KR100438001B1 - A composition of soap with containing zinc pyrithione - Google Patents

Abstract

The present invention relates to a soap composition containing zinc pyrithione, which is prepared by including 1 to 4 parts by weight of zinc pyrithione with respect to 100 parts by weight of the base, and has an excellent prevention and effect against dandruff and seborrheic dermatitis. It is convenient and economical to use as it is prepared in the form of soap by increasing the usability and physical properties of the soap composition by containing an antioxidant, a light shielding agent, and a cleaning agent.

Description

A composition of soap with containing zinc pyrithione}

The present invention relates to a soap composition containing zinc pyrithione, and more particularly, to a soap composition containing 1 to 4 parts by weight of zinc pyrithione with respect to 100 parts by weight of the base.

Since ancient times, humans have been pursuing cleanliness and beauty, and accordingly, the field of soap-based cleaner has developed.

A brief review of soap history shows that the Old Testament used lye for washing, and a type of clay called rotting urine (bleached clay) was used as a cleaner in the Roman days. The earliest writings of soap appear in the first book of the first century by scholar Prinius, The Museum, which states that soap was invented by the Gaul and made from resin and ash. Marseille, which prospered greatly as a place of origin after the 9th century, introduced the soap manufacturing technology around the 12th century and dominated the soap industry in Europe with good quality, leaving the name Marseille soap later. The 18th-century soap-making technology did not make any progress, but the practical foundations of soap production today were established by the invention of sodium carbonate from salts by levula in 1790 and the chemical composition of fats and oils by Scheubeng in 1811. It became. As oils and fats were gradually diversified, various oils and fats such as olive oil, palm oil and tallow were used. In the 90s, the recovery of glycerol became common. In the twentieth century, the industrialization of fat-and-oil hardening and the mechanization of each manufacturing process have been progressed, and the automation technology has been established. Today's soap manufacturing is developing into a highly rationalized industry.

Soap is a broad term that refers to metal salts of saturated and unsaturated higher fatty acids, resins, and naphthenic acids, and narrower means alkali metal salts mainly used for washing. In terms of soap, sodium salt (sodium stearate) of high fatty acid (CH ₃ (CH ₂ ) ₁₆ COOH) refers to sen soap, potassium salt (potassium stearate) refers to sweet soap, and ammonium salt (ammonium stearate) refers to liquid soap. Other metal salts are called metal soaps.

The molecules of the soap are hydrophobic moieties consisting of long chains of hydrocarbons (CH ₃ (CH ₂ ) ₁₆ COO ⁻ ) and hydrophilic moieties where the carboxyl groups (COO ⁻ ) are combined with alkali metals (Na ⁺ , Ca ²⁺ , NH ^4+, etc.). consist of. Soap is an anion (OH ^-) in the water and the cations (H ⁺⁾ is digested with the surface tension of water, lower the surface tension and foaming power, has an emulsion capacity, the available capacity powerful cleaning action.

Soap is usually produced through a saponification reaction, and the raw material is mainly Uji, palm oil palm oil, rice bran oil, palm kernel oil is used, and soybean oil, cottonseed oil, castor oil, peanut oil, fish oil and the like.

After mixing an appropriate amount of fats and oils and heat-melting at 60-70 degreeC, a sodium saponification reaction is performed by adding 80-90 degreeC sodium hydroxide. After removing the by-product soap, unreacted sodium hydroxide, glycerin layer, etc. from the soap in the upper layer and the submerged soap in the lower layer, the concentrated glycine and sodium hydroxide in the soap are usually added two to three times. Gets a soap layer. The soap layer thus obtained is dried to prepare a soap having a moisture content of about 13%, and then, an antioxidant, a complementary agent, a coloring agent, and the like are added to the soap thus prepared to form a molded product.

Soap prepared by the above method is somewhat effective in removing the dirt and waste of the skin, but sebum that maintains the homeostasis of the skin by excessive cleaning action is removed more than necessary to damage the skin, causing inflammation of the skin There was no satisfactory effect on pathogenic bacteria.

