KR100447278B1 - Personal care articles - Google Patents

Abstract

The present invention relates to a substantially dry disposable personal cleansing article comprising: a) a water insoluble substrate comprising: 1) a soft first layer exhibiting a total scratch cover value of less than about 17%; And 2) a peeling second layer placed near said first layer, said second layer exhibiting a total scratch cover value of about 17% to about 70%; And b) a cleansing component in the vicinity of the first and second layers, wherein the component comprises a foaming surfactant that is about 10% to about 1000% by weight of the water-insoluble substrate. Furthermore, the present invention relates to disposable personal cleansing articles suitable for conditioning and substantially dry. The articles have been found to be particularly useful for personal cleansing applications, ie for skin and hair.

Description

Personal Care Goods {PERSONAL CARE ARTICLES}

Personal care products, especially cleansing and conditioning products, have traditionally been marketed in various forms such as bar soaps, creams, lotions and gels. Typically, these products have been tried to satisfy many criteria that are acceptable to the consumer. The criteria include cleansing effects, skin feel, mildness in the skin, hair and eye mucous membranes and the volume of foam. An ideal personal cleanser should gently cleanse the skin or hair, cause little or no irritation, and should not be heavily accumulated or too dry on the skin or hair, even when used frequently.

It is also highly desirable to deliver the cleansing and conditioning efficacy in a disposable product. Disposable products are convenient because they obviate the need to transport or store cumbersome bottles, rods, jars, tubes and other forms of litter, including cleansing products and other products that can provide therapeutic or aesthetic benefits. Disposable products are also more hygienic alternatives to sponges, cleaning towels or other cleansing tools for multiple reuse, which may cause the tools to develop bacterial growth, unpleasant odors and other undesirable features related to repeated use. Because.

The articles of the present invention surprisingly provide cleansing and / or therapeutic efficacy effective to the skin and hair in a simple, inexpensive and hygienic manner. The present invention provides the convenience of not having to transport, store or use separate tools (such as cleaning towels or sponges), cleansers and / or therapeutic efficacy products. The article is convenient to use as it is in the form of a single disposable personal care article or multiple disposable articles useful for the application of therapeutic or aesthetic agonists as well as cleansing. Moreover, the article is suitable for use in or with another personal care tool designed for more multiple uses. In this case, the article of the invention is placed or attached in a separate personal care tool, such as a bath towel or washcloth, which is not usually disposable. In addition, the disposable article of the present invention may be removably attached to a handle or grip suitable for moving the article over a surface to be cleansed and / or treated therapeutically (eg, to be conditioned).

In a preferred embodiment, the articles of the invention are suitable for personal care use, but they also require car care, water vehicle care, which requires the application of cleansing and / or agonists such as waxes, conditioners, UV blockers, etc. to the surface or site. It may also be useful for a variety of other industries such as household care, animal care, animal care, and the like.

In a preferred embodiment of the invention, the article is suitable for personal care use and is useful for cleansing skin, hair and similar keratinous surfaces that require cleansing. The consumer wets the articles with water and rubs them onto the area to be cleansed. The article comprises a water insoluble substrate having a soft first layer exhibiting a total scratch cover value of less than about 17% and a peeling second layer exhibiting a total scratch cover value of from about 17% to about 70%, and a cleansing component. Or a therapeutically active ingredient comprising a therapeutic agonist that is about 10% to about 1000% by weight of the foaming surfactant or water-insoluble substrate, or both. Without being bound by theory, it is believed that substrates having two or more textures increase foaming, which in turn increases cleansing and peeling, and optimizes the delivery and deposition of therapeutic or aesthetic agents that may be included in the article. . It is also believed that multi-texturing of the article can appeal to a wider variety of users exhibiting a wide variety of skin types.

Summary of the Invention

The present invention relates to disposable personal care articles suitable for cleansing and substantially dry, comprising:

a) water insoluble substrate comprising:

1) a soft first layer exhibiting a total scratch cover value of less than about 17%; And

2) a peeling second layer placed in proximity of the first layer, wherein the second layer exhibits a total scratch cover value of about 17% to about 70%; And

b) a cleansing component in the vicinity of the first layer and the second layer, wherein the component comprises a foaming surfactant that is about 10% to about 1000% by weight of the water-insoluble substrate.

In another embodiment, the invention relates to a disposable personal care article suitable for cleansing and substantially dry comprising:

a) water insoluble substrate comprising:

1) a soft first layer exhibiting an average profilometer depth value of less than about 8; and

2) a peeling second layer placed in proximity of said first layer, said second layer exhibiting an average profilometer depth value of about 8 to about 80; And

b) a cleansing component in the vicinity of the first and second layers, wherein the component comprises a foaming surfactant that is from about 10% to about 1000% by weight of the water-insoluble substrate.

In another embodiment, the above-mentioned articles of the present invention include therapeutically effective ingredients in place of or in addition to cleansing ingredients.

The invention also relates to a method of cleansing and / or treating the skin and hair, comprising the following steps: a) wetting the article with water and b) contacting the wet article with the skin or hair.

All percentages and ratios used herein are by weight unless otherwise indicated, and all measurements are made at 25 ° C unless otherwise indicated. The invention is not only essential as described herein, but may comprise, consist of, or consist essentially of optional components and components.

Various embodiments and / or individual features are disclosed in the description of the invention. As will be apparent to one of ordinary skill in the art, any combination of the above embodiments and features is possible and can result in the desired performance of the invention.

All documents mentioned herein, including patents, patent applications, and publications, are incorporated herein by reference in their entirety in this disclosure.

Brief description of the drawings

1 shows an arrangement of equipment for measuring the total scratch cover value.

Detailed description of the invention

As used herein, "disposable" means, in general terms, an article that is discarded or discarded after a limited number of uses, preferably less than 25, more preferably less than about 10, and most preferably less than about 2 total uses. Used to mean.

As used herein, “substantially dry” means that an article of the invention has less than about 0.95 gms, preferably less than about 0.75 gms, even more preferably less than about 0.5 gms, even more preferably less than about 0.25 gms, More preferably less than about 0.15 gms, most preferably less than about 0.1 gms. Measurement of moisture retention is discussed later.

The personal care article of the present invention includes the following essential ingredients.

Water Insoluble Substrate

Articles of the invention include water-insoluble substrates further comprising two or more layers. Preferably, the substrate layer has a different texture where the first layer is softer on the skin of the consumer than the second layer, which is more peelable when used. However, both layers are preferably energizing and non-erosive to the skin. As used herein, "non-erosive" means that the layer is greater than about 15, preferably greater than about 30, more preferably greater than about 50, even more preferably measured by the Abrasiveness Value measurement described below. Means an erosion value of greater than about 70, most preferably greater than about 80. In all cases, however, each layer is defined as having both an inner and an outer surface, respectively. In both cases, the inner surface of the layer is towards the inner or innermost side of the article of the invention, and the outer surface of the layer is towards the outer or outermost side of the article. In general, the orientation of the article of the present invention is closer to the side of the article (i.e., the holding side) of which the layer is suitable for holding, the side of the article to which the remaining layer will contact the area to be cleansed and / or treated therapeutically, For example, it may be defined as being closer to the skin / position contact surface. However, both sides of the article are suitable for contact with the skin.

Without being bound by theory, water insoluble substrates enhance cleansing and / or therapeutic treatments. The substrate has a different texture on each layer or face such that the grabbing side of the article is a different texture than the skin / site contact face used at any time. The substrate can serve as an effective foaming and peeling tool. In physical contact with the skin or hair, the substrate significantly aids in cleansing and removing dirt, makeup, dead skin and other debris. However, in a preferred embodiment, the substrate is nonabrasive or nonerosive to the skin.

1st layer and 2nd layer

The water insoluble substrate of the present invention further includes a first layer exhibiting a total scratch cover value of less than about 17% and a second layer for exfoliation exhibiting a total scratch cover value of about 17% to about 70%. In addition, the water-insoluble substrate may be characterized as having a soft first layer exhibiting an average profilometer depth value of less than about 8 and a stripping second layer exhibiting an average profilometer depth value of about 8 to about 80. In both cases, the first layer is preferably loft and fluid permeable. As used herein, “loftable” means that the layer has a thickness of about 0.04 inches to about 2 inches at 5 gms / in ² and about 0.00005 g / cm 3 to about 0.1 g / cm 3, preferably about 0.001 g / cm 3 to about It has a density of 0.09 g / cm 3. Both layers are useful for introducing or retaining cleansing components in an article. Furthermore, the first and second layers are suitable for contact with the skin and hair. In the case of a two layer article, each layer or face of the article may serve different purposes given their different physical properties. As defined in the measurement methods described below, the first layer is intended to be softer, while the second layer is intended to exhibit more peelable properties. Thus, while the first layer may be desirable for users with more sensitive skin, the second layer (or cotton) may be desirable for users with skin that tends to be rougher and less sensitive to rubbing. The amount of scratches per square area of scratched sites by the water-insoluble substrate layer of the present invention is represented by the total scratch cover value measured using the following measurement method. Likewise, the average profilometer depth value measures the average depth of the scratch on the scratched surface by the water insoluble substrate layer. The value is measured using the measurement method detailed below.

This method involves rubbing the substrate along the test surface using a mechanical device and then examining the resulting scratch marks produced on the test surface using different analytical techniques.

How to measure total scratch cover and average profilometer depth

The first layer of the water insoluble substrate exhibits a total scratch cover value of less than about 17%, preferably less than about 15%, more preferably less than about 12%, and most preferably less than about 9%. Further, the first layer exhibits an average profilometer depth value of less than about 8, preferably less than about 7.75, more preferably less than about 7.5, and most preferably less than about 7.

The second layer of the water-insoluble substrate of the present invention is about 17% to about 70%, preferably about 17% to about 27%, more preferably about 17% to about 25%, most preferably about 17% to A total scratch cover value of about 23% is shown. In addition, the second layer is about 8 to about 80, preferably about 8 to about 50, more preferably about 8 to about 40, even more preferably about 8 to about 25, most preferably about 8 to about An average profilometer depth value of 15 is shown.

Since the different textures of the articles of the invention are an important feature of the articles, the difference in the total scratch cover values represented by the first and second layers is preferably from about 8 to about 37, more preferably from about 8 to about 27, Even more preferably about 8 to about 25, most preferably about 8 to about 21. Similarly, the difference in average profilometer depth values represented by the first and second layers is preferably about 2 to about 20, more preferably about 2 to about 15, even more preferably about 2 to about 12 And most preferably about 2 to about 8.

In order to measure the total scratch cover value and the average profilometer depth value, the following equipment is required.

Martindale Toothbrush Wear and Abrasion Tester: James H. Heal and Co. Ltd. 103, serial number 103-1386 / 2 upwards. Martindale 07-01-88. Texture Testing and QC Equipment. Foot area: 43 x 44 mm. 1 Kg weight.

2. Transparent Perspex strips 11 x 8 cm (eg ICI Acrylic) (for measuring total scratch cover)

3. Capped polystyrene strip 11 x 8 cm. Clean general purpose polystyrene layer on white High Impact polystyrene, for example EMA model supply name SS-20201L (for measuring average profilometer depth)

4. The substrate to be tested.

5. White Reflective Card (Kodak).

6. Medium Density Filter (Kodak).

7. ProScan 1000 Profilometer with Proscan 1000 Software

The plastic protective coating on the side to be scratched is removed and rinsed with ethanol (no tissue) to produce a perspex / polystyrene strip for scratches. Place the strip on a non-erosive surface and air dry the strip. Tape the edges and attach the perspex / polystyrene strip to the base of the Martindale Abrasion Tester. Place the perspex / polystyrene strip on the base of the Martindale abrasion tester, centering the strip longitudinally in the direction of travel, centrally under the path of the scrubbing device. Substrate samples are cut into 2.5 "x 2.5" pieces. With the machine direction of the substrate in the direction of movement, a piece of substrate is attached to the rub foot of the Martindale Abrasion Tester using double sided tape. With the screws provided, the scrubbing foot is fixed in the appliance. Arrange the 1 Kg weight on top of the scrub foot assembly to confirm that the scrub foot moves in only one direction (front and back). The entire Martindale Abrasion Tester is covered with a safety screen. Operate by setting the machine to perform 50 cycles per minute. (Frequency = 0.833 Hz). When the machine is stopped, the footer assembly is disassembled and the perspex / polystyrene strip is removed from the base of the machine. A label showing the substrate specimen used for the perspex / polystyrene styrene is made and stored in a plastic bag.

To determine the total scratch cover value, the perspex strip is analyzed using the following equipment.

1. Lightbox 'Landsco' low angle lightbox (UK supplier: Printing & Packaging Machinery Agency)

2. Hitachi KP-M1 Black and White CCD Camera

3. Framestore Synapse (UK from Synoptics Ltd)

4. Image processing software (eg Semper Software, marketed by UK supplier Synoptics Ltd)

1 shows how the equipment is set up for strip analysis. Parallel light is given at a parallel angle on a specimen plane that is 60 degrees from horizontal. The CCD camera is at an angle of 30 ° from the sample plane side. At this angle, the unscratched sample surface light is reflected from the camera to produce a 'dark' image, while the scratch reflects some light toward the camera to produce a 'bright' image. Thus, the scratch surface visible is the surface oriented at a particular angle of the camera with respect to light. Thus, the deviation of the angle between the light, the specimen and the camera will cause a deviation in the actual appearance of the specimen. To minimize this deviation, a fixed sturdy lightbox is used as a reliable and repeatable image source (as opposed to guided by the fluid fiber-visual light) and the specimen mount is made of a rigid material.

For the measurement report, the observation conditions were set as follows:

15 microns per video resolution point

Observation range 7.68 x 7.68 mm

The image from the camera is digitized to 256 levels of gray by the framestore, representing an image matrix of 512 x 512 pixels. The total scratch cover value is calculated by measuring the total scratch area observed by the CCD camera and is expressed as a percentage of the viewing area. This is calculated from the scratch image, using the following procedure. Firstly, a correction is involved to observe the blank sample. It is used as a basic reference for unscratched materials. The blank reference value indicates 20-25 lux luminosity as measured by a camera lens (approximately 85 mm from the sample). A white reflecting card, known as a reflectance of about 90%, is observed. This is used as a white reference. White reference values indicate 80-85 lux luminosity as measured by a camera lens (approximately 85 mm from the sample). In order for the white level to be within the camera's brightness range, an additional medium density filter (0.2 OD) may be needed in front of the camera.

Subsequently, shading adjustment / gray level mapping is performed. A basic shading adjustment algorithm is applied to all images to compensate for any massive light deviations through the sample. This is due to a high-pass filter spanning 128 x 128 pixels. Remapping the gray level range to a logarithmic scale yields a more linear response to brightness. This is achieved by converting the gray level values of all pixels to P '(x, y) = ln (P (x, y)), where P' is the new image.

The image gray level is then evaluated. Each image is then re-evaluated with a dark / white reference, with a gray reference range of 0-255 so that the cancer reference mean maps to 0 and the white reference mean maps to 255.

In order to observe scratches on the strip caused by the substrate, the scratches are augmented by applying a highpass filter over the image using a 16 × 16 center (effectively an area of 240 × 240 microns). The threshold for scratch observation is then set for each image. This is defined as (image brightness average) * 90% + (image brightness SD). The threshold is carefully biased by the overall brightness of the image, so that more scratches are where the image is brighter. Forms less than 4 points in the area are excluded. The circular form is excluded (to eliminate some dust effects). The circularity of the particles is defined as (4 * [pi] * area) / (circumference ² ) and has a value of 0 to 1 (1 = complete circle). Particles with values greater than 0.6 are excluded. Then all remaining shapes are defined as visible scratches. The total scratch area is then calculated and expressed as a percentage of the observation area. This value is the total scratch cover value.

To determine the average profilometer depth value, the polystyrene strips are analyzed. The analysis involves tapening a scratched polystyrene strip (scratch face up) onto the profilometer, across the center of cells 1, 1. Make sure the plate is flat. The scan is started after setting the scan coefficient to the following coefficient.

Start position 002.0 mm x 003.0 mm

Step 0.010 mm x 0.010 mm

Distance (step) 1000 x 1000 μm

x-y resolution 10 ㎛

Calculate and record the roughness values Ra, Rz and Rmax with ProScan software

Where Ra is the arithmetic mean deviation of the evaluated profile. The arithmetic mean of the absolute longitudinal Z (x) values is within the sample length.

Ra = 1 / l ∫│Z (x) │dx (integral to length 0 → 1)

Rz: For each profile, divide the evaluation length into 5 equal parts and calculate the value of the sum of the largest profile peak height and the largest profile valley depth within each minute. Rz is an average of the five values.

Rmax: Sum of the largest profile peak height and the largest profile valley depth within the evaluation length.

NB: A scan of 1 cm x 1 cm uses 1000 profiles. The Ra, Rz and Rmax values for each profile are averaged to give a result).

Rz represents the average profilometer depth value of the substrate tested.

Erosion measurement

Erosion values represent the "non-abrasive" properties of the first and second layers of the article. The layer of the present invention is weakly peelable but not rough to the skin. Thus, erosion value measurements involve rubbing a substrate along a test surface using a mechanical device and then examining the resulting scratch marks produced on the test surface using different analytical techniques.

The assay requires the following equipment:

1. Martindale Toothbrush Wear and Erosion Tester: James H. Heal and Co. Ltd. 103, serial number 103-1386 / 2 upwards. Martindale 07-01-88. Texture Testing and QC Equipment. Foot area: 43 x 44 mm. 1 Kg weight.

2. 11 x 8 cm capped polystyrene strips. Clean general purpose polystyrene layer on white high impact polystyrene, for example EMA model supply name SS-20201L.

3. The substrate to be tested.

4. Glossmeters, eg Sheen Tri-Microgloss 20-60-85

The plastic protective coating on the side to be scratched is removed and rinsed with ethanol (no tissue) to prepare a polystyrene strip for scratches. Place the strip on a non-erosive surface and air dry the strip. Tape the edges and attach the polystyrene strip to the base of the Martindale Abrasion Tester. Position the polystyrene strips centered under the path of the scrubber with the length of the strip aligned with the direction of travel. Cut substrate specimens 2.5 "x 2.5". Using a double sided tape, the substrate specimen is attached to the rubbing foot of the Martindale Abrasion Tester, with the machine direction of the substrate in the direction of travel. With the screws provided, the scrubbing foot assembly is secured in the appliance. The 1 Kg weight is arranged on top of the scrub foot assembly to confirm that the scrub foot moves in only one direction (front and back). The entire Martindale Abrasion Tester is covered with a safety screen. Operate by setting the machine to perform 50 cycles per minute. (Frequency = 0.833 Hz). When the machine stops, the foot assembly is dismantled and the polystyrene strip is removed from the base of the machine. Labels representing the substrates used for the polystyrene styrene are stored and stored in plastic bags.

The strip is then analyzed. The strip is placed on a black construction paper background and five or more samples of the same substrate are analyzed to obtain a reproducible average. The glossmeter is placed perpendicular to the scratched side of the polystyrene strip (with the light perpendicular to the scratch) and centered. Select the 20 ° angle and measure the specimen to obtain the erosion value. As the erosion value decreases, the scratch or abrasiveness of the substrate increases.

Suitable materials for the first and second layers are selected from the group consisting of cellulosic nonwovens, nonloft nonwovens, sponges (ie, both natural and synthetic), molded films, batting, and combinations thereof do. Preferably, the layer is selected from the group consisting of cellulosic nonwovens, non-lofty nonwovens, molded films, batting, foams, sponges, reticulated foams, vacuum formed laminates, scrims, polymeric nets and combinations thereof. Substances are included. More preferably, the nonwoven layer comprises a material selected from the group consisting of cellulosic nonwovens, non-lofty nonwovens, molded films, batts, and combinations thereof. As used herein, "nonwoven" means that the layer does not include fibers that are woven into the fabric, but the layer need not include any fibers, such as molded films, sponges, foams, scrims, and the like. If the layer contains fibers, the fibers can be random (ie randomly arranged) or carded (ie, plugged to align primarily in one direction). Furthermore, the layer can be an additional layer, ie a composite material consisting of a blend of random and carded fiber plies.

In one embodiment, the polymeric net is arranged with the first layer through, for example, lamination, hydroentanglement, etc. by chemical methods such as heat or adhesives. This arrangement enhances the integrity of the entire article as well as the first layer, thereby increasing the substantivity of the article. Polymeric nets, herein referred to herein as "scream" materials, are described in detail in US Pat. No. 4,636,419, which is incorporated herein by reference. The scrim material may be formed directly during extrusion, or may be derived from the extruded film by stretching and splitting after fiberization or embossing. Scrims can be derived from polyolefins such as polyethylene or polypropylene, copolymers thereof, poly (butylene terephthalate), polyethylene terephthalate, nylon 6, nylon 66, and the like. Scrim materials are commercially available from various sources. Preferred scrim materials useful in the present invention are polypropylene scrims available from Conwed Plastics (Minneapolis, MN). Another preferred scrim material is polyethylene scrim, especially low density polyethylene, which is also commercially available from Conwed.

In another aspect of the present invention, Applicants have also discovered that by introducing a stream material into the first layer and then heating, a macroscopic three-dimensional feature is provided on the sheet. The macroscopic three-dimensionality has been shown to greatly enhance the cleansing performance of articles even when the basis weight of the sheet is essentially uniform. In particular, when the scrim / fiber composition is heated and then cooled, macroscopic three-dimensional properties are obtained. The process causes shrinking (in the X-Y axis) of the scrim and the sheets gain greater three-dimensionality because they are attached to the fibers. As used herein, the term "X-Y axis" refers to a face perpendicular to the thickness of a layer, ply, or article or component thereof. The X and Y axes usually correspond to the length and width of the sheet or sheet component, respectively. As used herein, the term "Z axis" refers to an axis perpendicular to the length and width of the cleansing sheet or components thereof of the present invention. The Z axis is usually the thickness of the sheet.

The degree of three-dimensionality added is controlled by the degree of shrinkage (eg, shrinkage by heating) of the scrim / cleansing formulation. The introduction of a scrim is particularly advantageous when the structure of the fiber is nonwoven, especially when the structure is hydrated. More details on suitable scrim material-containing nonwovens can be found in pending US applications 09 / 082,396 and 09 / 082,349, both filed on May 20, 1998 by Fereshtehkho et al. Hereby incorporated by reference.

The first and second layers can include various natural and synthetic fibers or materials. As used herein, "natural" means a substance or by-product of a plant, animal, or insect derived from a plant, animal, insect. Convenient substrate starting materials are usually fibrous nets comprising any conventional synthetic or natural fabric-length fibers or combinations thereof.

Non-limiting examples of natural materials useful in the present invention include, but are not limited to, silk fibers, keratin fibers and cellulosic fibers. Non-limiting examples of keratinous fibers include those selected from the group consisting of wool fibers, camel hair fibers and the like. Non-limiting examples of cellulosic fibers include those selected from the group consisting of wood pulp fibers, cotton fibers, hemp fibers, jute fibers, flax fibers, and combinations thereof. Cellulose fiber materials are preferred in the present invention.

Non-limiting examples of synthetic materials useful in the present invention include acetate fibers, acrylic fibers, cellulose ester fibers, modacrylic fibers, polyamide fibers, polyester fibers, polyolefin fibers, polyvinyl alcohol fibers, rayon fibers, polyethylene foams, polyurethanes Foams and combinations thereof. Examples of suitable synthetic materials include acrylics such as acryliclan, creslan and acrylonitrile based fibers, olon; Cellulose ester fibers such as cellulose acetate, arnell and asher; Polyamides such as nylon (eg, nylon 6, nylon 66, nylon 610, etc.); Polyesters such as fortrel, cordel and polyethylene terephthalate fibers, polybutylene terephthalate fibers, darkons; Polyolefins such as polypropylene, polyethylene; Polyvinyl acetate fibers; Polyurethane foams and combinations thereof. Such and other suitable fibers and nonwovens prepared therefrom are described in Riedel, "Nonwoven Bonding Methods and Materials", Nonwoven World (1987); The Encyclopedia Americana , vol. 11, pp. 147-153 and vol. 26, pp. 566-581 (1984); U.S. Patent No. 4,891,227, issued to Thaman et al. On January 2, 1990; And US Pat. No. 4,891,228, each of which is incorporated herein by reference in its entirety.

Preferred polyolefin fibers are fibers selected from the group consisting of polyethylene, polypropylene, polybutylene, polypentene and combinations and copolymers thereof. More preferred polyolefin fibers are fibers selected from the group consisting of polyethylene, polypropylene and combinations and copolymers thereof. Preferred polyester fibers are fibers selected from the group consisting of polyethylene terephthalate, polybutylene terephthalate, polycyclohexylenedimethylene terephthalate and combinations and copolymers thereof. More preferred polyester fibers are fibers selected from the group consisting of polyethylene terephthalate, polybutylene terephthalate and combinations and copolymers thereof. Most preferred synthetic fibers of the first and second layers include solid staple polyester fibers comprising polyethylene terephthalate homopolymers. Suitable synthetic materials include solid monocomponent (ie, chemically uniform) fibers, multiconstituent fibers (ie, one or more material types make up each fiber) and multicomponent fibers (ie, interlacing) Synthetic fibers comprising two or more different filament types, resulting in larger fibers, and combinations thereof. Preferred fibers include bicomponent fibers, multicomponent fibers, and combinations thereof. The bicomponent fibers may have a core-sheath arrangement or side by side arrangement. In all cases, the first and second layers may include a blend of fibers comprising the material described above, or a fiber itself comprising a blend of materials described above.

For core-sheet fibers, the core preferably comprises a material selected from the group consisting of polyolefins, polyesters and combinations thereof having a T _g of at least about 10 ° C. higher than the sheet material. In contrast, the sheet of bicomponent fibers preferably contains a polyolefin having a T _g of at least about 10 ° C. lower than the core material, a polyester polyolefin having a T _g at least about 10 ° C. lower than the core material and combinations thereof. The material selected is included.

In any case of side by side, core-sheet, or solid single component batches, the fibers of the first and second layers may exhibit a helical or spiral or corrugated arrangement, in particular bicomponent type fibers. to be.

Nylon fibers may be included in the preferred synthetic material for the first layer and / or the second layer. More preferred synthetic materials include nylon fibers formed into a scrim layer to which additional nylon fibers are bonded, such that the additional fibers form an arc on the scrim layer.

