KR100967226B1 - Method for making granule using ginseng and Hongkuk - Google Patents

Abstract

The present invention is to prepare a granule by using a ginseng powder crushed to a diameter of 10 ㎛ or less at a temperature condition of -196 ~ 30 ℃ and a red yeast powder crushed to a diameter of 10 ㎛ or less at a temperature condition of -196 ~ 30 ℃ It is about a method,

The fine powder prepared in the present invention has increased water solubility in water, making it easy to manufacture into granules, and improving the absorption rate in the small intestine at the time of ingestion.

Red yeast, fine, powder, extrusion, ginseng

Description

Method for making granules using ginseng and red ginseng {Method for making granule using ginseng and Hongkuk}

The present invention relates to a method for producing granules using ginseng and red yeast soup.

Panax ginseng Ginseng ) is a perennial root of Panax ginseng in the genus of plant taxonomy. It is known about 11 species on earth. Ginseng is usually harvested after 4-6 years of cultivation. Depending on the processing method, ginseng is untreated and classified into white ginseng, red ginseng and red ginseng.

Fresh ginseng has a moisture content of around 75%, making it difficult to store for a long time. Thus, dried white ginseng was developed using water ginseng over 4 years old so that the moisture content is less than 12%. The red ginseng processed to red color was developed by steaming the fresh ginseng or by drying the starch of the ginseng by other means. . Red ginseng contains a large amount of saponin called Ginsenoside, and phenolic compounds, which are anti-aging substances, and substances such as maltol component and saponin are produced during steaming.

On the other hand, red yeast rice is made by fermenting red yeast bacteria of Monascus in grains such as rice and barley, and has been used as the only herbal medicine among koji since ancient times.In China, alcohol, food and preservatives have been used for about 1000 years. It has been widely used as a natural pigment, medicine, and the like.

The pigments of red yeast rice are not only red but also yellow monascin and ankaflavin, orange rubropunctatin and monascorubrin, and red leu It has been found that more than 10 pigments, including brobrotamine and monascorubramine, are complex.

On the other hand, Monacolin-K (Monacolin-K), which is a component related to the circulatory system, has been found among the red yeast metabolites, and monacoline-K (Monacolin-K) is toxic. It is extremely low and at the same time has a strong cholesterol-lowering action, characterized by antagonistic inhibition of HMG-CoA reductase, lowering blood triglycerides and LDL-cholesterol levels, prevents arteriosclerosis and heart disease, It has been found to increase the level of beneficial HDL-cholesterol, and is widely used as a food additive and a health supplement in the United States, Europe, and Japan.

However, conventionally, granules have not been prepared using ginseng and red ginseng, and further, no granules have been known about the granules prepared using ginseng and red ginseng fine powder.

Accordingly, an object of the present invention is to provide a method for producing granules using fine powder of ginseng and red yeast rice.

In order to achieve the above object, the present invention provides a ginseng powder, which is crushed to a diameter of 10 μm or less under a temperature condition of -196 to 30 ° C. and a crushed to a diameter of 10 μm or less under a temperature condition of -196 to 30 ° C. Provided is a method for producing granules using ginseng and red ginseng, characterized in that the granules are prepared by mixing a red ginseng powder and then adding a binder.

In addition, the present invention, as a second aspect, the step of forming a core by adding a binder to the crushed ginseng powder to a diameter of 10 ㎛ or less at a temperature condition of -196 ~ 30 ℃; It provides a method for producing granules using ginseng and red ginseng comprising the; coating the surface of the molded core with red ginseng powder crushed to a diameter of 10 ㎛ or less at a temperature of -196 ~ 30 ℃ do.

In addition, the present invention, as a third aspect, the step of forming a core by adding a binder to the crushed red yeast powder to a diameter of 10 ㎛ or less at a temperature of -196 ~ 30 ℃; It provides a method for producing granules using ginseng and red ginseng comprising the step of coating the surface of the molded core with ginseng powder crushed to a diameter of 10 ㎛ or less at a temperature of -196 ~ 30 ℃ do.

In addition, the present invention provides a ginseng powder that is crushed to have a diameter of 10 μm or less under a temperature condition of -196 to 30 ° C., and a red ginseng powder that has been crushed to have a diameter of 10 μm or less under a temperature condition of −196 to 30 ° C. The granules are prepared by injecting together with a binder into a co-rotating type twin screw extruder equipped with a conveying screw and kneading blocks under the following conditions. It provides a method for producing granules using ginseng and red yeast soup.