In order to make up for the shortcomings, methods have been proposed to improve the antimicrobial and skin protection effects by adding various nutrients or by adding various plant extracts. Soap is not developed much.

On the other hand, due to the pollution of the air and water resources due to industrial development, the skin of the human body is out of balance and the troubles of the skin due to stress are intensifying. The same is true for scalp and hair, which are part of the skin, and as the natural balance is inconsistent, more people complain of itching, dandruff, or rough hair.

Dandruff refers to a scalp state in which scalp is increased more than usual as dead skin cells formed by active metabolism of the scalp are formed in the form of keratin, which is formed by the secretion of the scalp sebaceous glands and dried. Covers all skin abnormalities. Dandruff gradually progresses to seborrheic dermatitis of the scalp accompanied by itching and inflammation, such as psoriasis or seborrheic dermatitis and ringworm (timeacapitis).

The root cause of dandruff is not yet well understood, but internal factors include endocrine hormone imbalance, nutritional metabolism, stress, and neurological factors such as stress and excessive growth of scalp cells. It is caused by Atterned Basal Metabalism, and it is caused by the complex effect of various factors such as inflammation due to growth and activity of scalp microorganisms and air pollution. Known. Among the various factors mentioned above, the growth and activity of the microorganism called Pityrosporum ovalae , which is present in the scalp, has been recognized for a long time as a major factor to exacerbate dandruff and itching. Is accepted

Therefore, in order to treat and prevent dandruff and itching, anti-dandruff substances containing ingredients that can effectively inhibit the proliferation and activity of the microbial phytirosporum obale, the main cause of dandruff, and normalize abnormal metabolic activity of the scalp cells, are used. It is desirable to.

Substances reported to have anti-dandruff include quaternary ammonium salts, antiallergic, allantoin, menthol, thymol, eucalyptol, sodium salicylate, and methyl salicylate. ), PVP-Indine Complex, Captan, Phenolic and Sodium Phenolate, SeS ₂ , SeS, CdS, Sulfur, Resorcinol, Hexachlophen, Biphen Hydrochloride, Tar (coal tar, phenol sodium), Climbazzole, Takanal, Corticosteroid, and Ketoconazole. .

Most of the anti-dandruff material is characterized by a strong bactericidal power, but the anti-dandruff property is very excellent, but it is difficult to use more than a certain amount because of side effects or toxicity.

Among the antidandruff substances, zinc pyrithione represented by the following Chemical Formula 1 is well known as an antidandruff substance in the art because of its strong bactericidal power and less side effects or toxicity.

In Chemical Formula 1, zinc (Zn) has two valence bonds with a sulfur (S) atom and two coordinating bonds with an oxygen (O) atom and has two extra coordination bonds. Zinc pyrithione (ZNP) is a white solid particle with a very high specific gravity of 1.782 at 25 ° C., and has a neutral pH of 7.3 in a 5% aqueous solution. In particular, it has a very low solubility in which only 15 ppm is dissolved in an aqueous solution at 25 ° C.

Zinc pyrithione is an antidandruff substance that can be applied as a bar, cream, lotion, shampoo, etc. to apply to dandruff scalp. However, when used in products such as creams, lotions and shampoos in emulsion form, it is difficult to stably and uniformly disperse the dispersion due to the low solubility of zinc pyrithione, and to the bottom of the container over time due to the high specific gravity. Problems such as precipitation form occur.

In order to solve the above problems, the inventors of the present invention can achieve a uniform and stable dispersion state in which bar bar solid zinc pyrithione is not dispersed in an aqueous solution. In view of the advantages, the main ingredient is a base of zinc pyrithione containing a soap composition to produce an anti-dandruff effect by confirming that it can be useful as a preventive light treatment of dandruff and seborrheic dermatitis and completed the present invention It was.

An object of the present invention to provide a soap composition containing zinc pyrithione.

In order to achieve the above object, the present invention provides a soap composition for dandruff treatment containing 1 to 4 parts by weight of zinc pyrithione based on 100 parts by weight of the base.

