KR101002967B1 - Composition of antismoking aid and its manufacturing method - Google Patents

Abstract

PURPOSE: An anti-smoking composition containing Nicotiana tabacum oil is provided to help a smoker quit smoking for health life. CONSTITUTION: An anti-smoking composition contains 10-30 weight% of Nicotiana tabacum oil having 8-12 weight% of tabanone, 30-70 weight% of propylene glycol, 10-30 weight% of glycerol, 1-30 weight% of tobacco perfume. The tobacco perfume is vanilla, menthol, linalool, 2,5-dimethylpyrazine or 2-acetylpyrazine.

Description

Auxiliary composition for smoking cessation and its manufacturing method

The present invention relates to a non-smoking adjuvant composition and a method for producing the same, which are used for the purpose of reducing or satisfying a smoking desire.

More specifically, the present invention relates to a tobacco-free adjuvant composition and a method for producing the same, comprising tobacco oil containing 8 to 12% by weight of tabanone.

Generally speaking, cigarettes are a favorite item, but smoking cigarettes is an enormous damage to you and others. According to statistics from the World Health Organization, 4.9 million people die every year from smoking.

Most smokers fail to quit because they have difficulty coping with withdrawal from nicotine addiction. Nicotine is a low molecular weight alkaloid, and even small amounts of nicotine are harmful to the human body. The most harmful ingredient in cigarettes is tar, which is produced by the burning of cigarettes. Tobacco is composed of more than 4,000 components, most of which are carcinogenic, which directly damages the respiratory tract and is absorbed by the lungs. It has been known to cause various diseases including cancer in the organs of our bodies as well as to cause aging in all tissues and cells, leading to premature death. In particular, the surrounding people are harmed by secondhand smoke.

Because of the harmfulness of cigarettes, many people want to quit smoking, but a survey of smoking cessation in the United States found that more than 1 million people start smoking every year, and more than three quarters of them smoke again within 12 months. This is due to nicotine, a strong addictive substance found in cigarettes. The withdrawal symptoms such as sleep disorders, vomiting, headaches, and overeating that occur during smoking tend to last for several weeks or months after quitting. It is very difficult to succeed.

Therefore, various types of smoking aids such as food, gum, saliva, and patches have been developed for many smokers who want to quit smoking.

The most commonly used is nicotine supplements to supply nicotine to the body except other harmful components of cigarettes to treat withdrawal symptoms caused by smoking cessation and to reduce the need for smoking cessation. Nicotine patches for absorption, nicotine gum in which nicotine is absorbed through the mucous membrane in the mouth, and electronic cigarettes containing nicotine. However, the nicotine gum or nicotine patch has been shown to temporarily reduce the smoking desire of non-smokers only when used, and it is not good for health because the absorption of nicotine is persistent, and after a certain time due to the lifestyle of smokers who want to maintain smoking habits Re-feeling the need for smoking did not really help to quit smoking. In the case of e-cigarettes, there is an effect of reducing smoking desire while maintaining smoking habits, but it is also difficult to absolutely stop smoking due to the inhalation of nicotine.

In addition to nicotine-containing anti-smoking aids, anti-smoking aids (non-smoking) have been developed to include a composition for inhibiting smoking to inhale similarly to conventional smoking methods, but most of the anti-smoking aids are used to induce discomfort when smoking cigarettes. Composed of a composition or bitter or tasteless substance, smokers often feel too low to continue smoking cessation.

The present invention relates to a smoking cessation aid composition containing tobacco oil, the smoking cessation adjuvant composition of the present invention does not contain nicotine or tar components, it is beneficial to health while maintaining the habit of smoking, feel the taste and smell of tobacco, etc. It has been confirmed that it can lower or satisfy the smoking desire. In addition, since the non-smoking adjuvant composition of the present invention is manufactured in a form that can be inhaled while being vaporized in a liquid composition rather than inhaled by combustion, it can be used in an electronic smoker that is commonly used. There is no danger of smoking.

Tobacco milk prepared by the method of the present invention contains 8 to 12% by weight of tabanone (tabanone), as a composition containing tobacco oil or tabanone until now is registered in Korea as a tobacco spice to improve the flavor of tobacco Patent No. 583891, Korean Patent No. 369460, US Patent No. 5005593, No. 4506682, etc. are known for the method of extracting tobacco oil or tabanone, but it is not the use of the anti-smoking supplement composition of the present invention, extraction The method is also another patent.

It is an object of the present invention to provide a smoking cessation aid composition used for the purpose of reducing or satisfying the smoking desire.

Still another object of the present invention is to provide a smoking cessation aid composition comprising tobacco oil containing 8 to 12% by weight of tabanone.

