KR100765960B1 - FET Nerve Electronic Chip - Google Patents

Abstract

The present invention relates to a neural electronic chip using a field effect transistor, the collagen tube 200 is penetrated between the nerve fibers 110 of the nerve 100 at the end of the nerve 100 consisting of the nerve fibers 110, 200 And, located at the end of the nerve fiber 110, attached to contact with the collagen tube 200, consists of a source 330 and drain 340 formed on the silicon 320, the nerve signal measurement function In the case of having a current can be output to the current output 360 by using the electric field formed at the end of the nerve fiber 110 as a drive signal, and having a nerve stimulation function to the potential across the source 330 and the drain 340 A neural electronic terminal 300 having a field effect transistor (FET) 310 for transmitting an electrical stimulus signal to the neural fiber 110 by an electric field generated by the electric field, and the neural electronic terminal 300. Install this And a frame 500 coupled to the neuron and collagen tube 200 and the suture unit 120 and installed on the frame 500 and connected to the array of the field effect transistor 310. In the case of having a function of stimulating the nerve 100, the electric field effect transistor 310 is controlled and driven by the stimulus signal 470 to generate an electric field for stimulating the end of the nerve fiber 110. In case of having a function of measuring a neurotransmitter electrical signal of the nerve 100, an analog / digital converter for converting the current output 360 of each field effect transistor 310 into a digital signal and outputting a nerve signal 472 Neural computer chip 400 composed of 453 and the frame 500, the input and output of the stimulus signal 470 and the nerve signal 472 of the neural computer chip 400, the external device Connectable Mouth / Relates to a neural electronic chip characterized in that the configuration including the output pin 510.

According to the present invention, by mounting a nerve electronic chip on the end of the nerve fiber damaged by cutting, etc. can measure the nerve signal transmitted from the nerve as an electrical signal, the electrical stimulation signal is transmitted to the nerve fiber nerve signal In addition, the nerve signal can be transmitted even when the nerve is damaged, and there is an advantage that the breakthrough can be developed in electronic control of the prosthetic and prosthetic leg.

Field effect transistor, nerve, nerve fiber, measurement, stimulation

Description

Neural electronic chip using field effect transistor {FET Nerve Electronic Chip}

1 is a schematic diagram of an apparatus for detecting brain cell signals according to an exemplary embodiment

2 is a block diagram of a neural electronic chip according to an embodiment of the present invention

3 is a diagram illustrating a coupling process of a neural electronic chip to a nerve according to an embodiment of the present invention

4 is a structural diagram of a frame of a neural electronic chip according to an embodiment of the present invention

5 is a structural diagram of various frames of a neural electronic chip according to an embodiment of the present invention

6 is a block diagram of a neural electronic chip using a collagen tube with one end closed according to an embodiment of the present invention

7 is a diagram illustrating the connection between the cut nerves using the nerve electronic chip according to an embodiment of the present invention

8: Schematic diagram of the nerve contact of the nerve electronic chip according to an embodiment of the present invention

9: Schematic diagram of the many-to-one nerve contact of a neural electronic chip according to an embodiment of the present invention

10: Schematic diagram of the one-to-many nerve contact of a neural electronic chip according to an embodiment of the present invention

11 is a schematic diagram of a nerve contact having side silicon of a neural electronic chip according to an embodiment of the present invention;

12 is a schematic diagram of a neural contact having a lateral field effect transistor of a neural electronic chip according to an embodiment of the present invention.

13 is a circuit diagram illustrating the measurement of neural contacts of a neural electronic chip according to an embodiment of the present disclosure;

14 is a circuit diagram illustrating the measurement of nerve contacts of a nerve electronic chip according to another embodiment of the present invention.

Fig. 15 is a circuit diagram illustrating the stimulation of neural contacts of a neural electronic chip according to Embodiment A of the present invention.

16 is a circuit diagram illustrating the stimulation of neural contacts of a neural electronic chip according to Example B of the present invention.

Fig. 17 is a circuit diagram illustrating the stimulation of neural contacts of a neural electronic chip according to Embodiment C of the present invention.

18 is a circuit diagram illustrating the stimulation of neural contacts of a neural electronic chip according to Example D of the present invention.

Fig. 19 is a circuit diagram illustrating the stimulation of neural contacts of a neural electronic chip according to Embodiment E of the present invention.

20 is a circuit diagram illustrating the measurement and stimulation of neural contacts of a neural electronic chip according to a switched type embodiment of the present invention.

21 is a circuit diagram illustrating the measurement and stimulation of nerve contacts of a neural electronic chip according to a standalone embodiment of the present invention.

22 is a block diagram illustrating a neural electronic chip according to an embodiment of the present invention.

Fig. 23 is a block diagram showing the configuration of a row driver and a column driver of a neural electronic chip according to a switched embodiment of the present invention.

24 is a block diagram illustrating the configuration of a row driver and a column driver of a neural electronic chip according to a standalone embodiment of the present invention.

