KR100511527B1 - Device and method for injecting biometerials using a drop on demand inkjet system - Google Patents

Abstract

The present invention provides a substrate preparation step (S100) for preparing a substrate, and the step of grinding the biomaterial particles to a size of about 1 μm by a collision grinding method (S201), and a predetermined ratio of biomaterial particles in distilled water Dispersion preparation step (S200) comprising a dispersion step of dispersing (S202) and a filtering step (S203) of removing foreign matter and excess particles in the dispersion, and an inkjet spraying step (S300) of inkjet-spraying the dispersion onto the substrate; And a thermal curing step (S400) of thermally curing the inkjet-sprayed substrate on the dispersion at a temperature of about 600 ° C., and a method of spraying a biocompatible material using an inkjet spraying device. Unlike the conventional plasma deposition method of depositing a substrate on a substrate, an expensive process such as making a vacuum can be omitted, and the initial investment cost is low due to the simple construction of the injection device. In addition, the non-contact method is less influenced by the surrounding environment (temperature, humidity, pressure, surface tension), and it is possible to realize a low-cost process, and it is possible to change materials quickly by exchanging storage containers, Since the adhesion and bio-friendly properties are good, it can be used in various fields such as the bio field, for example, orthopedic bone grafts, tissues, dental implants and the like.

Description

DEVICE AND METHOD FOR INJECTING BIOMETERIALS USING A DROP ON DEMAND INKJET SYSTEM}

The present invention relates to a spraying system and a spraying method of a biocompatible material, in particular a biocompatible material, particularly a hydroxide apatite (Hydroxy Apatite) material using the ink jet spraying system in accordance with the user's spraying demand Drop On Demand method preferably titanium, etc. The present invention relates to a biomaterial injector and an injection method using an inkjet ejection system for coating.

Metals such as stainless steel, cobalt-chromium alloys, and titanium-based alloys have excellent mechanical properties and machinability. It is used as a living material for replacing living tissue. By the way, the biggest problem in using these metals as a living implant material is that the biocompatibility is low.

In order to compensate for these disadvantages, a method of coating a biocompatible material, ie, hydroxyapatite, which is a kind of highly active ceramic material on the surface of the metal material, is generally used.

In order to coat apatite hydroxide on a metal substrate, conventionally spray spraying, sputtering, electron beam deposition, laser deposition, plasma spraying, and sol-gel A method of depositing an apatite hydroxide thin film on the surface of a metal substrate has been used. Among the various deposition methods described above, the most widely used method is the plasma spraying method.

This plasma spray method is a method mainly used for coating ceramic materials having a relatively high melting point, and is a method of dissolving apatite hydroxide powder with a plasma flame and spraying it onto a deposition target.

However, as described in Korean Patent Publication No. 1997-706610, a living body implant composite made of apatite hydroxide and metal prepared by a conventional plasma spraying method has the following problems.

First, in the living implant composite prepared by the conventional method, since the adhesive force between the metal substrate and the apatite hydroxide thin film is not large enough, there is a problem that it is insufficient to be used in the orthopedic or dental field.

Second, in the conventional plasma spraying method, as the apatite hydroxide powder is exposed to high temperature during the coating process, there is a disadvantage in that the structure and chemical composition are uneven.

Third, the apatite hydroxide thin film deposited on the surface of a metal substrate by various methods including a conventionally used plasma spraying method is generally amorphous, and has a problem of high solubility in the body.

In order to solve the problem of the high solubility of the apatite hydroxide thin film in the human body, a method of converting the amorphous structure of the apatite hydroxide thin film into a crystalline structure by heat treating the composite at a temperature of about 600 ° C. has been conventionally used. However, since the thermal expansion coefficients of the metal substrate and the apatite hydroxide thin film are different from each other, cracks are generated in the apatite hydroxide thin film during the thermal curing process, thereby causing a problem of deterioration in adhesion between the apatite hydroxide thin film and the metal substrate.

In addition, Japanese Patent Publication No. 2001 No. 259017 discusses the application of a thin film coating technique for the deposition of thin and adherent ceramic films. In the physical deposition method (PVD) such as RF sputtering, high quality of less than 10 μm is being studied. In order to coat the ceramic film, a separate expensive vacuum system is required, the process is complicated, and there is a problem in that rapid idea verification is difficult.

