KR100775669B1 - A wristwatch-like, portable device for noninvasive blood glucose measurement - Google Patents

Abstract

A wristwatch type portable apparatus for non-invasive blood glucose measurement is provided to improve the SNR(Signal to Noise Ratio) of an NIR(Near Infra-Red) signal by irradiating a plurality of lights on various parts of a skin. A wristwatch type portable apparatus for non-invasive blood glucose measurement includes a digital display panel(7), a plurality of fibers(10), a detector, an NIR emitter(12), an NIR detector(14), a differential amplifier(20), and an analog/digital converter(21). The digital display panel has a clock and a button at the upper surface, and displays a blood glucose level. The plurality of fibers irradiate near infrared rays on the skin. The detector is formed at the bottom center to receive an NIR signal which is re-reflected outside the skin after traveling inside the skin. The detector and the NIR emitter are connected to a circuit board which is connected to a display controller(16) to display the measured blood glucose level. Two wavelength NIR detector detects the signal difference between a wavelength 1(lambda1) and a wavelength 2(lambda2) by collecting the near infrared rays irradiated on the skin in the detector. The differential amplifier amplifies the difference value between the two near-infrared rays. The analog/digital converter converts the difference value to a digital value, calculates the blood glucose level corrected by a microcontroller memory(25), and displays the calculated blood glucose level in three numbers at the digital display panel.

Description

A wristwatch-like, portable device for noninvasive blood glucose measurement

Figure 1a is a wrist watch type bloodless near-infrared blood glucose meter plan configuration of the present invention.

Figure 1b is a rear view of the wrist watch type bloodless near-infrared blood glucose meter of the present invention.

Figure 2 is an internal configuration according to the light-receiving portion and the light-transmitting fiber formed on the back of the wrist portable bloodless blood glucose meter of the present invention.

Figure 3 is a state of use of the blood glucose measurement apparatus according to the present invention shows the state of near-infrared light transmission and light penetration, light reception when acting on the skin.

4 is a graph showing the near-infrared absorption state of the constituents of the present invention as (a), (b), (c) and (d).

5 is a blood glucose correction straight line graph of the present invention.

Figure 6 is a system block diagram according to the near infrared (NIR) blood glucose sensor of the present invention.

7 is a flowchart illustrating a method for measuring blood glucose free blood glucose concentration according to an embodiment of the present invention.

<Description of Signs of Major Parts of Drawings>

3: LCD DISPLAY 9: Receiver

10: light transmitting fiber 12: near infrared light emitting portion (NIR Emitter)

13: Radiation Window 14: Near-Infrared Light Receiver

16: Display controller 17: Circuit board

20: differential amplifier 21: analog / digital converter

22: Temporary storage 23: Signal controller

24: Amplifier 25: Microcontroller

26: button 27: power management device

The present invention relates to a blood-free blood glucose meter by a near infrared (NIR) spectroscopy (Spectroscopy) to simply check the blood sugar simply by wearing on the skin, such as the wrist. More specifically, the present invention relates to a system for easily and accurately measuring blood glucose values by conventional complex multivariate statistical techniques by selecting two special near-infrared wavelengths and efficiently receiving two special wavelengths.

That is, in the present invention, when a blood glucose meter formed like a watch is worn on the wrist, near infrared rays are irradiated from the light transmitting fiber formed on the back of the blood glucose meter and the sensing head to penetrate the skin, and the near infrared rays penetrated into the skin come into contact with blood glucose molecules on the inner surface of the skin. And then reflected back and received by the light-receiving part formed in the center of the head of the blood glucose meter, the received near-infrared energy is first overtone of CH stretching when the carbon hydrogen atom of the sugar (C ₆ H ₁₂ 0 ₆ ) molecule is expanded. mode) absorbs 1.5-1.8㎛ wavelength and spectroscopically analyzes the energy absorption of this near-infrared wavelength to detect blood glucose concentration and display it on the digital display formed on the front side of the blood glucose measurement device. The present invention relates to a portable bloodless blood glucose measurement apparatus.

