KR100603429B1 - Composition for alleviation of pain of work-related musculoskeletal disorders and socks made therefrom - Google Patents

Abstract

The present invention consists of 5 to 15% by weight of anionic powder, 4 to 8% by weight of capsaicin, 3 to 20% by weight of urethane binder and 10 to 20% by weight of acrylic binder, and further contain 0.5 to 5 ppm of platinum. It relates to a composition for relieving analgesic of musculoskeletal disorders and functional socks prepared using the same.

The composition for analgesic relief of musculoskeletal disorders of the present invention contains capsaicin, which has been proven to have an analgesic effect in musculoskeletal disorders, and is composed of an appropriate amount and composition for minimizing rejection when applying capsaicin. Functional socks can be manufactured by printing the bottom surface of the socks in contact.

Capsaicin, Socks, Anion Powder, Musculoskeletal Diseases

Description

COMPOSITION FOR ALLEVIATION OF PAIN OF WORK-RELATED MUSCULOSKELETAL DISORDERS AND SOCKS MADE THEREFROM}             

1 is a photograph observing the surface of the bottom surface of the socks prepared according to the manufacturing method of the present invention by a scanning electron microscope,

Figure 2 is a photograph of the surface of the socks bottom prepared according to the manufacturing method of the present invention observed by scanning electron microscope according to the number of washing.

The present invention relates to a composition for analgesic relief of musculoskeletal disorders and a functional sock prepared using the same. More specifically, the composition of the present invention contains capsaicin, which has been proven to have an analgesic effect in musculoskeletal disorders, and upon application of capsaicin. It consists of a suitable amount and composition for minimizing the rejection, and relates to a variety of uses of the composition applied to the fiber material.

Capsaicin is a spicy ingredient contained in the juice of capsicum frutescens or capsicum annum , and it is widely known that it has an analgesic-relieving effect (US Pat. No. 4,313,958). In the late 1940's, capsaicin was initially shown to be a strong stimulus, but over time, analgesic action was discovered. Thus, research has been actively conducted to synthesize capsaicin derivatives and develop new analgesics using the same. The analgesic action of capsaicin has been found to exert its effect by releasing and depleting the 'P substance', which is known as a pain transporter, in the nerve endings of the body.

However, in the application of capsaicin, as the toxicity of capsaicin itself is too strong to apply it directly to the clinical, research to supplement it is active in recent years. For example, Korean Patent Registration Publication Nos. 1992-9574 and Patent No. 0315184 have developed novel capsaicin derivatives that can provide an increased analgesic effect while minimizing the side effects noted above, and the derivatives and nonsteroidal analgesics. Pharmaceutical compositions based on the above have been known.

In addition, capsaicin has a high caloric and heat-generating intrinsic property, which can impart hotness to the skin with only a small amount of medicine. Therefore, even in musculoskeletal disorders such as arthritis, muscle strain, sprain, tendonitis and bursitis, It is known to have an excellent analgesic effect.

Work-related Musculoskeletal Disorders (also referred to as occupational musculoskeletal disorders) are also referred to as work-related musculoskeletal disorders. , A chronic health disorder that complains of pain and paresthesia by damaging body parts when fatigue accumulates in the musculoskeletal system due to a combination of inadequate working environment (temperature, humidity, noise, lighting, etc.), insufficient manpower, and tight delivery date. to be. Recently, the number of patients diagnosed with industrial accidents is rapidly increasing due to widespread awareness of musculoskeletal disorders such as severe pain and numbness in the neck and shoulders or low back pain at work.

These types of musculoskeletal disorders include Ankylosing spondylitis, Tendonitis, Adhesive capsulitis, Febrile convulsion, Osteoarthritis, Osteoporosis, Osteoporosis ), Arthritis (Infectious arthritis), Arthritis (Rheumatoid) (Rheumatic arthritis), Arthritis (rheumatic, pediatric) (Juvenile rheumatoid arthritis), Tension or vascular headache, Disk (Herniated disk), Lyme arthritis ( Lyme disease, Rheumatic fever, Peripheral neuropathy, Trigeminal neuralgis, Carpal-tunnel syndrome, Bursitis, Gout, Migraine headache, etc. The range is broad. However, there is still insufficient development of application fields for the treatment of musculoskeletal disorders using capsaicin.