<Description of Symbols Used in Main Parts of Drawing>

10: bulk silicon 11: source

12: drain 13: culture medium

14: brain cells

100: nerve 110: nerve fiber

120: suture

200: collagen tube 210: collagen material

300: neural electronic terminal 310: field effect transistor (FET)

311: side silicon 312: side FET

320: silicon 330: source

331: side source 340: drain

341: side drain 350: film

360: current output 363: side current output

370: grounding conductor

380: electrical stimulation (drive) signal 381: side electrical stimulation signal

390: excitation point 395: switch

400: Neural Computer Chip 410: Layers

411: top layer 420: driver controller

430: Row driver 431: Row access

440: column driver 441: stimulus signal

442: switch signal 450: column amplifier

451: column multiplexer

452: Gain 453: Analog-to-Digital Converter

454: line driver 455: current / voltage converter

460: bios generator

461: clock generator 462: oscillator

470: stimulus signal 471: request signal

472: nerve signal

500: frame 501: suture hole

510: I / O pin 520: transceiver

530: connecting cable

The present invention relates to a neural electronic chip using a field effect transistor, the collagen tube 200 is penetrated between the nerve fibers 110 of the nerve 100 at the end of the nerve 100 consisting of the nerve fibers 110, 200 And, located at the end of the nerve fiber 110, attached to contact with the collagen tube 200, consists of a source 330 and drain 340 formed on the silicon 320, the nerve signal measurement function In the case of having a current can be output to the current output 360 by using the electric field formed at the end of the nerve fiber 110 as a drive signal, and having a nerve stimulation function to the potential across the source 330 and the drain 340 A neural electronic terminal 300 having a field effect transistor (FET) 310 for transmitting an electrical stimulus signal to the neural fiber 110 by an electric field generated by the electric field, and the neural electronic terminal 300. Install this And a frame 500 coupled to the neuron and collagen tube 200 and the suture unit 120 and installed on the frame 500 and connected to the array of the field effect transistor 310. In the case of having a function of stimulating the nerve 100, the electric field effect transistor 310 is controlled and driven by the stimulus signal 470 to generate an electric field for stimulating the end of the nerve fiber 110. In case of having a function of measuring a neurotransmitter electrical signal of the nerve 100, an analog / digital converter for converting the current output 360 of each field effect transistor 310 into a digital signal and outputting a nerve signal 472 Neural computer chip 400 composed of 453 and the frame 500, the input and output of the stimulus signal 470 and the nerve signal 472 of the neural computer chip 400, the external device Connectable Mouth / Relates to a neural electronic chip characterized in that the configuration including the output pin 510.

In general, when the nerve of the living body is cut or damaged, to some extent it is possible that the nerve cells are connected again in the recovery phase by the natural healing power of the nerve cells, and the nerve signals related to the senses or movements can be transmitted again. In addition, even when the cut nerve is re-bonded through a surgical operation or the like, the nerve cells are connected again, so that the nerve signals related to the senses or the movement may be transmitted again.

However, if the damage site is extensive or the distance between the damaged nerves is so large that it is impossible to connect them by surgical methods, it is possible to repair and repair the surrounding skeleton, muscles, and blood vessels. It is not possible to lose the sense of the site, as well as to recover the athletic ability, there was a problem that left an unrecoverable disorder in the end.

In order to overcome this problem, until now, a method of measuring an electric signal of a nerve or applying an electrical stimulus to the nerve has been generally used. Most of these electrodes have a probe shape, and one or more thin and sharp probes have been used. However, this conventional method has a problem in that pathological problems such as necrosis or infection occur due to the physical shape and size of the electrode installed in direct contact with or penetrating the nerve. In addition, due to the limitation of the physical size of the electrode (no matter how small, up to 100 electrodes (probe) per 65 square mm to date) it is not a terminal nerve cell, but a bundle of nerve fibers, such as the spinal cord, each nerve fiber In the case of nerves that transmit other nerve signals, it is practically impossible to install electrodes in each of the nerve cell stems that make up the nerves. There was a problem that the method is not applicable.

 In order to overcome this problem, when a signal is transmitted from a brain cell having almost the same properties as a nerve, the nerve signal is transmitted by a change in an electric field around the nerve. As shown, a method of amplifying and measuring a neural signal into an electrical signal using a field effect transistor (FET) has been studied. In this case, after dipping the brain cells 14 into the culture medium 13 as shown in FIG. 1, the field effect transistor composed of the source 11 and the drain 12 formed on the bulk silicon 10 under the culture medium. A method of amplifying and measuring neural signals transmitted from the brain cells 14 using (FET) has been studied. However, even in this method, because it is a configuration for the study of brain cells, it is difficult to measure or stimulate a large amount of various and various kinds of signals at a time, which is composed of several neurofibers (110) strands, and brain cells at once. (14) is a structure floating in the culture medium (13) and there is no way to accurately fix the brain cells 14, in particular, due to the nature of the many bundles of nerves (100) to measure or stimulate the nerve signal is accurate and unchanged over time Difficult to do, and in addition to the structure using the culture medium, there is a problem that unlike the collagen material, the survival and stable supply of brain cells is also difficult.

