KR100451857B1 - Insect Repellent Paste - Google Patents
Insect Repellent Paste Download PDFInfo
- Publication number
- KR100451857B1 KR100451857B1 KR10-1998-0704695A KR19980704695A KR100451857B1 KR 100451857 B1 KR100451857 B1 KR 100451857B1 KR 19980704695 A KR19980704695 A KR 19980704695A KR 100451857 B1 KR100451857 B1 KR 100451857B1
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- KR
- South Korea
- Prior art keywords
- spp
- insect repellent
- paste
- weight
- hexahydropyrazino
- Prior art date
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- 239000000077 insect repellent Substances 0.000 title claims abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229920002261 Corn starch Polymers 0.000 claims abstract description 7
- 239000008120 corn starch Substances 0.000 claims abstract description 7
- 241000282472 Canis lupus familiaris Species 0.000 claims abstract description 4
- 241000283086 Equidae Species 0.000 claims abstract description 4
- 241000282326 Felis catus Species 0.000 claims abstract description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract description 10
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 125000003545 alkoxy group Chemical group 0.000 description 4
- 150000002431 hydrogen Chemical class 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- QRJZGVVKGFIGLI-UHFFFAOYSA-N 2-phenylguanidine Chemical compound NC(=N)NC1=CC=CC=C1 QRJZGVVKGFIGLI-UHFFFAOYSA-N 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 125000000753 cycloalkyl group Chemical group 0.000 description 3
- 125000000547 substituted alkyl group Chemical group 0.000 description 3
- OTPDWCMLUKMQNO-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrimidine Chemical compound C1NCC=CN1 OTPDWCMLUKMQNO-UHFFFAOYSA-N 0.000 description 2
- FSVJFNAIGNNGKK-UHFFFAOYSA-N 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one Chemical compound C1C(C2=CC=CC=C2CC2)N2C(=O)CN1C(=O)C1CCCCC1 FSVJFNAIGNNGKK-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241001137878 Moniezia Species 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000004414 alkyl thio group Chemical group 0.000 description 2
- 125000000304 alkynyl group Chemical group 0.000 description 2
- 150000001556 benzimidazoles Chemical class 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 229960002957 praziquantel Drugs 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- NVEPPWDVLBMNMB-SNAWJCMRSA-N 1-methyl-2-[(e)-2-(3-methylthiophen-2-yl)ethenyl]-5,6-dihydro-4h-pyrimidine Chemical compound CN1CCCN=C1\C=C\C1=C(C)C=CS1 NVEPPWDVLBMNMB-SNAWJCMRSA-N 0.000 description 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- WCBVUETZRWGIJQ-UHFFFAOYSA-N 2-[[(methoxycarbonylamino)-(2-nitro-5-propylsulfanylanilino)methylidene]amino]ethanesulfonic acid Chemical compound CCCSC1=CC=C([N+]([O-])=O)C(NC(NC(=O)OC)=NCCS(O)(=O)=O)=C1 WCBVUETZRWGIJQ-UHFFFAOYSA-N 0.000 description 1
- 241001626718 Anoplocephala Species 0.000 description 1
- 241000244186 Ascaris Species 0.000 description 1
- 241000253350 Capillaria Species 0.000 description 1
- 241000242722 Cestoda Species 0.000 description 1
- 241000986238 Crenosoma Species 0.000 description 1
- 241000522489 Cyathostomum Species 0.000 description 1
- 241000244152 Cyclophyllidea Species 0.000 description 1
- 241000577452 Dicrocoelium Species 0.000 description 1
- 241001389925 Digenea <Rhodophyta> Species 0.000 description 1
- 241001222688 Diorchis Species 0.000 description 1
- 241001137876 Diphyllobothrium Species 0.000 description 1
- 241000935794 Dipylidium Species 0.000 description 1