Accordingly, the present inventors have tried to apply capsaicin, which is high in calories and has high exothermicity, which can impart hotness of the skin even with a small amount of medicine, to a fiber in direct contact with the body. Intended for application. In other words, the socks are wearing shoes such as sneakers or shoes in the state of wearing socks, the air flow is not smooth, the sweat caused by more than anywhere else, such as odor and athlete's foot caused by bacteria. Therefore, in recent years, in order to prevent such odors and athlete's foot, reinforcing antibacterial and anti-odor ingredients have been developed, but in recent years as the interest in the foot is increased, the wearer's health is also considered through the socks, the breathability of the socks It is pursuing the functionality that can improve foot health by wearing socks or improving the material.

Therefore, by providing a functional socks that can provide an analgesic effect of musculoskeletal disorders using a composition containing capsaicin, while being applied to the socks worn on the foot farthest from the body, when wearing caused by the strong smell of the capsaicin drugs The present invention was completed by confirming that rejection can be eliminated.

It is an object of the present invention to provide a composition for analgesic relief of musculoskeletal disorders containing capsaicin.

Another object of the present invention is to provide a functional socks prepared using the composition for analgesic relief of musculoskeletal disorders containing capsaicin.

Still another object of the present invention is to provide a method of manufacturing the functional socks.

The present invention provides 5 to 15% by weight of anion powder, 4 to 8% by weight of the capsaicin drug, 3 to 20% by weight of the urethane binder and 10 to 20% by weight of the acrylic binder provides a composition for analgesic relief of musculoskeletal disorders. More specifically, 5 to 15% by weight of anionic powder, 4 to 8% by weight of capsaicin, 3 to 20% by weight of a urethane binder and 10 to 20% by weight of an acrylic binder, and 1 to 3% by weight of a fragrance which is a common additive, Musculoskeletal system consisting of minor components consisting of 1 to 4% by weight of castor oil, 1 to 2% by weight of emulsifier, 1 to 2% by weight of penetrant, and 1% by weight of thickener, and mixed with the remaining amount of water excluding the main component and the composition Provided are compositions for relieving analgesia.

The composition may further contain 0.5 to 5 ppm of platinum. In addition, the composition has a viscosity of 30,000 to 400,000 cps.

The capsaicin medicament contains 1,500,000 to 3,000,000 IU capsaicin, wherein the capsaicin medicament is selected from sustained or capsule forms impregnated with silica; Or mixed forms thereof.

The anion powder uses at least one selected from the group consisting of selenium, silicon, zinc, silver, iron, phosphorus and sulfur.

The present invention provides a functional sock produced by printing the bottom surface of the sock in contact with the skin using the composition for pain relief of the musculoskeletal disorders.

The present invention comprises the steps of preparing a composition of the present invention having a viscosity of 30,000 to 40,000 cps; Preparing a sock woven from any one fiber selected from the group consisting of polytrimethylene terephthalate (PTT) fibers, cotton fibers, mixed fibers of cotton and polyester, nylon fibers and nylon yarn processed fibers; Coating the prepared composition on the inner bottom surface of the sock; Drying at 130 to 140 ° C. for 30 seconds; And it provides a method for producing a functional socks consisting of heat setting for 30 seconds at 170 ℃ to 175 ℃.

Hereinafter, the present invention will be described in detail.