The present invention has been made to solve the above problems, and relates to a neural electronic chip using a field effect transistor, the nerve fibers of the nerve (100) at the end of the nerve (100) consisting of nerve fibers (110) And a source 330 formed on the silicon 320 and penetrated through the collagen tube 200 and attached to the collagen tube 200 at the end of the nerve fiber 110. Comprising a drain 340, when having a nerve signal measuring function can output the current output 360 by using an electric field formed at the end of the nerve fiber 110 as a drive signal, the source when the nerve stimulation function A nerve in which a field effect transistor (FET) 310 for transmitting an electrical stimulus signal to the nerve fiber 110 is arranged as an electric field generated by the potential applied to the 330 and the drain 340. The electronic terminal 300 and the neural electronic terminal 300 is installed, the frame 500 is coupled to the nerve cells and collagen tube 200 and the suture 120, and on the frame 500 And a stimulus signal 470 to control and drive each of the field effect transistors 310 when connected to an array of the field effect transistors 310 and having a function of stimulating the nerves 100. When generating an electric field for stimulating the end of the fiber 110, and having the function of measuring the neurotransmission electrical signal of the nerve 100, the current output 360 of each field effect transistor 310 is digital A neural computer chip 400 composed of an analog-to-digital converter 453 that converts the signal into a signal and outputs a neural signal 472, and a stimulus signal of the neural computer chip 400 installed in the frame 500. Nerves with 470 It provides a neural electronic chip, characterized in that it comprises an input / output pin 510 that can connect the input / output of the arc 472 to an external device, and has a stable structure at the end of the nerve fiber damaged by cutting or the like By mounting a neural electronic chip, a nerve signal transmitted from a nerve may be measured as an electrical signal, and an electrical stimulation signal may be transmitted to a nerve fiber to be transmitted as a nerve signal.

In order to achieve the above object, the present invention is a collagen tube 200 is penetrated between the nerve fiber 110 of the nerve 100 to the end of the nerve 100 made of the nerve fiber 110, and the nerve Located at the end of the fiber 110, attached to contact with the collagen tube 200, and consists of a source 330 and a drain 340 formed on the silicon 320, if the nerve signal measurement function The current output 360 may be output by using an electric field formed at the end of the nerve fiber 110 as a driving signal, and in the case of having a nerve stimulation function, an electric field generated by a potential applied to the source 330 and the drain 340. And a neural electronic terminal 300 having a field effect transistor (FET) 310 for transmitting an electrical stimulation signal to the neural fiber 110, and the neural electronic terminal 300. The neurons and cola The frame 500 coupled to the tube 200 and the suture 120 and the frame 500 are installed on the frame 500 and connected to the array of the field effect transistor 310 to stimulate the nerve 100. In the case of having a function, the field effect transistors 310 are controlled and driven by the stimulus signal 470 to generate an electric field for stimulating the ends of the nerve fibers 110, and the nerve transmission of the nerves 100. In the case of having an electric signal measuring function, a nerve composed of an analog / digital converter 453 converting the current output 360 of each field effect transistor 310 into a digital signal and outputting a neural signal 472. An input / output installed on the computer chip 400 and the frame 500 and capable of connecting an input / output of the stimulus signal 470 and the neural signal 472 of the neural computer chip 400 to an external device. Configured to include a pin 510 And that is characterized.

In addition, the silicon 320 is characterized in that it further comprises a side silicon 311 formed to extend to the side of the nerve fiber (110).

In addition, it is characterized in that it further comprises a side field effect transistor 312 consisting of a side source 331 and a side drain 341 formed on the side silicon 311.

In addition, in addition to the source 330 and the drain 340 constituting the field effect transistor (FET) (310) is formed on the silicon 320, transferred from the neural computer chip (400) A magnetic pole point 390 having a function of transmitting a stimulus signal to the nerve fiber 110 by an electric field generated by a potential applied by the electrical stimulation signal 380 between the ground electrode and the ground electrode by the stimulus signal 470. It is characterized in that it further comprises.

In addition, the electric field is formed on the side silicon 311, the electric field generated by the potential applied by the electrical stimulation signal 380 between the ground electrode and the stimulus signal 470 transmitted from the neural computer chip 400 To the nerve fiber 110 is characterized in that it further comprises a side stimulation point (not shown) having a function of transmitting a stimulus signal.

In addition, the interval between the nerve fiber 110 end and the field effect transistor (FET) 310 is characterized in that 0 ~ 200nm.

In addition, the film 350 may be inserted between the end of the nerve fiber 110 and the field effect transistor (FET) 310.

In addition, the nerve fiber 110 and the field effect transistor (FET) 310 are disposed corresponding to one-to-one (1: 1), one-to-many (1: m) or many-to-one (n: 1). It is characterized by.

In addition, the neural computer chip 400 is connected to a secondary array of the field effect transistor 310 to stimulate a row driver 430 and a column driver 440 for driving the field effect transistor 310. A driver generator 420 controlled by the controller 470, a clock generator 461 connected to the row driver 430 and generating a clock signal for driving the bios generator 460 connected to the oscillator 462; A current / voltage converter 455 attached to each output of the field effect transistor 310, a thermal amplifier 450 connected to the current / voltage converter 455 to amplify a voltage output signal, and the thermal amplifier A thermal multiplexer 451 connected to the 450 to control and transmit a signal of a plurality of lines, and an analog / digital converter 453 that outputs a neural signal 472 by converting an output of the thermal multiplexer 451 into a digital signal; ) Characterized in that it comprises a.

In addition, the column driver 440 may generate a switch signal 442 that selects a neural signal measuring function and a neural stimulation function, and outputs a current to the field effect transistor 310 by the switch signal 442. It further comprises a switch 395 that can selectively connect the 360 or the electrical stimulation signal 380.

In addition, the suture 120 is characterized in that the suture using a surgical suture or surgical suture adhesive.

In addition, the collagen tube 200 is characterized in that consisting of polyglycolic acid collagen (Polyglycolic acid Collagen).