- 241000243990 Dirofilaria Species 0.000 description 1
- 235000003550 Dracunculus Nutrition 0.000 description 1
- 241000316827 Dracunculus <angiosperm> Species 0.000 description 1
- 241000244160 Echinococcus Species 0.000 description 1
- 241001439622 Elaphostrongylus Species 0.000 description 1
- 241000578375 Enoplida Species 0.000 description 1
- 241000498256 Enterobius Species 0.000 description 1
- HMCCXLBXIJMERM-UHFFFAOYSA-N Febantel Chemical compound C1=C(NC(NC(=O)OC)=NC(=O)OC)C(NC(=O)COC)=CC(SC=2C=CC=CC=2)=C1 HMCCXLBXIJMERM-UHFFFAOYSA-N 0.000 description 1
- 241000986243 Filaroides Species 0.000 description 1
- 241001636403 Gyalocephalus Species 0.000 description 1
- 241000315566 Habronema Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001464082 Hydatigera Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 241001547406 Hyostrongylus Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241001523499 Marshallagia Species 0.000 description 1
- 241000520690 Mesocestoides Species 0.000 description 1
- 241000556230 Metastrongylus Species 0.000 description 1
- 241000274183 Micromeria Species 0.000 description 1
- 241000986227 Muellerius Species 0.000 description 1
- YRWLZFXJFBZBEY-UHFFFAOYSA-N N-(6-butyl-1H-benzimidazol-2-yl)carbamic acid methyl ester Chemical compound CCCCC1=CC=C2N=C(NC(=O)OC)NC2=C1 YRWLZFXJFBZBEY-UHFFFAOYSA-N 0.000 description 1
- RAOCRURYZCVHMG-UHFFFAOYSA-N N-(6-propoxy-1H-benzimidazol-2-yl)carbamic acid methyl ester Chemical compound CCCOC1=CC=C2N=C(NC(=O)OC)NC2=C1 RAOCRURYZCVHMG-UHFFFAOYSA-N 0.000 description 1
- 241000244206 Nematoda Species 0.000 description 1
- 241000520254 Oesophagodontus Species 0.000 description 1
- 241000243981 Onchocerca Species 0.000 description 1
- 241000242716 Opisthorchis Species 0.000 description 1
- 241001221709 Oxyurida Species 0.000 description 1
- 241000904715 Oxyuris Species 0.000 description 1
- 241000545637 Parafilaroides Species 0.000 description 1
- 241000935974 Paralichthys dentatus Species 0.000 description 1
- 241001234663 Paranoplocephala Species 0.000 description 1
- 241000244187 Parascaris Species 0.000 description 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 1
- 241000522483 Poteriostomum Species 0.000 description 1
- 241001617421 Protostrongylus Species 0.000 description 1
- 241001137874 Pseudophyllidea Species 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 241001222586 Schistocephalus Species 0.000 description 1
- 241000242678 Schistosoma Species 0.000 description 1
- 235000005775 Setaria Nutrition 0.000 description 1
- 241000232088 Setaria <nematode> Species 0.000 description 1
- 241000203992 Spirometra Species 0.000 description 1
- 241000244042 Spirurida Species 0.000 description 1
- 241001617580 Stephanurus Species 0.000 description 1
- 241000244155 Taenia Species 0.000 description 1
- 241001477954 Thelazia Species 0.000 description 1
- 241000607216 Toxascaris Species 0.000 description 1
- 241000244031 Toxocara Species 0.000 description 1
- 241000242541 Trematoda Species 0.000 description 1
- 241000243774 Trichinella Species 0.000 description 1
- 241000530048 Triodontophorus Species 0.000 description 1
- 241000571986 Uncinaria Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- ZVIDWFUBDDXAJA-UHFFFAOYSA-N [2-(methoxycarbonylamino)-3h-benzimidazol-5-yl] 4-fluorobenzenesulfonate Chemical compound C1=C2NC(NC(=O)OC)=NC2=CC=C1OS(=O)(=O)C1=CC=C(F)C=C1 ZVIDWFUBDDXAJA-UHFFFAOYSA-N 0.000 description 1
- 229960002669 albendazole Drugs 0.000 description 1