Nonwovens produced from natural materials are most often composed of meshes or sheets formed on a fine wire screen from a liquid suspension of fibers. See, CA Hampel et al., The Encyclopedia of Chemistry , 3rd ed., 1973, pp. 793-795 (1973); The Encyclopedia Americana , vol. 21, pp. 376-383 (1984); And GA Smook, Handbook of Pulp and Paper Technologies , Technical Association for the Pulp and Paper Industry (1986).

Natural material nonwovens useful in the present invention can be obtained from a wide variety of commercial sources. Non-limiting examples of suitable commercially available paper layers useful herein include Airtex, an embossed air-infused cellulosic layer with a basis weight of about 71 gsy, available from James River (Green Bay, WI). ; And emulsified air-infused cellulose based Walkisoft, having a basis weight of about 75 gsy, available from Walkisoft USA (Mount Holly, NC) Included.

Additional suitable nonwoven materials include US Pat. No. 4,447,294 to Osborn, May 8, 1984; 4,603,176 (June 29, 1986 to Bjorkquist); No. 4,981,557 (granted to Bjorkquist, Jan. 1, 1991); No. 5,085,736 to Feb. 4, 1992 to Bjorkquist; No. 5,138,002 to Bjorkquist, issued Aug. 8, 1992; No. 5,262,007 to Phan et al. Nov. 16, 1993; No. 5,264,082 to Phan et al. Nov. 23, 1993; No. 4,637,859 to Trokhan, Jan. 20, 1987; No. 4,529,480 to Trokhan, Jul. 16, 1985; No. 4,687,153 (August 18, 1987 to McNeil); 5,223,096 to Phan et al., June 29, 1993; and 5,679,222 to Rasch et al., October 21, 1997, but are not limited to, each of which is herein incorporated by reference in its entirety. It is cited in the literature.

Methods of making nonwovens are well known in the art. Generally, the nonwoven fabric is air adhering, water adhering, melt forming, splicing, spun bonding, or firstly cutting the fiber or filament from the long strand to the desired length, passing water or airflow, and then adhering to the fiber It may be produced by a carding process that deposits onto screens through which air or water passes. Regardless of its manufacturing method or composition, one or more of several types of bonding processes for securing the individual fibers together in the resulting layer are then performed to form a self-sustaining network. In the present invention, the nonwoven layer can be prepared by a variety of processes, including but not limited to air weaving, hydrated weaving, thermal bonding, and combinations of the above processes.

Nonwoven substrates produced from synthetic materials useful in the present invention can be obtained from various commercial sources. Non-limiting examples of suitable first layer and second layer materials useful herein include Veratec, Inc. Perforated Hydrated Textile Material HEF 40-047, comprising about 50% rayon and 50% polyester, available from Walpole, MA and having a basis weight of about 61 grams per square meter (gsm). ; Veratec, Inc. Perforated hydration textile material HEF 140-102, comprising about 50% rayon and 50% polyester and having a basis weight of about 67 gsm, available from Walpole, Mass .; Veratec, Inc. Thermally bonded lattice pattern material Novonet, comprising about 100% polypropylene and having a basis weight of about 60 gsm, available from Walpole, Mass. 149-616; Veratec, Inc. Thermobonded grating pattern material Novonet, comprising about 69% rayon, about 25% polypropylene, and about 6% cotton and having a basis weight of about 90 gsm, available from Walpole, Mass. 149-801; Veratec, Inc. Thermobonded grating pattern material Novonet, comprising about 69% rayon, about 25% polypropylene, and about 6% cotton and having a basis weight of about 120 gsm, available from Walpole, Mass. 149-191; Veratec, Inc. Knotty perforated hydration textile material HEF Nubtex, comprising about 100% polyester, commercially available from Walpole, Mass., And having a basis weight of about 84 gsm. 149-801; Dry molded perforated material Keybak, comprising about 75% rayon, about 25% acrylic fiber, and having a basis weight of about 51 gsm, available from Chicopee (New Brunswick, NJ). 951V; Perforated material Keybak, commercially available from Chicopee (New Brunswick, NJ), comprising about 75% rayon, about 25% polyester, and having a basis weight of about 47 gsm. 1368; Perforated Hydrated Textile Material Duralace, comprising about 100% rayon and having a basis weight of about 48 gsm to about 138 gsm, available from Chicopee (New Brunswick, NJ). 1236; Perforated Hydrated Textile Material Duralace, comprising about 100% polyester and having a basis weight of about 48 gsm to about 138 gsm, available from Chicopee (New Brunswick, NJ). 5904; From about 60 gsm to about 90 gsm, including about 70% rayon, about 30% polyester and optionally up to about 5% w / w latex binder (based on Acrylate or EVA), available from Chicopee (New Brunswick, NJ) Carded hydration material (8 x 6 per inch, 3 x 2 per cm) with a basis weight of Chicopee 5763; From about 36 gsm to about 84 gsm, comprising a fiber composition of 50% rayon to 50% rayon or 100% rayon or 100% rayon to 0% polyester, available from Chicopee (New Brunswick, NJ) Carded Hydrating Textile Material, Weight-Based, Chicopee 9900 series (eg Chicopee 9931 (62 gsm, 50/50 rayon / polyester) and Chicopee 9950 (50 gsm, 50/50 rayon / polyester)); Dupont Chemical Corp. Hydrated textile material Sontara 8868, which comprises about 50% cellulose and about 50% polyester, and has a basis weight of about 72 gsm, commercially available. Preferred nonwoven matrix materials have a basis weight of 24 gsm to about 96 gsm, more preferably about 36 gsm to about 84 gsm, most preferably about 42 gsm to about 78 gsm.

The first and second layers can also be polymeric mesh sponges as described in published European patent application EP 702550A1 March 27, 1996, which is incorporated herein by reference in its entirety. Such polymeric mesh sponges include multiple layers of extruded tubular netting mesh made from nylon, or highly flexible polymers such as additive polymers of olefin monomers and polyamides of polycarboxylic acids.

The first and second layers may also include molded films and composite materials, ie multiple materials including molded films. Preferably, the molded film includes plastic that tends to be soft on the skin. Suitable soft plastic molded films include, but are not limited to, polyolefins such as low density polyethylene (LDPE). If the nonwoven layer comprises a plastic molded film, it is preferred that the nonwoven layer be perforated, for example macroperforated or microperforated, so that the layer is transparent to the fluid. In one embodiment, the nonwoven layer includes a plastic molded film that is only microperforated. The surface modification of the micropore, ie the male side, is preferably located on the inner surface of the second layer and preferably towards the inner side of the substrate, ie towards the cleansing component / therapeutic efficacy component. In certain embodiments involving perforations with petal-like edged surface modifications, regardless of theory, if the surface modifications of the perforations are directed towards the surfactant-containing cleansing component / therapeutic efficacy component, then the article is hand pressured. Added to fold the petal-like edges of the surface deformation inwards, creating numerous valves on the inner surface of the layer, which have the effect of discharging the cleansing component / therapeutic efficacy component contained within the article, extending the useful life of the article. It is believed that

In another embodiment, the first layer and / or the second layer include microperforated and macroperforated plastic molded films. In this embodiment, the layer is very suitable for contacting the site to be cleansed and / or treated therapeutically, giving a fabric-like feel of the microperforated film. Preferably, in this embodiment, the surface modification of the microperforation faces away from the surface modification of the macroporation on the layer (ie the first layer and / or the second layer). In this case, macroporation is believed to cause abundant foaming by maximizing the wetting / foaming of the entire article by the three-dimensional thickness formed from surface deformation under constant pressure and reduced pressure during use of the article.

In either case, the first layer and / or the second layer comprising the molded film is preferably at least about 100 perforation / cm 2, more preferably at least 500 perforation / cm 2, even more preferably at least about 1000 perforations on the substrate. / Cm 2 or more, most preferably about 1500 punch / cm 2 or more. In a more preferred embodiment of the present invention, from about 5 cm 3 / cm 2 -s to about 70 cm 3 / cm 2 -s, more preferably from about 10 cm 3 / cm 2 -s to about 50 cm 3 / cm 2 -s, most preferably about A first layer and / or a second layer having a water flux rate of 15 cm 3 / cm 2 -s to about 40 cm 3 / cm 2 -s is included.

Suitable molding films and composite film-containing composite materials useful for the first and / or second layers of the present invention include U.S. Patent No. 4,342,314, issued March 3, 1982 to Radel et al., Recently assigned co-pending US Serial No. 08 / 326,571 and PCT Application US95 / 07435 filed June 12, 1995 and published Jan. 11, 1996, and US Pat. No. 4,629,643 to Curro et al. But is not limited thereto, each of which is incorporated herein by reference in its entirety. In addition, the first layer and / or the second layer may be a molded film composite material comprising one or more molded films and one or more nonwovens in which the layers are vacuum formed. Suitable molded film composite materials include, but are not limited to, vacuum thin layered composite molded film materials formed by blending a carded polypropylene nonwoven having a basis weight of 30 gsm with a molded film.

In addition, the first layer and the second layer are preferably combined with each other to maintain the integrity of the article. The bond may be a spot bond (e.g., hot point bond), a continuous or discontinuous pattern connection (e.g., thinning, etc.), or a joining of the outer edge (or periphery) and / or discrete locations of the layer or It can consist of these combinations. The bond may also be arranged such that geometric shapes and patterns, such as diamonds, circles, squares, etc., are produced on the outer surface of the layer and the resulting article.

It is also contemplated that in articles of the present invention, the first layer and any additional layers can be surface modified to form a single composite layer having two sides of different textures. Thus, as a result, the water insoluble substrate can be described as including a single composite layer having a double texture face or surface.

In either case, it is more preferred that the bonding site present between the first and second layers does not exceed about 50% of the total surface area of the layer, preferably does not exceed about 15%, more preferably about 10% It is preferred that not exceeding, most preferably, not exceeding about 8%.

Each layer discussed herein includes at least two surfaces, an inner surface and an outer surface, each of which may have the same or different textures and degrees of erosion. Preferably, the article of the invention comprises a substrate, and thus a soft layer on the skin. However, different textures of the substrate can be obtained using different formulations of materials, using different manufacturing processes or by combining them. For example, dual textured water-insoluble substrates can be prepared to provide a personal care article with the advantages of having a more erosive face for exfoliation and a softer hygroscopic face for gentle cleansing and therapeutic treatment. In addition, individual layers of the substrate may be made in different colors to help the user distinguish the surface.

Furthermore, each layer of the article, as well as the article itself, can be manufactured in a wide variety of shapes and forms, including flat pads, thick pads, thin sheets, ball tools, irregular shaped tools. The exact size of the layer will depend on the desired use and characteristics of the article and can range from a surface area size of one square inch to several hundred square inches. Particularly convenient layers and article shapes include surface areas of about 5 in ² to about 200 in ² , preferably about 6 in ² to about 120 in ² , more preferably about 15 in ² to about 100 in ² and about 0.5 mm. Square, round, rectangular, hourglass, mitt type or ellipse shapes with a thickness of from about 50 mm, preferably from about 1 mm to about 25 mm, more preferably from about 2 mm to about 20 mm. However, it is not limited thereto.

Cleansing ingredients

Articles of the invention include a cleansing component further comprising one or more surfactants. The cleansing component is placed near the water insoluble substrate. In certain embodiments, the cleansing component is incorporated into the water insoluble substrate. In another embodiment, the cleansing component is deposited on one or both surfaces of the substrate. Articles of the invention include surfactants that are from about 10% to about 1,000%, preferably from about 50% to about 600%, more preferably from about 100% to about 250% by weight of the water-insoluble substrate. do. In addition, articles of the present invention preferably comprise at least about 1 gram of surfactant, based on the weight of the water-insoluble substrate. Thus, the cleansing component can be added to the substrate without the need for a drying process.

The surfactant of the cleansing component is preferably a foaming surfactant. As used herein, “foaming surfactant” means a surfactant that, when combined with water, mechanically shakes to produce a foam or foam. Since the increased foam is important to the consumer as an indicator of the cleansing effect, the surfactant is preferred. In certain embodiments, the surfactant or combination of surfactants is mild. As used herein, "warm" means that not only surfactants, but also articles of the present invention exhibit a skin softness comparable to synthetic bars based on mild alkyl glyceryl ether sulfonate (AGS) surfactants, ie synbars. it means. The method of determining the mildness or the irritation of the surfactant containing article is based on the skin barrier destruction test. In this test, the milder the surfactant, the less the skin barrier is destroyed. Skin barrier destruction is measured by the relative amount of radiolabeled (tritium labeled) water (3H-H ₂ O) that passes from the test solution through the skin epidermis and into the physiological buffer contained in the dialysate chamber. The tests are described in both TJ Franz, J. Invest. Dermatol. , 1975, 64, pp. 190-195; And US Pat. No. 4,673,525 to June 16, 1987 to Small et al. Other test methods for measuring surfactant mildness, which are well known to those skilled in the art, may also be used.

A wide variety of foaming surfactants are useful herein and are selected from the group consisting of anionic foaming surfactants, nonionic foaming surfactants, cationic foaming surfactants, zwitterionic foaming surfactants, and mixtures thereof. Things are included.

Anionic Foaming Surfactants

Non-limiting examples of anionic foaming surfactants useful in the compositions of the present invention are described in McCutcheon's, Detergents and Emulsifiers , North American edition (1986), Allured Publishing Corporation; McCutcheon's, Functional Materials , North American Edition (1992); And US Pat. No. 3,929,678, issued December 30, 1975 to Laughlin et al., Each of which is incorporated herein by reference in its entirety.

A wide variety of anionic foaming surfactants are potentially useful herein. Non-limiting examples of anionic foaming surfactants include alkyl and alkyl ether sulfates, sulfated monoglycerides, sulfonated olefins, alkyl aryl sulfonates, primary or secondary alkane sulfonates, alkyl sulfosuccinates, acyl taurates, Acyl isethionate, alkyl glyceryl ether sulfonate, sulfonated methyl ester, sulfonated fatty acid, alkyl phosphate, acyl glutamate, acyl sarcosinate, alkyl sulfoacetate, acylated peptide, alkyl ether carboxylate, acyl lactylate, Included are those selected from the group consisting of anionic fluorosurfactants and combinations thereof. Combinations of anionic surfactants can be used effectively in the present invention.

Anionic surfactants for use in cleansing components include alkyl and alkyl ether sulfates. The materials have the formula R 1 O—SO ₃ M and R 1 (CH ₂ H ₄ O) _x —O—SO ₃ M, respectively, wherein R 1 is saturated or unsaturated, branched or unsaturated from about 8 to about 24 carbon atoms. Branched alkyl groups, x is from 1 to 10, M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine). Alkyl sulfates are typically monohydric alcohols with sulfur trioxide ( Having about 8 to about 24 carbon atoms) or other known sulfated techniques. Alkyl ether sulfates are typically produced after condensation products of ethylene oxide and monohydric alcohols (having from about 8 to about 24 carbon atoms) and then sulfated. The alcohol may be derived from fats such as coconut oil or tallow, or may be synthetic. Specific examples of alkyl sulfates that can be used in the cleansing component are the sodium, ammonium, potassium, magnesium or TEA salts of lauryl or myristyl sulfate. Examples of alkyl ether sulfates that can be used include ammonium, sodium, magnesium or TEA laureth-3 sulfate.

Another suitable group of anionic surfactants are sulfated monoglycerides of the formula R 1 CO—O—CH ₂ —C (OH) H—CH ₂ —O—SO ₃ M, wherein R 1 is from about 8 to about 24 Saturated or unsaturated, branched or unbranched alkyl groups of carbon number, M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine). They are typically produced by reacting glycerin with fatty acids (having about 8 to about 24 carbon atoms) to form monoglycerides, which are then sulfated with sulfur trioxide. An example of sulfated monoglycerides is sodium cocomonoglyceride sulfate.

Other suitable anionic surfactants include olefin sulfonates of the formula R ₁ SO ₃ M (wherein R 1 is a monoolefin of about 12 to about 24 carbon atoms, M is a water soluble cation such as ammonium, sodium, potassium, magnesium, Triethanolamine, diethanolamine and monoethanolamine). The compound may be prepared by sulfonating an alpha olefin with uncomplexed sulfur trioxide and then neutralizing the acid reaction mixture under conditions such that all the sultone formed in the reaction is hydrolyzed with the corresponding hydroxyalksulfonate. Examples of sulfonated olefins are sodium C14 / C16 alpha olefin sulfonates.

Other suitable anionic surfactants are straight chain alkylbenzene sulfonates of the formula R 1 -C ₆ H ₄ -SO ₃ M, wherein R 1 is a saturated or unsaturated, branched or unbranched alkyl group of about 8 to about 24 carbon atoms. , M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine). They are formed by sulfonating linear alkyl benzene with sulfur trioxide. Examples of such anionic surfactants are sodium dodecylbenzene sulfonate.

Other anionic surfactants suitable for this cleansing component include primary or secondary alkane sulfonates of the formula R ₁ SO ₃ M, wherein R 1 is a saturated or unsaturated, branched or unbranched alkyl of about 8 to about 24 carbon atoms. Chain, M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine). These are usually formed by sulfonation of paraffins with sulfur dioxide in the presence of chlorine and ultraviolet light or by another known sulfonation method. Sulfonation may occur at the secondary or primary position of the alkyl chain. Examples of alkanesulfonates useful herein are alkali metal or ammonium C13-C17 paraffin sulfonates.

Other suitable anionic surfactants include alkyl sulfosuccinates, which include disodium N-octadecylsulfosuccinate; Diammonium lauryl sulfosuccinate; Tetrasodium N- (1,2-dicarboxyethyl) -N-octadecylsulfosuccinate; Diamyl ester of sodium sulfosuccinic acid; Dihexyl ester of sodium sulfosuccinic acid; And dioctyl esters of sodium sulfosuccinic acid.

Also useful are taurine based taurates, also known as 2-aminoethanesulfonic acid. Examples of taurates include those prepared by reacting N-alkyltaurine, such as dodecylamine with sodium isethionate, as described in US Pat. No. 2,658,072, which is incorporated by reference in its entirety. Other examples of taurine substrates include acyl taurine formed by reacting n-methyl taurine with fatty acids (having about 8 to about 24 carbon atoms).

Another group of anionic surfactants suitable for use in cleansing components is acyl isethionate. Acyl isethionates typically have the formula R 1 CO—O—CH ₂ CH ₂ SO ₃ M, wherein R 1 is a saturated or unsaturated, branched or unbranched alkyl group of about 10 to about 30 carbon atoms, and M is a cation ). They are typically formed by reacting fatty acids (having about 8 to about 30 carbon atoms) with alkali metal isethionates. Non-limiting examples of acyl isethionates include cocoyl isethionate, sodium cocoyl isethionate, sodium lauroyl isethionate and mixtures thereof.

Another suitable anionic surfactant is an alkylglyceryl ether sulfonate of the formula R1-OCH ₂ -C (OH) H-CH ₂ -SO ₃ M (wherein R1 is saturated from about 8 to about 24 carbon atoms). Or unsaturated, branched or unbranched alkyl groups, M being a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine). These are formed by reacting epichlorohydrin and sodium bisulfite with fatty alcohols (having from about 8 to about 24 carbon atoms) or by other known methods. One example is sodium cocoglyceryl ether sulfonate.

Other suitable anionic surfactants include sulfonated fatty acids of the formula R1-CH (SO ₄ ) -COOH and sulfonated methyl esters of the formula R1-CH (SO ₄ ) -CO-O-CH ₃ , wherein R1 Is a saturated or unsaturated, branched or unbranched alkyl group of about 8 to about 24 carbon atoms). These are formed by sulfonating fatty acids or alkyl methyl esters (having about 8 to about 24 carbon atoms) with sulfur trioxide or by other known sulfonation techniques. Examples include alpha sulfonated coconut fatty acids and lauryl methyl esters.

Other anionic materials include monoalkyl, dialkyl and trialkylphosphate salts formed by reacting phosphates, such as phosphorus pentoxide, with monovalent branched or unbranched alcohols of about 8 to about 24 carbon atoms. They can also be formed by other known phosphorylation methods. Examples of this group of surfactants are sodium mono- or dilaurylphosphate.

Other anionic materials include acyl glutamate corresponding to the formula R ₁ CO—N (COOH) —CH ₂ CH ₂ —CO ₂ M (wherein R 1 is saturated or unsaturated, branched or unpaired from about 8 to about 24 carbon atoms). Branched alkyl or alkenyl, and M is a water soluble cation). Non-limiting examples include sodium lauroyl glutamate and sodium cocoyl glutamate.

Other anionic materials include alkanoyl sarcosinates corresponding to the formula R1CON (CH ₃ ) -CH ₂ CH ₂ -CO ₂ M (wherein R1 is a saturated or unsaturated, branched chain of about 10 to about 20 carbon atoms). Or an unbranched alkyl group or alkenyl group, M is a water soluble cation). Non-limiting examples include sodium lauroyl sarcosinate, sodium cocoyl sarcosinate and ammonium lauroyl sarcosinate.

Other anionic materials include alkyl ether carboxylates corresponding to the formula R1- (OCH ₂ CH ₂ ) _x -OCH ₂ -CO ₂ M (wherein R1 is saturated or unsaturated of about 8 to about 24 carbon atoms). , Branched or unbranched alkyl group or alkenyl group, x is 1 to 10, M is a water soluble cation). Non-limiting examples include sodium laureth carboxylate.

Other anionic materials include acyl lactylates corresponding to the formula R 1 CO— [O—CH (CH ₃ ) —CO] _x —CO ₂ M (wherein R 1 is saturated or unsaturated from about 8 to about 24 carbon atoms). , Branched or unbranched alkyl or alkenyl group, x is 3 and M is a water soluble cation). Non-limiting examples include sodium cocoyl lactylate.

Other anionic materials include carboxylates, including but not limited to sodium lauroyl carboxylate, sodium cocoyl carboxylate and ammonium lauroyl carboxylate. Anionic fluorosurfactants may also be used.

Other anionic materials include natural soaps derived from saponification of vegetable and / or animal fats & oils, such as sodium laurate, sodium myristate, palmitate, stearate, tallowate, cocoate.

Any mating cation M can be used on the anionic surfactant. Preferably the counter cation is selected from the group consisting of sodium, potassium, ammonium, monoethanolamine, diethanolamine and triethanolamine. More preferably, the counter cation is ammonium.

Nonionic Foaming Surfactant

Non-limiting examples of nonionic foaming surfactants for use in the compositions of the present invention include those disclosed in McCutcheon's, Detergents and Emulsifiers , North American edition (1986), allured Publishing Corporation; And McCutcheon's, Functional Materials , North American edition (1992), both of which are incorporated herein by reference in their entirety.

Nonionic foaming surfactants useful herein include those selected from the group consisting of alkyl glucosides, alkyl polyglucosides, polyhydroxy fatty acid amides, alkoxylated fatty acid esters, sucrose esters, amine oxides and mixtures thereof.

Alkyl glucosides and alkyl polyglucosides are useful herein and are broadly defined as condensation products of long chain alcohols such as C8-C30 alcohols with sugars or starches or sugar polymers or starch polymers, ie glycosides or polyglycosides. Can be. The compound may be represented by the formula (S) _n- OR, wherein S is a sugar moiety such as glucose, fructose, mannose and galactose; n is an integer from about 1 to about 1000; R is C8- 30 alkyl group). Examples of long chain alcohols from which the alkyl group can be derived include decyl alcohol, cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol, oleyl alcohol and the like. Preferred examples of such surfactants include those in which S is a glucose moiety, R is a C8-20 alkyl group and n is an integer from about 1 to about 9. Examples of such commercially available surfactants include decyl polyglucoside (commercially available from Henkel as APG 325 CS) and lauryl polyglucoside (commercially available from Henkel as APG 600CS and 625 CS). Also useful are sucrose ester surfactants such as sucrose cocoate and sucrose laurate.

Other useful nonionic surfactants include polyhydroxy fatty acid amide surfactants, and more specific examples thereof include glucosamides corresponding to the formula:

Wherein R ¹ is H, C ₁ -C ₄ alkyl, 2-hydroxyethyl, 2-hydroxypropyl, preferably C ₁ -C ₄ alkyl, more preferably methyl or ethyl, most preferably Methyl; R ² is C ₅ -C ₃₁ alkyl or alkenyl, preferably C ₇ -C ₁₉ alkyl or alkenyl, more preferably C ₉ -C ₁₇ alkyl or alkenyl, most preferably C _11- C ₁₅ alkyl or alkenyl; Z is a polyhydroxyhydrocarbyl moiety having a straight chain hydrocarbyl chain having 3 or more hydroxyls directly connected to the chain or an alkoxylation thereof (preferably ethoxylated or propoxylated) Derivatives). Z is preferably a sugar moiety selected from the group consisting of glucose, fructose, maltose, lactose, galactose, mannose, xylose and mixtures thereof. Particularly preferred surfactants corresponding to this structure include coconut alkyl N-methyl glucoside amides (ie, the R ² CO- moiety is derived from coconut oil fatty acids). Methods for preparing compositions comprising polyhydroxy fatty acid amides are described, for example, in British Patent Application 809,060 (February 18, 1959), Thomas Hedley & Co., Ltd .; US Patent No. 2,965,576 to ER Wilson, Dec. 20, 1960; US Pat. No. 2,703,798, issued March 8, 1955 to AM Schwartz, and US Pat. No. 1,985,424, issued to Pigott, December 25, 1934, each of which is incorporated herein by reference in its entirety. .

Other examples of nonionic surfactants include amine oxides. The amine oxides correspond to the formula R ₁ R ₂ R ₃ N → O (wherein R ₁ is an alkyl, alkenyl or monohydroxy alkyl radical of about 8 to about 18 carbon atoms, 0 to about 10 ethylene oxide Moiety and 0 to about 1 glyceryl moiety, R ₂ and R _{3 having} from about 1 to about 3 carbon atoms and from 0 to about 1 hydroxy group, for example methyl, ethyl, propyl, hydroxyethyl or hydroxy Oxypropyl radicals, an arrow in the formula is a common indication of a semipolar bond). Examples of amine oxides suitable for use in the present invention include dimethyl-dodecylamine oxide, oleyldi (2-hydroxyethyl) amine oxide, dimethyloctylamine oxide, dimethyl-decylamine oxide, dimethyl tetradecyl Amine oxide, 3,6,9-trioxaheptadecyldiethylamine oxide, di (2-hydroxyethyl) -tetradecylamine oxide, 2-dodecoxyethyldimethylamine oxide, 3-dodecok Cy-2-hydroxypropyldi (3-hydroxypropyl) amine oxide, dimethylhexadecylamine oxide.

Non-limiting examples of preferred nonionic surfactants for use herein include C8-C14 glucose amide, C8-C14 alkyl polyglucoside, sucrose cocoate, sucrose laurate, laumine oxide, cocoamine oxide and their There are those selected from the group consisting of mixtures.