The tachocco volatile oil contained in the smoking cessation aid composition of the present invention,

Removing stems and roots from tobacco plants and selecting only tobacco leaves (tabacco leaf);

Drying the tobacco leaves selected to have a water content of 2.5% or less;

Grinding the dried tobacco leaves into fine powder or powder;

Extracting tobacco essence oil by adding a mixture of water, ethanol and propylene glycol to the ground tobacco leaf;

Removing oil and nicotine having a high molecular weight by fractional distillation at 0.05 MPa reduced pressure to atmospheric pressure and at a temperature of 60 to 90 ° C., and extracting only tobacco oil containing the main flavor component of tobacco;

Sterilizing the extracted tobacco oil;

It is prepared to include.

The pressure reduction pressure during the fractional distillation is possible under the condition of 0.05MPa or more and less than the normal pressure, but fine pressure reduction conditions of 0.09 to 0.1MPa are appropriate.

Drying of the tobacco leaf may be naturally dried at room temperature for 12 to 48 hours, it is also possible to use a dryer commonly used to dry plant raw materials.

The extract solvent of the tobacco leaf is preferably mixed with water, ethanol and propylene glycol in a weight ratio of 1 to 2: 1 to 4: 1 to 10.

Water, ethanol and propylene glycol mixture is appropriate to use 2 to 20 times the weight of tobacco leaf, solvent extraction time is good 12 ~ 36 hours and extraction temperature is extracted from 40 ~ 80 ℃ to 130 ~ 170 ℃ during extraction time It is good to raise the temperature.

Fractional distillation time of the tobacco essence oil can be carried out for 2 to 36 hours.

Sterilization of the tobacco colostrum may be performed for 0.5 to 3 hours, and may be used as an ultrasonic sterilizer for sterilization of foods in general. In addition to ultrasonic sterilization, a sterilization method using an ultraviolet sterilizer or an infrared sterilizer may be used.

Anti-smoking supplement composition of the present invention with respect to 100% of the total weight,

10 to 30% by weight of tabacco volatile oil containing 8 to 12% by weight of tabanone prepared by the above method;

Propylene glycol 30 to 70% by weight;

Glycerol 10-30 wt%; And

Tobacco spices 1-30% by weight;

It includes.

Propylene glycol in the composition has the effect of generating smoke when smoking the smoking cessation aid composition as a solvent, glycerol can also bring about the effect of generating smoke. Tobacco spice is a spice commonly used in the field, such as vanilla, menthol, linalul, 2,5-dimethylpyrazine, 2-acetylpyrazine, and is a tobacco scent that exists in tobacco or enhances the taste and aroma of tobacco. It is a spice added to make. In addition, spices that may be included in the non-smoking supplement composition include benzyl alcohol, phenylethyl alcohol, isophorone, anisaldehyde, solanone, damasenone ( damascenone, damascone, methylpyrazine, 2,6-dimethylpyrazine, ethylpyrazine, 2,5-dimethylpyrazine, 2-ethyl-6-vinylpyrazine and the like can be used.

More specifically, the anti-smoking aid composition of the present invention is based on 100% by weight

10 to 30% by weight of tabacco volatile oil containing 8 to 12% by weight of tabanone prepared by the above method;

Propylene glycol 30 to 70% by weight;

Glycerol 10-30 wt%; And

1-10% by weight of vanilla;

Menthol 0.1-5 wt%;

Linalool 0.1-5% by weight;

0.1-5% by weight of 2,5-dimethylpyrazine; And

0.1-5% by weight of 2-acetylpyrazine;

It may include.

The non-smoking adjuvant composition mixed in the above ratio was put in a mixing tank and stirred 30 to 60 times per minute, mixed uniformly at 25 to 40 ° C for 10 to 60 minutes, and after the mixing was completed, the final anti-smoking adjuvant was removed by removing bubbles contained in the composition. Used as a composition.

The mixing tank may use a mixing tank that is commonly used to mix food ingredients.

The composition of the present invention can be used in a smoking cessation assisted electronic smoker.

The tobacco oil is a yellowish-brown clear liquid with a tobacco aroma, and contains 8 to 12% by weight of tabanone (also referred to as megastigmatrienone) as a reference material. Tabanone is in the form of an isomer that shows four peaks when analyzed by gas chromatography. The non-smoking adjuvant composition prepared by using the tobacco oil having a concentration of less than 8% of the tavanone content of the manufactured tobacco colostrum has a weak tobacco flavor and thus has a low palatability as a smoking cessation aid, while the tobacco content exceeds 12% of the tavanone content. The smoking cessation adjuvant composition prepared using tobacco oil has a too strong tobacco flavor, accompanied by vomiting or nausea, and also has a low preference as a smoking cessation aid. This is because the distribution of tobacco-flavoring ingredients is different and the taste and aroma are different as the content of tavanone, which is a standard of tobacco colostrum, is changed. As a result, a smoking cessation aid composition containing tobacco colostrum containing 8 to 12% by weight of tavanone is contained. It shows that the palatability as this smoking cessation aid is very excellent.