The present invention provides 5 to 15% by weight of anion powder, 4 to 8% by weight of the capsaicin drug, 3 to 20% by weight of the urethane binder and 10 to 20% by weight of the acrylic binder provides a composition for analgesic relief of musculoskeletal disorders.
More specifically, the composition for analgesic relief of musculoskeletal disorders of the present invention is composed of 5 to 15% by weight of anionic powder, 4 to 8% by weight of capsaicin, 3 to 20% by weight of urethane-based binder, and 10 to 20% by weight of acrylic binder. And a minor component consisting of 1 to 3% by weight of a fragrance, 1 to 4% by weight of castor oil, 1 to 2% by weight of an emulsifier, 1 to 2% by weight of a penetrant, and 1% by weight of a thickener, which are common additives, It is prepared by mixing with the residual amount of water except the composition ratio.

Anion powder refers to the invisible fine particles with an electric powder, blood purification, cell reactivation, immunity increase action, autonomic nervous system action and pain relief is known. At this time, if the natural mineral material that can emit an anion of 700 ~ 1,000 A / cc, which is the most appropriate amount for the human body can be used, typically tourmaline, heguson, cheonggi and the like. In addition, at least one metal element emitting anion is preferably selected from the group consisting of selenium, silicon, zinc, silver, iron, phosphorus and sulfur. In particular, in the composition for analgesic relief of musculoskeletal disorders of the present invention, the anionic powder performs a function of lowering the toxicity of capsaicin. At this time, the preferred amount is 5 to 15% by weight, more preferably 5 to 10% by weight. In the case of using less than 5% by weight of anionic powder, the anion generation rate is low, while when more than 15% by weight, there are disadvantages such as touch or color of the product, and troubles in the work process.

The capsaicin medicament preferably contains 1,500,000 to 3,000,000 IU of capsaicin, and more preferably 2,500,000 to 3,000,000 IU. At this time, in the case of containing capsaicin less than 1,500,000 IU, the function of the drug is weak, which is not preferable, while containing capsaicin in excess of 3,000,000 IU, there is a difficulty in manufacturing or purchasing.

The capsaicin medicament containing the above content is used in sustained release, capsule form or a mixture thereof impregnated into silica. More preferably, it is a mixture of a sustained-release form and a capsule form in which capsaicin is impregnated inside the silica, and in this case, the degree of destruction of the capsule is lower than that of the capsule form alone, resulting in a longer life of the processing agent containing the capsaicin, and thus durability of washing. This is improved. The sustained-release agent is prepared in a sustained-release form by impregnating capsaicin inside the porous silica, and then post-processing the low-temperature curable urethane on the surface of the silica.

Capsaicin is extracted from red pepper with ethanol using conventional methods [DJ Bennet, EW Kirby, J. Chem. Soc. C, 442, 1968, commercially available ones may be selected and used.

Because capsaicin has a high caloric value and a high heat generation property, capsaicin can impart a hot feeling to the skin with only a small amount of chemical use. Thus, the amount of energy transferred to the skin through the surface of silica increases, thereby improving skin smoothness. It has a higher advantage than other drugs. Therefore, the preferred amount of capsaicin that can be used in the composition of the present invention is 4 to 8% by weight, when less than 4% by weight, the analgesic effect is not satisfactory, and when it exceeds 8% by weight, the exothermicity is excessively long. It is difficult to use, and the strong smell of capsaicin can cause a rejection to the user by lowering the image of the product. When the capsaicin medicament is used in a mixed release in a sustained-release form and a capsule form in which the capsaicin is impregnated in the silica, it is more preferable to use the same amount.

In addition, the composition for analgesic relief of musculoskeletal disorders of the present invention may further contain 0.5 to 5 ppm of platinum. Platinum increases the fever function of the capsaicin drug in addition to the known eradication effects of tick bacteria [Derasawa Mizuo and Akagi Sugahara, Paper title: the increase and decrease of ticks and anion when anion is generated in a family house] Let's do it. In addition, the generation of static electricity is suppressed and the conductivity increases and the frictional voltage is lowered, thereby giving a feature of lowering skin stress. At this time, when the platinum is less than 0.5 ppm, the weak wave of the anionic drug, when used in excess of 5 ppm, there is an uneconomical problem due to the use of expensive platinum.

