KR101162459B1 - The sorption column assembling - Google Patents

The sorption column assembling Download PDF

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Publication number
KR101162459B1
KR101162459B1 KR20100126376A KR20100126376A KR101162459B1 KR 101162459 B1 KR101162459 B1 KR 101162459B1 KR 20100126376 A KR20100126376 A KR 20100126376A KR 20100126376 A KR20100126376 A KR 20100126376A KR 101162459 B1 KR101162459 B1 KR 101162459B1
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South Korea
Prior art keywords
sealing member
column
glass container
needle
adsorbent
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KR20100126376A
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Korean (ko)
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KR20120065056A (en
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백승삼
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주식회사 삼영유니텍
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Publication of KR20120065056A publication Critical patent/KR20120065056A/en
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Abstract

The present invention relates to a column for generating a cancer diagnostic agent of a radiopharmaceutical, and more particularly, to a medicine containing radioactive substance in an aqueous solution which is used for cancer diagnosis. The present invention relates to a column for generating a cancer diagnostic agent for radiopharmaceuticals, which can prevent breakage and improve the adsorption efficiency of the adsorbent.
That is, the present invention comprises a glass container made of a rod-shaped tubular body and provided with a transparent body, an adsorbent filled in a powder form inside the glass container, and an upper and lower filters in contact with each other to maintain the form stability of the adsorbent. And a porous support plate having a plurality of through holes formed to be in close contact with the bottom of the lower filter, and a sealing member made of silicon at the upper and lower ends of the glass container, respectively, but having an outer diameter of the glass container outside the locking jaw of the sealing member. And a column for generating a cancer diagnostic agent for radiopharmaceuticals formed by forming a protruding end portion provided with a large diameter and an expandable guide groove on the inner surface of the sealing member.

Description

Column for generating cancer diagnostic agent of radiopharmaceuticals {The sorption column assembling}

The present invention relates to a column for generating a cancer diagnostic agent of a radiopharmaceutical, and more particularly, to a medicine containing radioactive substance in an aqueous solution which is used for cancer diagnosis. The present invention relates to a column for generating a cancer diagnostic agent for radiopharmaceuticals, which can prevent breakage and improve the adsorption efficiency of the adsorbent.

Although cancer diagnostic agents in radiopharmaceuticals generally tend to avoid radiation from radioactive materials, the reason for such high usage is that radioactive materials have a unique characteristic of having high permeability. It is developing rapidly.

When using a cancer diagnostic agent of radiopharmaceuticals, in consideration of stability, a column for generating a cancer diagnostic agent is supplied to a company in order to generate a cancer diagnostic injection solution. so the adsorbent is filled into the container is to maintain the shape stability to the filter, and both ends of the glass container, but using these cancer diagnosis column coupled to the closure member that can be fitted to the needle Hexi molybdenum on the inside of the glass container (Mo - 99 ) with an adsorbent obtained by adsorbing alumina packed in the form of sodium molybdate and a column equipped with a filter.In the case of using a cancer diagnostic agent, a reactant made of Nacl or the like is injected into the column to adsorbent. the reaction process generates tekeune ryumsan sodium (Tc -99m) and that in passing in contact with the elution using a cancer diagnostic agent consisting of an injection solution And there.

Conventional cancer diagnostic column was covered with a ring-shaped escape prevention cap made of alumina around the sealing member coupled to both ends of the glass container to be fixed to the organic container bar, in the process of transporting or storing such cancer diagnostic column Not only did the glass container be damaged by the impact generated when the protruding alumina release cap is in contact, but also the needle bent in one direction with the needle bent at least one step into the sealing member. It was inconvenient to use because it could not be fixed.

In addition, in the conventional cancer diagnostic column, since the inner surface of the sealing member located inside both ends of the glass container is in a state of being in close contact with the felt-type filter, the reactant injected into the filter through the needle inserted into the sealing member is removed from the filter. Since the contact with the adsorbent in the form of eccentricity through one side is not evenly distributed to the adsorbent, the adsorption efficiency is reduced.

