KR100316894B1 - extruding machine for producing chewable pill - Google Patents

Abstract

According to the present invention, a base 9, which forms a base, a chewable base 5 formed above the base die 3, and a core 7 containing a drug, respectively, are formed to receive a housing 9, 11), hydraulic cylinders 17 and 19 installed in parallel with the respective discharge holes 13 and 15 opposite sides of the enclosures 9 and 11, and discharge holes 13 opened in one side of the enclosure 9; The discharge pipe 21 extending from the outer shell discharge pipe 21, the discharge hole 15 is opened in one side of the housing 11, the discharge hole (15) opposite side end of the discharge pipe 21 inside the discharge pipe 21 Chew, characterized in that the core discharge pipe 23 is bent at a right angle so as to be in the same line as the center line of the) and the shaft nozzle 25 is detachably coupled to the discharge end of the shell discharge pipe (21) A tablet manufacturing extrusion device, comprising a core containing a drug and surrounding the core Is intended to prepare a drug in an easy-to-take tablet form by simultaneously extruding a chewable base as an outer sheath.

Description

Extruding machine for producing chewable tablets {extruding machine for producing chewable pill}

The present invention relates to an extruder for producing chewable tablets, and more particularly to a core consisting of a drug-containing jelly or similar composition and a chewable base surrounding the core, for example in the form of gum, candy or caramel. The present invention relates to an apparatus used to produce chewable tablets which are easily extruded and manufactured in the form of a coaxial rope and then cut into tablets to make tablets easy to take.

In general, tablets are prepared by adding an excipient to the containing drug and tableting, so it is inconvenient to swallow or chew.

Chewable tablet which gives elasticity or chewability to make chewable to solve such discomfort or adds sweetness to improve taste, and melts or chews in mouth and enters gastrointestinal tract from oral cavity in solution or granule state. ) Has been developed.

Such soft tablets are subjected to the following process to mix the main drug and excipient components together, melt them at a high temperature to prepare the whole in a soft candy or jelly state.

As shown schematically in FIG. 1, conventional chewable tablets are prepared in a state of jelly having a liquid property of a chewable base such as gum, soft candy, or caramel, which is easy to take by improving texture and aesthetics in the first oral cavity. The preparation step is performed (S1).

In order to impart a certain level of strength to the chewable base manufactured through the preparation step, the high-temperature chewable base mass having a certain degree of fluidity is first cooled (S2).

When the primary cooling is completed, the main ingredient drugs having various pharmaceutical ingredients, such as vitamins, herbal medicines, aspirin, gastrointestinal diseases treatment agents, etc., are injected into the chewable base mass at high temperature and mixed (S3).

Then, the apparatus such as a batch roller (batch roller) is extruded to a relatively large diameter of the chur shape base having a somewhat soft to a rope size of a relatively large diameter while at the same time cooling to some extent to have some rigidity (S4).

The extruded rope-size chewable base is compressed into a suitable size and shape convenient for taking by a stamping device, for example, to make a tablet in the form of a cuboid (S5).

The tableted tablet is subjected to secondary cooling which is cooled to room temperature while passing through a cooling conveyor to facilitate the carrying or packaging of the consumer (S6), and then packaged by a packing machine (S7) to produce a single tablet medicine.

However, the tablets thus prepared are first mixed with the main drug and the excipient component made from the chewable base in a molten state at a high temperature, so that the physicochemical properties of the drug which is unstable to heat are changed or the drug component itself is volatilized to lower the drug efficacy. There was a problem that could be.

In addition, these tablets have a problem in that it is inconvenient to take the chewable base of the grainy texture as if chewing sand or dry feeling like chewing chalk.

In addition, although the drug itself is packaged, there is a problem that the drug present on the surface of the chewable base causes a component change due to contact with air.

Therefore, the present invention has been devised to solve the above problems, and can be used in any place without water, and improve the texture and taste felt in the oral cavity when the consumer eats by dissolving or chewing with excellent taste and aroma when taking Separately from the chewable base, which is the outer shell, the main ingredient is simultaneously contained in the inner core of the tablet in the state of jelly or chewable base at room temperature so that the physicochemical properties of the main ingredient of the drug do not change, so the main ingredient can be maintained as it is. An object of the present invention is to provide a chewable tablet manufacturing apparatus having an extrusion device for simultaneously extruding the core and the shell of the excipient.