- HXHWSAZORRCQMX-UHFFFAOYSA-N albendazole Chemical compound CCCSC1=CC=C2NC(NC(=O)OC)=NC2=C1 HXHWSAZORRCQMX-UHFFFAOYSA-N 0.000 description 1
- 230000002141 anti-parasite Effects 0.000 description 1
- 239000003096 antiparasitic agent Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- LGUDKOQUWIHXOV-UHFFFAOYSA-N epsiprantel Chemical compound C1C(C2=CC=CC=C2CCC2)N2C(=O)CN1C(=O)C1CCCCC1 LGUDKOQUWIHXOV-UHFFFAOYSA-N 0.000 description 1
- 229960005362 epsiprantel Drugs 0.000 description 1
- 229960005282 febantel Drugs 0.000 description 1
- 229960005473 fenbendazole Drugs 0.000 description 1
- HDDSHPAODJUKPD-UHFFFAOYSA-N fenbendazole Chemical compound C1=C2NC(NC(=O)OC)=NC2=CC=C1SC1=CC=CC=C1 HDDSHPAODJUKPD-UHFFFAOYSA-N 0.000 description 1
- 229960004500 flubendazole Drugs 0.000 description 1
- CPEUVMUXAHMANV-UHFFFAOYSA-N flubendazole Chemical compound C1=C2NC(NC(=O)OC)=NC2=CC=C1C(=O)C1=CC=C(F)C=C1 CPEUVMUXAHMANV-UHFFFAOYSA-N 0.000 description 1
- 125000004438 haloalkoxy group Chemical group 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 229950001484 luxabendazole Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229960003439 mebendazole Drugs 0.000 description 1
- OPXLLQIJSORQAM-UHFFFAOYSA-N mebendazole Chemical compound C=1C=C2NC(NC(=O)OC)=NC2=CC=1C(=O)C1=CC=CC=C1 OPXLLQIJSORQAM-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 231100001228 moderately toxic Toxicity 0.000 description 1
- 229960005121 morantel Drugs 0.000 description 1
- 229960000535 oxantel Drugs 0.000 description 1
- VRYKTHBAWRESFI-VOTSOKGWSA-N oxantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CC(O)=C1 VRYKTHBAWRESFI-VOTSOKGWSA-N 0.000 description 1
- 229960004454 oxfendazole Drugs 0.000 description 1
- BEZZFPOZAYTVHN-UHFFFAOYSA-N oxfendazole Chemical compound C=1C=C2NC(NC(=O)OC)=NC2=CC=1S(=O)C1=CC=CC=C1 BEZZFPOZAYTVHN-UHFFFAOYSA-N 0.000 description 1
- 229960002762 oxibendazole Drugs 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 229950007337 parbendazole Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 1
- -1 phenylthio, phenylsulfinyl Chemical group 0.000 description 1
- IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical compound O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 229960005134 pyrantel Drugs 0.000 description 1
- YSAUAVHXTIETRK-AATRIKPKSA-N pyrantel Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1 YSAUAVHXTIETRK-AATRIKPKSA-N 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000005326 tetrahydropyrimidines Chemical class 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Processing Of Solid Wastes (AREA)
- Fertilizers (AREA)
Abstract
본 발명은 활성 화합물에 더하여 옥수수 전분과 글리세롤을 함유하는 것을 특징으로 하는, 말, 개 및 고양이용 헥사히드로피라지노-유도체-기재 구충제 페이스트에 관한 것이다.The present invention relates to a hexahydropyrazino-derivative-based insect repellent paste for horses, dogs and cats, which contains corn starch and glycerol in addition to the active compound.
Description
본 발명은 말, 개 및 고양이용 헥사히드로피라지노-유도체-기재 구충제 페이스트(paste)에 관한 것이다.The present invention relates to hexahydropyrazino-derivative-based insect repellent pastes for horses, dogs and cats.
프라지퀀텔(praziquantel)을 함유한 페이스트는 EP-A 279 343 호에 기재되어 있다. 그러나, 이들 페이스트의 단점은 수분 함량이 크다는 것이다. 따라서 페이스트는 방부제로서 병원성 박테리아에 의한 공격으로부터 보호되어야 한다. 또한, 수용성이 부족한, 활성 화합물의 균질 혼합물은 자주 문제를 발생시킨다.Pastes containing praziquantel are described in EP-A 279 343. However, a disadvantage of these pastes is their high moisture content. The paste must therefore be protected from attack by pathogenic bacteria as a preservative. In addition, homogeneous mixtures of the active compounds, which lack water solubility, often cause problems.