In order to solve this problem, the column for generating a cancer diagnostic agent of a radiopharmaceutical is combined with a sealing member made of silicon on both ends of the glass container, but has a protruding end with a diameter larger than the outer diameter of the glass container on the outside of the locking jaw. In addition, it has a protective function of the glass container and forms an expansion pipe guide groove on the inner side of the sealing member located inside both ends of the glass container of the cancer diagnostic column, and the reactant injected through the sealing member spreads widely through the filter to the adsorbent. As a means of contacting to increase the adsorption efficiency, and also to elute the injection solution is eluted to the center to increase the elution efficiency.

In addition, the present invention is provided with a needle insertion groove on the outer surface of the sealing member to be inserted in the needle insertion groove bent portion of the needle bent in more than one stage to fix the bent installation direction of the needle.

The present invention comprises a glass container made of a rod-shaped tubular body and provided with a transparent body, an adsorbent filled in a powder form inside the glass container, and an upper and lower filters in close contact to maintain the form stability of the adsorbent, Combine the porous support plate with a plurality of through holes formed in close contact with the bottom of the lower filter and the sealing member made of silicon on the upper and lower ends of the glass container, respectively, the diameter larger than the outer diameter of the glass container outside the locking jaw of the sealing member. And a column for generating a cancer diagnostic agent of a radiopharmaceutical formed by forming a protruding end portion and an expansion-shaped guide groove on the inner surface of the sealing member.

The column for generating the cancer diagnostic agent of the radiopharmaceutical of the present invention is formed at the upper and lower portions of the glass container with a diameter larger than the outer diameter of the glass container on the outside of the locking jaw of the sealing member to prevent breakage of the glass container. In addition, expansion pipe guide grooves are formed on the inner side of the sealing member, respectively, and the reactants injected through the upper sealing member are uniformly contacted with the adsorbent to greatly increase the adsorption efficiency, and the injection solution eluted through the lower filter is focused. To facilitate elution.

In addition, the present invention has an effect such that the needle insertion groove is formed on the outer surface of the upper, lower sealing member to ensure the safe and convenient use of the needle and to accurately insert the tip of the needle into the center of the sealing member. have.

1 is a perspective view showing a column for generating a cancer diagnostic agent of a radiopharmaceutical according to the present invention.
Figure 2 is a partially cut perspective view showing a sealing member coupled to the upper and lower parts of the glass container of the column for generating cancer diagnostic agents of the radiopharmaceutical according to the present invention.
Figure 3 is a partially cut perspective view showing the overall configuration of the column for producing a cancer diagnostic agent of a radiopharmaceutical according to the present invention.
Figure 4 is a longitudinal sectional view showing the configuration of a column for producing a cancer diagnostic agent of a radiopharmaceutical according to the present invention.
Figure 5 is an exemplary cross-sectional view illustrating a state of use of the column for producing cancer diagnostics of radiopharmaceuticals according to the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the following description of the present invention, if it is determined that a detailed description of a related known function or configuration may unnecessarily obscure the subject matter of the present invention, the detailed description thereof will be omitted.

The column (A) for generating a cancer diagnostic agent of a radiopharmaceutical of the present invention includes a glass container 10 made of a rod-shaped tube and provided with a transparent body, and an adsorbent filled in a powder form inside the glass container 10 ( 20) and a plurality of upper and lower felt filters 30 and 30 'that are in close contact with each other to maintain the shape stability of the adsorbent 20, and a plurality of the upper and lower felt filters that are installed in close contact with the bottom of the lower filter 30'. The porous support plate 40 having a through hole and the sealing members 50 and 50 'of silicon are respectively coupled to the upper and lower ends of the glass container 10, but the locking jaws of the sealing members 50 and 50' are combined. (52) Protruding end portion 54 provided with a diameter larger than the outer diameter of the glass container on the outside and expansion guide grooves 58 formed on the inner surface of the sealing members 50, 50 ', respectively. It features.

In addition, the present invention is provided with a needle insertion groove 56 on the outer surface of the sealing member (50, 50 ') to fit the bent portion 62 of the needle 60 bent in one or more stages of the needle (60) It is to fix the installation direction.

