KR101155967B1 - A health food composition for prevention and treatment of allergic rhinitis containing Germanium, elvan and red ginseng Extracts - Google Patents

Abstract

The present invention relates to a health food composition for the prevention and treatment of allergic rhinitis containing germanium, elvan and red ginseng extract as an active ingredient, and more particularly, a health food composition for the prevention and treatment of allergic rhinitis according to the present invention. Silver purified water, germanium, elvan and red ginseng extract as an active ingredient, more preferably, the purified water, germanium and elvan is preferably formed in a mixture aged at 20 to 30 ℃ for 90 to 150 days The red ginseng extract is mixed with purified water, germanium and elvan, and extracted at 70 to 90 ° C. for 25 to 40 hours using a mixture aged at 20 to 30 ° C. for 90 to 150 days as an extraction solvent. do.

Germanium, Macvanseo, Red Ginseng, Allergic Rhinitis, Health Food

Description

A health food composition for prevention and treatment of allergic rhinitis containing Germanium, elvan and red ginseng Extracts}

The present invention relates to a health food composition for the prevention and treatment of allergic rhinitis containing germanium, elvan and red ginseng extract as an active ingredient, and more particularly, a health food composition for the prevention and treatment of allergic rhinitis according to the present invention. Silver purified water, germanium, elvan and red ginseng extract as an active ingredient, more preferably, the purified water, germanium and elvan is preferably formed in a mixture aged at 20 to 30 ℃ for 90 to 150 days The red ginseng extract is mixed with purified water, germanium and elvan, and extracted at 70 to 90 ° C. for 25 to 40 hours using a mixture aged at 20 to 30 ° C. for 90 to 150 days as an extraction solvent. do.

Recently, rhinitis-related diseases are on the rise, and rhinitis refers to inflammation of the nasal mucosa inside the nose, which is a respiratory organ of the human body, and includes acute, chronic rhinitis, viral rhinitis caused by cold, and allergic rhinitis. .

Among these, allergic rhinitis is a hypersensitivity reaction to the nasal mucosa, which causes allergens (antigens) to be exposed to the nasal mucosa and mediate various types of IgE antibodies, including apoptotic cells and eosinophils. Inflammatory cells are caused by the inflammatory reactions caused by the various mediators secreted by them. It is characterized by three main symptoms: seizure sneezing, clear runny nose, and stuffy nose, and you may suspect allergic rhinitis when you have two or more of these symptoms. In addition to the characteristic symptoms, it may be accompanied by itching around the nose, headache, and olfactory deterioration. Complications may include otitis media, sinusitis, and pharyngitis.

Diseases to distinguish from allergic rhinitis include non-allergic eosinophilic rhinitis, vasomotor rhinitis, and colds. The most common disease among all patients with allergic rhinitis is cold. Even if you catch a cold, you may have symptoms of sneezing, runny nose and stuffy nose, so some people know that they have a common cold, and often take cold medicine at pharmacies. However, most cases of colds improve within 1 week, but allergic rhinitis usually lasts for 1 to 2 months, and if symptoms improve, it is difficult to catch it again within 3 weeks, but allergic rhinitis develops symptoms within 3 weeks even if symptoms improve. It may reappear, and colds are accompanied by mild fever, but allergic rhinitis is not accompanied by fever. Therefore, if there are no fever and frequent cold symptoms, allergic rhinitis should be considered.

On the other hand, allergic rhinitis is classified into intermittent allergic rhinitis that occurs only in a short period of time depending on the duration of symptoms and persistent allergic rhinitis that occurs for a month or more. Classify as mild and moderate severe. It is also divided into seasonality, which occurs only in one particular season, and perennial seizures throughout the year. Seasonal allergic rhinitis is often associated with the season in which pollen is flying, but it is chronic, continues throughout the year, and occurs seasonally regardless of season.

Allergic rhinitis is a typical allergic disease caused by the combination of genetic and environmental factors along with allergic asthma. Allergy refers to hypersensitivity from the normal and no symptoms occur in normal people, but hypersensitivity reactions to allergy sufferers. Representative exacerbations of rhinitis include climate change, cold, air pollution, stress, and allergens that cause allergic rhinitis. House dust mites, pollen, mold, pet hair or dandruff, cockroaches and other insect inhalation is typical, but food, food additives, drugs, etc. may cause allergic rhinitis. It is not clear how many people with allergies are allergic. Avoiding exposure to antigen is particularly meaningful in infants, where sensitization occurs, as children develop symptoms after prolonged exposure to antigens when they have atopic inclinations.

