KR100868350B1 - Iontophoresis patch and manufacturing method thereof - Google Patents

Abstract

An iontophoresis patch is provided to improve the skin penetration effect of the interested material and retention property of the patch by forming an iontophoresis patch electrode and a battery into one system. An iontophoresis patch comprises: a patch sheet(10); a conductive electrode layer(20) being in contact with the patch sheet; a hydrogel layer(60) in which anode layer contains the manganese dioxide while being in contact with the conductive electrode layer and a cathode layer(50) containing the zinc are arranged to the either side, which comes into contact with each of the cathode layer and anode layer; and a current path connecting an anode layer and the cathode layer in the conductive electrode layer. The conductive electrode layer contains one of carbon and silver. The anode layer contains manganese dioxide, carbon, and binder.

Description

IONTOPHORESIS PATCH AND MANUFACTURING METHOD THEREOF}

The present invention relates to a patch system that uses the principle of iontophoresis as a means for penetrating the skin of substances of interest such as drugs and cosmetic substances.

Iontophoresis refers to a technology that allows microcurrents to flow through the skin to penetrate the substance of interest with charge into the skin by electrical repulsion. When a patch containing a substance of interest is attached to the skin, a circuit is formed to generate a current and the substance of interest penetrates into the skin by electrical repulsive force.

Conventional iontophoresis devices generally attach two electrodes to the skin of a human body and each electrode is connected to an electrical device through a wire. The substance of interest is placed on the surface of the electrode, and actuation of the electrical appliance causes penetration of the substance of interest into the body. Electrical appliances are designed to regulate the amount and time of current, a problem with these systems is that the patient is connected to the electrical appliance through a lead to limit the patient's daily movements and activities.

Recent patch-type iontophoresis systems have been developed to integrate electrical circuits and supply current into a single patch. Such a system consists of an iontophoresis patch and a battery in electrical connection. This is being evaluated as an advanced form compared to the method in which power was supplied to the wire from the outside.

The conventional iontophoresis patch was assembled after the patch and the battery were separately produced and inserted into the patch body by electrically connecting the cells. These iontophoresis patches are vulnerable to the preservation of the mounted batteries, and the assembly process is complicated, resulting in low productivity due to low productivity. In addition, the iontophoresis patch is not effective because it undergoes a multi-step reaction process. There was a limit to penetration.

The present invention is to solve the conventional technical problems as described above, by configuring the iontophoresis patch electrode and the battery as a system to increase the skin penetration efficiency of the material of interest and improve the preservation characteristics of the patch Its purpose is to provide a topography patch,

A patch sheet, a conductive electrode layer in contact with the patch sheet, an anode layer in contact with the conductive electrode layer and containing a manganese dioxide and a cathode layer containing zinc are disposed on both sides, and each of the anode layer and the cathode layer And a current passage connecting the anode layer portion and the cathode layer portion in contact with the hydrogel layer and the conductive electrode layer.

The present invention integrates the patch electrode and the battery for operating the same, excellent storage characteristics of the battery and can increase the efficacy of the patch, there is an effect that can facilitate mass production by simplifying the manufacturing process.

According to the present invention, when the patch layer 10 includes the conductive electrode layer 20 and the anode layer 40 on one side in contact with the conductive electrode layer and the cathode layer 50 on the other side, the patch is attached to the skin. It is characterized by operating on a battery.

Coating with a carbon ink on the cover sheet 10 of the patch to form a conductive electrode layer 20, the conductive electrode by applying a carbon ink made of carbon powder to have flexibility, manufacturing processability, and electrochemical resistance of the patch can do. Silver powder may be used instead of carbon powder.

A slurry formed of manganese dioxide powder, carbon powder, and a binder solution, which is a material generating current on one side of the conductive electrode, is coated and dried to form an anode layer 40 to operate as an anode, and to serve as an anode of the conductive electrode layer. A slurry made of zinc powder, carbon powder, and a binder solution, which is a material for generating a current, is coated on the other side of the layer and then dried to form a negative electrode layer 50 to operate as a negative electrode. The anode layer and the cathode layer are characterized by the use of powdered manganese dioxide and zinc for high current density and convenience in the manufacturing process.

Between the positive electrode layer and the negative electrode layer part constitutes a passage 30 connected by a conductive electrode so that a current flows, and attaching an insulating tape or film 70 to the current passage so that the current is not counted by direct contact with the skin when attached to the human body In addition, the power cut treatment is performed.

An ion conductive hydrogel layer 60 containing zinc chloride is formed on each of the anode layer and the cathode layer, and includes a substance of interest, which is a substance to be administered to the human body, together with a hydrogel, or a substance of interest during distribution. If it is difficult to secure stability, it can be packaged separately and sprayed on top of the hydrogel layer when using the patch. At this time, the electrode to be mounted is determined depending on whether the material of interest is positive or negative.

