KR100583674B1 - Multilayed three-dimensional foamed Polymeric Gel containing functional medicine and Its Preparation Method - Google Patents

Abstract

The present invention relates to a multi-layered stereoscopic foam polymer gel having a porosity containing a functional agent and a method for producing the same. Since the polymer gel used for conventional medical purposes has a planar structure, when attached to a curved body part, not only the shape stability is lowered but also the swelling degree is low and the porosity is not controlled on the surface and inside. In the present invention, using a polymer that is used as a biomaterial is harmless to humans and absorbs poisons, silver particles, anti-inflammatory agents and allantoin, azene, licorice acid, etc. It provides a multi-layered three-dimensional foam polymer gel having a porous structure.

Multi-layered structure, foamed polymer gel, porous, high swelling, functional drug

Description

Multi-layered three-dimensional foamed polymeric gel containing functional medicine and Its Preparation Method}

1 is a schematic diagram of a multi-layered three-dimensional structure foam polymer gel having a porosity containing the functional agent of the present invention

Figure 2 is an electron scanning micrograph of a multi-layered three-dimensional foam foam polymer gel having a porosity containing the functional agent (silver particles) of the present invention

The present invention provides a polymer gel having a special three-dimensional shape so that the polymer gel that is used as a biomaterial can be easily used for medical purposes in a curve showing part of the body part.

The present invention relates to a multi-layered stereoscopic foam polymer gel having a porosity containing a functional agent and a method for producing the same.

It is another object of the present invention to provide a polymer gel having a foam-type multilayer stereoscopic structure that solves the degradation of the morphological stability of the polymer gel having a planar structure used for conventional medical use.

Still another object of the present invention is to provide a foam-type polymer gel having a high swelling degree and having a multi-layered stereoscopic structure in which porosity is controlled on the surface and the inside thereof.

It is another object of the present invention to the foam-type polymer gel having a multi-layered three-dimensional structure harmless to the human body and absorbs poisons, silver particles, anti-inflammatory agents and allergic to human body such as allantoin, azene, licoriceic acid, etc. It is to provide a multi-layered three-dimensional foam foam polymer gel having a porous structure containing a functional drug to.

Another object of the present invention is to incorporate a therapeutic agent for the purpose of the porous polymer gel having a three-dimensional structure to be applied to the patch to be contacted or adhered to the skin or mucous membranes can be continuously absorbed by the human body, than the conventional method It is to provide a multi-layered three-dimensional foam polymer gel and a method for producing the same to have an excellent sustained release and drug sustaining effect.

Hydrogels are polymers that swell by water and are produced by physical and chemical crosslinking of hydrophilic polymers. Hydrogels formed by physical crosslinking can reversibly sol and gel transition according to changes in the external environment, but chemically crosslinked hydrogels can be irreversibly returned to the sol state. It becomes a gel in its absence (Peppas N., Hydrogels in Medicine and Pharmacy, CRC Press, 1987).

In general, biomaterials may be classified in various ways according to their properties. Most commonly, they are classified according to the type of material, which is largely divided into inorganic and organic materials, and inorganic materials are divided into metal and ceramic. Organic materials are mainly polymers, and plastics, rubbers, fibers, coating materials, adhesives, and the like. In addition, there is a class of composite materials between polymers and materials having different properties such as polymers and metals, polymers and ceramics. In particular, the use of a polymer in the biomaterial has the advantage that the elasticity and resilience is superior to the metal or ceramic, and is relatively easy to manufacture and light. (Park J. B., Biomaterials Science and Engineering, Plenum Press, 1984)

However, the conventional biopolymer gel is mainly made in a planar shape, and when it is manufactured as a patch for medical use on the curved part of the body, it has a disadvantage of poor shape stability and poor adhesion. The degree of using the planar polymer gel as it is, a polymer gel having the desired physical properties could not be obtained. That is, in the case of the patch used as a matrix containing a drug having a structure that can be easily attached and detached to the curve showing part of the body, and can contain drugs, porous polymer gel used as a conventional microbial carrier Silver had a planar structure, and the porosity was small, so that the shape stability during adhesion and desorption where the curve was shown in the body parts was not excellent, and there was a disadvantage that it could not contain a solution such as an aqueous solution containing a sufficient amount of drug.

