KR101097238B1 - Patch for measuring blood sugar level and Apparatus of the same - Google Patents

Abstract

Blood glucose measurement patch according to the present invention contains an enzyme that reacts with glucose to generate ions, a pair of ion-conducting medium having a fixed groove formed on the outer circumferential surface, a frame formed with a pair of through-holes each receiving the ion-conducting medium A fixing protrusion configured to correspond to the shape of the fixing groove on the inner wall of the through hole to support the ion conductive medium, a substrate stacked on the frame, and formed to be electrically connected to the ion conductive medium on the substrate. It is easy to include an extraction electrode for extracting glucose, and a working electrode, a reference electrode, and a counter electrode, which are formed to be electrically connected to the ion-conducting medium on the substrate, and measure a current generated by the reaction of the extracted glucose with the enzyme. Ion Conductive Media for the Frame It can be replaced.

Blood sugar, ion-conducting media, frames, substrates, electrodes, osmotic pressure, blood collection

Description

Patch for measuring blood sugar level and blood glucose measurement device using the same {Patch for measuring blood sugar level and Apparatus of the same}

The present invention relates to a blood glucose measurement patch and a blood glucose measurement apparatus using the same, and more particularly, to a blood glucose measurement patch and a blood glucose measurement apparatus using the same, which can be easily and reliably installed and can be replaced at the same time. will be.

In order to build a u-Health system, a portable device capable of continuously measuring bio signals must be developed. To this end, the most preferable method is to use a wearable (signalable) biosignal measuring device that can be worn casually for a long time in everyday life because it has an integrated form on clothing.

In the field of wearable systems for monitoring biosignals, applications using biosignals have been continuously studied. For example, MIT professor Michael Holly is wearing a shirt with a variety of sensors sewn to Everest climbers and conducting an experiment in which a specialist examines various body information transmitted wirelessly and informs them. The wearable system has a good condition for continuously measuring an individual's biosignal by the user directly wearing it, but it is difficult to extract the correct data because the biosignal data is different according to heat, user's movement, pressure change during wearing, and measurement body part. Have

Currently, wearable systems for biosignal monitoring are mainly marketed for heart rate monitoring devices, and detailed markets are divided into biosignal monitoring, weight management, exercise evaluation, and health and safety monitoring.

In Korea, research on portable biosignal measurement and systems has been actively conducted in the fields of information and communication, sensor design, signal analysis, etc., but research on how to integrate these studies with clothing is insufficient. In addition, the research on biosignal measuring garments mainly focuses on the usability of garments with biosignal functions for military use and entertainment, or the attaching and detaching and storage methods of measuring instruments. There is insufficient research to develop measuring clothing and accessories.

The present invention is to provide a blood glucose measurement patch and a blood glucose measurement apparatus using the same, which can be easily replaced and can be reliably installed and can be peeled off at the same time.

Technical problems to be achieved by the present invention are not limited to the above-mentioned technical problems, and other technical problems not mentioned above will be clearly understood by those skilled in the art from the following description. Could be.

In order to achieve the above object, the blood glucose measurement patch according to the present invention contains an enzyme that reacts with glucose to generate ions, and a pair of ion-conducting mediators having fixed grooves formed on an outer circumferential surface thereof, as long as the ion-conducting mediators are accommodated, respectively. A frame formed with a pair of through holes, a fixing protrusion formed on an inner wall of the through hole corresponding to the shape of the fixing groove to support the ion conductive medium, a substrate stacked on the frame, and electrically connected to the ion conductive medium on the substrate. An extraction electrode formed to be connected to extract the glucose from the skin, and a working electrode to measure an electric current generated by the reaction of the glucose and the enzyme, which is formed to be electrically connected to the ion conductive medium on the substrate, and a reference electrode And a counter electrode.

In this case, the fixing groove inner surface and the fixing protrusion surface may be curved.

In addition, the blood glucose measurement patch according to the present invention contains an enzyme that reacts with glucose to generate ions, and an open side is inserted to accommodate a pair of ion-conducting mediators, the ion-conducting mediators each having a fixed groove formed on its outer circumferential surface, respectively. A main frame having a hole formed on the inner wall of the insertion hole so as to correspond to a shape of the fixing groove, a fixing protrusion supporting the ion conductive medium, a substrate stacked on the frame, and an electrical connection with the ion conductive medium on the substrate; A working electrode, a reference electrode, and a relative electrode, which are formed to extract the glucose from the skin, and which measure the current generated by the reaction between the extracted glucose and the enzyme, which are formed to be electrically connected to the substrate and the ion conductive medium. It may include an electrode.