Hereinafter, the present invention will be described in detail.

The zinc composition for treating dandruff containing zinc pyrithione of the present invention contains a base and zinc pyrithione, and further includes a moisturizing agent, an antioxidant, a light shielding agent, a cleaning agent, and purified water.

The base is a fat or oil which is a raw material of soap, and contains a hydrophobic hydrocarbon portion and a hydrophilic carboxyl group that is soluble in water. In general, oils and fats are weak alkali salts of higher fatty acids, which are acid alkali neutralization reactions of higher fatty acids having 8 to 20 carbon atoms derived from animal and vegetable fats and oils such as tallow, lard, fish oil, palm oil, palm oil and palm kernel oil, and sodium, potassium and triethanolamine. The mixture of the obtained weak alkali salt is used. Soaps vary in properties depending on the fatty acids they contain. Saturated fatty acid soaps with less than 12 carbons are very hard and have good solubility stability. If above, the solubility decreases, but the washing power and the bubble power become strong. Since the base of the soap actually used is not a fatty acid of one element, but a mixture of several fatty acids, the soap is mixed according to the purpose and manufactured in consideration of firmness, solubility, foaming power, washing power, salting power, and preservation.

In addition, the content affects the manufacturing process and the physical properties of the final soap produced. If used excessively, the fragility of the soap is sticky and sticky in the association stage, which makes it difficult to extrude and mold and increase the defective rate.The pH of the manufactured soap shows weak alkalinity, which causes skin trouble when continuously used by people with sensitive skin. This tends to occur and is not preferable. On the other hand, when used in a small amount, the solidification time of the soap after the mold is prolonged, the hardness of the produced soap is lowered, and the lack of foaming power brings inconvenience to use.

Zinc pyrithione, an effective ingredient for removing dandruff, is represented by the following Chemical Formula 1.

Formula 1

Zinc pyrithione acts on the dandruff scalp and has an excellent antibacterial activity against Pyrosporum Ovale, a homozygote that is highly proliferating among scalp microorganisms and affects dandruff deterioration. It has the effect of inhibiting hyperliferation (mitosis, parakeratolysis) (cytpstatic effect, antihyperproliferation). Zinc pyrithione is well known in the art for being very effective in preventing and treating dandruff.

In the present invention, the zinc pyrithione is contained in an amount of 1 to 4 parts by weight based on 100 parts by weight of the base. As the content of zinc pyrithione increases, the dandruff removal effect of the prepared soap composition increases, but when used in excess, it becomes economically undesirable. According to the embodiment of the present invention, the zinc composition containing zinc pyrithione was found to effectively inhibit the growth of phytirosporum obale, a microorganism causing dandruff, and exhibited excellent sterilizing power. As a result, it can be seen that the dandruff removal effect is very excellent and the dandruff reduction rate is significantly higher than the composition containing no zinc pyrithione.

The zinc pyrithione-containing soap composition of the present invention further includes a moisturizing agent, an antioxidant, a light shielding agent, a cleaning agent and purified water.

Moisturizers are intended to maintain moisture and supply various nutrients to the skin and hair after use, and moisturizers that can be used in this field are commonly available. Preferred are glycerin, propylene glycol (PG), butylene glycol (BG), hexylene glycol (HG), urea, dexantenol, isopentyldiol and blood One or a mixture of two or more selected from pyrrolidone carboxylic acid and salts thereof (sodium) are used. In the present invention, the moisturizer is contained in an amount of 1 to 2 parts by weight based on 100 parts by weight of the base.

Antioxidants can further increase the antidandruff properties of soap compositions by inhibiting the oxidation of zinc pyrithione. As antioxidants, tocopherol acetate, butylated hydroxy anisole (BHA), ascorbyl palmitate, and etidronic acid are used, and preferably tocopherol acetate is used. In the present invention, the content of antioxidant is contained in 1 to 2 parts by weight based on 100 parts by weight of the base.