In general, a blood glucose meter is a device for measuring glucose contained in blood. Conventional measuring methods are known in the art for instantly analyzing the concentration of blood components collected by puncturing body parts such as fingers. Devices for measuring the concentration of these blood components are painful by frequent puncture of the finger and blood, there is a problem that there is considerable pain and discomfort to the patient.

In addition, looking at the pre-registered cases of such a blood glucose meter, such as Utility Model Registration No. 0406331 discloses that it is easy to carry and to measure blood pressure and blood sugar with a single measuring device. It is combined with a blood pressure measuring unit for measuring blood pressure and provided with a controller for controlling the measured signal and a display unit for displaying the measured signal to the outside and a blood sugar measuring unit for measuring blood sugar to be wound around the wrist. will be.

However, Utility Model Registration No.0406331, which is registered in advance, allows a certain amount of blood (hereinafter referred to as a sample) to come out through a separate blood collection device so as to drop a sample collected in a drop port of an elongated shape of a test strip. As a way to measure the blood sugar by flowing to the reaction site containing the oxidase is also a problem that must be collected.

As another embodiment, Patent No. 0300960 uses a multi-color light source that emits a specific light in the near infrared region of 800-1850nm as a light source, the light is backscattered in the affected area or transmitted to the affected area, blood-containing tissues and blood vessels Since backscattered light has information on the concentration of blood components, it ensures that light is properly received to avoid surface reflections on the skin surface and to minimize the effects associated with changes in the backscatter background. Calculated by spectroscopic analysis based on the wavelength selected by the proposed algorithm, the microprocessor calculates a certain ratio by referring to the measurement curve stored in the memory of the microprocessor, determines the concentration of blood components, and displays the concentration value. Disclosed is a bloodless measurement method and apparatus for displaying a blood component concentration.

However, conventional blood glucose meters, such as patent 0300960, have a partial minimum for each component to induce the degree of near infrared energy absorption absorbed by the blood sugar by distinguishing the infrared energy absorption absorbed by other components in addition to the blood glucose. Blood glucose levels were measured by calibration induced by a multivariate statistical technique. However, this calibration method is very complicated because there must be quantitative data for all skin components, which also has a big problem that does not take into account the near infrared (NIR) signal variation due to the skin characteristics of each user.

The present invention has been invented in view of the above problems, by developing a portable blood glucose meter based on blood glucose near-infrared (NIR) absorption spectrometry, and simply checking the blood sugar accurately and simply by wearing it on the wrist The purpose is to allow the diabetic patients as well as the general public to measure their own blood sugar at any time without collecting blood.

The present invention having such an object does not require correction by the multivariate statistical technique of the conventional complex partial least squares method, which requires quantitative measurement data of all skin components, and these components do not require blood glucose NIR. By selecting the wavelength 1 (λ1) and the wavelength 2 (λ2) that can cancel or minimize the signals of other components that interfere with the infra-red (NIR) absorption quantification, hemoglobin, This method minimizes the effect of blood glucose measurement on other components by offsetting or minimizing water and blood components.

The calibration curve derived in this way is a straight line of the linear equation and only the two coefficients of the linear equation, the slope and the y-axis intercept, are needed. The slope is obtained by the blood glucose absorbance for wavelength 1 (λ1) and wavelength 2 (λ2), which is input to the memory device during the calibration process, and the customer only needs to do one point calibration to obtain the Y-axis intercept value.

In addition, the NIR light is transmitted to the skin tissue so that a large number of light transmission through the optical fiber (NIR) light so that the light reflected directly from the surface of the skin is irradiated to the light-receiving portion to the adhesive irradiation, and irradiated NIR light energy that penetrates up to 3mm in the inner skin of skin and comes into contact with blood sugar molecules and is diffusely reflected off the skin. It is to provide a measuring device.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

Figure 1a is a front configuration diagram of the cuff portable blood glucose meter of the present invention, Figure 1b is a rear configuration diagram of the cuff portable blood glucose meter of the present invention.