Screw rotation speed: 150 to 250 rpm

Barrel pressure: 50 to 150 bar

Clearance between screw and barrel: 0.1 ~ 0.3 mm

Barrel heating temperature: 100 ~ 200 ℃

In addition, according to the fifth aspect of the present invention, a conveying screw and kneading blocks are provided with a ginseng powder crushed to a diameter of 10 μm or less under a temperature condition of −196 to 30 ° C. under the following conditions. Injecting into a co-rotating type twin screw extruder, and extruding to form a core;

Screw rotation speed: 150 to 250 rpm

Barrel pressure: 50 to 150 bar

Clearance between screw and barrel: 0.1 ~ 0.3 mm

Barrel heating temperature: 100 ~ 200 ℃

It provides a method for producing granules using ginseng and red ginseng comprising the; coating the surface of the molded core with red ginseng powder crushed to a diameter of 10 ㎛ or less at a temperature of -196 ~ 30 ℃ do.

According to a sixth aspect of the present invention, a conveying screw and kneading blocks are provided with red yeast powder crushed to a diameter of 10 μm or less under a temperature condition of −196 to 30 ° C. under the following conditions. Injecting into a co-rotating type twin screw extruder, and extruding to form a core;

Screw rotation speed: 150 to 250 rpm

Barrel pressure: 50 to 150 bar

Clearance between screw and barrel: 0.1 ~ 0.3 mm

Barrel heating temperature: 100 ~ 200 ℃

Providing a method for producing granules using ginseng and red ginseng, comprising the step of coating the surface of the molded core with ginseng powder crushed to a diameter of 10 μm or less under a temperature condition of -196 to 30 ° C. do.

Hereinafter, the content of the present invention will be described in more detail below.

The first aspect of the present invention relates to a method for producing granules by mixing ginseng powder and red ginseng powder pulverized to a diameter of 10 μm or less under a temperature condition of −196 to 30 ° C., and the second and third aspects of the present invention. The form is made of ginseng powder or red yeast powder crushed to a diameter of 10 μm or less at a temperature of -196 to 30 ° C., one of which forms a core, and the other of which forms the core surface to coat the core surface. It relates to a manufacturing method.

In the first to sixth embodiments of the present invention, ginseng powder or red ginseng powder, which is crushed to have a diameter of 10 μm or less under a temperature condition of -196 to 30 ° C., is used. It is easy to form a core using water as a binder.

On the other hand, the ginseng powder crushed to a diameter of 10 ㎛ or less at a temperature of -196 ~ 30 ℃ is extracted new ginsenosides compared to the general crude crushing method, the specific ginsenosides are characterized by high content have.

On the other hand, in the first to sixth aspect of the present invention, as long as the binder can be used as an edible material as long as it can bind the powder to each other, water can be easily used as an example.

On the other hand, in the first to sixth aspects of the present invention, after the granules are produced, the primary coating (in the case of the first and fourth embodiments of the present invention) and the secondary coating (preferably the present invention) are preferably chocolate or sugar. Of the second, third, fifth and sixth aspects of the invention). When coated with sugar or chocolate, it can be sweetened to make it easier to drink, and sugar can be used to give a glossy surface. This type of coating may be repeatedly performed, and the coating material during coating may be used after preparing various bioactive substances in liquid form in addition to chocolate or sugar.

On the other hand, the fourth aspect of the present invention relates to a method for producing granules by mixing and extruding ginseng powder and red yeast powder pulverized to a diameter of 10 μm or less under a temperature condition of -196 to 30 ° C. The fifth and sixth forms were extruded using either ginseng powder or red ginseng powder crushed to have a diameter of 10 μm or less at a temperature of -196 to 30 ° C., and then a core was formed, and the other was the core surface. The present invention relates to a method for producing granules by coating a cobalt, and to operating conditions of a co-rotating type twin screw extruder equipped with a conveying screw and kneading blocks. Silver rotation speed of a screw: 150-250 rpm, pressure of a barrel: 50-150 bar, clearance of a screw and a barrel: 0.1-0.3 mm, heating temperature of a barrel: 100-200 degreeC.

Extrusion has recently been studied as one of the technologies that can process ginseng economically. The extruder rotates a screw installed in a barrel to heat, mix, separate, compress and arrange the fibers in one process. Ginseng can be processed within a short time as a continuous production technology that can be expanded and molded.