The light-shielding agent decolorizes and prevents the color change of the soap itself and maintains the color of the soap. Titanium oxide, dipropylene glycol salicylate, and methyl salicylate are used as the light shielding agent, and titanium oxide is preferably used. In the present invention, the light shielding agent is contained in an amount of 0.05 to 0.2 parts by weight based on 100 parts by weight of the base.

Detergents impart a detergency and foaming power of the soap to improve the feel of the soap and serve to condition hair. As a detergent, cocamidopropyl betaine containing an alkyl group of C ₈ to C ₂₂ which is an amphoteric surfactant, coco-betaine, alkyl betaine, cocamide DEA, and coca Choose from amide MEA, glyceryl cocoate, more preferably cocamipropylbetaine. In the present invention, the content of the detergent is contained in 4 to 8 parts by weight based on 100 parts by weight of the base. At this time, when used in a smaller amount than the above range, the cleaning effect and foaming power is lowered, and when used in excess, the cleaning effect and foaming power is excellent, but the hardness of the prepared soap is lowered, which is not preferable.

Purified water is used to dissolve the solid component in the additive and is added 2 to 4 times by weight ratio of the solid component.

In addition, additives such as preservatives, pH adjusters, flavorings, dyes, etc. may be further added to the zinc pyrithione-containing soap composition by those skilled in the art.

In addition, the soap composition containing the base and zinc pyrithione of the present invention can be produced by a conventional soap production method. Base and zinc pyrithione and other additives are added to the coalescing machine, fed together, and then extruded and molded to prepare a soap composition containing zinc pyrithione.

In the associating step, the additive additionally added to the zinc composition containing zinc pyrithione is divided into a liquid component and a solid component, respectively, and then mixed, and then each liquid and solid component is mixed in one mixer and finally in the coalescer. Is injected into.

A method for preparing a soap composition containing additives will be described for each step.

First, the components are mixed in different mixers and finally in the coalescer (step 1).

Base and zinc pyrithione as main components are mixed at room temperature for 10 to 30 minutes in an associative group. A liquid mixture except for purified water is added to the liquid mixer and mixed for 5 to 10 minutes to prepare a liquid mixture. The solid component is added to the solid mixer in purified water and mixed for 3 to 10 minutes to prepare a solid mixed solution. At this time, add 2/3 of the corresponding amount of purified water, add the solid component, and then add the remaining purified water 1/3 and mix so that the solid component is completely dissolved. The completely dissolved solid component mixture is poured into the liquid mixer containing the liquid mixture and mixed for 5 to 10 minutes. The mixed liquid uniformly mixed in the liquid mixer is injected into an associated machine in which the main components are mixed and stirred for 10 to 20 minutes to prepare a uniform soap composition. In this case, the liquid mixer and the solid mixer used in the manufacture of soap may be a SUS tank, a colloid mill, or the like.

Next, the soap composition mixed in step 1 is extruded in an extruder (step 2).

Next, the present invention is completed by forming a soap by molding the soap extruded in step 2 into a desired shape (step 3).

Thereafter, the soap typed in step 3 is packaged and shipped as a product.

As described above, by using the soap composition containing the base and zinc pyrithione according to the present invention, a soap containing zinc pyrithione was prepared through the steps of association, extrusion and molding, and further moisturizing agent, antioxidant By containing a light-shielding agent, a detergent, and purified water, a soap having improved physical properties such as moisture retention and foaming power can be prepared.

The zinc pyrithione-containing soap of the present invention has the effect of preventing and treating dandruff and seborrheic dermatitis, and is manufactured in the form of a bar, which is simple and economical to use.

Hereinafter, the present invention will be described in detail by way of examples.

However, the following examples are merely to illustrate the invention, but the content of the present invention is not limited to the following examples.

<Examples 1-2, Comparative Examples 1-3> Preparation of soap composition for dandruff treatment

To prepare a soap composition containing the composition of Table 1.