Therefore, the present inventors use a variety of physical properties of the polymer gel that is used as a biomaterial for use in new medical purposes, for example, a patch such as dressing agents, insulin patches, motion sickness patches, etc. so that it can be easily used where the curve of the body parts The inventors sought ways to be used as a matrix material for use, including a drug for use, or as a support for medical devices inserted into the human body.

Therefore, as a result of research to solve the above shortcomings, the polymer gel is designed to have a three-dimensional structure rather than a planar structure, and has the idea that it is easily attached to a non-planar part of the body part, freezing and thawing after gel production Thawing) or lyophilization to prepare a multi-layered three-dimensional foam polymer gel having a porous structure. In addition, by using a freezing method, which is a physical crosslinking method, a foamed polymer gel having a porous structure can be more efficiently produced. As a result, the inventors can easily attach to curved body parts as a result of repeated studies. And excellent porous structure stability and subsequent incorporation of drugs advantageously designed to be a three-dimensional structure and to control the porous structure of the polymer gel has been accomplished the present invention.

Particularly, according to the present invention, the polymer gel may be used alone, but in some cases, each layer has a unique structure and a multi-layer structure is laminated so as to maximize the effect. After incorporation of the drug by coating or coating method, it was possible to form a stable gel by freezing at a cross-linking agent or below freezing temperature.

The inventors have conducted studies to solve the above problems, and as a result, the morphological stability and the porous structure stability in the production of gels and foams having a three-dimensional structure such as a cup type or a ring type and having a single or multilayer structure Excellent and subsequent drug incorporation advantageously not only controls the porous structure of the polymer gel, but also increases the size of the porosity and maximizes the swelling properties to maximize the incorporation of the target material to be used as a component of a dressing agent or patch. In the case of preparing a multi-layered three-dimensional polymer gel having a porosity containing a functional drug to facilitate the incorporation of drugs and enable the continuous absorption of the drug.

In other words, when a target disease treatment agent is incorporated into a porous polymer gel having a three-dimensional structure and applied to a patch to contact or adhere to the skin or mucous membranes, it can be continuously absorbed by the human body. Expected to have. In particular, the polymers used as biomaterials were laminated in layers to maximize the effect.

     Highly swellable porous multi-layered conformal foam polymer gel having a porosity of 50-1000 μm, more preferably 150-800 μm as a porous multi-layered conformal foam polymer gel having high swellability of 600 times or more Provided.

      In order to achieve the above structure, the present invention provides a multi-layered three-dimensional foam foam polymer gel having a porosity containing a functional agent and a method for producing the same, first, polyhydroxyethyl as a polymer used to prepare a polymer gel Methacrylate (PHEMA), polyacrylamide (PAAM), polymethacrylic acid (PMAA), polymaleic hydride (PMAH), polyvinyl alcohol (PVA), polyethylene oxide (PEO), polyvinylpyrrolidone ( PNVP), Polyglycolic Acid (PGA), Polylactic-Glycolic Acid (PLGA), Chitosan, Alginate, Polyurethane (PU), Polyethylene (PE), Polypropylene (PP), Polyvinyl Chloride (PVC) , Polyesters (PET), acrylic polymers and polyamides, polyhydroxyethyl methacrylate (PHEMA), polyacrylamide (PAAM), polymethacrylate, which are made of hydrophilic monomers to produce hydrogels It uses at least one selected from lactic acid (PMAA), polymaleic hydride (PMAH), polyvinyl alcohol (PVA), polyethylene oxide (PEO), polyvinylpyrrolidone (PNVP). Particles and silver particles, non-steroidal anti-inflammatory agents such as prefensolone, allentoin, azlene, etc. One or more selected from agents that have beneficial effects on the human body, such as licorice acid and anti-inflammatory agents.

Using the polymer, after dissolving the polymer in each solvent to produce a gel, it is designed to have a three-dimensional structure using a specially designed framework. At this time, the polymer gel used as each biomaterial may be used alone, but in some cases, each polymer gel may be laminated to have a multi-layer structure while having a unique structure to maximize the effect. Incorporating the drug by applying or coating a functional agent on the layer, and then forming a stable gel by freezing at a cross-linking agent or below freezing temperature, and foaming method by mixing water, gas or mixing of water and gas. It is a means that can be injected by injection into a mold of a certain shape to foam, or it can freeze at a temperature below a certain point of the solvent, preferably, a freezing temperature of minus 3-90 degrees. By adjusting the number of freezing / thawing 1 to 10 times or freeze-drying, the diameter of 50 ~ 1,000㎛, the swelling degree more than 600 times To prepare a multi-layer three-dimensional structure pomhyeong polymer gel having a porous structure satisfying the physical properties having the Yun, Seong the same time, and completed the present invention.