[Formula 1]

In addition, if the tobacco content of tobacco containing less than 10% by weight of tobacco containing 8-12% by weight relative to 100% of the total weight of the non-smoking adjuvant composition is less than 10% by weight, the tobacco scent of the non-smoking adjuvant composition is too weak and the preference as a non-smoking adjuvant When the content of tobacco oil containing 8 to 12% by weight of tavanone exceeds 30% by weight, the tobacco aroma is too strong, accompanied by vomiting or nausea, and also a low smoking aid.

The proper amount of tabanone as the smoking cessation aid composition is when the total tabanone content of the smoking cessation aid composition is 0.5 to 5%, suitably 0.8 to 3.6% is more preferable, and more preferably 1.5 to 2.5%.

The use of the anti-smoking supplement composition of the present invention does not contain various harmful ingredients such as nicotine and tar generated by smoking to help the healthy life of the smoker, while maintaining the smoking habits at the same time to produce a non-smoking effect, excellent satisfaction to smokers Side effects can be minimized while maintaining, which in turn increases the success rate of smoking cessation.

1 is a flowchart illustrating a process of preparing a smoking cessation aid composition.
Figure 2 is a flow chart showing a process for producing a colostrum milk.
Figure 3 is a graph showing the results of analyzing the colostrum oil by gas chromatography (Gas chromatography).

Hereinafter, a preferred embodiment of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, it is provided to ensure that the contents introduced herein are thorough and complete, and that the spirit of the present invention to those skilled in the art can fully convey.

<Example 1. Preparation of smoking cessation aid composition-control of temperature during fractional distillation of tobacco colostrum>

1-1. Fractional distillation temperature: 80 ℃

Tobacco leaf was selected and dried 100kg of tobacco leaf selected so that the moisture content is less than 2.5%. The dried tobacco leaves were ground into fine powder, and water, ethanol and propylene glycol were mixed in a weight ratio of 1: 1: 1, and then 1000 kg of mixed solution was added to continuously increase the temperature from 60 ° C to 150 ° C for 24 hours. 1 kg of oil was extracted. The tobacco essence oil was distilled at a temperature of 80 ° C. and a pressure of 0.1 MPa according to a fractional distillation method to remove oil having a high molecular weight and nicotine components, thereby preparing 500 g of tobacco oil containing tobacco flavor components and ultrasonic sterilization for 1 hour. The treatment finally yielded tobacco oil.

The non-smoking adjuvant composition was prepared by mixing 200 g of vinegared colostrum, 500 g of propylene glycol, 200 g of glycerol, 50 g of vanilla, 20 g of linoleum, 10 g of 2,5-dimethylpyrazine, 10 g of 2-acetylpyrazine, and mixing the mixture at 30 ° C. After stirring for 30 minutes, 45 times per minute, it was finally prepared as a smoking cessation aid composition.

1-2. Fractional distillation temperature: 60 ℃

Tobacco oil was prepared under the same conditions as in Example 1-1, but the fractionation distillation temperature of tobacco essence oil was adjusted to 60 ° C.

1-3. Fractional distillation temperature: 90 ℃

Tobacco oil was prepared under the same conditions as in Example 1-1, but the fractionation distillation temperature of tobacco essence oil was adjusted to 90 ° C.

<Example 2. Preparation of smoking cessation aid composition-control of pressure during fractional distillation of tobacco colostrum>

2-1. Fractional distillation pressure: 0.05MPa

Tobacco oil was prepared under the same conditions as in Example 1-1, but the fractional distillation pressure of tobacco essence oil was adjusted under reduced pressure to 0.05 MPa.

2-2. Fractional distillation pressure: 0.07MPa

Tobacco oil was prepared under the same conditions as in Example 1-1, but the fractional distillation pressure of tobacco essence oil was adjusted under reduced pressure to 0.07 MPa.

 2-3. Fractional distillation pressure: 0.09MPa

Tobacco oil was prepared under the same conditions as in Example 1-1, but the fractional distillation pressure of tobacco essence oil was adjusted to 0.09 MPa under reduced pressure.

 2-4. Fractional distillation pressure: Normal pressure

Tobacco oil was prepared under the same conditions as in Example 1-1, but the fractionation distillation pressure of tobacco essence oil was adjusted to an atmospheric pressure of 0.101325 MPa (1 atm).

<Example 3. Preparation of smoking cessation aid composition-extraction solvent control of tobacco colostrum>

To prepare a tobacco oil under the same conditions as in Example 1-1, 1000kg of a mixed solution of water: ethanol: propylene glycol in a 1: 3: 9 weight ratio was used as the extraction solvent.

Example 4 Preparation of Smoking Auxiliary Aid Composition-Control of Tobacco Oil Content

4-1. 10% of colostrum oil of Example 1-1

To prepare a non-smoking adjuvant composition under the same conditions as in Example 1-1, 100g of colostrum, 600g of propylene glycol to prepare a non-smoking adjuvant composition.