In addition, the collagen material 210 is characterized in that the interior of the collagen tube 200 is penetrated between the nerve fibers 110 of the nerve 100.

In addition, the collagen material 210 is characterized in that consisting of laminin-coated collagen fibers (Laminin-coated collagen fibers).

On the other hand, the collagen tube 200 has only one open pocket shape, the frame 500 is attached to the transmitting and receiving device 520 that can transmit the input / output signal of the neural computer chip 400 to the outside It is characterized by.

In addition, the frame 500 is characterized in that the suture hole 501 is formed so that the suture thread passes easily.

In addition, the electrical stimulation signal that the field effect transistor 310 transmits to the nerve fiber 110 is characterized in that it gives a signal once with a voltage of 1 ~ 10V.

In addition, the electrical stimulation signal transmitted from the field effect transistor 310 to the nerve fiber 110 is characterized in that the signal is given once at a voltage of 5V.

In addition, the electrical stimulation signal that the field effect transistor 310 transmits to the nerve fiber 110 is characterized in that the pulse of the 1 ~ 10V voltage repeatedly signals 10 to 200 times at intervals of 10 to 30μs.

In addition, the pulse of the electrical stimulation signal transmitted by the field effect transistor 310 to the nerve fiber 110 is characterized in that the pulse width of 20μs.

In addition, the pulse of the electrical stimulation signal transmitted by the field effect transistor 310 to the nerve fiber 110 is applied to a voltage of 5V 50 times.

In addition, the pulse of the electrical stimulation signal transmitted by the field effect transistor 310 to the nerve fiber 110 is characterized in that 100 times applied to a voltage of 5V.

Hereinafter, a neural electronic chip using a field effect transistor according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings. First, in the drawings, the same components or parts are to be noted that as indicated by the same reference numerals as possible. In describing the present invention, detailed descriptions of related well-known functions or configurations are omitted in order not to obscure the subject matter of the present invention.

The neural electronic chip using the field effect transistor of the present invention, as shown in Figure 2 collagen tube 200, neural electronic terminal 300, neural computer chip 400, frame 500 and input / output pins 510 It is composed of

First, the collagen tube 200 will be described. The collagen tube 200 is attached to the nerve 100 by the suture 120 as shown in FIG. In this case, the collagen tube 200 has a function of physically fixing the nerve 100 and the neural computer chip 400 to be described later. On the other hand, the collagen material 210 is applied or filled on the inner surface of the collagen tube 200 is made of nerve fibers 110, as shown in Figure 3 due to the characteristics of the material excellent in semi-fluidity and permeability and tissue intimacy It is possible to penetrate between the nerve fibers 110 of the nerve 100 at the end of the (100) to enable a stable attachment of the collagen tube 200 and the nerve (100). And at the same time to provide a smooth nutrition of the wounded nerves at the same time, to help the recovery to prevent the necrosis of the nerves, to help the nerve fibers closer to the nerve electronic terminal 300, the nerve fiber 110 is even, strongly Help connect Therefore, the nerve 100 and the field effect transistor 310 to be described later are tightly adhered to each other to maintain a constant positional relationship to maintain good performance, and the nerve and the neural computer chip 400 to be described later are external shocks or motions. It can prevent falling by preventing the signal change over time and maintain the same input / output resolution. In addition, the collagen tube 200 virtually eliminates the rejection of the human or animal body against the neural computer chip 400 and the frame 500, thereby preventing hardening, fat accumulation, or film formation. In this case, the suture unit 120 may be sutured using a surgical joint as shown in FIG. 3, or may be sutured using an adhesive for surgical suture. On the other hand, the shape of the collagen tube 200 can vary the length and diameter according to the shape of the nerve and the shape of the neural computer chip 400 and the frame 500.

On the other hand, the collagen tube 200 may both have an open form or only one open form. As shown in FIG. 6, when the collagen tube 200 has only one open pocket shape, the frame 500 to be described later may transmit and receive an input / output signal of the neural computer chip 400 to be described later. It is also possible to attach the device 520 to use the neural electronic chip of the present invention in vivo without a separate connection line.

The collagen tube 200 is made of polyglycolic acid collagen in order to actively generate nerve growth, thereby helping the growth of the cut surface of the nerve 100, the nerve fiber 110 and the electric field effect to be described later It is desirable to make the spacing closer to the transistor 310 and to provide almost the same environment for each of the nerve fibers of the nerve cutting plane, so that the nerve sprouts are nearly equal in distance to the field effect transistor 310. To control the signal. In addition, the collagen material 210 is more preferably made of laminin-coated collagen fibers.

Next, the neural electronic terminal 300 will be described. The neural electronic terminal 300 is located at the distal end of the nerve fiber 110, as shown in Figure 2 is attached to contact with the collagen tube 200. The neural electronic terminal 300 has a field effect transistor (FET) 310 to be described later. Meanwhile, the neural electronic terminal 300 may be formed on a semiconductor wafer by forming a layer (layer) with the neural computer chip 400 to be described later. Since a technique for manufacturing the neural electronic terminal 300 by forming a circuit with such a field effect transistor on a semiconductor wafer is well known in the art to which the present invention pertains, a detailed description thereof will be omitted.