Cationic Foaming Surfactant

Cationic foaming surfactants are also useful in the articles of the present invention. Suitable cationic foaming surfactants include, but are not limited to, fatty amines, 2-fatty quaternary amines, 3-fatty quaternary amines, imidazolinium quaternary amines and combinations thereof. Suitable fatty amines include monoalkyl quaternary amines such as cetyltrimethylammonium bromide. Suitable quaternary amines include dialkylamidoethyl hydroxyethylmonium methosulfate. However, fatty amines are preferred. If the cationic foaming surfactant is the main foaming surfactant of the cleansing component, it is preferred to use foaming enhancers. In addition, it has been found that nonionic surfactants are particularly useful in combination with the cationic foaming surfactants.

Zwitterionic Foaming Surfactant

As used herein, the term “cationic foaming surfactant” is intended to also include zwitterionic surfactants well known to formulators in the art as a class of zwitterionic surfactants.

A wide variety of zwitterionic foaming surfactants can be used in the compositions of the present invention. Widely described as derivatives of aliphatic secondary and tertiary amines, preferably water-soluble groups which may be branched or straight chained with aliphatic radicals and in which the nitrogen is in a cationic state and one of the radicals is ionizable, for example carboxy, sulfonate Particularly useful are those which are, sulfates, phosphates or phosphonates.

Non-limiting examples of zwitterionic surfactants useful in the compositions of the present invention are described in McCutcheon's, Detergents and Emulsifiers , North American edition (1986), allured Publishing Corporation; And McCutcheon's, Functional Materials , North American Edition (1992), both of which are incorporated herein by reference in their entirety.

Non-limiting examples of zwitterionic or zwitterionic surfactants include those selected from the group consisting of betaine, sultine, hydroxysultine, alkyliminoacetates, iminodialkanoates, aminoalkanoates and mixtures thereof There are things.

Examples of betaines include higher alkyl betaines such as coco dimethyl carboxymethyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl alphacarboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, cetyl dimethyl betaine (from Lonza Corp. Lonzaine 16SP), lauryl bis- (2-hydroxyethyl) carboxymethyl betaine, oleyl dimethyl gamma-carboxypropyl betaine, lauryl bis- (2-hydroxypropyl) alpha-carboxyethyl betaine, Coco dimethyl sulfopropyl betaine, lauryl dimethyl sulfoethyl betaine, lauryl bis- (2-hydroxyethyl) sulfopropyl betaine, amidobetaine and amidosulfobetaine (herein RCONH (CH ₂ ) ₃ radicals Is attached to the nitrogen atom of betaine, oleyl betaine (available as zwitterionic Velvetex OLB-50 from Henkel) and cocamidopropyl betaine (available as Velvetex BK-35 and BA-35 from Henkel) Included.

Examples of sulfines and hydroxysultaines include substances such as cocamidopropyl hydroxysultine (available from Mira-Poulenc as Mirataine CBS).

Zwitterionic surfactants having the formula: are preferred for use herein:

Wherein R ¹ is about 9 to about 22 carbon atoms unsubstituted, saturated or unsaturated, straight or branched chain alkyl. R ¹ is preferably about 11 to about 18 carbon atoms, more preferably about 12 to about 18 carbon atoms, even more preferably about 14 to about 18 carbon atoms; m is an integer of 1 to about 3, more preferably about 2 to about 3, still more preferably about 3; n is 0 or 1 R ² and R ³ are independently selected from the group consisting of alkyl groups of 1 to about 3 carbon atoms, unsubstituted or monosubstituted with hydroxy, preferred R ² and R ³ are CH ₃ X is selected from the group consisting of CO ₂ , SO ₃ and SO ₄ ; R ⁴ is a group consisting of saturated or unsaturated, straight or branched chain alkyl of 1 to about 5 carbon atoms, unsubstituted or hydroxysubstituted; Is selected from). When X is CO ₂ , R ⁴ is preferably 1 or 3 carbon atoms, more preferably 1 carbon number. When X is SO ₃ or SO ₄ , R ⁴ is preferably from about 2 to about 4 carbon atoms, preferably 3 carbon atoms.

Examples of zwitterionic surfactants of the invention include the following compounds:

Cetyl dimethyl betaine (the material also has cetyl betaine under the CTFA name):

Cocamidopropyl Betaine:

Wherein R is from about 9 to about 13 carbon atoms

Cocamidopropyl Hydroxy Sultine:

*

Wherein R is from about 9 to about 13 carbon atoms.

Examples of other useful zwitterionic surfactants include the formulas RN [(CH ₂ ) _m CO ₂ M] ₂ and RNH (CH ₂ ) _m CO ₂ M (wherein m is 1-4 and R is C ₈ −). C ₂₂ alkyl or alkenyl, M is H, an alkali metal, alkaline earth metal ammonium or alkanol ammonium), an aminoalkanoate, an alkyliminoacetate and an iminodialkanoate. Also included are imidazolinium and ammonium derivatives. Specific examples of suitable zwitterionic surfactants include sodium 3-dodecyl-aminopropionate, sodium 3-dodecylaminopropane sulfonate, N-higher alkyl aspartic acids, such as US Pat. No. 2,438,091, which is incorporated herein in its entirety. Manufactured by the teachings of Citations; And products described in US Pat. No. 2,528,378, which is hereby incorporated by reference in its entirety, and sold under the trade name "Miranol". Other examples of useful zwitterionic surfactants include zwitterionic phosphates such as cocamidopropyl PG-dimonium chloride phosphate (available from Mona Corp. as Monaquat PTC). Ampoacetates such as disodium lauroampodiacetate, sodium lauroampoacetate and mixtures thereof are also useful.

Preferred foaming surfactants are selected from the group consisting of:

Ammonium lauroyl sarcosinate, sodium trideset sulfate, sodium lauroyl sarcosinate, ammonium laureth sulfate, sodium laureth sulfate, ammonium lauryl sulfate, sodium lauryl sulfate, ammonium cocoyl Isethionate, sodium cocoyl isethionate, sodium lauroyl isethionate, sodium cetyl sulfate, sodium monolauryl phosphate, sodium cocoglyceryl ether sulfonate, sodium C ₉ -C ₂₂ soap and combinations thereof Anionic foaming surfactants selected from the group consisting of; Nonionic foaming surfactants selected from the group consisting of laumine oxide, cocoamine oxide, decyl polyglucose, lauryl polyglucose, sucrose cocoate, C12-14 glucosamide, sucrose laurate and combinations thereof ; Cationic foaming surfactants selected from the group consisting of fatty amines, 2-fatty quaternary amines, 3-fatty quaternary amines, imidazolinium quaternary amines and combinations thereof; A zwitterionic foaming surfactant selected from the group consisting of disodium lauroampoacetate, sodium lauroampoacetate, cetyl dimethyl betaine, cocoamidopropyl betaine, cocoamidopropyl hydroxy sultaine and combinations thereof.

Therapeutic Efficacy Ingredients

In certain embodiments of the invention, the article comprises essentially therapeutically effective ingredients. The potent ingredient lies in the vicinity of the water insoluble substrate and is about 10% to about 1000% by weight of the water insoluble substrate, more preferably about 10% to about 500% by weight, most preferably about 10% by weight to About 250% by weight of therapeutic agonist is included. Preferably, the therapeutic agonist is selected from the group consisting of hydrophobic conditioning agents, hydrophilic conditioning agents, structured conditioning agents and combinations thereof.

Hydrophobic Conditioning Agent

Articles of the invention may include one or more hydrophobic conditioning agents useful for providing conditioning efficacy to the skin or hair during use of the article. The article of the invention preferably contains from about 0.5% to about 1,000%, more preferably from about 1% to about 200%, most preferably from about 10% to about 100% by weight of the water-insoluble substrate. Hydrophobic conditioning agents are included.

The hydrophobic conditioning agent may be selected from one or more hydrophobic conditioning agents such that the weighted arithmetic mean solubility parameter of the hydrophobic conditioning agent is 10.5 or less. Based on the mathematical definition of the solubility coefficient, for example, for hydrophobic conditioning agents comprising two or more compounds, the weight required, ie 10.5 or less, even if one of the compounds has an individual solubility coefficient of greater than 10.5 It is recognized that it is possible to achieve an arithmetic mean solubility coefficient.

Solubility coefficients are well known to formulation chemists in the art and are routinely used as guidelines for determining compatibility and solubility of materials in formulation processes.

The solubility coefficient δ of the chemical compound is defined as the square root of the aggregation energy density of the compound. Typically, the solubility coefficient for one compound is calculated from the tabulated values of the heat of evaporation and the addition group contribution to the molar volume of the component of that compound using the following formula:

(Wherein, Σ _i E _i = sum of contribution of evaporative heat _adder and Σ _i m _i = sum of contribution of molar volume _adder ).

Standard values for the evaporative heat and molar volume adder contributions of various atoms and atomic groups are described in Barton, AFM, Handbook of Solubility Parameters , CRC Publisher, Chapter 6, Table 3, pp. 64-66 (1985), the entirety of which is incorporated herein by reference. The solubility coefficient formula is described in Fedors, RF, "A Method for Estimating Both the Solubility Parameters and Molar Volumes of Liquids", Polymer Engineering and Science, vol. 14, no. 2, pp. 147-154 (February 1974), which is hereby incorporated by reference in its entirety.

The solubility coefficient follows the law of the mixture that the solubility coefficient of the substance mixture is given by the weight arithmetic mean (ie, weight average) of the solubility coefficients of each component of the mixture. See, Handbook of Chemistry and Physics , 57th Edition, CRC Publisher, p. C-726 (1976-1977).

Formulation chemists typically report and use solubility coefficients in units of (㎈ / cm 3) ^1/2 . In the Handbook of Solubility Parameters , the figures in the table for the contribution of the adder to the evaporative heat are reported in kJ / mol. However, the heat of evaporation values listed in the table are easily converted to dl / mol using the following well known formula:

1 J / mol = 0.239006 dl / mol and 1000 J = 1 kJ

See, Gordon, AJ et al., The Chemist's Companion , John Wiley & Sons, pp. 456-463 (1972).

The solubility coefficients for a wide variety of chemicals are also listed in the table. A table of solubility coefficients is given in the above mentioned Handbook of Solubility Parameters . See also, "Solubility Effects In Product, Package, Penetration, And Preservation", CD Vaughan, Cosmetics and Toiletries, vol. 103, 1988. 10., pp. 47-69.

Non-limiting examples of hydrophobic conditioning agents include mineral oil, petrolatum, lecithin, hydrogenated lecithin, lanolin, lanolin derivatives, C7-C40 branched chain hydrocarbons, C1-C30 alcohol esters of C1-C30 carboxylic acids, C2-C30 dicarboxyl C1-C30 alcohol ester of acid, monoglyceride of C1-C30 carboxylic acid, diglyceride of C1-C30 carboxylic acid, triglyceride of C1-C30 carboxylic acid, ethylene glycol monoester of C1-C30 carboxylic acid, C1 Ethylene glycol diesters of -C30 carboxylic acid, propylene glycol monoesters of C1-C30 carboxylic acid, propylene glycol diesters of C1-C30 carboxylic acid, C1-C30 carboxylic acid monoesters and polyesters of sugar, polydi Alkylsiloxanes, polydiarylsiloxanes, polyalkoxysiloxanes, cyclomethicones of 3 to 9 silicon waters, vegetable oils, hydrogenated vegetable oils, polypropylene glycol C4-C20 alkyl ethers, Di C8-C30 alkyl ethers and combinations thereof.

Mineral oils, also known as petrolatum liquids, are mixtures of liquid hydrocarbons obtained from petroleum. The Merck Index, 10th Edition, Entry 7048, p. 1033 (1983) and International Cosmetic Ingredient Dictionary, 5th Edition, vol. 1, p. 415-417 (1993).

Petrolatum, also known as petroleum jelly, is a colloidal system of non-chain solid hydrocarbons and high boiling liquid hydrocarbons, most of which are confined in micelles. The Merck Index, 10th Edition, Entry 7047, p. 1033 (1983); Schindler, Drug. Cosmet. Ind. , 89 , 36-37, 76, 78-80, 82 (1961); And International Cosmetic Ingredient Dictionary, 5th Edition, vol. 1, p. 537 (1993).

Lecithin is also useful as a hydrophobic conditioning agent. This is a naturally occurring mixture of diglycerides of certain fatty acids, linked to choline esters of phosphoric acid.

Straight and branched chain hydrocarbons of about 7 to about 40 carbon atoms are useful herein. Non-limiting examples of such hydrocarbon materials include dodecane, isododecane, squalane, cholesterol, hydrogenated polyisobutylene, docoic acid (ie, C ₂₂ hydrocarbons), hexadecane, isohexadecane (Presperse (South Plainfield, NJ)). Permethyl Hydrocarbons sold as 101A). Also useful are C7-C40 isoparaffins, which are C7-C40 side chain hydrocarbons. Polydecenes, branched liquid hydrocarbons, are also useful herein and are commercially available under the tradename Puresyn 100 from Mobile Chemical (Edison, NJ). And Puresyn 3000 Is commercially available.

Also useful are C1-C30 alcohol esters of C1-C30 carboxylic acids and C2-C30 dicarboxylic acids, including aromatic derivatives as well as straight and branched materials. Also esters such as monoglycerides of C1-C30 carboxylic acids, diglycerides of C1-C30 carboxylic acids, triglycerides of C1-C30 carboxylic acids, ethylene glycol monoesters of C1-C30 carboxylic acids, C1-C30 carboxyl Ethylene glycol diesters of acids, propylene glycol monoesters of C1-C30 carboxylic acids and propylene glycol diesters of C1-C30 carboxylic acids are useful. Straight chain, branched and aryl carboxylic acids are included here. Also useful are propoxylated and ethoxylated derivatives of these materials. Non-limiting examples include diisopropyl sebacate, diisopropyl adipate, isopropyl myristate, isopropyl palmitate, myristyl propionate, ethylene glycol distearate, 2-ethylhexyl palmitate, isodecyl neopentano Ate, di-2-ethylhexyl maleate, cetyl palmitate, myristyl myristate, stearyl stearate, cetyl stearate, behenyl behenate, dioctyl maleate, dioctyl sebacate, diisopropyl adipate, Cetyl octanoate, diisopropyl dilinoleate, caprylic / capric triglyceride, PEG-6 caprylic / capric triglyceride, PEG-8 caprylic / capric triglyceride and combinations thereof do.

Various C1-C30 monoesters and polyesters of sugars and related materials are also useful. The esters are derived from sugar or polyol moieties and one or more carboxylic acid moieties. Depending on its constituent acids and sugars, the esters may be in liquid or solid form at room temperature. Examples of liquid esters include: glucose tetraoleate, glucose tetraester of soybean oil fatty acid (unsaturated), mannose tetraester of mixed soybean oil fatty acid, galactose tetraester of oleic acid, arabinose tetraester of linoleic acid, xylose Tetralinoleate, galactose pentaoleate, sorbitol tetraoleate, sorbitol hexaester of unsaturated soybean oil fatty acid, xylitol pentaoleate, sucrose tetraoleate, sucrose pentaoleate, sucrose hexaoleate, sucrose heptaoleate, sucrose Octaoleate and mixtures thereof. Examples of solid esters include: sorbitol hexaester, palmitoleate and arachidate, in which the carboxylic acid ester moiety is in a 1: 2 molar ratio; Octaesters of raffinose with linoleate and behenate having a carboxylic acid ester moiety of 1: 3; Heptaester of sunflower seed oil fatty acid and lignocerate which is an esterified carboxylic acid moiety in a 3: 4 molar ratio; Octaesters of sucrose in which the esterified carboxylic acid moiety is a 2: 6 molar ratio of oleate and behenate; And octaesters of sucrose, wherein the esterified carboxylic acid moiety is laurate, linoleate and behenate in a 1: 3: 4 molar ratio. Preferred solid materials are sucrose polyesters having a degree of esterification of 7-8, fatty acid moieties of C18 mono- and / or di-unsaturated and behenic, with a molar ratio of unsaturated: behenic 1: 7 to 3: 5. . Particularly preferred solid sugar polyesters are octaesters of sucrose with about 7 behenic fatty acid moieties and about 1 oleic acid moiety in the molecule. Other materials include cottonseed or soybean oil fatty acid esters of sucrose. Ester materials include, but are not limited to, US Pat. No. 2,831,854, US Pat. No. 4,005,196 to Janacek, Jan. 25, 1977; US Patent No. 4,005,195 issued Jan. 25, 1977 to Jan. 25, US Patent No. 5,306, 516 issued to Letton et al., April 26, 1994; U.S. Patent No. 5,306,515, issued April 26, 1994 to Letton et al .; US Patent No. 5,305,514 to Letton et al. April 26, 1994; US Patent No. 4,797,300 issued Jan. 10, 1989 to Jan. Acek; US Patent No. 3,963,699 issued June 15, 1976 to Rizzi et al .; U.S. Patent No. 4,518,772 to Volpenhein, May 21, 1985; And US Pat. No. 4,517,360, issued May 21, 1985 to Volpenhein, each of which is incorporated herein by reference in its entirety.

Nonvolatile silicones such as polydialkylsiloxanes, polydiarylsiloxanes and polyalkoxysiloxanes are also useful oils. These silicones are disclosed in US Pat. No. 5,069,897 issued Dec. 3, 1991 to Orr, which is hereby incorporated by reference in its entirety. Polyalkylsiloxanes correspond to the formula R ₃ SiO [R ₂ SiO] _x SiR ₃ (wherein R is an alkyl group (preferably R is methyl or ethyl, more preferably methyl), x is the desired molecular weight Is an integer of about 500 or less selected to obtain). Commercially available polyalkylsiloxanes include polydimethylsiloxane, also known as dimethicone, including, but not limited to, Vicasil sold by General Electric Company Series and Dow Corning for sale from Dow Corning Corporation 200 series are included. Specific examples of polydimethylsiloxanes useful herein include Dow Corning having a viscosity of 10 centistokes and a boiling point above 200 ° C. Dow Corning with viscosities of 225 fluids, and 50, 350, and 12,500 centistokes, respectively, and boiling points above 200 ° C 200 fluids are included. Also useful are materials such as trimethylsiloxysilicate, which is a polymeric material corresponding to the formula [(CH ₂ ) ₃ SiO _1/2 ] _x [SiO ₂ ] _y , where x is an integer from about 1 to about 500 And y is an integer from about 1 to about 500). Commercially available trimethylsiloxysilicate is used in combination with dimethicone, Dow Corning Sold as 593 fluid. Dimethiconol, which is a hydroxy terminated dimethyl silicone, is also useful herein. The material may be represented by the formulas R ₃ SiO [R ₂ SiO] _x SiR ₂ OH and HOR ₂ SiO [R ₂ SiO] _x SiR ₂ OH, wherein R is an alkyl group (preferably R is methyl or ethyl More preferably methyl), x is an integer of about 500 or less selected to obtain the desired molecular weight). Commercial dimethiconols are typically mixed with dimethicone or cyclomethicone (eg, Dow Corning 1401, 1402, and 1403 fluid). Polyalkylaryl siloxanes are also useful herein, with polymethylphenyl siloxanes having a viscosity of about 15 to about 65 centistokes at 25 ° C. Such materials are commercially available, for example, as SF 1075 methylphenyl fluid (sold by General Electric Company) and 556 cosmetic grade phenyl trimethicone fluid (sold by Dow Corning Corporation). Alkylated silicones such as methyldecyl silicone and methyloctyl silicone are also useful herein and are commercially available from General Electric Company. Also useful are alkyl modified siloxanes such as alkyl methicones and alkyl dimethicones, wherein the alkyl chain is 10 to 50 carbon atoms. The siloxanes are sold under the trade names ABIL WAX 9810 (C ₂₄ -C ₂₈ alkyl methicone) (sold by Goldschmidt) and SF1632 (cetearyl methicone) (sold by General Electric Company).

Vegetable oils and hydrogenated vegetable oils are also useful herein. Examples of vegetable oils and hydrogenated vegetable oils include safflower oil, castor oil, coconut oil, cottonseed oil, menhaden oil, palm oil, palm oil, peanut oil, soybean oil, rapeseed oil, flaxseed oil, rice bran oil, pine oil, Sesame oil, sunflower seed oil, hydrogenated safflower oil, hydrogenated castor oil, hydrogenated coconut oil, hydrogenated cottonseed oil, hydrogenated menheiden oil, hydrogenated palm oil, hydrogenated palm oil, hydrogenated peanut oil, hydrogenated soybean oil, hydrogenated rapeseed oil, hydrogenated flaxseed oil, hydrogenated Rice bran oil, hydrogenated sesame oil, hydrogenated sunflower seed oil and mixtures thereof.

Also useful here are C4-C20 alkyl ethers of polypropylene glycol, C1-C20 carboxylic acid esters of polypropylene glycol, and di-C8-C30 alkyl ethers. Non-limiting examples of such materials include PPG-14 butyl ether, PPG-15 stearyl ether, dioctyl ether, dodecyl octyl ether, and mixtures thereof.

Hydrophobic chelating agents are also useful as hydrophobic conditioning agents. Suitable formulations are described in U.S. Patent Nos. 4,387,244, issued June 7, 1987 to Scanlon et al. And co-pending U.S. Patent Application Serial Nos. 09 / 258,747 and 09 / 259,485 to Schwartz et al. Application).

Hydrophilic Conditioning Agent

Articles of the invention may optionally include one or more hydrophilic conditioning agents. Non-limiting examples of hydrophilic conditioning agents include polyhydric alcohols, polypropylene glycols, polyethylene glycols, urea, pyrrolidone carboxylic acids, ethoxylated and / or propoxylated C3-C6 diols and triols, alpha-hydroxy C2-C6 Carboxylic acids, ethoxylated and / or propoxylated sugars, polyacrylic acid copolymers, sugars of up to about 12 carbon atoms, sugar alcohols of up to about 12 carbon atoms, and mixtures thereof. Specific examples of useful hydrophilic conditioning agents include urea; Guanidine; Glycolic acid and glycolate salts (eg, ammonium and quaternary alkyl ammonium); Lactic acid and lactate salts (eg, ammonium and quaternary alkyl ammonium); Sucrose, fructose, glucose, eruthrose, erythritol, sorbitol, mannitol, glycerol, hexanetriol, propylene glycol, butylene glycol, hexylene glycol, and the like; Polyethylene glycols such as PEG-2, PEG-3, PEG-30, PEG-50, polypropylene glycols such as PPG-9, PPG-12, PPG-15, PPG-17, PPG-20, PPG-26, PPG -30, PPG-34; Alkoxylated glucose; Hyaluronic acid; Cationic skin conditioning polymers (eg, quaternary ammonium polymers such as polyquaternium polymers); And materials such as mixtures thereof. In particular, glycerol is a preferred hydrophilic conditioning agent for the articles of the present invention. In addition, various forms of aloe vera (eg, aloe vera gel), chitosan and chitosan derivatives such as chitosan lactate, lactamide monoethanolamine; Acetamide monoethanolamine; And materials such as mixtures thereof are also useful. Propoxylated glycerol as described in propoxylated glycerol described in US Pat. No. 4,976,953, issued Dec. 11, 1990 to Orr et al., Is also useful and is incorporated herein by reference in its entirety.

Therapeutic efficacy ingredients can be prepared in various forms. In one embodiment of the invention, the therapeutically effective component is in the form of an emulsion. For example, oil-in-water, water-in-oil, water-in-water, and oil-in-water emulsions in silicone emulsions are useful herein. "Water" as used in connection with an emulsion may refer to water as well as water miscible materials such as water soluble or glycerin.

Preferred therapeutic efficacy ingredients include emulsions which further comprise an aqueous phase and an oil phase. As will be understood by one of ordinary skill in the art, a given component will mainly be distributed in the aqueous or oil phase depending on the water solubility / dispersibility of the therapeutic agonist in the component. In one embodiment, the oil phase includes one or more hydrophobic conditioning agents. In another embodiment, the aqueous phase includes one or more hydrophilic conditioning agents.

Therapeutic efficacy components of the present invention, in the form of emulsions, generally include an aqueous phase and an oil phase or lipid phase. Suitable oils or lipids may be derived from animals, plants or petroleum and may be natural or synthetic (ie artificial). Such oils are discussed above in the hydrophobic conditioning agent section. Suitable water phase components include the hydrophilic conditioning agents discussed above. Preferred emulsion forms include water-in-oil emulsions, water emulsions in silicones and other reverse phase emulsions. In addition, preferred emulsions also include hydrophilic conditioning agents, such as glycerin, to produce a glycerin in water emulsion.

The therapeutically effective component in the emulsion form will further comprise an emulsifier, preferably from about 1% to about 10%, more preferably from about 2% to about 5% by weight of the therapeutically effective component. Emulsifiers may be nonionic, anionic or cationic. Suitable emulsifiers are described, for example, in US Pat. No. 3,755,560 to Aug. 28, 1973 to Dickert et al .; U.S. Patent 4,421,769, issued December 20, 1983 to Dixon et al .; And McCutcheon's Detergents and Emulsifiers , North American Edition, p. 317-324 (1986). Therapeutic potency components in the emulsion form may also include antifoams to minimize foam formation when applied to the skin. Defoamers include high molecular weight silicone and other materials well known in the art for such uses.

The therapeutic efficacy component may also be in the form of a microemulsion. As used herein, "microemulsion" refers to a thermodynamically stable mixture of two immiscible solvents, one nonpolar and the other polar, stabilized by a surfactant which is an amphoteric molecule. Preferred microemulsions include water-in-oil microemulsions.

Structured conditioning agents

The therapeutically potent component may include structured conditioning agents. Suitable structured conditioning agents include, but are not limited to, vesicular structures such as ceramides, liposomes, and the like.

In another embodiment, the therapeutic agonist of the agonist is included in the coacervate forming composition. Preferably, coacervate forming compositions include cationic polymers, anionic surfactants, and dermatologically acceptable carriers for the polymers and surfactants. The cationic polymer is selected from the group consisting of quaternary ammonium polymers of natural backbone, quaternary ammonium polymers of synthetic backbone, zwitterionic type polymers of natural backbone, zwitterionic type polymers of synthetic backbone, and combinations thereof Can be.