Base and zinc pyrithione were added to the coalescer and combined at room temperature for 20 minutes. Glycerin, tocopherol acetate and cocamidopropyl betaine were added to the SUS tank and mixed for 5 to 10 minutes to prepare a liquid mixture. 2/3 of purified water was added to a colloid mill, polyethylene glycol 20,000 and titanium oxide were added, and then 1/3 of purified water was added thereto, mixed for 5 minutes, and completely dissolved to prepare a solid mixed solution. Subsequently, the valve of the colloid mill was opened, the solid mixture was poured into the SUS tank containing the liquid mixture, mixed, and the mixture was added to the coalescer and finally federated for 15 minutes. Thereafter, the soap composition was prepared by extrusion and mold molding according to a conventional soap manufacturing process.

Composition (part by weight) Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Base ¹⁾ 100 100 100 100 100 Zinc pyrithione ²⁾ 3 3 6 6 - Moisturizer Glycerin ³⁾ - One - 2 One Polyethylene glycol ⁴⁾ - One - 2 One Antioxidant Tocopherol acetate ⁵⁾ - 1.5 - 1.5 1.5 Shading Titanium oxide ⁶⁾ - 0.1 - 0.1 0.1 detergent Cocamidopropylbetaine ⁷⁾ - 6 - 6 6 Purified water - 4 - 6 4 Note) 1) Soap Pellets, Where to buy: Hwadong Chemical 2) Where to buy: Samo Pharmachem 3) Where to buy: Wonpoong 4) Molecular weight 20,000, Where to buy: Kangsan 5) Where to buy: Kangsan 6) Where to buy: Wonpok 7) Where to buy: Miwon superior

Experimental Example 1 Inhibitory Effect of Microbial Growth

Growth inhibition and bactericidal rate of Pyrosporum ovalae of zinc pyrithione, a microorganism causing dandruff, was measured.

Slow growth

The aqueous solution of soap containing zinc pyrithione is expressed by the growth inhibition (%) indicating the degree of inhibiting the growth of microorganisms, compared to the aqueous solution of soap containing no zinc pyridion. It measured by the method. 0.5 ml of the stock solution containing about 1000 cuf / ml of phytirosporum obale was mixed with 0.5 ml of 2% soap solution (2 g of soap suspended in 100 ml of sterile distilled water), and then poured into a plate medium and poured at 30 ° C. Incubated for 48 hours at. Microorganisms that do not grow on plate media when the number of microorganisms on each plate medium is counted and treated with soap solution containing zinc pyrithione as compared to the case where soap solution does not contain zinc pyrithione The number of colonies is shown in Table 2 below, expressed as a growth inhibition (%).

Sterilization rate

The aqueous solution of soap containing zinc pyrithione was expressed as a sterilization rate (%) indicating the degree of sterilization of pytirosporum obale compared to the aqueous solution of soap containing no zinc pyrithione and measured as follows. . 0.5 ml of stock solution containing about 1000 cfu / ml of Pytirosporum obale was mixed with 0.5 ml of 2% soap solution (solution of 2 g of soap suspended in 100 ml of sterile distilled water) in a centrifuge tube, and then 30 It was allowed to stand at 10 ° C. for 10 minutes to allow the soap solution to contact Pytirosporum Ovalle. The supernatant was carefully removed by centrifugation (8000 rpm, 5 minutes), and then 1 ml of physiological saline was poured into the precipitated pytyrosporum obale to wash the soap solution. After repeating this process 2 to 3 times, the precipitated phytirosporum obale was poured with 1 ml of physiological saline solution and poured into a plate medium and incubated at 30 ° C. for 48 hours. The bactericidal effect was decreased when the number of colonies of pytirosporum obale on each plate medium was counted and treated with soap solution containing zinc pyrithione as compared to the case with soap solution containing zinc pyrithione. The number of phytirosporum obale was expressed as a relative percent of sterilization, which is shown in Table 2 below.

Experimental Example 2 Dandruff Reduction Effect and Feeling Test

In order to determine the dandruff reduction effect and usability, the following test was performed.

