KR100964507B1 - Ionic or molecular channel, sensor and antibacterial agent comprising metal-organic polyhedra - Google Patents

Abstract

FIELD OF THE INVENTION The present invention relates to ion channels or molecular channels, sensors and antimicrobial compositions comprising metal-organic polyhedron materials, specifically using a structure composed of metal-organic polyhedrons having a three-dimensional structure to selectively select specific ions or molecules. An ion or molecular channel available for passage, and a sensor comprising the same.

Description

Ionic or molecular channel, sensor and antibacterial agent comprising metal-organic polyhedra}

FIELD OF THE INVENTION The present invention relates to ion or molecular channels, sensors and antimicrobial compositions comprising metal-organic polyhedron materials. Specifically, the selective passage of specific ions or molecules using structures consisting of metal-organic polyhedrons having a three-dimensional structure It relates to ionic or molecular channels, sensors and antimicrobial compositions that can be used for.

In general, an ion channel or a molecular channel is inserted into a lipid membrane in vivo to pass ions or molecules in and out of it.

The functions of living bodies are often regulated by electrical signals, and ion molecular channels regulate these electrical signals, which in turn regulate many biological functions such as nerve signal transmission and muscle contraction. The ion channel is composed of hydrophobic amino acids on the outside so that the ion channel can be inserted into the lipid membrane, and the inside is composed of hydrophilic amino acids to allow ions to pass therethrough.

Many artificial ion channels have been developed to mimic these natural ion channels. Most of these artificial ion channels are formed by self-assembly, in which a large ring molecule or a plurality of units form a cylindrical shape, and in the case where the size of the pupil formed inside such a structure is large, not only ions but also specific molecules inside the lipid membrane. And outside, in which case it is called a molecular channel. These ion channels and molecular channels not only help the research on the natural ion channels, but also have been applied to the development of drugs, antibacterial agents, sensors, and the like.

Since the first artificial ion channels made of cyclodextrins have been published, many artificial ions or molecular channels have been developed, mainly using organic synthesis such as crown ethers, kalixarene and peptides. However, these organic molecules have a disadvantage in that the synthesis is complicated and not easily modified.

Therefore, there is a need for a new structure ion channel or molecular channel that can be easily synthesized and modified.

The first problem to be solved by the present invention is to provide an ion channel or a molecular channel for passing ions or molecules using a metal-organic polyhedron material that can be easily synthesized and modified.

A second object of the present invention is to provide a sensor for detecting and separating specific molecules or ions using the ion channel or molecular channel.

It is a third object of the present invention to provide an antimicrobial composition comprising the metal-organic polyhedron material.

In order to achieve the first object, the present invention,

Provided are ion channels or molecular channels comprising a metal-organic polyhedron material of Formula 1:

<Formula 1>

In the above formula,

M represents a metal ion,

L ₁ , L ₂ , L ₃ , L ₄ , L ₅ and L ₆ each independently represent a monodentate ligand or a multidentate ligand,

n represents an integer of 3 or more.

According to one embodiment of the present invention, M is Mg ²⁺ , Ca ²⁺ , Sr ²⁺ , Ba ²⁺ , Sc ³⁺ , Y ³⁺ , Ti ⁴⁺ , Zr ⁴⁺ , Hf ⁴⁺ , V ^{4 +} , V ³⁺ , V ²⁺ , Nb ³⁺ , Ta ³⁺ , Cr ³⁺ , Mo ³⁺ , W ³⁺ , Mn ³⁺ , Mn ²⁺ , Re ³⁺ , Re ²⁺ , Fe ³⁺ , Fe ²⁺ , Ru ³⁺ , Ru ²⁺ , Os ³⁺ , Os ²⁺ , Co ³⁺ , Co ²⁺ , Rh ²⁺ , Rh ⁺ , Ir ²⁺ , Ir ⁺ , Ni ²⁺ , Ni ⁺ , Pd ²⁺ , Pd ⁺ , Pt ²⁺ , Pt ⁺ , Cu ²⁺ , Cu ⁺ , Ag ⁺ , Au ⁺ , Zn ²⁺ , Cd ²⁺ , Hg ²⁺ , Al ³⁺ , Ga ³⁺ , In ³⁺ , Tl ³⁺ , Si ⁴⁺ , Si ²⁺ , Ge ⁴⁺ , Ge ²⁺ , Sn ⁴⁺ , Sn ²⁺ , Pb ⁴⁺ , Pb ²⁺ , As ⁵⁺ , As ³⁺ , As ⁺ , Sb ⁵⁺ And metal ions selected from the group consisting of Sb ³⁺ , Sb ⁺ , Bi ⁵⁺ , Bi ³⁺ and Bi ⁺ .