1 is a block diagram illustrating a conventional chewable tablet manufacturing method.

Figure 2 is a partially cutaway perspective view of the tablet produced by the extrusion apparatus of the present invention.

Figure 3 is a partially cutaway perspective view showing a rope-like shell and core extruded by the extrusion device of the present invention.

Figure 4 is a cross-sectional view of the extrusion device for producing chewable tablets according to the present invention.

5 is a front cross-sectional view of FIG. 4.

6 is a side view of FIG. 4.

FIG. 7 is a perspective view illustrating the shaft nozzle, the aperture control port, and the discharge nozzle shown in FIG. 4; FIG.

8 is a block diagram illustrating a tablet manufacturing process by the extrusion apparatus of the present invention.

* Description of the symbols for the main parts of the drawings *

1 Extruder 2 Tablet

3: base die 4: rope

5: jacket 7: core

9,11: enclosure 13,15: shell and core discharge hole

17,19: hydraulic cylinder 21,23: shell and core discharge pipe

25: shaft diameter nozzle 26,27,29: hot water jacket

31: pressure-resistant wall 33: shaft diameter nozzle discharge hole

37: discharge nozzle

The present invention thus provides an opening in one side of a base die forming a base, a housing provided above the base die, each of which contains a chewable base and a core containing a drug, and one side of the enclosure. Discharged by connecting the discharge hole, the hydraulic cylinder installed in parallel with each discharge hole opposite side of the housing, the shell discharge pipe extending from the discharge hole opened on one side of the shell housing, and the discharge hole opened on one side of the core housing. Provides an extrusion device for producing chewable tablets, which consists of a core discharge pipe bent at right angles so that the opposite end of the ball is flush with the center line of the discharge pipe, and a shaft nozzle detachably coupled to the discharge end of the discharge pipe. do.

Hereinafter, an embodiment of the present invention will be described in detail with reference to the accompanying drawings.

Extruder 1 for producing a chewable tablet according to an embodiment of the present invention is a device for manufacturing a tablet (2) shown in Figure 2, as shown in Figure 3 the shell 5 and the core (7) The tablet 2 is produced by simultaneously extruding and cutting in the form of a rope 4.

Extrusion apparatus 1 of the present invention has a configuration as shown in Figures 4 to 6 for extruding the shell 5 and the core 7 in the form of a coaxial rope 4 as shown in Figure 3 have. That is, the base die 3 forming the base, the housings 9 and 11 for accommodating the outer shell and the core, the pair of hydraulic cylinders 17 and 19 extruding the outer shell and the core accommodated in the housings 9 and 11, extruded It consists of a core and the outer shell discharge pipe (21, 23) and the shaft diameter nozzle (25) mounted at the end of the discharge pipe (21, 23) to discharge the shell and the core, respectively.

Here, the base die 3 is composed of a frame in the form of a enclosure as shown in Figure 5, the hydraulic cylinder (17, 19) drive motor 39, a hot water pump and a hot water pump drive motor is installed therein It is. In addition, a plurality of casters 41 are mounted on the lower surface and can be moved to a desired position, and after moving to a predetermined position, a fastening rod for screwing up and down on one side of the lower surface to fix the device 1 to the ground 43 is provided.

Enclosures 9 and 11 installed on the base die 3 have a core 9 containing the encapsulation 9 and the weak component for accommodating the chewable base 5 used as the outer shell as shown in FIG. 4. The housing 11 for accommodating is arranged in parallel from side to side. Each of the enclosures 9 and 11 is preferably formed in a cylindrical shape to facilitate the extrusion of the shell and the core, and can be freely set in diameter and shaft diameter, but have the same shaft diameter for ease of assembly. The diameter can be set variably according to the mixing ratio of the outer shell and the core according to the use or type. And the upper surface of each enclosure (9, 11) is provided with a hopper 45 for the sheath or core input as shown in Figure 5 and 6, the outer shell (5) and the core (7) on one side Hydraulic cylinders 17 and 19 for compression are provided in parallel, and the outer shell and core discharge pipes 21 and 23 are connected to the opposite sides of the hydraulic cylinders 17 and 19, respectively.

