KR100647720B1 - Foodstuff for Recovering Hangover - Google Patents

Abstract

The present invention relates to a food exhibiting a hangover effect comprising the composition of the Tortoiseshell and vitamin C. Foods exhibiting a hangover-relieving effect of the present invention includes a composition of dried tortoiseshell and vitamin C in a ratio of 4: 1 to 8: 1 (w / w). Foods exhibiting a hangover-relieving effect of the present invention can rapidly reduce the concentration of alcohol and blood acetaldehyde in the blood after ingestion of alcohol, so that it can be widely used to resolve the hangover symptoms caused by excessive alcohol intake.

Tortoiseshell, Vitamin C, Foods That Relieve Hangover

Description

Food for Recovering Hangover

The present invention relates to a food exhibiting a hangover relief effect. More specifically, the present invention relates to a food exhibiting a hangover effect comprising the composition of Tortoiseshell and Vitamin C.

In terms of nutrition, alcohol has the advantage of providing relatively high calories, helping blood circulation and digestion, and increasing blood HDL-cholesterol to prevent cardiovascular diseases. Alcoholism, which is caused by some people who consume excessive alcohol, has become a social problem because it can cause deficiency and malnutrition, impair liver function, and even damage brain tissue.

When alcohol is consumed excessively, the inevitable hangover symptoms are caused by alcohol being broken down in the body and converted into substances that are harmful to the body, and are mainly caused by headaches and heartburn. In order to solve this problem, substances that can accelerate the decomposition of alcohol in the body or remove harmful substances caused by the metabolism of alcohol have been studied.

For example, Korean Patent Application No. 2003-94740 discloses a method for preparing a hangover-removing beverage containing a large amount of oxygen, and Korean Patent Application No. 2002-23167 discloses a drink composition for relieving hangover using vegetables. In addition, Korean Patent Application No. 2002-2470 discloses a hangover composition containing decosinol as an active ingredient, and Korean Patent Application No. 2002-18117 discloses a method for producing an anti-hangover drink based on silk fibroin. Korean Patent Application No. 2002-14250 discloses a method for the preparation of anti-drunken beverages using extracts of Maengsui, and Korean Patent Application No. 2002-9851 discloses a functional drink for removing the hangover using a strip and a method for producing the same. Korean Patent Application No. 2002-9291 discloses a method for hangover relief and antioxidant activity containing sewage extract. Water is disclosed, and Korean Patent No. 403721 discloses a low alcohol insoluble extract fraction and a polysaccharide material having a hepatotoxicity and hangover activity isolated from a locust tree and a composition containing the same, and Korean Patent Application No. 2001-80108 Discloses a hangover using alder. However, since the hangover releaser has a slight degree of promoting alcohol decomposition, and did not show an effective hangover elimination effect, efforts to replace the conventional hangover remover have been continued.

Therefore, the present inventors have made a thorough research to develop a hangover releasing agent that can exhibit a more effective hangover, as a result of ingesting food containing the composition of the dried spine (stalk) and vitamin C, blood alcohol concentration And it was confirmed that the blood acetaldehyde concentration can be reduced quickly, the present invention was completed.

After all, the main object of the present invention is to provide a food exhibiting a hangover effect comprising a composition of dried tortoiseshell and vitamin C.

Foods exhibiting a hangover relief effect of the present invention include a composition of a dried Tortoiseshell and vitamin C in a ratio of 4: 1 to 8: 1 (w / w): The dried tortoise is not particularly limited thereto, but is preferably used in the form of tortoise powder, and more preferably, dried powder of the tortoise which has been steamed and dried in the shade and powdered; Alternatively, the star persimmon is hydrothermally treated, dried, calcined and powdered at a high temperature, and used in the form of a small ingredient powder, most preferably a small ingredient powder.

The inventors of the present invention to examine the hangover effect of various components including aspartic acid, vitamin C, taurine, etc., which are known to be effective in hangover, in order to develop a hangover killer that can exhibit hangover effect more effectively. Attention was drawn to the tortoiseshell, the spine of Zara.