According to one embodiment of the present invention, examples of the monodentate ligand include amine compounds, halogen ions, alcohol compounds, pyridine compounds, furan compounds, H ₂ O, SCN ⁻ , CN ⁻ , and the like.

According to one embodiment of the present invention, as the multidentate ligand, a trimethate ligand, a terephthalate ligand, a 4,4'-bipyridine ligand, a 2,6-naphthalenedicarboxylate ligand, a pyrazine ligand And benzene dicarboxylate ligands, pyridine dicarboxylate ligands, biphenyl dicarboxylate ligands, triphenylbenzene ligands, or triphenyldicarboxylate catalysts.

According to one embodiment of the present invention, n represents a number from 3 to 10,000.

In order to achieve the second object of the present invention,

It provides a sensor comprising the ion channel or molecular channel.

In order to achieve the third object, the present invention,

It provides an antimicrobial composition comprising a metal-organic polyhedron material of Formula 1.

The ion channel or the molecular channel according to the present invention can be easily prepared using the metal-organic polyhedron material obtained through a method of mixing a metal and an organic ligand without going through a difficult synthesis process, and the metal channel By changing the type of ligand used in the organic polyhedron material, its properties can be easily adjusted.

In the present invention, the sensor is capable of detecting and separating various kinds of molecules or ions since the metal-organic polyhedron material selectively passes molecules or ions according to the size of the pupil.

In addition, since the metal-organic polyhedron material has good antibacterial ability against bacteria, it can be used as an antibacterial agent.

In the ion channel or molecular channel using the metal-organic polyhedron material according to the present invention, the metal-organic polyhedron material is inserted into the lipid membrane to allow ions or molecules to pass through the pupil of the polyhedron material.

In addition, since the metal-organic polyhedron material can pass specific molecules or ions according to the size of the pupil formed, the metal-organic polyhedron material can be used as a sensor of molecules or ions, and can be used as an antimicrobial agent using the property of destroying the lipid membrane of bacteria.

The metal-organic polyhedron material used in the present invention is a material represented by the following Chemical Formula 1, and has a three-dimensional skeletal structure including a cavity of a predetermined size, and selectively passes ions or molecules through the cavity.

Provided are ion channels comprising a metal-organic polyhedron material of Formula 1:

<Formula 1>

In the above formula,

M represents a metal ion,

L ₁ , L ₂ , L ₃ , L ₄ , L ₅ and L ₆ each independently represent a monodentate ligand or a multidentate ligand,

n represents an integer of 3 to 10,000.

As for n, 10-1,000 are further more preferable, and 10-100 are still more preferable.

In the present invention, the metal-organic polyhedron material represented by Chemical Formula 1 and a method of manufacturing the same are disclosed in the literature (Korean Patent Publication No. 2006-0126692), which is incorporated herein by reference.

The document discloses a metal-organic polyhedron material which is easily formed even at room temperature only by mixing a simple organic ligand and a metal, and which can easily modify the overall structure and properties by simple modification of the organic ligand. Thus, these metal-organic polyhedron materials are used as the passage of artificial ions or molecules according to the invention.