Treatment of allergic rhinitis can cause allergens (antigens) such as house dust mites, pollen, pet hair, insects, and fungi, and tobacco smoke, indoor pollutants, climate change, worsening drugs, and stress. There are environmental therapies (avoidance therapy), drug therapies that use eating or nasal sprays, and immunotherapy that raises immunity at regular intervals. Avoiding allergens is the most important treatment, but fundamentally difficult to avoid, it is difficult to obtain sufficient therapeutic effect with avoidance therapy alone, and it is necessary to control symptoms with proper medication.

However, it is very difficult to complete the treatment with the above therapies, and chemicals such as tranilast and ketotifen, which are mainly used for the treatment of allergic rhinitis, are highly toxic, such as digestive disorders, dizziness, and heartburn. In addition to causing side effects, and in addition to long-term tolerant to cause allergic rhinitis has a problem.

Therefore, there is a need for a health food composition that can prevent or treat allergic rhinitis through food that can be easily and effectively consumed.

The present invention has been made to solve the above problems, the present invention is to prevent and treat allergic rhinitis health food composition for the prevention and treatment of allergic rhinitis containing germanium, ganban stone and red ginseng extract as an active ingredient For the purpose of providing it.

In order to solve the above problems, the present invention may include the following means.

Health food composition for the prevention and treatment of allergic rhinitis according to an embodiment of the present invention, purified water, germanium, elvan, red ginseng extract as an active ingredient.

In the health food composition for preventing and treating allergic rhinitis according to another embodiment of the present invention, purified water is 1000 ~ 2000g, germanium is 50 ~ 100g, ganban stone is 50 ~ 100g, red ginseng extract is formed to 300 ~ 600g It features.

In the health food composition for the prevention and treatment of allergic rhinitis according to another embodiment of the present invention, the red ginseng extract, a mixture of purified water, germanium and elvan, aged at 20 ~ 30 ℃ for 90 days to 150 days It is characterized in that it is extracted at 70 ~ 90 ℃ for 25 to 40 hours using an extraction solvent.

In a health food composition for preventing and treating allergic rhinitis according to another embodiment of the present invention, the purified water, germanium, and elvan are formed in a mixture aged at 20 to 30 ° C. for 90 to 150 days. It is done.

The present invention provides an excellent effect in the prevention and treatment of allergic rhinitis containing germanium, elvan and red ginseng extract as active ingredients in order to prevent and treat allergic rhinitis.

Hereinafter, the present invention will be described in detail.

Health food composition for the prevention and treatment of allergic rhinitis according to the present invention contains purified water, germanium, elvan and red ginseng extract as an active ingredient.

Germanium used in the present invention is an atom of atomic number 32 having 32 electrons, and four electrons are arranged in the outermost orbit, and one electron therein has a property that is very advantageous. If it is advantageous, holes are generated in the outermost orbit, which has the property of attracting other electrons from the outside to block the holes, while the nervous system of the living body is maintained to maintain its normal function by the electrical action occurring in the living body. It is known that the potential of each cell shows a different value in various affected areas in the living body, and germanium used in the present invention may use various germanium, preferably organic germanium extracted from plants such as wild ginseng and ginseng. This is suitable. Dr. Atsugi Katsuko of Japan reduced the germanium oxide extracted from coal to hydrogen to make germanium crystals. Based on this, many studies have succeeded in the first synthesis of organic germanium and amino acid germanium dissolved in water. -132 "and AGO (Aminoacid Germanium Oxide), and the official name of the organic germanium is Bis. P-Carboxyethyl Germanium Sesquioxide (Bis. P-Carboxyethyl Germanium Sesquioxide). On the other hand, the pharmacological action by germanium is not yet fully understood, but due to the electrical properties such as the ion generating effect and the radical scavenging effect of germanium, electron exchange is performed between the affected part and the abnormal potential of the affected part is reduced. It is judged to have normalized blood pressure adjustment, anticancer action, and induced action, and plants containing a lot of germanium include wild ginseng, ginseng, ganoderma lucidum, garlic, comfrey, and aloe.

