KR101117195B1 - Apparatus and Method for measuring skin aging - Google Patents

Abstract

The present invention relates to a device for measuring the skin aging degree, and more particularly, to a two-dimensional distribution pattern for an image of autofluorescence generated by irradiating excitation light to a certain area of skin to measure the degree of aging. The present invention relates to a skin aging degree measuring device and a method for measuring skin aging degree accurately and simply.

The skin aging degree measuring device of the present invention is a device for measuring the skin aging degree, the excitation light source for generating the excitation light irradiated to the skin of a certain area to be measured, and the skin generated by the excitation light irradiated to the skin of the predetermined area A light receiving unit for generating a fluorescence image of the skin by detecting the magnetic fluorescence of the; and a calculation unit for calculating the aging degree of the skin by analyzing the distribution pattern of the fluorescence intensity of the fluorescence image generated by the light receiving unit.

According to the skin aging degree measuring device of the present invention can not only accurately and simply measure the skin aging degree, but also can accurately know the aging degree (photo-aging) due to sunlight to develop a drug for skin beauty and prevention of skin aging. There is an effect that can be performed efficiently.

Skin care, photo aging, photo-aging, skin aging

Description

Apparatus and Method for measuring skin aging

The present invention relates to an apparatus for measuring skin aging degree and a method for measuring skin aging, and more particularly, to accurately and simply measure aging caused by sunlight as well as aging caused by sunlight using skin autofluorescence. The present invention relates to an aging degree measuring device and a measuring method.

Recently, as interest in beauty is increasing and skin care needs are increasing, research on skin is being actively conducted, and accordingly, the need for more scientific treatment of skin is increasing.

Human skin ages like other organs in humans over time (chronological aging). In addition, unlike other organs, the skin is in direct contact with the external environment, which causes aging due to environmental effects. The main environmental factor causing aging of human skin is ultraviolet light from the sun. Skin aging induced by sunlight is accumulated over time like endogenous aging, and there is a variation in the degree of aging for each person.In contrast to endogenous aging, which depends on time, light aging is associated with the degree of exposure to sunlight. Mainly related to skin pigmentation.

Many methods and equipment are being used to assess the degree of aging in humans. It is used. Wrinkle is a clinical standard indicating the degree of skin aging, and the degree of wrinkles indicates the degree of skin light aging, and there is a photographic scale method of grading the wrinkles using a photograph of wrinkles (Larnier C.). Etc. Evaluation of cutaneous photodamage using a photographic scale.Br J Dermatol, 130, 167-173). In this regard, a Korean patent publication discloses skin images with a digital camera, separates the digital images into red, green, and blue, and then selects a blue image where skin defects are observed. It is a method of measuring skin aging by evaluating wrinkles, blemishes, blemishes, dark circles, and pigmentation. The patent showed a correlation between the mean of gradation deviation and the age [Korean Patent Publication No. 10-2008-0060260 (Stephan Sandroine et al., Method and apparatus for measuring skin defects and evaluation of anti-aging efficacy of beauty products) How)).

Unlike the method of measuring skin aging through the skin image acquired through visible light reflected from the skin as in the above publication, the degree of light absorbed by the skin or the fluorescence emitted through the skin's biometric information is absorbed. There is a way to measure. Irradiating UV light on the skin, especially the face with the most sun exposure, can show the extent of skin damage caused by sunlight that is invisible to the naked eye. This is because UV rays react with damaged melanin pigments under the skin's epidermis to determine the degree of pigmentation (http://www.psychology.ecu.edu.au/photoaging/pages/look.html).