Hereinafter, the present invention will be described in detail.

In the present invention, each polymer used as a biomaterial has a multi-layered three-dimensional structure such as a cup or a ring, and in order to prepare a foam-type polymer gel having a porous structure, each polymer may be a solvent. After dissolving in gel, it is designed to have a three-dimensional structure using a specially designed frame. In this case, the polymer gel used as the biomaterial may be used alone, but in some cases, each polymer gel layer may be laminated on each polymer gel layer before and after gel formation by stacking the layers to have a multi-layered structure with a unique structure to maximize the effect. After incorporating the drug by applying or coating the functional agent, a stable gel is formed by using a crosslinking agent of 0.01g-0.8g per 1g of the polymer weight or by freezing at a sub-zero temperature, and mixing water, gas, or water by the foaming method. It is a method to inject into a mold of a certain form by incorporating the mixing of gas and gas, and to maintain a stable porous structure made by foaming, forming, and freezing of drugs. It is manufactured by adjusting the number of freezing and thawing 1-10 times or freeze-drying. A porous polymer gel having a foam and gel structure having a high swellability of 0 to 1,000 µm and a swelling degree of 600 times or more and more preferably satisfying a property of high swelling of 150 to 800 µm in diameter and 800 times or more of swelling degree can be prepared. The foam-type polymer gel suitable for the use of the dressing agent, patch, etc. of this invention, or the support body of the medical instrument for human insertion was obtained.

The following describes the production method of the present invention.

First, dissolve each polymer in each solvent, and then use a crosslinking agent or by controlling the number of freezing and thawing to pour into a specially designed mold to prepare a polymer gel having a three-dimensional structure such as cup or ring. do. In addition, it was possible to control the microporosity by using the lyophilization method, it is possible to produce a layer of each polymer gel, that is, to produce a multi-layered polymer gel layered.

The blowing agent uses water as a chemical blowing agent because it foams in carbon dioxide produced by reaction with water using the activity of an isocyanate group, and forms bubbles by incorporating gas as a physical blowing agent or by generating heat of reaction using a heat of decomposition or an evaporative blowing agent. . Therefore, in the present invention, any of the above methods may be used, but in the case of using a chemical foaming agent, the reaction product may be mixed by the foaming agent after foaming, so that the physical foaming agent is mixed with water, gas, or water and gas It is better to use the method of merging incorporation.

Chemical crosslinking agents used to crosslink polymers include ethylene glycol dimethacrylate (EGDM), boric acid, dialdehydes, dicarboxylic acids, dianhydrides, acid chlorides, epichlorohighs. A gel can be formed using a bifunctional crosslinking agent such as Drin. In the present invention, a method of chemical crosslinking using 0.01-0.8g per 1g of polymer as a chemical crosslinking agent or the temperature or the number of times of freezing and thawing By controlling the cross-linking by a physical method such as the control and freeze-drying method or by using a mixture of chemical and physical methods it was possible to prepare a three-dimensional foam polymer polymer having an excellent porous structure.

In using the physical method, the freezing method may be given a freezing time of 2 hours or more at -3 ° C to -90 ° C. If the temperature is higher than this or the time is short, it is difficult to form a large porous gel, and if the time is short, the swelling property is low. Therefore, the dressing or patch corresponding to the use of the present invention for the purpose of the present invention. In addition, it is difficult to obtain a highly swellable high porous polymer gel suitable for applications that require high swellability, such as a support for human-insertable medical devices.

The obtained polymer foams and gels were measured for physical properties in the following manner, and the physical properties according to the results of the following examples are shown in Table 1.

① Swelling%

The polymer gel dressing having a three-dimensional structure was taken in a size of 4cm × 3cm and dried in an oven at 80 ° C. for 60 hours, and then the weight increase was calculated to calculate the swelling degree. At this time, the dried polyvinyl alcohol gel was immersed in distilled water at 37 ° C. for 72 hours, taken out, and then the surface was dried to determine the weight.

                         Swelling% = (Y-X) / X × 100

  Initial weight (after drying) = X

  Weight after immersion = Y

② Cell size

Scanning electron microscopy (SEM, Cambridge 360) and optical microscopy were used to observe the pore size of the surface and cross-section of the foamed polyvinyl alcohol gel.