Test group dandruff is severe or has dandruff, seborrheic dandruff on the scalp or psoriatic cases by severe itching selected men and women aged 20-50 in 50 people one by one to five groups 10 months to test the results table 2 is shown.

Before the start of the test, trituration with a normal shampoo is carried out, and after collecting the dandruff accumulated for 3 days, the weight of the collected dandruff and the composition of Examples 1 to 2 and Comparative Examples 1 to 4 are carried out once every 2 days. The weight of the dandruff accumulated for 3 days after the end of the test was evaluated. The accumulated dandruff was collected directly from the scalp using a vacuum suction device, and the rate of dandruff reduction was calculated based on Equation 1 below. At this time, the anti-dandruff effect was determined to be effective only when the dandruff reduction rate is 25% or more.

The usability was dependent on the feeling (sensation) of the test group and the results were obtained for the degree of relieving itching and the quality of bubbles.

Experimental Example 3 Workability

When soap was manufactured by the manufacturing process of general fatty acid soap, it was evaluated that the soap sticked to the machine and the sticky mold release state in the molding, extrusion and mold state.

Experimental Example 4

The soap composition was stored in a constant temperature and humidity chamber at room temperature and 40 ° C. for 3 months, and the change in the appearance of the sample was determined visually compared to the room temperature storage sample at weekly intervals.

division Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Antidandruff effect Inferior Growth (%) 0 0 0 0 1020 Sterilization Rate (%) 100 100 100 100 0 Average Dandruff Reduction Rate (%) 50.5 55.0 56.0 57.5 5 Anti-dandruff effect (persons) have 46 49 45 46 3 none 0 0 0 0 40 I do not know 4 One 5 4 7 Feeling Relieves itching ++ ++ ++ ++ - Air quality + ++ - + ++ Workability Good Good Good Bad Good Jingxian stability stability Bad stability stability * ++: Very good +: Excellent ±: Normal-: Somewhat inferior-: Inferior

As described in detail above, according to the present invention, a soap composition was prepared by further adding a moisturizing agent, an antioxidant, a light shielding agent, a cleaning agent, and purified water to a composition containing a base and zinc pyrithione. Soap composition for the treatment of dandruff of the present invention inhibits the growth of phytirosporum obale microorganism that causes dandruff and shows excellent bactericidal power, the degree of itching is resolved somewhat after a month of use, and foaming power when used It was found to be excellent. Therefore, the soap composition for treating dandruff of the present invention has an excellent anti-dandruff effect, and thus can be effectively applied to the prevention and treatment of dandruff and seborrheic dermatitis. .

Claims (6)

delete 1 to 4 parts by weight of zinc pyrithione, 1 to 2 parts by weight of moisturizer, 1 to 2 parts by weight of antioxidant, 0.05 to 0.2 parts by weight of light shielding agent and 4 to 8 parts by weight of cleaning agent are included. Soap composition for dandruff treatment. The moisturizing agent of claim 2, wherein the moisturizing agent is glycerin, propylene glycol (PG), butylene glycol (BG), hexylene glycol (HG), urea, dexpanthenol, isopentyldiol (Isopentyldiol) and pyrrolidone carboxylic acid (pyrrolidone carboxylic acid) and salts thereof (sodium) selected from one or a mixture of two or more selected from the soap composition for treating dandruff. The soap composition of claim 2, wherein the antioxidant is selected from tocopherol acetate, butylated hydroxyanisole (BHA), ascorbyl palmitate or etidronic acid. The soap composition of claim 2, wherein the light shielding agent is selected from titanium oxide, disalicylic acid dipropylene glycol salicylate, or methyl salicylate. The cleaning agent according to claim 2, wherein the cleaning agent is a cocamidopropyl betaine containing a C ₈ to C ₂₂ alkyl group, a coco-betaine, an alkyl betaine, a cocamide DEA, a coca Soap composition for the treatment of dandruff, characterized in that selected from amide MEA (cocamide MEA) or glyceryl cocoate (glyceryl cocoate).