More preferably, the cationic polymer is polyquaternium-4, polyquaternium-10, polyquaternium-24, PG-hydroxyethylcellulose alkyldimonium chloride, guar hydroxypropyltrimonium chloride, hydroxypropylguar Quaternary backbone quaternary ammonium polymers selected from the group consisting of hydroxypropyltrimonium chloride and combinations thereof; Polyquaternium-2, Polyquaternium-6, Polyquaternium-7, Polyquaternium-11, Polyquaternium-16, Polyquaternium-17, Polyquaternium-18, Polyquaternium-28, Polyquater Nium-32, polyquaternium-37, polyquaternium-43, polyquaternium-44, polyquaternium-46, polymethacrylamidopropyl trimonium chloride, acrylamidopropyl trimonium chloride / acrylamide copolymer And quaternary ammonium polymers of synthetic backbones selected from the group consisting of: Natural backbone zwitterionic polymers selected from the group consisting of chitosan, quaternized proteins, hydrolyzed proteins and combinations thereof; Polyquaternium-22, polyquaternium-39, polyquaternium-47, adipic acid / dimethylaminohydroxypropyl diethylenetriamine copolymer, polyvinylpyrrolidone / dimethylriaminoethyl methacrylate copolymer, Vinylcaprolactam / polyvinylpyrrolidone / dimethylaminoethyl methacrylate copolymer, nonylcaprolactam / polyvinylpyrrolidone / dimethylaminopropylmethacrylamide terpolymer, polyvinylpyrrolidone / dimethylaminopropylmethacryl Zwitterionic type polymers of synthetic backbones selected from the group consisting of amide copolymers, polyamines and combinations thereof; And combinations thereof. More preferably, the cationic polymer is a zwitterionic type polymer of the synthetic backbone. Even more preferably, the cationic polymer is a polyamine.

If the cationic polymer is a polyamine, the cationic polyamine polymer is preferably selected from the group consisting of polyethyleneimine, polyvinylamine, polypropyleneimine, polylysine and combinations thereof. Even more preferably, the cationic polyamine polymer is polyethyleneimine.

In certain embodiments where the cationic polymer is a polyamine, the polyamine can be modified to be hydrophobic or hydrophilic. In this case, the cationic polyamine polymer is selected from the group consisting of benzylated polyamines, ethoxylated polyamines, propoxylated polyamines, alkylated polyamines, amidated polyamines, esterified polyamines, and combinations thereof. The coacervate forming composition comprises a coacervate forming composition. Cationic polymers that are from about 0.01% to about 20% by weight, more preferably from about 0.05% to about 10% by weight, most preferably from about 0.1% to about 5% by weight.

Suitable anionic surfactants include those mentioned above in connection with the "cleansing component". Preferably, for coacervate forming compositions, the anionic surfactants are sarcosinates, glutamate, sodium alkyl sulfates, ammonium alkyl sulfates, sodium alkylate sulfates, ammonium alkylate sulfates, ammonium laureth-n-sulphate Pate, sodium laureth-n-sulfate, isethionate, glycerylether sulfonate, sulfosuccinate and combinations thereof. More preferably, the anionic surfactant is sodium lauroyl sarcosinate, monosodium lauroyl glutamate, sodium alkyl sulfate, ammonium alkyl sulfate, sodium alkylate sulfate, ammonium alkylate sulfate and combinations thereof It is selected from the group consisting of.

Suitable coacervate forming compositions are disclosed in co-pending US patent application Ser. No. 09 / 397,747, filed Sep. 16, 1999, respectively; 09 / 397,746 to Heinrich et al .; 09 / 397,712, filed by Schwartz et al .; 09 / 397,723 to Heinrich et al .; And 09 / 397,722 to Venkitaraman et al.

Alternatively, coacervate forming compositions may include anionic polymers, cationic surfactants, and dermatologically acceptable carriers for the polymers and surfactants. Anionic polymers consist of polyacrylic acid polymers, polyacrylamide polymers, copolymers of acrylic acid, acrylamides and other natural or synthetic polymers (e.g., polystyrenes, polybutenes, polyurethanes, etc.), natural derived rubbers, and combinations thereof It can be selected from the group. Suitable rubbers include alginates (eg propylene glycol alginate), pectin, chitosan (eg chitosan lactate) and modified rubbers (eg starch octenyl succinate) and combinations thereof. More preferably, the anionic polymer is selected from the group consisting of polyacrylic acid polymers, polyacrylamide polymers, pectin, chitosan and combinations thereof. Preferred articles of the invention include from about 0.01% to about 20% by weight, more preferably from about 0.05% to about 10% by weight, most preferably from about 0.1% to about 5% by weight of the coacervate forming composition Polymers are included. Suitable cationic surfactants include, but are not limited to, those discussed herein.

The therapeutically effective components of the article are not only conditioning agents, but also anti-acne agents, anti-wrinkle agents, antibacterial agents, antifungal agents, anti-inflammatory agents, local anesthetics, artificial tanning agents and accelerators, antiviral agents, enzymes, sunscreens, antioxidants, skin exfoliants and combinations thereof. These are suitable for providing a therapeutic or aesthetic effect on the skin or hair by depositing a variety of materials on the skin or hair surface, including but not limited to these.

It is to be understood that therapeutically potent ingredients may be included in the cleansing ingredients of the present invention or, conversely, may form one ingredient with components that are not distinguishable.

Multi-Item Implementation

The articles of the present invention may also be packaged separately or with additional articles suitable to provide a separate efficacy, for example, aesthetic, therapeutic, functional or other efficacy, which is not provided by the primary article, thereby providing a personal care kit. Can be formed. The additional article of the personal care kit preferably includes a water-insoluble substrate comprising one or more layers and a foaming surfactant-containing cleansing component or therapeutically effective component placed on or embedded in the substrate layer of the additional article. do.

Additional articles of the invention will also provide functional efficacy in addition to or in place of therapeutic or aesthetic efficacy. In such cases, the additional component may be useful as a drying tool suitable for use in assisting removal of water from the skin or hair upon completion of a shower or bathing.

Surface Saturation Ratio Measurement

An article of the present invention comprising a therapeutically potent component has a therapeutically potent component substantially on the surface of the substrate. “Substantially on the surface of the substrate” means that the surface saturation ratio is greater than about 1.25, preferably greater than about 1.5, more preferably greater than about 2.0, even more preferably greater than about 2.25, most preferably greater than 2.5. it means. Surface saturation ratio is the measurement ratio of agonists on the surface of a substrate. This measurement is obtained with an Attenuated Total Reflectance (ATR) FT-IR spectrometer whose use is well known to those skilled in the art of analytical chemistry.

Many conventional methods of applying the conditioning agent to a substrate employ processes and / or product rheology that are inadequate for the purposes of the present invention. For example, after immersing the substrate network in a fluid bath of conditioning agent, the conditioning agent is applied to the entire substrate in a so-called "dip and nip" process, a process of pressing the substrate network through a metering roll. There is no opportunity for effective direct delivery of the composition out on the fabric and another surface during use. In addition, many of the articles of the present invention provide effective overall body benefit with sufficient load of conditioning agent on the substrate, and typically require a loading rate of about 100-200% by weight based on the dry substrate. Known personal care tools that utilize this high load level essentially avoid the contact with aesthetic problems that may result from the high load by distributing the load evenly throughout the substrate, including inside the substrate. Applicants are surprisingly improved by the compositions of the present invention, while a high load conditioning agent can be maintained on the surface of the article, thus advantageously providing an opportunity for direct delivery of the agonist from the substrate to the surface to be treated during use. It has been found that the aesthetic agent can be delivered.

The procedure for the measurement is as follows:

Instrument Setup: Infrared spectra are collected using a BioRad FTS-7 spectrometer manufactured by BioRad Labs (Digital Laboratory Division, Cambridge, MA). Typically, the measurement consists of 100 scans at a resolution of 4 cm ⁻¹ . Acquisition Optics is available from Graseby Specac, Inc. A plate made from (Fairfield, CT) consists of a 60 degree ZnSe ATR crystal. Data is collected at 25 ° C. and analyzed using Grams 386 software distributed by Galactic Industries Corp. (Salem, NH). The crystals are washed with a suitable solvent before the measurement. Samples are placed on ATR crystals and kept under a constant 4 kg weight.

Experimental procedure:

(1) Measure the reference (background) spectrum of the washed and air dried cells.

(2) First, a substrate to which no agonist has been applied is selected, and the selected substrate includes the outer surface of the article. The substrate is placed on top of the ATR crystal so that the crystal abuts the outer surface. First, lay the substrate flat on the bench. Then 4 kg weight is placed on top of the substrate. The spectrum is then measured (typically 100 scans at 4 cm ^-1 resolution). Since the absorbance of the substrate alone is identified, the substrate serves as an internal standard. Identify major substrate peaks and wavelength numbers.

(3) The above procedure is repeated for the substrate of the article to which the agonist is applied. Does not correspond to a substrate peak as previously observed; The peak height of the primary agonist, which corresponds to the previously observed substrate peaks but which shows the greatest percentage increase in absorbance due to the presence of the conditioning agent, is identified. Record the wavelength and absorbance of some agonist peaks.

(4) From the spectrum determined in step 3, select a substrate peak that occurs at the number of wavelengths determined in step 2 but does not correspond to one of the primary agonist peaks selected in step 3. The number of wavelengths selected and the absorbance from the absorption spectrum of step 3 are recorded.

(5) Calculate the ratio of the peak height of each agonist determined in step 3 to the peak height of the substrate determined in step 4. The highest number of groups represents the surface saturation ratio of the article.

Some examples are included below:

temperament* Substrate Peak and Peak Height conditioner for hair Conditioner peak height ratio Batting (Combination of 70% PET / PE Bicomponent Fiber and Heat Bonded Polyester) 0.0865 (C = O peak at 1710 cm ^-1 ) Glycerin (CO peak at 1030 cm ^-1 ) 0.181 2.09 Batting (blending of polyester bonded with 70% PET / PE bicomponent fiber) 0.0865 (C = O peak at 1710 cm ^-1 ) Hydrocarbons (CH peak at 2923 cm ^-1 ) 0.160 1.85 Hydrated woven rayon 70% / polyester 30% 0.0333 (C = O peak at 1710 cm ^-1 ) Glycerin (CO peak at 1030 cm ^-1 ) 0.0684 2.05

Substrates of this type are readily available, for example, from PGI Nonwovens (Benson, NC).

Water retention measurement

As described above, articles of the present invention are considered to be "substantially dry." As used herein, "substantially dry" means that an article of the present invention has less than about 0.95 gms, preferably less than about 0.75 gms, more preferably less than about 0.5 gms, even more preferably less than about 0.25 gms, and more Preferably less than about 0.15 gms, most preferably less than about 0.1 gms. Moisture retention is the feeling of dryness that a user perceives upon contact with an article of the present invention, as opposed to the feeling of a “wet” wipe. It is a sign of.

In order to measure the moisture retention of the article and other disposable substrate-based products, the following equipment and materials are required.

Bounty White Paper Towel Procter & Gamble SKU 37000 63037 Base Mass = 42.14 gms Scale Accuracy up to 0.0 g Lexan 0.5 "thick, 1000 g weight, large enough to fully cover the specimen Weight 2000 g weight or combined 2000 g

The two paper towels are then weighed separately and each weight is recorded. One paper towel is placed on a flat surface (eg a laboratory bench). Place the sample article on top of the towel. Place another paper towel on top of the specimen. The lexan is then placed, and then placed on top of the sample article sandwiched between 2000 g weights. Wait for 1 minute After 1 minute, the weights and lexan are removed. Weigh the upper and lower paper towels and record the weight.

Moisture retention is calculated by subtracting the initial paper towel weight from the final weight (after 1 minute) for both the upper and lower paper towels. The weight difference obtained in the top and bottom paper towels is added. Assuming multiple articles have been tested, the overall weight difference is averaged to obtain moisture retention.

Multi-chambered Embodiment

Articles of the invention may also include one or more chambers. The chamber or partition is created in the connection (eg, bonding) of the substrate layers to each other at various locations to define the enclosed area. Such chambers are useful for, for example, separating surfactant-containing cleansing components from various article components, such as conditioning agents. Separated article components that provide therapeutic or aesthetic or cleansing efficacy include, but are not limited to, solubilizing, emulsifying, mechanically delivering, stabbing, bursting, exploding, ejecting, or even peeling off the substrate layer that forms part of the chamber. May be released from the chamber in a variety of ways.

Optional ingredients

Articles of the present invention may include a variety of other ingredients, such as those commonly used in a given product type, as long as they do not unacceptably alter the efficacy of the present invention. The optional ingredient should be suitable for application to human skin and hair, ie when introduced into an article, within the judgment of the appropriate physician or formulator, without inappropriate toxicity, incompatibility, instability, allergic reactions, etc. Suitable for use in contact with skin. The CTFA Cosmetic Ingredient Handbook, 2nd Edition (1992) describes a wide variety of non-limiting cosmetic and pharmaceutical components commonly used in the skin care industry, suitable for use in the articles of the present invention. Examples of such component groups include: enzymes, abrasives, skin exfoliants, absorbents, aesthetic components such as fragrances, pigments, dyes / colorants, essential oils, skin sensates, astringents and the like (e.g., clove oil, menthol, Camphor, eucalyptus oil, eugenol, menthyl lactate, witch hazel distillate), anti-acne agents (e.g. resorcinol, sulfur, salicylic acid, erythromycin, zinc, etc.), agglomeration (caking) ) Inhibitors, antifoams, additional fungicides (e.g. iodopropyl butylcarbamate), antioxidants, binders, biological additives, buffers, bulking agents, chelating agents, chemical additives, colorants, cosmetic astringents, cosmetics Biocides, denaturants, medicinal astringents, external analgesics, film formers or materials, for example polymers that assist the film-forming properties and identities of the compositions (eg, copolymerization of icosene and vinyl pyrrolidone) ), Wetting agents, opacifying agents, pH adjusting agents, propellants, reducing agents, sequestrants, skin bleach (or whitening agents) (e.g. hydroquinone, kojic acid, ascorbic acid, magnesium ascorbyl phosphate, ascorbyl glucosamine), skin Sedatives and / or therapeutics (e.g. panthenol and derivatives (e.g. ethyl panthenol), aloe vera, pantothenic acid and derivatives thereof, allantoin, bisabolol and dipotassium glycyrrizinate), preventing, delaying skin wrinkles, Skin treatments (eg, alpha-hydroxy acids such as lactic acid and glycolic acid and beta-hydroxy acids such as salicylic acid), including agents for stopping and / or reversing, thickeners, hydrocolloids, particulate zeolites and vitamins And derivatives thereof (e.g., tocopherol, tocopherol acetate, beta carotene, retinoic acid, retinol, retinoid, retinyl palmitate, niacin, nia Amide, etc.). Articles of the invention may include carrier components as known in the art. The carrier may include one or more compatible liquid or solid fillers, diluents or carriers suitable for application to the skin or hair.

Articles of the invention may optionally include one or more of the above optional ingredients. Preferred articles optionally include vitamin compounds, skin treatments, anti-acne agents, anti-wrinkle agents, anti-skin atrophy agents, anti-inflammatory agents, local anesthetics, artificial tanning agents and accelerators, antibacterial agents, antifungal agents, sunscreen agents, antioxidants, skin exfoliants and combinations thereof A safety effective amount of a therapeutically effective ingredient is optionally included, including a therapeutically effective agent selected from the group consisting of: As used herein, “safely effective amount” is within the scope of the appropriate physician's judgment, but low enough to significantly induce a positive effect or efficacy, but low enough to avoid serious side effects (eg, inappropriate toxicity or allergic reactions), ie It means the amount of a compound or ingredient that provides a reasonable efficacy to risk ratio.

Optional ingredients useful herein may be classified by their therapeutic or aesthetic efficacy or their assumed mode of action. However, it is to be understood that the optional ingredients useful herein may in some cases provide one or more therapeutic or aesthetic effects, or act through one or more modes of action. Therefore, classifications herein are made for convenience and are not intended to limit the ingredients to the particular application or applications listed. Also, where applicable, pharmaceutically acceptable salts of the components are useful herein.

Vitamin compounds

Articles of the invention may include vitamin compounds, precursors and derivatives thereof. The vitamin compound may be in natural or synthetic form. Suitable vitamin compounds include vitamin A (e.g. beta carotene, retinoic acid, retinol, retinoid, retinyl palmitate, retinyl propionate, etc.), vitamin B (e.g. niacin, niacinamide, riboflavin, pantothenic acid, etc.). ), Vitamin C (eg, ascorbic acid, etc.), vitamin D (eg, ergosterol, ergocalciferol, cholecalciferol, etc.), vitamin E (eg, tocopherol acetate, etc.) and vitamin K (Eg, phytonadione, menadione, pthiocol, etc.) Compounds include, but are not limited to.

In particular, articles of the invention may include a safe effective amount of a vitamin B ₃ compound. Vitamin B ₃ compounds are described in co-pending US patent application Ser. No. 08 / 834,010, filed Apr. 11, 1997, WO 97/39733 A1, Oct. 30, 1997, which is incorporated herein by reference in its entirety. As is disclosed in the following), it is particularly useful for regulating skin condition. The therapeutic ingredient of the present invention, preferably from about 0.01% to about 50%, more preferably from about 0.1% to about 10%, even more preferably from about 0.5% to about 10%, even more preferably about 1% to about 5%, most preferably about 2% to about 5% of the vitamin B ₃ compound.

As used herein, "vitamin B ₃ compound" means a compound having the formula: Derivatives thereof; And salts of any of the foregoing:

Wherein R is -CONH ₂ (ie niacinamide), -COOH (ie nicotinic acid) or -CH ₂ OH (ie nicotinyl alcohol).

Typical derivatives of the vitamin B ₃ compounds include nicotinic acid esters, including non-vascular expandable esters of nicotinic acid, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxides, and niacinamide N-oxides. .

Examples of suitable vitamin B ₃ compounds are well known in the art and include a number of sources such as Sigma Chemical Company (St. Louis, MO); ICN Biomedicals, Inc. (Irvin, CA) and Aldrich Chemical Company (Milwaukee, WI).

Vitamin compounds can be included as substantially pure substances or as extracts obtained by suitable physical and / or chemical isolation from natural (eg plant) sources.

Skin treatment

Articles of the invention may include one or more skin treatments. Suitable skin therapeutics include those effective for preventing, delaying, stopping and / or reversing skin wrinkles. Examples of suitable skin treatments include, but are not limited to, alpha-hydroxy acids such as lactic acid and glycolic acid and beta-hydroxy acids such as salicylic acid.

Acne inhibitors

Examples of acne inhibitors useful in the articles of the present invention include keratoses such as salicylic acid (o-hydroxybenzoic acid), salicylic acid derivatives such as 5-octanoyl salicylic acid and resorcinol; Retinoids such as retinoic acid and derivatives thereof (eg cis and trans); Sulfur containing D and L amino acids and derivatives and salts thereof, especially N-acetyl derivatives thereof, preferred examples thereof being N-acetyl-L-cysteine; Lipoic acid; Benzoyl peroxide, octopyrox, tetracycline, 2,4,4'-trichloro-2'-hydroxy diphenyl ether, 3,4,4'-trichlorovanylide, azelaic acid and derivatives thereof, phenoxy Antibiotic and antibacterial agents such as ethanol, phenoxypropanol, phenoxyisopropanol, ethyl acetate, clindamycin and meclocycline; Sebostats such as flavonoids; And bile salts such as scynmnol sulfate and derivatives thereof, deoxycholate and cholate.

Anti Wrinkle and Skin Atrophy

Examples of anti-wrinkle and anti-skin atrophy agents useful in the articles of the present invention include retinoic acid and derivatives thereof (eg, cis and trans); Retinol; Retinyl esters; Niacinamide, salicylic acid and derivatives thereof; Sulfur containing D and L amino acids and derivatives and salts thereof, in particular N-acetyl derivatives, preferred examples thereof being N-acetyl-L-cysteine; Thiols such as ethane thiol; Hydroxy acid, phytic acid, lipoic acid; Lysophosphatidic acid, and skin dermabrasions (eg, phenol and the like).

NSAIDs

Examples of NSAIDS useful in the articles of the present invention include the following categories: propionic acid derivatives; Acetic acid derivatives; Phenoic acid derivatives; Biphenylcarboxylic acid derivatives; And oxycam. All of these NSAIDS are fully described in US Pat. No. 4,985,459, issued January 15, 1991 to Sunshine et al., Which is incorporated herein by reference in its entirety. Examples of useful NSAIDS include acetyl salicylic acid, ibuprofen, naproxen, venoxaprofen, flubiprofen, phenofene, fenbufen, ketoprofen, indoprofen, pirprofen, carpropene, oxaprozin, Pranopropene, miroprofen, thioxapropene, supropene, aminopropene, thiapropene acid, flupropene and bucloxane. Also useful are steroidal anti-inflammatory drugs, including hydrocortisone and the like.

Local anesthetics

Examples of topical anesthetics useful in the articles of the present invention include benzocaine, lidocaine, bupivacaine, chlorprocaine, dibucaine, ethidocaine, mepivacaine, tetracaine, diclonaine, hexylcaine, procaine, cocaine, Ketamine, pramoxin, phenol and their pharmaceutically acceptable salts.

Artificial tanning agents and accelerators

Examples of artificial tanning agents and promoters useful in the articles of the present invention include tyrosine esters such as dihydroxyacetaone, tyrosine, ethyl tyrosinate and phospho-DOPA.

Antibacterial and Antifungal Agents

Examples of antibacterial and antifungal agents useful in the articles of the invention include beta-lactam drugs, quinolone drugs, ciprofloxacin, norfloxacin, tetracycline, erythromycin, amikacin, 2,4,4'-trichloro-2'-hydride Oxydiphenyl ether, 3,4,4'-trichlorocarbanilide, phenoxyethanol, phenoxy propanol, phenoxyisopropanol, doxycycline, capreomycin, chlorhexidine, chlortetracycline, oxytetracycline, clindamycin, ethambutol, Hexamidine isethionate, metronidazole, pentamidine, gentamicin, kanamycin, linenemycin, methacycline, metheneamine, minocycline, neomycin, netylmycin, paromomycin, streptomycin, tobramycin, myconazole, tetracycline Hydrochloride, erythromycin, zinc erythromycin, erythromycin estoleate, erythromycin Tearate, amikacin sulfate, deoxycycline hydrochloride, capreomycin sulfate, chlorhexidine gluconate, chlorhexidine hydrochloride, chlortetracycline hydrochloride, oxytetracycline hydrochloride, clindamycin hydrochloride, ethambutol hydrochloride, metronidazole Hydrochloride, pentamidine hydrochloride, gentamicin sulfate, kanamycin sulfate, linemycin hydrochloride, methcycline hydrochloride, metheneamine hippurate, metheneamine mandelate, minocycline hydrochloride, neomycin sulfate, netylmycin sulfate Pate, Paromomycin Sulfate, Streptomycin Sulfate, Tobramycin Sulfate, Myconazole Hydrochloride, Amanpadin Hydrochloride, Amanpadin Sulpe Nitrate, octopyrox, parachlorometha xylenol, nystatin, tolnaftate, zinc pyrithione and clotrimazole.

Antiviral agents

Articles of the invention may further comprise one or more antiviral agents. Suitable antiviral agents include, but are not limited to, metal salts (eg, silver nitrate, copper sulfate, iron chloride, etc.) and organic acids (eg, malic acid, salicylic acid, succinic acid, benzoic acid, and the like). Certain compositions comprising additional suitable antiviral agents include co-pending US patent application Ser. No. 09 / 421,084 (Beerse et al.), Filed Oct. 19, 1999, respectively; 09 / 421,131 (Biedermann et al.); 09 / 420,646 to Morgan et al .; And 09 / 421,179 (Page et al.).

enzyme

Articles of the invention may optionally include one or more enzymes. Preferably, the enzyme is dermatologically acceptable. Suitable enzymes include, but are not limited to keratinase, proteases, amylases, subtilisin and the like.

Sunscreen

Sunscreen agents are also useful herein. A wide variety of sunscreens are disclosed in US Pat. No. 5,087,445 to Haffey et al. Feb. 11, 1992; US Patent No. 5,073,372, issued December 17, 1991 to Turner et al .; U.S. Patent No. 5,073,371 issued to Turner et al. On Dec. 17, 1991; And in Segarin et al., Cosmetics Science and Technology Ⅷ Chapter p. 189 and later, all of which are incorporated herein by reference in their entirety. Non-limiting examples of sunscreens useful in the compositions of the present invention include 2-ethylhexyl p-methoxycinnamate, 2-ethylhexyl N, N-dimethyl-p-aminobenzoate, p-aminobenzoic acid, 2-phenylbenz Imidazole-5-sulfonic acid, octocrylene, oxybenzone, homomentyl salicylate, octyl salicylate, 4,4'-methoxy-t-butyldibenzoylmethane, 4-isopropyl dibenzoylmethane, 3- Benzylidene camphor, 3- (4-methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide and mixtures thereof. Other useful sunscreens include those disclosed in US Pat. No. 4,937,370 issued June 26, 1990 to Sabatelli and US Pat. No. 4,999,186 issued March 12, 1991 to Sabatelli et al. Hereby incorporated by reference. Particularly preferred examples of the sunscreen include 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester of 2,4-dihydroxybenzophenone, 4-N, N- (of 4-hydroxydibenzoylmethane 2-ethylhexyl) methylaminobenzoic acid ester, 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester of 2-hydroxy-4- (2-hydroxyethoxy) benzophenone, 4- (2- 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester of hydroxyethoxy) dibenzoylmethane and mixtures thereof. The exact amount of sunscreen that can be employed will depend upon the sunscreen chosen and the desired sun protection index (SPF) to be obtained. SPF is commonly used to measure photoprotection of sunscreens against erythema. Which is hereby incorporated by reference in its entirety. Federal Register , Vol. 43, No. 166, pp. 38206-38269 (August 25, 1978).

Hydrocolloid

Hydrocolloids may also optionally be included in the articles of the present invention. Hydrocolloids are well known in the art and help to extend the useful life of the surfactants included in the cleansing components of the present invention so that the article can last through one or more entire showers or baths. Suitable hydrocolloids include xanthan gum, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl and ethyl cellulose, natural rubber, gudras guar gum, soybean rubber, natural starch, deionized starch (e.g., starch) Octenyl succinate) and the like, but is not limited thereto.

Pyrogenic zeolite

Zeolites and other compounds that exothermic when combined with water may also optionally be included in the articles of the present invention.

Hydrogel-forming Polymeric Gelling Agent

Articles of the invention may optionally include hydrogel-forming polymeric gelling agents and aqueous gels formed from water, ie, "hydrogels". If an aqueous gel is present, the article preferably contains about 0.1% to about 100% by weight of the water insoluble substrate, more preferably about 3% to about 50% by weight, most preferably about 5% to about 35 weight percent hydrogel forming polymeric gelling agent calculated on the dry weight of hydrogel forming polymeric gelling agent is included.