본 발명은 활성 화합물에 더하여, 페이스트 형성을 위한 부형제로서 옥수수 전분과 글리세롤을 함유하는 것을 특징으로 하는, 말, 개 및 고양이용 헥사히드로피라지노-유도체-기재 구충제 페이스트에 관한 것이다.The present invention relates to a hexahydropyrazino-derivative-based insect repellent paste for horses, dogs and cats, in addition to the active compound, containing corn starch and glycerol as excipients for paste formation.
이러한 제제는 다음과 같은 장점이 있다:Such formulations have the following advantages:
1. 소수의 성분으로만 구성되고,1.consist of only a few components,
2. 저렴한 성분으로 구성되고,2. Consist of inexpensive ingredients,
3. 특정 방부제 없이도 처리되며,3. Can be processed without specific preservatives,
4. 제조하기 용이하다.4. Easy to manufacture
본 발명에 따른 바람직한 혼합물은 헥사히드로피라지노 유도체로서 프라지퀀텔과 엡시프란텔(epsiprantel)을 함유한 혼합물이다. 프라지퀀텔이 특히 바람직하다.Preferred mixtures according to the invention are mixtures containing praziquantel and epsiprantel as hexahydropyrazino derivatives. Fraziquantel is particularly preferred.
본 발명에 따른 제제는 활성 화합물을 5 내지 30 중량%, 바람직하게는 10 내지 20 중량%의 농도로 함유한다.The preparations according to the invention contain the active compound in a concentration of 5 to 30% by weight, preferably 10 to 20% by weight.
본 발명에 따른 제제는 옥수수 전분을 10 내지 30 중량%, 바람직하게는 15 내지 25 중량%의 농도로 함유한다.The preparations according to the invention contain corn starch at a concentration of 10 to 30% by weight, preferably 15 to 25% by weight.
본 발명에 따른 제제는 글리세롤을 40 내지 80 중량%, 바람직하게는 55 내지 75 중량%의 농도로 함유한다. 각 성분은 100 % 이하로 첨가된다. 글리세롤에 대한 옥수수 전분의 비율은 가공, 포장 및 사용이 용이한 제제를 얻는 방식으로 선택된다.The preparations according to the invention contain glycerol at a concentration of 40 to 80% by weight, preferably 55 to 75% by weight. Each component is added up to 100%. The ratio of corn starch to glycerol is chosen in such a way as to obtain a formulation that is easy to process, package and use.
헥사히드로피라지논에 더하여, 본 발명에 따른 제제는 또한 추가의 활성 화합물을 함유할 수 있다. 이들은 페닐구아니딘, 벤즈이미다졸 또는 테트라히드로피리미딘이다.In addition to hexahydropyrazinone, the preparations according to the invention may also contain further active compounds. These are phenylguanidine, benzimidazole or tetrahydropyrimidine.
페닐구아니딘으로서 다음 화학식 I의 화합물이 언급될 수 있다:As phenylguanidine, compounds of formula (I) may be mentioned:
[화학식 I][Formula I]
상기식에서In the above formula
R1은 수소, 임의로 치환된 알킬, 시클로알킬, 알콕시, 아릴 또는 아미노를 나타내며,R 1 represents hydrogen, optionally substituted alkyl, cycloalkyl, alkoxy, aryl or amino,
R2는 수소, 임의로 치환된 알킬, 시클로알킬, 알켄일, 알킨일, 아릴, 알콕시 또는 알켄옥시를 나타내며,R 2 represents hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, alkynyl, aryl, alkoxy or alkenoxy,
R3는 수소, 임의로 치환된 알킬, 시클로알킬, 알켄일, 알킨일 또는 아릴을 나타내며,R 3 represents hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, alkynyl or aryl,
R4는 알킬, 알콕시, 페녹시, 알킬티오, 페닐티오, 페닐설핀일, 페닐설폰일 또는 벤조일을 나타내며, 이들은 임의로 수소, 알콕시, 알킬티오, 할로게노알콕시 또는 할로게노알킬티오에 의해 치환된다.R 4 represents alkyl, alkoxy, phenoxy, alkylthio, phenylthio, phenylsulfinyl, phenylsulfonyl or benzoyl, which are optionally substituted by hydrogen, alkoxy, alkylthio, halogenoalkoxy or halogenoalkylthio.