Next, a field effect transistor (FET) 310 will be described. The field effect transistor (FET) 310 is formed of a source 330 and a drain 340 formed on the silicon 320 as shown in FIG. 13. When the nerve signal transmitted from the nerve fiber 110 is to be measured using the neural electronic chip of the present invention, when the nerve signal propagates to the nerve fiber 110, a potential difference occurs at the end of the nerve fiber, and thus This results in an electric field. A channel through which a current can flow is formed in the silicon 320 between the source 330 and the drain 340 constituting the field effect transistor (FET) 310 in proportion to the intensity of the electric field, As a result, as shown in FIG. 13, a current output 360 is possible that is proportional to the neural signal transmitted from the neural fiber 110. In this case, the source 330 and the drain 340 may be made of P-type silicon, the silicon 320 may be made of N-type silicon, and the source 330 and the drain 340 may be made of N−. The silicon may be made of type silicon, and the silicon 320 may be made of P-type silicon.

In this case, a film 350 having insulation for insulation between the source 330 and the drain 340 and the silicon 320 and the nerve fiber constituting the field effect transistor (FET) 310. It is preferable to insert the film 350, and the film 350 may be manufactured together with the insulating film in a semiconductor process of manufacturing the field effect transistor 310. In this case, it is possible to form the SiO2 film generally used for insulation or to form the TiO2 film.

Meanwhile, as shown in FIG. 11, the silicon 320 may be processed by the silicon 320 to form side silicon 311 which may be in contact with the side surface of the nerve fiber 110. It is desirable to position the silicon 320 more stably. In this case, the independence of the signal transmitted from the nerve fiber 110 increases. In addition, as shown in FIGS. 12 and 14, 16, and 18, the side field effect transistor 312 including the side source 331 and the side drain 341 formed on the side silicon 311 may be formed. It may be configured to further include, so that not only the terminal but also the side of the nerve fiber 110 can measure the nerve signal or transmit a nerve stimulation signal.

The field effect transistor 310 may be formed at a position corresponding to the nerve fiber 110 one-to-one (1: 1) as shown in FIG. 8, but in general, one or more nerve fibers 110 may be formed. Considering the property of delivering the same neural signal in a bundle, the nerve fiber 110 and the field effect transistor 310 are many-to-one (n: 1, where n is an integer of 2 or more, as shown in FIG. 9). It is possible to form at a position corresponding to).

In addition, by measuring the signal transmitted from one of the nerve fiber 110 using a plurality of field effect transistor 310, the nerve fiber so that the signal transmitted from the nerve fiber 110 can be measured more precisely It is possible to form the 110 and the field effect transistor 310 at positions corresponding to one-to-many (1: m, where m is an integer of 2 or more) as shown in FIG.

On the other hand, in the case of using the neural electronic chip of the present invention to transmit the electrical stimulation to the nerve fiber 110, as shown in Figure 13 by the electrical stimulation signal 380 and the source (330) and drain ( An electric potential difference occurs between the source 330 and the drain 340 as shown in FIG. 15, or a potential difference is generated between the ground electrode 340 and the ground electrode. The stimulus signal is transmitted to 110.

Substantially, a circuit configuration in the case of measuring a nerve signal from the nerve fiber 110 or transmitting a nerve stimulation signal to the nerve fiber 110 using the field effect transistor 310 is schematically represented. It has a configuration equivalent to that of the circuit represented by 20. (This case is referred to as " switched type " hereinafter.) That is, the neural signal from the nerve fiber 110 using the field effect transistor 310. In order to measure, the switch 395 shown in FIG. 20 is connected to the measurement circuit below, and the source 330 and the drain 340 are formed by an electric field generated by a neural signal transmitted from the nerve fiber 110. Outputs a current output 360 flowing between. Meanwhile, when the nerve stimulation signal is transmitted to the nerve fiber 110 by using the field effect transistor 310, the switch 395 shown in FIG. 20 is connected to an upper stimulation circuit to connect the electric stimulation signal 380. By transmitting the neural signal to the nerve fiber 110 by the electric field formed in the field effect transistor (310). Meanwhile, the switch 395 illustrated in FIG. 20 may be configured to include the function of the switch 395 in a circuit of the neural computer chip 400 to be described later.

In addition, as illustrated in FIG. 19 or 21, a magnetic pole point 390 capable of transmitting an electrical stimulation signal 380 to the nerve fiber 110 is provided separately from the source 330 or the drain 340. Formed on the silicon 320 to generate a potential difference between the magnetic pole point 390 and the ground electrode by the electrical stimulation signal 380, and an electric field is formed by the potential difference to form the nerve fiber 110. It is also possible to transmit a stimulus signal to When the separate magnetic pole points 390 are formed in this way, as shown in FIG. 21, it is possible to configure a circuit in which the current measurement 360 and the electrical stimulation signal 380 are independent of each other. As shown in FIG. 24, the neural computer chip 400 to be described later does not need to apply a separate switch signal 442. (This case is referred to as " standalone " hereinafter.)

 In such a case, when the field effect transistor 310 is configured such that only the magnetic pole point 390 is formed without the source 330 or the drain 340 as shown in FIG. 19, the nerve fiber ( Rather than measuring the neural signal transmitted at 110, it may be considered to simplify the fabrication process if only the function of stimulating the nerve fiber 110 is needed.