The turtle is a reptile belonging to the turtle neck, Jaraaceae, and has been used as a tonic and aphrodisiac since ancient times, and in particular, oriental medicine has used tortoise, the spine of the turtle, as a valuable herbal medicine. For example, agree that "the tortoises control organ abnormalities, protect the body and blood, and reinforce physiological functions and strength." It is described. However, tortoiseshell contains abundant protein and fat and is easily deteriorated at room temperature. However, in one case, the tortoiseshell is treated with steam, and then dried in the shade to be preserved. In order to improve the preservation by processing a short shell for a short time. For example, Korean Patent Registration No. 302054 discloses a processing method of a tortoiseshell, comprising the steps of hot water treatment and drying of the tortoiseshell, followed by baking at a high temperature in a kiln, and powdering.

The present inventors found that Tortoiseshell can rapidly lower blood alcohol and blood acetaldehyde concentrations, as compared to conventional aspartic acid, vitamin C and taurine, which are known to have excellent hangover effects. It was confirmed that the tortoiseshell can lower blood alcohol and blood acetaldehyde levels faster than extract.

On the other hand, in order to maximize the hangover removal effect of the above-mentioned Tortoiseshell, it is confirmed whether or not to increase the hangover effect by mixing the Tortoiseshell and various components exhibiting a hangover elimination effect, aspartic acid, taurine, etc. Although it did not have a significant effect on the hangover effect, it was confirmed that vitamin C could increase the hangover elimination effect, and the ratio of starch and vitamin C was 4: 1 to 8: 1 (w / w). I could see the goodness.

On the other hand, the composition of the tortoiseshell and vitamin C can be prepared in the form of food exhibiting a hangover relief effect with various food additives. That is, tortoiseshell and vitamin C include sugars (e.g., monosaccharides, disaccharides, polysaccharides, sugar alcohols, etc.), flavoring agents (e.g., taumartin, stevia extract, saccharin, aspartame, etc.), nutrients, vitamins, edible electrolytes, flavoring agents, Forms of foods that have a hangover effect with food additives such as colorants, neutralizers (e.g. cheese, chocolate, etc.), alginic acid, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonating agents It can be prepared as. At this time, the form of the food is not particularly limited thereto, but may be prepared by adding a variety of foods, including wire, noodles, confectionery, beverages, meat, fish, herbs, steamed rice or rice, etc. Addition amount of the composition of the Tortoiseshell and vitamin C added to the food exhibiting is not particularly limited.

Foods exhibiting a hangover-relieving effect of the present invention can rapidly reduce the concentration of alcohol and blood acetaldehyde in the blood after ingestion of alcohol, so that it can be widely used to resolve the hangover symptoms caused by excessive alcohol intake.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it will be apparent to those of ordinary skill in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. .

Example 1 Search for Ingredients Showing Hangover Relief Effect

Green tea extract, aspartic acid, taurine, vitamin C, and tortoise powder were searched for the components showing the effect of lowering blood alcohol concentration and blood acetaldehyde concentration.

Example 1-1 : Search for ingredients showing a blood alcohol concentration lowering effect

After 60 minutes of oral administration of 38% (v / v) ethanol solution in 5 to 300 g of rats weighing 300-350 g, 10 rats were given nothing (control) or green tea extract, aspartic acid, taurine, Vitamin C and Tortoiseshell powder were orally administered to 10 rats at an amount of 10 mg / kg body weight (Experimental Group 1 to 5), and after 0, 1, 2, 3, 6 and 8 hours, blood was collected in each experimental group. 0.2 ml was collected. At this time, the green tea extract was obtained by extracting green tea with 70% (v / v) ethanol solution, and then dried, and the powdered green tea powder was obtained by treating the green tea with steam, then drying and powdering.

The blood collected was reacted with trichloroacetic acid for 5 minutes and then centrifuged at 2,000 rpm for 5 minutes to obtain plasma. Subsequently, 0.1 mL of each obtained plasma was mixed with 2.9 mL of NAD-ADH solution included in an alcohol concentration measurement kit (# 332, Sigma Chem. Co., USA), reacted at 37 ° C. for 10 minutes, and then at 340 nm. Absorbance was measured and blood alcohol concentration was calculated by substituting the measured values into the standard curve (see Table 1).