The adsorbent 20 adsorbs molybdenum (Mo- 99 ) to alumina filled with sodium molybdate in the form of a cancer diagnostic agent composed of sodium pertechnerate (Tc- 99m ) when contacted with a reactant such as NaCl. Allow the injection solution to be generated.

That is, the core component of the adsorbent is available for the base material for adsorbing -99 Mo (molybdenum-99) and its appearance is in the form of a powder with a silica gel modified by the manganese dioxide which is in the form of a powder is a light band of the metallic Alumina [(1) Alumina-neutral: Al 2 O 3 - pH 7.0, (2) Alumina-Basic: Al 2 O 3 - pH 9.0, (3) Alumina-acid: Al 2 O 3- pH 4.0] What is to be filled in each of the glass container, which corresponds to the general technical details, and thus a detailed description thereof will be omitted.

And the filter 30, 30 ', made of a soft (permeable) felt (felt) so that the adsorbent 20 can maintain the filled state in the glass container (10).

The porous support plate 40 is provided in the form of a disk for supporting the lower filter 30 'while the glass composition is combined to have a water permeation function so that the inside of the lower sealing member 30' is provided. An expansion guide groove 58 formed on the side serves to prevent the lower filter 30 'from being pushed out.

The protruding end 54 is made of a diameter larger than the outer diameter of the glass container 10 so as not to be directly hit by the protruding end 54 when the glass container 10 is placed on the bottom surface in the longitudinal direction.

The expandable guide groove 58 forms a needle-shaped center groove 58a inside the center of the inner surface of the sealing member 50, 50 'and the inclined surface 58b from the center groove 58a to the outside of the inner surface tip. It is formed in the shape of being expanded to form a).

This is because the reactant injected by the needle 60 inserted by the upper sealing member 50 is evenly spread in the upper filter 30 through the expansion guide groove 58 to contact the adsorbent 20 via the upper filter 30. Adsorption efficiency of the reactant may be greatly increased, and the injection liquid eluted through the lower filter 30 'may be focused on the needle-shaped central groove 58a to increase the dissolution efficiency.

The needle insertion groove 56 is formed in a straight shape in the circumferential direction from the center of the outer surface of the sealing member 50, 50 'to allow the bent portion 62 of the needle 60 is fitted, but the sealing member 50, 50 ') So that the position of the center portion of the needle 60 can be easily checked so that the tip of the needle 60 can be accurately inserted into the center of the sealing member 50 (50').

When described in detail according to the accompanying drawings an embodiment according to the column for producing a cancer diagnostic agent of the radiopharmaceutical of the present invention as follows.

The column for generating the cancer diagnostic agent according to the present invention is a glass container in a state where upper and lower felt filter filters 30 and 30 'of the adsorbent 20 are filled in powder form in the glass container 10. The sealing member 50, 50 'to the upper and lower portions of the 10 is made as in the usual configuration, but in the present invention, the sealing member 50, 50' is provided with silicon while the locking jaw 52 Protruding end portion 54 provided with a diameter larger than the outer diameter of the glass vessel is formed on the outside to prevent damage by preventing the glass vessel 10 from being directly hit by the protruding end portion 54 when placed on the bottom surface in the longitudinal direction. You can do it.

In addition, in the present invention, since the expandable guide grooves 58 are formed on the inner surfaces of the sealing members 50, 50 ', respectively, the inclined surface 58b of the guide groove 58 injected through the upper sealing member 50 is provided. Reactant is spread widely along the () to evenly contact the adsorbent 20 through the upper filter 30, so that the adsorption efficiency can be greatly increased, the guide groove 58 of the lower sealing member (50 ') is the lower filter (30'). The injection solution eluted through the center is concentrated to the center groove portion 58a along the inclined surface 58b of the guide groove 58, so that elution is easily performed through a needle inserted into the center of the lower sealing member 50 '.