On the other hand, there is a method for determining the degree of aging of the skin by measuring the autofluorescence of the skin and by comparing and analyzing the fluorescence intensity ratio of specific wavelengths through the fluorescence spectrum [US Patent US 4,894,547 (D. Leffell. Etc. Optical method and apparatus for detecting and measuring aging, photoaging, dermal deseases and pigmentation in skin. 1990)] Helium Cadmium laser (325 nm) is used as the fluorescence excitation light source. Was measured. Spectral measurements were taken at the site where the skin was exposed to constant light and at the site where it was not exposed, and the average age was 3, 30 and 63 years old. In this patent, the fluorescence intensity ratio of 390 nm and 429 nm is evaluated as a numerical value indicating the degree of aging. To obtain such a value, an excitation light source such as a laser, an optical fiber that transmits the excitation light, and a fluorescent signal are received. The instrument consists of a detector and an optical spectrum analyzer for wavelength analysis.

However, in the past, the degree of skin aging due to external wrinkles could be measured using the reflected light reflected on the skin, but skin aging due to sunlight could not be measured, or skin aging due to ultraviolet rays could not be accurately evaluated. Only the pigmentation of the known only there was a problem that can not measure the degree of aging throughout the skin.

The present invention is to solve the above problems, an object of the present invention is to analyze the distribution pattern of the fluorescence intensity in the fluorescence image for the skin to measure the skin aging degree that can accurately and simply measure the degree of aging throughout the skin An apparatus and a measuring method are provided.

In order to achieve the above object, the skin aging degree measuring device of the present invention is a device for measuring the skin aging degree, the excitation light source for generating excitation light irradiated to the skin of a certain area to be measured, and the irradiation of the skin of the predetermined area Calculation to detect the fluorescence of the skin generated by the excited excitation light to generate a fluorescence image of the skin, and to calculate the degree of aging of the skin by analyzing the distribution pattern of the fluorescence intensity of the fluorescence image generated by the light receiving unit Contains wealth.

In addition, the excitation light source is characterized in that for generating light in the wavelength band of 350nm to 410nm.

In addition, the light receiving unit includes a multi-wavelength detector for detecting magnetic fluorescence in the visible light region.

In addition, the multi-wavelength detector detects the intensity of green, blue, and red fluorescence, and the calculation unit analyzes the distribution pattern based on the intensity of the green fluorescence among the detected fluorescence and calculates the degree of skin aging.

In addition, the calculation unit calculates the ratio of the intensity of the green fluorescence to the intensity of the blue or red fluorescence, and further considers these to calculate the degree of skin aging.

In addition, the intensity of the green, blue and red fluorescence is characterized in that the average value is obtained by using a representative sample similar to the skin fluorescence color as a standard, and normalized using it.

In addition, the light receiving unit further includes a mask in the form of a lattice, and the calculator calculates the degree of skin aging by calculating a distribution pattern of fluorescence intensity in each divided region in the image divided into a lattice form by the mask.

In addition, the distribution pattern in the distribution pattern calculates the difference in fluorescence intensity between each zone divided by the grid to calculate the heterogeneity of the skin to be measured and calculates the skin aging degree using the same.

In addition, the difference in fluorescence intensity between the respective zones is calculated by calculating the difference between any one of the left and right zones adjacent to each zone and any one of the upper and lower zones.

In addition, the skin aging degree measuring method of the present invention to achieve the above object comprises the steps of irradiating the excitation light to the skin of a certain area to be measured; Detecting the magnetic fluorescence emitted from the skin by the excitation light irradiated in the irradiating step; Generating a fluorescence image of the skin to be measured using the sensed magnetic fluorescence information; Calculating skin aging degree by analyzing a distribution pattern of fluorescence intensity of the generated fluorescence image.

In addition, the magnetic fluorescence emitted from the skin in the detection step of the magnetic fluorescence is detected through a multi-wavelength detector.

In addition, the sensing step detects the intensity of the green, blue and red fluorescence through the multi-wavelength detector, and in the calculation step analyzes the distribution pattern based on the intensity of the green fluorescence of the detected fluorescence and thereby the degree of skin aging Calculate

In addition, in the calculating step, the ratio of the intensity of the green fluorescence to the intensity of the blue or red fluorescence is calculated, and these are further taken into consideration to calculate the degree of skin aging.