Hereinafter, the present invention will be described with reference to Examples and Comparative Examples, but these are provided to explain the present invention in detail, and the technical scope of the present invention is not limited thereto.

Example 1

10 g of distilled water per 1 g of polyacrylamide (PAAM) is completely dissolved, and 0.01 g of silver particles is added thereto. The freezing temperature was adjusted to minus 30 ℃, and the freezing time was adjusted to 10 hours to prepare a polyacrylamide gel. At this time, since the solution was poured into a cup-shaped specially designed mold and frozen, the gel produced was formed in a cup-shaped gel. 15 g of distilled water per 1 g of polyvinyl alcohol (PVA) was added to the prepared cup-type polyacrylamide gel, and the dissolved solution was poured and frozen. Again 0.01 g of silver particles are added. At this time, by controlling the freezing temperature to minus 30 ℃, the freezing time was adjusted to 10 hours to prepare a hydrogel consisting of a two-layer structure of cup-type polyacrylamide / polyvinyl alcohol. The cup-shaped two-layer gel containing silver particles prepared was lyophilized at 60 ° C. for 48 hours to prepare a two-layer gel having a porous structure having a diameter of 100 to 500 μm (average diameter of 280 μm). The swelling degree calculated by immersing in 37 ° C. distilled water for 72 hours and then removing the surface was 840%. After swelling, the cup-shaped shape was maintained as it was, showing excellent shape stability.

Example 2

10 g of distilled water per 1 g of polyacrylamide (PAAM) is completely dissolved, and 0.01 g of silver particles is added thereto. The freezing temperature was adjusted to minus 30 ℃, and the freezing time was adjusted to 10 hours to prepare a polyacrylamide gel. At this time, since the solution was poured into a cup-shaped specially designed mold and frozen, the gel produced was formed in a cup-shaped gel. 20 g of distilled water per 1 g of polymethacrylic acid (PMAA) was added to the prepared cup-type polyacrylamide gel, and the dissolved solution was poured and frozen. In addition, 0.01 g of silver particles are added. At this time, by controlling the freezing temperature to minus 30 ℃, the freezing time was adjusted to 10 hours to prepare a hydrogel consisting of a two-layer structure of cup-type polyacrylamide / polymethacrylic acid. The cup-type two-layer gel containing silver particles thus prepared was lyophilized at 60 ° C. for 48 hours to prepare a two-layer gel having a porous structure having a diameter of 100 to 700 μm (average diameter of 380 μm). The swelling degree calculated by immersing in 37 ° C. distilled water for 72 hours and then removing the surface was 650%. After swelling, the cup-shaped shape was maintained as it was, showing excellent shape stability.

Example 3

10 g of distilled water per 1 g of polyacrylamide (PAAM) is completely dissolved, and then 0.01 g of predrisolone is added. The freezing temperature was adjusted to minus 30 ℃, and the freezing time was adjusted to 10 hours to prepare a polyacrylamide gel. At this time, since the solution was poured into a cup-shaped specially designed mold and frozen, the gel produced was formed in a cup-shaped gel. 15 g of distilled water per 1 g of polyvinyl alcohol (PVA) was added to the prepared cup-type polyacrylamide gel, and the dissolved solution was poured and frozen. In addition, 0.01 g of Predrisolone (Anti-inflammatory) is added. At this time, by controlling the freezing temperature to minus 30 ℃, the freezing time was adjusted to 10 hours to prepare a hydrogel consisting of a two-layer structure of cup-type polyacrylamide / polyvinyl alcohol. 20 g of distilled water per 1 g of polymethacrylic acid (PMAA) was added to the prepared cup-type two-layer structure gel, and the dissolved solution was poured and frozen. At this time, by controlling the freezing temperature to minus 30 ℃, the freezing time was adjusted to 10 hours to prepare a hydrogel consisting of a three-layer structure of cup-type polyacrylamide / polyvinyl alcohol / polymethacrylic acid. The cup-type three-layer gel containing the anti-inflammatory agent was lyophilized at 70 ° C. for 48 hours to prepare a three-layer gel having a porous structure having a diameter of 100 to 660 μm (average diameter of 320 μm). The swelling degree calculated by immersing in 37 ° C. distilled water for 72 hours and then removing the surface was 940%. After swelling, the cup-shaped shape was maintained as it was, showing excellent shape stability.