The Sol-Gel coating method has the advantage of simple process, but the disadvantage is that the coating thickness is too thin. Meanwhile, in the conventional spray coating method, a general ceramic coating is disclosed as disclosed in Korean Patent Publication No. 0083377, 2002. Compared to the plasma spray, chemical vapor deposition and sputtering used in the process, the process is very simple, no additional coating equipment is required, and complex shapes can be coated.However, the coating film is not uniform, such as agglomeration of spray materials. have.

Accordingly, the present invention has been made to solve the above problems, and an object of the present invention is to construct an inkjet injection system equipped with suitable hardware and software, and a light emitting resin, an adhesive, a solder, a thermosetting resin, a polymer, and apatite hydroxide. (Hydroxy Apatite), collagen and other materials to control the voltage waveform applied to the piezoelectric element by using an inkjet-jet system that can be sprayed in the desired shape, the system and method for spraying biocompatible materials such as apatite hydroxide or collagen To provide.

Compared to plasma spray, chemical vapor deposition and sputtering, the coating process of the biocompatible material is simpler, the initial investment cost for constructing the injection system is low, the structure and composition of the coated film is uniform, and the biocompatible material is The purpose of the present invention is to provide a method for spraying a biocompatible material using an inkjet injection system capable of quickly verifying that the coating is performed as desired by the user.

SUMMARY OF THE INVENTION An object of the present invention is to provide a method of spraying a biomaterial using an inkjet-spray system that forms a biomaterial coating film having a thickness required by a user by overcoming a disadvantage of a Sol-Gel coating method. .

The present invention is to overcome the disadvantages of the conventional spray method is to provide a biocompatible material spraying method in which the coating film is uniformly applied without agglomeration with each other.

The present invention can apply a biocompatible material as it is in the shape of the upper root of the root of a particular pattern coating, for example, dental implants, which was particularly difficult to implement by the various methods, It is also an object of the present invention to provide a biocompatible material injection method that can coat the upper and lower parts of the root with different biocompatible materials.

In order to achieve the object as described above, the biocompatible material injection system using the inkjet injection system according to the present invention was developed to spray the droplets of an aqueous fluid, that is, a solution in which various fine particles are dispersed. The biomaterial injection apparatus using the inkjet injection system according to the present invention comprises inkjet injection of a dispersion of distilled water of a pulverized biomaterial, and a liquid injection unit 20 including an injection nozzle 21 and an orifice 22; And a piezoelectric element driving unit 30 disposed on an outer circumferential surface of the liquid injection unit and configured to be expanded and contracted according to the voltage waveform generated by the piezoelectric element signal generator 32 to apply a piezoelectric driving force to the liquid injection unit. An observation unit 40 comprising an observation signal generator 41 and an observation signal receiver 42 to observe the shape of the dispersion droplets injected through the injection nozzle 21 and the orifice 21; and storing the biomaterial dispersion To control the initial pressure of the dispersion in the storage container 51 A pressure controller 50 and a stage driver 60 for setting the position of the substrate to be printed by the injector. It includes; thermosetting unit,

The liquid spraying unit 20 is characterized in that the dispersion droplet is sprayed in a demand-on manner to have the size, shape and spraying interval of the biocompatible material.

The biomaterial injection apparatus using the inkjet injection system according to the present invention is characterized in that it further comprises a thermosetting device.

In the method of spraying a biocompatible material using the inkjet injection system according to the present invention, the substrate preparation step (S100) of preparing a substrate and the step of grinding the biocompatible material particles to a size of about 1 μm by a collision grinding method (S201). And a dispersion preparation step (S200) comprising a dispersion step (S202) of dispersing a predetermined ratio of biocompatible material particles in distilled water and a filtering step (S203) of removing foreign substances and excess particles from the dispersion, and the dispersion on the substrate. Inkjet spraying to the inkjet spraying step (S300) and the dispersion is characterized in that it comprises a thermosetting step (S400) for thermal curing the inkjet-jetted substrate at a temperature of about 600 ℃.

Hereinafter, a biocompatible material spraying apparatus and a spraying method according to a first preferred embodiment of the present invention will be described in detail with reference to the accompanying drawings.

As shown in FIG. 1, the first embodiment of the biomaterial injector according to the present invention has a dispersion reservoir 51 for spraying a dispersion onto a flat substrate, an outer diameter of the nozzle 21, and a droplet of the dispersion is 1. And a liquid spray section 20 composed of an orifice 22 to be 占 퐉. The nozzle 21 is in fluid communication with the dispersion reservoir 51, and a piezoelectric element 31 is disposed on an outer circumferential surface of the nozzle 21. The piezoelectric element 31 allows the dispersion liquid to be sprayed from the nozzle 21 into a desired shape according to the applied voltage when the piezoelectric element control signal generator 32 is set to a predetermined condition.