The pressure applied during extrusion and the rotational speed of the screw generate a strong shear force to dissolve the cell wall of ginseng to easily elute the active ingredient present in the cell wall, and finely crush insoluble fiber tissue to increase water solubility.

The extrusion machine used in the present invention is a co-rotating type twin screw extruder equipped with a conveying screw and kneading blocks, and includes two rotating shafts in the barrel. And a pair of conveying screws are meshed with each of the rotational shafts, and a pair of kneading blocks are provided with the rotational shafts.

On the other hand, preferably, the conveying screw and the kneading blocks may be repeatedly provided with the conveying screw and the kneading blocks in accordance with the transfer flow.

Coaxial biaxial conveying screw plays a role of mass transfer of material, intermeshing and self cleaning, especially in order to give physical change of material during transfer of ginseng powder. Changes can lead to increased solubility of components such as elution and extraction through cell wall destruction. In addition, the kneading block enables the mixing and kneading of the material, and in particular, the change in the angle of the kneading block increases the mechanical resistance of the conveying screw, such as an increase in the filling degree of the conveying screw, due to a change in the transfer resistance of the material, thereby increasing the physical change of the material, that is, an effective cell wall. It can bring about increased solubility of components such as elution and extraction through destruction.

At this time, more preferably, the conveying screw is provided with the extrusion molding machine to sequentially decrease the blade angle according to the conveying flow, and the kneading block that the blade angle is sequentially increased according to the conveying flow is preferably provided to the extrusion molding machine, This is because the shear force can be gradually given to the ginseng powder.

On the other hand, in the first to sixth aspects of the present invention, the ginseng powder preferably has an average particle size of 50% by weight in the total forest powder of 1.3 µm or less.

On the other hand, in the first to sixth aspects of the present invention, the temperature condition of -196 to 30 ° C is preferably achieved by mixing a member capable of lowering the temperature to -196 to 30 ° C together with ginseng or red ginseng. For example, the member that can lower the temperature to -196 ~ 30 ℃ may be used as dry ice or liquid nitrogen as an example.

Since the granules using ginseng and red ginseng prepared by the present invention use those prepared in the form of fine powder, the water solubility in water is increased, making the granules easy to prepare, and also increasing the absorption rate in the small intestine when ingested. Can be.

In addition, the powder of ginseng or red yeast rice further subjected to the extrusion process exhibits the effect of further crushing the tissue to further increase the water solubility.

Hereinafter, the content of the present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited only to the following examples.

Production Example  1: Preparation of Ginseng Fine Powder

In the preparation of powder, ginseng was subjected to coarse and fine crushing under the assumption that particle size would affect water solubility. Rough crushing (G.R.rough) had a diameter of the ginseng powder in the range of 10 ~ 1000 ㎛ (see Figure 1), the fine crushed showed a range of 10 ㎛ or less (see Figures 2 to 5).

On the other hand, in the case of fine crushing, the crushing process was performed by variously controlling the temperature conditions, which was extracted at 30 ° C. without using a coolant, the grinding cylinder was cooled to -20 ° C., and dry ice was 1 to 1 weight ratio. The mixture was pulverized, and liquid nitrogen was mixed with crushed ginseng in a 1 to 1 weight ratio and crushed. (See Figures 2-5)

Water solubility was measured for the samples prepared as above.

In the case of the coarsely crushed powder, the particles could not be dispersed and aggregated with each other. However, in the case of the finely crushed powder, the particles were uniformly dispersed in the aqueous solution regardless of the temperature conditions.

Production Example  2: Red yeast rice  Preparation of Fine Powder

In this preparation example, red ginseng made by fermenting red ginseng bacterium of Monascus in rice was subjected to coarse and fine shredding in the same manner as the ginseng. Crude crushing had a diameter of red yeast powder in the range of 10-1000 μm (not shown), and fine crushing showed a range of 10 μm or less (not shown).

On the other hand, during the fine crushing, as in ginseng, the temperature was controlled by variously controlling the crushing process, extracting at 30 ℃ without using a refrigerant, cooling the grinding cylinder to -20 ℃, dry ice and red rice 1 The mixture was pulverized by mixing in a weight ratio of 1 to 1, and the liquid nitrogen was pulverized by being mixed and pulverized in a 1 to 1 weight ratio with red yeast rice.