Further, in the fluorescence image generating step, a grid of image paper divided into grids is generated using a mask in the form of a grid, and in the calculation step, a distribution pattern of fluorescence intensity in each area divided in the grid divided into images is calculated. Calculate the degree of skin aging.

In addition, in the calculating step, the distribution pattern calculates a difference in fluorescence intensity between each zone divided by the grid to calculate heterogeneity of the skin to be measured and calculates skin aging degree using the distribution pattern.

In addition, the difference in fluorescence intensity between the respective zones is calculated by calculating the difference between any one of the left and right zones adjacent to each zone and any one of the upper and lower zones.

The present invention of the above configuration has the effect that can be measured including the degree of aging of the skin to endogenous aging and aging by sunlight.

In addition, by analyzing the two-dimensional distribution pattern of the aging degree of the skin to evaluate the aging degree of the skin there is an effect that can accurately measure the aging degree of the entire skin, not a part.

In addition, by using a multi-wavelength detector there is an effect that can measure the accurate skin aging degree by comprehensively analyzing all the biological information of the skin.

Hereinafter, a skin aging degree measuring apparatus and a measuring method according to the present invention will be described in detail with reference to the accompanying drawings.

1 is a schematic block diagram of a skin aging degree measuring apparatus according to an embodiment of the present invention.

Referring to Figure 1, the skin aging degree measuring apparatus of the present invention is to the skin that is the measurement target for detecting the autofluorescence emitted from the skin in response to the excitation light source 100 for generating excitation light to be irradiated to the skin and the excitation light irradiated It includes a light receiving unit 200 for generating a fluorescent image for and a calculation unit 300 for calculating the skin aging degree by analyzing the distribution pattern of the fluorescence intensity from the generated fluorescence image.

The present invention is a device for measuring the degree of aging of the skin, the aging of the skin includes wrinkles, blemishes, pigmentation, etc. occurring on the surface of the skin, which is caused by the change or damage of various internal components such as collagen, elastin, melanin It is a phenomenon that is expressed outside the skin as it flows. Therefore, in order to accurately determine the current degree of skin aging, it is more accurate to measure changes in the skin and to evaluate the degree of aging. In the present invention, the age of skin aging by detecting and optically analyzing the fluorescence wavelength distribution and fluorescence intensity of endogenous fluorescent materials including collagen together with the change of distribution of light absorbing materials such as melanin according to the degree of aging. The age of photo-aged skin, especially damaged by sunlight, is measured.

The present invention is a method for evaluating the degree of aging by measuring and analyzing the distribution of wavelengths of autofluorescence occurring in the skin two-dimensionally, preferably detect and image fluorescence in the visible region. A multispectral detector was used to set the selection area for the measured fluorescence image, dividing the selection area into a lattice shape, and the intensity of fluorescence generated in each area, especially the intensity of green, blue and red fluorescence, and neighboring areas. Evaluate skin aging by calculating structural patterns for differences in fluorescence intensity.

In the present invention, the fluorescence image of the skin is detected by the photographing method through the multi-wavelength detector 210 in order to measure the degree of aging of the skin, and the distribution pattern of fluorescence intensity, ie, heterogeneity of fluorescence intensity Measure the aging of the skin. As described above, the aging of the skin is classified into endogenous aging and light aging. In the case of light aging, it is not detected by the reflected light of visible light, but may be detected by self-fluorescence after irradiating the excitation light. In addition, since aging of the skin occurs locally rather than uniformly in the entire area, the wavelength distribution at any point cannot accurately measure the aging degree of the skin. In order to accurately measure the degree of aging of the skin, the present invention detects the magnetic fluorescence of the skin using the multi-wavelength detector 210 in a certain region of the skin and calculates the distribution pattern of the generated fluorescence image, that is, heterogeneity, Can be measured accurately. Heterogeneity is more precise, especially in green fluorescence, since it is a self-fluorescence of the components that cause skin aging inside the skin. Therefore, only green fluorescence may be used to measure skin aging.