When the hangover constituents were administered to ethanol-administered mice, the change in blood alcohol concentration according to each hangover cure component (unit: mg / dl) Elapsed time (hours) Control Experimental group 1 Experiment group 2 Experiment group 3 Experimental Group 4 Experimental group 5 0 84.2 ± 7.1 84.2 ± 7.1 84.2 ± 7.1 84.2 ± 7.1 84.2 ± 7.1 84.2 ± 7.1 One 77.3 ± 9.5 61.0 ± 2.6 58.0 ± 9.8 62.3 ± 8.5 81.0 ± 9.0 48.3 ± 6.4 2 61.8 ± 5.8 38.3 ± 0.8 36.1 ± 7.7 42.8 ± 5.4 59.0 ± 2.4 25.6 ± 4.5 3 54.0 ± 3.8 19.3 ± 5.7 16.5 ± 1.7 23.6 ± 2.3 33.5 ± 3.8 12.4 ± 2.1 6 18.0 ± 2.1 7.6 ± 1.7 3.2 ± 0.8 9.8 ± 1.2 14.2 ± 1.8 0 8 0 0 0 0 0 0

As shown in Table 1, all the experimental groups administered green tea extract (experimental group 1), aspartic acid (experimental group 2), taurine (experimental group 3), vitamin C (experimental group 4) and tortoise powder (experimental group 5) were superior to the control group. It was found that the alcohol removal effect was shown, and among the experimental groups, Tortoisepa powder showed the best blood alcohol removal effect.

Example 1-2 : Search for ingredients showing the effect of lowering acetaldehyde concentration in blood

After 60 minutes of oral administration of 38% (v / v) ethanol solution in 5 to 300 g of rats weighing 300-350 g, 10 rats were given nothing (control) or green tea extract, aspartic acid, taurine, Vitamin C and Tortoiseshell powder were orally administered to 10 rats at an amount of 10 mg / kg body weight (Experimental Group 1 to 5), and after 0, 1, 2, 3, 6 and 8 hours, blood was collected in each experimental group. 0.2 ml was collected. At this time, the green tea extract and tortoise powder used the same as in the previous Example 1-1.

The blood collected was reacted with trichloroacetic acid for 5 minutes and then centrifuged at 2,000 rpm for 5 minutes to obtain plasma. 0.1 ml of each obtained plasma was then subjected to a gas chromatography system (Vista 6000, Varian Co., USA; HayeSepp 80 / 100mesh; 2m x 1/8 "; oven temperature 80 to 149 ° C; injection temperature 150 ° C; detection temperature 250 Acetaldehyde peaks were detected by applying to a mobile phase: helium, and the area of the detected peaks was measured to calculate the concentration of acetaldehyde (see Table 2).

Changes in Acetaldehyde Concentration in Blood According to the Types of Hangover Relief Components in Ethanol-treated Mice Elapsed time (hours) Control Experimental group 1 Experiment group 2 Experiment group 3 Experimental Group 4 Experimental group 5 0 17.1 ± 1.9 17.1 ± 1.9 17.1 ± 1.9 17.1 ± 1.9 17.1 ± 1.9 17.1 ± 1.9 One 23.3 ± 2.9 27.9 ± 5.5 26.9 ± 6.9 24.0 ± 2.2 23.7 ± 4.0 20.3 ± 3.2 2 36.7 ± 4.2 38.6 ± 7.1 33.3 ± 8.9 29.6 ± 7.3 46.9 ± 6.9 34.2 ± 9.2 3 80.4 ± 8.4 61.5 ± 8.4 50.5 ± 9.9 40.2 ± 9.3 67.6 ± 9.9 38.3 ± 3.1 6 33.1 ± 6.9 35.4 ± 3.7 17.5 ± 5.0 17.0 ± 6.8 17.5 ± 3.4 25.0 ± 7.3 8 5.7 ± 1.2 4.7 ± 1.3 3.5 ± 1.1 4.8 ± 1.8 5.1 ± 1.5 3.4 ± 1.4

As shown in Table 2, all the experimental groups administered green tea extract (experimental group 1), aspartic acid (experimental group 2), taurine (experimental group 3), vitamin C (experimental group 4) and tortoise powder (experimental group 5) were superior to the control group. It was found that the acetaldehyde removal effect was shown, and among the experimental groups, Tortoiseph powder showed the best acetaldehyde removal effect in blood.