The waveform below the X-Y stage 100 in FIG. 1 shows that the droplets of the dispersion jetted from the nozzles are disposed on the substrate 61 in response to the voltage waveform applied by the piezoelectric element control signal generator 32.

The pressure controller 50 for controlling the initial pressure of the dispersion liquid stored in the storage container so as not to flow down from the nozzle communicated from the storage container 51 will be briefly described with reference to FIG. 2. The pressure control unit 50 of the inkjet injection system controls the pressure or vacuum applied to the dispersion reservoir 51, the surface tension of the dispersion surface, the capillary phenomenon of the capillary tube communicating the reservoir 51 and the nozzle 21, and By balancing the imbalance between the hydraulic pressure to serve as a meniscus (Meniscus) so that the dispersion of the orifice 22 in the lower portion of the injection nozzle 21 according to the user's request does not flow down by gravity and maintain the crescent shape upward.

As shown in FIG. 2, the pressure controller 50 includes a first control unit 11 for checking air pressure, a second control unit 12 for checking vacuum pressure, and a level sensor 13 for checking the amount of dispersion of the nozzle. The pressure controller 50 controls the valve 14 and the air pump 15 based on data values input from the controller and the sensors 11, 12, and 13. That is, a constant positive pressure is provided to the storage container 51 through the first control unit 11, and a constant sound pressure is always maintained inside the nozzle by checking a sound pressure through the second control unit 12. The air pump 15 is to be controlled. When the dispersion of the nozzle drops as a result of the output of the level sensor 13, the pressure controller 50 operates the valve 14 and the air pump 15 to continuously discharge the dispersion from the dispersion storage container 51. To be supplied. By setting the pressure of the storage container 51 to 20PSI and the sound pressure of the nozzle 21 to 25PSI under optimum conditions, the droplets of the liquid dispersion do not flow freely from the orifice 22 of the nozzle 21 at the user's request. Be sure to Therefore, in the orifice 22, the meniscus is formed to be convex upward. The pressure control unit 50 may be operated at a higher temperature, but may be operated at room temperature, or may allow the temperature control unit 17 and the humidity control unit 18 to set temperature and humidity to room temperature and humidity. Dispersion is contained in the storage container 51 is replaceable.

In the first preferred embodiment, the optimum voltage applied from the piezoelectric element control signal generator 32 for driving the piezoelectric element 31 of the piezoelectric element driver 30 in the case of spraying the dispersion liquid onto the planar substrate. I will explain the waveform.

The drop-on-demand or on-demand injection method is a technical term that means that the user can inject various kinds of dispersion liquids using the inkjet injection system, and control the injection so as to spray in a desired pattern. Contrast term. The drop-on demand method is divided into a piezoelectric method by a piezoelectric element and a thermal method by heat. In the present invention, a drop-on-demand method in which the injection liquid is determined according to the control of the voltage applied to the piezoelectric element is applied. The waveform as shown in FIG. 3 should be supplied to the wire connected to the ground state of the piezoelectric element signal generator 32. The polarity of the drive signal may be monopolar or bipolar depending on the fluid used. Parameters: T _rise1 is the initial rise time, T _dwell is the holding time of the highest voltage (V1), T _fall is the transition time from the highest voltage to the lowest voltage, T _echo is the holding time of the lowest voltage (V2), and T _rise2 is Final rise time. The voltage V ₀ is generally 0 [V] and is set to V ₁ = −V ₂ , and the piezoelectric element has a capacitance equivalent to that of about 1 nanofarad. Physical properties such as the nozzle length of the injector and the viscosity of the injection fluid determine the timing.To minimize the driving voltage, the length of the rise and transition times from the highest voltage to the lowest voltage must be minimized. The time should be short. In addition, in the injector according to the present invention, when the volume of the dispersion droplet is to be increased, the rise time and the maximum voltage holding time are increased, or the diameter of the orifice is increased, and consequently, the voltages V1 and V2 are increased. In addition, an increase in the highest voltage and the lowest voltage leads to an increase in the injection amount.

Using this concept, we will briefly discuss how to operate the inkjet ejector according to the user's ejection needs.

