KR100758556B1 - Iontophoretic drug delivery system - Google Patents

Abstract

The present invention relates to an ion drug delivery system for penetrating various chemicals into the mucosal tissues of teeth and gums by iontophoresis, and more particularly, a power supply device having a ground electrode, In the drug introduction device using the iontophoretic method consisting of an ion tray having an end portion formed in the "U" shape and the electrode is provided in close contact with the teeth and gums in the form of the site to be treated, the ion tray In order to maintain a close contact with the gums, a "U" shaped outer shell made of soft and elastic silicone rubber, a metal electrode located on the inner bottom surface of the outer shell, and placed inside the outer shell "U" shaped padding type made of polyester material with high absorption capacity and shape retention It is composed of endothelial relates to a medical drug ion introduction unit, it characterized in that it is such that the endothelium is a drug with an ion youngdongbeop by a current applied to the electrode in a uniform close contact with the teeth and gums condition penetrate the treatment area.

Iontray, silicone rubber, polyester pading, shell, inner skin

Description

Iontophoretic drug delivery system

1 is a perspective schematic view showing an embodiment of a medical ion drug introduction device according to the present invention

Figure 2 is a schematic cross-sectional view of the ion tray is worn on the teeth and gums of the medical device for introducing an ion drug according to the present invention

Figure 3 is a schematic cross-sectional view showing another embodiment of the medical ion drug introduction device according to the present invention

             <Description of Symbols for Main Parts of Drawings>

1. Ion tray 2. Outer shell

3. Electrode 4. Endothelial

5a, 5b. Wire 6. Power Supply

7. Earthing electrode 8. Skin protection layer

The present invention relates to an ion drug delivery system for penetrating various chemicals into the mucosal tissues of teeth and gums by iontophoresis, and more particularly, a power supply device having a ground electrode, In the drug introduction device using the iontophoretic method consisting of an ion tray having an end portion formed in the "U" shape and the electrode is provided in close contact with the teeth and gums in the form of the site to be treated, the ion tray In order to maintain a close contact with the gums, a "U" shaped outer shell made of soft and elastic silicone rubber, a metal electrode located on the inner bottom surface of the outer shell, and placed inside the outer shell "U" padding made of synthetic cotton made of polyester material with high absorption and storage capacity It is composed of endothelial womb relates to a medical drug ion introduction unit, it characterized in that it is such that the endothelium is a drug with an ion youngdongbeop by a current applied to the electrode in a uniform close contact with the teeth and gums condition penetrate the treatment area.

In general, when a variety of drugs such as anesthesia solution is injected into the mucosal tissues such as gums, various drugs are injected using a syringe.However, in the case of using a syringe, the medicine solution penetrates from the point where the needle is inserted. Therefore, the infiltration state of the liquid drops so that it may be a part away from the injection site, and the chemical solution does not penetrate uniformly.In the case of a wide treatment area, it is cumbersome to inject several parts, and it is very difficult when there is fear in the syringe of a child patient. There were problems that need to be injected.

In order to solve the problem of using a conventional syringe, an iontophoresis method of introducing ions of soluble salts into the tissues of the body for therapeutic purposes has been introduced. When the drug forms anions using an electric current, the iontophoresis method is performed by a negative electrode. In the case of the formation of cations, the drugs were allowed to penetrate into the body tissues by the force of repulsion between the same charges by the anode.

As a conventional ion drug introduction apparatus using the iontophoretic method as described above, the Republic of Korea Patent Publication No. 10-0138382, "The non-conductive synthetic resin material is provided with an electrode support frame formed to be bent in the form of anesthesia and the electrode support An oral local anesthesia device by iontophoresis method in which an electrode made of gold foil or aluminum foil is embedded on the inner surface and a cotton wool filled with an anesthetic drug is absorbed in the inner space portion, and Korea Patent Publication No. 10-0411721 No. `` The tooth cover of the horseshoe shaped body in the form of a tooth, the aluminum (-) terminal installed in the applicator, a cotton soaked with fluorine compound, and a user's hand to be electrically energized to ionize the fluorine compound (+ A central control unit having a terminal and a circuit for controlling the devices, and the central control unit Tooth fluorine coating device consisting of a wire connecting the terminal and the aluminum terminal '', all of the pre-registered patents are cotton wool (general cotton) as a means for penetrating drugs such as anesthesia solution into the body tissues such as gums ( Cotton) and the cotton wool absorbed by the drug as described above (cotton) is accommodated in the electrode support frame or the applicator because the shape retaining force is greatly reduced in the function state and the water (absorption and storage capacity) of the drug falls When the close contact with the teeth and gums of the site to be treated, there was a problem that the drug is not effectively injected because it is not pressed evenly to the entire gum pressed by the teeth.