In the structure of the metal-organic polyhedron material of Formula 1, M represents a central metal ion, for example Mg ²⁺ , Ca ²⁺ , Sr ²⁺ , Ba ²⁺ , Sc ³⁺ , Y ³⁺ , Ti ^{4 +} , Zr ⁴⁺ , Hf ⁴⁺ , V ⁴⁺ , V ³⁺ , V ²⁺ , Nb ³⁺ , Ta ³⁺ , Cr ³⁺ , Mo ³⁺ , W ³⁺ , Mn ³⁺ , Mn ²⁺ , Re ³⁺ , Re ²⁺ , Fe ³⁺ , Fe ²⁺ , Ru ³⁺ , Ru ²⁺ , Os ³⁺ , Os ²⁺ , Co ³⁺ , Co ²⁺ , Rh ²⁺ , Rh ⁺ , Ir ²⁺ , Ir ⁺ , Ni ²⁺ , Ni ⁺ , Pd ²⁺ , Pd ⁺ , Pt ²⁺ , Pt ⁺ , Cu ²⁺ , Cu ⁺ , Ag ⁺ , Au ⁺ , Zn ²⁺ , Cd ²⁺ , Hg ²⁺ , Al ³⁺ , Ga ³⁺ , In ³⁺ , Tl ³⁺ , Si ⁴⁺ , Si ²⁺ , Ge ⁴⁺ , Ge ²⁺ , Sn ⁴⁺ , Sn ²⁺ , Pb ⁴⁺ , Pb ²⁺ , As ⁵ Metal ions selected from the group consisting of ⁺ , As ³⁺ , As ⁺ , Sb ⁵⁺ , Sb ³⁺ , Sb ⁺ , Bi ⁵⁺ , Bi ^3+, and Bi ⁺ are not limited thereto.

In the structure of the metal-organic polyhedron material of Chemical Formula 1, L ₁ , L ₂ , L ₃ , L ₄ , L _5, and L ₆ are ligands covalently or ionically bonded to the central metal, and are monodentate ligands or multidentate ligands. It is possible to use multidentate ligands. Herein, a monodentate ligand means a ligand which one ligand binds to one central metal ion, and means a ligand that cannot bind to another neighboring metal ion.

The multidentate ligand refers to a ligand having several functional groups capable of simultaneously forming covalent bonds or ionic bonds to two or more central metal ions or neighboring ligands, and by combining such multidentate ligands, the metal-organic polyhedron The material forms the pupil structure by forming a network structure.

When the pupil is formed through the multidentate ligand, the central metal ion does not have to form a coordination bond only with the multidentate ligand, and may also be bonded to a neighboring single site ligand if necessary. In other words, in the case of containing a multidentate ligand as described above, the single-site ligand is further included if necessary.

As such a single-site ligand, all ligands used in general coordination compounds can be selected without any limitation, and a ligand including nitrogen, oxygen, sulfur, phosphorus, arsenic, etc., in which an auxiliary electron pair exists can be used. For example, an amine-based compound, a halogen ion, an alcohol-based compounds, pyridine-based compound, a furan compound, H ₂ O, SCN ^- and the like may be used ^-, CN. The amine compound is a form in which three substituents are bonded to a nitrogen atom, and as such substituents, hydrogen or a substituted or unsubstituted alkyl group having 1 to 20 carbon atoms, a substituted or unsubstituted aryl group having 6 to 30 carbon atoms, substituted or unsubstituted An alkylaryl group having 6 to 30 ring carbon atoms can be used. The alcoholic compound has an R-OH form, and as R, a substituted or unsubstituted alkyl group having 1 to 20 carbon atoms, a substituted or unsubstituted aryl group having 6 to 30 carbon atoms, a substituted or unsubstituted alkyl group having 6 to 30 carbon atoms An aryl group can be used.

However, single-site ligands do not have only one functional group, and in the case of forming a chelate ring as described above, it is also possible to use a multi-site ligand. That is, even if a multi-digit ligand such as 2, 3, 4, etc., if the metal atoms or ions can form a network through another ligand, their use is not limited.