The sensing head is configured on the back of the blood glucose meter of the present invention and the near infrared ray Six light-emitting fibers 10 for irradiating light to the skin are formed, and near-infrared light is transmitted from the light-transmitting fiber 10, and near-infrared light (NIR) penetrates to the inside of the skin to 3 mm to form blood sugar molecules. The light-receiving part 9 which receives near-infrared rays which come in contact with and re-reflects out of the propagation skin in various ways is formed.

In addition, when irradiating near-infrared light to the skin to increase the signal to noise ratio (SNR), the light emitting surface and the light receiving surface are formed on the same surface to minimize the loss due to diffuse reflection directly on the skin surface. By making the surface adhere to the skin, NIR light diffused directly from the skin surface cannot be infiltrated into the light receiving portion.

Rather than detecting blood glucose in one part of the skin tissue, the present invention is irradiated with a plurality of parts of the skin to absorb blood sugar molecules in various parts of the skin tissue, thereby absorbing a near infrared (NIR) signal. Increase the (SNR).

Figure 2 shows the sensing head formed on the back of the wrist portable bloodless blood glucose meter of the present invention and is an internal configuration according to the light-receiving unit and the light-transmitting fiber, by irradiating the skin in six directions to six irradiation light to the inner surface of the skin in six paths The contact with blood glucose molecules in the cell allows for more efficient screening of blood glucose molecules than near-infrared (NIR) absorption by a single light.

Looking at the configuration of Figure 2 formed six small source infrared light transmitting fibers (Fiber) (10) in contact with the skin of the cuff, but the overall arrangement of the fiber (Fiber) 10 was configured in a circular shape. The overall circular placement of the six fibres ensures that the near-infrared light being irradiated is as even and evenly as possible on the skin of the wrist. The light-transmitting fiber (Fiber) is irradiated with 1 ~ 2㎛ light generated from the NIR emitter (NIR Emitter).

In addition, in the center of the light transmitting fiber 10 having a circular shape as a whole, a light receiving portion (NIR Detectdr) 9 is formed larger than the light transmitting fiber, and irradiated near-infrared light penetrates into the skin 3mm, contacts with blood sugar, and is then diffusely reflected again. It is formed to increase the reception rate of the near-infrared rays.

The NIR emitter 12 for irradiating near infrared rays with the fiber 10 and the NIR detectdr 14 for receiving near infrared rays are a circuit board 17 having a circuit component 15. ) And the received signal of the battery 19 can be displayed on the upper display panel via the circuit board 17.

3 is a state diagram showing a state in which near-infrared light (NIR) light transmission and light reception and penetration of light when the blood glucose measurement device according to the present invention is applied to the skin, the light (Beam) irradiated from the blood glucose meter is good to penetrate the skin tissue In order to collect light without scattering the light, 200μm of light is irradiated with a core of 200μm fiber, and the irradiation angle is adjusted so that the near-infrared light can receive the reflected light to the maximum of 3mm of the skin. Decide on it.

The light irradiated from the fiber 10 is generated by the NIR emitter 12 and radiated to the outside by the radiation window 13, and six light-transmitting fibers are equalized in the radiation window 13. The optical fibers are fused to take one near infrared (NIR) energy.

The light receiving unit 9 is the same as the window size of the NIR detector 14, and the distance 21 D from the center of the light receiving unit to the center of the light transmitting fiber 10 is 7 mm, and the near infrared light is emitted. The angle applied to the skin is inclined toward the light-receiving portion by 10 degrees to efficiently receive near-infrared (NIR) light that is reflected and injected up to 3 mm below the skin.

In the process of irradiating the infrared light to the subcutaneous tissue up to about 3mm and reflected out of the skin, the near-infrared energy is the first energy bond due to the vibrating stretching of the carbon hydrogen atom bond axis of sugar (C ₆ H ₁₂ O ₆ ) molecules. Absorbs a wavelength of 1.5-1.8 μm, and analyzes the amount of energy absorption at this infrared wavelength by spectroscopy to detect the concentration of blood glucose.

