KR101160668B1 - A biochip including a light emitting device and a bio diagnosis device and method using thereof - Google Patents
A biochip including a light emitting device and a bio diagnosis device and method using thereof Download PDFInfo
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- KR101160668B1 KR101160668B1 KR1020100063662A KR20100063662A KR101160668B1 KR 101160668 B1 KR101160668 B1 KR 101160668B1 KR 1020100063662 A KR1020100063662 A KR 1020100063662A KR 20100063662 A KR20100063662 A KR 20100063662A KR 101160668 B1 KR101160668 B1 KR 101160668B1
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Abstract
The present invention relates to a biochip, and more particularly, a biolayer in which a biochemical reaction between a reference sample and a target sample occurs and an image sensor layer sensing light emitted from the biolayer are combined into a single chip. It relates to a biochip with a light emitting device.
The present invention has an advantage that the incident light of the light emitting device does not enter the image sensor layer without a separate filter layer by embedding the light emitting device inside the biochip and placing a reflecting plate under the light emitting device.
Description
The present invention relates to a biochip, a biodiagnostic apparatus and a method, and more particularly, to a biochip, a biodiagnostic apparatus and a method incorporating a light emitting device.
In general, a biochip is formed in a form in which a reference sample composed of biological materials such as DNA and protein is regularly arranged on a substrate made of a material such as glass, silicon, metal such as gold, or nylon.
Biochip basically uses the biochemical reaction between the reference sample and the target sample immobilized on the substrate. Representative examples of such biochemical reactions between the reference sample and the target sample include complementary binding between DNA bases and antigen-antibody reactions. .
Diagnosis by biochip is mostly done by detecting the extent to which the biochemical reactions of the reference sample and the target sample occur through optical processes. Generally used optical processes utilize fluorescence or luminescence.
1 is a cross-sectional view of a conventional biochip combined with an image sensor.
Referring to FIG. 1, the
The
In this case, when the light emitting material remains, light is generated from the light emitting material itself, so it is necessary to block external light. However, when the fluorescent material remains, a separate external light is required to emit the fluorescent material. Therefore, in this case, a filter layer is required to block the external light from being incident on the image sensor layer.
The
That is, the external light corresponds to noise when determining whether the fluorescent material is fluorescence through the image sensor layer. Therefore, the filter layer serves to remove noise called external light.
The
However, such a
The technical problem to be solved by the present invention is to provide a biochip and a bio diagnostic apparatus using the same by forming a light emitting device for emitting a fluorescent material inside the biochip and placing a reflector under the light emitting device. have.
Another technical problem to be solved by the present invention is to provide a biochip and a bio diagnostic apparatus using the same so that light generated from a light emitting device or a fluorescent device does not enter the lower image sensor layer.
Another technical problem to be solved by the present invention is to provide a bio-diagnostic method that can properly determine the light generated from the light emitting device or the fluorescent device.
In the biochip including the light emitting device according to the present invention for achieving the above technical problem, a bio layer in which a plurality of reaction regions in which a biochemical reaction between a reference sample and a standard sample occurs is formed in the shape of a groove and a lower portion of the bio layer. And an image sensor layer having a plurality of photo detectors, wherein a light emitting device is included in the bio layer.
According to another aspect of the present invention, there is provided a biodiagnosis apparatus including a biochip having a light emitting device and a signal processor configured to analyze and process a signal output from the biochip.
According to another aspect of the present invention, there is provided a biodiagnostic method comprising: (a) storing first information generated by light emission of a light emitting device before a target sample is added to a reference sample; (b) storing second information generated by light emission of the light emitting device after the target sample is added to the reference sample; And (c) diagnosing the first information by comparing the second information with each other.
The present invention has the advantage that a separate filter layer is not required by forming a light emitting device for emitting a fluorescent material inside the biochip and placing a reflecting plate under the light emitting device.
1 is a cross-sectional view of a conventional biochip combined with an image sensor.
2 is a cross-sectional view of a biochip incorporating a light emitting device according to the present invention.
3 is a block diagram illustrating an embodiment of a bio diagnostic apparatus using a biochip incorporating a light emitting device according to the present invention.
Figure 4 is a block diagram showing another embodiment of a bio diagnostic apparatus using a biochip with a light emitting device according to the present invention.
Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.
2 is a cross-sectional view of a biochip incorporating a light emitting device according to the present invention.
Referring to FIG. 2, a
The
The plurality of
The
The
The
The
The
Although not shown, a filter layer may be added between the
The
The plurality of
3 is a block diagram illustrating an embodiment of a bio diagnostic apparatus using a biochip incorporating a light emitting device according to the present invention.
Referring to FIG. 3, the bio diagnostic apparatus 300 according to the present invention includes a
The
Figure 4 is a block diagram showing another embodiment of a bio diagnostic apparatus using a biochip with a light emitting device according to the present invention.
Referring to FIG. 4, the bio
Since the
The
The
In general, the
The
That is, the electrical signal stored in the
In contrast, the electrical signal stored in the
Therefore, the difference between the electrical signals stored in the
The
As described above with reference to FIG. 3, the signal processor may include an ISP (Image Signal Processor), which is a program capable of analyzing electrical signals, so that a desired diagnosis result may be obtained in a short time.