4-2. 30% of colostrum oil of Example 1-1

A smoking cessation adjuvant composition was prepared under the same conditions as in Example 1-1, but a smoking cessation adjuvant composition was prepared using 300 g of colostrum oil and 400 g of propylene glycol.

4-3. 10% of colostrum oil of Example 1-2

To prepare a non-smoking adjuvant composition under the same conditions as in Example 1-2, but using a colostrum oil 100g, propylene glycol 600g to prepare a non-smoking adjuvant composition.

4-4. 30% of colostrum oil of Example 1-2

To prepare a non-smoking adjuvant composition under the same conditions as in Example 1-2, but using a colostrum oil 300g, propylene glycol 400g to prepare a non-smoking adjuvant composition.

4-5. 10% of colostrum oil of Example 1-3

To prepare a non-smoking adjuvant composition under the same conditions as in Example 1-3, 100g of colostrum, 600g of propylene glycol to prepare a non-smoking adjuvant composition.

4-6. 30% of colostrum oil of Example 1-3

A smoking cessation aid composition was prepared under the same conditions as in Example 1-3, but a smoking cessation aid composition was prepared using 300 g of tobacco oil and 400 g of propylene glycol.

<Comparative Example 1. Preparation of smoking cessation aid composition-control of temperature during fractional distillation of tobacco colostrum>

1-1. Fractional distillation temperature: 55 ℃

Tobacco oil was prepared under the same conditions as in Example 1-1, but the fractionation distillation temperature of tobacco essence oil was adjusted to 55 ° C.

1-2. Fractional distillation temperature: 95 ℃

Tobacco oil was prepared under the same conditions as in Example 1-1, but the fractional distillation temperature of tobacco essence oil was adjusted to 95 ° C.

<Comparative Example 2. Preparation of anti-smoking supplement composition-Control of pressure during fractional distillation of tobacco colostrum>

2-1. Fractional distillation pressure: 0.03 MPa

Tobacco oil was prepared under the same conditions as in Example 1-1, but the fractional distillation pressure of tobacco essence oil was adjusted to 0.03 MPa under reduced pressure.

2-2. Fractional distillation pressure: 0.04 MPa

Tobacco oil was prepared under the same conditions as in Example 1-1, but the fractional distillation pressure of tobacco essence oil was adjusted to 0.04 MPa under reduced pressure.

<Comparative Example 3. Preparation of Smoking Auxiliary Aid Composition-Controlling Extraction Solvent of Tobacco Colostrum>

3-1. Water: Methanol: Propylene Glycol mixed in 1: 1: 1 weight ratio

To prepare a tobacco oil under the same conditions as in Example 1-1, but was mixed with water: methanol: propylene glycol in a 1: 1: 1 weight ratio as an extraction solvent was used 1000kg.

3-2. Water: Ethanol: Methanol in 1: 1: 1 weight ratio

To prepare a colostrum oil under the same conditions as in Example 1-1, but was mixed with water: ethanol: methanol 1: 1: 1 as an extraction solvent was used 1000kg.

3-3. Water: Ethanol: Isopropanol is used in a 1: 1: 1 weight ratio

To prepare a colostrum oil under the same conditions as in Example 1-1, but was mixed with water: ethanol: isopropanol in a 1: 1: 1 weight ratio as an extraction solvent was used 1000kg.

3-4. Water: isopropanol: propylene glycol mixed in a 1: 1: 1 weight ratio

To prepare a tobacco oil under the same conditions as in Example 1-1, but was mixed with water 1: isopropanol: propylene glycol in a 1: 1: 1 weight ratio as an extraction solvent was used 1000kg.

3-5. Water: Methanol: Propylene glycol is mixed in a 1: 3: 9 weight ratio

To prepare the tobacco oil under the same conditions as in Example 1-1, but 1000kg was used by mixing 77kg of water, 231kg of methanol, 693kg of propylene glycol as an extraction solvent.

3-6. Water: Ethanol: Methanol 1: 3: 9 weight ratio mixed use

To prepare a tobacco oil under the same conditions as in Example 1-1, but 1000kg was used by mixing 77kg of water, 231kg of ethanol, 693kg of methanol as an extraction solvent.

3-7. Water: Ethanol: Isopropanol is mixed in a 1: 3: 9 weight ratio

To prepare a tobacco oil under the same conditions as in Example 1-1, but 1000kg was used by mixing 77kg of water, 231kg of ethanol, 693kg of isopropanol as an extraction solvent.

3-8. Water: Isopropanol: Propylene glycol is mixed in a 1: 3: 9 weight ratio

Tobacco oil was prepared under the same conditions as in Example 1-1, but 77 kg of water, 231 kg of isopropanol, and 693 kg of propylene glycol were used as an extraction solvent.

3-9. Water: Ethanol is mixed in a 1: 1 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, but was used by mixing 500kg of water, 500kg of ethanol as a solvent extract.