Example 4

10 g of distilled water per 1 g of polyacrylamide (PAAM) is completely dissolved, and then 0.01 g of predrisolone (Anti-inflammatory) is added. The freezing temperature was adjusted to minus 30 ℃, and the freezing time was adjusted to 10 hours to prepare a polyacrylamide gel. At this time, since the solution was poured into a ring-type specially designed mold and frozen, the gel produced had a ring-shaped gel. 15 g of distilled water per 1 g of polyvinyl alcohol (PVA) was added to the prepared ring-type polyacrylamide gel, and the dissolved solution was poured and frozen. In addition, 0.01 g of Predrisolone (Anti-inflammatory) is added. At this time, by controlling the freezing temperature to minus 30 ℃, the freezing time was adjusted to 10 hours to prepare a hydrogel consisting of a two-layer structure of ring-type polyacrylamide / polyvinyl alcohol. 20 g of distilled water per 1 g of polymethacrylic acid (PMAA) was added to the prepared ring-type two-layer gel, and the solution was completely poured and frozen. At this time, by controlling the freezing temperature to minus 30 ℃, the freezing time was adjusted to 10 hours to prepare a hydrogel consisting of a three-layer structure of ring-type polyacrylamide / polyvinyl alcohol / polymethacrylic acid. The ring-shaped three-layer gel containing the anti-inflammatory agent was lyophilized at 70 ° C. for 48 hours to prepare a three-layer gel having a porous structure having a diameter of 100 to 660 μm (average diameter of 310 μm). The swelling degree calculated by immersing in 37 ° C. distilled water for 72 hours and then removing the surface was 950%. Even after swelling, the ring-shaped shape was maintained as it was, showing excellent shape stability.

Example 5

10 g of distilled water per 1 g of polyacrylamide (PAAM) is completely dissolved, and then 0.01 g of predrisolone (Anti-inflammatory) is added. The freezing temperature was adjusted to minus 30 ℃, and the freezing time was adjusted to 10 hours to prepare a polyacrylamide gel. At this time, since the solution was poured into a ring-shaped specially designed mold and frozen, a gel of a ring shape was formed. 10 g of distilled water per 1 g of polyvinyl pyrrolidone (PNVP) was put on the prepared ring-type polyacrylamide gel, and the solution was completely poured and frozen. In addition, 0.01 g of Predrisolone (Anti-inflammatory) is added. At this time, by controlling the freezing temperature to minus 30 ℃, the freezing time was adjusted to 10 hours to prepare a hydrogel consisting of a two-layer structure of ring-type polyacrylamide / polyvinyl pyrrolidone. 20 g of distilled water per 1 g of polymethacrylic acid (PMAA) was added to the prepared ring-type two-layer gel, and the solution was completely poured and frozen. At this time, by controlling the freezing temperature to minus 30 ℃, the freezing time was adjusted to 10 hours to prepare a hydrogel consisting of a three-layer structure of ring-type polyacrylamide / polyvinyl pyrrolidone / polymethacrylic acid. The ring-shaped three-layer gel containing the anti-inflammatory agent was lyophilized at 70 ° C. for 48 hours to prepare a three-layer gel having a porous structure having a diameter of 100 to 830 μm (average diameter of 450 μm). The swelling degree calculated by immersing in 37 ° C. distilled water for 72 hours and then removing the surface was 820%. Even after swelling, the ring-shaped shape was maintained as it was, showing excellent shape stability.

Example 6

       10 g of distilled water per 1 g of polyacrylamide (PAAM) is completely dissolved, and then 0.01 g of predrisolone (Anti-inflammatory) is added. The freezing temperature was adjusted to minus 30 ℃, and the freezing time was adjusted to 10 hours to prepare a polyacrylamide gel. The freezing time was repeated five times with 10 hours. That is, frozen at minus 30 ℃ and thawed at room temperature 20 ℃. At this time, since the solution was poured into a cup-shaped specially designed mold and frozen, the gel produced was formed in a cup-shaped gel. 20 g of distilled water per 1 g of polymethacrylic acid (PMAA) was added to the prepared cup-type polyacrylamide gel, and the dissolved solution was poured and frozen. In addition, 0.01 g of Predrisolone (Anti-inflammatory) is added. At this time, by controlling the freezing temperature to minus 30 ℃, the freezing time was adjusted to 10 hours to prepare a hydrogel consisting of a two-layer structure of cup-type polyacrylamide / polymethacrylic acid. The freezing time was repeated five times with 10 hours. That is, frozen at minus 30 ℃ and thawed at room temperature 20 ℃. The cup-type two-layer gel containing the anti-inflammatory agent was lyophilized at 60 ° C. for 48 hours to prepare a two-layer gel having a porous structure with a diameter of 70 to 480 μm (average diameter of 250 μm). The swelling degree calculated by immersing in 37 ° C. distilled water for 72 hours and then removing the surface was 960%. After swelling, the cup-shaped shape was maintained as it was, showing excellent shape stability.