In addition, in the present invention, the needle insertion groove 56 is formed on the outer surface of the upper and lower sealing members 50 'in the form of a straight line in the circumferential direction at the center of the outer surfaces of the sealing members 50, 50'. The bent part 62 of the needle 60 is inserted to maintain the fixed state, so that the needle can be safely and conveniently used, and the position of the center part of the sealing member 50, 50 'can be easily checked to confirm the tip of the needle 60. It can be accurately inserted in the center of the sealing member 50, 50 'to facilitate the injection of the reactant and the elution of the injection solution.

While the present invention has been described with reference to the exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments.

A: column 10: glass container
20: adsorbent 30,30 ': filter
40: porous support plate 50,50 ': sealing member
52: engaging jaw 54: protruding end
56: needle insertion groove 58: guide groove
58a: center groove 58b: inclined surface
60: needle 62: bending part

Claims (5)

Glass container 10 made of a rod-shaped tube and provided with a transparent body,
And the adsorbent 20 is filled in the form of a powder in the glass container 10,
Adhering upper and lower filters 30, 30 'to maintain the shape stability of the adsorbent 20,
A porous support plate 40 having a plurality of through holes formed in close contact with the bottom surface of the lower filter 30 ',
The sealing member 50, 50 'of the upper and lower ends of the glass container 10 are respectively bonded to each other, but larger than the outer diameter of the glass container outside the locking jaw 52 of the sealing member 50, 50'. A protruding end 54 provided with a diameter,
Column for generating a cancer diagnostic agent for radiopharmaceuticals, characterized in that by forming an expansion guide groove 58 in the inner surface of the sealing member (50, 50 ').
The method of claim 1,
The porous support plate 40 is a glass diagnostic of radiopharmaceuticals, characterized in that the combination of glass (Frit glass) is provided in the form of a disk for supporting the lower filter 30 'while having a permeability function Production column.
The method of claim 1,
The expandable guide groove 58 forms a needle-shaped center groove 58a inside the center of the inner surface of the sealing member 50, 50 'and the inclined surface 58b from the center groove 58a to the outside of the inner surface tip. Column for producing a cancer diagnostic agent of a radiopharmaceutical, characterized in that formed in a form that is expanded to form a).
The method of claim 1,
A needle insertion groove 56 is provided on the outer surface of the sealing member 50, 50 ′ to fix the installation direction of the needle 60 by inserting a bent portion 62 of the needle 60 bent in one or more steps. A column for producing a cancer diagnostic agent of a radiopharmaceutical, characterized in that it is possible.
The method of claim 4, wherein
The needle insertion groove 56 is formed in a straight shape in the circumferential direction at the center of the outer surface of the sealing members 50, 50 'to allow the bent portion 62 of the needle 60 to be fitted and the sealing members 50, 50. ') The column for generating cancer diagnostics of radiopharmaceuticals, characterized in that the end of the needle (60) can be plugged into the center.
KR20100126376A 2010-12-10 2010-12-10 The sorption column assembling KR101162459B1 (en)

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KR101162459B1 true KR101162459B1 (en) 2012-07-04

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Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101710157B1 (en) * 2014-07-23 2017-03-02 주식회사 엔바이로코리아 The sorption column of producing both cancer diagnosis matter and cancer treatment matter and the sorption column assembly using thereof
KR101958261B1 (en) * 2018-11-21 2019-03-15 (주) 비앤비 Column for Automated Sequential Radionuclides Separator

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001387A (en) 1973-07-30 1977-01-04 Medi-Physics, Inc. Process for preparing radiopharmaceuticals
US4039835A (en) 1976-03-12 1977-08-02 Colombetti Lelio G Reloadable radioactive generator system
US5695989A (en) 1990-10-18 1997-12-09 Cellpro, Inc. Apparatus and method for separating particles using a pliable vessel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001387A (en) 1973-07-30 1977-01-04 Medi-Physics, Inc. Process for preparing radiopharmaceuticals
US4039835A (en) 1976-03-12 1977-08-02 Colombetti Lelio G Reloadable radioactive generator system
US5695989A (en) 1990-10-18 1997-12-09 Cellpro, Inc. Apparatus and method for separating particles using a pliable vessel

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