In general, the hydrogel forming polymeric gelling agent material of the present invention is at least partially crosslinked polymer prepared from polymerizable unsaturated acid-containing monomers that are water soluble or water soluble upon hydrolysis. This includes monoethylenically unsaturated compounds having one or more hydrophilic radicals, including but not limited to, olefinic unsaturated acids and anhydrides comprising one or more carbon-carbon olefinic double bonds. With respect to the monomers, water soluble means that the monomers are soluble in deionized water at 25 ° C. at a level of at least 0.2%, preferably at least 1.0%.

In the polymerization, the monomer units described above are generally from about 25 mol% to 99.99 mol%, more preferably from about 50 mol% to 99.99 mol%, most preferably about 75 of the polymeric gelling agent material (based on dry polymer weight). It will consist of an acid containing monomer that is at least mole%.

The hydrogel forming polymeric gelling agents herein are partially crosslinked to a sufficient degree, preferably to such a high degree that the resulting polymer does not exhibit a glass transition temperature (Tg) of less than about 140 ° C., and accordingly the term " Hydrogel-forming polymeric gelling agent "should mean a polymer that satisfies these parameters. Preferably the hydrogel forming polymeric gelling agent does not have a Tg of less than about 180 ° C., more preferably at a temperature of about 370 ° C. or more, and no Tg before decomposition of the polymer. Tg can be measured by differential scanning calorimetry (DSC) performed at a heating rate of 20.0 ° C./min with a sample of 5 mg or less. Tg is calculated as the midpoint between the start point and the end point of the heat flow change corresponding to the glass transition on the DSC heat capacity heating curve. The use of DSC for Tg measurement is well known in the art and described in B. Cassel and MP DiVito, "Use of DSC To Obtain Accurate Thermodynamic and Kinetic Data", American Laboratory, 1994. 1., pp 14-19 and [B. Wunderlich, Thermal Analysis , Academic Press, Inc., 1990.

The hydrogel forming polymeric material is characterized by being very absorbent and capable of retaining water in its absorbed or "gel" state. Preferred hydrogel forming polymeric gelling agents herein may be capable of absorbing at least about 40 g, preferably at least about 60 g / g, more preferably at least about 80 g / g water (deionized water) per g of gelling agent. will be. The value referred to herein as "absorption capacity" can be determined according to the procedure of the "Tea Bag" absorption test described above.

The hydrogel forming polymeric gelling agents herein will generally be at least partially crosslinked. Suitable crosslinkers are well known in the art and include, for example, (1) compounds having two or more polymerizable double bonds; (2) compounds having at least one polymerizable double bond and at least one functional group reactive with an acid containing monomeric material; (3) compounds having at least two functional groups reactive with acid containing monomer materials; And (4) polyvalent metal compounds capable of forming ionic crosslinks.

Crosslinking agents having two or more polymerizable double bonds include (i) di- or polyvinyl compounds such as divinylbenzene and divinyltoluene; (ii) di- or unsaturated mono- or polycarboxylic acids with polyols, including di- or triacrylic esters of polyols, such as, for example, ethylene glycol, trimethylol propane, glycerin or polyoxyethylene glycol Polyester; (iii) bisacrylamides such as N, N-methylenebisacrylamide; (iv) carbamyl esters obtainable by reacting polyisocyanates with hydroxyl group-containing monomers; (v) di- or poly-allyl ethers of polyols; (vi) di- or poly-allyl esters of polycarboxylic acids such as diallyl phthalate, diallyl adipate and the like; (vii) esters of unsaturated mono- or poly-carboxylic acids with mono-allyl esters of polyols, such as acrylic acid esters of polyethylene glycol monoallyl ethers; And (viii) di- or tri-allyl amines.

Crosslinkers having at least one polymerizable double bond and at least one functional group reactive with an acid containing monomeric material include N-methylol acrylamide, glycidyl acrylate and the like. Suitable crosslinkers having at least two functional groups reactive with acid containing monomer materials include glyoxal; Polyols such as ethylene glycol and glycerol; Polyamines such as alkylene diamines (eg ethylene diamine), polyalkylene polyamines, polyepoxides, di- or polyglycidyl ethers and the like. Suitable multivalent metal crosslinkers capable of forming ionic crosslinks include, for example, oxides, hydroxides and weak acids of alkaline earth metals (eg calcium, magnesium) and zinc, including calcium oxide and zinc diacetate. Salts (eg, carbonates, acetates, and the like).

Many crosslinkers of this type are described in detail in US Pat. No. 4,076,663, issued Feb. 28, 1978 to Masuda et al. And US Pat. No. 4,861,539, issued Aug. 29, 1989 to Allen et al. The entirety of which is incorporated herein by reference. Preferred crosslinkers include di- or polyesters, bisacrylamides and di- or tri-allyl amines of unsaturated mono- or polycarboxylic acid mono-allyl esters of polyols. Specific examples of particularly preferred crosslinking agents include N, N'-methylenebisacrylamide and trimethylol propane triacrylate.

The crosslinker will generally comprise about 0.001 mol% to 5 mol% of the resulting hydrogel-forming polymeric material. More generally, the crosslinker will comprise from about 0.01 mol% to 3 mol% of the hydrogel-forming polymeric gelling agent used herein.

The hydrogel forming polymeric gelling agents herein can be employed in their partially neutralized form. For the purposes of the present invention, the material is considered to be partially neutralized when at least 25 mol%, preferably at least 50 mol%, of the monomers used to form the polymer are acid group-comprising monomers neutralized with a base. . Suitable neutralizing base cations include hydroxides of alkali and alkaline earth metals (eg KOH, NaOH), ammonium, substituted ammonium and amino alcohols (eg 2-amino-2-methyl-1,3-propanediol, Amines such as diethanolamine and 2-amino-2-methyl-1-propanol). The percentage of total monomers used, which are neutralized acid group containing monomers, is referred to herein as "degree of neutralization". The degree of neutralization will preferably not exceed 98%.

Hydrogel forming polymeric gelling agents suitable for use herein are well known in the art and are described, for example, in US Pat. No. 4,076,663, issued May 28, 1978 to Masuda et al .; U.S. Patent 4,062,817 to Westerman, issued December 13, 1977; U.S. Patent 4,286,082 to Aug. 25, 1981 to Tsubakimoto et al .; US Pat. No. 5,061,259, issued October 29, 1991 to Goldman et al., And US Pat. No. 4,654,039, issued March 31, 1987 to Brandt et al. Is cited.

Hydrogel-forming polymeric gelling agents suitable for use herein are also described in US Pat. No. 4,731,067 to Le-Khac on March 15, 1988, US Pat. No. 4,743,244 to Le-Khac on May 10, 1988. US Patent No. 4,813,945 (March 21, 1989 to Le-Khac) US Patent No. 4,880,868 (March 14, 1989 to Le-Khac), US Patent No. 4,892,553 (Le-Khac) US Patent No. 5,026,784 (June 25, 1991 to Le-Khac) US Patent No. 5,079,306 (July 1, 1992 to Le-Khac), US Patent 5,151,465 issued September 29, 1992 to Le-Khac, US Patent 4,861,539 issued August 29, 1989 to Allen, Farrer and Flesher, and US Patent 4,962,172 to Allen, Farrer and Flesher 1990 10. 9. Grant, each of which is incorporated herein by reference in its entirety.

Suitable hydrogel forming polymeric gelling agents in particle form include Hoechst Celanese Corporation (Portsmouth, VA, USA) (Sanwet ^™ superabsorbent polymer), Nippon Shokubai, Japan (Aqualic ^™ , for example L-75, L-76), And Dow Chemical Company (Midland, MI, USA) (Dry Tech ^™ ).

Hydrogel-forming polymeric gelling agents in fiber form are described by Camelot Technologies Inc. (Leominster, MA, USA) (Fibersorb ^™ , for example SA 7200H, SA 7200M, SA 7000L, SA 7000 and SA 7300).

Articles of the invention may also include other hydrophilic gelling agents. The water contains not only carboxylic acid-containing polymers as described above, but also cellulose ethers (e.g., hydroxyethyl cellulose, methyl cellulose, hydroxy propyl, except those which exhibit a relatively low degree of crosslinking and exhibit a Tg of less than 140 ° C). Methyl cellulose), polyvinylpyrrolidone, polyvinylalcohol, guar rubber, hydroxypropyl guar rubber and xanthan gum, and various other water soluble or colloidal water soluble polymers. Of these additional hydrophilic gelling agents, acid containing polymers, in particular carboxylic acid containing polymers, are preferred. In particular, those comprising water-soluble polymers of acrylic acid cross-linked with polyalkenyl polyethers of polyhydric alcohols and optionally acrylate esters or polyfunctional vinylidene monomers are preferred.

Preferred copolymers useful in the present invention include 95 to 99% by weight of olefinically unsaturated carboxyl monomers selected from the group consisting of acrylic acid, methacrylic acid and ethacrylic acid; About 1 to about 3.5 weight percent of acrylate ester of the formula:

(Wherein R is an alkyl radical having 10 to 30 carbon atoms and R ₁ is hydrogen, methyl or ethyl); And polymerizable crosslinked polyalkenyl polyether 0.1 to 0.6 of a polyhydric alcohol comprising at least one alkenyl ether group per molecule, wherein the parent polyhydric alcohol comprises at least 3 carbon atoms and at least 3 hydroxyl groups. Polymers of the monomer mixture comprising% by weight.

Preferably, the polymer comprises about 96 to 97.9 weight percent acrylic acid and about 2.5 to about 3.5 weight percent acrylic acid ester, wherein the alkyl group has 12 to 22 carbon atoms and R ₁ is methyl, most preferably Acrylate ester is stearyl methacrylate). Preferably, the amount of crosslinked polyalkenyl polyether monomer is about 0.2 to 0.4 weight percent. Preferred crosslinked polyalkenyl polyether monomers are allyl pentaerythritol, trimethylolpropane diallylether or allyl sucrose. Such polymers are described in detail in US Pat. No. 4,509,949, issued April 5, 1985 to Huang et al., Which is incorporated herein by reference in its entirety.

Other preferred copolymers useful in the present invention include polymers comprising two or more monomer components, one being a monomeric olefinically unsaturated carboxylic acid and the other being a polyether, polyalkenyl of a polyhydric alcohol. If desired, additional monomeric materials may be present in the monomeric mixture in predominant proportions.

The first monomeric component useful in the preparation of the carboxyl polymers is an olefinically unsaturated carboxylic acid comprising at least one activated carbon-carbon olefinic double bond, and at least one carboxyl group. Preferred carboxylic acid monomers are acrylic acid having the formula:

(Wherein R ² is a substituent selected from the group consisting of hydrogen, halogen, and cyanogen (C = N) groups, monovalent alkyl radicals, monovalent alkali radicals and monovalent cycloaliphatic radicals). Among the above groups, acrylic acid, methacrylic acid and ethacrylic acid are most preferred. Another useful carboxyl monomer is maleic anhydride or maleic acid. The amount of acid used will be about 95.5 to about 98.9 weight percent.

A second monomeric component useful for the preparation of the carboxyl polymer includes polyolefins having more than one alkenyl ether group per molecule, such as alkenyl groups, wherein an olefinic double bond is attached to the terminal methylene group CH ₂ = C <. Alkenyl polyethers.

Additional monomeric materials that may be present in the polymer include, for example, polyfunctional vinyls comprising two or more terminal CH ₂ <groups, including butadiene, isoprene, divinyl benzene, divinyl naphthylene, allyl acrylate, and the like. Leeden monomers are included. Such polymers are described in detail in US Pat. No. 2,798,053, issued to Brown, July 7, 1957, which is incorporated by reference in its entirety.

Examples of carboxylic acid copolymers useful in the present invention include Carbomer 934, Carbomer 941, Carbomer 950, Carbomer 951, Carbomer 954, Carbomer 980, Carbomer 981, Carbomer 1342, acrylate / C10-30 alkyl acrylate crosspolymers (BF, respectively). Sold by Goodrich in the Carbopol 934, Carbopol 941, Carbopol 950, Carbopol 951, Carbopol 954, Carbopol 980, Carbopol 981, Carbopol 1342, and Pemulen series.

Other carboxylic acid copolymers useful in the present invention include sodium salts of acrylic acid / acrylamide copolymers sold under the trade name Hostaceren PN73 by Hoechst Celanese Corporation. In addition, Lipo Chemicals Inc. Also included are hydrogel polymers sold under the trade name HYPAN hydrogel. The hydrogel consists of crystalline flicks of nitrate on the C-C backbone with various other protrusions such as carboxyl, amide, and amidine. Examples include HYPAN SA 100 H, a polymer powder commercially available from Lipo Chemical.

Neutralizers used to neutralize the acid groups of the polymer include those described above.

Cationic surfactant

Cationic surfactants are typically classified as non-bubbling surfactants, but can be used in articles of the present invention so long as they do not negatively affect the desired efficacy of the present article.

Non-limiting examples of cationic surfactants useful herein are described in McCutcheon's Detergents and Emulsifiers , North American edition (1986), allured Publishing Corporation; And McCutcheon's, Functional Materials , North American Edition (1992); Both are hereby incorporated by reference in their entirety.

Non-limiting examples of cationic surfactants useful herein include cationic alkyl ammonium salts, such as those having the formula:

_{R 1 R 2 R 3 R 4} N + X -

Wherein R ₁ is selected from about 12 to about 18 carbon atoms alkyl group, or about 12 to about 18 carbon atoms aromatic, aryl or alkaryl group; R ₂ , R ₃ and R ₄ are hydrogen, about 1 to Independently selected from alkyl groups of about 18 carbon atoms, or aromatic, aryl or alkaryl groups of about 12 to about 18 carbon atoms; X is chloride, bromide, iodide, acetate, phosphate, nitrate, sulfate, methyl sulfide Pate, ethyl sulfate, tosylate, lactate, citrate, glycolate, and mixtures thereof). Additionally, the alkyl group may also include ether bonds or hydroxy or amino group substituents (eg, alkyl groups may include polyethylene glycol and polypropylene glycol moieties).

More preferably, R ₁ is an alkyl group having from about 12 to about 18 carbon atoms; R ₂ is selected from H or an alkyl group of about 1 to about 18 carbon atoms; R ₃ and R ₄ are independently selected from H or an alkyl group of about 1 to about 3 carbon atoms; X is as described in the paragraph above.

Most preferably, R ₁ is an alkyl group having from about 12 to about 18 carbon atoms; R ₂ , R ₃ and R ₄ are selected from H or alkyl groups of about 1 to about 3 carbon atoms; X is as described above.

In contrast, other useful cationic surfactants include amino-amides, wherein R ₁ in the formula is optionally R ₅ CO— (CH ₂ ) _n −, wherein R ₅ is from about 12 to about 22 Alkyl group of n atoms, n is an integer of about 2 to about 6, more preferably about 2 to about 4, most preferably about 2 to about 3). Non-limiting examples of such cationic emulsifiers include stearamidopropyl PG-dimonium chloride phosphate, stearamidopropyl ethyldimonium etosulphate, stearamidopropyl dimethyl (myristyl acetate) ammonium chloride, stearamidopropyl dimethyl Cetearyl ammonium tosylate, stearamidopropyl dimethyl ammonium chloride, stearamidopropyl dimethyl ammonium lactate, and mixtures thereof.

Non-limiting examples of quaternary ammonium salt cationic surfactants include cetyl ammonium chloride, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide Lauryl dimethyl ammonium chloride, lauryl dimethyl ammonium bromide, stearyl dimethyl ammonium chloride, stearyl dimethyl ammonium bromide, cetyl trimethyl ammonium chloride, cetyl trimethyl ammonium bromide, lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, stearyl trimethyl Ammonium Chloride, Stearyl Trimethyl Ammonium Bromide, Lauryl Dimethyl Ammonium Chloride, Stearyl Dimethyl Cetyl Ditallow Dimethyl Ammonium Chlora Dide, Dicetyl Ammonium Chloride, Dicetyl Ammonium Bromide, Dilauryl Ammonium Chloride, Dilauryl Ammonium Bromide, Distearyl Ammonium Chloride, Distearyl Ammonium Bromide, Detyl Methyl Ammonium Chloride, Detyl Methyl Ammonium Bromide, Dilauryl Methyl Ammonium Chloride, dilauryl methyl ammonium bromide, distearyl methyl ammonium chloride, distearyl dimethyl ammonium chloride, distearyl methyl ammonium bromide, and mixtures thereof. Additional quaternary ammonium salts include those in which the C12 to C22 alkyl carbon chains are derived from tallow fatty acids or coconut fatty acids. The term "tallow" generally refers to alkyl groups derived from tallow fatty acids (generally hydrogenated tallow fatty acids) having a mixture of alkyl chains in the range of C16 to C18. The term "coconut" generally refers to an alkyl group derived from coconut fatty acid having a mixture of alkyl chains in the range of C12 to C14. Examples of quaternary ammonium salts derived from the tallow and coconut sources include ditallow dimethyl ammonium chloride, ditallow dimethyl ammonium methyl sulfate, di (hydrogenated tallow) dimethyl ammonium chloride, di (hydrogenated tallow) dimethyl ammonium acetate, dital Low Dipropyl Ammonium Phosphate, Ditlow Dimethyl Ammonium Nitrate, Di (coconutalkyl) dimethyl Ammonium Chloride, Di (coconutalkyl) dimethyl Ammonium Bromide, Tallow Ammonium Chloride, Coconut Ammonium Chloride, Stearamidopropyl PG-Dimonium Chloride Phosphate , Stearamidopropyl ethyldimonium etosulphate, stearamidopropyl dimethyl (myristyl acetate) ammonium chloride, stearamidopropyl dimethyl cetearyl ammonium tosylate, stearamidopropyl dimethyl ammonium chloride , Stearic amino also includes the profile dimethyl ammonium lactate, and mixtures thereof.

Preferred cationic surfactants useful herein include the group consisting of dilauryl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, dimyristyl dimethyl ammonium chloride, dipalmityl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, and mixtures thereof Included are those selected from.

Chelators

Articles of the invention may also include a safe effective amount of a chelator or chelating agent. As used herein, "chelator" or "chelating agent" means an active agent capable of removing metal ions from the system by forming a complex such that the metal ions cannot easily react or catalyze a chemical reaction. The introduction of chelating agents is particularly useful to provide protection against UV radiation, which can contribute to excessive scaling or skin texture changes, and other environmental factors that can cause skin damage.

A safe effective amount of chelating agent can be added to the compositions of the present invention, preferably from about 0.1% to about 10%, more preferably from about 1% to about 5% of the composition. Examples of chelators useful herein are described in US Pat. No. 5,487,884 to Bisett et al. Jan. 30, 1996; International Publication No. 91/16035 (published October 31, 1995 to Bush et al.); And International Publication No. 91/16034 (published October 31, 1995 to Bush et al.). Preferred chelators useful in the compositions of the present invention are furyldioxime and derivatives thereof.

Flavonoids

Articles of the invention may optionally include a flavonoid compound. Flavonoids are widely disclosed in US Pat. Nos. 5,686,082 and 5,686,367, both of which are incorporated herein by reference in their entirety. Flavonoids suitable for use in the present invention include flavanones selected from the group consisting of unsubstituted flavanones, monosubstituted flavanones, and mixtures thereof; Chalcones selected from the group consisting of unsubstituted chalcones, monosubstituted chalcones, disubstituted chalcones, trisubstituted chalcones, and mixtures thereof; Flavones selected from the group consisting of unsubstituted flavones, monosubstituted flavones, disubstituted flavones, and mixtures thereof; One or more isoflavones; Coumarins selected from the group consisting of unsubstituted coumarins, monosubstituted coumarins, disubstituted coumarins, and mixtures thereof; Chromones selected from the group consisting of unsubstituted chromones, monosubstituted chromons, disubstituted chromons, and mixtures thereof; One or more dicumarols; One or more chromanones; One or more chromanols; Their isomers (eg cis / trans isomers); And mixtures thereof. As used herein, the term "substituted" means a flavonoid in which one or more hydrogen atoms of a flavonoid are independently replaced by hydroxyl, C1-C8 alkyl, C1-C4 alkoxyl, O-glycoside, or the like, or a mixture of such substituents. do.

Examples of suitable flavonoids include, unsubstituted flavanones, mono-hydroxy flavanones (eg, 2'-hydroxy flavanones, 6-hydroxy flavanones, 7-hydroxy flavanones, etc.), mono-alkoxy flavanones. Banone (eg 5-methoxy flavanone, 6-methoxy flavanone, 7-methoxy flavanone, 4'-methoxy flavanone, etc.), unsubstituted chalcones (especially unsubstituted trans-chalcones), mono -Hydroxy chalcones (eg 2'-hydroxy chalcones, 4'-hydroxy chalcones, etc.), di-hydroxy chalcones (eg 2 ', 4-dihydroxy chalcones, 2', 4 ') Dihydroxy chalcones, 2,2'-dihydroxy chalcones, 2 ', 3-dihydroxy chalcones, 2', 5'-dihydroxy chalcones, and the like, and trihydroxy chalcones (eg, 2 ', 3', 4'-trihydroxy chalcone, 4,2 ', 4'-trihydroxy chalcone, 2,2', 4'-trihydroxy chalcone, etc.), unsubstituted flavone, 7,2'- Dihydroxy flavone, 3 ', 4'-dihydroxy naphthoflavone, 4'-hydroxy flavone, 5,6-benzople Bones, and 7,8-benzoflavones, unsubstituted isoflavones, dydzein (7,4'-dihydroxy isoflavones), 5,7-dihydroxy-4'-methoxy isoflavones, soybean isoflavones (Mixture extracted from soybean), unsubstituted coumarin, 4-hydroxy coumarin, 7-hydroxy coumarin, 6-hydroxy-4-methyl coumarin, unsubstituted chromone, 3-formyl chromone, 3-formyl -6-isopropyl chromone, unsubstituted dicoumarol, unsubstituted chromanone, unsubstituted chromanol and mixtures thereof, but are not limited thereto.

Unsubstituted flavanones, methoxy flavanones, unsubstituted chalcones, 2 ', 4-dihydroxy chalcones and mixtures thereof are preferred for use herein. Most preferred are unsubstituted flavanones, unsubstituted chalcones (especially trans isomers), and mixtures thereof.

These may be synthetic or obtained as extracts from natural sources (eg plants). The natural source material may be further derivatized (eg, glycoside, ester or ether derivatives prepared after extraction from the natural source). Flavonoid compounds useful herein include a number of sources, for example Indofine Chemical Company, Inc. (Somerville, New Jersey), Steraloids, Inc. (Wilton, New Hampshire), and Aldrich Chemical Company, Inc. (Milwaukee, Wisconsin).

Mixtures of the above flavonoid compounds may also be used.

The flavonoid compounds described herein are preferably present at a concentration of about 0.01% to about 20%, more preferably about 0.1% to about 10%, most preferably about 0.5% to about 5% in the present invention.

Sterol

Articles of the invention may include a safe effective amount of one or more sterol compounds. Examples of useful sterol compounds include cytosterol, stigmasterol, campesterol, brassicasterol, lanosterol, 7-dihydrocholesterol, and mixtures thereof. These may be of combination (eg phytosterols) of synthetic origin or extracted from natural sources such as plant sources.

Anticellulite

Articles of the invention may also include a safe effective amount of an anticellulite agent. Suitable materials may include, but are not limited to, xanthine compounds (eg, caffeine, theophylline, theobromine, and aminophylline).

Skin whitening agent

Articles of the invention may include skin lightening agents. When used, the composition preferably contains about 0.1% to about 10% by weight of the composition, more preferably about 0.2% to about 5% by weight, more preferably about 0.5% to about 2% by weight of the skin. Whitening agents are included. Suitable skin lightening agents include those known in the art, including kojic acid, arbutin, ascorbic acid and derivatives thereof such as magnesium ascorbyl phosphate or sodium ascorbyl phosphate or other salts of ascorbyl phosphate. do. Skin lightening agents suitable for use herein also include co-pending patent application Ser. No. 08 / 479,935, filed by Hillbrand on June 7, 1995, and corresponding PCT application US 95/07432, filed on June 12, 1995. )); And co-pending patent application Ser. No. 08 / 390,152 (Kalla L. Kvalnes, Mitchell A. DeLong, Barton J. Bradbury, Curtis B. Motley and John D. Carter, filed February 24, 1995, corresponding PCT application) Included are those described in US 95/02809 (published March 1, 95, 9. 8.).

Binder

Articles of the invention may optionally include a binder. The binder or binding material is useful for sealing the various layers of the article of the present invention to each other to maintain the integrity of the article. The binder may be in various forms, including, but not limited to, spraying, netting, individual layers, binding fibers, and the like. Suitable binders may include latex, polyamides, polyesters, polyolefins and combinations thereof.

Additional layer

In another embodiment, an article of the present invention may include one or more additional layers, which are recognized by those skilled in the art as separate and distinct from the first layer and the second layer, but are attached to the two layers at the same point. The additional layer is suitable for enhancing the overall grippability of the side of the article closest to the hand or other means, in order to exert a mechanical action on the surface to be cleansed. In addition, the additional layer is suitable for enhancing the soft feel of the side of the article in contact with the area to be cleansed and / or treated therapeutically. In all cases, the additional layer may also be called a continuous numbered layer, for example a third layer, a fourth layer, etc., in addition to the two essential layers of the article of the invention.

Suitable additional layers can be expanded macroscopically. As used herein, " macroexpanded " means that when the vertical distance between the observer's eye and the plane's plane is about 12 inches, the surface deformation comprising the pattern is normal to the naked eye (ie normal to eye with 20/20 vision) By individually distinguishable, it is meant nets, ribbons, and films that are fitted to the surface of a three-dimensional molded structure such that both surfaces exhibit a three-dimensional molded pattern of surface deformation corresponding to the macroscopic cross section of the molded structure.

As used herein, "embossed" means that the molding structure of the material exhibits a pattern consisting mainly of male-projection. On the other hand, "debossed" means that the forming structure of the material exhibits a pattern consisting mainly of recessed capillary networks.

Preferred macroscopically expanded films include molded films that are structural elastomeric films. Such films are described in US Pat. No. 5,554,145, issued September 10, 1996 to Roe et al., Which is incorporated herein by reference in its entirety.

Materials suitable for use in additional layers having a thickness of at least 1 millimeter include, but are not limited to, the net material disclosed in US Pat. No. 5,518,801 to May 21, 1996, to Chappell et al. Hereby incorporated by reference.