A rock elvan used in the present invention belong to the quartz porphyry of igneous acids, silica (SiO ₂₎ and aluminum oxide (Al ₂ O ₃₎ migratory minutes, and means oxidation required for the human body and living cells ferric (Fe ₂ O ₃ ) containing about 40 kinds of various mineral elements, and containing 30,000 to 150,000 many voids per cm 3. These elvan stones act to regulate biological growth and physiological function, maintain vitality of cells, and promote growth. These effects of elvan can be easily found in real life. For example, aquariums, fish tanks, and fish farms using elvan have been able to improve water quality with excellent water quality control. Since it consists of more than 30,000 multi-layered porous materials per cm 3, it has a large specific surface area, which uses capillary action to adsorb and decompose heavy metals and contaminants. In addition, since elvan has dissolved about 40 kinds of minerals that give vitality to the human body, it is effective for metabolism and skin health care. All rocks contain minerals, but in the case of elvan It is characterized by eluting not only minerals generally known but also effective minerals which are not explained by modern science. Furthermore, the elvan has abundant oxygen content, and when the elvan is put in water, the chemical oxygen demand (COD) and biological oxygen demand (BOD) are lowered, thereby acting as an antiseptic action and vitalizing the living body, generating far infrared rays, and radiating the resonance. It maintains the freshness of food, improves taste, and promotes blood circulation by absorbing, and far infrared rays emitted by ganbanite penetrate deeply into the skin 40-50mm to activate cells and promote blood circulation, Waste products are discharged outside the body.

Germanium and ganbanite used in the present invention is characterized in that 50 to 100g of germanium per 50 to 2000g of purified water, and 50 to 100g of ganbanite are mixed. Preferably, the germanium and the elvan are mixed with 50 to 100 g of germanium per 50 to 2000 g of purified water and 50 to 100 g of elvan, and aged at 20 to 30 ° C. for 90 days to 150 days using a mixture formed by a known method for allergic rhinitis. It is appropriate to improve the prevention and treatment of the.

Red ginseng (Red Ginseng) used in the present invention is defined according to the ginseng industry law, "not dried ginseng, that is, means steamed and dried by steam or other methods". The main components of red ginseng are glycosides, ginseng fragrances (panacen), polyacetylene-based compounds, nitrogen-containing components, flavonoids, vitamins (group B), trace elements, enzymes, antioxidants, organic acids and amino acids. Is contained, and especially saponin and germanium are contained a lot. Red ginseng has a sedative and arousing effect on the central nervous system, and it acts on the circulatory system to prevent hypertension or atherosclerosis. At the same time, hematopoietic effect (造血 作用) and blood sugar levels (저하) lowers, protects the liver, acts on the endocrine system indirectly effective on sexual behavior and reproductive effects, anti-tumor action (抗)腫 瘍 作用) has a protective effect against radiation, and protects and softens the skin.

On the other hand, the general manufacturing process of red ginseng wash the fresh ginseng or dry ginseng with water, and steamed for a predetermined time depending on the size by using a heated steam in a predetermined container. Dried ginseng is dried by solar heat or other method until 12.5 ~ 13.5% of moisture after primary hot air drying. The fine roots are removed and the shape is refined. It is sorted by size and weight, and vacuum-packed in temper tube.

The red ginseng extract used in the present invention includes not only red ginseng which can be easily purchased as well as extracts extracted from red ginseng by various known methods, but well-known red ginseng extracts can be used, but preferably obtained by the following method. Can be.

First, ginseng such as dried ginseng, rice ginseng, or fresh ginseng is washed with water, and then dried in the shade. Dry ginseng is placed in an extraction container and extracted for a certain period of time at an appropriate temperature in an appropriate amount of extraction solvent. The extract can be filtered and concentrated using a vacuum rotary evaporator or the like.

As the extraction solvent, a polar solvent selected from water (purified water), a lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof may be used. Preferably, in order to maximize allergic rhinitis and treatment, germanium per 1000 to 2000 g of purified water may be used. 50-100 g, elvan is 50-50 g mixed, it is suitable to use the mixture formed by aging by a known method at 20 ~ 30 ℃ for 90 to 150 days.

The amount of the extraction solvent is 2 to 10 times the dry weight of ginseng such as dried ginseng, rice ginseng, or fresh ginseng.

The extraction method may be an extraction method such as hot water extraction, reflux cooling extraction, ultrasonic extraction, etc., and may be extracted once to five times, preferably as an extraction method of hot water extraction.