The excitation light source 100 is light irradiated to the skin to induce self fluorescence of the skin, and the wavelength of the fluorescent excitation light may be selected to be 350-410 nm, and to avoid the harmfulness of visible light, it is preferable to use 405 nm visible light. desirable. As the excitation light source 100, various lamps may be used with an optical filter passing through a narrow wavelength range, and in one embodiment of the present invention, a mercury lamp is used. Alternatively, one or several light emitting diodes may be used as the light source. The fluorescence generated by the excitation light should be larger than the wavelength of the excitation light, because it is generated through reaction with tissue components such as collagen and flavin under the skin. The excitation light irradiated from the excitation light source 100 is irradiated to the skin of a certain area instead of one point of the spot unit, and thus, the overall skin aging degree can be measured substantially, not the estimation of the skin aging degree or the skin aging degree through the one point. have.

The light receiving unit 200 detects the magnetic fluorescence of the skin and generates a fluorescent image of the skin by using the same. In order to detect the generated magnetic fluorescence and generate an image, in the present invention, a shielding filter is installed to detect multiple wavelength bands at once using the multi-wavelength detector 210 and block reflected light of irradiated excitation light in order to increase measurement accuracy. It is desirable to. In addition, the light receiving unit 200 may include an optical configuration such as a lens, an optical fiber, etc. necessary for detecting magnetic fluorescence to generate a fluorescence image of the skin.

In addition, the light receiving unit 200 may further include a lattice-shaped mask in order to more efficiently calculate the degree of aging of the skin, so that the skin of a predetermined area may be divided into a plurality of zones through the lattice. Through this, the calculation unit 300 has an advantage of more efficiently analyzing the distribution pattern of the fluorescence intensity for calculating the aging degree of the skin.

The calculation unit 300 analyzes the distribution pattern of the fluorescence intensity in the generated fluorescence image and calculates the aging degree of the skin. The calculation unit 300 may include a conventional microprocessor and may include a storage device for storing data used for calculation.

Hereinafter, the process of measuring the degree of aging of the skin in the calculation unit 300 will be described in detail with reference to FIGS. 2 to 6. The distribution pattern of fluorescence intensity for measuring the degree of aging of the skin refers to how the respective fluorescences are distributed among the autofluorescences from the skin in the fluorescence image. Calculate the degree of skin aging.

In one embodiment, in order to measure the aging degree of the skin in the skin aging degree measuring apparatus of the present invention, the distribution pattern of fluorescence intensity is analyzed in consideration of the following four factors and the skin aging degree is calculated using the same.

Heterogeneity (H, K _H )

② Green to Blue fluorescence (G / B, K _GB )

③ Green to Red fluorescence (G / R, K _GR )

④ Green fluorescence (G, K _G )

Here, H is a coefficient representing heterogeneity of each part of the skin tissue, and R, G, and B values are intensities of fluorescence detected in each of the R, G B channels of the multi-wavelength detector 210. G / B and G / R represent ratios of the intensity of fluorescence detected in each of the R, G, and B channels of the multi-wavelength detector. K is the correlation coefficient. As described above, the skin is damaged or damaged as collagen, elastin, melanin, etc. in the skin as the aging progresses, the skin gradually becomes non-uniform according to the damage, and in one embodiment of the present invention by analyzing such nonuniformity Measure the aging of the skin. As shown in FIG. 4, it can be seen that the measurement of the present invention is very accurate as the endogenous aging degree calculated in one embodiment of the present invention shows a high correlation with the actual age of the subject.

 In one embodiment of the present invention, the skin aging age coefficient A (aging factor) is calculated by the following Equation 1 based on the four factors that determine the skin aging.