Example 1-3 : Searching for Ingredients That Can Assist Hangover Relief Effect of Starpuff Powder

In Examples 1-1 and 1-2, it was confirmed that the starch powder effectively removes the blood alcohol and acetaldehyde concentration, and thus the hangover removal effect is the best. I wanted to search.

That is, 60 ml of 38% (v / v) ethanol solution orally administered to 300-350 g rats, and then 60 rats were administered nothing (negative control), or 10 rats 10mg of persimmon powder per kg of body weight (positive control) or 10 mg of green tea extract per kg of body weight + 10mg of persimmon powder, 10mg of asparagus acid + 10mg of persimmon powder, 10mg of taurine + 10mg of persimmon powder and 10mg of vitamin C. After the administration of 10 mg of powder powder to oral administration (experimental groups 11 to 14), after 0, 1, 2, 3, 6 and 8 hours, 0.2 ml of blood was collected from each experimental group. At this time, the green tea extract and tortoise powder used the same as in the previous Example 1-1.

Then, the blood alcohol concentration and the blood acetaldehyde concentration were calculated and compared using the methods of Examples 1-1 and 1-2 above (see Tables 3a and 3b).

Changes in Blood Alcohol Concentrations According to Kinds of Hangover Powders and Their Hangover Components in Ethanol-treated Mice Elapsed time (hours) Negative control Positive control Experimental Group 11 Experimental Group 12 Experimental Group 13 Experimental group 14 0 84.2 ± 7.1 84.2 ± 7.1 84.2 ± 7.1 84.2 ± 7.1 84.2 ± 7.1 84.2 ± 7.1 One 77.3 ± 9.5 48.3 ± 6.4 45.2 ± 3.6 46.8 ± 7.8 42.2 ± 8.5 40.1 ± 3.0 2 61.8 ± 5.8 25.6 ± 4.5 22.3 ± 2.8 24.6 ± 3.7 20.4 ± 3.4 18.0 ± 1.4 3 54.0 ± 3.8 12.4 ± 2.1 10.3 ± 1.7 10.7 ± 2.7 10.1 ± 1.3 7.5 ± 0.8 6 18.0 ± 2.1 0 0 0 0 0 8 0 0 0 0 0 0

As shown in Table 3a, compared to the positive control group administered only the Tortoiseshell powder, all experimental groups in which the Tortoiseph powder and green tea extract (Experimental Group 11), aspartic acid (Experimental Group 12) and taurine (Experimental Group 13) were mixed and similar to the positive control group Although the blood alcohol removal effect was shown, the experimental group administered with a mixture of tortoise powder and vitamin C (experimental group 14) showed better blood alcohol removal effect than the positive control group.

Changes in Acetaldehyde Concentration in Blood according to the Types of Starch Powder and Each Hangover Relief Component in Ethanol-treated Mice Elapsed time (hours) Negative control Positive control Experimental Group 11 Experimental Group 12 Experimental Group 13 Experimental group 14 0 17.1 ± 1.9 17.1 ± 1.9 17.1 ± 1.9 17.1 ± 1.9 17.1 ± 1.9 17.1 ± 1.9 One 23.3 ± 2.9 20.3 ± 3.2 19.5 ± 3.9 19.8 ± 3.2 20.1 ± 3.0 17.6 ± 3.2 2 36.7 ± 4.2 34.2 ± 9.2 33.8 ± 3.9 33.4 ± 3.3 33.2 ± 3.9 22.4 ± 3.2 3 80.4 ± 8.4 38.3 ± 3.1 36.9 ± 2.9 37.1 ± 2.3 36.5 ± 2.9 26.4 ± 2.1 6 33.1 ± 6.9 25.0 ± 7.3 23.4 ± 2.0 24.7 ± 2.8 22.1 ± 2.4 15.3 ± 2.3 8 5.7 ± 1.2 3.4 ± 1.4 3.3 ± 0.1 3.1 ± 0.8 3.3 ± 0.5 2.0 ± 0.4

As shown in Table 3a, compared to the positive control group administered only the Tortoiseshell powder, all experimental groups in which the Tortoiseph powder and green tea extract (Experimental Group 11), aspartic acid (Experimental Group 12) and taurine (Experimental Group 13) were mixed and similar to the positive control group Although it showed the effect of removing acetaldehyde in blood, it was confirmed that the experimental group administered by mixing Tortoise powder and vitamin C (Experimental group 14) showed better removal of acetaldehyde in blood than the positive control group.