Spectroscopy used in the present invention refers to absorption and radiation of a material by spectroscopy, spectrophotometer, etc., divided into spectroscopy and analyzed, and the energy level, structure, transition probability, temperature, etc. of the material. Refers to the field of optics researching.

Figure 4 is a graph showing the infrared absorption state of the components of the present invention (a), (b), (c), (d), the X-axis shows the infrared wavelength, the Y-axis shows the infrared absorbance, water other than blood sugar, hemoglobin The components such as blood and blood also absorb the near-infrared energy of this wavelength band, so it should be able to measure only the amount of blood glucose absorption except the amount absorbed by them.

About 70% of the human body is composed of water, and the near-infrared absorbance of water (Absorbance) is as shown in Fig. 4 (b), and the absorbance spectra is the absorbance of blood in Fig. 4 (d). It can be seen that the same as). In FIG. 4, the X-axis represents the near infrared wavelength and the Y-axis represents the absorbance. The absorbance of each component is different depending on the near-infrared wavelength.

In addition, two near-infrared wavelengths 1 (λ1) and wavelengths 2 (λ2) having the same absorbance of each component as the interference of absorption other than blood sugar may be selected to cancel their interference.

That is, as shown in Figs. 4A, 4B, and 4D, the absorbances are the same at wavelength 1 (λ1) and wavelength 2 (λ2). However, since the blood glucose absorbance of FIG. 4 (c) is different, the signals of (a), (b), and (d) are canceled and only the blood glucose of FIG. 4 (b) can be measured.

According to the Beer Lambert equation, the total absorbance of the near infrared wavelength 1 (λ1) absorbed by the skin tissue through moisture, hemoglobin and blood glucose is expressed as follows.

Where, where

ε _G1 : Glucose molar absorptivity at λ1

ε _H1 : Hemoglobin molar absorptivity at λ1 (hemoglobingram molecular absorbance)

ε _W1 : Water molar absorptivity at λ1 (water gram molecular absorbance)

c _G : sugar concentration

c _H : hemoglobin concentration

c _W : water concentration

σ ₁ : Infrared response signal by skin structure of each person

If another infrared wavelength 2 (λ2) having the same infrared absorption power of moisture or hemoglobin is selected as shown in Fig. 4, the total absorbance by this wavelength 2 (λ2) is expressed by Equation 2 and It can be obtained as shown in Equation 3.

If we find the difference between Eq.1 and Eq.2,

As shown in Fig. 4 (a), the wavelength 2 (λ2) was selected as ε _H1 = ε _H2 and ε _W1 = ε e _W2 , so the hemoglobin and moisture absorbance terms in Eq.3 are ε _H1 -ε _H2 , and ε _{The term W1} -ε _W2 becomes zero, and the response of the infrared signal wavelength 1 (λ1) and wavelength 2 (λ2) by each person's skin structure does not differ so much that (s ₁ -s ₂ ) becomes zero, so Eq.3 Only the sugar absorbance term remains as follows.

Equation 4 is a near-infrared (NIR) signal represented by a slope Δε _G for the variable c _G to be measured, a linear equation of S _G , and can be summarized as follows.

로서 ε_G1, ε_G2 는 파장1(λ1), 파장2(λ2)에 대한 수분 흡광도로서 상수이며, 이 Δε _G 는 마이크로 제어 기억장치(Microcontroller Memory)(25)에 기억된다. In equation (5)

Ε _G1 , ε _G2 are the moisture for wavelength 1 (λ1), wavelength 2 (λ2) The absorbance is a constant and this Δε _G is stored in the microcontroller memory 25.

In addition, Equation 5 C is a calibration integer and must be calibrated by each user. Equation 5 is a one-point calibration (blood glucose measurement straight line) is determined. This blood glucose measurement straight line is shown in FIG.