벤즈이미다졸로서 다음 화학식 II의 화합물이 언급될 수 있다.As benzimidazoles, compounds of formula II may be mentioned.
[화학식 II][Formula II]
상기식에서In the above formula
R3 및 R4는 화학식 I의 화합물에 대해 제시된 의미를 가진다.R 3 and R 4 have the meanings given for the compounds of formula (I).
테트라히드로피리미딘으로서 다음 화학식 III의 화합물이 언급될 수 있다:As tetrahydropyrimidine, compounds of formula III may be mentioned:
[화학식 III][Formula III]
상기식에서In the above formula
R5는 수소 또는 알킬을 나타내며,R 5 represents hydrogen or alkyl,
R6는 임의로 치환된 페닐 또는 티엔일을 나타내고R 6 represents optionally substituted phenyl or thienyl
X는 -(CH2)2-3- 또는 -CH=CH-를 나타낸다.X represents-(CH 2 ) 2-3 -or -CH = CH-.
페닐구아니딘은 예를들어 페반텔(febantel)과 네토비민(netobimine)을 포함한다.Phenylguanidines include, for example, febantel and netobimine.
벤즈이미다졸은 예를들어, 페벤다졸(febendazole), 알벤다졸(albendazole), 옥시벤다졸(oxibendazole), 옥스펜다졸(oxfendazole), 메벤다졸(mebendazole), 플루벤다졸(flubendazole), 파르벤다졸(parbendazole) 및 룩사벤다졸(luxabendazole)이다.Benzimidazoles are for example febendazole, albendazole, oxibendazole, oxfendazole, mebendazole, flubendazole, Parbendazole and luxabendazole.
테트라히드로피리미딘은 예를들어 피란텔(pyrantel), 모란텔(morantel) 및 옥산텔(oxantel)을 포함한다.Tetrahydropyrimidines include, for example, pyrantel, morantel and oxantel.
본 발명에 따른 페이스트는 동물 사육 및 가축 사육시 말에 발생된 병원성 체내 기생층을 없애는데 적합하며; 이들은 온혈 동물에 대한 독성이 알맞다. 이들은 해충의 모든 발생 단계 또는 개별 발생 단계에 대해 효과적이며 내성이 있고 보통 과민성이 있는 종에 대해 효과적이다. 병원성 체내 기생충은 촌충, 흡충, 선충 및 구두충을 포함하며, 구체적으로는 다음과 같다:The paste according to the present invention is suitable for eliminating pathogenic physiological layers generated at the end of animal and livestock raising; They are moderately toxic to warm-blooded animals. They are effective against all developmental stages or individual developmental stages of pests, and against species that are resistant and usually hypersensitive. Pathogenic body parasites include tapeworms, fluke, nematodes and oral insects, specifically:
슈도필리데아(Pseudophyllidea) 목, 예를들어: 디필로보트리움 아종(Diphyllobothrium spp.), 스피로메트라 아종(Spirometra spp.), 쉬스토세팔루스 아종(Schistocephalus spp.)Pseudophyllidea, for example: Diphyllobothrium spp., Spirometra spp., Schistocephalus spp.
시클로필리데아(Cyclophyllidea) 목, 예를들어: 메소세스토이데스 아종(Mesocestoides spp.), 아노플로세팔라 아종(Anoplocephala spp.), 파라노플로세팔라 아종(Paranoplocephala spp.), 모니에지아 아종(Moniezia spp.), 타에니아 아종(Taenia spp.), 에치노코쿠스 아종(Echinococcus spp.), 히다티게라 아종(Hydatigera spp.), 디오르치스 아종(Diorchis spp.), 디필리디움 아종(Dipylidium spp.), 조이에욱시엘라 아종(Joyeuxiella spp.), 스피로메트라 아종(Spyrometra spp.)Cyclophyllidea tree, for example: Mesocestoides spp., Anoplocephala spp., Paranoplocephala spp., Moniezia subspecies (Moniezia spp.), Taenia spp., Echinococcus spp., Hydatigera spp., Diorchis spp., Diphyllium subspecies (Dipylidium spp.), Joyyeuxiella spp., Spyrometra spp.