Such a metal according to the invention the organic polyhedra material shall include polydentate ligands at least one, such polydentate ligands include CO ₂ to the sub-electron pairs exist to coordinate bond with the metal atom or ^ion-, CS ₂ ^{- _{, NO 2 -, SO 3 -}} , and a single or a hydrocarbon reactor containing a plurality of atoms are a combination of the reactor is replaced by a hydrocarbon or a hetero atom. Specific examples of such multidentate ligands include, for example, trimethate ligand of Formula 2, terephthalate ligand of Formula 3, 4,4'-bipyridine ligand of Formula 4, and 2,6-naphthalene of Formula 5 Dicarboxylate ligands, and pyrazine based formula (6), benzenedicarboxylate based ligand (7), pyridine dicarboxylate based ligand (8). Biphenyl dicarboxylate based formula (11), triphenylbenzene based ligand (12), triphenyl dicarboxylate (13), etc.

<Formula 2>

<Formula 3>

<Formula 4>

<Formula 5>

<Formula 6>

<Formula 7>

<Formula 8>

<Formula 9>

<Formula 10>

<Formula 11>

Wherein R ₁ to R ₇₁ are each independently a hydrogen atom, a halogen atom, a hydroxy group, a substituted or unsubstituted C1-20 alkyl group, a substituted or unsubstituted C1-20 alkoxy group, substituted or unsubstituted A substituted or unsubstituted alkenyl group having 2 to 20 carbon atoms, a substituted or unsubstituted aryl group having 6 to 30 carbon atoms, a substituted or unsubstituted alkylaryl group having 6 to 30 carbon atoms, substituted or unsubstituted Unsubstituted C6-C30 arylamine group, substituted or unsubstituted C6-C30 aryloxy group, substituted or unsubstituted C2-C30 heteroaryl group, or substituted or unsubstituted C2-C30 Heteroaryloxy group. Several examples of such multidentate ligands are described in more detail in Christoph Janiak, Dalton Trans. , 2003, p2781-2804; and Stuart L. James, Chem. Soc. Rev. , 2003, 32, 276-288. And incorporated herein by reference.

The metal-organic polyhedron material having the structure of Formula 1 as described above may have a crystalline structure, and have a structure in which the cavities are arranged regularly. The size of the cavity can be measured using a method such as MS modeling, for example, it is preferable to have a range of 0.5 to 100mm 3. This pupil size corresponds to a value sufficient for ions or molecules to pass through. That is, the metal-organic polyhedron material of the present invention can pass ions or molecules, and the type of molecules that can pass is determined by the size of the pupil. Therefore, using these characteristics, it is easy to manufacture a sensor that can be used for the detection of specific ions or molecules.

As mentioned above, the selectivity of the metal-organic polyhedron material according to the present invention can be described as the size of the molecule passing through the pores of the metal-organic polyhedron material. Metal-organic polyhedron materials are sufficient to pass ions and the like, but because they have a limited size of pores, not all molecules can pass through them, and generally only molecules having a size smaller than the size of the pores are allowed to pass.

Also, if the pupil inlet of the metal-organic polyhedron material contains a specific functional group, only molecules that can interact with this functional group are allowed to pass through. Methyl viologen and DPX, for example, are almost the same in width, 6.6 kW, but because of their longer DPX, they are far less likely to approach the inlet of the metal-organic polyhedron. Therefore, in the method of the present invention, it is possible to selectively detect even molecules having similar sizes.

The ion or molecular channel according to the present invention can be prepared simply by inserting the metal-organic polyhedron material represented by Chemical Formula 1 into the lipid membrane, as shown in FIG. 6, and the polyhedral crystal inserted into the lipid membrane. It allows ions or molecules to pass through the cavity of the material.

Examples of the ions that can pass through the ion channel include group 1 alkali metal ions, group 2 alkaline earth metal ions, group 17 halogen ions, transition metal ions, or ions of transition metal oxides, and may pass through the molecular channel. As a molecule, C _l H _m N _n O _o S _p P _q ^r (wherein l, m, n, o, p, q are each independently an integer of 0 to 100, and r represents a charge amount of -5 to +5). Molecule | numerator which can be represented by the above-mentioned.