In addition, to prevent drying of the hydrogel of the iontophoresis patch, a non-transmissive film 60 is formed, and the non-transmissive film is attached to the hydrogel layer and cut in the shape of the patch to complete.

Iontophoresis patches affixed with a non-transmissive film are sealed with metal laminate film bags and distributed on the market. The sealing atmosphere is generally carried out in an atmospheric atmosphere, but when an oxidation reaction is concerned between the anode / cathode and the hydrogel, it is preferable to seal in an inert atmosphere or an oxygen free atmosphere.

[Example]

Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings.

1 is a cross-sectional view schematically showing the structure of the patch for iontophoresis according to the present invention. The patch sheet 10 may be a corona-treated polyethylene terephthalate (PET) film or a polyacrylonitrile (PAN) film. The conductive electrode layer 20 may be a carbon ink. Silk printing, offset printing, material evaporation and slurry coating techniques can be applied using metal powders such as silver inks or slurries composed of carbon components and polymers.

Carbon ink is printed on the patch sheet 10 and dried to form a conductive electrode layer 20 having a thickness of about 15 μm. At this time, the anode layer 40 is positioned on one side of the conductive electrode and the cathode layer 50 is placed on the other side of the conductive electrode layer. In the conductive electrode layer, the current passage 30 is formed so that a current flows between the anode layer portion and the cathode layer portion. Form. The width of the current passage is preferably 2 to 5 mm, more preferably about 5 mm.

A slurry made by mixing manganese dioxide powder, carbon powder, and a binder solution is printed on the conductive electrode layer to form an anode layer 40. As a material that serves as a cathode active material of a battery, various materials have been studied, but manganese dioxide is preferable in consideration of capacitance, voltage, electrochemical characteristics, and product distribution environment.

The binder solution applied is polyethylene oxide, polyvinyl alcohol, polyvinyl pyrrolidone, 2-hydroxyethyl cellulose, polymethyl methacrylate. ), And polyvinylidene fluoride (polyvinylidene fluoride) is prepared by adding a solvent to the polymer made of one or a combination thereof. A multi-component binder system that mixes two or more types of binders together, rather than a single binder, is advantageous in terms of electrical efficiency, mechanical strength, and adhesion to conductive electrodes. In particular, the combination of polyethylene oxide, polymethyl methacrylate, and polyvinylidene fluoride as the electrode binder was found to be excellent in durability and manufacturing processability of the electrode.

The cathode layer 50 is formed by contacting the conductive electrode layer and being disposed side by side with the anode layer and printing with a slurry in which zinc powder, carbon powder, and a binder solution are mixed. Although various materials have been studied as the negative electrode active material, in consideration of capacitance, voltage, electrochemical properties, and manufacturing processability, zinc in powder form is preferable, and polyethylene oxide and polyvinyl alcohol, which are binder solvents similar to the positive electrode, are preferred. (polyvinyl alcohol), polyvinyl pyrrolidone, polymethyl methacrylate (polymethyl methacrylate), or a combination of these solvents are added to the polymer is made of a polyethylene oxide (polyethylene oxide) , Polyvinylpyrrolidone, and polymethyl methacrylate were found to be excellent in electrical efficiency, manufacturing processability, and binding with the conductive electrode layer.

The thickness of the anode layer and the cathode layer is determined in consideration of the electrical capacity and the like and generally forms a thickness of about 80 ~ 100 ㎛.

2 is a plan view of a conductive electrode layer 20 formed on the patch sheet 10 in the structure of the iontophoresis patch according to the present invention.

3 is a plan view of the anode layer 40 and the cathode layer 50 disposed on both sides of the conductive electrode layer 20 in the structure of the iontophoresis patch according to the present invention. The distance between the anode layer and the cathode layer is preferably 1 to 20 mm, more preferably 4 to 10 mm, and may be designed to an optimal distance in consideration of the strength of the current flowing between the patch and the skin and the contact resistance.

In the conductive electrode layer, a current passage 30 is configured to allow a current to flow between the anode layer and the cathode layer, and the width of the current passage is 2 to 5 mm, which can be adjusted according to the strength of the current flowing between the anode and the cathode. It prevents a short circuit when attaching to the human skin by attaching insulating tape.

4 is a plan view of the hydrogel layer 60 formed on each of the anode layer 40 and the cathode layer 50 in the structure of the iontophoresis patch according to the present invention. An ion conductive hydrogel layer 60 in which zinc chloride is dissolved to serve as an electrolyte is formed on the anode layer and the cathode layer. Hydrogels are generally made of a hydrophilic gel material and are mainly prepared by mixing agarose and polyvinyl alcohol with water in which the electrolyte is pre-dissolved. The electrolyte preferably contains any one of zinc chloride, ammonium chloride, sodium chloride or a combination thereof.