[Equation 1]

A = H _N * k ₁ + G _N * k ₂ + (G / B) _N * k ₃ + (G / R) _N * k ₄

here

H _N -normalized heterogeneity coefficient

Normalized signal on G _N -G channels

(G / B) _N and (G / R) _N -each normalized signal ratio in channel BG and channel RG

k ₁ , k ₂ , k ₃ , k ₄ -Correction factors taking into account the characteristics of skin types and the correlation of parameters measured with age

Normalization of the parameters used to calculate the aging degree of the skin is performed by calculating the ratio of the measured value to the mean value of the representative sampling of the skin similar to that of each of the men and women. To reduce and accurately measure the aging of the skin.

In order to obtain the aging aging factor (A _ch ), the fluorescence can be measured in the armpits or buttocks, and the like is used to evaluate the endogenous aging of the skin. . The skin aging coefficient A obtained from the skin exposed to sunlight is the sum of the effects of endogenous aging A _ch , which represents the degree of aging of the natural skin, and photoaging A _ph , which is caused by light damage. Therefore, the skin aging age coefficient A _ph due to photoaging is obtained by the following formula.

A _ph = A-A _ch

To accurately measure skin aging age, the cheekbone and armpit areas of the eyeball area of the face were selected. This is the first place where the face is continuously affected by sunlight. In this experiment, the face was selected, and the selected area should be sufficiently uniform, and it is preferable that the place where there is no bright spot fluorescence property such as small hair and red fluorescent point. To meet these conditions, the cheekbone area was selected for the eye area of the face. As a second site, a site not exposed to the sun was selected to measure endogenous aging. In the present invention, the axillary site was selected in consideration of the convenience of measurement.

Representative samples similar to the skin fluorescence color were measured by standard fluorescence images, and the fluorescence results measured once were used without the need to always measure. Representative samples are as follows: 1) Differences that can be caused by the inherent characteristics of the equipment itself (brightness of excitation light, degree of irradiation of excitation light, fluorescence signal sensitivity, etc.) when measuring the age of skin aging using different skin aging measuring devices. It is used to compensate for the measurement error that may be caused by the characteristics of the equipment itself by measuring the value of 2) and to normalize the fluorescence signal value of each sample obtained through the equipment.

Fluorescent samples that can be used as representative samples should 1) be similar to the fluorescence spectrum emitted from the skin, especially in the green region, the main wavelength of the skin. 2) Representative samples should be made of the same material that is observed when fluorescence images are observed.

In one embodiment of the present invention, the sample of the actual fluorescent sample was measured by fluorescence images of the light exposure site (the ulnar bone) and the unexposed site (armpit) as described above.

The fluorescence of the standard fluorescence sample and the actual tester was measured, and the age of skin aging was determined by the following method.

Skin fluorescence was measured using a multi-wavelength detector, and the mask was superimposed on the fluorescence image of the measurement site as shown in the figure. As shown in FIG. 2, the selection regions N and M are set as measurement masks, and the fluorescence image is subdivided into selection regions in units of N * M. In this case, as described above, in order to measure skin aging fluorescence, it is preferable to set a region to avoid specific areas such as large spots, scars and acne in order to minimize errors.

First, in order to analyze the distribution pattern of the fluorescence intensity in the fluorescence image, first, the fluorescence signal of the selected fluorescence standard fluorescence standard is stored using the skin diagnostic equipment, and red (R), green (G), The average value of each of the blue (B) signals is calculated.

: 표준 형광 시료의 형광 영상의 적색 신호 평균값 -

: Red signal average value of fluorescent image of standard fluorescent sample

: 표준 형광 시료의 형광 영상의 녹색 신호 평균값 -

: Mean green value of fluorescence image of standard fluorescence sample

: 표준 형광 시료의 형광 영상의 청색 신호 평균값 -

: Mean blue value of fluorescence image of standard fluorescent sample

The average value of each of the red (R), green (G), and blue (B) signals can be obtained by the following equation.