On the other hand, it can be seen that the metal-organic polyhedron material of Chemical Formula 1 has antimicrobial properties from its ability to be inserted into a lipid membrane and destroy the membrane. This antimicrobial property is made possible by breaking the membrane while the metal-organic polyhedron represented by Formula 1 is in contact with the cell membrane of bacteria and the polyhedral crystal is inserted into the cell membrane by hydrophobic interaction.

Hereinafter, the present invention will be described with reference to the following examples, but the present invention is not limited only to the following examples.

Example 1 Passage of Ions and Molecules

J. Am. Chem. Soc. 2006, 128, 8398-8399. The metal-organic polyhedron material MOP-18 was synthesized.

The structural formula of the MOP-18 is Cu ₂₄ (5-OC ₁₂ H ₂₅ - m BDC) ₂₄ , Water or other solvents can be coordinated here. In the manufacturing process, Cu (CH ₃ CO ₂ ) ₂ OH H ₂ O and 5-dodecoxybenzene-1,3-dicarboxylic acid were 1: 1 in DMF. Mixing in proportions formed blue crystals, which were synthesized by filtration.

The thin figure of FIG. 1 is a figure which shows the three-dimensional crystal structure obtained by the X-ray crystal structure analysis method with respect to said MOP-18. In the three-dimensional crystal structure, the part shown in yellow represents a copper metal, the part connected with gray spheres represents a carbon atom, and red represents an oxygen atom. In addition, purple spheres in Figs. 1 and 3 indicate the size of the pupil. In Figure 1, it can be seen that the polyhedral molecules formed from metal and organic ligands are regularly arranged in cavities. The metal-organic polyhedron material, when calculated using MS modeling, has a pore size of 3.8 kPa (FIG. 1, B) or 6.6 kPa (FIG. 1, C). This size corresponds to a size sufficient for ions or molecules to pass through.

Warner Instruments' Planar Lipid Bilayer Workstation was used as a measuring instrument for the ion channel. This device is a device capable of measuring the current flowing through the hole of about 200 μm size of the cup by filling the electrolyte inside and outside the cup as shown in FIG.

In this example, 1 M KCl was filled in and out of the cup, and then a membrane was formed by applying egg PC (1 mg / mL in n-decane), a kind of lipid, to the hole of the cup. At this time, since the hole is blocked by the lipid membrane, even if the potential difference is given, the current is zero. Subsequently, 1% by weight of MOP-18 is mixed with Egg PC (1mg / mL in n-decane) and applied to the pores so that MOP-18 is inserted into the membrane and current flows, which appears as a stepped current. This flow of current is shown in Figures 2a and 2b.

2A and 2B are graphs showing the current plots for K ions of metal-organic polyhedron materials measured in Egg PC membranes. In Figs. 2A and 2B, the x-axis (a) represents time (sec) and the y-axis represents current value (pA), and (b) shows the result of this change in current value in accordance with the change in voltage. 2A and 2B, the conductivity value for K + ions of the metal-organic polyhedron material is 36 pS. The conductivity values show improved results when compared to artificial ion channels consisting of known single molecules.

Therefore, it can be seen that the MOP-18 can be used as a passage of ions in the lipid membrane.

Example 2: Detection of Molecules Using Metal-Organic Polyhedron Materials

Shimadzu RF-5301PC was used as a measuring instrument of fluorescence.

When 33 mg of Egg PC is hydrated with an aqueous solution containing 1 mM Carboxyfluorecein, it forms an Egg PC vesicle carrying carboxyfluorescein. After dialysis, the egg PC vesicles from which the external carboxyfluorescein has been removed are diluted in a 1 M methyl viologen solution, and fluorescence is measured by adding MOP-18 to observe the passage of methyl viologen. Figure 3a shows that the fluorescence intensity of carboxyfluoline is reduced by the methyl viologen passed when MOP-18 solution is added for 100 seconds. In the absence of methyl viologen, the fluorescence intensity of carboxyfluoline did not decrease.

MOP-18 can thus be effectively used as a sensor for molecules.