The composition of the present invention, using 3 to 20% by weight of the urethane-based binder and 10 to 20% by weight of the acrylic binder, the viscosity of the total composition is prepared from 30,000 to 40,000 cps. The urethane-based binder and the acrylic binder may be used without particular limitation as long as they are normally used, and the amount of the urethane binder and the acrylic binder may also be varied within a range capable of adjusting the viscosity of the entire composition. At this time, if the viscosity of the total composition is less than 30,000cps, there is a problem that the drying time is long and the adhesion decreases when the composition is applied, and when the viscosity of the total composition is more than 40,000 cps, screen shagging and difficulty of work, productivity is lowered Difficulties follow

In addition, the composition for analgesic relief of musculoskeletal disorders of the present invention may further use conventional emulsifiers, penetrants, thickeners, fragrances, and water.

The composition for relieving analgesic of musculoskeletal disorders of the present invention can be applied to fibers that can directly contact the body. The fibers may be nylon yarn processed fibers such as polytrimethylene terephthalate (PTT) fibers, cotton fibers, mixed fibers of cotton and polyester, nylon fibers, nylon / PTT lycra fibers and the like. In more detail, the application field may include silver underwear, hypertension or stroke patient underwear or patient clothing, waist protector, knee protector and the like for the elderly who complain of shoulder pain such as knee, back pain and fifty shoulders. Applicable It can also be applied to training clothes, sports clothing for diet using the exothermic action of the composition.

Thus, the present invention provides a functional socks prepared by printing the bottom surface of the socks in contact with the skin using the composition for analgesic relief of the musculoskeletal disorders.

The present invention provides a functional sock containing the composition as an active ingredient.

In addition, the present invention comprises the steps of preparing a composition of the present invention having a viscosity of 30,000 to 40,000 cps; Socks woven from any one of the fibers selected from the group consisting of polytrimethylene terephthalate (PTT) fibers, cotton fibers, mixed fibers of cotton and polyester, nylon yarn processed fibers including nylon fibers and nylon / PTT lycra fibers Preparing a; Coating the prepared composition on the inner bottom surface of the sock; Drying at 130 to 140 ° C. for 30 seconds; And heat setting at 170 ° C. to 175 ° C. for 30 seconds. It provides a method for producing a functional socks consisting of.

More specifically, the manufacturing method of the functional socks is poured the composition having a viscosity of 30,000 to 40,000 cps to the screen sha of the circular flat blade, and the woven socks are fixed to the aluminum plate. After closely contacting the screen shasa and the bottom of the socks, the composition is applied to the bottom of the socks with a rubber yarn that maintains a squeegeeing speed at 18 to 20 times / minute, and the hydraulic pressure is adjusted to lower or increase the penetration of the composition. The printing pattern of the product is formed. At this time, the temperature of the circular flat blade zone is dried for 30 seconds at 130 ~ 140 ℃, and packaged by heat setting to secondary processing for 30 seconds at 170 ℃ to 175 ℃.

1 is a photograph of the surface of the bottom of the socks prepared according to the manufacturing method of the present invention by scanning electron microscopy, it is confirmed that the capsaicin in the composition of the present invention is stably attached to the surface of the socks in the form of a capsule. In addition, FIG. 2 is a photograph of the prepared socks after washing five times, ten times, fifteen times, and twenty times, and the surface of the bottom of the socks was observed by scanning electron microscopy, and it was confirmed that the capsaicin dropout rate attached to the surface was very low. have. In addition, the remaining amount of capsaicin on the surface after washing up to 50 times, the functional socks of the present invention is excellent in washing resistance and durability can give a long time effect.

Hereinafter, the present invention will be described in more detail with reference to Examples.

This embodiment is intended to illustrate the present invention in more detail, and the scope of the present invention is not limited to these examples.

