KR100313480B1 - Biomagnetic measuring device - Google Patents
Biomagnetic measuring device Download PDFInfo
- Publication number
- KR100313480B1 KR100313480B1 KR1019980047405A KR19980047405A KR100313480B1 KR 100313480 B1 KR100313480 B1 KR 100313480B1 KR 1019980047405 A KR1019980047405 A KR 1019980047405A KR 19980047405 A KR19980047405 A KR 19980047405A KR 100313480 B1 KR100313480 B1 KR 100313480B1
- Authority
- KR
- South Korea
- Prior art keywords
- measuring
- sensor
- biomagnetic
- channel
- signal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/242—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Physiology (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Signal Processing (AREA)
- Artificial Intelligence (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Measuring Magnetic Variables (AREA)
Abstract
본 발명은 생체자기 측정장치에 관한 것으로, 특히 이중 이완발진 스퀴드 방식의 집적화된 평면형 미분계를 사용하고, 기준 채널을 사용하여 신호대 잡음비를 높이고, 인체표면에 대해 접선방향의 자장성분을 측정하고, 센서가 모듈화되어 센서의 교체가 용이한 것이 특징으로 되어 있다.The present invention relates to a biomagnetic measuring apparatus, and in particular, using an integrated planar differential meter of the dual relaxation oscillation squid method, using a reference channel to increase the signal-to-noise ratio, measure the magnetic field component in the tangential direction to the human body surface, The sensor is modular, so it is easy to replace the sensor.
상기 본 발명으로서 뇌, 심장, 태아의 심장, 척수 위, 창자로부터 발생되는 자기장을 측정하는 장치로 활용된다.The present invention is utilized as a device for measuring the magnetic field generated from the brain, heart, heart of the fetus, spinal cord stomach, intestines.
Description
본 발명은 고감도 자장측정 센서인 스퀴드(SQUID : superconducting quantum interference device)를 이용한 생체자기 측정장치에 관한 것으로, 특히 이중이완 발진 스퀴드(double relaxation oscillation SQUID) 방식의 집적화된 평면형 미분계를 사용하고, 기준채널을 사용하여 신호대 잡음비를 높이고, 인체표면에 대해 접선방향의 자장성분을 측정하고, 센서를 모듈화하여 센서교체가 용이하게 한 것이다.The present invention relates to a biomagnetic measuring device using a superconducting quantum interference device (SQUID), which is a high-sensitivity magnetic field measurement sensor. In particular, an integrated planar differential meter using a double relaxation oscillation SQUID method is used. Using the channel to increase the signal-to-noise ratio, to measure the magnetic field component in the tangential direction to the human body surface, and to modularize the sensor to replace the sensor.
상기 본 발명으로서 뇌, 심장 태아의 심장, 척수, 위, 창자로부터 발생되는 자기장을 측정하는 장치로 활용된다.As the present invention, the brain, heart fetal heart, spinal cord, The stomach is used as a device to measure the magnetic field generated from the intestines.
종래에는 자장신호에 대한 스퀴드 출력전압 계수가 작은 직류 스퀴드를 채택하며 자속변조를 사용하고, 스퀴드와 실온의 전단증폭기 사이에 임피던스 매칭회로를 사용하며 위상민감 검출방법을 사용한다.Conventionally, a DC squid having a small squid output voltage coefficient for a magnetic field signal is adopted, magnetic flux modulation is used, an impedance matching circuit is used between the squid and the room temperature shear amplifier, and a phase sensitive detection method is used.
인체표면에 수직한 법선성분의 자장을 측정하고, 검출코일은 권선형 미분계를 사용하며, 서로 다른 채널의 검출코일이 하나의 코일 지지대에 고정되며 검출코일과 스퀴드가 별개의 몸체로 구성되며 스퀴드를 초전도 튜브로 차폐시킨다.The magnetic field of the normal component perpendicular to the human body surface is measured, the detection coil uses a winding differential meter, the detection coils of different channels are fixed to one coil support, and the detection coil and the squid are composed of separate bodies. Is shielded with a superconducting tube.
그러나 상기 종래 기술은 임피던스 매칭회로는 센서부의 부피를 증가시키고, 자속변조 및 위상민감 검출방법은 스퀴드 구동회로를 복합하게 한다.However, in the conventional art, the impedance matching circuit increases the volume of the sensor unit, and the magnetic flux modulation and phase sensitive detection method makes the squid driving circuit complex.
권선형 미분계는 균일한 자기잡음을 소거시키는 소거비가 부족하고 검출코일과 스퀴드 홀더가 차지하는 부피가 커서 동작을 위해 냉매가 많이 필요함.The winding differential system lacks an erasing ratio for eliminating uniform magnetic noise and requires a large amount of refrigerant for operation due to its large volume occupied by the detection coil and the squid holder.
또한 센서 교체시 스퀴드와 검출코일을 분리시킨 후 초전도결합을 해야하므로 센서 교체과정이 매우 복잡하고, 초전도차폐는 자기장의 공간적 분포를 불균일하게 하므로 미분계의 외부 잡음 소거비를 나쁘게 한다.In addition, the sensor replacement process is very complicated since the superconducting coupling must be performed after separating the squid and the detection coil, and the superconducting shield makes the spatial distribution of the magnetic field uneven, which makes the external noise cancellation ratio of the differential system worse.
법선 성분의 센서배열은 인체내의 활동전류가 만드는 자장을 측정하기 위해 많은 수의 센서를 넓은 부위에 배치시켜 측정해야 한다.The sensor array of the normal component should be measured by placing a large number of sensors in a wide area to measure the magnetic field generated by the active current in the human body.