On the other hand, as in the method described above, when 33 mg of Egg PC is hydrated with an aqueous solution containing 12.5 mM ANTS and 45 mM DPX, ANTS forms vesicles in which the ANTS is quenched by DPX. After dilution of the egg PC vesicles from which the external ANTS and DPX were removed using a dialysis method, the fluorescence was measured by adding MOP-18. As shown in FIG. 3B, the fluorescence intensity of the unquenched ANTS did not increase. This means that DPX did not escape out of the endoplasmic reticulum, and the results showed that MOP-18 was able to selectively detect similar sized methyl viologen and DPX molecules. This is because DPX, which is similar in width but long, is difficult to pass through the MOP-18 by random motion.

Meanwhile, again 33 mg of Egg PC was hydrated in a buffer containing ^10-6 M HPTS dye, followed by a buffer containing 100 mM XCl (X = Li, Na, K, Rb, Cs). Dilution in the solution and the addition of MOP-18 to measure the intensity of fluorescence showed the results as shown in FIG. HPTS is a pH-sensitive dye that increases _Irel = I ₄₆₀ / I ₄₀₅ as the pH increases. In FIG. 5, lithium ions showed the greatest fluorescence intensity, which means that lithium ions pass through MOP-18 better than other ions and have the highest sensitivity.

Example 3: Antimicrobial Agents Using Metal-Organic Polyhedron Materials

MOP-18 was synthesized in the same manner as in Example 1, and then mixed with an emulsifier to be used as an antimicrobial agent.

MOP-18 is mixed 1: 1 with emulsifier lecithin and then added to the E. Coli culture medium by decreasing the concentration in steps of 100 μg / ml to 1.8 μg / ml in steps of 1/2. After 24 hours of E. Coli incubation at 37 ^o C, the minimum growth inhibitory concentration (MIC) was measured visually and the MIC value was about 7.2 μg / ml. It can be seen that MOP-18 exhibits good antibacterial properties.

1 is a view showing a three-dimensional crystal structure obtained by the X-ray crystal structure analysis method for one of the metal-organic polyhedron material MOP-18.

2A and 2B are graphs showing current values generated as ions pass by the metal-organic polyhedron material according to Example 1;

3A and 3B are graphs showing the change in fluorescence as methyl viologen and DPX pass through the metal-organic polyhedron material according to Example 2. FIG.

4 is a schematic diagram of an apparatus for measuring a current value according to passage of ions.

FIG. 5 is a graph showing the change in fluorescence according to the passage of various ions of the metal-organic polyhedron material according to Example 2. FIG.

6 is a schematic diagram showing that the metal-organic polyhedron material is inserted into the lipid membrane to pass ions or molecules.

Claims (19)

Separation method of ions, characterized in that selectively passing the ions using an ion channel containing a metal-organic polyhedron material of formula (I): <Formula 1>