In this case, the cover frame may further include a cover frame coupled to an open side of the insertion hole formed in the main frame. Here, the insertion portion that is inserted into the insertion hole in the cover frame may have a shape corresponding to the outer peripheral surface of the ion conductive medium. In addition, an insertion groove corresponding to the fixing protrusion may be formed on a side of the insertion portion.

In addition, the blood glucose measurement patch according to the present invention contains an enzyme that reacts with glucose to generate ions, a pair of ion-conducting mediators having fixed protrusions formed on an outer circumferential surface thereof, and an insertion hole having one side open to receive the ion-conductive mediator, respectively. The main frame is formed, the inner wall of the insertion hole is formed so as to correspond to the shape of the fixing projections for supporting the ion conductive medium, a substrate stacked on the frame, is formed to be electrically connected to the ion conductive medium on the substrate A working electrode, a reference electrode, and a relative electrode, which are formed to be electrically connected to the extraction electrode and the substrate to electrically extract the glucose from the skin, and measure the current generated by the reaction of the extracted glucose with the enzyme. It may include an electrode.

In this case, the cover frame may further include a cover frame coupled to an open side of the insertion hole formed in the main frame. Here, the insertion portion that is inserted into the insertion hole in the cover frame may have a shape corresponding to the outer peripheral surface of the ion conductive medium. In addition, an insertion protrusion corresponding to the fixing groove may be formed at a side of the insertion portion.

In this case, the working electrode applies a voltage for measuring a current generated by the reaction between the ion conductive medium and the extracted glucose, and the reference electrode is reacted by the reaction between the ion conductive medium and the extracted glucose. It becomes a reference potential when measuring the generated current, the counter electrode can measure the current generated by the reaction of the ion conductive medium and the extracted glucose.

On the other hand, the blood glucose measurement apparatus according to the present invention may include a blood sugar measurement patch described above, a control unit for converting the current measured by the counter electrode to a blood sugar value and a display unit for displaying the blood sugar value output from the control unit.

As described above, the blood glucose measurement patch and the blood glucose measurement apparatus using the same according to the present invention form a fixed groove or a fixing protrusion which can fix the separate ion conductive medium to the frame, thereby preventing the separation of the ion conductive medium. Resources such as film are unnecessary.

Thereby, peeling is possible and easy use is attained.

Hereinafter, a blood glucose measurement patch and a blood glucose measurement apparatus using the same will be described in more detail with reference to the accompanying drawings.

1 is a schematic diagram showing a blood glucose measurement patch related to the present invention.

The blood glucose measurement patch 100 shown in FIG. 1 contains an enzyme that reacts with glucose to generate ions, and a pair of ion conductive media 110 having a fixed groove 111 formed on an outer circumferential surface thereof, respectively, The frame 150 having a pair of through holes 151 accommodated therein, a fixing protrusion 153 formed on the inner wall of the through hole to correspond to the shape of the fixing groove, and stacked on the frame. A substrate 130, an extraction electrode 130 formed to be electrically connected to the ion conductive medium on the substrate to extract the glucose from the skin, and the glucose extracted to be electrically connected to the ion conductive medium on the substrate And a working electrode 133, a reference electrode 135, and a counter electrode 137 for measuring a current generated by the reaction of the enzyme.

The ion conductive medium 110 contains an enzyme that generates ions by reacting with glucose.

Conventional blood glucose meters collect blood by using a needle to cut blood from a finger, and measure the blood glucose level by absorbing blood into a sensor site where an enzyme is fixed to an electrode surface using a polymer. These blood glucose meters have considerable pain and fear of blood collection. In particular, diabetics who require periodic blood glucose measurement may avoid the use of blood glucose meters due to their significant discomfort. In addition, since the blood glucose may be momentarily high, the measurer may be in a dangerous state, and thus, continuous monitoring of blood glucose level is often necessary. However, the conventional blood glucose measurement method has a disadvantage in that continuous monitoring is difficult.

In view of these problems, various methods for measuring the concentration of analytes in blood without blood collection have been developed.

For example, the blood glucose measurement means in the form of a patch may be provided on the back of the watch in contact with the skin on the wrist.

When the operator places the device on the wrist, the back of the patch contacts the operator's skin. When the device applies a current to the patch, glucose is extracted from the skin of the measurer to the patch by electroosmotic pressure. The extracted glucose causes an electrochemical reaction with the hydrophilic gel provided in the patch, thus generating a current. The device monitors blood glucose levels by measuring the current generated.