Therefore, it was confirmed that more effective hangover can be resolved when a combination of Starpuff powder and vitamin C is administered.

Example 2 Determination of Optimal Composition Ratio of Tortoiseshell and Vitamin C with Hangover Relief Effect

As shown in the results of Examples 1-3, since the composition containing the starch powder and vitamin C may exhibit a hangover relief effect, the composition ratio of starch powder and vitamin C, which exhibits the best hangover resolution, was determined.

That is, 60 ml of 38% (v / v) ethanol solution orally administered to 300-350 g rats, and then 60 rats were not administered to 10 rats (control) or 10 rats each. 10mg (experimental group 21) and 10mg of mixed cactus powder and vitamin C 1: 1 (w / w) per kilogram of body weight powder and vitamin C 0: 1 (w / w) ), 10 mg of the composition of the tortoise powder and vitamin C 2: 1 (w / w) (experimental group 23), 10 mg of the composition of the tortoise powder and vitamin C 3: 3 (w / w) (experimental group 24), Tortoise powder and Vitamin C in a composition of 10 mg (experimental group 25) mixed with 4: 1 (w / w), Tortoise powder and Vitamin C in a composition of 10 mg (test group 26) mixed in 5: 1 (w / w) 10 mg of composition containing vitamin C and 6: 1 (w / w) (experimental group 27), 10 mg of composition containing tortoise powder and vitamin C 7: 7 (w / w), tortoise powder and vitamin 10 mg of composition (Exp. 29) mixed with C at 8: 1 (w / w) Oral administration of 10 mg of the composition of horses and vitamin C mixed at 9: 1 (w / w) and 10 mg of the tortoise powder (experimental group 30) and 10 mg of the composition of vitamin C mixed at 10: 1 (w / w) (experimental group 31) After 3 hours, 0.2 ml of blood was collected from each experimental group. At this time, the green tea extract and tortoise powder used the same as in the previous Example 1-1.

Then, using the method of Examples 1-1 and 1-2, the blood alcohol concentration and the blood acetaldehyde concentration were calculated and compared (see Tables 4a and 4b).

Changes in Serum Alcohol Concentration According to the Compositional Ratio of Tortoiseshell Powder and Vitamin C in Ethanol-treated Mice (Unit: mg / dl) Experimental group Tortoiseshell powder: Vitamin C (w / w) Blood alcohol level Control 0: 0 54.0 ± 3.8 Experimental group 21 0: 1 33.5 ± 3.8 Experimental Group 22 1: 1 15.8 ± 0.4 Experimental Group 23 2: 1 14.1 ± Experimental Group 24 3: 1 13.5 ± Experimental Group 25 4: 1 10.4 ± Experimental Group 26 5: 1 8.2 ± Experimental Group 27 6: 1 5.1 ± Experimental group 28 7: 1 7.8 ± Experimental Group 29 8: 1 9.4 ± Experimental group 30 9: 1 12.7 ± Experimental group 31 10: 1 13.8 ± 1.5

As shown in Table 4a, although the composition ratio of tortoise powder and vitamin C is 1: 1 to 6: 1 (w / w), the alcohol concentration of blood decreases as the ratio of tortoise powder increases, but tortoise powder and vitamin C After the composition ratio of 7: 1 (w / w) showed a tendency to increase the blood alcohol concentration again. In particular, when the composition ratio of tortoise powder and vitamin C is 4: 1 to 8: 1 (w / w), it was found that blood alcohol concentration was significantly decreased.