Water solubility was measured for the samples prepared as above.

As in ginseng of Preparation Example 1, when the coarsely crushed powder was added to water, the particles could not be dispersed and aggregated together. However, in the case of the finely crushed powder, the particles were uniformly dispersed in the aqueous solution regardless of the temperature conditions. It was confirmed to be dispersed.

Experimental Example  1: at temperature conditions of -196 to 30 ° C diameter  Investigation of the characteristics of ginseng crushed to less than 10 ㎛

Ginsenoside, an active ingredient of ginseng, is known to show various effects depending on the type. Ginsenosides with sugars are ginsenosides that are desugared by heat treatment or enzyme action and acid treatment during ginseng processing. Switch to the side.

In the present experimental example, it was observed how the composition change and the elution amount of the active ingredient changed when the fine powder of 12 ginsenosides of ginseng.

Rough crushing (G.R.rough) had a diameter of the ginseng powder ranged from 10 to 1000 ㎛ (see Figure 1), and fine crushed showed a range of 10 ㎛ or less (see Figures 2 to 5).

On the other hand, when finely crushed, the crushing process was performed by variously controlling the temperature conditions, which was extracted at 30 ° C without using a refrigerant (GRA), the grinding cylinder was cooled to -20 ° C (GRE), and dry ice. Ginseng was mixed and ground in a 1 to 1 weight ratio (GRI), liquid nitrogen was mixed and ground into a powder (GRM) in a 1 to 1 weight ratio and crushed. (See Figures 2-5)

After crushing, 2 g of each sample was taken, followed by solvent extraction using sterile distilled water at a temperature of 37 ° C. similar to human body temperature when ingested (Table 1 below) and HCl (pH = 2 ~) 2.5) When extracted with an aqueous solution (Table 2), divided into ethyl acetate solvent each, and then the solvent layer was removed, and fractionated using saturated butanol. The solvent in the butanol layer was evaporated under reduced pressure, and the remaining ginsenosides (Re, Rg1, Rf, Rb1, Rc, Rg2, Rh1, Rb2, Rb3, Rd, Rg3, Rh2) were analyzed by HPLC. Each was quantified and compared.

The results were as in Table 1 and Table 2.

Contents of 12 Ginsenosides of Water Extracts by Refrigerant during Crude and Microcrushing of Ginseng (37 ℃) content ( mg / g powder ) Ginsenoside G.R. rough .G.R.A G.R.E G.R.I G.R.M Re 1.527 5.574 5.332 6.987 5.631 Rg1 1.956 3.099 3.307 3.937 3.192 Rf 0.434 1.022 1.040 1.372 1.057 Rb1 0.841 3.316 3.518 4.545 3.844 Rc 0.437 2.328 2.383 3.828 2.649 Rg2 0.072 0.430 0.263 0.959 0.291 Rh1 0.025 0.000 0.374 0.369 0.454 Rb2 0.294 2.776 1.861 2.459 2.051 Rb3 0.118 2.577 1.565 1.486 1.673 Rd 0.695 1.040 0.712 0.893 0.723 Rg3 0.207 0.350 0.271 0.360 0.330 Rh2 0.000 0.008 0.000 0.031 0.000

The contents of 12 ginsenosides of acid-treated extracts by refrigerant (37 ℃) during the fine crushing of ginseng. content ( mg / g powder ) Ginsenoside G.R. rough G.R.A G.R.E G.R.I G.R.M Re 0.014 0.220 0.358 0.223 0.261 Rg1 0.033 0.189 0.204 0.200 0.221 Rf 0.373 0.615 0.732 0.804 0.817 Rb1 0.230 1.430 1.457 1.667 1.723 Rc 0.000 0.794 0.440 0.861 0.870 Rg2 0.266 0.475 0.645 0.761 0.780 Rh1 0.257 0.530 0.715 0.796 0.797 Rb2 0.000 0.000 0.000 0.000 0.000 Rb3 0.000 0.471 0.714 0.801 0.846 Rd 0.171 0.727 0.822 0.872 0.937 Rg3 0.000 0.211 0.208 0.217 0.226 Rh2 0.011 0.234 0.371 0.528 0.614

As a result of the experiment, the fine crushed powder (particle size of 10 μm or less in diameter, the average size of 50% by weight particles is 0.8 to 0.9 μm in diameter) and the coarse crushed powder (particle size in the range of 10 to 1000 μm in diameter, 50 wt% The average size of the particle size was about 236 μm in diameter), and most ginsenosides measured in the ginsenoside comparison of the water extracts having a diameter of about 236 μm exhibited a remarkably high content in the finely divided powder.