Referring to the diagram of FIG. 3, the pressure control unit 50 of FIG. 1 forms a negative pressure inside the injection nozzle 21 at the initial rise time Tr ₁ to store the dispersion in the storage container 51. When the highest voltage generated during the holding time T _dwell of the highest voltage is applied from the piezoelectric element control signal generator 32 to the piezoelectric element 31, the negative pressure of the injection nozzle 21 becomes the highest and the injection nozzle is contracted to disperse the dispersion liquid. It flows toward this nozzle 21. At this time, the orifice 22 is formed in a concave up shape (meniscus) like a crescent. As the sign of the voltage is changed at the transition time T _fall from the highest voltage to the lowest voltage, the inner part of the piezoelectric element 31 is contracted, and the dispersion liquid flows into the injection nozzle 21 to enlarge the dispersion volume, and the dispersion liquid to the orifice 22. Drops form. During the holding time (T _echo ) of the lowest voltage (V2) The inside contraction of the piezoelectric element 31 is maximized, and the dispersion droplet is ejected. In this way, the size of the dispersion droplet can be adjusted, the drop of the dispersion droplet is made slowly, the orifice is unevenly wet, the cleaning of the spray nozzle is not clean and the spraying does not occur in a straight line. By observing the shape of the droplet sprayed through the portion 40, it is possible to readjust the shape and the spray amount of the droplet.

Hereinafter, a method of spraying an inkjet spraying biocompatible material according to a first embodiment of the present invention will be described in detail.

4 shows a sequential process for preparing a biocompatible material according to one embodiment of the invention.

First, as the substrate preparation step (S100), a metal flat substrate is prepared in the first embodiment. Various kinds of metals such as stainless steel, cobalt-chromium alloy, titanium alloy and the like are mainly used as the base material for producing the biomaterial, but other materials such as a polymer material may also be used as the substrate. In the present invention, Ti-4Al-4V alloy is used as the substrate.

Next, as the dispersion preparation step (S200), there are a variety of biocompatible materials sprayed in the form of a thin film on the surface of the substrate, but in this embodiment, hydroxide apatite (Hydroxy apatite) is used. The apatite hydroxide particles need to be small enough, such as several micrometers, to allow free flow of the dispersion through an inkjet jetting device, especially in an ejecting nozzle, typically in the range of 10 microns to 50 microns in diameter. Particle size also affects the dispersion stability of the dispersion, which is important throughout the life of the dispersion. Brown motion of fine particles helps to prevent the particles from settling, and it is also desirable to use small particles for maximum adhesive strength.

Therefore, in order to refine the apatite hydroxide particles to a size of about several micrometers, in the pulverizing step (S201), a collision pulverization method is used in which the particles are mechanically impacted and pulverized. Media mills, attritors, hammer mills, homogenizers, jet mills and the like may also be used to impinge the particles. In a preferred embodiment of the present invention, a dispersion in which the pulverized apatite particles and distilled water are mixed at an appropriate ratio is subsequently processed by a ball mill or digi mill method to disperse even dispersion in the dispersion of the apatite hydroxide particles. I went through step S202

In the third step for preparing the dispersion, as many impurities may be contained in the ground particles as described in International Patent Publication No. WO92 / 05745, the impurities should be excluded as much as possible because they may degrade the biocompatibility of the implant's chemical properties. The requirement to do is well known in the art. Therefore, in the filtering step (S203) through the physical filtering to remove foreign substances and excess particles and to make the particle size uniform.

As shown in FIG. 5, it can be seen that the particle size before filtering is uniform but the particle size after filtering is uniform as about 1 μm. If a uniform apatite hydroxide having a size of several micrometers can be obtained, the filtering method is not limited here.

It is necessary to adjust the ratio of the uniform size of apatite hydroxide to distilled water to an appropriate concentration of about 5 to 10%. This is a value in consideration of the adhesive strength to the metal substrate of the dispersion.

