did not affect the crystallinity of the HA composite coating layer.

In addition, the HA composite-coated titanium implant prepared according to one embodiment of the present invention exhibits very high adhesive strength compared to conventional HA coating by plasma coating, biomimetic HA coating, and sol-gel method.

These results indicate that the HA composite coating layer can form a very good HA composite coating layer when the HA composite coating is continuously coated, and the second phase does not appear even in the HA composite coating layer formed through such a continuous process. It can be usefully used as a dental medical device.

While the invention has been shown and described with reference to certain exemplary embodiments thereof, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the scope of the following claims. Those who do it will easily understand.

10: gas tank 13: carrier gas
15: Flowmeter 16: Hopper
17: booster pump 18: rotary pump
19: vacuum chamber 20: specimen
31: carrier gas supply pipe 33: cyclone clearance
34: cyclone group 37: discharge pipe

Claims (11)

Preparing an apatite hydroxide composite powder obtained by dispersing silver powder in an apatite hydroxide powder;
Supplying a carrier gas of any one of nitrogen, argon, helium, hydrogen gas, or a mixture thereof;
Supplying the apatite hydroxide composite powder in a state in which the particles are classified and not aggregated in a state in which the supplied carrier gas moves together with the carrier gas on the closed circuit in which the supplied carrier gas moves and does not come into contact with moisture in the atmosphere;
The vacuum chamber is a step of forming a coating layer having a porosity of 1% or less by colliding at high speed to the implant-type base metal made of titanium or titanium alloy is supplied to the apatite hydroxide composite powder supplied under reduced pressure below 10 ^-1 torr;
Method of producing a biocompatible implant comprising a. The method of claim 1,
The composite powder is prepared by adding the apatite hydroxide powder and the silver powder to any one of distilled water and alcohol, rotating mixing with a mixer, drying, and separating the dried mixed powder by vibration. Way. The method of claim 2,
The said drying is a manufacturing method of a biocompatible implant performed by the spray drying method. The method of claim 2,
A method for producing a biocompatible implant, wherein the silver powder is added in an amount of 0.001 to 45% by weight, and the remainder is apatite hydroxide powder. The method of claim 2,
A method for producing a biocompatible implant comprising adding 0.001 to 10% by weight of the silver powder and the remainder of the apatite hydroxide powder. The method of claim 1,
The silver powder has a particle size of 1 ~ 200nm range of the biocompatible implant manufacturing method. The method according to claim 6,
50% or more of the silver powder has a particle size of 1 ~ 10nm range of biocompatible implant manufacturing method. The method of claim 1,
The classified apatite hydroxide composite powder is a method of producing a biocompatible implant having a particle size of 100nm ~ 30㎛ range. The method of claim 1,
The classified apatite hydroxide composite powder is a method of producing a biocompatible implant having a particle size of 100nm ~ 10㎛ range. 9. The method of claim 8,
The apatite hydroxide composite powder is classified by a particle size classifier with a built-in cyclone device. delete

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