Hydrophilic gels correspond to the enzymes of the ion conducting mediator. Such ion-conducting media should be replaced after one or a certain number of times to ensure reliable blood glucose measurement.

Therefore, as shown in FIG. 6, the blood glucose measurement patch has a structure capable of replacing the ion conductive medium 11. For replacement, the substrate 13, the frame 15, and the film 19 are separated, and then the ion conductive medium 11 inserted into the frame is removed, and then a new ion conductive medium is inserted. After insertion, the board, frame and film are bonded again. The ion conductive medium inserted into the through hole of the frame cannot be separated by the substrate, but can be separated from the opposite side of the substrate. Since the ion conductive medium must be in contact with the skin of the operator, a separate cover cannot be used. Therefore, in order to prevent separation of the ion conductive medium, the film is covered with a film having a second through hole having a width ⓑ smaller than the width ⓐ of the ionically conductive medium.

In such a case, since a separate film must be added, it is difficult to assemble and a phenomenon in which the ion-conducting medium which is free to flow in the through hole formed in the frame is released. This may lower the reliability of the device to the user and may result in rejection of blood glucose measurements. Accordingly, a method of replacing the entire blood glucose measurement patch is proposed, but this causes an increase in maintenance cost.

In order to solve this problem, the ion conductive medium 110 of the blood glucose measurement patch of FIG. 1 has a fixing groove 111 formed on an outer circumferential surface thereof. That is, the ion conductive medium is prevented from being separated from the frame 150 through the fixing grooves, which requires an element facing the fixing grooves.

Accordingly, in the frame in which the pair of through holes 151 into which the ion conductive medium is inserted, the fixing protrusion 153 corresponding to the shape of the fixing groove is formed on the inner wall of the through hole.

Accordingly, as shown in FIG. 2, the fixing groove 111 of the ion conductive medium 110 and the fixing protrusion 153 of the frame 150 mesh with each other to reliably fix the ion conductive medium to the through hole of the frame. In addition, it does not require a separate film for the separation of the ion conductive medium is advantageous to the exfoliation. However, when the ion conductive medium is inserted into the through hole of the frame, the fixing protrusion may interfere with the assembly, so the protrusion of the fixing protrusion should be determined to the extent that the measuring instrument or the patch manager can be inserted by the predictable pressure.

In addition, the inner surface of the fixing groove and the surface of the fixing protrusion may be curved as shown in FIG. 2 so that the ion conductive medium can be easily attached to the through hole.

The substrate 130 is stacked on the frame in which the ion conductive medium is inserted. The substrate is formed with an electrode connected to the outside. An extraction electrode 131 which is formed to be electrically connected to an ion conductive medium and extracts the glucose from the skin, and a working electrode which applies a voltage for measuring a current generated by the reaction between the ion conductive medium and the extracted glucose; 133), the reference electrode 135, which becomes a reference potential when measuring the current generated by the reaction between the ion conductive medium and the extracted glucose, the current generated by the reaction between the ion conductive medium and the extracted glucose The counter electrode 137 measures. The surface in contact with the ion conductive medium opposite to the above electrode follows a general configuration. On the other hand, it is recalled that the number and position of the electrodes can be variously changed.

According to the blood glucose measurement patch described above, the ion conductive medium can be easily inserted into the through hole of the frame. In addition, reliable fixation can be expected after insertion. However, when removing the inserted ion conductive medium, it is necessary to separate the substrate. Such separation of the substrate may damage the terminal formed on the contact surface of the ion conductive medium, and it is difficult to maintain due to the separation and assembly of the substrate. May suffer.

Therefore, the blood glucose measurement patch which can be easily detached from the ion conductive medium without separating the substrate into the frame will be described.

Figure 3 is a schematic diagram showing another embodiment of a blood glucose measurement patch associated with the present invention.

The blood glucose measurement patch 200 shown in FIG. 3 contains an enzyme that reacts with glucose to generate ions, and a pair of ion conductive media 210 having a fixed groove 211 formed on an outer circumferential surface thereof, and the ion conductive media respectively. A main frame 250 having an insertion hole 251 open at one side thereof to be accommodated, a fixing protrusion 253 formed to correspond to the shape of the fixing groove on an inner wall of the insertion hole to support the ion conductive medium, and to the frame A substrate 230 to be stacked, an extraction electrode 231 formed to be electrically connected to the ion conductive medium on the substrate, and extracting the glucose from the skin, and formed and extracted to be electrically connected to the ion conductive medium on the substrate And a working electrode 233, a reference electrode 235, and a counter electrode 237 for measuring a current generated by the reaction of the glucose with the enzyme. Can be.