In addition, the inkjet spraying step (S300) stores the biocompatible material dispersion of the fine structure prepared in the dispersion preparation step (S200) in the storage container 51 (S301), and adjusts the air pressure so that the biocompatible material dispersion does not flow down and (S302), the voltage and waveform of the piezoelectric element control signal generator 32 are set (S303). However, the piezoelectric element is configured to obtain a shape desired by the user according to the shape of the dispersion droplet as shown in FIG. 6 according to the shape observed through the observation unit 40 including the observation signal generator 41 and the observation signal receiver 42. The voltage waveform of the control signal generator 10 may be reset. In general, the LED strobe device 41 may be used as the observation signal generator in the observation unit 40, and the CCD camera 40 may be used as the observation signal receiver. When the frequency of light emitted from the LED strobe device 41 and the spraying speed of the dispersion droplets sprayed from the spray nozzle 21 are synchronized, the droplets of the sprayed dispersion are stopped as shown in FIG. 6. Can be observed. At this time, the specification of the CCD camera used was STC400 (380,000 pixels), and the lens used 12.5 zoom. In addition, the position of the substrate 61 injected to interlock with the stage driver 60 for driving the X-Y stage 100 may be moved left and right.

In the step S303 of setting the applied waveform of the piezoelectric element control signal generator 32, the time setting conditions for the applied waveform of one cycle are Tr ₁ = 5, T _dwell = 40, T _fall = 5, and T _echo = 40. , Tr ₂ = 5 [kPa]. It is preferable that the applied voltage is ± 25 [V], and the frequency is f = 2000 [Hz] including the rest time.

In the pressure setting step (S302), the pressure of the storage container 51 is set at 20 PSI, and the negative pressure in the nozzle 21 is set at 25 PSI, and the temperature and humidity are preferably set to room temperature and humidity.

Finally, in the curing step (S400), a curing system is constructed and preferably thermally cured at a temperature of about 600 ° C. When the temperature rises above about 900 ℃, the chemical properties of the hydroxide apatite (Hydroxy Apatite) changes because it is thermoset at a temperature of about 600 ℃ below this temperature. This thermal cure is intended to maintain the shape of the inkjet sprayed biocompatible material and to increase hardness.

In addition, in the second preferred embodiment of the present invention as shown in Fig. 7, an XY stage is formed by connecting the rear of the substantially cylindrical substrate 61 ', which is an implant part base material for making artificial teeth, with the rotary drive device 101. Place on (100). The rotation drive device 101 is preferably as little vibration as possible. In the generation or application waveform setting step (S303) of the piezoelectric element driving apparatus, the driving voltage waveform of the piezoelectric element is applied in synchronization with the rotational speed of the cylindrical substrate so that the injection speed of the injection liquid has a desirable interval for the drop of the injection liquid. The sprayed drops will then be arranged on the substrate at appropriate intervals. In addition, by adjusting the time point of the injection request, it is possible to inject the injection liquid only in a specific area portion of the cylindrical substrate, for example, in the axial direction, or even in a specific area portion in the circumferential direction, even if located at the same position in the axial direction. This can be very useful. For example, when implanting the root of an artificial tooth, the jawbone should be coated with hydroxide apatite, and the jawbone and non-closed area should be coated with collagen closer to the skin tissue. I can think of it. That is, different biocompatible materials may be coated according to the position of one object. In addition, a pattern can be formed to occlude the shape of the injured tooth so that the full function of the injured tooth can be restored when the tooth decay or the tooth is damaged by the trauma. This is because the patterning characteristic, which is inherent in the inkjet injection method, can be utilized.

The other dispersion preparation step, injection step, observation step, resetting step of the piezoelectric drive device and pressure control unit, etc. are subjected to the same steps as in the first preferred embodiment.

In the detailed description of the present invention as described above, specific embodiments have been described, but various modifications are possible without departing from the scope of the present invention. Therefore, the scope of the present invention should not be limited to the described embodiments, but should be defined by the claims below and equivalents thereof.

The present invention relates to a biocompatible material injection system and an injection method using an inkjet injection system, the injection method according to the invention to prepare a substrate (S100), a dispersion preparation step (S200), and the dispersion liquid And an inkjet spraying step (S300) of inkjet-spraying onto the substrate, and a thermal curing step (S400) of thermally curing the inkjet-sprayed substrate onto which the dispersion is at a temperature of about 600 ° C. It is possible to build inkjet injection devices with hardware and software that go through the same process, spraying biomaterials such as apatite hydroxide or collagen, and conventional spraying, sputtering, electron beam deposition, laser deposition, plasma spraying and Compared to the sol-gel method, the process is simpler, and the initial investment cost for constructing the spraying system is low, and the nose of the biocompatible material is The effect of quick verification of the setting as desired by the user, the effect of adjusting the thickness of the biocompatible coating film as desired by the user, and the effect of applying a biocompatible material coating film of uniform thickness without aggregation And, in particular, the coating of a specific pattern that is difficult to implement in various methods, such as dental implants, to form an occlusal shape, and the upper and lower portions of the root can be coated with different biocompatible materials. It has an effect.