3-10. Use of ethanol: propylene glycol in 1: 1 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, but was used by mixing 500kg of ethanol, 500kg of propylene glycol as a solvent extract.

3-11. Water: propylene glycol is mixed in a 1: 1 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, but was used by mixing 500kg of water, 500kg of propylene glycol as a solvent extract.

3-12. Water: Methanol is mixed at 1: 1 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, but was used by mixing 500kg of water, 500kg of methanol as a solvent extract.

3-13. Water: Isopropanol is mixed in a 1: 1 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, but was used by mixing 500kg of water, 500kg of isopropanol as a solvent extract.

3-14. Methanol: Propylene glycol mixed in a 1: 1 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, but was used by mixing 500kg of methanol, 500kg of propylene glycol as a solvent extract.

3-15. Ethanol: Methanol 1: 1 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, but was used by mixing 500kg of ethanol, 500kg of methanol as a solvent extract.

3-16. Ethanol: Isopropanol 1: 1 mixed ratio

To prepare the tobacco oil under the same conditions as in Example 1-1, but was used by mixing 500kg of ethanol, 500kg of isopropanol as a solvent extract.

3-17. Water: Methanol is mixed at 1: 1 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, but was used by mixing 500kg of water, 500kg of methanol as a solvent extract.

3-18. Water: Isopropanol is mixed in a 1: 1 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, but was used by mixing 500kg of water, 500kg of isopropanol as a solvent extract.

3-19. Water: Ethanol is mixed in a 1: 5 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, 1000kg was used by mixing 167kg of water and 835kg of ethanol as the solvent extract.

3-20. Ethanol: water mixed in a 1: 5 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, 1000kg was used by mixing 167kg of ethanol and 835kg of water as the extractant.

3-21. Use of ethanol: propylene glycol in a 1: 5 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, 1000kg was used by mixing 167kg of ethanol and 835kg of propylene glycol as the extractant of the colostrum.

3-22. Propylene glycol: ethanol mixed at 1: 5 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, 1000kg was used by mixing 167kg of propylene glycol, 835kg of ethanol as the extractant.

3-23. Water: Propylene Glycol is mixed in a 1: 5 weight ratio.

To prepare the colostrum under the same conditions as in Example 1-1, 1000kg was used by mixing 167kg of water and 835kg of propylene glycol as a solvent extract.

3-24. Propylene Glycol: Water mixed in a 1: 5 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, 1000kg was used by mixing 167kg of propylene glycol and 835kg of water as the extractant of the colostrum.

3-25. Water: Methanol 1: 5 weight ratio mixed use

To prepare the colostrum under the same conditions as in Example 1-1, 1000kg was used by mixing 167kg of water and 835kg of methanol as a solvent extract.

3-26. Methanol: water mixed in a 1: 5 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, 1000kg was used by mixing 167kg of methanol and 835kg of water as the extractant.

3-27. Methanol: Propylene glycol is mixed in a 1: 5 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, 1000kg was used by mixing 167kg of methanol, 835kg of propylene glycol as the extractant of the colostrum.

3-28. Propylene Glycol: Methanol 1: 5 weight ratio

To prepare a tobacco oil under the same conditions as in Example 1-1, 1000kg was used by mixing 167kg of propylene glycol and 835kg of methanol as a solvent extract.

3-29. Water: Isopropanol is mixed in a 1: 5 weight ratio

To prepare a tobacco oil under the same conditions as in Example 1-1, 1000kg was used by mixing 167kg of water and 835kg of isopropanol as a solvent extract.

3-30. Isopropanol: mixed with water at 1: 5 weight ratio

To prepare the colostrum under the same conditions as in Example 1-1, 1000kg was used by mixing 167kg of isopropanol and 835kg of water as the extractant.

3-31. Use only ethanol

To prepare the colostrum under the same conditions as in Example 1-1, but 1000kg of ethanol was used as the solvent extract.

3-32. Use only propylene glycol

To prepare the colostrum under the same conditions as in Example 1-1, 1000kg of propylene glycol was used as the extractant.

3-33. Use methanol

To prepare a tobacco oil under the same conditions as in Example 1-1, but 1000kg of methanol used to prepare tobacco oil or to extract the tabanone was used.

3-34. Use isopropanol

To prepare the tobacco oil under the same conditions as in Example 1-1, 1000 kg of isopropanol used when preparing tobacco oil or extracting tabanone was used.

<Comparative Example 4. Preparation of smoking cessation adjuvant composition-control of tobacco content

4-1. 7% of colostrum oil of Example 1-1

A smoking cessation aid composition was prepared under the same conditions as in Example 1-1, but a smoking cessation aid composition was prepared using 70 g of tobacco oil and 630 g of propylene glycol.

4-2. 33% of colostrum oil of Example 1-1

A smoking cessation aid composition was prepared under the same conditions as in Example 1-1, but a smoking cessation aid composition was prepared using 330 g of tobacco oil and 370 g of propylene glycol.