In the main frame 250 illustrated in FIG. 3, an insertion hole 251 having one side open is formed. The insertion hole 251 is the same as the shape of the ion conductive medium so that the ion conductive medium is accommodated, but one side of the insertion hole 251 is opened so that the insertion hole 251 is inserted in the side portion of the main frame. Accordingly, the ion conductive medium is inserted into the opening of the insertion hole. In this case, the fixing groove 211 formed on the outer circumferential surface of the ion conductive medium and the fixing protrusion 253 formed on the inner wall of the insertion hole serve as a guide when the ion conductive medium is inserted and at the same time, the ion conductive medium is fixed to the main frame after the insertion is completed. It plays a role. In this case, the size and shape of the fixing groove and the fixing protrusion may be variously applied. As in the embodiment of Fig. 1, the size and shape of the fixing grooves and the fixing protrusions are more free because the upper and lower parts are pushed in accordance with the fixing grooves and the fixing protrusions instead of the structure to be inserted and overcome the protrusions of the fixing protrusions by pressure. will be.

The other elements are the same as in the embodiment of FIG.

According to the above, since the ion conductive medium can be inserted into the side of the main frame, the detachment of the ion conductive medium can be performed without separating the substrate and the main frame. Thus, the user (measurer or device manager) can easily replace only the ion-conducting medium without having to replace the entire patch. Furthermore, as in the embodiment of Figure 1 it does not require a separate film for the separation of the ion conductive medium is advantageous in the peeling.

However, in such a case, the ion conductive medium may be undesirably released due to wear of the fixing grooves and the fixing protrusions, or the site to be in contact with various electrodes formed on the substrate may be changed by flow due to prolonged use.

Accordingly, a separate cover frame 270 may be added to ensure that the ion conductive media is reliably fixed in the mounting position.

The cover frame 270 is an element that is coupled to the open side of the insertion hole formed in the main frame and is an element for preventing the ion conductive medium from being separated. Thus, after the ion conductive medium is inserted, it is bonded to the main frame.

The insertion parts 271 and 273 inserted into the insertion hole 251 in the cover frame may have a shape corresponding to the outer circumferential surface of the ion conductive medium. Of course, various shapes are possible, but the phenomenon corresponding to the outer circumferential surface of the ion conductive medium is advantageous for fixing the ion conductive medium. In FIG. 3, since the outer circumferential surface of the ion conductive medium is circular, the shape of the insertion part is also formed in a concave shape.

Since the insertion part is also inserted into the insertion hole 251 of the main frame in which the fixing protrusion is formed, insertion grooves 272 and 274 corresponding to the fixing protrusion may be formed on the side surface.

In some cases, locking means (not shown) may be added to prevent unwanted detachment of the insert.

Figure 4 is a schematic diagram showing a blood glucose measurement patch according to another embodiment related to the present invention.

The blood glucose measurement patch 300 illustrated in FIG. 4 contains an enzyme that reacts with glucose to generate ions, and a pair of ion conductive media 310 having a fixing protrusion 311 formed on an outer circumferential surface thereof, and the ion conductive media, respectively. A main frame 350 having an insertion hole 351 open at one side thereof to be accommodated, a fixing groove 353 formed to correspond to the shape of the fixing protrusion on an inner wall of the insertion hole to support the ion conductive medium, and to the frame A substrate 330 to be stacked, an extraction electrode 331 formed to be electrically connected to the ion conductive medium on the substrate, and extracting the glucose from the skin, and formed to be electrically connected to the ion conductive medium to the substrate It includes a working electrode 333, a reference electrode 335 and a counter electrode 337 for measuring the current generated by the reaction of the glucose with the enzyme. Can.

Unlike the embodiment of FIG. 3, the fixing protrusion 311 is formed on the outer circumferential surface of the ion conductive medium 310 and the fixing groove 353 corresponding to the fixing protrusion is formed in the insertion hole of the main frame. Same as the embodiment of.

The cover frame 370 may further include a cover frame 370 coupled to an open side of the insertion hole formed in the main frame. In this case, the insertion parts 371 and 373 may be inserted into the insertion hole in the cover frame. It may have a shape corresponding to the outer circumferential surface of the conductive medium.

In addition, insertion protrusions 372 and 374 corresponding to the fixing grooves 353 may be formed at side surfaces of the insertion portion.