In the distribution of the present invention, in order to prevent evaporation of the hydrogel component, a non-permeable film is attached on the hydrogel layer 60, and put into a metal laminate bag, and when used, the patch is taken out of the bag and adhered to the hydrogel layer. After removing the film, the material of interest (cosmetic material) is sprayed or pasted onto the electrode for use.

As described above, although the present invention has been described with reference to limited embodiments and drawings, the terms or words used in the present specification and claims are not to be construed as being limited to ordinary or dictionary meanings, and are consistent with the technical spirit of the present invention. It must be interpreted as meaning and concept. Therefore, the embodiments described in the specification and the drawings shown in the drawings are only one embodiment of the present invention and do not represent all of the technical idea of the present invention, and various equivalents that may be substituted for them at the time of the present application and It should be understood that there may be variations.

1 is a cross-sectional view schematically showing the structure of the iontophoresis patch according to the present invention.

2 is a plan view of a conductive electrode layer constructed on a patch sheet.

3 is a plan view showing an anode layer and a cathode layer constructed over the conductive electrode layer;

4 is a plan view showing a hydrogel layer constructed over an anode layer and a cathode layer

<Explanation of symbols for main parts of the drawings>

10: patch sheet 20: conductive electrode layer

30: current path 40: anode layer

50: cathode layer 60: hydrogel layer

70: insulation film

Claims (18)

As an iontophoresis patch, With patch sheet, A conductive electrode layer in contact with the patch sheet; A positive electrode layer containing manganese dioxide and a negative electrode layer containing zinc are disposed on both sides in contact with the conductive electrode layer, A hydrogel layer in contact with each of the anode layer and the cathode layer; And an iontophoresis patch comprising a current path connecting the anode layer and the cathode layer in the conductive electrode layer. The method of claim 1, The patch sheet is made of any one of polyethylene terephthalate (PET: polyethylene terephthalate) and polyacrylonitrile (PAN: polyacrylonitrile), the patch thickness of the iontophoresis patch, characterized in that 20 ~ 50㎛. The method of claim 1, The iontophoresis patch, characterized in that the conductive electrode layer contains any one of carbon and silver. The method of claim 1, And the anode layer contains manganese dioxide, carbon and a binder. The method of claim 4, wherein The binder is polyethylene oxide, polyvinyl alcohol, polyvinyl pyrrolidone, 2-hydroxyethyl cellulose, polymethyl methacrylate, Iontophoresis patch, characterized in that consisting of any one or a combination of polyvinylidene fluoride (polyvinylidene fluoride). The method of claim 1, An iontophoresis patch, characterized in that the negative electrode layer contains zinc and a binder. The method of claim 6, The binder is ionic soil, characterized in that any one or a combination of polyethylene oxide, polyvinyl alcohol, polyvinyl pyrrolidone, polymethyl methacrylate (polymethyl methacrylate) Foresis Patch. The method of claim 1, An iontophoresis patch, characterized in that the thickness of the anode layer and the cathode layer is 80 ~ 100㎛. The method of claim 1, Iontoporesis patch, characterized in that the hydrogel layer contains any one or a combination of zinc chloride, ammonium chloride, sodium chloride. The method of claim 9, Iontophoresis patch, characterized in that the concentration of any one or a combination of zinc chloride, ammonium chloride, sodium chloride relative to the total weight of the hydrogel is 0.1 to 20% by weight. The method of claim 1, Iontophoresis patch, characterized in that the distance between the anode layer and the cathode layer is 1-20 mm The method of claim 1, Current path is an iontophoresis patch, characterized in that the current flows by connecting between the anode layer and the cathode layer in the conductive electrode layer The method of claim 12, An iontophoresis patch, wherein the current passage has a width of 2 to 5 mm. The method of claim 12, And an insulating material layer on top of the current path layer to prevent a short circuit of the current path. Preparing a conductive electrode layer in contact with the patch sheet and printed and coated using any one of an ink and a slurry composed of any one of carbon powder and silver powder; Preparing a positive electrode layer in contact with the conductive electrode layer and mixing the manganese dioxide powder, the carbon powder, and a binder solution to be printed by coating a slurry; Preparing a negative electrode layer in contact with the conductive electrode layer and disposed at a predetermined distance from the positive electrode layer to mix zinc powder and a binder solution, and to print and coat the slurry with a slurry; Preparing a hydrogel layer in contact with each portion of the anode layer and the cathode layer; And And manufacturing a current path connecting the anode layer and the cathode layer in the conductive electrode layer. The method of claim 15, A method of making an iontophoresis patch comprising attaching a non-transmissive film in contact with a hydrogel layer of an iontophoresis patch. The method of claim 16, A method for producing an iontophoresis patch, comprising: sealing the iontophoresis patch with a metal laminate wrapper in either a vacuum atmosphere or an oxygen free atmosphere. The method of claim 17, The oxygen-free atmosphere is any one of argon, helium, hydrogen, nitrogen, or a combination thereof.

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