디게네아(Digenea) 아강, 예를들어: 쉬스토소마 아종(Schistosoma spp.), 파스시올라 아종(Fasciola spp.), 디크로코엘리움 아종(Dicrocoelium spp.), 오피스토르치스 아종(Opisthorchis spp.)Digenea subclasses, for example: Schistosoma spp., Fasciola spp., Dicrocoelium spp., Opisthorchis spp. )
에노플리다(Enoplida) 목, 예를들어: 트리쿠리스 아종(Trichuris spp.), 카필라리아 아종(Capillaria spp.), 트리치넬라 아종(Trichinella spp.)Neck of Enoplida, e.g .: Tririchis spp., Capillaria spp., Trichinella spp.
라브디티아(Rhabditia) 목, 예를들어: 미크로네마 아종(Micronema spp.), 스트론길로이데스 아종(Strongyloides spp.)Rhabditia, for example: Micronema spp., Strongiloides spp.
스트론길리다(Strongylida) 목, 예를들어: 스트로닐루스 아종(Stronylus spp.), 트리오돈토포루스 아종(Triodontophorus spp.), 오에소파고돈투스 아종(Oesophagodontus spp.), 트리코네마 아종(Trichonema spp.), 기알로세팔루스 아종(Gyalocephalus spp.), 포테리오스토뭄 아종(Poteriostomum spp.), 시클리코시클루스 아종(Cyclicocyclus spp.), 스테파누루스 아종(Stephanurus spp.), 안시클로스토마 아종(Ancyclostoma spp.), 운시나리아 아종(Uncinaria spp.), 시아토스토뭄 아종(Cyathostomum spp.), 메타스트론길루스 아종(Metastrongylus spp.), 디크티오카울루스 아종(Dictyocaulus spp.), 무엘레리우스 아종(Muellerius spp.), 프로토스트론길루스 아종(Protostrongylus spp.), 엘라포스트론길루스 아종(Elaphostrongylus spp.), 파렐라포스트론길루스 아종(Parelaphostrongylus spp.), 크레노소마 아종(Crenosoma spp.), 파라크레노소마 아종(Paracrenosoma spp.), 필라로이데스 아종(Filaroides spp.), 파라필라로이데스 아종(Parafilaroides spp.), 마르샬라기아 아종(Marshallagia spp.), 효스트론길루스 아종(Hyostrongylus spp.), 올루라누스 아종(Ollulanus spp.), 크라테로스토뭄 아종(Craterostomum spp.), 시클리코돈토포루스 아종(Cyclicodontophorus spp.), 히알로세팔루스 아종(Hyalocephalus spp.), 시클린드로팔린스 아종(Cylindropharynx spp.), 카발로네마 아종(Caballonema spp.), 엘라에포루스 아종(Elaeophorus spp.), 디로필라리아 아종(Dirofilaria spp.), 온코세르카 아종(Onchocerca spp.), 세타리아 아종(Setaria spp.)Throngylida neck, for example: Stronylus spp., Triodontophorus spp., Oesophagodontus spp., Trichonema subspecies spp.), Gyalocephalus spp., Poteriostomum spp., Cyclicocyclus spp., Stephanurus spp., Ancyclostoma subspecies (Ancyclostoma spp.), Uncinaria spp., Cyathostomum spp., Metastrongylus spp., Dictiocaulus spp., Radish Muellerius spp., Protostrongylus spp., Elaphostrongylus spp., Parelaphotronylus spp., Crenosoma spp. .), Paracrerenosoma spp., Filaroides spp., Parafilaroides spp., Marshallagia spp., Hyostrongylus spp., Ololanus spp. ), Creterostomum spp., Cyclicodontophorus spp., Hyalocephalus spp., Cylindropharynx spp. Caballonema spp., Elaeophorus spp., Dirofilaria spp., Onchocerca spp., Setaria spp.