4-3. Tobacco oil 7% of Example 1-2

A smoking cessation aid composition was prepared under the same conditions as in Example 1-2, but a smoking cessation aid composition was prepared using 70 g of tobacco oil and 630 g of propylene glycol.

4-4. 33% of colostrum oil of Example 1-2

A smoking cessation aid composition was prepared under the same conditions as in Example 1-2, but a smoking cessation aid composition was prepared using 330 g of tobacco oil and 370 g of propylene glycol.

4-5. Colostrum oil 7% of Example 1-3

To prepare a smoking cessation adjuvant composition under the same conditions as in Example 1-3, but using a colostrum oil 70g, 630g of propylene glycol to prepare a smoking cessation adjuvant composition.

4-6. 33% of colostrum oil of Examples 1-3

To prepare a smoking cessation adjuvant composition under the same conditions as in Example 1-3, but was prepared by using 330g of tobacco colostrum, 370g of propylene glycol.

4-7. 7% of colostrum oil of Comparative Example 1-1

To prepare a non-smoking adjuvant composition under the same conditions as in Comparative Example 1-1, but using a colostrum oil 70g, 630g of propylene glycol to prepare a non-smoking adjuvant composition.

4-8. 33% of colostrum oil of Comparative Example 1-1

To prepare a non-smoking adjuvant composition under the same conditions as in Comparative Example 1-1, but using a colostrum oil 330g, 370g of propylene glycol to prepare a non-smoking adjuvant composition.

4-9. Tobacco oil 7% of Comparative Example 1-2

To prepare a non-smoking adjuvant composition under the same conditions as in Comparative Example 1-2, but using a colostrum oil 70g, 630g of propylene glycol to prepare a non-smoking adjuvant composition.

4-10. 33% of colostrum oil of Comparative Example 1-2

To prepare a non-smoking adjuvant composition under the same conditions as in Comparative Example 1-2, but was prepared by using 330g of tobacco colostrum, 370g of propylene glycol.

Experimental Example 1 Tabanon Content of Colostrum Milk

In order to determine the tabanone content of the colostrum of Examples 1 and 2 and Comparative Examples 1 and 2 of the present invention, it was measured by gas chromatography, and Agilent 6890 GC system (with autosampler) and HP-Ultra 2 A column of (50m ㅧ 0.32mm id, 0.52μm of phenylmethylsiloxane) was used, and helium was used as a carrier gas (1.7ml / min). The oven temperature was initially increased from 60 ° C. to 3.5 ° C./min to 170 ° C. and then maintained for 5 minutes. Thereafter, the temperature was increased to 240 ° C. at 6 ° C./min, and the temperature was maintained for an analysis time of 70 minutes. Injector was maintained at 260 ℃, injection was 1µl (split ratio = 60: 1), and detector maintained FID 280 ℃. As a result of Table 1, it was confirmed that the tavanone content of the tobacco material manufactured by the method of the present invention is 8 to 12% by weight, and the tobacco material prepared by the method of Comparative Example, which is other conditions, has a tabanon content less than 8% by weight. Or greater than 12% by weight was also found. In addition, it can be confirmed that the tabanone content of the colostrum oil depends on the solvent type mixed with the extraction solvent when preparing the tobacco essence oil from the tobacco leaf, and the appropriate fractional distillation extraction temperature and pressure when the tobacco essence oil is prepared from the tobacco essence oil. there was.

Condition Tabanon Content of Tobacco Colostrum Example 1-1 12.0 Example 1-2 10.3 Example 1-3 8.0 Example 2-1 8.2 Example 2-2 8.7 Example 2-3 9.1 Examples 2-4 8.1 Example 3 9.7 Comparative Example 1-1 7.1 Comparative Example 1-2 13.1 Comparative Example 2-1 6.0 Comparative Example 2-2 15.2 Comparative Example 3-1 7.1 Comparative Example 3-2 7.2 Comparative Example 3-3 6.9 Comparative Example 3-4 6.5 Comparative Example 3-5 6.9 Comparative Example 3-6 6.5 Comparative Example 3-7 5.2 Comparative Example 3-8 5.1 Comparative Example 3-9 5.2 Comparative Example 3-10 5.3 Comparative Example 3-11 5.2 Comparative Example 3-12 5.4 Comparative Example 3-13 5.4 Comparative Example 3-14 5.5 Comparative Example 3-15 5.2 Comparative Example 3-16 5.2 Comparative Example 3-17 5.3 Comparative Example 3-18 5.6 Comparative Example 3-19 5.8 Comparative Example 3-20 5.5 Comparative Example 3-21 5.6 Comparative Example 3-22 5.7 Comparative Example 3-23 5.8 Comparative Example 3-24 5.9 Comparative Example 3-25 5.8 Comparative Example 3-26 5.5 Comparative Example 3-27 5.3 Comparative Example 3-28 5.2 Comparative Example 3-29 5.3 Comparative Example 3-30 5.4 Comparative Example 3-31 5.5 Comparative Example 3-32 5.6 Comparative Example 3-33 5.8 Comparative Example 3-34 5.8