5 is a blood glucose calibration line graph of the present invention. As shown, the slope Δε _G is a constant determined by the wavelength 1 (λ1) and the wavelength 2 (λ2), and thus, Line 1 and Line 2 The slope of 2) is the same, but its position is different by the calibration constants C and C '. This calibration constant, C, is the residual signal whose other components other than blood sugar are not completely canceled for wavelength 1 (λ1), wavelength (λ2), or Eq. The response (s ₁ -s ₂ ) to each person's skin structure to wavelength 1 (λ1) and wavelength 2 (λ2) of ₃ is a non-zero residual signal and an integer due to other device noise.

Near-infrared rays of 1 to 2 탆 are generated by the near-infrared light emitter (NIR Emitter) 12, so that the near-infrared (NIR) energy is uniformly taken by the six light transmitting fibers 10 in the radiation window 13 of the light-emitting part 13 9) Draw a concentric circle with a radius of about 9 mm from the center and radiate six rays from the surface of the skin at a 60 degree circumference.

1 to 2 μm infrared rays diffused through the skin are all gathered into one light receiving unit 9, and the collected infrared rays are wavelength 1 by two color near-infrared light receiving units 14 shown in FIG. 6. (λ1) and wavelength 2 (λ2) are detected, and S _G0 of Equation 5 is detected by the differential amplifier 20 as shown in FIG.

Blood sugar level The C _GO is measured by a blood collection method during initial calibration. Substitute this C _GO value into Equation 6 to obtain the C value from the following equation.

The C value is stored in the storage device 25. That is _{, the} calibration line 1 obtained by S _GO, C _{GO, and} C is shown in FIG.

Therefore, once the initial straightening (Calibration) according to the shape of the skin structure of the user to obtain a straight line Line1 shown in Figure 5 to calculate the blood glucose concentration C _G1 by the following equation.

In other words, irradiated with 1-2㎛ infrared light on the skin, the skin is diffused out of the skin after traveling the tissue Wavelength 1 (λ1) and wavelength 2 (λ2) are detected by the near-infrared detector 14 of two color wavelengths (Two Color means two different wavelengths), and the two infrared wavelength energy differences S _G1 of Equation 6 is obtained from the differential amplifier 20 of FIG.

Figure 6 shows the near infrared (NIR) blood glucose sensor system block diagram of the present invention.

The value of S _G1 is converted into digital data by an analog / digital converter (A / D) converter 21 and stored in the data temporary storage 22 and stored in a microcontroller (Microcontroller) ( Calculate the equation (7) to obtain C _G1 .

The calculated C _G1 is displayed on the digital display 7 by three numbers on the liquid crystal display 3 by a display controller 16.

It is shown graphically in the non-blood glucose concentration as measured by the C _G1 wavelength near infrared (NIR) Fig.

As shown in FIG. 1 of the present invention, the portable wrist-free blood glucose meter allows a user to program a desired frequency of measurement, a low blood sugar level, a high alarm value, and the like with an initial mode calibration. At this time, an initial setting and a calibration method will be described with reference to the flowchart shown in FIG. 7.

FIG. 7 is a flowchart illustrating a blood glucose concentration measuring method according to an exemplary embodiment of the present invention. When the user inserts a battery, the power management apparatus of FIG. (27) is checked by a circuit and if the battery is weak the warning lamp (8) will flash.

The battery 19 supplies power to each circuit of FIG. The NIR emitter 12 which emits near-infrared light is pulsed at a predetermined period by a timing controller 23 by an amplifier 24.

When the reset button 5 is pressed once in step 31 of FIG. 7, step 32 is switched to the calibration mode. At this time, the user touches the sensing head 2 of FIG. 1 to the wrist to irradiate the skin with 1-2 μm NIR, and the wavelength 1 (λ1) and the wavelength 2 (λ2) that are diffusely reflected out of the skin through the skin tissue. A two color near infrared detector 14 is detected and the reaction equation 5, which is the difference between the two near infrared wavelength energies, is measured.