,

는 마스크가 선택한 영역 안에서 열과 횡의 구역 숫자이며, 그리고

는 형광 표준 시료에서 각 구역에 대해 적색

, 녹색

, 청색

수치를 구하는 식이다. 앞서 설명한 바와 같이 표준 형광 시료는 장비의 영향을 배제시키게 한다.here

,

Is the number of columns and columns within the selected area of the mask, and

Is red for each zone in the fluorescence standard sample.

, green

, blue

The value is calculated. As described above, the standard fluorescent sample allows the effect of the instrument to be excluded.

 Secondly, the skin fluorescence of the subject is measured using the skin diagnosis apparatus for the light exposure area and the non-light exposure area, and the average value is calculated as in the standard fluorescence sample.

: 샘플 형광 영상의 적색 신호 평균값 -

: Average of red signal of sample fluorescence image

: 샘플 형광 영상의 녹색 신호 평균값 -

: Mean green value of sample fluorescence image

: 샘플 형광 영상의 청색 신호 평균값 -

: Mean blue value of sample fluorescence image

  -i: light exposure area

  ni: unexposed areas

,

,

값과 표준 형광 시료(standard) 영상에서의 값의 비를 아래와 같이 구한다. 이는 앞서 설명한 바와 같이 개인 간의 편차를 줄이고 피부 노화도를 정확하게 측정하기 위함이다.After that, it is calculated from the sample image of the subject.

,

,

The ratio between the value and the value in the standard fluorescence sample is obtained as follows. This is to accurately measure skin aging and to reduce the deviation between individuals as described above.

,

,

,

,

및

비값은 다음과 같이 계산한다.

And

The ratio is calculated as follows.

,

,

을 계산한다. 이때 적색(R), 녹색(G), 청색(B) 채널에 대해서 각자 계산할 수 있지만, 실험을 통해 녹색 신호 채널만으로도 피부의 이질성을 충분히 파악할 수 있으므로 도 3a와 도 3b와 같이 실제 영상에서 녹색 신호만 추출하여 나타내었다. Third, the heterogeneity coefficient H (Heterogenity coefficient) of the skin is obtained. The selection area (N, M) is set in the mask and the signal average value of each subdivided unit,

. In this case, the red (R), green (G), and blue (B) channels can be calculated separately, but the green signal channel alone can sufficiently determine the heterogeneity of the skin through experiments, so the green signal in the actual image as shown in FIGS. 3A and 3B Only extracted.

In order to measure the heterogeneity of the fluorescence image, the difference in the fluorescence intensity from each reference unit to the surrounding region should be taken into account, and the difference between the upper, lower, left, and right regions for each reference region may be calculated, but the left side is scanned while scanning each region. The sequential sum of the difference in fluorescence intensity with the zone and the area with the lower zone can be used to calculate the heterogeneity coefficient H that reflects the difference between all zones and represents part of the distribution pattern of fluorescence intensity.

In order to measure the heterogeneity of the fluorescence image, the difference in fluorescence intensity from each reference unit to the surrounding region should be taken into account, and for each reference region, the sum of the difference in fluorescence intensity from the left region and the difference from the lower region should be taken into account. Obtained sequentially, the heterogeneity coefficient H can be calculated.

Where K is the scale coefficient.

In order to improve the accuracy of skin aging calculations, statistical techniques are applied to the database and record the measured data of all subjects, and the average of the exposed and unexposed areas of the recorded database is calculated.

-Average signal of the green channel:

에서의 이질성 계수 :

-

Heterogeneity coefficient at:

-Average value of the green to blue channel:

Average value of the green to red channel:

Using the above average value, the heterogeneity coefficient, green signal value, ratio of green to blue and green to red of the measured object are normalized as follows.