In the above formula, M represents a metal ion, L ₁ , L ₂ , L ₃ , L ₄ , L ₅ and L ₆ each independently represent a monodentate ligand or a multidentate ligand, n represents an integer of 3 to 10,000. The method of claim 1, M is Mg ²⁺ , Ca ²⁺ , Sr ²⁺ , Ba ²⁺ , Sc ³⁺ , Y ³⁺ , Ti ⁴⁺ , Zr ⁴⁺ , Hf ⁴⁺ , V ⁴⁺ , V ³⁺ , V ²⁺ , Nb ³⁺ , Ta ³⁺ , Cr ³⁺ , Mo ³⁺ , W ³⁺ , Mn ³⁺ , Mn ²⁺ , Re ³⁺ , Re ²⁺ , Fe ³⁺ , Fe ²⁺ , Ru ³⁺ , Ru ²⁺ , Os ³⁺ , Os ²⁺ , Co ³⁺ , Co ²⁺ , Rh ²⁺ , Rh ⁺ , Ir ²⁺ , Ir ⁺ , Ni ²⁺ , Ni ⁺ , Pd ²⁺ , Pd ⁺ , Pt ²⁺ , Pt ⁺ , Cu ²⁺ , Cu ⁺ , Ag ⁺ , Au ⁺ , Zn ²⁺ , Cd ²⁺ , Hg ²⁺ , Al ³⁺ , Ga ³⁺ , In ³⁺ , Tl ³⁺ , Si ⁴⁺ , Si ²⁺ , Ge ⁴⁺ , Ge ²⁺ , Sn ⁴⁺ , Sn ²⁺ , Pb ⁴⁺ , Pb ²⁺ , As ⁵⁺ , As ³⁺ , As ⁺ , Sb ⁵⁺ , Sb ³⁺ , Sb ⁺ , Bi ^A method for separating ions, characterized by representing metal ions selected from the group consisting of ⁵⁺ , Bi ³⁺ and Bi ⁺ . The method of claim 1, The single site ligand is an amine compound, a halogen ion, an alcohol compound, a pyridine compound, a furan compound, H ₂ O, SCN ^- or CN ^- separation method, characterized in that. The method of claim 1, The multidentate ligand is a trimethate ligand, a terephthalate ligand, a 4,4'-bipyridine ligand, a 2,6-naphthalenedicarboxylate ligand, a pyrazine ligand, a benzenedicarboxylate ligand, a pyridine A dicarboxylate-based ligand, a biphenyl dicarboxylate-based, triphenylbenzene-based ligand, or triphenyldicarboxylate-based separation method of ions. The method of claim 1, and n is a number from 10 to 1,000. The method of claim 1, Isolation method of ions, characterized in that the metal-organic polyhedron material according to the formula (1) is inserted into the lipid membrane. Separation method of a molecule, characterized in that selectively passing through the molecule using a molecular channel comprising a metal-organic polyhedron material of formula (I): <Formula 1>

In the above formula, M represents a metal ion, L ₁ , L ₂ , L ₃ , L ₄ , L ₅ and L ₆ each independently represent a monodentate ligand or a multidentate ligand, n represents an integer of 3 to 10,000. The method of claim 7, wherein M is Mg ²⁺ , Ca ²⁺ , Sr ²⁺ , Ba ²⁺ , Sc ³⁺ , Y ³⁺ , Ti ⁴⁺ , Zr ⁴⁺ , Hf ⁴⁺ , V ⁴⁺ , V ³⁺ , V ²⁺ , Nb ³⁺ , Ta ³⁺ , Cr ³⁺ , Mo ³⁺ , W ³⁺ , Mn ³⁺ , Mn ²⁺ , Re ³⁺ , Re ²⁺ , Fe ³⁺ , Fe ²⁺ , Ru ³⁺ , Ru ²⁺ , Os ³⁺ , Os ²⁺ , Co ³⁺ , Co ²⁺ , Rh ²⁺ , Rh ⁺ , Ir ²⁺ , Ir ⁺ , Ni ²⁺ , Ni ⁺ , Pd ²⁺ , Pd ⁺ , Pt ²⁺ , Pt ⁺ , Cu ²⁺ , Cu ⁺ , Ag ⁺ , Au ⁺ , Zn ²⁺ , Cd ²⁺ , Hg ²⁺ , Al ³⁺ , Ga ³⁺ , In ³⁺ , Tl ³⁺ , Si ⁴⁺ , Si ²⁺ , Ge ⁴⁺ , Ge ²⁺ , Sn ⁴⁺ , Sn ²⁺ , Pb ⁴⁺ , Pb ²⁺ , As ⁵⁺ , As ³⁺ , As ⁺ , Sb ⁵⁺ , Sb ³⁺ , Sb ⁺ , Bi ^A method for separating molecules, characterized in that it represents a metal ion selected from the group consisting of ⁵⁺ , Bi ³⁺ and Bi ⁺ . The method according to claim 7, The monodentate ligand is an amine compound, a halogen ion, an alcohol compound, a pyridine compound, a furan compound, H ₂ O, SCN ^- or CN ^- separation method, characterized in that the molecule. The method of claim 7, wherein The multidentate ligand is a trimethate ligand, a terephthalate ligand, a 4,4'-bipyridine ligand, a 2,6-naphthalenedicarboxylate ligand, a pyrazine ligand, a benzenedicarboxylate ligand, a pyridine Separation method of the molecule | numerator characterized by the dicarboxylate-type ligand, a biphenyl dicarboxylate type | system | group, a triphenylbenzene type ligand, or a triphenyl dicarboxylate type | system | group. The method of claim 7, wherein Separation method of a molecule, characterized in that n is a number of 10 to 1,000. The method of claim 7, wherein Separation method of a molecule, characterized in that the metal-organic polyhedron material according to the formula (1) is inserted into the lipid membrane. A method for detecting ions, characterized by selectively passing ions using an ion channel comprising a metal-organic polyhedron material of Formula 1: <Formula 1>