The S _GO measured by step 33 is stored in memory 25. The actual corresponding to this S _GO signal The blood glucose concentration is determined by the blood collection method in step 35, and the C _GO is calculated and adjusted in step 34 by pressing the calibration up / down button 6 so that the value is displayed on the liquid crystal display 3. At this time, C _GO is stored in the microcontroller 25.

When the C _GO value in step 36 is displayed on the digital display unit 7, the flow proceeds to step 37. The reset button 5 is pressed twice to execute the step 38 measurement frequency program.

The initial display is 001, which continuously measures blood glucose levels every 10 minutes. 002 measures blood glucose levels three times every hour and 003 once every hour. 004 is a mode in which a user can input a desired time. If 1330 is input, blood glucose measurement is automatically performed at 1:30 pm. Entering 0000 terminates this measurement time entry. This measurement frequency program is completed by pressing the reset button 5 three times and proceeding to step 4.

In step 4, the liquid crystal display (LCD) displays the blood sugar level low alarm value 70. Therefore, the user presses the Calibration Up / Down Button 6 to set the desired blood glucose level Low alarm value. This setting is terminated by pressing the Reset Button (5) to enter the blood glucose level High setting mode.

The initial blood glucose level is displayed with the High alarm value 250. Press the Calibration Up / Down Button (6) to set the user's desired high glucose level alarm.

When this setting is completed, press the Reset Button (5) four times. Pressing the Reset Button (5) four times ends the user program and enters the ready state.

At this time, if the initial user program is not in a state, the LCD 3 flashes.

In addition, the present invention is an example of a watch-type measuring device for wearing a blood sugar measuring device in the cuff in the above embodiment is that the wrist portion of the human body has the least subcutaneous fat in the body and at the same time easy to digital display of blood sugar at the same time As it can be confirmed, it is considered the most preferable type of blood glucose meter.

In the present invention, the blood glucose meter is not necessarily insisted on the watch type to be worn on the wrist, can be installed on the pedometer to check the walking movement during production, if necessary, can be worn on the ankle, another embodiment in the form of a necklace I can make it.

However, the blood glucose meter of the present invention should be worn on a convenient part of the body part for those who need to check their blood sugar regularly, such as diabetics, and travel the epidermal layer of the skin by irradiating the skin with near-infrared light. It is not preferable to wear it on fat and excessive muscle part of the wearer's body part because accurate measurement is made only after it is reflected back out of the skin again.

According to the simulation, the number of near-infrared light formed to irradiate the skin in the blood glucose meter of the present invention is less than three according to simulation, and according to the irradiation area, the number of light of the light emitting part can be increased to make a lot of contact with blood glucose molecules. By simulation, the maximum number of light transmissions should be determined so that travel paths in the skin tissue of each light do not overlap.

When the irradiation area of this invention is about 4 cm <2>, six are the most effective. In addition, the six near-infrared light transmitting fibers formed to irradiate the skin from the blood glucose meter of the present invention is a shape of a measuring device worn in the form of a bracelet or a clock, so that the shape of a circle or a square is most frequently used. It is determined that it is most appropriate since the light transmitting fibers are formed into a hexagonal shape as a whole.

The present invention as described above provides a blood glucose meter to be worn on the wrist to check the blood sugar simply by wearing if you need to check the blood sugar, such as diabetic patients can be free from the pain of frequent blood collection and at the same time simple blood sugar management It has the effect of making it easy.

In addition, when irradiating NIR (NIR) light to the skin to increase the light receiving signal, the light emitting surface and the light receiving surface should be on the same surface in order to minimize the loss due to diffuse reflection directly on the skin surface without penetrating the skin. By adhering to the skin, NIR light diffused directly from the skin surface is prevented from infiltrating into the light-receiving part.