Example 1 Preparation of Composition 1

The following components were mixed and sufficiently emulsified and dispersed to prepare a composition 1 for analgesic relief of musculoskeletal disorders having a viscosity of 30,000 cps on an aqueous mixed binder. The medicament containing capsaicin contains 1,500,000 to 2,000,000 IU capsaicin components, and the capsule and sustained release forms were mixed. The sustained-release drug was prepared in a sustained-release form by impregnating 400 g of an oily capsaicin stock solution in 100 g of porous silica, followed by post-processing a low temperature curable urethane on the surface of the silica.

The components of the composition are as follows.

Anion Powder ............................... 10 wt%

Capsule-type medicament containing capsaicin ............ 2 wt%

Sustained-release drugs containing capsaicin ............... 2% by weight

Peppermint Peppermint Capsule ........................................ 3% by weight

Urethane Binder ............................................... 20 wt%

Non-Toxic Acrylic Binder .................................... 20 wt%

Nano Platinum Particles ............................................ 0.5 ppm

Castor Oil ... 4 wt%

Emulsifiers ... ... 2% by weight

Penetrating Agent ... ... 2% by weight

Thickener ... ... 1% by weight

Water ... ....... remaining amount

Example 2 Preparation of Composition 2

In the composition of Example 1, using the same composition as in Example 1, except that the drug containing the capsaicin is 4% by weight of the sustained-release drug alone containing 2,500,000 to 3,000,000 IU of the capsaicin component To prepare a composition 2 for analgesic relief of musculoskeletal disorders having a viscosity of 35,000 cps.

Example 3 Preparation of Composition 3

In Example 1, except that the nano platinum particles were not added, using the same composition as in Example 1 to prepare a composition 3 for analgesic relief of musculoskeletal disorders having a viscosity of 35,000 cps.

Example 4 Manufacture of Socks

The composition prepared in Example 1 is poured into a screen sachet of a circular flat blade, and the sock woven with polytrimethylene terephthalate (PTT) is fixed to an aluminum plate, when the bottom of the screen and the sock are in close contact. , So that the inner bottom of the socks are touching. After adhesion, the rubber yarn maintained at the squeegeeing speed at 20 times / minute was used, and the hydraulic pressure was adjusted to lower or increase the penetration of the composition to apply evenly to the inner bottom of the socks to form a printing pattern of the product. . At this time, the temperature of the circular flat blade zone was set to 135 ℃ and then dried for 30 seconds, and heat set for 30 seconds at 170 ℃ to 175 ℃.

Experimental Example 1

In order to observe the characteristics of the functional socks prepared in Example 4 was tested as follows.

1. Laundry resistance and durability test

The surface of the functional socks prepared in Example 4 was observed by magnifying 100 times using a scanning electron microscope (MODEL: JSM-5510). After washing 5 times, 10 times, 15 times and 20 times, the surface of the socks was observed in the same manner.

As a result of the experiment, the capsaicin in the composition of the present invention was stably attached to the surface to be attached in the form of a capsule (Fig. 1), the capsaicin dropout rate was very low on the surface attached even after a certain number of washing (Fig. 2). These results are shown in Table 1 as a result of the residual content of the silicon element and chlorine element detected on the surface.

       Content element Before washing After washing five times After washing 10 times After 15 washes After washing 20 times Si 11.53 13.06 12.58 12.14 18.01 Cl 88.47 86.94 87.42 87.86 81.99

As shown in Table 1, the residual content of the chlorine element after 20 washes showed only less than 10% reduction than the initial case, it was confirmed that the excellent washing resistance and durability.

2. Antimicrobial Test

In order to perform the antimicrobial test of the functional socks prepared in Example 4, the results were carried out by ATCC 6538P, ATCC 4352 method, 99.9% of the antimicrobial activity was confirmed, Staphylococcus aureus (ATCC 6538P), pneumococcal (ATCC 4352) experiment 99.9%.

3. Silver ion release experiment

For the functional socks prepared in Example 4, the anion release test was carried out by the KFIA-FI-1042 method, it was confirmed that 736 / cc.