옥시우리다(Oxyurida) 목, 예를들어: 옥시우리스 아종(Oxyuris spp.), 엔테로비우스 아종(Enterobius spp.)Oxyurida, for example: Oxyuris spp., Enterobius spp.
아스카리디아(Ascaridia) 목, 예를들어: 아스카리스 아종(Ascaris spp.), 톡사스카리스 아종(Toxascaris spp.), 톡소카라 아종(Toxocara spp.), 파라스카리스 아종(Parascaris spp.), 프로브스트망그리아 아종(Probstmangria spp.)Ascariadia, for example: Ascaris spp., Toxascaris spp., Toxocara spp., Parascaris spp., Probes Stmangria subspecies (Probstmangria spp.)
스피루리다(Spirurida) 목, 예를들어: 텔라지아 아종(Thelazia spp.), 하브로네마 아종(Habronema spp.), 드라쉬아 아종(Draschia spp.), 드라쿤쿨루스 아종(Dracunculus spp.)Spirurida, for example: Thelazia spp., Habronema spp., Draschia spp., Dracunculus spp.
생성물은 예방학적으로 및 치료학적으로 모두 투여될 수 있다.The product can be administered both prophylactically and therapeutically.
본 발명에 따른 혼합물의 바람직한 사용 농도는 체중 kg 당 헥사히드로피라진 1 내지 300 mg, 바람직하게는 5 내지 50 mg이다.Preferred use concentrations of the mixtures according to the invention are 1 to 300 mg, preferably 5 to 50 mg of hexahydropyrazine per kg body weight.
추가의 구충활성 화합물을 kg 당 0.1 내지 20 mg, 바람직하게는 1 내지 10 mg, 특히 바람직하게는 약 5 mg의 적용 비율로 사용하는데 첨가할 수 있다.Further antiparasitic compounds may be added for use at an application rate of 0.1 to 20 mg, preferably 1 to 10 mg, particularly preferably about 5 mg per kg.
<실시예 1><Example 1>
경구 투여하거나 사료에 혼합하기 위한 페이스트Paste for Oral Administration or Mixing in Feed
조성:Furtherance:
프라지퀀텔 20.0 gFraziquantel 20.0 g
옥수수 전분 15.0 gCorn starch 15.0 g
글리세롤 65.0 gGlycerol 65.0 g
제조:Produce:
성분을 다같이 교반한다. 이로서 적합한 도포구에 채울 수 있는 페이스트를 얻는다.Stir the ingredients together. This obtains a paste that can be filled into a suitable applicator.
Claims (2)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19601263A DE19601263A1 (en) | 1996-01-16 | 1996-01-16 | Anthelmintic paste |
| DE19601263.5 | 1996-01-16 | ||
| PCT/EP1997/000006 WO1997025976A1 (en) | 1996-01-16 | 1997-01-03 | Anthelmintic paste |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR19990076602A KR19990076602A (en) | 1999-10-15 |
| KR100451857B1 true KR100451857B1 (en) | 2005-07-07 |
Family
ID=7782814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR10-1998-0704695A KR100451857B1 (en) | 1996-01-16 | 1997-01-03 | Insect Repellent Paste |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6025357A (en) |
| EP (1) | EP0877598B1 (en) |
| JP (1) | JP4143121B2 (en) |
| KR (1) | KR100451857B1 (en) |
| AT (1) | ATE201979T1 (en) |
| AU (1) | AU703567B2 (en) |
| BR (1) | BR9706976A (en) |
| CA (1) | CA2242972C (en) |
| DE (2) | DE19601263A1 (en) |
| DK (1) | DK0877598T3 (en) |
| ES (1) | ES2157551T3 (en) |
| HU (1) | HU227817B1 (en) |
| NZ (1) | NZ325850A (en) |
| PT (1) | PT877598E (en) |
| WO (1) | WO1997025976A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207179B1 (en) * | 2000-05-18 | 2001-03-27 | Phoenix Scientific, Inc. | Parasiticidal formulation for animals and a method of making this formulation |
| DE10358525A1 (en) | 2003-12-13 | 2005-07-07 | Bayer Healthcare Ag | Endoparasiticides Means for topical application |