In this case, the electrical stimulation signal transmitted by the field effect transistor 310 to the nerve fiber 110 by the electrical stimulation 380 may be considered in various ways depending on the type or environment of the nerve cells and the characteristics of the signal to be applied. However, giving a signal once with a voltage of 1 ~ 10V can be basically considered. In this case, it is preferable that the electrical stimulus 380 transmitted by the field effect transistor 310 to the nerve fiber 110 gives a signal at a voltage of 5V. On the other hand, the electrical stimulation 380 transmitted by the field effect transistor 310 to the nerve fiber 110 may be considered to repeatedly signal the pulse of 1 ~ 10V voltage 10 to 200 times at intervals of 10 ~ 30μs. In this case, it is preferable that the pulse of the electrical stimulation signal transmitted from the field effect transistor 310 to the nerve fiber 110 has a pulse width of 20 μs. In addition, the pulse of the electrical stimulation signal transmitted by the field effect transistor 310 to the nerve fiber 110 is preferably applied 50 times or 100 times with a voltage of 5V.

Next, the neural computer chip 400 will be described. The neural computer chip 400 is installed on the frame 500 as shown in FIG. 2, and is connected to the array of the field effect transistor 310 to stimulate the nerve 100. Each field effect transistor 310 is controlled and driven by a stimulus signal 470 to generate an electric field for stimulating the distal end of the nerve fiber 110, and to measure a neurotransmitter electrical signal of the nerve 100. In the case of having a function, the current output 360 of each field effect transistor 310 is converted into a digital signal, and an analog / digital converter 453 outputs a neural signal 472. In more detail, the configuration of the neural computer chip 400 is connected to the two-dimensional array of the field effect transistor 310 as schematically illustrated in FIG. A driver controller 420 controlling the row driver 430 and the column driver 440 driving the 310 by a stimulus signal 470, and connected to the row driver 430 and connected to the oscillator 462. A clock generator 461 for generating a clock signal for driving the bios generator 460, a current / voltage converter 455 attached to each output of the field effect transistor 310, and the current / voltage converter 455 A thermal amplifier 450 connected to the amplified voltage output signal, a thermal multiplexer 451 connected to the thermal amplifier 450 to control and transmit a signal of a plurality of lines, and the thermal multiplexer 451. And an analog / digital converter 453 for converting the output of the digital signal into a digital signal and outputting the neural signal 472.

The neural computer chip 400 may output a signal such as that shown in more detail in FIG. 23 when the field effect transistor 310 is "switched" as shown in FIG. 20. Input / output to 310. That is, the row driver 440 constituting the neural computer chip 400 outputs a stimulus signal 441 to the field effect transistor 310 to function as an electrical stimulation signal 380. The current output 360 from the input to the current / voltage converter 455. The row driver 440 outputs a switch signal 442 to drive the switch 395 that selects the measurement function and the stimulation function of the field effect transistor 310. For example, when the switch signal 442 is " 1 " (High Voltage), the switch 395 is connected to drive the circuit having the upper stimulus function in FIG. 20, and the stimulus function is selected. If the signal 442 is "0" (Low Voltage or Ground) it is possible for the switch 395 to be connected to drive the circuit having the lower measuring function in FIG. 20 so that the measuring function is selected.

Meanwhile, the neural computer chip 400 is more specifically illustrated in FIG. 24 when the field effect transistor 310 is the above-described " independent " having the magnetic pole point 390 as shown in FIG. A signal such as one is input / output to the field effect transistor 310. In this case, unlike the case of the "switched type" described above, it does not require a separate switch signal 442, it is possible to control the measurement function and the stimulation function independently.

The neural computer chip is configured / manufactured to integrate all the functions into one chip to minimize the size by using the concept of a system on chip (SOC), when the neural electronic chip of the present invention is mounted on the inside of the body, etc. It is preferable to minimize the burden on the body and to minimize side effects. The technology for constructing such a neural computer chip is a technology that processes signals transmitted from a plurality of arranged sensors in a CCD camera or the like, or processes signals transmitted to a plurality of devices as in the case of a driving circuit of a display panel. In the general field of electronic engineering or the field to which the present invention pertains, it is obvious or belongs to a known technology, and thus detailed description thereof will be omitted.

Next, the frame 500 will be described. The frame 500 has a function of a structural unit for coupling and supporting each component of the neural electronic chip of the present invention, the neural computer chip 400 is installed as shown in Figure 2, the nerve cells and collagen It is coupled to the tube 200 and the suture 120. In the case of using the surgical suture to the suture unit 120, the frame 500 is preferably such that the suture hole 501 is formed as shown in FIG. The shape of the frame 500 and the shape and arrangement of the suture hole 501 increases the adhesion between the collagen tube 200 and the nerve 100 as shown in FIGS. 4 and 5, and increases the strength. It is possible to have various shapes and arrangements to increase. In addition, the frame 500 may use a variety of materials to reduce the rejection of the living body.

Next, the input / output pin 510 will be described. The input / output pin 510 is installed in the frame 500, and may connect the stimulus signal 470 of the neural computer chip 400 and the input / output of the neural signal 472 to an external device. Has the function.

 The input / output pin 510 is preferably provided with a standardized pin to enable a flexible and various expansion through external devices. Meanwhile, in order to reduce space and a special function, an external device may be used as an independent integrated device instead of the input / output pin 510, or a transceiver 520 for wireless or wired connection may be integrated. In addition, the input / output pin 510 may be attached to a wireless or wired or completed socket, or an experimental device.