The blood glucose measurement patch described above can measure blood glucose by extracting glucose without using blood collection using infiltration pressure. Furthermore, the replacement of only the ion-conducting medium used for blood glucose measurement can be prevented from increasing the expected maintenance cost when the entire patch is replaced, and can be easily replaced through side insertion. In addition, it does not require a film or the like used to prevent the separation of the ion conductive medium is advantageous for the peeling of the entire patch.

The blood glucose measurement patch configured as described above may provide a blood glucose measurement result to the outside through various electrodes formed on the substrate as shown in FIG. 5. The intensity of power to be supplied from the outside through the electrode is controlled by the controller 400 separately arranged, and the measured current is also converted into the blood sugar value through the controller. The blood sugar value output from the control unit is displayed through the display unit 500.

Considering the clock-type blood sugar device, the patch may be disposed on a portion of the wrist that contacts the skin, and the display may be disposed behind the patch, and the controller may be disposed between the display and the patch.

On the other hand, those skilled in the art will appreciate that the present invention can be implemented in other specific forms without changing the technical spirit or essential features. Therefore, the above-described embodiments are to be understood as illustrative in all respects and not as restrictive. The scope of the present invention is shown by the following claims rather than the detailed description, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be construed as being included in the scope of the present invention. do.

It is applicable to a blood glucose measurement apparatus capable of measuring blood glucose without performing blood collection.

In particular, it is advantageous to a system having only a control unit and a display unit and applying a separate blood glucose measurement patch.

It can also be applied to medical facilities, such as hospitals, where the cost of replacing the entire patch is high.

1 is a schematic representation of a blood glucose measurement patch associated with the present invention.

Figure 2 is a cross-sectional view showing a blood glucose measurement patch associated with the present invention.

Figure 3 is a schematic diagram showing another embodiment of a blood glucose measurement patch associated with the present invention.

Figure 4 is a schematic diagram showing a blood glucose measurement patch according to another embodiment related to the present invention.

5 is a schematic view showing a blood glucose measurement apparatus to which a blood glucose measurement patch according to the present invention is applied.

6 is a schematic representation of a typical blood glucose measurement patch.

Description of the Related Art

110, 210, 310 ... Ion Conductive Media 111, 211, 353 ... Fixed Groove

150 ... frames 250, 350 ... mainframe

153, 253, 311 ... fixing protrusions 130, 230, 330 ... substrate

270, 370 ... Cover frame 272, 274 ... Insert groove

372, 374 ... insertion projections 271, 273, 371, 373 ... insertion

Claims (12)

A pair of ion-conducting mediators containing an enzyme that reacts with glucose to generate ions and has any one of a fixing groove or a fixing protrusion formed on its outer circumferential surface; A main frame having an insertion hole open at one side thereof to accommodate a part of the ion conductive medium, the other one of the fixing grooves or the fixing protrusions being formed on an inner wall contacting the outer circumferential surface to be engaged with the outer circumferential surface of the ion conductive medium; An inner wall coupled to an open side of the insertion hole of the main frame to form an accommodation part corresponding to the shape of the outer circumferential surface of the ion conductive medium together with the insertion hole, and coupled to one side of the insertion hole to form the accommodation part The cover frame is formed on the inner wall of the other one of the fixing groove or the fixing projection to be engaged with the outer peripheral surface of the ion conductive medium; A substrate stacked on at least one of the main frame and the cover frame; An extraction electrode formed on the substrate to be electrically connected to the ion conductive medium to extract the glucose from the skin; And A working electrode, a reference electrode, and a counter electrode formed on the substrate so as to be electrically connected to the ion conductive medium to measure a current generated by the reaction of the extracted glucose with the enzyme; It is configured to include, wherein the pair of ion-conducting medium is coupled to the main frame by the cover frame in a state located in the insertion hole of the main frame the ion-conducting medium is engaged by the fixing projection and the fixing groove Patch for measuring blood glucose, characterized in that the position is fixed. The method of claim 1, The working electrode applies a voltage for measuring a current generated by the reaction between the ion conductive medium and the extracted glucose, The reference electrode is a reference potential when measuring the current generated by the reaction between the ion conductive medium and the extracted glucose, The counter electrode is a blood glucose measurement patch for measuring the current generated by the reaction of the ion conductive medium and the extracted glucose. The blood sugar measurement patch of claim 1; A control unit which converts the current measured by the counter electrode into a blood glucose level; And A display unit which displays a blood sugar level output from the controller; Blood sugar measuring device comprising a. delete delete delete delete delete delete delete delete delete

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