The present invention is to solve the problems described above to form a soft and elastic silicone rubber outer shell and to penetrate various kinds of drugs into body tissues such as gums of the polyester material with excellent absorption and storage capacity and shape retention of the drug By using synthetic cotton as the endothelium, it is harmless to the body and maintains high adhesiveness to body tissues with high bends such as gums even when a large amount of various drugs used for the treatment of teeth are absorbed. The cover of the surface of the endothelium is covered with a thin layer of skin protection layer, which greatly improves the feeling of wearing, so that the current flows stably from the ion tray to the gums and teeth without causing any damage to the skin of the gums during treatment. There is this.

In order to achieve this purpose, it is composed of a power supply device having a ground electrode, and an ion tray having an end portion formed in a “U” shape so as to be in intimate contact with teeth and gums in the form of a treated area. In the drug introduction device using the iontophoretic method, the ion tray is a "U" -shaped outer shell made of soft silicone rubber (silicone rubber) excellent in elasticity to maintain a close contact with the teeth and gums, Endothelial in the form of a "U" padding which is composed of a metal electrode positioned on the inner bottom surface and a synthetic cotton of polyester material which is located inside the outer shell and has high absorption and storage capacity and shape retention of the drug. The endothelium is evenly adhered to the teeth and gums, and the drug is removed by iontophoresis by the current applied to the electrode. There are features of the present invention that is to be penetrated into the region.

Hereinafter, the preferred configuration according to the present invention will be described in detail with reference to the drawings.

Medical ion drug introduction device according to the present invention is to infiltrate various chemical solutions into the mucosal tissue of the teeth and gums by iontophoresis, as shown in Figures 1 and 2 ion tray (weared on the teeth and 1) and a power supply device 6 having a ground electrode 7, wherein the ion tray 1 is soft and has excellent elasticity (silicone rubber) to maintain a close contact with the teeth and gums. The outer shell 2, the metal electrode 3 positioned below the inner surface of the outer shell 2, and the absorbent storage and shape-holding force of the drug stored in the outer shell 2 are high. It consists of an endothelial (4) made of a synthetic cotton of polyester material, the endothelial (4) is applied to the current applied to the electrode (3) from the power supply (6) in a state in which the endothelial (4) is evenly adhered to the teeth and gums By ion It is such that the drug is effectively penetrate into the treatment site to the Act.

The outer shell (2) is a portion constituting the framework of the ion tray (1), bent in the form of the teeth to be treated, the upper portion is formed in the form of the upper portion so that the teeth and gums are inserted into the inner side is formed in the "U" shape Although the overall material is made of excellent elasticity and non-conductive non-conductive silicon rubber, the ion tray (1) is kept evenly adhered to each other when it is inserted into severely curved teeth and gums. Drugs are designed to easily penetrate into tissues through teeth and gums.

In the present invention, the outer shell 2 is most preferably formed with a thickness of 1.0 ~ 2.0mm so as to be easy to wear on the teeth and gums while maintaining a constant elasticity.

The electrode 3 is fixedly attached to the inner bottom surface of the outer shell 2, and the power supply device 6 which is separately provided in the state in which the electric wire 5a is connected to the lower portion of the outer shell 2 and penetrates the outer shell 2 Is connected to the power supply device 6, and when the various drugs absorbed and stored in the endothelium 4 generate positive ions, the electrode 3 is made of silver (Ag). Consists of an anode of a material, on the contrary, when various drugs absorbed and stored in the endothelium 4 generate negative ions, the electrode 3 is a cathode made of a material such as silver chloride (AgCl). ) Electrode.

On the other hand, when fluorine (F) for tooth coating is used as the drug, the drug (KF, NF, etc.) is used, so that the fluorine acts as an anion, thereby forming the electrode (3) as a cathode, and penetrates the gum with the drug. When an anesthetic is used, a positively charged drug such as lidocaine is used, thereby forming the electrode 3 as an anode.

The power supply device 6 is connected to the electrode 3 of the ion tray 1 and the separate ground electrode 7 by wires 5a and 5b, respectively, to supply power to the electrode 3. By supplying by adjusting the current density or current capacity from the power supply 6, iontophoresis by the repulsive action between the ions and the electrode 3, skin cells of the teeth (fluorine coating, etc.) or gums (local anesthesia) Etc.) to infiltrate various drugs into body tissues.

The important parameters of various drug penetration in the iontophoresis method are current density and current dosage, which are controlled by the power supply device 6 to adjust the exact dosage into the body tissue. If the current density supplied from the supply device 6 is too large, the skin irritation may be severe, which may cause burns to the mucosal tissue. If the current density is adjusted to about 1.0 mA / cm 2 or less, if the current density is too weak, the penetration of the drug may be reduced. Since this takes a long time in the present invention, the current density is maintained at 0.2 ~ 0.6mA / ㎠, the current capacity is maintained at 2 ~ 4mA to perform the iontophoresis method for 1 to 10 minutes various drugs into the body tissue through the teeth and gums It is put in.