On the other hand, the content of ginsenosides of the water extract for each refrigerant use showed the highest elution result in the preparation of fine powder using dry ice. In particular, Re, Rg1, Rf, Rb1, Rc, Rg2, Rg3, Rh2 showed the highest elution amount in the refrigerant (G.R.I) using dry ice among the treatment groups.

Rh1 showed the highest leaching amount in the refrigerant (G.R.M) using liquid nitrogen. Rb2, Rb3 and Rd showed the highest content in (G.R.A) fine powder without refrigerant.

On the other hand, in the acid treatment group, the ginsenoside Rh2 component was increased in the crushing using dry ice and liquid nitrogen, which was more than 50 times higher than the amount of Rh2 generated after the acid treatment in the rough fracture.

On the other hand, the ultra fine pulverized ginseng powder is digested by the strong acid (pH = 2) of gastric juice when ingested in humans, and among the 12 ginsenosides measured in the present invention, the amount of all ginsenosides except Rb2 is added to the crude crushing. It was higher than that.

Thus, by using the present invention, it can be concluded that ginseng powder having a high elution amount of a specific ginsenoside may be obtained, which may ultimately be used for the production of a functional ginseng processed product. Was prepared.

Example  1: ginseng fine powder and Red yeast rice  Preparation of Granules Using Fine Powder

After mixing the ginseng powder crushed to a diameter of 10 μm or less at a temperature of 30 ° C. and the red chrysanthemum powder pulverized to a diameter of 10 μm or less at a temperature of 30 ° C., water is added to the binder and a known method is used. Granules were prepared to have a diameter of about 1-10 mm.

Example 2 Preparation of Granules with Red Ginseng Powder Coated on the Surface of Ginseng

Water was added to the ginseng powder crushed to a diameter of 10 μm or less at a temperature of 30 ° C. to form a core having a diameter of about 1 to 10 mm.

Example 3: Preparation of granules coated with ginseng powder on the surface using red yeast rice as a core

A core of about 1 to 10 mm in diameter was formed by adding water to the red chrysanthemum powder crushed to a diameter of 10 μm or less at a temperature of 30 ° C. as a binder.

After molding, the crushed ginseng powder was dissolved in water at a temperature of 30 ° C. so as to have a diameter of 10 μm or less, and then coated on the surface of the core by pan coating to prepare granules.

Example  4: ginseng fine powder and Red yeast rice  After the fine powder is mixed, the granules are manufactured by extrusion molding.

Ginseng powder crushed to a diameter of 10 μm or less at a temperature of 30 ° C. and red chrysanthemum powder pulverized to a diameter of 10 μm or less at a temperature of 30 ° C. were mixed, followed by a conveying screw and a conveying screw under the following conditions. A co-rotating type twin screw extruder equipped with kneading blocks was added to the co-rotating type twin screw extruder, and then extruded to form granules.

Screw rotation speed: 200 rpm

Barrel pressure: 100 bar

Clearance between screw and barrel: 0.2 mm

Barrel heating temperature: 160 ° C

Example  5: Extruded ginseng as a core Red yeast rice  Preparation of Powder Coated Granules

Co-rotating type co-rotating type with ginseng powder crushed to below 10 ㎛ diameter at 30 ℃ and equipped with conveying screw and kneading blocks under the following conditions Into the twin screw extruder) and water, and then extruded to form a core.

Screw rotation speed: 200 rpm

Barrel pressure: 100 bar

Clearance between screw and barrel: 0.2 mm

Barrel heating temperature: 160 ° C

After the molding, the surface of the core was melted in water to crush the red chrysanthemum powder so as to have a diameter of 10 μm or less at a temperature of 30 ° C. and coated on the surface of the core to prepare granules.

Example 6: Preparation of granules coated with ginseng powder on the surface using red yeast rice subjected to extrusion molding as a core

A co-rotating type co-rotating type with a conveying screw and kneading blocks for crushed red yeast powder to a diameter of 10 μm at a temperature of 30 ° C. under the following conditions Into the twin screw extruder) and water, and then extruded to form a core.