The extraction temperature is preferably 70 ~ 90 ℃, the extraction time is suitable 25 to 40 hours.

After the extract is obtained, solids are removed using a filter paper, the suspension is centrifuged, and the supernatant can be filtered under reduced pressure.

The filtered extract can be concentrated under reduced pressure at 20 ~ 100 ℃, preferably 50 ~ 70 ℃ with a vacuum rotary concentrator.

In addition, the extract of the present invention includes not only the extract by the above-described extraction solvent, but also the extract that has undergone a conventional purification process. Obtained by various additional purification methods, such as, for example, separation using ultrafiltration membranes having a constant molecular weight cut-off value, separation by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity). The fraction is also included in the extract of the present invention.

Extracts of the present invention may be prepared in powder form by additional processes such as distillation under reduced pressure and freeze drying or spray drying.

Health food composition according to the present invention can be confirmed by the following experimental example to prevent and treat allergic rhinitis by containing purified water and germanium, elvan, red ginseng extract as an active ingredient.

On the other hand, the health food composition for the prevention and treatment of allergic rhinitis according to the present invention is preferably formed of purified water 1000 ~ 2000g, germanium 50 ~ 100g, ganban stone 50 ~ 100g, red ginseng extract 300 ~ 600g, the purified water and germanium More preferably, the elvan is formed into a mixture aged at 20 to 30 ° C. for 90 to 150 days.

In addition, the health food composition according to the present invention can be manufactured and processed into a health functional food in the form of tablets, capsules, powders, granules, liquids, pills and the like for the purpose of the treatment and prevention of allergic rhinitis.

For example, the health food composition in the form of tablets may be prepared as it is or granularly mixed with an excipient, a binder, a disintegrating agent or other additives in a suitable manner, and then compressed into a glidant or the like, or prepared in a tablet form. Prepare functional foods by directly compression molding them as they are, or by mixing them evenly with excipients, binders, disintegrants or other suitable additives, or by negative compression molding the health foods as they are or evenly added with appropriate additives. The excipient, binder or other suitable additives are added to the functional food, and the mixed powder is wetted with a solvent, the wet powder is molded into a mold at low pressure, and then dried and prepared by a suitable method. In addition, the nutraceutical can be added to the health functional food in the form of tablets, if necessary, can be avoided with a suitable epidermis.

Among the health functional foods in the form of capsules, the hard capsules are usually prepared by mixing the capsules evenly with the health functional foods or excipients suitable for the health functional foods, granulated by a suitable method, or granulated with a suitable epidermal agent as it is or Soft capsules are prepared by filling them, and soft capsules are usually filled with capsules containing glycerin or sorbitol in a capsule form containing gelatin or appropriate excipients suitable for health functional foods or health functional foods. It is molded and prepared, and a coloring agent preservative etc. can be added to the said capsule base as needed.

Circular functional foods are usually mixed with excipients, binders, disintegrants, etc., and then molded into a spherical form in a suitable manner, and the coating is carried out with white sugar or other suitable coating agent, or starch, talc or You can also be greeted with a suitable substance.

The health functional food in the form of granules is usually made by mixing the health functional food as it is or by adding excipients, binders, disintegrating agents, etc., evenly and then granulating it in a proper way to make the particles as even as possible. , Mating agent, etc. can be added. For the health functional food in the form of granules, No. 12 (1680 μm), No. 14 (1410 μm) and No. 45 (350 μm) are used for the next particle size test. It should be less than 5.0% and pass through No.45 to less than 15.0% of the total amount.

The term definitions of the excipients, binders, disintegrants, lubricants, copulation agents, flavoring agents, etc. of the present invention are described in documents known in the art and include those having the same or similar functions. , Korean College of Pharmacy, 5th Edition, p33-48, 1989).

Hereinafter, the present invention will be described in more detail with reference to Examples and Experimental Examples. The following Examples and Experimental Examples are only for more specifically describing the present invention, and the scope of the present invention is not limited by them according to the gist of the present invention. It will be obvious to him.

[Example]

50 g of germanium and 50 g of elvan were mixed with 1000 g of purified water to prepare a mixture aged at 25 ° C. for 90 days. After immersing 400 g of the dried ginseng washed thoroughly in the matured mixture and steamed for 30 hours at 85 ℃ to obtain red ginseng (or red ginseng extract). 400 g of the red ginseng obtained was cut into pieces, and 50 g of germanium and 50 g of ganbanite were mixed with 1000 g of purified water, and then immersed in a mixture aged at 25 ° C. for 10 days for 10 hours to obtain a liquid health food composition.