In the above formula, M represents a metal ion, L ₁ , L ₂ , L ₃ , L ₄ , L ₅ and L ₆ each independently represent a monodentate ligand or a multidentate ligand, n represents an integer of 3 to 10,000. Method for detecting a molecule, characterized in that for selectively passing through the molecule using a molecular channel comprising a metal-organic polyhedron material of Formula 1: <Formula 1>

In the above formula, M represents a metal ion, L ₁ , L ₂ , L ₃ , L ₄ , L ₅ and L ₆ each independently represent a monodentate ligand or a multidentate ligand, n represents an integer of 3 to 10,000. An antimicrobial composition comprising a metal-organic polyhedron material of Formula 1 <Formula 1>

In the above formula, M represents a metal ion, L ₁ , L ₂ , L ₃ , L ₄ , L ₅ and L ₆ each independently represent a monodentate ligand or a multidentate ligand, n represents an integer of 3 to 10,000. The method of claim 15, M is Mg ²⁺ , Ca ²⁺ , Sr ²⁺ , Ba ²⁺ , Sc ³⁺ , Y ³⁺ , Ti ⁴⁺ , Zr ⁴⁺ , Hf ⁴⁺ , V ⁴⁺ , V ³⁺ , V ²⁺ , Nb ³⁺ , Ta ³⁺ , Cr ³⁺ , Mo ³⁺ , W ³⁺ , Mn ³⁺ , Mn ²⁺ , Re ³⁺ , Re ²⁺ , Fe ³⁺ , Fe ²⁺ , Ru ³⁺ , Ru ²⁺ , Os ³⁺ , Os ²⁺ , Co ³⁺ , Co ²⁺ , Rh ²⁺ , Rh ⁺ , Ir ²⁺ , Ir ⁺ , Ni ²⁺ , Ni ⁺ , Pd ²⁺ , Pd ⁺ , Pt ²⁺ , Pt ⁺ , Cu ²⁺ , Cu ⁺ , Ag ⁺ , Au ⁺ , Zn ²⁺ , Cd ²⁺ , Hg ²⁺ , Al ³⁺ , Ga ³⁺ , In ³⁺ , Tl ³⁺ , Si ⁴⁺ , Si ²⁺ , Ge ⁴⁺ , Ge ²⁺ , Sn ⁴⁺ , Sn ²⁺ , Pb ⁴⁺ , Pb ²⁺ , As ⁵⁺ , As ³⁺ , As ⁺ , Sb ⁵⁺ , Sb ³⁺ , Sb ⁺ , Bi An antimicrobial composition characterized in that it exhibits a metal ion selected from the group consisting of ⁵⁺ , Bi ³⁺ and Bi ⁺ . The method of claim 15, The monodentate ligand is an amine compound, a halogen ion, an alcohol compound, a pyridine compound, a furan compound, H ₂ O, SCN ^- or CN ^- characterized in that the antimicrobial composition. The method of claim 15, The multidentate ligand is a trimethate ligand, a terephthalate ligand, a 4,4'-bipyridine ligand, a 2,6-naphthalenedicarboxylate ligand, a pyrazine ligand, a benzenedicarboxylate ligand, a pyridine An antimicrobial composition comprising a dicarboxylate ligand, a biphenyldicarboxylate system, a triphenylbenzene ligand, or a triphenyldicarboxylate system. The method of claim 15, n is a number from 10 to 1,000 antimicrobial composition.

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