1 is a schematic diagram of an inkjet-injection apparatus for ejecting a biocompatible material in a drop on demand manner in accordance with the present invention;

2 is a circuit diagram of a pressure control unit of an inkjet injection device for controlling an initial pressure of a dispersion in which a biomaterial is dispersed in distilled water at a predetermined ratio;

3 is a voltage waveform diagram applied to a piezoelectric element from the piezoelectric element control signal generator according to the first embodiment;

4 is a flow chart of a method for spraying a biocompatible material using an inkjet spraying value,

Figure 5 is a comparison of the size of the biomaterial particles before and after filtering,

6 is a state during the injection and after the injection state of the biomaterial dispersion liquid observed from the observation unit,

7 is a schematic view of a second embodiment applied to a cylindrical substrate.

* Description of the symbols for the main parts of the drawings *

21: Nozzle 22: Orifice

31: piezoelectric element 32: piezoelectric element control signal generator

41: observation signal receiver 42: observation signal receiver

50: pressure control unit 51: dispersion liquid storage container

61, 61 ': Base material 100: X-Y stage

101: rotary drive device

Claims (7)

Inkjet-spraying the dispersion liquid to the distilled water of the pulverized biomaterial, liquid injection unit 20 consisting of a spray nozzle 21 and the orifice 22; and A piezoelectric element driving unit 30 disposed on an outer circumferential surface of the liquid injection unit and configured to be expanded and contracted according to the voltage waveform generated by the piezoelectric element control signal generator 32 to provide a piezoelectric driving force to the liquid injection unit; Observation unit 40 comprising an observation signal generator 41 and the observation signal receiver 42 to observe the shape of the dispersion droplet is injected through the injection nozzle 20 and the orifice 21; and To control the initial pressure of the dispersion in the storage container 51 storing the biomaterial dispersion Pressure control unit 50; and A stage driver 60 for setting the position of the substrate printed by the injector; and Maintain and shape the inkjet-sprayed biocompatible materials It includes; thermosetting unit, A biomaterial injection apparatus using an inkjet injection system, characterized in that the size of the biomaterial is controlled by filtering and the injection interval is controlled by a piezoelectric element control signal generator to spray the droplets of the dispersion. The method according to claim 1, The piezoelectric element signal generator 32 generates a pulse adjusted according to the injection shape observed by the observation signal receiver 42 to drive the piezoelectric element 31. Suitable material injectors. A substrate preparation step (S100) for preparing the substrate, Grinding step (S201) of grinding the biomaterial particles to a size of about 1 ㎛ or less by the impact grinding method, a dispersion step (S202) of dispersing a predetermined ratio of biomaterial particles in distilled water and foreign matter and excess particles in the dispersion Dispersion preparation step (S200) consisting of a filtering step (S203) to remove the; An inkjet spraying step (S300) of spraying the dispersion onto the substrate; Bio-material spraying method using an inkjet-jet system, characterized in that the dispersion comprises a thermal curing step (S400) for thermally curing the inkjet-jetted substrate at a temperature of about 600 ℃. The method according to claim 3, The inkjet injection step (S300) is a step (S301) of storing the biomaterial dispersion in the storage container 51, a pressure setting step (S302) for controlling the air pressure so that the biomaterial dispersion is not flowed from the nozzle, Setting the voltage waveform of the piezoelectric element signal generator 32 for generating the voltage waveform applied to the piezoelectric element (S303), and the shape of the biomaterial dispersant droplet sprayed through the injection nozzle 21 and the orifice 22. (S304), resetting the piezoelectric element control signal generator 32 according to the observed shape, and setting the position of the jetted substrate. Biocompatible material injection method using. The method of claim 4, wherein The thermal curing step (S400) is a biomaterial injection method using an inkjet injection system, characterized in that for curing the inkjet-jetted substrate in which the biomaterial dispersion is at about 600 ℃ The method of claim 4, wherein The application waveform setting step (S303) of the piezoelectric element control signal generator is to set the voltage waveform such that the interval between the injection speed of the dispersion liquid and the drop point of the dispersion liquid is synchronized with the rotational speed of the cylindrical substrate. A method for spraying a biocompatible material using an inkjet injection system. The method of claim 3, wherein The inkjet spraying step (S300) of spraying the dispersion onto the substrate is performed by spraying a different type of dispersion onto the substrate.