,

,

와

와 측정대상자의 실제나이를 고려한 보정계수

,

,

,

를 구한다.In addition, obtained by the fluorescence signal measured using a correlation such as covariance

,

,

Wow

And correction factors taking into account the actual age of the subject

,

,

,

.

를 구한다.

는 얼굴의 광대뼈 부근에서 획득된 형광 영상의 값들로부터 얻어지며 본래의 내인성 노화와 광노화 현상이 중첩적으로 일어난 피부의 노화도이다. 즉,

Substitute the value obtained above in [Equation 1]

.

Is the degree of aging of the skin, which is obtained from the values of fluorescence images obtained near the cheekbones of the face and in which the intrinsic endogenous aging and photoaging occur. In other words,

(A_ch)는 광의 노출이 되지 않은 내인성 노화의 정도를 나타내는 값으로 실제 생체 피부나이의 특징을 갖는다. 따라서 태양광에 노출된 피부 부위, 예로 얼굴 부위에서의 광노화 영향에 따른 광노화 정도는 다음과 같은 식을 통해 구할 수 있다.

(A _ch ) is a value representing the degree of endogenous aging that is not exposed to light and has the characteristics of an actual skin age. Therefore, the degree of photoaging due to the photoaging effect on the skin part exposed to sunlight, for example, the face part, can be obtained by the following equation.

A _ph = A _{( ch + ph )} -A _ch

4 to 6 will be described below with respect to the accuracy of the skin aging degree according to the present invention.

The data in FIGS. 4-6 measured the skin aging degree for the female group according to the present invention, and the evaluation group was for all 35 women aged 13-93 with phototype II and III of the skin. Measured. Fluorescence from the skin was detected from the multiwavelength fluorescence detector EcoSkin equipped with a special program called Matrix. The fluorescent excitation light is 405 nm. Data processing of the acquired fluorescence signal was performed with an Excel program, and the measurement results are shown from the graph of FIG.

As shown in FIG. 4, the skin aging age coefficient A _ch has the highest correlation with the actual age of the experimenters (correlation coefficient r = 0.93). The correlation is expected to be large because the skin aging age is not affected by external sunlight and is influenced by the biological aging of humans. Actually, as the correlation coefficient, r = 0.93, Aging calculations show that the calculations are quite reliable in indicating skin age. On the other hand, the correlation coefficient of A _{( ch + ph )} is lowered as predicted by r = 0.77. In the case of A _ph , the skin aging is affected by the exposure of sunlight, which is an external factor. It can be seen that there is no association. Therefore, the correlation coefficient shows a very small value of r = -0.05.

7 is a flowchart illustrating a method for measuring skin aging degree according to an embodiment of the present invention. Parts overlapping with the above-described skin aging measuring device will be omitted.

The skin aging degree measuring method of the present invention first irradiates the excitation light generated by the excitation light source 100 to the skin of a certain area to be measured. (S100) Self-fluorescence emitted from the skin by the excitation light irradiated in the irradiation step. The multi-wavelength detector 210 detects (S110) and generates a fluorescence image of the skin to be measured using the detected self-fluorescence information. (S120) The calculation unit 300 is the fluorescence intensity of the generated fluorescence image The skin aging degree is calculated by analyzing the distribution pattern of (S130).

1 is a schematic block diagram of a skin aging degree measuring apparatus according to an embodiment of the present invention,

2 illustrates a fluorescence image of a measurement object generated by the light receiving unit according to the present invention.

FIG. 3a is an image obtained by extracting only a green signal from the generated fluorescence image, and 3b is an image obtained by reconstructing the average value of each zone in the image of 3a,

4 is a graph showing the correlation between endogenous aging and the actual age calculated by the present invention,

5 is a graph showing the correlation between the skin aging degree and the actual age calculated by the present invention,

6 is a graph showing the correlation between the light aging degree and the actual age calculated by the present invention,

7 is a flowchart illustrating a method for measuring skin aging degree according to an embodiment of the present invention.