In addition, on both sides of the enclosure (9, 11), the outer shell (5) and the core (7) is compressed by the hydraulic cylinders (17, 19) to support the high pressure generated in each of the enclosure (9, 11) Of the pressure-resistant walls 31, and these pressure-resistant walls 31 are fixed to the left and right sides of the enclosures 9 and 11 by the nut 49 by six support rods 3 each up and down as shown in FIG. It is.

The pair of hydraulic cylinders 17, 19 adapted to pressurize and compress the shell 5 and the core 7 inside the enclosures 9, 11 are shown in FIGS. 4 and 5. It extends laterally in parallel on one side, the pressure piston (51, 53) for compressing the outer shell (5) or the core (7) is provided so as to be movable left and right, respectively. The pressurizing pistons 51 and 53 have the same outer diameter as the inner diameters of the respective enclosures 9 and 11 and slide along the inner wall surfaces of the enclosures 9 and 11.

The outer shell discharge pipe 21, which is connected to the outer shell 9 through the outer shell discharge hole 13 penetrating the center of the wall surface opposite the hydraulic cylinder 17 of the shell body 9, is shown in FIGS. 4 and 5. Protruding laterally from the side of (9), the shaft diameter nozzle 25 for squeezing the outer shell 5 compressed by the pressure piston 51 is detachably attached.

Therefore, as shown in FIG. 7, the shaft diameter nozzle 25 is tapered in a state in which the inner surface 55 is curved inclined. In addition, the inside of the discharge hole 33 of the shaft nozzle 25 is fitted with a leaflet-shaped aperture control 57, the aperture control 57 is removable and has a discharge hole 59 of various diameters According to the selection of the purification rope 4 having various apertures can be produced.

As shown in FIGS. 4 and 6, the core discharge pipe 23 connected to the enclosure 11 through the core discharge hole 15 through-opened in the center of the wall surface of the enclosure 11 opposite the hydraulic cylinder 17 is as shown in FIGS. 4 and 6. It protrudes from the side wall of the enclosure 11 and is bent 90 ° forward to be inserted and mounted on the same axis into the shell discharge pipe 21, and the insertion portion of the discharge pipe 21 is bent 90 ° laterally to form a roughly shaped shape. It is supposed to be worn.

In addition, as shown in more detail in FIG. 7, a discharge nozzle 37 mounted adjacent to the same diameter axis as the shaft nozzle 21 is detachably screwed to the discharge side end of the core discharge pipe 23. have. Therefore, the operator can selectively use the discharge nozzle 37 according to the discharge diameter of the desired core 7, wherein the nozzle 37 is tapered so that the diameter becomes smaller while going to the discharge side like the normal nozzle.

And as can be seen in Figure 4, around the outer shell and core housing (9, 11) and the outer shell and core discharge pipe (21, 23) to maintain the temperature inside the appropriate level, respectively, to prevent the shell or core from hardening The jackets 26, 27, and 29 are provided, and the hot water jacket 26 can achieve a predetermined heat dissipation or heating effect even when only the left and right sides of the circumferential surfaces of the enclosures 9 and 11 are enclosed. In addition, the outer shell and core discharge pipes (21, 23) having a relatively small internal volume is a pipe-type hot water jacket (27) so as to surround all the external exposed portion of the discharge pipe (21, 23) in order to maintain an appropriate level of heat dissipation or heating effect (29) is preferable.

According to the extrusion apparatus 1 of this invention comprised in this way, manufacture of a tablet can be performed through the process shown in FIG.

First, by using a separate device to manufacture a chewable base of the outer shell (5) and the jelly-like solid solution of the core 7 respectively, the outer shell (5) is transferred to the extrusion device (1) of the present invention, the solid solution is Transfer to main raw material mixing device (P1).

The solid solution of the core 7 transferred to the main raw material mixing device is mixed with the drug substance material at room temperature and then transferred to the extrusion device 1 (P2).