Manufacturing method

Personal care articles of the present invention may include, but are not limited to, sprinkling, dip coating, spraying, slot coating, and roll delivery (eg, pressure rolls or kiss rolls). It is prepared by adding a cleansing ingredient and / or therapeutic efficacy ingredient to an appropriate sheet of the first layer or the second layer, via conventional methods, but not by conventional methods. The sheet of residual layer is then placed on the sheet of the first layer, preferably but not always, across the cleansing component and / or therapeutic efficacy component. The sheets are closed together by conventional sealing methods, including but not limited to heat, pressure, adhesive, ultrasonic waves, and the like. Heat sealing devices can vary in design and, if they cannot perform sealing, low melting, such as polyamide fiber mesh known as Wonder Under (manufactured by Pelon and sold by H. Levinson & Co., Chicago, IL). Insert layers of heat sealable fiber nets may be used between the layers of this and other embodiments without changing the effect or use of the article. The sealed sheet is then divided into units suitable for the consumer's use. Optional manufacturing steps may include calendaring, drying, creping, shrinking, stretching, or other mechanical deformation to flatten the article.

Cleansing to skin or hair and delivery of therapeutic or cosmetic agonists

The invention also relates to a method of cleansing skin or hair with the personal care article of the invention. The method includes the following steps: a) A substantially dry disposable personal care article suitable for cleansing, wherein the article has a soft first layer exhibiting an overall scratch cover value of less than about 17% and a peeling placed near the first layer. A water-insoluble substrate comprising a solvent second layer (the second layer exhibits an overall scratch cover value of about 17% to about 70%); and a cleansing component placed near the first and second layers (the component (Includes a foaming surfactant that is from about 10% to about 1000% by weight of the water-insoluble substrate).) Wetting with water and b) contacting the wet article with skin or hair. Additionally, the present invention relates to a method of cleansing skin and hair, comprising the steps of: a) a substantially dry disposable personal care article suitable for cleansing, wherein the article has an average profilometer depth value of less than about 8; A water-insoluble substrate comprising a soft first layer, wherein said water-insoluble substrate comprises a second layer for exfoliation adjacent to said first layer, said second layer having an average profilometer depth value of about 8 to about 80; and Wetting a cleansing component in the vicinity of the first and second layers, the component comprising a foaming surfactant that is about 10% to about 1000% by weight of the water-insoluble substrate; And b) contacting the wet article with skin or hair.

Additional methods include similar steps using articles exhibiting the remaining physical properties disclosed herein.

In another embodiment, the present invention is useful for delivering a therapeutically effective component to a site (eg, skin, hair, etc.) in need of treatment, wherein the method includes the following additional steps: A ) A substantially dry disposable personal care article as described in the paragraph above; And 2) moistening a therapeutically effective component placed near the water-insoluble substrate, wherein the component comprises a therapeutic agonist that is about 10% to about 1000% by weight of the water-insoluble substrate; And B) contacting the skin or hair with a wet article.

The article of the invention must be water-activated and therefore wetted with water before use. As used herein, "water-activated" means that the present invention is provided to the consumer in a dry form which should be used after wetting with water. When foaming surfactants are included in the articles of the invention, they are found to foam or “activate” after contact with water and then stirring. Thus, the article is wetted by soaking in water or placing it under a stream of water. If the article of the present invention includes a foaming surfactant in the cleansing component, foam may be generated from the article by mechanically stirring and / or deforming the article before or during the article's contact with skin or hair. The resulting foam is useful for cleansing the skin or hair. During the cleansing process and subsequent rinsing with water, any therapeutic or aesthetic agonist is deposited on the skin or hair. The deposition of therapeutic or aesthetic agonists is enhanced by the introduction of one or more deposition aids, as well as by physical contact of the substrate with the skin or hair.

The present invention relates to disposable personal care articles useful for the therapeutic treatment and cleansing of the skin, hair and any other location in need of treatment. The article includes a soft first layer exhibiting a Total Scratch Coverage Value of less than about 17% and a second layer for exfoliation adjacent to the first layer, wherein the second layer is from about 17% to about 70 Water insoluble substrate); And a cleansing component comprising a foaming surfactant that is from about 10% to about 1000% by weight of the water-insoluble substrate or from about 10% to about 1000% by weight of the water-insoluble substrate. Or both. The article also includes a soft first layer exhibiting an average Profilometer Depth Value of less than about 8 and a second layer in the vicinity of the first layer, wherein the second layer is from about 8 to about 80 Water insoluble substrate); And a therapeutically effective component comprising a cleansing component comprising a foaming surfactant that is about 10% to about 1000% by weight of the water-insoluble substrate or a therapeutic agonist that is about 10% to about 1000% by weight of the water-insoluble substrate. Or both. The consumer uses the articles by moistening them with water, rubbing them on the areas to be cleansed and / or treated therapeutically (eg, to be conditioned).

The invention also includes methods of cleansing and / or conditioning skin and hair using the articles of the invention.

The following examples further describe and demonstrate embodiments within the scope of the invention. In the examples below, all components are listed by activity level. The examples are provided for illustrative purposes only, and many variations thereof are possible without departing from the spirit and scope of the invention and should not be construed as limiting the invention.

Components are identified by their chemical name or CTFA name.

I. Cleansing ingredients

Example 1

Representative cleansing ingredients for the articles of the invention are prepared in the following manner.

Cut 53.0 gms of bar soap containing the following ingredients:

ingredient weight% Sodium kosyl isethionate 27.77 paraffin 16.72 Sodium Alkyl Glycerol Sulfonate (AGS) 14.90 soap 11.41 glycerin 8.57 water 5.50 Stearic acid 5.74 Sodium isethionate 3.04 NaCl 1.41 EDTA 0.10 Etidronic acid 0.10 Polyox 0.03 Spices 0.70 Others (including pigments) 4.01 synthesis 100

The bar soap crumbs are mixed with 37.0 gms of glycerin (99.7%), 9.5 gms of water, and 0.5 gms of fragrance. The mixture is heated to 200 ° F. with continued stirring. The mixture is cold-milled in a standard 3-roll mill and the cleansing ingredients are stored in a suitable sealed container.

Example 2

Representative cleansing ingredients for the articles of the invention are prepared in the following manner.

Cut 40.0 gms of bar soap containing the following ingredients:

ingredient weight% Sodium soap 52.40 Sodium Alkyl Glycerol Sulfonate (AGS) 16.50 Magnesium soap 13.40 glycerin 0.19 water 5.50 Stearic acid 1.60 Sodium isethionate 3.00 NaCl 3.89 EDTA 0.10 Etidronic acid 0.10 Spices 0.70 Others (including pigments) 2.62 synthesis 100

The bar soap crumb is mixed with 45.0 gms of glycerin (99.7%), 4.5 gms of water, and 0.5 gms of fragrance. The mixture is heated to 200 ° F. with continued stirring. The mixture is cold-milled in a standard 3-roll mill and the cleansing ingredients are stored in a suitable sealed container.

Example 3

Representative powder cleansing ingredients for the articles of the invention are prepared in the following manner.

Cut 40.0 gms of bar soap containing the following ingredients:

ingredient weight% Soap (Magnesium and Sodium) 80.16 water 11.50 Stearic acid 5.70 NaCl 1.10 EDTA 0.25 Spices 1.15 Others (including pigments) 0.14 synthesis 100

Bar soap flakes are stored in a suitable sealed container.

Example 4

Representative powder cleansing ingredients for the articles of the invention are prepared in the following manner.

Cut 40.0 gms of bar soap containing the following ingredients:

ingredient weight% Soap (Magnesium and Sodium) 80.16 water 11.50 Stearic acid 5.70 NaCl 1.10 EDTA 0.25 Spices 1.15 Others (including pigments) 0.14 synthesis 100

The bar soap flakes are combined with sodium bicarbonate in a weight ratio of 90:10. The mixture is ground twice in a standard 3-roll mill. The flakes are collected and stored in a properly sealed container.

Example 5

Representative cleansing ingredients for the articles of the invention are prepared in the following manner. The cleansing component of Example 2 is combined with 0.1% by weight of bar soap flakes of the protease enzyme. The resulting mixture is then combined with sodium carboxymethylcellulose, a dry hydrocolloid with 2% by weight of cleansing components, and ground. Enzyme cleansing components are stored in a suitable sealed container.

Example 6

Representative liquid cleansing ingredients are prepared comprising the following ingredients.

ingredient weight% Sodium Coconut Alkyl Glyceryl Sulfonate (AGS) 7.2 Ammonium Lauryl Sulfate (ALS) 10.4 Alkyl Laurate Sulfate (AE3S) 10.4 PolyOx WSR N-3000, Union Carbide 0.5 Xanthan rubber 1.4 water 70.1

Example 7

Representative cleansing ingredients for the articles of the invention are prepared in the following manner. 3 lbs of the soap shavings of Example 2 are heated with 3/4 cup of isopropyl alcohol (99%) until the soap melts. When the soap is molten, the remaining alcohol is added. Table sugar dissolved in as little water as possible 10 oz. Add. Dye about 4 tsp. Glycerin 8 oz. Formulated in Glycerin (99.7%) is added. Stir. As the agitator is removed, the viscosity changes from a thin liquid to a rope-like ribbon and continues to heat until an aliquot of the material has cured when loaded onto a cold surface. The mixture is poured into a suitable container to cure. The mixture has the advantage of remelting during the heating process, which facilitates the process for making the article.

Example 8

A representative eye free liquid cleansing ingredient is prepared comprising the following ingredients.

ingredient weight% Cocamido Profile Betaine 17.1 Sodium Trideset Sulfate 8.3 POE 100 sorbitan monooleate 7.5 Others (including fragrances, preservatives, dyes) 2.0 water 65.1

A distinguishing feature of the composition is its non-irritating properties on skin and eyes.

Example 9

Representative liquid cleansing ingredients are prepared comprising the following ingredients.

ingredient weight% Polyquaternium 10 0.50 Sodium Lauro Ampo Acetate 5.4 Sodium Lauret 3 Sulfate 11.6 Disodium EDTA 0.20 Sodium citrate dihydrate 0.50 Citric Anhydride 1.0 PEG-6 caprylic / capric glycerides 2.0 Cocamide MEA 2.0 glycerin 3.5 MgSO ₄ -7H ₂ O (epsom salt) 1.5 Maleated Soybean Oil 2.5 Deodorized Soybean Oil 5.0 Others (including fragrances, caustics, colorants) 1.5 water 62.8

The mixture is gentle for use on sensitive skin.

Example 10

Representative liquid cleansing ingredients are prepared comprising the following ingredients.

ingredient weight% Polyquaternium-10 0.1 Sodium sulfate 1.5 Lauryl alcohol 0.3 Sodium Lauret Sulfate 5.8 Citric Anhydride 0.2 Cocamidopropyl Betaine 15.5 Sodium Lauroyl Sarcosinate 1.5 Others (including fragrances and blue colorants) 1.0 water 74.1

Example 11

Representative cleansing ingredients are prepared comprising the following ingredients.

ingredient weight% Decylpolyglucose 12.0 Cocamidopropyl Betaine 12.0 Sodium Lauroyl Sarcosinate 12.0 Butylene Glycol 3.6 PEG 14M 1.8 Polyquaternium-10 0.9 Dex panthenol 0.7 Phenoxyethanol 0.5 Benzyl alcohol 0.5 Methylparaben 0.45 Propylparaben 0.25 Disodium EDTA 0.2 water 55.1

Example 12

Representative cleansing ingredients are prepared comprising the following ingredients.

ingredient weight% EGDS 3.1 Cocamidopropyl Betaine 4.0 TEA soap (about 330 molecular weight) 9.5 Monoalkyl phosphates 15.0 Cocamine Oxide 7.5 1,2-propanediol 1.0 ethanol 3.0 Others (fragrances, colorants, preservatives) 8.9 water 48.0

The mixture is heated to 50 ° C. with continued stirring until the mixture loses 38% of its original weight and has a paste like viscosity. The cleansing component advantageously facilitates processing with the substrate layer and does not require further drying.

Example 13

Representative cleansing ingredients are prepared comprising the following ingredients.

ingredient weight% SEFA ^* Cotonate 57.5 Citric acid 0.30 Cocamidopropyl Betaine 3.5 Sodium Lauroyl Sarcosinate 10.7 Ethylene Vinyl Acetate Polymer (Elvax 40W) 8.0 Silicone Polymer Microbeads (Tospearly 145A) 20.0

^* SEFA is an acronym for sucrose esters of fatty acids.

The ethylene vinyl acetate polymer is melted with SEFA cotonate at 90 ° C. and high shear mixed. Add surfactant powder and citric acid and mix. Silicone polymer microbeads are added, mixed and allowed to cool. The composition is remeltable and easily permeates or coats the fabric.

Example 14

Representative cleansing ingredients are prepared comprising the following ingredients.

ingredient weight% Sodium Lauret-10 Carboxylate (Empicol CB5S ^* ) 50.0 C12-14, 12EO Alcohol Ethoxylate (Empilan KB12 ^* ) 50.0

^* Available from Albright & Wilson

The alcohol ethoxylate is melted, compounded in the carboxylate until homogeneous and cooled to solidify until available. The composition is remeltable and easily permeates or coats the fabric.

Example 15

Representative cleansing ingredients are prepared comprising the following ingredients.

ingredient weight% Monosodium lauroyl glutamate 22.0 Cocamidopropyl Betaine 2.0 Sodium chloride 1.0 glycerin 2.5 water 72.5

Heat the components together with gentle stirring until homogeneous.

Example 16

Representative cleansing ingredients are prepared comprising the following ingredients.

ingredient weight% Triethanolamine 2.9 Polyquaternium-39 0.1 Monolauryl phosphate 4.0 C ₁₂ -C ₁₄ N-methyl glucose amide ¹ 5.0 Cocamidopropylhydroxysultine ² 2.0 Sodium decyl sulfate 0.5 Citric Acid Monohydrate 0.3 Spices, Preservatives & More. 4.0 water 81.2

¹ Available from Hoechst Celanese

² Available from Rhone Poulenc

Add the ingredients slowly at 60 ° C. in the following order until each dissolves in water: TEA, lauryl phosphate, glucose amide. Cool to 45 ° C. and add sultaine, polyquaternium-39 and sulphate with stirring as described above. Add fragrance, preservative and cool to room temperature.

Example 17

The following components are mixed to prepare a representative cleansing component.

ingredient weight% Lauroyl Polyglucose ¹ 20.0 Cetyltrimethylammonium bromide 4.0 Spices, Preservatives & Others 4.0 water 72.0

¹ Henkel to Plantaren 1200 available

II. Therapeutic Efficacy Ingredients

Example 18-22

The following ingredients are mixed to make representative skin conditioning ingredients.

ingredient Example 18 Example 19 Example 20 Example 21 Example 22 SEFA ^* Cotonate 48.0 75.0 33.5 40.0 80.0 SEFA ^* Behenate 12.0 25.0 8.4 10.0 10.0 Petrolatum 10.0 - 7.0 - - Glyceryl Tribehenate 5.0 - 3.5 - - Stearyl alcohol - - - 5.0 - paraffin - - - 15.0 - Cholesterol ester 25.0 - 17.5 - - Ozokerite Wax - - - - 10.0 glycerin - - 28.0 - - Triglyceryl monostearate - - 1.9 - - Decaglyceryl Dipalmitate - - 0.2 - - Nonylphenol Polyglycine Ether ¹ - - - 30.0 -

^* SEFA is an acronym for sucrose esters of fatty acids.

¹ Hamplex TNP, Hampshire Chemical Co.

Example 23-27

The following ingredients are mixed to make representative skin conditioning ingredients.

ingredient Example 23 Example 24 Example 25 Example 26 Example 27 Petrolatum (White) 35.87 35.87 - - 34.0 Mineral oil 11.0 13.0 - - 10.0 Jojoba oil - - - 4.5 Perm free 10.0 9.0 - - Cocoa butter 5.0 Diisostearyl trimethylpropane siloxy silicate 20.0 20.0 - - Polydimethyl siloxane, 500 cSt fluid - - 0.7 1.5 Decamethylcyclopentasiloxane - - - 16.5 Octamethylcyclotetrasiloxane - - - 10.0 Rubber polydimethylsiloxane - - 5.9 7.5 Stearyl methicone wax - - - 3.0 Polybutene - - - 4.5 Candelilla wax 4.6 4.6 - - 6.0 Paraffin wax - - - 15.0 2.0 Microcrystalline wax - - - 6.0 4.0 beeswax 3.0 3.0 - - 4.0 Ozokerite Wax 6.0 6.0 - - Carnauba Wax 3.0 3.0 - - Hydrogenated castor oil 0.50 0.50 4.0 - Silica - - - 4.5 Sodium magnesium silicate - - - 1.5 Tocopherol 0.03 0.03 - - Cyclomethicone - - 59.0 - Stearyl alcohol - - 25.5 - 9.0 Cetyl alcohol 9.0 Glyceryl Stearate - - 2.6 - Acetylated Monoglycerides 15.0 Diisostearyl maleate ¹ - - - 6.0 Glyceryl Distearate - - - 9.5 glycerin - - - 6.0 water - - - 3.0 Nonylphenol Polyglycine Ether ² - - 5.0 - Undifferentiated Titanium Dioxide 5.0 - - Octyl methoxycinnamate 5.0 - - - Air Fresheners & More 1.0 1.0 1.0 1.0 2.0

¹ Eastman Chemical Co. Marketed as Myvacet 7-07, which is half acetylated

² Hampshire Chemical Co. Available on Hamplex TNP

Example 28

The following ingredients are mixed to make representative skin conditioning ingredients.

ingredient Example 28 Polydecene ¹ 53.3 Stearyl alcohol 7.7 12-hydroxystearic acid 13.5 Nonylphenol Polyglycine Ether 25.0 Octyl methoxycinnamate 1.5

¹ Puresyn 3000, Mobil Chemical Co.

Examples 29-31

The following ingredients are mixed to make representative skin conditioning ingredients.

ingredient Example 29 Example 30 Example 31 glycerin 95.0 95.0 94.0 Decaglyceryl dipalmitate ¹ 5.0 1.0 5.0 Deceglyceryl dibehenate 4.0 Tribehenin 1.0

¹ Lonza to Polyaldo 10-2-P

Example 32-36

Representative conditioning ingredients for the articles of the invention are prepared in the following manner.

ingredient Example 32 Example 33 Example 34 Example 35 Example 36 Minority Awards: SEFA ^* Cotonate 4.65 4.65 15.5 15.5 SEFA ^* Behenate 0.35 0.35 8.0 8.0 Tribehenin 6.0 6.0 Petrolatum 4.0 4.0 4.4 Cocoa butter 15.5 C ₁₀ -C ₃₀ Cholesterol / Lanosterol Ester 13.0 13.0 C ₃₀ -C ₄₅ Alkylmethicone ¹ Polyglyceryl-4 isostearate (and) cetyl dimethicone (and) hexyl laurate ² 5.0 5.0 PEG 30 dipolyhydroxystearate ³ 3.0 Tetraglyceryl monostearate 2.1 Decaglyceryl Dipalmitate 0.90 Ceresin wax 5.5 beeswax 7.0 Tablets lecithin 10.0 1-monostearin 10.0 Hydrophilic award: glycerin 70.0 66.5 42.30 42.30 40.0 water 3.5 5.0 PVM / MA Decadiene Crosspolymer ⁴ 0.25 0.25 Sodium hydroxide (10% solution) 0.25 0.25 gelatin 2.6 Active Skin Care Components: Panthenol 20.0 10.0 2.50 Nicotinamide 5.0 2.50 3.0 Element 5.0 2.50 2.50 Allantoin 0.20 0.20 Acetamidopropyl trimonium chloride 2.0

^* SEFA is an acronym for sucrose esters of fatty acids.

¹ Available as Dow Corning by AMS-C30

² Marketed as Abil WE-09 by Goldschmidt

³ Marketed as Arlacel P135 by ICI

⁴ Stabileze 06 available from ISP

Process for all emulsions:

The hydrophobic phase is heated to 70 ° C. and the hydrophobic active skin care component is added and stirred until homogeneous. The hydrophilic active skin care component and the hydrophilic phase component are premixed and heated slowly to dissolve or disperse them if necessary. These are slowly added to the minor phase to continue stirring. Homogenize (high shear mixer; ultrasonic homogenizer; or high pressure homogenizer, such as Microfluidizer from Microfluidics Corp.). Apply immediately to the substrate surface, or quickly cool down to room temperature in ice or ice water. If necessary, store in a controlled environment under nitrogen for chemical stability.

Example 37-41

Using the following components, representative conditioning components are prepared as described in Examples 32-36.

ingredient Example 37 Example 38 Example 39 Example 40 Example 41 Minority Awards: SEFA ^* Cotonate 15.0 16.0 SEFA ^* Behenate 7.5 4.0 Tribehenin 6.0 Petrolatum 4.0 4.0 4.4 Cocoa butter 15.5 Polydecene ¹ 50.0 46.5 C10-C30 Cholesterol / Lanosterol Ester 13.0 10.5 PEG30 dipolyhydroxystearate 3.0 3.0 Ceresin wax 5.5 Beeswax 7.0 Aluminum / magnesium hydroxystearate ^{2 in} mineral oil 7.5 C30-38 Olefin / Isopropyl Maleate Copolymer ³ 2.5 Polyethylene wax ⁴ 1.0 Tablets lecithin 10.0 Air freshener and others 1.0 1-monostearin 10.0 Hydrophilic award: glycerin 30.0 25.0 34.80 20.0 38.0 water 8.0 8.0 5.0 PEG 2000 17.0 PVM / MA Decadiene Crosspolymer 0.25 Sodium hydroxide (10% solution) 0.25 gelatin 9.50 9.50 2.6 Active Skin Care Components: Nicotinamide 2.50 Methanol in 50% Beta Cyclodextrin 2.50 Ascorbic acid (natural) 2.50 Tocopherol (natural) 1.00 2.50 Sorbitol 2.50 Lactic acid 2.5 Element 2.50 Allantoin 0.20 Triclosan 1.50 Chlorhexidine 0.50 Benzoyl peroxide 5.0 15% Salicylic Acid in PPG 14 Butyl Ether 12.0 Salicylic acid 2.5

¹ Mobil to Puresyn 3000

² Giulini Chemie available as Gilugel Min

³ Available as Performa 1608 by New Phase Technologies

⁴ Marketed as Performalene 400 by New Phase Technologies

Example 42-46

Representative conditioning ingredients are prepared as described in Examples 32-36 using the following components.

ingredient Example 42 Example 43 Example 44 Example 45 Example 46 Minority Awards: SEFA ^* Cotonate 20.5 15.5 16.0 Mineral oil 7.50 SEFA ^* Behenate 8.0 8.0 8.0 Tribehenin 9.5 6.0 6.0 Petrolatum (white or ultra white) 4.0 4.0 22.6 3.0 4.0 Candelilla wax 4.50 Paraffin wax 3.00 14.0 Microcrystalline wax 1.50 Beeswax 3.00 C10-C30 Cholesterol / Lanosterol Ester 18.0 13.0 13.0 Laurylmethicone copolyol ¹ 5.0 Acetylated Monoglycerides ² 11.3 Stearyl alcohol 6.8 Cetyl alcohol stearic acid 6.8 PEG 30 dipolyhydroxystearate 4.5 3.0 Decaglyceryl Dipalmitate ³ 0.90 Tetraglyceryl monostearate 2.10 Air freshener, other 1.0 3.0 2.0 Hydrophilic award: glycerin 22.8 27.5 25.0 38.0 41.0 Decaglyceryl Dipalmitate ³ 2.5 Calcium Silicate Microspheres ⁴ 15.0 Active Skin Care Components: Guar hydroxypropyltrimonium chloride 1.00 Chitosan glycolate 2.50 Nicotinamide 1.50 2.50 2.50 0.2% Carbopol 940 aqueous solution, pH 6.0 38.0 Retinol 2.50 Phytantriol ⁵ 1.00 Element 2.50 3.0 2.50 Vitamin c 2.50 Borage Oil 2.50 Ascorville Palmitate 1.50 Acetamidopropyl trimonium chloride ⁶ 2.50

¹ Marketed by Dow Corning as Dow Q2-5200

² Eastman Chemical Co. About half as acetylated as Myvacet 7-07

^{3 from} Lonza to Polyaldo 10-2-P

⁴ Celite Co. Commercially available from Celite C

⁵ Henkel sold to Hydagen CMF by Henkel

⁶ available in Incromectant AQ from Croda

Example 43 Glycerin is incorporated into microspheres, then blended onto molten lipids and cooled during storage or applied to a substrate.

Example 47-52

Representative conditioning ingredients are prepared as described in Examples 32-36 using the following components.

ingredient Example 47 Example 48 Example 49 Example 50 Example 51 Example 52 Minority Awards: SEFA ^* Cotonate 16.0 16.0 16.0 16.0 16.0 16.0 Mineral oil SEFA ^* Behenate 8.0 8.0 8.0 8.0 8.0 Tribehenin 6.0 6.0 6.0 6.0 6.0 6.0 Petrolatum (white or ultra white) 4.0 4.0 4.0 4.0 4.0 4.0 C10-C30 Cholesterol / Lanosterol Ester 13.0 13.0 13.0 13.0 13.0 13.0 Stearyl Dimethicone 2.0 Dimethicone hydroxystearate 4.0 Dimethicone Copolyol Behenate 2.0 PEG 30 dipolyhydroxy stearate 3.00 3.00 Sodium Lauroyl Glutamate 2.00 Sodium stearoyl lactylate 2.00 Calcium stearate 5.0 Decaglyceryl Dipalmitate 0.90 0.90 0.90 0.90 Tetraglyceryl monostearate 2.10 2.10 2.10 2.10 Air freshener, other 1.00 1.00 1.00 1.00 1.00 1.00 Hydrophilic award: glycerin 44.5 42.5 35.5 35.5 25.0 43.0 75% Polyethylenimine in water ¹ , pH 6.5 4.50 4.50 water 2.0 Decaglyceryl Dipalmitate 2.50 2.50 Fumed silica 20.0 Propylene Glycol Alginate ² 2.0 Active Skin Care Components: Nicotinamide 2.00 2.00 Chitosan 1.50 Green tea extract 4.50 Aloe vera gel 3.0 Vitamin c 2.50 Ascorville Palmitate 2.00 2.50 Acetamidopropyl trimonium chloride 2.00 2.00

¹ Nippon Shokubai Co. Marketed as Epomin SP-018

² Kelco to Kelcoloid HVF on sale

Example 53-55

Representative conditioning components for the articles of the invention are prepared in the following manner.

ingredient Example 53 Example 54 Example 55 Minority Awards: Tablets Lecithin ¹ 15.4 10.3 10.8 Deccan 28.6 19.2 15.0 Mineral oil 5.0 Tricontanil PVP ² 26.0 Stearyl alcohol 13.0 12-hydroxystearic acid 19.4 Hydrophilic award: glycerin 28.0 18.8 19.6 Propylene glycol 28.0 18.8 19.6 Active Skin Care Components: Triclosan 0.20 Salicylic acid 0.40 Nicotinamide 4.0

¹ Lucas Meyer to Epikuron 200

² Marketed by ISP as Ganex WP-660

All components are stirred together until a microemulsion is formed. Skin care components are added to the phase that best matches their solubility factor. Upon addition of the wax, it is slowly heated to the melting point of the wax, stirred and dispersed, applied to the substrate or stored at room temperature.