If necessary, the
Hereinafter, a biodiagnostic method using a biochip incorporating a light emitting device according to the present invention will be described.
According to an exemplary embodiment of the present invention, a biodiagnostic method stores first information generated by light emission of a light emitting device embedded in a biochip before a target sample is added to the reference sample, and after the target sample is added to the reference sample, Storing second information generated by light emission of an embedded light emitting device, and diagnosing the first information by comparing the second information with each other.
Preferably, the storing of the first information and the second information is performed after detecting the light emission from the light emitting element by a plurality of light detectors, wherein the first information and the second information are stored in the plurality of information. It is an electrical signal from a light sensor.
The diagnosing step is preferably performed by a circuit formed on the semiconductor substrate. If necessary, the diagnostic result can be obtained in advance of a signal processing step including an operation function for obtaining more organized information, for example, a function for removing noise.
While the present invention has been described in connection with what is presently considered to be the most practical and preferred embodiment, it is to be understood that the invention is not limited to the disclosed embodiments. It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the scope of the present invention.
Claims (10)
Bio layer having a plurality of reaction zones in the form of grooves in which the biochemical reaction between the reference sample and the standard sample occurs;
Is formed below the bio layer, and includes an image sensor layer is formed a plurality of photo detectors (Photo Detector),
A biochip with a light emitting device, characterized in that the light emitting device is included in the bio layer.
And a reflecting plate formed under the light emitting device and reflecting light emitted from the light emitting device.
Biochip with a light emitting device, characterized in that the LED (Light Emitting Diode).
Biochip with a light emitting device, characterized in that the CCD (Charge Coupled Device) or CMOS (Complementary MOS) image sensor.
And a filter layer positioned between the bio layer and the image sensor layer to block light emitted from the light emitting device.
A biochip incorporating the light emitting element according to any one of claims 1 to 5
And a signal processor for analyzing and processing the signal output from the biochip.
A biochip containing the light emitting device according to any one of claims 1 to 5;
A first storage unit storing a signal output from the biochip before a biochemical reaction between the reference sample and the standard sample occurs;
A second storage unit storing a signal output from the biochip after the biochemical reaction occurs;
A comparison unit comparing the signal stored in the first storage unit with the signal stored in the second storage unit; And
And a signal processor configured to analyze and process the signal output from the comparator.
(a) storing first information generated by light emission of the light emitting device before the target sample is added to the reference sample;
(b) storing second information generated by light emission of the light emitting device after the target sample is added to the reference sample; And
and (c) diagnosing the first information by comparing the second information with each other.
The bio-diagnostic method according to claim 1, wherein the bio-diagnosis method is performed after light emission from the light emitting device is detected by a plurality of light sensors.
A biodiagnosis method, characterized in that it is carried out by a circuit formed on a semiconductor substrate.
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KR1020100063662A KR101160668B1 (en) | 2010-07-02 | 2010-07-02 | A biochip including a light emitting device and a bio diagnosis device and method using thereof |
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KR1020100063662A KR101160668B1 (en) | 2010-07-02 | 2010-07-02 | A biochip including a light emitting device and a bio diagnosis device and method using thereof |
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KR101160668B1 true KR101160668B1 (en) | 2012-06-28 |
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Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101569515B1 (en) | 2014-08-13 | 2015-11-27 | (주)옵토레인 | A biochip including a side- light type light emitting device and a manufacturing method thereof |
EP3001182B1 (en) * | 2014-09-25 | 2017-11-29 | Optolane Technologies Inc. | Method for manufacturing biochip having improved fluorescent signal sensing properties and biochip manufactured by the same |
KR101727301B1 (en) * | 2014-09-25 | 2017-04-14 | (주)옵토레인 | A manufacturing method for biochip improved sensitivity property for fluorescence signal and the biochip manufactured by the same |
KR102625129B1 (en) * | 2018-08-23 | 2024-01-15 | 엘지디스플레이 주식회사 | Wearable photoluminescence sensor and remote sensing apparatus including the same |
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US20050063870A1 (en) * | 2003-09-01 | 2005-03-24 | Seiko Epson Corporation | Biosensor and method of manufacturing biosensor |
KR100801448B1 (en) * | 2007-05-16 | 2008-02-11 | (주)실리콘화일 | Bio chip |
KR20080098855A (en) * | 2007-05-07 | 2008-11-12 | 삼성전자주식회사 | Filterless biosensor using multiple oled light sources |
KR100923461B1 (en) * | 2007-10-31 | 2009-10-27 | 전자부품연구원 | A sample analysis appparatus for a micro-plate |
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Patent Citations (4)
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US20050063870A1 (en) * | 2003-09-01 | 2005-03-24 | Seiko Epson Corporation | Biosensor and method of manufacturing biosensor |
KR20080098855A (en) * | 2007-05-07 | 2008-11-12 | 삼성전자주식회사 | Filterless biosensor using multiple oled light sources |
KR100801448B1 (en) * | 2007-05-16 | 2008-02-11 | (주)실리콘화일 | Bio chip |
KR100923461B1 (en) * | 2007-10-31 | 2009-10-27 | 전자부품연구원 | A sample analysis appparatus for a micro-plate |
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