<Explanation of symbols for the main parts of the drawings>

Excitation light source: 100 Light receiving unit: 200

Multi-wavelength Detector: 210 Calculator: 300

Claims (16)

In the device for measuring the degree of skin aging, An excitation light source for generating excitation light irradiated to a skin of a certain area to be measured; A light receiving unit configured to generate a fluorescence image of the skin by detecting magnetic fluorescence of the skin generated by excitation light irradiated to the skin of the predetermined area; It is made to include a calculation unit for calculating the aging degree of the skin by analyzing the distribution pattern of the fluorescence intensity of the fluorescence image generated by the light receiving unit, The light receiving unit further includes a mask in the form of a lattice, And the calculating unit calculates skin aging degree by calculating a distribution pattern of fluorescence intensities in the divided regions in the image divided into a lattice form by the mask. In claim 1, The excitation light source is a skin aging measuring device, characterized in that for generating light in the wavelength range of 350nm to 410nm. In claim 1, The light receiving unit is a skin aging measuring device, characterized in that it comprises a multi-wavelength detector for detecting the magnetic fluorescence in the visible light region. In claim 3, The multi-wavelength detector detects the intensity of green, blue and red fluorescence, The calculation unit skin aging degree measuring device, characterized in that for analyzing the distribution pattern based on the intensity of the green fluorescence of the detected fluorescence and calculates the skin aging degree. In claim 4, The calculating unit calculates the ratio of the intensity of the green fluorescence to the intensity of the blue or red fluorescence, skin aging degree measuring apparatus, characterized in that to further calculate the skin aging degree. In claim 5, The intensity of the green, blue and red fluorescence is a skin aging degree measuring device, characterized in that the average value is obtained by using a representative sample similar to the skin fluorescence color as a standard, and normalized using it. delete In claim 1, The distribution pattern in the calculation unit calculates the difference in the fluorescence intensity between each zone divided by the grating to calculate the heterogeneity of the skin to be measured and calculates the skin aging degree using the same . In claim 8, The difference in fluorescence intensity between the respective zones is calculated by calculating the difference between any one of the upper, lower and any one of the left, right zones adjacent to each zone. In the method of measuring the skin aging degree, Irradiating the excitation light to the skin of a predetermined area to be measured; Detecting the magnetic fluorescence emitted from the skin by the excitation light irradiated in the irradiating step; Generating a fluorescence image of the skin to be measured using the sensed magnetic fluorescence information; Comprising a step of calculating the skin aging degree by analyzing the distribution pattern of the fluorescence intensity of the generated fluorescence image, In the fluorescence image generating step, the image paper divided into a lattice shape is generated using a lattice-shaped mask, In the calculating step, the skin aging degree measurement method, characterized in that to calculate the degree of skin aging by calculating the distribution pattern of the fluorescence intensity in each divided region in the grid-shaped image. In claim 10, The method for measuring skin aging, characterized in that the magnetic fluorescence emitted from the skin in the step of detecting the magnetic fluorescence is detected through a multi-wavelength detector. In claim 11, Detecting the intensity of green, blue and red fluorescence through the multi-wavelength detector in the sensing step, The method of measuring skin aging, characterized in that for analyzing the distribution pattern based on the intensity of the green fluorescence of the detected fluorescence in the calculation step and calculates the skin aging degree. In claim 12, In the calculating step, the ratio of the intensity of the green fluorescence to the intensity of the blue or red fluorescence is calculated, and the skin aging degree measuring method, characterized in that additionally considering the skin aging degree. delete In claim 10, In the calculating step, the distribution pattern calculates a difference in fluorescence intensity between each zone divided by the grid to calculate heterogeneity of the skin to be measured, and calculates the skin aging degree using the same. . In claim 15, The difference in fluorescence intensity between the respective zones is calculated by calculating the difference between any one of the left and right zones adjacent to each zone and any one of the upper and lower zones.

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