Rather than detecting blood sugar in one part of the skin tissues, the present invention has the effect of increasing the received signal of the absorbed near-infrared signal by irradiating a plurality of light to various parts of the skin so that it can come into contact with blood sugar molecules in various parts of the skin tissue. Have

Claims (10)

In the bloodless meter that can measure blood sugar, A digital display unit 7 provided with a clock and a button on the upper surface thereof to display a blood sugar level; A plurality of light-emitting fibers 10 adapted to irradiate the skin with near-infrared light on the back contacting the wearer's skin; A light-receiving portion 9 formed at the center of the bottom to receive the near-infrared light which is transmitted by the transmitted near-infrared light and then reflected back out of the skin; The light receiving unit and the near infrared light transmitting unit 12 are connected to the circuit board 17, and the circuit board is connected to the screen display controller 16 so as to display the measured blood glucose level on the liquid crystal display. Near-infrared light 1-2 μm is irradiated to the skin with the light-transmitting fiber 10, and the near-infrared light 1 is collected by the two-wavelength near-infrared light-receiving unit 14 by collecting the near-infrared light diffused by the light-receiving unit 9 after traveling the skin tissue. Detects the signal difference between λ1) and wavelength 2 (λ2) and amplifies the detected difference between the near infrared energy with the differential amplifier 20 and converts the value into a digital value in the analog / digital converter 21 A cuff portable blood glucose measurement apparatus characterized in that the blood glucose concentration can be measured by calculating the blood glucose value corrected by the control memory device (25) and displaying it on the digital display (7) as three numbers. The method of claim 1, The wavelength 1 (λ1) and the wavelength 2 (λ2) introduced into the light receiving unit select two near-infrared wavelengths 1 (λ1) and wavelength 2 (λ2) having the same absorbances as other components of the blood sugar constituting the human skin, thereby preventing their interference. Cuff portable bloodless blood glucose measurement device, characterized in that the offset. The method of claim 1, A wrist-free blood glucose measurement apparatus for wrists, characterized in that the near infrared signal of wavelength 1 (λ1) and wavelength 2 (λ2) is received by the differential amplifier 20 to remove the near-infrared response variation due to human skin structure. . The method of claim 1, A wrist-free blood glucose measurement apparatus for wrists, characterized in that the wavelength 1 (λ1) and the wavelength 2 (λ2) introduced into the light receiving unit can be used at a wavelength of 1.5 μm to 1.8 μm having the same absorbance of water, hemoglobin, and blood. The method of claim 1, Near-infrared is absorbed by wavelength 1 (λ1), wavelength 2 (λ2) near-infrared absorption spectroscopy and measured by two-color data. Wavelength 1 (λ1) and wavelength 2 (λ2) detected by differential amplifier 20 Cuff portable blood glucose measurement device, characterized in that corrected by the difference of the signal. The method of claim 1 The plurality of light-transmitting holes form near-infrared rays emitted from the NIR emitter 14 to be arranged concentrically on the outer circumferential surface of the light-receiving portion 9 made of four or more optical fibers, so that near-infrared light passes through various parts of the skin, thereby causing blood glucose molecules. Cuff portable blood glucose measurement device, characterized in that configured to be in contact with. The method of claim 1, Cuff portable blood glucose measurement apparatus, characterized in that the near-infrared radiation window and the light-receiving surface is in close contact with the skin surface so that near-infrared radiation does not directly enter the light receiving portion (9). The method of claim 1, A wristless bloodless blood glucose measurement apparatus characterized in that the light-transmitting fiber is formed to be inclined toward the center of the light receiving hole so that near-infrared light penetrates into the skin and effectively reaches the light receiving portion. The method of claim 1,  A light-transmitting fiber (Fiber) is a cuff portable blood glucose measurement apparatus characterized in that the plurality of light-emitting fibers (Fiber) is connected to the near-infrared light (NIR Emitter) to be inclined toward the light receiving hall side. The method of claim 1, Blood sugar measuring device is a cuff portable blood glucose measurement device, characterized in that configured to be portable to wear on the wrist.

Images