| DE102005011779A1 (en) * | 2005-03-11 | 2006-09-14 | Bayer Healthcare Ag | Endoparasiticides means |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117156A (en) * | 1975-07-18 | 1978-09-26 | Ciba-Geigy Ag | Anthelmintic preparations |
| US4447414A (en) * | 1982-12-21 | 1984-05-08 | Cutter Laboratories, Inc. | Carnivore anthelmintics |
| US4675174A (en) * | 1985-08-16 | 1987-06-23 | Alza Corporation | Veterinary dispenser delivering beneficial agent by gas power generated in situ |
| DE3705227A1 (en) * | 1987-02-19 | 1988-09-01 | Bayer Ag | ANTHELMINTHIC ACTIVE COMBINATIONS |
| HU217811B (en) * | 1991-12-23 | 2000-04-28 | András Selmeczi | Process for producing gellike antiparasitical veterinary preparation containing methyl-5(6)-benzoyl-2-benzimidazole carbamate |
| AUPM969994A0 (en) * | 1994-11-28 | 1994-12-22 | Virbac S.A. | Equine anthelmintic formulations |
-
1996
- 1996-01-16 DE DE19601263A patent/DE19601263A1/en not_active Withdrawn
-
1997
- 1997-01-03 WO PCT/EP1997/000006 patent/WO1997025976A1/en active IP Right Grant
- 1997-01-03 HU HU9901023A patent/HU227817B1/en not_active IP Right Cessation
- 1997-01-03 DK DK97900555T patent/DK0877598T3/en active
- 1997-01-03 PT PT97900555T patent/PT877598E/en unknown
- 1997-01-03 AT AT97900555T patent/ATE201979T1/en active
- 1997-01-03 KR KR10-1998-0704695A patent/KR100451857B1/en not_active IP Right Cessation
- 1997-01-03 ES ES97900555T patent/ES2157551T3/en not_active Expired - Lifetime
- 1997-01-03 BR BR9706976-0A patent/BR9706976A/en not_active IP Right Cessation
- 1997-01-03 US US09/101,931 patent/US6025357A/en not_active Expired - Lifetime
- 1997-01-03 JP JP52563797A patent/JP4143121B2/en not_active Expired - Fee Related
- 1997-01-03 AU AU13093/97A patent/AU703567B2/en not_active Ceased
- 1997-01-03 DE DE59703789T patent/DE59703789D1/en not_active Expired - Lifetime
- 1997-01-03 CA CA002242972A patent/CA2242972C/en not_active Expired - Fee Related
- 1997-01-03 EP EP97900555A patent/EP0877598B1/en not_active Expired - Lifetime
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Also Published As
| Publication number | Publication date |
|---|---|
| ATE201979T1 (en) | 2001-06-15 |
| CA2242972A1 (en) | 1997-07-24 |
| JP2000503306A (en) | 2000-03-21 |
| CA2242972C (en) | 2005-03-15 |
| EP0877598A1 (en) | 1998-11-18 |
| DE19601263A1 (en) | 1997-07-17 |
| KR19990076602A (en) | 1999-10-15 |
| PT877598E (en) | 2001-11-30 |
| JP4143121B2 (en) | 2008-09-03 |
| HUP9901023A3 (en) | 1999-11-29 |
| BR9706976A (en) | 2000-01-04 |
| DE59703789D1 (en) | 2001-07-19 |
| DK0877598T3 (en) | 2001-07-23 |
| ES2157551T3 (en) | 2001-08-16 |
| WO1997025976A1 (en) | 1997-07-24 |
| HUP9901023A2 (en) | 1999-07-28 |
| EP0877598B1 (en) | 2001-06-13 |
| HU227817B1 (en) | 2012-03-28 |
| AU1309397A (en) | 1997-08-11 |
| AU703567B2 (en) | 1999-03-25 |
| NZ325850A (en) | 1999-02-25 |
| US6025357A (en) | 2000-02-15 |
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