The shell 5 and the core 7 respectively transferred to the extruder 1 are charged into the enclosures 9 and 11 via the hopper 45 and then extruded simultaneously through the extruder 1 to the rope 4 It is transferred to the stamping device through the cooling conveyor in the form (P3).

The outer shell 5 and the core 7 in the form of a rope 4 transferred to the stamping device are cut into appropriate sizes and compressed into one tablet 2 (P4).

Tableting (2) is completed while packing the packaging process is produced as a finished product (P5).

Here, the extrusion step (P3) will be described in more detail as follows.

When the shell 5 and the core 7 are introduced into the enclosures 9 and 11 through the hopper 45 by manual or automated lines, the hydraulic cylinders 17 and 19 start to operate. Each pressurized piston 53 then moves to the left and gradually compresses the shell 5 and core 7 in the enclosure 9, 11.

Accordingly, the outer shell 5 pressurized toward the outlet 13 is pushed into the outer shell discharge pipe 13 and squeezed out through the shaft diameter nozzle 25, and at the same time, the core 7 in the enclosure 11 is also the core discharge pipe ( 15, it is squeezed out toward the shaft nozzle 25 through the discharge port 35 of the discharge nozzle 37. At this time, since the shaft nozzle 25 and the discharge hole 35 are adjacent to each other as shown in FIG. 4, the outer shell 5 and the core 7 are squeezed out to form the rope 4 in the form shown in FIG. 3. The shell 5 and the core 7 are heated or cooled by the hot water jackets 26, 27, and 29 to maintain the proper viscosity suitable for extrusion throughout the extrusion operation, and the extruded rope 4 In the next step (P4) it is cut to the finished tablet.

As described above, according to the extruder of the present invention, it is easy for children or the elderly to take tablets by enclosing the core of caramel or gum, which is easy to take, when the tablets are inconvenient to take. In addition, by increasing the chewing time in the oral cavity to facilitate the absorption of the drug component through the oral body.

In addition, by adding a drug component directly to the chewable base at a high temperature without mixing, it is possible to prepare a solid solution having a separate drug component and to extrude it simultaneously with the skin to prevent deformation of the drug component due to the high temperature treatment, and also in the storage step after manufacture. It is possible to prevent the weak component from deforming due to contact with air.

In addition, by simultaneously extruding the outer shell and the core portion by one extrusion apparatus, the tablet manufacturing process can also be significantly simplified.

While the invention has been shown and described with respect to particular embodiments, it will be apparent to those skilled in the art that various modifications and variations can be made without departing from the spirit and scope of the invention as set forth in the appended claims. Anyone can grow up easily.

Claims (4)

A base die (3) forming a base, a housing (9, 11) arranged above the base die (3) to receive a chewable base (5) and a core (7) containing a drug, respectively, Extends from the hydraulic cylinders 17 and 19 disposed in parallel with the respective discharge holes 13 and 15 of the enclosures 9 and 11 and the discharge holes 13 opened in one side of the enclosure 9; The outer shell discharge pipe 21, which is connected to the discharge hole 15 opened in one side of the enclosure 11, and the discharge hole 15 opposing side end is the center line of the discharge pipe 21 in the outer shell discharge pipe 21. Core discharge pipe 23 is bent and extended at a right angle so as to be in line with the axis, the shaft nozzle 25 is detachably coupled to the discharge end of the shell discharge pipe 21, and the circumference of the respective housing (9, 11) and Hot water jacket (26, 27, 29) is installed around the shell and core discharge pipe (21, 23), respectively Abrasion refined manufacture extrusion device. delete 2. The chewable device according to claim 1, wherein both sides of the enclosures 9 and 11 are equipped with pressure-resistant walls 31 for supporting the high pressure generated in the enclosure by the hydraulic cylinders 17 and 19. Extrusion apparatus for manufacturing tablets. The removable core discharge nozzle 37 of claim 1, wherein the discharge port 35 is disposed on the same plane as the discharge hole 33 of the shaft nozzle 21 at the discharge end of the core discharge pipe 23. Chewable tablet manufacturing extrusion device, characterized in that.