Hereinafter, the operation of the neural electronic chip using the field effect transistor according to an embodiment of the present invention will be described.

First, a process of measuring neural signals transmitted from the nerve 100 using the neural electronic chip will be described. When a nerve signal propagates through the nerve fiber 110 composed of the nerve 100, a potential difference occurs at the end of the nerve fiber, and thus an electric field is generated. A channel through which a current can flow is formed in the silicon 320 between the source 330 and the drain 320 constituting the field effect transistor (FET) 310 in proportion to the strength of the electric field, As shown in FIG. 13 or FIG. 14, a result is a current output 360 that is proportional to the neural signal transmitted from the neural fiber 110. Current outputs output from one or more field effect transistors 310 are converted into voltage signals through a current / voltage converter 455 or the like in a circuit inside the neural computer chip 400, and each of these voltage signals is converted into the neural signals. The computer chip 400 processes and outputs a digitized measurement signal.

On the other hand, in the case of using the neural electronic chip of the present invention to transmit the electrical stimulation to the nerve fiber 110, first the stimulus signal 470 input to the neural computer chip 400, the neural computer chip 400 This processing delivers the electrical stimulus signal 380 to one or more respective field effect transistors 310. A potential difference is generated between the source 330 and the drain 340 by the electrical stimulation signal 380, and an electric field is formed by the potential difference to transmit a stimulus signal to the nerve fiber 110. .

Applying this operation process, as shown in Figure 7, the neural electronic chip of the present invention is installed on one end of the cut nerve (neural electronic chip A) and another neural electronic chip (neural electronic chip B) is cut After being installed at the corresponding end of the nerve, the measurement signal of the neural electronic chip A is transmitted as the stimulus signal of the neural electronic chip B, and on the contrary, the measurement signal of the neural electronic chip B is transmitted as the stimulation signal of the neural electronic chip A. An operation is possible that allows nerve signals to be communicated with each other as the cut nerves are connected.

In the foregoing description, optimal embodiments have been disclosed in the drawings and the specification. Although specific terms have been used herein, they are used only for the purpose of describing the present invention and are not used to limit the scope of the present invention as defined in the meaning or claims. Therefore, those skilled in the art will understand that various modifications and equivalent other embodiments are possible. Therefore, the true technical protection scope of the present invention will be defined by the technical spirit of the appended claims.

As described above, according to the present invention, the nerve signal transmitted from the nerve can be measured as an electrical signal by mounting a nerve electronic chip at the end of the nerve fiber damaged by cutting, etc., and the electrical stimulation signal is transmitted to the nerve fiber by It can be transmitted as a nerve signal has the advantage that the nerve signal can be transmitted even if the nerve is damaged.

In particular, compared to existing methods and devices, nerve damage or necrosis can be greatly prevented, and since the FET using semiconductor technology is used, the size of each FET performing the function of an electrode (probe) in the conventional method is large. Significantly miniaturized compared to electrodes (probes), it is possible to connect nerve fibers and FETs 1: 1 (1: n, n: 1 depending on the need), and each FET accurately measures the nerve signal Has the advantage that it is significantly improved compared to the conventional electrode (probe). In addition, since the signal is digitalized in the chip and sent out of the chip, almost intact information can be obtained.

 In addition, nerve fibers and electronics are connected 1: 1 and transmit signals, so that they can send and receive precise information compared to the device in the past, and are naturally connected to the body, so that the body of the body is more than the past device without training. You can feel the same control, and you can feel the same senses (senses, muscle feedback, etc.) that you feel with your body.

In the case of hearing, even if a cochlear implant, which is currently in practical use, cannot be used (such as a snail malformation), if only a nerve is connected to the brain, it may be possible to recover hearing using the present invention. It can also give more sophisticated cues than current cochleas, making it more likely to sound like a real ear to a deaf person.

  On the other hand, in the case of vision, the artificial retina (silicon retina) currently being studied is actually planted in the human body and is being studied, but there is a problem in that it cannot transmit a signal due to the low resolution. However, according to the present invention, the nerve fiber and the FET are connected 1: 1 (1: n, m: 1 depending on necessity) to transmit signal information directly to the nerve, so that information similar to that of the real eye is seen. Can pass.

On the other hand, if the present invention is applied to the end of the nerves or the central nerve (brain, spinal cord, etc.) when connected to a mechanical device such as a car, wheelchair, computer, it may be possible to control the device through the nerve information, virtual world If you connect all the nerves such as sight, hearing, smell, taste, muscles (including the eye muscles), there is an advantage that it is possible to live in virtual reality almost like reality.

        In addition, in various biotechnology-related experiments and studies, signals from the central nerve can be read out in units of nerve fibers, so that accurate signals with high resolution can be read out and various experiments can be performed while sending signals to the nerves. In this case, nerve fibers can be sent to the central nervous system, which has the advantage of being able to send high-precision signals.