Example 7

  10 g of distilled water per 1 g of polyhydroxyethyl methacrylate (PHEMA) is completely dissolved, and 0.01 g of predrisolone, which is anti-inflammatory, is added. 0.2g of ethylene glycol dimethacrylate (EGDM), a chemical crosslinking agent, is crosslinked, mixed with water and gas, injected into a mold, foamed and molded, and the freezing temperature is controlled to -30 ° C. , The freezing time was adjusted to 10 hours to prepare a polyhydroxyethyl methacrylate gel. At this time, since the solution was poured into a cup-type specially designed mold and frozen, a gel of cup shape was formed. 15 g of distilled water per 1 g of polyvinyl alcohol (PVA) was added to the prepared cup-type polyhydroxyethyl methacrylate gel, and the dissolved solution was poured and frozen. In addition, 0.01 g of Predrisolone (Anti-inflammatory) is added. At this time, by controlling the freezing temperature to minus 30 ℃, the freezing time was adjusted to 10 hours to prepare a hydrogel consisting of a two-layer structure of cup-type polyhydroxyethyl methacrylate / polyvinyl alcohol. The cup-type two-layer gel containing the anti-inflammatory agent was lyophilized at 60 ° C. for 48 hours to prepare a two-layer gel having a porous structure having a diameter of 100 to 700 μm (average diameter of 380 μm). The swelling degree calculated by immersing in 37 ° C. distilled water for 72 hours and then removing the surface was 770%. After swelling, the cup-shaped shape was maintained as it was, showing excellent shape stability.

Comparative Example 1

10 g of distilled water per 1 g of polyacrylamide (PAAM) is completely dissolved, and then 0.01 g of predrisolone (Anti-inflammatory) is added. The freezing temperature was adjusted to minus 30 ℃, and the freezing time was adjusted to 10 hours to prepare a polyacrylamide gel. At this time, since the solution was poured into a container having a flat shape and frozen, a gel having a flat shape was formed. 15 g of distilled water per 1 g of polyvinyl alcohol (PVA) was added to the prepared flat polyacrylamide gel, and the dissolved solution was poured and frozen. In addition, 0.01 g of Predrisolone (Anti-inflammatory) is added. At this time, by controlling the freezing temperature to minus 30 ℃, the freezing time was adjusted to 10 hours to prepare a hydrogel consisting of a two-layer structure of the planar polyacrylamide / polyvinyl alcohol. The planar two-layer gel containing the anti-inflammatory agent was lyophilized at 60 ° C. for 48 hours to prepare a two-layer gel having a porous structure having a diameter of 100 to 500 μm (average diameter of 280 μm). The prepared planar two-layer gel was cupped, immersed in distilled water at 37 ° C. for 72 hours, and then drained to obtain a swelling degree of 790%. After swelling, the cup-shaped shape could not be maintained as it was, and the shape was more curved than the first flat shape, thereby showing no shape stability.

Comparative Example 2

10 g of distilled water per 1 g of polyacrylamide (PAAM) is completely dissolved, and then 0.01 g of predrisolone (Anti-inflammatory) is added. The freezing temperature was adjusted to minus 30 ℃, and the freezing time was adjusted to 10 hours to prepare a polyacrylamide gel. At this time, since the solution was poured into a container having a flat shape and frozen, a gel having a flat shape was formed. 15 g of distilled water per 1 g of polyvinyl alcohol (PVA) was added to the prepared flat polyacrylamide gel, and the dissolved solution was poured and frozen. In addition, 0.01 g of Predrisolone (Anti-inflammatory) is added. At this time, by controlling the freezing temperature to minus 30 ℃, the freezing time was adjusted to 10 hours to prepare a hydrogel consisting of a two-layer structure of the planar polyacrylamide / polyvinyl alcohol. The prepared planar two-layer gel was lyophilized at 60 ° C. for 48 hours to prepare a two-layer gel having a porous structure having a diameter of 100 to 500 μm (average diameter of 280 μm). The planar two-layer gel containing the anti-inflammatory agent was packed into a ring shape, immersed in distilled water at 37 ° C. for 72 hours, and then drained from the surface to obtain a swelling degree of 790%. After swelling, the shape of the ring shape was not maintained, and the shape was more curved than the initial plane shape, thereby showing no shape stability.