Changes in Acetaldehyde Concentration in Blood according to the Composition Ratio of Tortoiseshell Powder and Vitamin C in Ethanol Administered Mice Experimental group Tortoiseshell powder: Vitamin C (w / w) Acetaldehyde concentration in blood Control 0: 0 80.4 ± 8.4 Experimental group 21 0: 1 67.6 ± 9.9 Experimental Group 22 1: 1 48.3 ± 2.1 Experimental Group 23 2: 1 46.4 ± 1.8 Experimental Group 24 3: 1 44.2 ± 1.6 Experimental Group 25 4: 1 36.9 ± 0.9 Experimental Group 26 5: 1 30.4 ± 1.1 Experimental Group 27 6: 1 25.3 ± 0.5 Experimental group 28 7: 1 26.4 ± 1.4 Experimental Group 29 8: 1 29.8 ± 1.8 Experimental group 30 9: 1 34.8 ± 1.9 Experimental group 31 10: 1 42.4 ± 2.5

As shown in Table 4b, although the composition ratio of tortoise powder and vitamin C is 1: 1 to 6: 1 (w / w), the concentration of acetaldehyde in blood decreases as the ratio of tortoise powder increases, but tortoise powder and vitamin After the composition ratio of C 7: 1 (w / w), the concentration of acetaldehyde in blood was increased again. In particular, when the composition ratio of tortoise powder and vitamin C is 4: 1 to 9: 1 (w / w), the concentration of acetaldehyde in blood was significantly decreased.

Therefore, when the results were summarized, it was confirmed that when the composition of the Tortoiseph powder and vitamin C was mixed at 4: 1 to 8: 1 (w / w), it showed an excellent hangover relief effect.

Example 3 : Preparation of food exhibiting hangover effect comprising the composition of Tortoiseshell powder and vitamin C

As determined in Example 2, the tortoise powder and vitamin C were mixed with 4: 1 to 8: 1 (w / w) to prepare a food exhibiting the following hangover effect.

Example 3-1 Preparation of Noodles with Hangover Relief Effect

Mixing 20 g of the powdered tortoise powder with vitamin C at 6: 1 (w / w), 700 mg of wheat flour, 80 g of eggs, and 200 g of water to prepare a dough. Noodles having an effect were prepared.

Example 3-2 Preparation of Biscuits Having a Hangover Relief Effect

Biscuit is prepared by mixing 20 g of the powdered tortoise powder and vitamin C at 6: 1 (w / w), 700 mg of wheat flour, 200 g of milk, and 80 g of eggs. Was prepared.

Example 3-3 Preparation of Drinks Having a Hangover Relief Effect

20 g of the tortoise powder and vitamin C were mixed at 6: 1 (w / w), 10 mg of fruit flavor, 100 g of fruit juice, 10 mg of sodium benzoate, and 900 ml of water were mixed to prepare a beverage having a hangover effect.

Example 3-4 Preparation of Soybean Sprouts No. 1 showing Hangover Relief Effect

20 g of a tortoise powder and vitamin C mixed at 6: 1 (w / w), 150 g of red pepper powder, a small amount of salt, garlic, pepper, onion and ginger were mixed to prepare a seasoning for bean sprouts, 200 g of seasoning and 500 g of bean sprouts were mixed, cooked by a conventional method, and soybean sprouts to which a hangover suppressing effect was prepared.

Example 3-5 Preparation of Soybean Paste Soybean Curd

Mix 20 g of powdered tortoise powder with vitamin C at 6: 1 (w / w), 600 g of soybean paste, a small amount of salt, garlic, pepper, onion, and ginger, put it in 500 ml of water, and cook in a conventional manner. Doenjang crab was prepared to exhibit a hangover effect.

Example 3-6 Preparation of Multigrain Rice with Hangover Relief Effect

20g, 50g of black soybean, 50g of millet, 50g of millet rice and 300g of white rice were mixed with starch powder and vitamin C at 6: 1 (w / w), and cooked in a conventional manner to prepare grain rice having a hangover effect. It was.

As described and demonstrated in detail above, the present invention provides a food exhibiting a hangover effect comprising the composition of the Tortoiseshell and vitamin C. Foods exhibiting a hangover-relieving effect of the present invention can rapidly reduce the concentration of alcohol and blood acetaldehyde in the blood after ingestion of alcohol, so that it can be widely used to resolve the hangover symptoms caused by excessive alcohol intake.

Claims (2)

A hangover relief food comprising a composition of dried tortoiseshell and vitamin C in a ratio of 4: 1 to 8: 1 (w / w). The method of claim 1, The dried tortoise is characterized in that it is a small powder of the tortoise after steaming the tortoise and drying it in the shade and then drying the powdered tortoise or the hot powder of the tortoise, followed by drying and firing and powdering at high temperature. Hangover food.