The ground electrode 7 is a pair formed with a pair of electrodes 3 of the ion tray 1 to form an electric circuit through the body, and the electrode 3 is an anode made of a material such as silver (Ag). If the electrode is composed of (anode), the ground electrode 7 is composed of a cathode (cathode), on the contrary, if the electrode (3) is composed of a cathode made of a material such as silver chloride (AgCl), the ground electrode (7) is an anode It consists of (anode) and is connected to the electric circuit through the body by bonding the ground electrode (7) to the hand or other body parts.

The endothelial (4) is located inside the outer shell (2) and is in contact with the teeth and gums, so that the various drugs absorbed and stored in the endothelial (4) is to be moved into the body tissue in accordance with the flow of current The shape of the cross section is “U” shaped so that the teeth and gums can be inserted into the open upper part so as to be in contact with each other. It is a synthetic cotton of polyester material with high absorption and storage capacity of the drug and high shape retention. As it is harmless to human body, a large amount of drug is absorbed and stored inside, and it shows high shape retention ability on severely curved teeth and gums, and keeps close contact with no spaced parts so that various drugs are easily introduced into the body tissue. It is supposed to be.

The endothelial (4) is formed of a thickness of 3 ~ 6mm and the synthetic cotton of the polyester material constituting the endothelial (4) is made of a polyester fiber having a thickness of 0.01 ~ 0.1mm in the shape of a cotton As shown in the experimental results of <Experimental Example>, it showed higher absorption storage capacity (function capability) and shape holding force than other materials.

<Experimental Example: Measurement of Absorption Storage (Function) and Shape Retention of Endothelial>

In the present invention, the polyester (cotton) synthetic cotton and cotton constituting the endothelium (cotton) and polyurethane foam (polyurethane foam) are formed in a cube shape of 1.5 cm wide, 1.5 cm long, 1.5 cm high, respectively Was produced.

Dropping water with the dropper to absorb and store the water in each specimen until the water does not flow to the outside was measured and repeated 7 times a total of 7 times the water content (ml) per each material was measured to determine the average water content In addition, the time for each specimen to be restored to its original state in the state of pressing the center portion with a force of 0.2kgf / ㎠ with a rod of 2mm diameter and pressing down the center portion with a force of 0.2kgf / ㎠ as shown above. The average shape holding force (return time: sec) was shown in <Table 1> by performing 5 replicates in total.

<Table 1> Average Absorption Storage (Function) and Shape Retention Results of Endothelial

 Average Absorption Storage Capacity (ml / g)  Average shape holding power (return time required: sec)  Comprehensive Evaluation  Polyester Synthetic Cotton  11.6  0.24 High average function, excellent shape retention in function, and non-toxic to human body  Cotton wool  9.6  62.4 Low average function and very low shape retention in function and non-toxic to human body  Polyurethane foam  17.7  2.7 Excellent average function, but low shape-maintenance and cytotoxicity

As in <Experimental Example>, the polyester synthetic cotton used as the endothelium (4) of the present invention has a high absorption storage capacity and excellent shape retention in a functioned state, so that it is in intimate contact with severely curved teeth and gums. Although it can penetrate the drug, cotton wool exhibits low absorption and storage ability, so it cannot penetrate a large amount of drug at once, and its shape holding power is so low that it cannot be intimately contacted with teeth and gums, and in the case of polyurethane foam It has excellent absorption and storage ability, so it can penetrate a large amount of drugs, but its shape retention ability is lower than that of polyester synthetic cotton, and it is especially harmful to the human body, so it cannot be used for human body.

Meanwhile, as another embodiment according to the present invention, the endothelial 4 made of the polyester synthetic cotton has a rough surface and a skin irritation due to the nature of the material, so that the skin may be damaged when directly contacted to the skin of the gum part. As shown in FIG. 3, the skin protective layer 8, which is 100% cotton-based cotton wool, is laminated in a thin layer on the surface portion of the endothelium 4, and is generally soft and free of skin irritation and stably flowing current. The cotton wool having the characteristics covers the entire surface of the endothelial 4, and the endothelial 4 made of polyester synthetic cotton gives skin irritation to the gum part to prevent skin damage and at the same time directly touches the teeth and gums. The skin protective layer (8) is to ensure a stable current flow to the teeth and gums.

The method of laminating the skin protective layer 8 on the surface of the endothelium 4 is to put the skin protective layer 8 made of thin cotton wool on the surface portion of the endothelium 4 and press it at a constant pressure into a cotton shape. The fibers are entangled with each other so that the skin protection layer 8 and the endothelium 4 can be attached to each other without the need for a separate adhesive or the like.