Example 56-58

Representative conditioning components for articles of the invention are prepared according to the following manner.

ingredient Example 56 Example 57 Example 58 Minority Awards: Isohexadecane 42.29 43.0 28.3 Sodium dioctyl sulfosuccinate ² 10.62 7.0 7.1 Hydrophilic award: glycerin 35.17 19.0 23.6 water 11.72 19.0 7.8 Carnauba Wax 29.0 gelatin 6.0 Active Skin Care Components: Triclosan 0.20 Titanium Dioxide for Cosmetics 4.2 Undifferentiated Titanium Dioxide 4.2 Salicylic acid 1.8

¹ Lucas Meyer to Epikuron 2000

² Pfaltz and Bauer available as Aerosol OT

First, skin care components are added to the phase that best matches their solubility factor. Then all the components are stirred together until the microemulsion is formed. Coating on the substrate surface.

Example 59-64

Representative conditioning ingredients for the articles of the invention are prepared in the following manner.

Part A Example 59 Example 60 Example 61 Example 62 Example 63 Example 64 Sodium lauroyl ether sulfate (added with SLES 27% activity) 15.0 6.51 6.20 5.9 Cocamidopropyl Betaine ¹ 13.5 5.85 5.57 5.82 5.19 5.3 Sodium Lauroyl Sarcosinate ² 1.35 0.60 0.57 6.01 5.36 0.54 Decylpolyglucose ³ 5.80 5.18 Lauryl alcohol 1.31 0.56 0.54 0.54 Polyethyleneimine ⁴ 7.87 3.38 3.22 2.64 2.36 3.2 Citric acid (added in 50% aqueous solution) 0.32 0.11 0.11 0.09 Tetrasodium EDTA 0.28 Sulfuric acid 5.4 2.37 2.25 2.2 Preservative, air freshener 0.62 0.45 0.43 2.86 2.55 0.3 Sodium sulfate 7.9 3.47 3.21 3.0 glycerin 26.45 56.7 46.4 44.1 39.36 44.8 Sorbitol 5.0 SEFA ^* Cotonate 12.8 SEFA ^* Behenate 8.0 Part B-Polymer Gelling Agent gelatin 4.2 Polyacrylamide and Isoparaffin ⁵ 7.5 Polyurethane latex in 50% isopropanol ⁶ 34.1 Polyacrylate Copolymer ⁷ 7.5 Polystyrene Sulfonate Copolymer ⁸ 1.1 Chitosan lactate 5.4 Part C-Physical Gelling Agents 12-hydroxystearic acid 10.0 10.66 Stearyl alcohol 10.0 20.0 20.0 7.11 15.0

^* SEFA is an acronym for sucrose esters of fatty acids.

¹ Marketed as Tegobetaine F by Goldschmidt

Commercially available Hamposyl L-30 (type 721), 31% active from ² Hampshire Chemical

³ Henkel sold as Plantaren 2000NP

⁴ Nippon Shokubai Co. Commercially available Epomin SP-018 with molecular weight of about 1800

⁵ BF Goodrich available as Carbopol Ultrez

⁶ BF Goodrich, marketed as Sancure 2710, made from prepolymers containing about 20% polymer, 30% water, and 50% IPA.

⁶ Seppic Corp. Available on Sepigel 305

⁷ marketed as AQ38S by Eastman Chemical

The surfactant and fatty alcohol are combined with a low speed impeller mixer while heating to 65 ° C. Remove heat and allow to cool to 65 ° C. while continuing mixing. Add cationic polymer and stir until homogeneous. The remaining part A is added slowly with stirring. Homogenize to disperse SEFA as an emulsion. Titrate with concentrated sulfuric acid until the pH reaches about 6.5. The Part A composition is spread on a tray and dried in a suitable (vacuum or convection) oven at a temperature not exceeding 65 ° C. until substantially no water remains, to prepare a dry mixture. The dried Part A component is combined with the polymeric gelling agent of Part B and heated to dissolve or disperse. The resulting composition is combined with a physical gelling agent. Heat to melt and dissolve the gelling agent in the composition. Apply to substrate surface (s) or cool to room temperature.

Example 65-70

The following components are used to prepare representative conditioning components for the articles of the present invention as described in Examples 59-64.

Part A Example 65 Example 66 Example 67 Example 68 Example 69 Example 70 Sodium Lauroyl Sarcosinate ¹ 8.87 11.4 10.8 10.8 Polyethyleneimine ² 7.39 7.50 7.50 9.5 9.0 9.0 water 4.43 3.00 3.00 5.7 5.4 5.4 Sulfuric acid 6.36 QS QS 8.1 7.7 7.7 Air freshener, other glycerin 34.45 52.5 45.0 41.3 39.25 34.25 Propylene glycol 2.50 Element 2.50 2.50 2.0 1.9 1.9 Panthenol 2.0 1.9 1.9 Nicotinamide 2.50 2.50 2.0 1.9 1.9 Salicylic acid Polymethylsilsesquioxane ³ 4.20 4.20 Pearlescent mica 3.85 3.85 Stearylmethicone wax 5.0 SEFA Cotonate 5.0 Petrolatum 5.0 Part B-Polymer Gelling Agent gelatin 0.1 Polyacrylamide and Isoparaffin ⁴ 16.0 12.0 12.0 Part C-Physical Gelling Agents 12-hydroxystearic acid 12.0 12.0 10.5 Carnauba Wax 18.0 14.1 14.1 Stearyl alcohol 8.0 8.0 7.0

¹ Marketed as a dry Hamposyl L-95 at Hampshire Chemical

² Nippon Shokubai Co. Commercially available as Epomin SP-018 with molecular weight of about 1800

³ Kobo. Inc. Available from Tospearl 145A

⁴ Seppic Crop. Available on Sepigel 305

Example 71-74

Representative skin conditioning ingredients are prepared comprising the following ingredients.

ingredient Example 71 Example 72 Example 73 Example 74 SEFA ^* Cotonate 62.0 52.0 Petrolatum 4.5 Stearyl alcohol 4.0 Stearic acid 3.0 lanolin 20.0 13.0 Ethylene Vinyl Acetate Polymer ¹ 10.0 10.0 Polydecene ² 2.0 2.0 Sodium Lauroyl Sarcosinate ³ 25.0 3.00 3.0 Lauryl Betaine ⁴ 1.50 2.0 Lauro Ampo Acetate ⁵ 5.25 Sodium Lauret-3 Sulfate ⁶ 10.5 Cocamide MEA ⁷ 2.80 Sulfuric acid QS Guar hydroxypropyltrimonium chloride 0.50 0.50 Cholesterol ⁸ 9.0 1.0 Nonylphenol Polyglycine Ether ⁹ 5.0 Undifferentiated Titanium Dioxide 4.0 Octyl methoxycinnamate 4.0 Nicotinamide 2.5 glycerin 10.0 3.00 water 48.5 55.95 PEG6 Caprylic Acid / Capric Acid Glyceride 3.40 Maleized Soybean Oil 1.50 Deodorized Soybean Oil 8.0 Palm fatty acid 2.60 Polyquaternium-10 0.40 Air freshener, preservative, other 4.60

^* SEFA is an acronym for sucrose esters of fatty acids.

¹ DuPont available as Elvax 40W

² Mobil to Puresyn 3000

³ sold as, for example, Hamposyl L95 (solid) or L30 (30% active in water) by Hampshire Chemical

⁴ marketed by Albright & Wilson as Empigen BS98 (80% Betaine, 20% Salt)

⁵ Available from Albright & Wilson as Empigen CDL60

⁶ Available from Albright & Wilson as Empigen ESC3

⁷ Available from Albright & Wilson as Empigen CME / G

⁸ Croda to Super Hartolan

⁹ Hampshire Chemical Co. Available on Hamplex TNP

The lipid component is melted, water (if applicable) and wetting agent (s) are added and heating and stirring are continued until homogenization is achieved by the addition of a surfactant. Cool to room temperature and add skin care active substance (s) and deposition agent (s). The pH is adjusted to about 7.0 with sulfuric acid. Apply to the substrate by spray, roll, dip or other method and dry (if water is included) before packaging.

III. Personal care supplies

Example 75

Representative skin cleansing articles are made in the following manner.

4 g of the cleansing component of Example 11 is applied to one side of a permeable fusible web comprising low melt heat sealable polyamide fibers. The permeable network is produced by Pellon and produced by H. Levinson & Co. Wonder Under sold by (Chicago, IL). The cleansing ingredients are applied to an oval area of about 13 cm x 18 cm. The cleansing ingredients are air dried. A layer of 2 oz / sq yd polyester batting cut to the same size as the net is placed over the fusible net. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. The nonwoven layer is placed under the fusible net to form the second side of the article. The nonwoven is a spunlace mixture of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive that is hydrated to form a hole of about 2 mm diameter and has a basis weight of about 70 gsm. The shape of the article is an ellipse of about 122 mm x 160 mm. A heat seal mold using a pressure-platen heat seal device such as the Sentinel Model 808 heat sealer available from Sencorp (Hyannis, MA). The layers are sealed together in a grid pattern using point bonds. The point bonds are each measured about 4 mm in diameter, with about 51 individual suture points uniformly distributed. The item can be cleaned and used soon.

Example 76

Representative skin cleansing articles are made in the following manner.

The cleansing component of Example 11 was measured in four lines separated by a distance of 20 mm, 40 mm and 20 mm by measuring the width across the web, so that there was a pair of parallel lines on each side of the net, Continuous extrusion through the coating head is applied to one side of the first substrate. The cleansing component is extruded at a rate such that the cleansing is 4.4 grams of component per finished article. The substrate is a spunlace mixture of 70% rayon and 30% PET fiber bonded with a styrene-butadiene adhesive, hydroapertured to form a hole of about 2 mm diameter and has a basis weight of about 70 gsm. A second net, an air injected lofty low density bet, is continuously infused over the first substrate and placed in contact with the surfactant comprising layer. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. The net is continuously injected with an ultrasonic suture sutured in a dot pattern comprising a lattice of 4 mm diameter suture points uniformly distributed throughout the net. The net is cut into individual articles of about 120 mm × 160 mm rectangular size with rounded corners, with a total of about 51 suture points per article.

Example 77

Representative skin cleansing and conditioning articles are made in the following manner.

Three grams of the skin conditioning composition of Example 34 is applied to each side of the finished article of Example 75 in half. The composition is applied by uniformly coating the composition which is a hot liquid (60-70 ° C.) on the surface of the article and half-coating the composition on each side of the article.

Example 78

Representative skin cleansing and conditioning articles are made in the following manner.

Three grams of the skin conditioning composition of Example 18 is applied to each side of the finished article of Example 75 in half. The composition is applied by uniformly coating the composition which is a hot liquid (60-70 ° C.) on the surface of the article and half-coating the composition on each side of the article.

Example 79

Representative skin cleansing and conditioning articles are made in the following manner.

Three grams of the skin conditioning composition of Example 65 is applied to each side of the finished article of Example 75 in half. The composition is applied by uniformly coating the composition which is a hot liquid (60-70 ° C.) on the surface of the article and half-coating the composition on each side of the article.

Example 80

Representative skin cleansing and conditioning articles are made in the following manner.

Three grams of the skin conditioning composition of Example 34 is applied to each side of the finished article of Example 76 in half. The composition is applied by uniformly coating the composition which is a hot liquid (60-70 ° C.) on the surface of the article and half-coating the composition on each side of the article.

Example 81

Representative skin cleansing and conditioning articles are made in the following manner.

Three grams of the skin conditioning composition of Example 18 is applied to each side of the finished article of Example 76 in half. The composition is applied by uniformly coating the composition which is a hot liquid (60-70 ° C.) on the surface of the article and half-coating the composition on each side of the article.

Example 82

Representative skin cleansing and conditioning articles are made in the following manner.

Three grams of the skin conditioning composition of Example 65 is applied to each side of the finished article of Example 76 in half. The composition is applied by uniformly coating the composition which is a hot liquid (60-70 ° C.) on the surface of the article and half-coating the composition on each side of the article.

Example 83

Representative skin cleansing articles are made in the following manner.

The coating head of Example 11 was measured with four lines separated by distances of 20 mm, 40 mm and 20 mm, measuring the width across the net, with a pair of parallel lines on each side of the net. It is continuously extruded through and applied to one side of the first substrate. The cleansing component is extruded at a rate such that the cleansing component is 4.4 grams per finished article. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. A second net, an air injected lofty low density bet, is continuously infused over the first substrate and placed in contact with the surfactant comprising layer. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. The net is continuously injected with an ultrasonic suture sutured in a dot pattern comprising a lattice of 4 mm diameter suture points uniformly distributed throughout the net. The net is cut into individual articles of about 120 mm x 480 mm rectangular size with rounded corners.

Example 84

Representative skin cleansing articles are made in the following manner.

The coating head of Example 11 was measured with four lines separated by distances of 20 mm, 40 mm and 20 mm, measuring the width across the net, with a pair of parallel lines on each side of the net. Continuous extrusion through to apply to one side of the first substrate. The cleansing component is extruded at a rate such that the cleansing component is 4.4 grams per finished article. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. A second substrate net, an air injected lofty low density bet, is continuously infused over the first substrate and placed in contact with the surfactant comprising layer. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. A third substrate network identical to the second substrate network is continuously infused over the second substrate network and placed in contact with the second substrate. The net is continuously injected with an ultrasonic suture sutured in a dot pattern comprising a lattice of 4 mm diameter suture points uniformly distributed throughout the net. The net is cut into individual articles of about 120 mm x 90 mm rectangular size with rounded corners.

Example 85

Representative skin cleansing articles are made in the following manner.

Four grams of the cleansing component of Example 12 is applied to one side of a permeable fusible net comprising low melt heat sealable polyamide fibers. The permeable network is produced by Pellon and produced by H. Levinson & Co. Wonder Under sold by (Chicago, IL). The cleansing ingredients are applied to an oval area of about 13 cm x 18 cm. The cleansing ingredients are air dried. A layer of 2 oz / sq yd polyester batting cut to the same size as the net is placed over the fusible net. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The batting has an air permeability of about 1270 cfm / ft ² and a foam permeable crystal pressure of about 2.7 cm H ₂ O. Betting is considered to be thermally bonded without the use of adhesives. The nonwoven layer is placed under the fusible net to form the second side of the article. The nonwoven is a spunlace mixture of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive that is hydrated to form a hole of about 2 mm diameter and has a basis weight of about 70 gsm. The shape of the article is an ellipse of about 122 mm x 160 mm. A heat seal mold using a pressure-platen heat seal device such as the Sentinel Model 808 heat sealer available from Sencorp (Hyannis, MA). The layers are sealed together in a grid pattern using point bonds. The point bonds are each measured about 4 mm in diameter, with about 51 individual suture points uniformly distributed. The item can be cleaned and used soon.

Examples 86-88

With the cleansing components of Examples 1, 2 and 5, a representative skin cleansing article is prepared in the following manner.

A permeable, fusible mesh comprising 8 grams of cleansing components containing low melt heat-sealing fibers, with four quadrants forming a rectangle approximately 10 inches by 12 inches, leaving a space between the edge and quadrant so that the layer is sealed without surfactant. Apply to one side of Permeable nets are fibrous low density polyethylene (LDPE or LLDPE) materials commercially available from sewing suppliers. A layer of 4 oz / sq yd polyester batting cut to the same size as the net is placed over the fusible net. The polyester batting has a basis weight of 4 oz / yd ² and consists of polyester fibers with an average diameter of about 30 microns and is bonded with an adhesive, for example Mountain Mist Extra Heavy Batting # 205 at Stearns Textiles (Cincinnati, OH). Is sold. A fibrous nonwoven layer having a basis weight of about 65 gsm and a hydrated weaving mixture of 55% cellulose and 45% polyester (commercially available as Technicloth II from The Texwipe Company (Saddle River, NJ)) under the fusible mesh Let's do it. Heat sealing molds using pressure plate heat sealing devices such as the Sentinel Model 808 heat sealer sold by Sencorp (Hyannis, MA), which are rectangular at a temperature and pressure sufficient to melt the bets and flow into the first layer to form a suitable seal. The layers are sealed together in the form of a pane, usually about 370 degrees Fahrenheit and 30 psi mechanical seals are sufficient for 6-10 seconds. The sutures are continuous around the edges and have a single pane cross circle that is about 2 mm wide in each X- and Y-direction. After cooling, the items are trimmed and rounded in corners and stored until use.

Examples 89-90

With the cleansing ingredient powders of Examples 3 and 4, representative skin cleansing and conditioning articles are prepared in the following manner.

Four grams of dry cleansing ingredient powder is applied to one side of a permeable fusible net comprising low melt heat sealable fibers. The permeable network is produced by Pellon and produced by H. Levinson & Co. Wonder Under sold by (Chicago, IL). The powder is evenly sprayed on an ellipse site of about 17 cm x 19 cm. A layer of 2 oz / sq yd polyester batting cut to the same size as the net is placed over the fusible net. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The batting has an air permeability of about 1270 cfm / ft ² and a foam permeable crystal pressure of about 2.7 cm H ₂ O. Betting is considered to be thermally bonded without the use of adhesives. A second nonwoven layer is prepared that includes hydrated, polyester fibers about 10 microns in diameter, and interlaced polypropylene scrims having a fiber diameter of about 150 microns and woven about 0.8 cm apart. The second layer is cut larger than the required article axis so that the X- and Y-axes of the layer are reduced to about 70 percent of their original size, and the layer is about 0.12 in. Measured at 5 gsi. Place in a convection oven for about 10 minutes at a temperature of about 150 degrees Celsius until it has a macroscopic thickness of. The layer has perforations showing a macroscopic mean basis weight of about 64 gsm and an average diameter of about 0.5 mm before shrinking. Place the second layer underneath the fusible net, seal the layers together with point bonds, and also round the perimeter with a heat seal mold using a pressure plate heat seal device such as the Sentinel Model 808 heat sealer available from Sencorp (Hyannis, MA). Suture about 2 mm wide. The point bonds each have a diameter of about 3 mm and about 51 individual suture points are evenly distributed. The article is groomed and the composition is injected through an injection reservoir maintained at about 60 ° C. and a slotted rolling device having a mechanized 1.5 mm gap to apply 2.5 grams of the skin conditioning composition of Example 25 to the lofty batting side of the article. . The composition is rapidly cooled on the article surface and stored in a sealed metallized film package until use.

Examples 91-96

With the liquid cleansing ingredients of Examples 6, 8, 9, 15, 16 and 17, representative skin cleansing and conditioning articles are prepared in the following manner.

The liquid cleansing component is coated with a brush in the form of a windowpane excluding the edge and the suture position until 2 grams of the solid cleansing component is applied and applied to one side of the first substrate. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. The substrate is air dried in a convection oven at 45 ° C. for about 6 hours or until touched. A second substrate, an air injected lofty low density bet, is placed on the first substrate and placed in contact with the surfactant comprising layer. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. Heat sealing molds using pressure plate heat sealing devices such as the Sentinel Model 808 heat sealer sold by Sencorp (Hyannis, MA), which are rectangular at a temperature and pressure sufficient to melt the bets and flow into the first layer to form a suitable seal. The layers are sealed together in the form of a windowpane, usually about 370 degrees Fahrenheit and 30 psi mechanical seals are sufficient for 6-10 seconds. The sutures are continuous around the edges and have a single pane cross circle that is about 2 mm wide in each of the X- and Y-directions. After cooling, the article was groomed and the composition was injected through an injection reservoir maintained at about 60 ° C. and a slotted rolling device having a mechanized 1.5 mm gap, so that 3 grams of the skin conditioning composition of Example 26 was applied to the lofty batting side of the article. Apply. The composition is rapidly cooled on the article surface and stored in a sealed metallized film package until use.

Examples 97-102

With the liquid cleansing component of Example 7 and the skin conditioning composition of Examples 19 to 24, a representative skin cleansing and conditioning article is prepared in the following manner.

Four strips of liquid cleansing components are continuously extruded onto a mobile first network which is an lofted low density bet that is air injected. The polyester batting has a basis weight of 2 oz / yd ² and comprises a fiber mixture of about 23 microns and 40 microns average diameter, with at least a portion of them being corrugated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. The liquid cleansing component is heated to the melting point, stored in a reservoir at about 65 ° C., and pumped into an extrusion head for continuous metering of four cylindrical strands on the network with a uniform distance across the network, yielding about 5 grams of the composition per finished article. To get the final addition rate. A second net, a film in microperforated and macroperforated form, a film formed in US Pat. No. 4,629,643, is continuously injected onto the macroporous protruding side toward the batting and cleansing component on the first net. The skin conditioning composition is uniformly slot coated onto the exposed batting surface in the hot state at a rate of about 3 grams of composition per finished article, and cooled and solidified on the article surface. The nets are sutured continuously and cut into rounded corners of about 120 mm x 160 mm rectangles using heated metal rolls and pressure rolls applied to the forming film side. Pack the goods until use.

Examples 103-105

With the liquid cleansing component of Example 6 and the skin conditioning composition of Examples 56, 57 and 58, a representative skin cleansing and conditioning article is prepared in the following manner.

The liquid cleansing component is coated with a brush in the form of a windowpane excluding the edge and the suture position until 2 grams of solid surfactant is applied and applied to one side of the first substrate. The substrate is a polyester batting having a basis weight of 2 oz / yd ² and comprises a mixture of about 23 micron and 40 micron average diameter fibers, some of which are corrugated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. Dry the cleansing ingredients. A second substrate, a high humidity strength, adhesively bonded cellulose paper towel having a good loft and a basis weight of about 53 gsm, is placed over the exposed side of the betting cleansing component. Useful towels are manufactured by The Procter & Gamble Company and Bounty Rinse & Reuse, which retain their Z-direction height when wet and have a thickness of about 0.047 inches at 5 gsi and a loft / soft ratio of about 1.28. To be sold. Heat seal molds using pressure plate heat seal devices such as the Sentinel Model 808 heat sealer available from Sencorp (Hyannis, MA), which seal the layers together in a rectangular windowpane at a temperature and pressure sufficient to form a suitable seal. Continuously sutured around the edges, it has a single pane cross circle that is about 2 mm wide in each of the X- and Y-directions. The article is trimmed and the composition is injected through an injection reservoir maintained at about 60 ° C. and a slotted rolling device having a mechanized 1.5 mm gap to apply 1.5 grams of skin conditioning composition to the lofty batting side of the article. The composition is rapidly cooled on the article surface and stored in a sealed metallized film package until use.

Example 106

Representative skin cleansing and conditioning articles are made in the following manner.

The cleansing component of Example 12 was measured through a coating head, measuring the width across the net, with four separate lines each separated by a distance of 20 mm, 40 mm and 20 mm, with a pair of parallel lines on each side of the net. Continuous extrusion is applied to one side of the first substrate. The cleansing component is extruded at a rate such that the cleansing component is 4.4 grams per finished article. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. A second substrate network, an air injected lofty low density bet, is continuously infused over the first substrate and placed in contact with the surfactant layer. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. A third substrate network identical to the second substrate network is continuously infused over the second substrate network and placed in contact with the second substrate. The net is continuously injected with an ultrasonic suture sutured in a dot pattern comprising a lattice of 4 mm diameter suture points uniformly distributed throughout the net. The skin conditioning liquid of Example 53 is sprayed onto the network at a rate of about 25 gsm per side or about 0.5 grams of the composition per finished article. The net is cut into individual articles of about 120 mm x 90 mm rectangular size with rounded corners and packaged until use.

Examples 107-108

Using the skin conditioning compositions of Examples 54 and 55, representative skin cleansing and conditioning articles are prepared in the following manner.

The low water activity cleansing component of Example 2 was prepared using aluminosilicate (which generates heat due to exothermic reactions when exposed to water and is commercially available as Advera 401 N from The PQ Corporation (Valley Forge, PA)). Grind into three rolls in a ratio of 1: 1. Ten grams of cleansing ingredients are applied to one side of the batting layer. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. The surfactant is applied to the fibers in four quadrants forming a rectangle of about 10 inches by 12 inches, leaving a space between the edge and quadrant so that the layer is sealed without surfactant. Weaved (bonded) with a fiber diameter that is hydrated and comprises polyester fibers of about 10 microns diameter and has a fiber diameter therein that is about 100 microns across the nonwoven width and about 250 microns perpendicular to the width A second nonwoven layer is prepared comprising an interlaced scrim. The scrim is commercially available from Conwed plastics (Minneapolis, MN). The second nonwoven has a basis weight of about 70 gsm and is slightly crumpled due to relaxation of the mesh stretch and subsequent stretch during the manufacture of the nonwoven. The layer is closed about 2 mm wide with a point bond and a heat seal mold using a pressure plate heat seal device such as the Sentinel Model 808 heat sealer available from Sencorp (Hyannis, Mass.). The point bonds each have a diameter of about 3 mm and about 51 individual sutures are distributed evenly. The article is groomed and the composition is injected through an injection reservoir maintained at about 60 ° C. and a slotted rolling device having a mechanized 1.5 mm gap to apply 4 grams of skin conditioning composition to the lofty batting side of the article. The composition is rapidly cooled on the article surface and stored in a sealed metallized film package until use.

Examples 109-116

Using skin conditioning compositions of Examples 59, 60, 61, 62, 63, 68, 69 and 70, representative skin cleansing and conditioning articles are prepared in the following manner.