Experimental Example 1 Clinical Effect Experiment on Allergic Rhinitis

Using a health food composition obtained according to the above example, among allergic rhinitis patients showing symptoms of sneezing, nasal obstruction, and nasal juice, which are typical symptoms of allergic rhinitis, 50 men and women of 20 to 50 age groups were randomly tested. It was. Experimental method was to take the health food composition obtained according to the above example 100ml each morning, evening twice a day for a total of four weeks in the experimental group and then checked the results for sneezing, nasal juice, nasal obstruction. In addition, as a control group, 50 men and women of allergic rhinitis patients were given 100ml of tranilast, an oral drug used for allergic rhinitis, twice a day in the morning and evening. The results were then checked for sneezing, nasal juice and nasal obstruction.

The degree of symptoms was based on the same criteria as Table 1 below, and the improvement results are shown in Tables 2 to 4 below.

Asymptomatic +++ + + - Sneezing attack
(Day times) 10 times or more 9 ~ 4 times 3 times or less 0 Non-juice
(Can be runny nose of the day) 10 times or more 9 ~ 4 times 3 times or less 0 Non Lung Color Nasal congestion is very severe and many hours of breathing through the mouth Severe nasal congestion and quite a few breaths during the day No breathing through mouth but stuffy nose none

Improvement rate for sneezing It became very good Got better A little better No change Improvement Experimental group
Composition of the Invention 54% 26% 18% 2% 98% Control
(Trianilast) 10% 14% 56% 20% 80%

According to Table 2, the improvement rate for the sneeze of the experimental group taking the composition of the present invention showed an improvement rate of 98%, especially the improvement rate corresponding to the very good and improved the bar can be confirmed that 80% Health food composition according to the invention was confirmed to have an excellent effect in the treatment of allergic rhinitis.

Improvement rate for nasal juice It became very good Got better A little better No change Improvement Experimental group
(Article of the Invention)
Relics 64% 26% 10% 0% 100% Control
(Tranillas
T) 10% 26% 36% 28% 72%

According to Table 3, the improvement rate for the nasal juice of the experimental group taking the composition of the present invention showed an improvement rate of 100%, especially the improvement rate corresponding to the very good and improved bar 90 can be confirmed that Health food composition according to the invention was confirmed to have an excellent effect in the treatment of allergic rhinitis.

Improvement rate for non occlusion It became very good Got better A little better No change Improvement Experimental group
(Article of the Invention)
Relics 20% 48% 22% 10% 90% Control
(Tranillas
T) 7% 27% 36% 30% 70%

According to the Table 4, the improvement rate for the non-occluded of the experimental group taking the composition of the present invention showed an improvement rate of 90%, especially it can be confirmed that the improvement rate corresponding to 68% is very good and good Health food composition according to the invention was confirmed to have an excellent effect in the treatment of allergic rhinitis.

Claims (4)

delete delete It contains purified water, germanium, elvan, red ginseng extract as active ingredients, The purified water is 1000 ~ 2000g, the germanium is 50 ~ 100g, the elvan is 50 ~ 100g, the red ginseng extract is formed of 300 ~ 600g, The red ginseng extract is dried ginseng, misam or ginseng, Formed by heating to 70 ~ 90 ℃ for 25 to 40 hours using a mixture of purified water 1000 ~ 2000g, germanium, 50 ~ 100g, ganban stone 50 ~ 100g aged at 20 ~ 30 ℃ for 90 to 150 days Health food composition that can improve allergic rhinitis. It contains purified water, germanium, elvan, red ginseng extract as active ingredients, The purified water is 1000 ~ 2000g, the germanium is 50 ~ 100g, the elvan is 50 ~ 100g, the red ginseng extract is formed of 300 ~ 600g, The purified water, the germanium and the elvan are formed into a mixture aged at 20 to 30 ° C. for 90 to 150 days, The red ginseng extract, dried ginseng, rice ginseng or fresh ginseng, Formed by heating to 70 ~ 90 ℃ for 25 to 40 hours using a mixture of purified water 1000 ~ 2000g, germanium, 50 ~ 100g, ganban stone 50 ~ 100g aged at 20 ~ 30 ℃ for 90 to 150 days Health food composition that can improve allergic rhinitis.