In addition, the skin protection layer 8 has a thickness of 0.5 to 1.5 mm so that the ion tray 1 is not too tightly fitted to the teeth and gums while the ion tray 1 is worn on the teeth and gums. It is most preferable that it is formed.

Hereinafter will be described the operation according to the present invention.

To absorb and store a certain amount of the drug to be put into the endothelial (4) of the present invention, the ion tray (1) is fitted to the teeth and gums of the site to be treated, wherein the outer shell (2) made of soft and elastic silicone rubber And it maintains a state in close contact with the gums and excellent shape retention even in a state where a large amount of drug is absorbed into the endothelial (4) made of polyester synthetic cotton is closely contacted with the teeth and gums without being spaced apart.

The ground electrode 7 connected to the wire 5b of the power supply device 6 while the ion tray 1 connected to the wire 5a of the power supply device 6 is connected to the teeth and gums of the region to be treated as described above. ) Is grounded to another body part, and the current density is maintained at 0.2 to 0.6 mA / cm 2 from the power supply device 6 and the current capacity is maintained at 2 to 4 mA, followed by iontophoresis for 1 to 10 minutes. Absorbed and stored in the) is penetrated into the tissue through the tissue of the teeth or gums.

According to the present invention as described above by forming a skin with a soft and elastic silicone rubber and by using a synthetic cotton of polyester material having excellent absorption and storage capacity and shape retention of the drug as a means for penetrating various drugs into body tissues such as gums It is harmless to the body, and even when a large amount of various drugs used for teeth or gums are absorbed, it maintains high adhesion to body tissues with high flexion, such as gums, so that the drug can be effectively and evenly applied to the area to be treated. When the skin protection layer of the material is thinly covered, the wearing feeling is greatly improved, and the current flows stably from the ion tray to the gums and teeth without causing a wound on the skin of the gum part during treatment.

Claims (6)

Using the iontophoresis method which consists of a power supply equipped with a grounding electrode and an ion tray which is bent in the shape of the teeth to be treated and its longitudinal section is formed in a “U” shape so that teeth and gums can be inserted and an electrode is provided therein. In the drug introduction device, the ion tray (1) is made of silicone rubber in order to maintain a state in close contact with the teeth and gums and the longitudinal section of the "U" shaped outer shell (2), and the outer shell of the It is composed of a metal electrode 3 located on the inner bottom surface and a synthetic cotton of polyester material having a high absorption and storage capacity and shape retention strength of the drug to be stored and stored inside the shell 2, and its longitudinal section is " U " It consists of an endothelial (4) shaped like a child and iontophoretic method is applied by the current applied from the power supply device (6) to the electrode (3) while the endothelial (4) is evenly in contact with the teeth and gums. Is such that the drug is to penetrate the treatment area medical drug ion introduction unit, characterized in that a. Using the iontophoresis method which consists of a power supply equipped with a grounding electrode and an ion tray which is bent in the shape of the teeth to be treated and its longitudinal section is formed in a “U” shape so that teeth and gums can be inserted and an electrode is provided therein. In the drug introduction device, the ion tray (1) is made of silicone rubber in order to maintain a state in close contact with the teeth and gums and the longitudinal section of the "U" shaped outer shell (2), and the outer shell of the It is composed of a metal electrode 3 located on the inner bottom surface and a synthetic cotton of polyester material having a high absorption and storage capacity and shape retention strength of the drug to be stored and stored inside the shell 2, and its longitudinal section is " U " It consists of an endothelial 4 in shape and a thin layer of skin protection layer 8 which covers the entire surface of the endothelial 4 to reduce skin irritation of the gum part. Medical ion drug, characterized in that the drug penetrates into the treatment site by iontophoresis by the current applied to the electrode 3 from the power supply device 6 in a state where the endothelial 4 is evenly attached to the teeth and gums. Introduction device. The method according to claim 1 or 2, wherein the endothelial (4) is formed of a thickness of 3 ~ 6mm and the thickness of the synthetic fibers constituting the endothelial is characterized in that the synthetic cotton of polyester material is 0.01 ~ 0.1mm Medical ion drug introduction device to. According to claim 1 or 2, wherein the shell (2) is a medical ion drug introduction device, characterized in that the thickness is formed to 1.0 ~ 2.0mm to be easy to wear on the teeth and gums while maintaining a constant elasticity. The power supply device according to claim 1 or 2, wherein the electrode 3 is connected to the power supply device 6 in a state in which a wire 5a is connected to a lower portion of the center part and penetrates the outer shell 2. (6) is supplied with power, wherein the power supply device (6) is a medical ion, characterized in that it is provided with a ground electrode (7) connected by a separate wire (5b) to attach to other parts of the human body Drug introduction device. The device of claim 2, wherein the skin protective layer (8) has a thickness of 0.5 to 1.5 mm so as to be easily worn on teeth and gums.

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