TABLE 1

As can be seen from the results in Table 1, a multi-layered gel was prepared in a cup and ring form using a specially designed frame, and finely porous when crosslinked using a freezing and thawing method. It has been shown to have a good degree of swelling. In addition, the shape stability designed to be easy to attach to the curve of the body parts was very excellent.

     On the other hand, in Comparative Examples 1 and 2, using a gel prepared in a planar shape to test the shape stability by artificially adhering to the cup-shaped or ring-shaped, it was found to have poor shape stability.

As can be seen from Table 1, the swelling degree and cell size of the polymer foam and the gel itself could be controlled by controlling the addition amount of various polymers and various raw materials. In particular, the polymer gel having a multi-layered structure containing a functional agent while having a three-dimensional structure such as a cup or a ring has a very good shape stability even after swelling. The multi-layered three-dimensional foam polymer gel having a porosity of the present invention is composed of a foam and a gel of an open cell structure of 50 to 1,000 ㎛ in diameter, preferably 150 to 800 ㎛, and at the same time has a high swelling ratio of 600 times or more. , A multi-layered three-dimensional foam polymer gel having a porosity was obtained. The multi-layered stereoscopic foam-type polymer gel prepared by the present invention may be used as a support for a medical device for inserting a human body as well as a dressing material or a drug carrier.

Claims (6)

Gold and silver particles, nonsteroidal anti-inflammatory agents such as prefensolone, allenin and azu It contains one or more functional drugs selected from drugs that have beneficial effects on the human body, such as len, licorice, and anti-inflammatory agents. It has a porous structure with an average diameter of 50 to 1,000 µm and has a cup or ring. Multi-layered three-dimensional foam polymer gel in which the foam polymer gel formed in a three-dimensional structure such as) is laminated.        The method of claim 1,       The multi-layered three-dimensional foam foam polymer gel having a porosity is polyhydroxyethyl methacrylate (PHEMA), polyacrylamide (PAAM), polymethacrylic acid (PMAA), polymaleic hydride (PMAH), polyvinyl alcohol ( PVA), polyethylene oxide (PEO), polyvinylpyrrolidone (PNVP), polyglycolic acid (PGA), polylactic-glycolic acid (PLGA), chitosan, alginate, polyurethane (PU), polyethylene (PE) ), Polypropylene (PP), polyvinyl chloride (PVC), polyester (PET), a multi-layered three-dimensional foam polymer gel prepared by at least one polymer component selected from acrylic polymer and polyamide. delete       (a) completely dissolving the polymer component in a solvent and then mixing the medicaments to prepare a mixed solution;       (b) crosslinking the mixed solution;      (c) Incorporating water and gas or mixing water and gas into a mold of a certain shape and foaming, and forming a three-dimensional polymer gel by lowering the temperature below a certain point of the solvent. Doing;      (d) repeating the steps (a) to (c) once to five times on the upper layer of the stereopolymer gel prepared in (c) to prepare a multi-layered three-dimensional foam polymer gel having porosity; Method for producing a multi-layered three-dimensional foam polymer gel having a.        The method of claim 4, wherein       The crosslinking step is chemical crosslinking agent ethylene glycol dimethacrylate (EGDM), boric acid, dialdehyde, dicarboxylic acid, dianhydride, acid chlorides, epichloro high Multi-layered solid prepared by adding 0.01 g-0.8 g of drin and adjusting the number of freeze and thaw 1-10 times at a freezing temperature of -3 ° C to -90 ° C and performing freeze-drying for 2 to 50 hours. Method for producing a structural foam polymer gel. The method of claim 4, wherein        The cross-linking step is a multi-layered three-dimensional foam foam polymer prepared by controlling the number of times of freezing and thawing 1-10 times the freezing and thawing of the polymer solution at a freezing temperature of -3 ℃ ~ -90 ℃ without a chemical crosslinking agent Method for preparing gels.

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