<Experimental Example 2 Comparison of Acceptability and Smoking Cessation Effects of Anti-Smoking Aid Composition>

In the method of preparing the colostrum, the method of Examples 1, 2 and Comparative Examples 1, 2 to determine how the control of temperature, pressure, extraction solvent affects the palatability and smoking cessation effect of the anti-smoking aid composition 50 adult men and women (selected as those who smoke less than 10 cigarettes per day) are put into a group of electronic smokers using a conventional smoking cessation aid composition to use each composition for one month. It was. One month later, we compared the experience of attempting to quit smoking with the 10-point scale (higher score is better) to evaluate the anti-smoking supplement composition.The evaluation items were the satisfaction level of smoking cessation, personal preference for the non-smoking supplement composition, and re-smoking. Inhibition of will and inhibition of withdrawal were evaluated, and the success rate of quitting smoking was also recorded. In addition, nicotine gum, nicotine patches, and non-smoking candles commonly used in the market were also used for the same period.

Condition No smoking satisfaction Personal preference Re-smoking will restrain Inhibit withdrawal Sustained smoking cessation rate (%) Example 1-1 9.4 9.4 9.3 7.7 91 Example 1-2 8.5 9.5 8.4 8.6 89 Example 1-3 9.3 9.3 9.2 8.5 91 Example 2-1 8.3 8.9 8.9 9.1 89 Example 2-2 8.1 8.8 9.1 9.0 88 Example 2-3 8.3 8.8 9.2 8.5 91 Examples 2-4 8.9 9.3 8.9 8.5 89 Example 3 8.5 8.3 9.3 8.5 88 Comparative Example 1-1 4.3 4.3 3.7 3.4 51 Comparative Example 1-2 6.2 5.4 2.4 3.2 59 Comparative Example 2-1 6.0 5.6 2.5 3.3 52 Comparative Example 2-2 5.8 5.9 2.3 3.1 59 Comparative Example 3-1 5.5 6.3 3.4 3.5 52 Comparative Example 3-2 5.6 6.3 3.3 3.4 52 Comparative Example 3-3 4.3 4.8 3.2 3.5 53 Comparative Example 3-4 4.2 4.3 3.3 3.4 53 Comparative Example 3-5 4.3 4.0 3.4 3.3 52 Comparative Example 3-6 4.4 4.3 3.2 3.5 55 Comparative Example 3-7 4.5 4.5 3.3 3.4 53 Comparative Example 3-8 4.6 4.3 3.4 3.6 56 Comparative Example 3-9 4.7 4.2 3.5 3.5 45 Comparative Example 3-10 4.6 4.3 3.4 3.4 43 Comparative Example 3-11 4.4 4.1 3.6 3.7 43 Comparative Example 3-12 4.5 4.3 3.3 3.4 42 Comparative Example 3-13 4.3 4.4 3.4 3.5 43 Comparative Example 3-14 4.4 4.5 3.2 3.4 44 Comparative Example 3-15 4.5 4.4 3.6 3.7 46 Comparative Example 3-16 4.3 4.7 3.7 3.6 44 Comparative Example 3-17 4.4 4.6 3.8 3.5 45 Comparative Example 3-18 4.4 4.5 3.5 3.4 43 Comparative Example 3-19 4.3 4.4 3.4 3.5 46 Comparative Example 3-20 4.4 4.3 3.5 3.6 48 Comparative Example 3-21 4.6 4.3 3.4 3.6 45 Comparative Example 3-22 4.4 4.5 3.3 3.4 45 Comparative Example 3-23 4.5 4.5 3.6 3.2 45 Comparative Example 3-24 4.6 4.5 3.7 3.2 47 Comparative Example 3-25 4.4 4.7 3.8 3.4 44 Comparative Example 3-26 4.7 4.7 3.8 3.3 42 Comparative Example 3-27 4.5 4.3 3.5 3.5 44 Comparative Example 3-28 4.6 4.7 3.6 3.4 44 Comparative Example 3-29 4.4 4.6 3.4 3.3 47 Comparative Example 3-30 4.3 4.5 3.3 3.8 48 Comparative Example 3-31 4.2 4.4 3.2 3.8 45 Comparative Example 3-32 4.7 4.5 3.5 3.7 46 Comparative Example 3-33 4.8 4.7 3.7 3.7 47 Comparative Example 3-34 4.9 4.4 3.8 3.6 44 Nicotine Gum 2.5 2.3 2.3 1.6 42 Nicotine patch 2.3 2.5 2.3 1.5 42 Smoking 3.3 3.3 2.4 2.4 51

Through the results of Table 2, it can be seen that the smoking cessation aid composition prepared under the conditions disclosed in the Examples of the present invention showed an excellent smoking cessation effect compared to the smoking cessation aid composition of the comparative example and nicotine gum and nicotine patch, commonly used smoking cessation The anti-smoking aid composition having a good anti-smoking effect was found to be 8 to 12% by weight of tavanone content of colostrum as a result of Table 1.