Four grams of the cleansing ingredients of Example 11 are evenly sprayed by hand over the lofty bets. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. It has a basis weight of about 65 gsm and is coated with a cleansing component of the batting, a fibrous nonwoven layer of 55% cellulose and 45% polyester (commercially available as Technicloth II from Texwipe Company (Saddle River, NJ)). Lay across. The layers are stitched together using a peristaltic suture plate using an unheated plate having an inverted thimble shaped reservoir uniformly distributed in a hexagonal grid pattern. The thimble reservoirs are about 1.2 cm in diameter at the base and about 2 cm apart from the center-center. Land portions between the dimples on the non-heating plate are concave to several millimeters inward to form troughs connected to each other. The heating plate has an external ridge that exactly fits into the valleys on the land portion of the unheated plate. The heating plate is in contact with the cellulose / polyester substrate and heat sealed using a pressure plate heat seal device such as the Sentinel Model 808 heat sealer available from Sencorp (Hyannis, MA). The resulting unfinished article has a pronounced thimble shape with raised batting sides and shorter dimples or “buttons” with raised cellulose / polyester substrate sides of the article, both sides being easy to grab. The article is cut into about 120 mm x 160 mm rectangles. Three grams of skin conditioning composition per article is pipetted into the fracture area while the composition is hot to cool and solidify. Pack the goods until use.

Example 117

Representative skin cleansing and conditioning articles are made in the following manner.

Example 4 Eight grams of liquid cleansing component of the cleansing component, with four quadrants forming a rectangle of about 10 inches by 12 inches, leaving a space between the edge and quadrant so that the layer is sealed without surfactants. It is applied to one side of a permeable fusing net comprising a. Permeable nets are fibrous low density polyethylene (LDPE or LLDPE) materials commercially available from sewing suppliers. Dry the composition. A layer of 4 oz / sq yd polyester batting cut to the same size as the net is placed over the fusible net. The polyester batting has a basis weight of 4 oz / yd ² and consists of polyester fibers of about 30 micron average diameter and is bonded with an adhesive, for example Mountain Mist Extra Heavy Batting # 205 at Stearns Textiles (Cincinnati, OH). Is sold. A fibrous nonwoven layer having a basis weight of about 65 gsm and a hydrated weaving mixture of 55% cellulose and 45% polyester (commercially available as Technicloth II from Texwipe Company (Saddle River, NJ)) is placed under the fusible net. Heat sealing molds using pressure plate heat sealing devices such as the Sentinel Model 808 heat sealer sold by Sencorp (Hyannis, MA), which are rectangular at a temperature and pressure sufficient to melt the bets and flow into the first layer to form a suitable seal. The layers are sealed together in the form of a pane, usually about 370 degrees Fahrenheit and 30 psi mechanical seals are sufficient for 6-10 seconds. The sutures are continuous around the edges and have a single pane cross circle that is about 2 mm wide in each of the X- and Y-directions. Five grams of the conditioning composition of Example 64 is applied with a brush in half on each side of the article and the article is dried again. Trim the items and round the corners and store until use.

Examples 118-119

Using the skin cleansing compositions of Examples 66 and 67, representative skin cleansing and conditioning articles are prepared in the following manner.

The 120 mm × 160 mm cut surface of the substrate is immersed in the composition container until its weight increases to about 8 grams to apply the liquid cleansing component of Example 15 to the first substrate. The substrate is a silver batting polyester having a basis weight of 2 oz / yd ² , comprising a fiber mixture of about 23 microns and 40 microns average diameter, with at least a portion of them being corrugated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. Dry the substrate. A spunlace mixture of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, which is hydrated to form a piece of a second substrate having a hole of about 2 mm diameter and having a basis weight of about 70 gsm. Lay on. The substrates are stitched together using an ultrasonic suture that sutures in a dot pattern comprising a lattice of 4 mm diameter suture points uniformly distributed throughout the article. The composition is injected through an injection reservoir maintained at about 60 ° C. and a slotted rolling device with a mechanized 1.5 mm gap to apply 4 grams of skin conditioning composition uniformly across both sides of the article. The composition is rapidly cooled on the article surface and stored in a sealed metallized film package until use.

Examples 120-124

Using the skin conditioning compositions of Examples 27-31, representative skin cleansing and conditioning articles are prepared in the following manner.

The coating head of Example 11 was measured with four lines separated by distances of 20 mm, 40 mm and 20 mm, measuring the width across the net, with a pair of parallel lines on each side of the net. Continuous extrusion through to apply to one side of the first substrate. The cleansing component is extruded at a rate such that the cleansing component is 4.4 grams per finished article. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. A second substrate network, an air injected lofty low density polyester batting, is continuously infused over the first substrate and placed in contact with the surfactant comprising layer. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. A third substrate network identical to the second substrate network is continuously infused over the second substrate network and placed in contact with the second substrate. The net is continuously injected with an ultrasonic suture sutured in a dot pattern comprising a lattice of 4 mm diameter suture points uniformly distributed throughout the net. From the hot reservoir pumped through the slot dye, slot coating the skin conditioning composition on both sides of the substrate (added about 140 gsm per side) at the same rate as 3 grams of the skin conditioning composition per finished article, and the composition is external to the article. Pass the cooling fan to cool rapidly on the surface. The net is cut into individual articles of about 120 mm x 90 mm rectangular size with rounded corners.

Examples 125-145

Using skin conditioning compositions of Examples 32-52, representative skin cleansing and conditioning articles are prepared in the following manner.

The coating head of Example 11 was measured with four lines separated by distances of 20 mm, 40 mm and 20 mm, measuring the width across the net, with a pair of parallel lines on each side of the net. Continuous extrusion through to apply to one side of the first substrate. The cleansing component is extruded at a rate such that the cleansing component is 4.4 grams per finished article. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. A second substrate net, an air injected lofty low density bet, is continuously infused over the first substrate and placed in contact with the surfactant comprising layer. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. A third substrate network identical to the second substrate network is continuously injected over the second substrate and placed in contact with the second substrate. The net is continuously injected with an ultrasonic suture sutured in a dot pattern comprising a lattice of 4 mm diameter suture points uniformly distributed throughout the net. From the hot reservoir pumped through the slot dye, slot coating the skin conditioning composition on both sides of the substrate (added about 140 gsm per side) at the same rate as 3 grams of the skin conditioning composition per finished article, and the composition is external to the article. Pass the cooling fan to cool rapidly on the surface. The slot coating reservoirs are continuously mixed to maintain the stability of the emulsion. The net is cut into individual articles of about 120 mm x 90 mm rectangular size with rounded corners.

Examples 146-147

Using the skin cleansing and conditioning compositions of Examples 71 and 74, representative skin cleansing and conditioning articles are prepared in the following manner.

The first and second substrates are cut into about 12 inch by 9 inch rectangles. The first substrate is a spunlace mixture of 70% rayon and 30% PET fiber bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. The second substrate is a polyester batting having a basis weight of 2 oz / yd ² , comprising a fiber mixture of about 23 microns and 40 microns average diameter, at least a portion of which is corrugated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. Heat sealing molds using pressure plate heat sealing devices such as the Sentinel Model 808 heat sealer sold by Sencorp (Hyannis, MA), which are rectangular at a temperature and pressure sufficient to melt the bets and flow into the first layer to form a suitable seal. The substrates are sealed together in the form of a pane, usually about 370 degrees Fahrenheit and 30 psi mechanical seals are sufficient for 6-10 seconds. The sutures are continuous around the edges and have a single pane cross circle that is about 2 mm wide in each of the X- and Y-directions. After cooling the article is trimmed to about 11 inches by 8.5 inches, and 10 grams of skin cleansing and conditioning composition is brushed on both sides of the outer surface, about half of the composition per side. The composition is dried and stored until use.

Examples 148-149

Using the skin cleansing and conditioning compositions of Examples 72 and 73, representative skin cleansing and conditioning articles are prepared in the following manner.

The first and second substrates are cut into rectangles of about 12 inches by 9 inches. The first substrate is a spunlace mixture of 70% rayon and 30% PET fiber bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. The second substrate is a polyester batting having a basis weight of 2 oz / yd ² , comprising a fiber mixture of about 23 microns and 40 microns average diameter, wherein at least a portion of the polyester batting is corrugated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. Heat sealing molds using pressure plate heat sealing devices such as the Sentinel Model 808 heat sealer sold by Sencorp (Hyannis, MA), which are rectangular at a temperature and pressure sufficient to melt the bets and flow into the first layer to form a suitable seal. The substrates are sealed together in the form of a pane, usually about 370 degrees Fahrenheit and 30 psi mechanical seals are sufficient for 6-10 seconds. The sutures are continuous around the edges and have a single pane cross circle that is about 2 mm wide in each of the X- and Y-directions. After cooling, the article is trimmed to about 11 inches by 8.5 inches, and 8 grams of skin cleansing and conditioning composition is maintained at about 70 ° C., a motorized XY coordinate for a heated reservoir, pump, on-off valve, slot head, and coating head. A XY table, a programmable adjustment metrology system including an adjustment system, is used to slot coat the article on each article, 4 grams per side, to distribute evenly on the article surface. The composition cools rapidly on the surface of the article. Pack the goods until use.

Examples 150-152

Representative skin cleansing and conditioning articles are made in the following manner.

A liquid cleansing ingredient is prepared comprising the following ingredients:

ingredient Example 150 Example 151 Example 152 Sodium Lauret 3 Sulfate 3.60 Sodium C13 / C14 Methyl Side Chain Sulfate 5.00 5.60 4.50 Sodium paraffin sulfonate 6.40 Sodium alpha olefin sulfonate 5.20 Sodium Lauryl Sulfate 5.50 Sodium Lauro Ampo Acetate 4.50 5.30 3.65 Cocamide MEA 3.55 3.20 2.80 Succinic acid 2.80 5.70 6.00 Sodium succinate 0.10 0.14 0.30 Citric acid 3.00 4.30 5.00 Sodium citrate 1.60 1.10 1.40 Malonic acid 4.00 2.20 glycerin 10.00 15.00 8.50 Coconut 12-18 fatty acid 2.00 3.00 Spices 1.00 1.20 1.00 MgSO ₄ -7H ₂ O 0.89 0.90 0.80 water 54.21 47.61 52.25 Salicylic acid 1.85 Triclosan 0.25 Trichlorocarbanilide 1.10 Zinc pyrithione 2.00

The cleansing component is brushed on one side of the substrate and applied to one side of the first substrate until 10 grams of the composition is added to the 11 inch by 8.5 inch cut plane. The substrate is a polyester batting having a basis weight of 2 oz / yd ² , comprising a fiber mixture of about 23 microns and 40 microns average diameter, at least a portion of which is corrugated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. Dry the first substrate. The second substrate is thinned onto the untreated side of the first substrate using an ultrasonic suture that sutures in a dot pattern that includes a grid of 4 mm diameter suture points uniformly distributed at 2 cm intervals across the network. The second substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with styrene-butadiene adhesive, which is hydrated to form a hole of about 2 mm diameter and has a basis weight of about 70 gsm. The skin conditioning composition of Example 19 is uniformly slot coated and cooled on the entire surface of the second substrate at a rate of about 3 grams of composition per article, and packaged until use. The article is endowed with sustained antiviral, antifungal, and antibacterial activity against Gram negative and Gram positive microorganisms, foams well, and is relatively mild to the skin.

Example 153

Representative skin cleansing and conditioning articles are made in the following manner.

Four grams of the cleansing ingredients of Example 11 are evenly sprayed by hand over the lofty bets. The bet is a 4 oz / sq yd polyester batting comprising polyester fibers with an average diameter of about 30 microns, cut to 130 mm x 175 mm and bonded with an adhesive, for example Stearns Textiles (Cincinnati, OH) Available as Mountain Mist Extra Heavy Batting # 205. A fibrous nonwoven layer having a basis weight of about 65 gsm and a hydrated weaving mixture of 55% cellulose and 45% polyester (commercially available as Technicloth II from Texwipe Company (Saddle River, NJ)) was applied to the surfactant coating side of the batting. Lay on. The layers are stitched together using an interlocking suture plate using an unheated plate having an inverted thimble shape reservoir uniformly distributed in a hexagonal grid pattern. The thimble reservoirs are about 1.2 cm in diameter at the base and about 1.5 cm apart from the center-center. Land portions between the dimples on the unheated plate look upwards a few mm to form ridges that are connected to each other. The heating plate has external fractures that exactly fit into the ridges of the unheated plate. The heating plate is in contact with the cellulose / polyester substrate and heat sealed using a pressure plate heat seal device such as the Sentinel Model 808 heat sealer available from Sencorp (Hyannis, MA). The resulting unfinished article has a three-dimensional feature on both sides that facilitates foaming and is easy to grab during use and slip along the skin surface. The article is cut into about 120 mm x 160 mm rectangles.

Skin Conditioning Inverse Emulsion Paste for use with the article is prepared as follows:

ingredient percent PEG 30-dipolyhydroxystearate 3.0 SEFA Cotonate 20.0 Petrolatum 4.0 Tribehenin 5.0 C10-C30 Cholesterol / Lanosterol Ester 13.0 SEFA Behenate 5.0 glycerin 50.0

The fat soluble component is heated to 70 ° C. with stirring. Add glycerin slowly with vigorous stirring. Homogenize the composition. Three grams of skin conditioning inverse emulsion paste is pipetted hot into the pressed area on the cellulose / polyester side of the article. The composition is quickly cooled to a semisolid paste. Pack the goods until use.

Examples 154-158

Using the skin conditioning compositions of Examples 19, 29, 34, 55 and 60, representative skin conditioning articles are prepared in the following manner.

The conditioning composition is coated with a pair of parallel lines on each side of the net, with 4 lines each 5 mm wide and measuring the width across the net, each separated by a distance of 20 mm, 40 mm and 20 mm. Continuous extrusion through the head is applied to one side of the first substrate. The composition is extruded at a rate such that the composition has 3 grams per finished article. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. A second net, an air injected lofty low density bet, is continuously infused over the first substrate and placed in contact with the first substrate on the side that does not contain the skin conditioning composition. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. The net is continuously injected with an ultrasonic suture sutured in a dot pattern comprising a lattice of 4 mm diameter suture points uniformly distributed throughout the net. The net is cut into individual articles of about 120 mm × 160 mm rectangular size with rounded corners having a total of about 51 suture points per article.

Examples 159-163

Using the skin conditioning compositions of Examples 19, 28, 34, 55 and 69, representative skin conditioning articles are prepared in the following manner.

The conditioning composition is coated with a pair of parallel lines on each side of the net, with 4 lines each 5 mm wide and measuring the width across the net, each separated by a distance of 20 mm, 40 mm and 20 mm. Continuous extrusion through the head is applied to one side of the first substrate. The composition is extruded at a rate such that the composition has 1.1 grams per finished article. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. A second net, an air injected lofty low density bet, is continuously infused over the first substrate and placed in contact with the first substrate on the side that does not contain the skin conditioning composition. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. The net is continuously injected with an ultrasonic suture sutured in a dot pattern comprising a lattice of 4 mm diameter suture points uniformly distributed throughout the net. The net is cut into individual articles of about 120 mm x 90 mm rectangular size with rounded corners, with a total of about 51 suture points per article. The article is convenient to apply to narrower areas of the skin, such as the face, elbows, necks and / or feet.

Example 164

Representative skin cleansing articles are made in the following manner.

The coating head of Example 11 was measured with four lines separated by distances of 20 mm, 40 mm and 20 mm, measuring the width across the net, with a pair of parallel lines on each side of the net. Continuous extrusion through to apply to one side of the first substrate. The cleansing component is extruded at a rate such that the cleansing component is 0.40 grams per finished article. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. A second substrate network, an air injected lofty low density bet, is continuously infused over the first substrate and placed in contact with the surfactant layer. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. A third substrate network identical to the second substrate network is continuously infused over the second substrate network and placed in contact with the second substrate. The net is continuously injected with an ultrasonic suture sutured in a dot pattern comprising a lattice of 4 mm diameter suture points uniformly distributed throughout the net. The net is cut into individual articles of about 120 mm x 90 mm rectangular size with rounded corners.

Examples 165-169

Using the skin conditioning compositions of Examples 19, 28, 34, 55 and 69, representative skin cleansing and conditioning articles are prepared in the following manner.

The coating head of Example 11 was measured with four lines separated by distances of 20 mm, 40 mm and 20 mm, measuring the width across the net, with a pair of parallel lines on each side of the net. Continuous extrusion through to apply to one side of the first substrate. The cleansing component is extruded at a rate such that the cleansing component is 0.52 grams per finished article. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. A second substrate network, an air injected lofty low density bet, is continuously infused over the first substrate and placed in contact with the surfactant layer. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. A third substrate network identical to the second substrate network is continuously infused over the second substrate network and placed in contact with the second substrate. The net is continuously injected with an ultrasonic suture sutured in a dot pattern comprising a lattice of 4 mm diameter suture points uniformly distributed throughout the net. From the hot reservoir pumped through the slot dye, slot coating the skin conditioning composition on both sides of the substrate (added about 55 gsm per side) at a rate equal to 1.25 grams of the skin conditioning composition per finished article, and the composition is external to the article. Pass the cooling fan to cool rapidly on the surface. Cut the net into individual articles about 120 mm x 90 mm rectangular with rounded corners.

Example 170

Representative skin cleansing and conditioning kits are prepared in the following manner.

Prepare a skin cleansing article. The coating head of Example 11 was measured with four lines separated by distances of 20 mm, 40 mm and 20 mm, measuring the width across the net, with a pair of parallel lines on each side of the net. Continuous extrusion through to apply to one side of the first substrate. The cleansing component is extruded at a rate such that the cleansing component is 4.4 grams per finished article. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. A second net, an air injected lofty low density bet, is continuously infused over the first substrate and placed in contact with the surfactant comprising layer. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. The net is continuously injected with an ultrasonic suture sutured in a dot pattern comprising a lattice of 4 mm diameter suture points uniformly distributed throughout the net. The net is cut into individual articles of about 120 mm x 480 mm rectangular size with rounded corners.

Prepare a skin conditioning article. The conditioning composition of Example 34 was each 5 mm wide, measuring the width across the net, with four lines each separated by a distance of 20 mm, 40 mm and 20 mm, with a pair of parallel lines on each side of the net. If possible, continuous extrusion through the coating head is applied to one side of the first substrate. The composition is extruded at a rate such that the composition has 3 grams per finished article. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. A second net, an air injected lofty low density bet, is continuously infused over the first substrate and placed in contact with the first substrate on the side that does not contain the skin conditioning composition. The batting comprises a mixture of 30% 15 denier PET fibers, 35% 3 denier bicomponent fibers with PET core and PE sheet and 35% 10 denier bicomponent fibers of the same core-sheet composition, about per square meter Has a basis weight of 100 grams (gsm). The net is continuously injected with an ultrasonic suture sutured in a dot pattern comprising a lattice of 4 mm diameter suture points uniformly distributed throughout the net. The net is cut into individual articles of about 120 mm × 160 mm rectangular size with rounded corners, with a total of about 51 suture points per article.

Skin cleansing articles and skin conditioning articles are packaged together in a single package.

Example 171

Representative skin cleansing and conditioning kits are prepared in the following manner.

Prepare a skin cleansing article. The coating head of Example 11 was measured with four lines separated by 20 mm, 40 mm and 20 mm distances, respectively, by measuring the width across the net, so that there was a pair of parallel lines on each side of the net. Continuous extrusion through to apply to one side of the first substrate. The cleansing component is extruded at a rate such that the cleansing component is 4.4 grams per finished article. The substrate is a spunlace mixture of 70% rayon and 30% PET fibers bonded with styrene-butadiene adhesive, hydrated to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm. A second net, an air injected lofty low density bet, is continuously infused over the first substrate and placed in contact with the surfactant layer. The polyester batting has a basis weight of 2 oz / yd ² , comprises a fiber mixture of about 23 microns and 40 microns average diameter, and at least some of which are pleated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The bets are considered thermally bonded without the use of adhesives and have a total scratch cover of about 22%. The net is continuously injected with an ultrasonic suture sutured in a dot pattern comprising a lattice of 4 mm diameter suture points uniformly distributed throughout the net. The net is cut into individual articles of about 120 mm x 480 mm rectangular size with rounded corners.

Prepare a skin conditioning article. A substrate is produced that is a hydrated weaving mixture of fibers, with softer and finer denier fibers on one side and coarser fibers on the other side. Substrates are prepared by affixing two nets, each having a basis weight of about 20 gsm and comprising 10 denier polyester (PET) fibers, one web on top of the other. A mesh of polypropylene scrim with a diameter of about 100 microns and woven about 0.8 cm apart is injected over the fibrous network as a third network. Fourth and fifth webs comprising 3 denier polyester fibers are each air-adhered at about 20 gsm on top of the webs. The nets are hydrated to fix them into a single net unit and dried on a drying can until moisture is removed and about 20% shrinkage due to relaxation of the scrim occurs. By kiss roll application at a wet addition rate of about 7 gsm, a low T _g (about 5 ° C.) waterborne acrylic adhesive copolymer is added to the coarse fiber side of the net and dried. The skin conditioning composition of Example 21 is continuously added to the net by slot coating the composition uniformly across both sides of the net at a rate of about 25 gsm per side. The substrate network is cut into individual articles of about 120 mm x 100 mm rectangular size with rounded corners using a hot cutting roll that causes the scrim fibers to shrink slightly from the edge of the article when cut.

Skin cleansing articles and skin conditioning articles are packaged together in a single package.

Example 172

Representative skin cleansing and conditioning articles are made in the following manner.

Prepare the first side. A polyester batting having a basis weight of 2 oz / yd ² produces a first layer of the first side, comprising a fiber mixture of about 23 microns and 40 microns average diameter, at least a portion of which is corrugated. The thickness of the bet is approximately 0.23 in. Measured at 5 gsi. to be. The batting has an air permeability of about 1270 cfm / ft ² and a foam permeable crystal pressure of about 2.7 cm H ₂ O. Betting is considered to be thermally bonded without the use of adhesives. Cut the bet to 10 square inches. A second layer of the first side, which is a 10 square inch sheet of microperforated 100 mesh formed film made by forming a hydration perforation at high pressure on a drum comprising a 100 mesh forming screen, is prepared (eg, US Pat. No. 4,629,643). As disclosed in). The sheet is placed on the first layer with the protruding surface facing up. 25 grams of the skin cleansing composition of Example 1 is centered on the first side. The composition is slightly flattened to a shape that is about 1/2 inch thick and a few inches diameter. A layer of impermeable polyethylene film having a 10 square inch dimension identically to the first layer is laid over the composition. 25 grams of the skin conditioning composition of Example 63 are shaped the same as the cleansing composition and placed on top of the film at the same xy position as the surfactant. The microperforated and macroperforated molded film layers (also disclosed in US Pat. No. 4,629,643) are placed with the protruding side of the macroperforation facing the composition and the protruding side of the microperforating facing up. Also cut the layer into 10 square inches. A final layer is prepared which is a hydrated weaving mixture of fibers with soft and fine denier fibers. Layers are prepared by two meshes, each having a basis weight of about 17 gsm and comprising 3 denier polyester (PET) fibers, one layer of air on top of the other. Continuous injection of a mesh of elastomeric scrim comprising a fiber of about 100 microns diameter in one direction, woven with fibers of about 40 microns diameter in the other direction, woven at about 0.1 cm intervals, over a fibrous network as a third network do. The net is commercially available from Conwed Plastics (Minneapolis, MN). Fourth and fifth webs comprising 3 denier polyester fibers are each air-attached at about 17 gsm on top of the webs. The nets are hydrated to fix them into a single net unit and dried on a drying can until moisture is removed. The mesh is wrinkled by stretching the mesh during the weaving and drying process and subsequent relaxation after processing. A piece of layer is cut to about 10 inches by 10 inches in size and laid over the top of the other layers. The layers are sealed together using a pressure plate type heat seal device such as the Sentinel Model 808 heat sealer available from Sencorp (Hyannis, MA). The unsealed (unheated) bottom plate is shaped to include the composition and heat sealed using an untreated (heated) top plate that fits the bottom plate around the circular suture rim. Typical sealing conditions are to leave the machine at 300 ° C. for a residence time of about 3.5 seconds, supplying a pressure of about 30 psig, but may vary depending on the sealing device used. Keep the items in their packaging until they are cleaned and used.

Claims (12)

Disposable personal care articles suitable for cleansing and substantially dry, comprising: a) water insoluble substrate comprising: 1) a soft first layer exhibiting a Total Scratch Coverage Value of less than about 17%; And 2) a second layer for exfoliation placed adjacent to said first layer, wherein said second layer exhibits an overall scratch cover value of about 17% to about 70%; And b) a cleansing component in the vicinity of said first and second layers, comprising a foaming surfactant that is from about 10% to about 1000% by weight of the water-insoluble substrate. The article of claim 1, wherein said first and / or said second layer comprises fibers selected from the group consisting of natural fibers, synthetic fibers, and combinations thereof. The article of claim 1, wherein the first layer and / or the second layer comprise a material selected from the group consisting of nonwovens and wovens. 4. The article of claim 3, wherein the nonwoven is selected from batting, molded film, cellulosic nonwovens, and combinations thereof. The article of claim 1, wherein the cleansing component lies between the first layer and the second layer. The article of claim 1, wherein the first layer and the second layer are spot bonded to each other. The article of claim 1 for cleansing the skin and hair. A substantially dry disposable personal care article comprising: a) water insoluble substrate comprising: 1) a soft first layer exhibiting an average Profilometer Depth Value of less than about 8; And 2) a second layer for exfoliation adjacent to said first layer, said mean profilometer depth value of about 8 to about 80; And b) a cleansing component in the vicinity of said first and second layers, comprising a foaming surfactant that is from about 10% to about 1000% by weight of the water-insoluble substrate. Disposable personal care article suitable for conditioning and substantially dry, comprising: a) water insoluble substrate comprising: 1) a soft first layer exhibiting a total scratch cover value of less than about 17%; And 2) a peeling second layer exhibiting a total scratch cover value of about 17% to about 70%; And b) a therapeutically potent component in the vicinity of the water-insoluble substrate, comprising a therapeutic agonist that is from about 10% to about 1000% by weight of the water-insoluble substrate. A substantially dry disposable personal care article, comprising: a) water insoluble substrate comprising: 1) a soft first layer exhibiting an average profilometer depth value of less than about 8; And 2) a second layer for exfoliation adjacent to said first layer, said mean profilometer depth value of about 8 to about 80; And b) a therapeutically potent component in the vicinity of the water-insoluble substrate, comprising a therapeutic agonist that is from about 10% to about 1000% by weight of the water-insoluble substrate. A personal care kit comprising an article according to claim 1 and an additional article comprising a substrate and a therapeutically effective ingredient. The article of claim 1, further comprising an aesthetic component selected from the group consisting of calcium silicate microspheres, mica, and mixtures thereof.