Screw rotation speed: 200 rpm

Barrel pressure: 100 bar

Clearance between screw and barrel: 0.2 mm

Barrel heating temperature: 160 ° C

After molding, the surface of the core was crushed ginseng powder so as to have a diameter of 10 μm or less at a temperature of 30 ° C. in water and then coated on the core surface to prepare granules.

1 is a particle size analysis result of the rough crushed (G.R.rough) of ginseng.

Figure 2 is a particle size analysis of micro-crushed (G.R.A) of ginseng uncooled (room temperature).

3 is a particle size analysis result of the fine crushing (G.R.E) of ginseng cooling the grinding cylinder to -20 ℃.

4 is a particle size analysis result of fine crushed (G.R.I) cooled by adding dry ice to ginseng.

5 is a particle size analysis result of fine crushed (G.R.M) by adding liquid nitrogen to ginseng.

Claims (14)

delete delete delete A ginseng powder crushed to have a diameter of 10 μm or less at a temperature condition of -196 to 30 ° C. and a red yeast powder crushed to have a diameter of 10 μm or less at a temperature condition of -196 to 30 ° C., a conveying screw under the following conditions. And co-rotating type twin screw extruder equipped with kneading blocks and kneading blocks, followed by extrusion to produce granules. Method for producing granules. Screw rotation speed: 150 to 250 rpm Barrel pressure: 50 to 150 bar Clearance between screw and barrel: 0.1 ~ 0.3 mm Barrel heating temperature: 100 ~ 200 ℃ A co-rotating twin screw extruder equipped with a conveying screw and kneading blocks under the following conditions for ginseng powder pulverized to a diameter of 10 μm or less at a temperature of -196 to 30 ° C. (co -rotating type twin screw extruder) and then with the binder, extruding to form a core; Screw rotation speed: 150 to 250 rpm Barrel pressure: 50 to 150 bar Clearance between screw and barrel: 0.1 ~ 0.3 mm Barrel heating temperature: 100 ~ 200 ℃ And coating the surface of the molded core with red ginseng powder crushed to have a diameter of 10 μm or less under a temperature condition of -196 to 30 ° C .; granules using ginseng and red ginseng, characterized in that it comprises a. Co-rotating twin screw extruder equipped with a conveying screw and kneading blocks under crushed red yeast powder at a temperature of -196 ~ 30 ℃ with a diameter of 10 µm -rotating type twin screw extruder) and then with the binder, extruding to form a core; Screw rotation speed: 150 to 250 rpm Barrel pressure: 50 to 150 bar Clearance between screw and barrel: 0.1 ~ 0.3 mm Barrel heating temperature: 100 ~ 200 ℃ Coating the surface of the molded core with ginseng powder crushed to a diameter of 10 ㎛ or less at a temperature of -196 ~ 30 ℃; method of producing granules using ginseng and red ginseng. The method according to any one of claims 4 to 6, Ginseng powder, A method for producing granules using ginseng and red ginseng, characterized in that the average particle size of 50% by weight of the total ginseng powder is 1.3 ㎛ or less. The method according to any one of claims 4 to 6, -196 ~ 30 ℃ temperature conditions, Method for producing granules using ginseng and red ginseng, characterized in that achieved by mixing a member capable of lowering the temperature to -196 ~ 30 ℃ with ginseng or red ginseng. The method of claim 8, The member that can lower the temperature to -196 ~ 30 ℃, Method for producing granules using ginseng and red yeast, characterized in that dry ice or liquid nitrogen. The method according to any one of claims 4 to 6, The binder, Method for producing granules using ginseng and red yeast soup, characterized in that water. The method of claim 4, wherein After the granules are manufactured, Method of producing granules using ginseng and red yeast, characterized in that the coating with chocolate or sugar. The method according to claim 5 or 6, After coating, Method for producing granules using ginseng and red yeast soup, characterized in that the second coating with chocolate or sugar. The method according to any one of claims 4 to 6, Conveying screws and kneading blocks Conveying screw (kneading block) and a kneading block (kneading blocks) is a method for producing granules using ginseng and red yeast, characterized in that the repetition is provided sequentially. The method of claim 13, Conveying screw is provided in the extrusion molding machine to sequentially reduce the blade angle according to the feed flow, A method for producing granules using ginseng and red yeast soup, characterized in that the kneading block having a blade angle which is sequentially increased according to the transport flow is provided in the extrusion molding machine.

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