<Experimental Example 3 Comparison of Tabanon Total Content, Palatability and Smoking Cessation Effect of Anti-Smoking Aid Composition>

Since the smoking cessation effect of Experimental Example 2 may be due to the total tabanone content of the smoking cessation aid composition rather than the tabanone content of the vinegared milk, Experimental Example 1 by selecting the representative of the distribution of the content of colostrum in the smoking cessation aid composition The preference and smoking cessation effects were compared.

The total tabanone content was calculated according to [Content contained in tobacco oil × total content of tobacco oil in the composition].

Condition Tabanone content of tobacco oil itself (%) Tobacco oil content (%) in the anti-smoking supplement composition Total Tabanone Content (%) No smoking satisfaction personal
Likelihood Example 4-1 12.0 10 1.20 8.9 9.0 Example 4-2 12.0 30 3.60 9.2 9.3 Example 4-3 10.3 10 1.03 8.9 9.2 Example 4-4 10.3 30 3.09 9.4 8.9 Example 4-5 8.0 10 0.80 9.5 9.4 Example 4-6 8.0 30 2.40 9.5 8.7 Comparative Example 4-1 12.0 7 0.84 6.1 4.4 Comparative Example 4-2 12.0 33 3.96 6.1 4.5 Comparative Example 4-3 10.3 7 0.72 5.2 4.3 Comparative Example 4-4 10.3 33 3.40 4.3 4.2 Comparative Example 4-5 8.0 7 0.56 5.3 5.0 Comparative Example 4-6 8.0 33 2.64 4.2 4.4 Comparative Example 4-7 7.1 7 0.50 5.3 5.6 Comparative Example 4-8 7.1 33 2.34 5.2 4.7 Comparative Example 4-9 13.1 7 0.92 4.8 4.4 Comparative Example 4-10 13.1 33 4.32 4.9 4.3

The results in Table 3, when comparing the total tabanon content in the smoking cessation aid composition other than the tabanone content of the colostrum itself, the total tabanone content did not increase the smoking cessation satisfaction and personal preference.

In addition, it has been confirmed that tobacco smoke should be included in the anti-smoking supplement composition within 10 to 30% by weight to increase smoking satisfaction and personal preference. This is because when too much or too much tobacco oil is included, the taste and aroma of the cigarette is too light or too strong to decrease the satisfaction of smoking habits.

As a result, it was found that the smoking cessation aid composition of the embodiment using 8 to 12% by weight of tobacco oil containing tobacco tobacco increased only the smoking cessation satisfaction and personal preference, which means that the distribution of other components according to the It was analyzed that the preference for the colostrum was changed as it changed.

Claims (8)

Tobacco leaf extracted with a mixture of water, ethanol and propylene glycol, 10 to 30% by weight of colostrum oil containing 8 to 12% by weight of tabanone;
Propylene glycol 30-70 wt%;
Glycerol 10-30 wt%; And
Tobacco spices 1-30% by weight;
Smoking aid adjuvant composition comprising a. The method of claim 1,
The smoking cessation aid composition is a smoking cessation aid composition, characterized in that the tabanon content of 1.5 to 2.5% by weight of the total weight. The method of claim 1,
The tobacco oil is an anti-smoking supplement composition, characterized in that it does not contain nicotine. The method of claim 1,
The tobacco spice is vanilla, menthol, linalul, 2,5-dimethylpyrazine, 2-acetylpyrazine, non-smoking aid composition. delete A smoking cessation aid comprising the anti-smoking aid composition according to any one of claims 1 to 4. Removing stems and roots from tobacco plants and selecting only tobacco leaves;
Drying the tobacco leaf selected to less than 2.5% moisture content;
Grinding the dried tobacco leaves;
Extracting tobacco essence oil by adding a mixture of water, ethanol and propylene glycol to the ground tobacco leaf;
Removing the extracted tobacco essence oil at 60-90 ° C. temperature and 0.05 MPa to atmospheric pressure to remove oil having a high molecular weight and nicotine components and preparing tobacco oil; And
Ultrasonic sterilization of the manufactured tobacco colostrum;
Method for producing tobacco oil containing 8 to 12% by weight of tabanone by including a. 10 to 30% by weight of the colostrum oil prepared by the method of claim 7, 30 to 70% by weight of propylene glycol; Glycerol 10-30 wt%; Tobacco spices 1-30% by weight; mixing to prepare a mixture; And
Homogenizing the mixture by stirring 30 to 60 times per minute at 25 to 40 ° C. for 10 to 60 minutes;
Method of producing a smoking cessation aid composition comprising a.

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