KR101007346B1 - 표적 mrna와 상보적인 염기서열을 가지는 sirna를 이용하여표적 mrna의 발현을 억제하는 방법 - Google Patents

표적 mrna와 상보적인 염기서열을 가지는 sirna를 이용하여표적 mrna의 발현을 억제하는 방법 Download PDF

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KR101007346B1
KR101007346B1 KR1020077012736A KR20077012736A KR101007346B1 KR 101007346 B1 KR101007346 B1 KR 101007346B1 KR 1020077012736 A KR1020077012736 A KR 1020077012736A KR 20077012736 A KR20077012736 A KR 20077012736A KR 101007346 B1 KR101007346 B1 KR 101007346B1
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sirna
binding energy
combination
target mrna
factor
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KR20070094601A (ko
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최영철
박한오
정소림
김영주
김상수
박성민
김상철
윤규만
최경옥
강효진
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(주)바이오니아
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50—Mutagenesis
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020077012736A 2004-12-08 2005-12-08 표적 mrna와 상보적인 염기서열을 가지는 sirna를 이용하여표적 mrna의 발현을 억제하는 방법 Expired - Fee Related KR101007346B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020040103283 2004-12-08
KR20040103283 2004-12-08
PCT/KR2005/004207 WO2006062369A1 (en) 2004-12-08 2005-12-08 Method of inhibiting expression of target mrna using sirna consisting of nucleotide sequence complementary to said target mrna

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KR20070094601A KR20070094601A (ko) 2007-09-20
KR101007346B1 true KR101007346B1 (ko) 2011-01-13

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US (1) US20090155904A1 (enExample)
EP (1) EP1828415A4 (enExample)
JP (1) JP4672021B2 (enExample)
KR (1) KR101007346B1 (enExample)
CN (1) CN101120099B (enExample)
WO (1) WO2006062369A1 (enExample)

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MX2015014666A (es) 2013-04-17 2016-03-01 Pfizer Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
CN105176999A (zh) * 2015-08-13 2015-12-23 吉林大学 抑制survivin基因表达的双链siRNA、其应用及包含其的表达质粒及传递体
CN105063048A (zh) * 2015-08-13 2015-11-18 吉林大学 一种抑制Survivin基因表达的siRNA及其应用
CN112951322B (zh) * 2021-03-08 2023-09-26 深圳市新合生物医疗科技有限公司 一种基于网格搜索的规则权重分配siRNA设计方法

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CN1427008A (zh) * 2001-12-14 2003-07-02 殷冬生 设计与选择天然的siRNA作为基因药物的方法及药物配方
US20040002083A1 (en) * 2002-01-29 2004-01-01 Ye Ding Statistical algorithms for folding and target accessibility prediction and design of nucleic acids
DK2284266T3 (da) * 2002-11-14 2014-01-13 Thermo Fisher Scient Biosciences Inc sIRNA-MOLEKYLE MOD TP53

Non-Patent Citations (1)

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Title
Biochem. Biophys. Res. Commun., Vol.319, No.1, pp.264-274(2004.06.18.) 1부.*

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WO2006062369A1 (en) 2006-06-15
JP4672021B2 (ja) 2011-04-20
US20090155904A1 (en) 2009-06-18
EP1828415A4 (en) 2009-07-01
KR20070094601A (ko) 2007-09-20
EP1828415A1 (en) 2007-09-05
CN101120099A (zh) 2008-02-06
JP2008522613A (ja) 2008-07-03
CN101120099B (zh) 2010-12-15

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