4. Deodorization Experiment

With respect to the functional socks prepared in Example 4, as a result of the deodorization experiment A-33305 (detector tube) method, it was confirmed that more than 82% deodorization.

5. Friction band voltage test

The functional socks manufactured in Example 4 were tested using a conventional friction band voltage measurement method. At this time, the measurement temperature was performed at 20 ± 2 ℃, 40 ± 2% R.H, and 400 rpm conditions.

The frictional voltage refers to the generation of static electricity generated by friction, and the lower the frictional voltage, the lower the skin stress. As a result of the experiment, the friction band voltage for the functional socks manufactured in Example 4 was measured to 100 or less.

As a result of the above, the composition of the present invention contains a high amount of calories, high exothermic ability to contain a capsaicin that can impart a hot feeling of the skin (Hot) even with a small amount of the drug, and an appropriate amount of addition to minimize the rejection when applying the capsaicin And by adjusting the composition, to provide a functional socks suitable for analgesic relief of musculoskeletal disorders,

By using this composition, it can be applied to topical treatment guards such as silver underwear, hypertension or stroke patient underwear or patient clothing, waist protector, knee protector for the elderly who complain of shoulder pain such as knee, back pain, and fifty shoulders. There is,

It can also be applied to training clothes, sports clothing for diet using the exothermic action of the composition.

Although the present invention has been described in detail only with respect to the described embodiments, it will be apparent to those skilled in the art that various modifications and variations are possible within the scope of the technical idea of the present invention, and such modifications and modifications belong to the appended claims. .

Claims (9)

5-15% by weight of anionic powder, 4-8% by weight of capsaicin, 3-20% by weight of urethane binder and 10-20% by weight of acrylic binder, and It consists of the subcomponent which consists of 1 to 3 weight% of fragrance | flavor which is a usual additive, 1 to 4 weight% of castor oil, 1 to 2 weight% of emulsifier, 1 to 2 weight% of penetrants, and 1 weight% of thickeners, and the composition ratio of the said main component and subcomponents Skeletal pain relief composition, which is prepared by mixing with a residual amount of water except for. According to claim 1, wherein the composition further comprises 0.5 to 5 ppm of platinum composition for analgesic relief of the musculoskeletal disorders, characterized in that. According to claim 1, wherein the viscosity of the composition is characterized in that 30,000 to 40,000 cps, the composition for analgesic relief of the musculoskeletal disorders. The composition of claim 1, wherein the capsaicin drug contains 1,500,000 to 3,000,000 IU of capsaicin. The method of claim 1, wherein the capsaicin agent is a single form selected from sustained release or capsule form impregnated with silica; Or a mixture thereof; a composition for relieving analgesic of the musculoskeletal disorders, characterized in that. The composition of claim 1, wherein the anion powder is at least one selected from the group consisting of selenium, silicon, zinc, iron, phosphorus and sulfur. Functional socks, characterized in that produced by printing the bottom surface of the socks in contact with the skin using the composition for analgesic relief of musculoskeletal disorders of claim 1. The composition for analgesic relief of musculoskeletal disorders of claim 1, wherein the composition comprises nylon trimmed fibers including polytrimethylene terephthalate (PTT) fiber, cotton fiber, cotton and polyester mixed fiber, nylon fiber and nylon / PTT lycra fiber Functional clothing, characterized in that applied to any one selected fibers. Preparing a composition of claim 1 having a viscosity of 30,000 to 40,000 cps; Prepare a sock woven from any one of the fibers selected from the group consisting of polytrimethylene terephthalate (PTT) fibers, cotton fibers, cotton and polyester mixed fibers, nylon fibers and nylon yarn processed fibers including nylon / PTT lycra fibers Doing; Coating the prepared composition on the inner bottom surface of the sock; Drying at 130 to 140 ° C. for 30 seconds; And Heat setting for 30 seconds at 170 ℃ to 175 ℃; manufacturing method of the functional socks, characterized in that consisting of.

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