Claims (19)

A collagen tube 200 infiltrated and attached between the nerve fibers 110 of the nerve 100 at the end of the nerve 100 consisting of the nerve fibers 110; Located at the distal end of the nerve fiber 110, attached to contact with the collagen tube 200, consists of a source 330 and a drain 340 formed on the silicon 320, and has a nerve signal measurement function In this case, the current output 360 may be output by using the electric field formed at the end of the nerve fiber 110 as a driving signal, and when the nerve stimulation function is generated, it is generated by the potential across the source 330 and the drain 340. A neural electronic terminal 300 in which a field effect transistor (FET) 310 for transmitting an electrical stimulation signal to the neural fiber 110 is arranged; The nerve electronic terminal 300 is installed, the frame 500 is coupled to the nerve 100 and the collagen tube 200 and the suture 120; When installed on the frame 500 and connected to the array of the field effect transistor 310 and having a function of stimulating the nerve 100, each field effect transistor 310 is provided by a stimulus signal 470. Control and drive) to generate an electric field to stimulate the ends of the nerve fibers 110, In the case of having a function of measuring a nerve transmission electrical signal of the nerve 100, the analog / digital outputting the nerve signal 472 by converting the current output 360 of each field effect transistor 310 into a digital signal A neural computer chip 400 comprised of a transducer 453; An input / output pin 510 installed in the frame 500 and configured to connect an input / output of the stimulus signal 470 and the neural signal 472 of the neural computer chip 400 to an external device; Neural electronic chip, characterized in that comprising a. The method according to claim 1, The silicon 320 may include side silicon 311 extending to the side of the nerve fiber 110; Neuron electronic chip, characterized in that further comprises. The method according to claim 2, A side field effect transistor (312) comprising a side source (331) and a side drain (341) formed on the side silicon (311); Neural electronic chip, characterized in that further comprises. The method according to claim 1, A stimulus formed on the silicon 320 in addition to the source 330 and the drain 340 constituting the field effect transistor (FET) 310, and transmitted from the neural computer chip 400. A stimulus point 390 having a function of transmitting a stimulus signal to the nerve fiber 110 by an electric field generated by a potential applied according to the electrical stimulation signal 380 between the ground electrode and a signal 470; Neuron electronic chip, characterized in that further comprises. The method according to claim 2 or 3, The electric field is formed on the side silicon 311 and is generated by a potential applied by the electrical stimulation signal 380 between the ground electrode and the electrical signal by the stimulus signal 470 transmitted from the neural computer chip 400. A lateral stimulus point (not shown) having a function of transmitting a stimulus signal to the nerve fiber 110; Neuron electronic chip, characterized in that further comprises. The method according to any one of claims 1 to 3, Neural electronic chip, characterized in that the interval between the nerve fiber 110 and the field effect transistor (FET) 310 is 0 ~ 200nm. The method according to claim 6, The nerve electronic chip, characterized in that the film (350) is inserted between the end of the nerve fiber (110) and the field effect transistor (FET) (310). The method according to claim 7, The nerve fiber 110 and the field effect transistor (FET) 310 are one-to-one (1: 1) or one-to-many (1: m where m is an integer of 2 or more) or many-to-one (n: 1 where n is an integer of 2 or more) correspondingly arranged. The method according to claim 8, The neural computer chip 400, A driver controller 420 connected to the two-dimensional array of the field effect transistor 310 to control the row driver 430 and the column driver 440 that drive the field effect transistor 310 by the stimulus signal 470. ) ;, A clock generator 461 connected to the row driver and generating a clock signal for driving the bios generator 460 connected to the oscillator 462; A current / voltage converter 455 attached to each output of the field effect transistor 310; A thermal amplifier (450) connected to the current / voltage converter (455) to amplify a voltage output signal; A thermal multiplexer 451 connected to the thermal amplifier 450 to control and transmit a signal of a plurality of lines; An analog / digital converter 453 for converting the output of the thermal multiplexer 451 into a digital signal and outputting a neural signal 472; Neural electronic chip, characterized in that comprising a. The method according to claim 9, The column driver 440 may generate a switch signal 442 for selecting a nerve signal measuring function and a nerve stimulating function. A switch 395 for selectively connecting a current output 360 or an electrical stimulation signal 380 to the field effect transistor 310 by the switch signal 442; Neural electronic chip, characterized in that further comprises. The method according to claim 9, The suture unit 120 is a nerve electronic chip, characterized in that the suture using a surgical suture or surgical suture adhesive. The method according to claim 9, The electrical stimulation signal transmitted from the field effect transistor 310 to the nerve fiber 110 is a neural electronic chip, characterized in that it repeatedly signals a pulse of a voltage of 1 ~ 10V at 10-30μs interval 10 to 200 times . The method according to claim 1, The collagen tube 200 is a neuron electronic chip, characterized in that made of Polyglycolic acid Collagen (Polyglycolic acid Collagen). The method according to claim 13, The neuron chip of the collagen tube 200, characterized in that the collagen material 210 is penetrated between the nerve fibers (110) of the nerve (100). The method according to claim 1, The collagen tube 200 has only one open pocket shape, and the frame 500 is attached with a transceiver 520 capable of transmitting an input / output signal of the neural computer chip 400 to the outside. Nerve electronic chip. The method according to claim 1, The frame 500 is a nerve electronic chip, characterized in that the suture hole 501 is formed so that the suture thread passes easily. The method according to claim 1, The neural computer chip 400 is a neural electronic chip, characterized in that made of a planar semiconductor chip that can be attached to the frame 500 in a plane. The method according to claim 17, The neural electronic terminal 300 is a neural electronic chip, characterized in that made of a planar semiconductor chip formed by forming a layer (Layer) with the neural computer chip (400). The method according to claim 14, The collagen material 210 is a neuron electronic chip, characterized in that made of laminin-coated collagen fibers (Laminin-coated collagen fibers).

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