본 발명은 스퀴드 구동회로를 획기적으로 간단히 하여 시스템의 신뢰성을 개선시키며 시스템의 가격을 내리고, 검출코일을 스퀴드와 같은 기판에 집적화시켜 센서의 신뢰성을 크게 높이고 센서를 모듈화하여 센서의 교체를 쉽게 하기 위한 것이다.The present invention dramatically improves the reliability of the system by dramatically simplifying the squid driving circuit, lowers the price of the system, integrates the detection coil onto a substrate such as squid, greatly improves the reliability of the sensor, and modularizes the sensor to easily replace the sensor. will be.
환경 자기잡음을 측정하기 위해 기준채널을 이용하여 신호대 잡음비를 개선시키고, 인체내의 정보를 얻는데 필요한 센서 커버면적을 줄이기 위한 것이다.In order to measure environmental magnetic noise, the reference channel is used to improve the signal-to-noise ratio and to reduce the sensor cover area required for obtaining information in the human body.
본 발명을 구성하는 제 1 발명으로서 뇌, 심장, 태아의 심장, 척수, 위, 창자로부터 발생되는 자장을 측정하는 장치를 구성하는데 있어서 이중이완발진 스퀴드를 채택하고, 자장 검출코일(1)이 스퀴드(2)와 동일 기판에 집적화된 평면형 미분계를 (3)를 사용하는 방법이고, 제 2 발명은 상기 제 1 발명에 있어서 인체표면에 수직한 방향을 z방향, 인체표면을 x와 y방향이라 할때 신호채널 (4)의 평면형 분계(3)를 dbx/dz와 dby/dz성분을 측정하도록 배치시키고, 환경자기잡음을 측정하기 위한 기준채널(5)로서 dBx/dz와 dBy/dz 성분을 측정하는 미분계 (6)와 x,y,z방향의 자장성분을 측정하는 자력계(7)을 채택하고 신호채널(4)과 기준채널(5)을 이용하여소프트웨어 미분계를 사용하는 방법이고, 제 3 발명은 생체자기 신호측정을 위한 신호채널(4)의 평면형 미분계(3) 및 에폭시블럭 (9)을 모듈화하여 센서의 교체 및 보수를 용이하게 하는 것이다.As a first invention constituting the present invention, in the configuration of a device for measuring a magnetic field generated from the brain, heart, fetal heart, spinal cord, stomach, and intestine, a dual-relaxed squid is adopted, and the magnetic field detection coil 1 is squid. The method of using (3) is a planar differential meter integrated on the same substrate as in (2). In the first aspect of the invention, the direction perpendicular to the human body surface is referred to as the z direction and the human body surface is referred to as the x and y directions. When the planar demarcation (3) of the signal channel (4) is arranged to measure the db x / dz and db y / dz components, dB x / dz and dB y as the reference channel (5) for measuring the environmental magnetic noise. A differential meter (6) for measuring the / dz component and a magnetometer (7) for measuring the magnetic field components in the x, y, and z directions, and a software differential meter using the signal channel (4) and the reference channel (5) The third invention relates to a planar differential meter (3) of a signal channel (4) for measuring a biomagnetic signal and The epoxy block 9 is modularized to facilitate the replacement and maintenance of the sensor.
도 1 은 발명중 센서의 구조 사시도1 is a perspective view of a structure of a sensor in the invention
도2 는 도 1의 센서를 이용한 측정장치의 구조 개략도2 is a structural schematic diagram of a measuring device using the sensor of FIG.
* 도면의 주요부분에 대한 부호의 설명* Explanation of symbols for main parts of the drawings
1 : 검출코일 2 : 스퀴드1: Detection coil 2: Squid
3 : 평면형 미분계 4 : 신호채널3: planar differential meter 4: signal channel
5 : 기준 채널 6 : 미분계 방식의 기준 채널5: reference channel 6: differential channel reference channel
7 : 자력계 방식의 기준채널 8 : 인쇄회로 기판7: reference channel of magnetometer type 8: printed circuit board
9 : 에폭시블럭 10 : 인서트의 센서지지대9: epoxy block 10: insert sensor support
도 1 은 본 발명중 센서의 구조 사시도이고도 2는 도 1 의 센서를 이용한 측정장치의 구조 개략도인바, 이중 이완발진 스퀴드 방식의 집적화된 평면형 미분계(3) 센서를 신호채널(4)로 사용하고, 직류 인가전류방식과 직류 전단증폭기를 사용한다.FIG. 1 is a perspective view of a sensor of the present invention, and FIG. 2 is a schematic view of a measuring device using the sensor of FIG. 1, in which an integrated planar differential meter (3) sensor of a dual relaxation oscillating squid type is used as a signal channel (4). DC applied current method and DC shear amplifier are used.
신호대 잡음비를 높이기 위한 기준채널(5)로서 미분계(6)와 자력계(7)를 이용한다.The differential meter 6 and the magnetometer 7 are used as the reference channel 5 for increasing the signal-to-noise ratio.
평면형 미분계(3)가 부착된 인쇄회로 기판(8)은 쉽게 에폭시블럭(9)에 고정되며, 다채널 장치를 구성할경우 각각의 에폭시블록이 모듈화되어 센서지지대(10)로 부터 독립적으로 교체가 가능하도록 되어 있다.The printed circuit board 8 to which the planar differential meter 3 is attached is easily fixed to the epoxy block 9, and each epoxy block is modularized and replaced independently from the sensor support 10 when configuring a multi-channel device. Is made possible.
센서는 자속-전압 변화계수가 직류 스퀴드에 비해 10배이상 큰 이중이완발진 스퀴드 방식과 검출코일(1)이 스퀴드(2)와 동일 기판에 집적화된 평면형 미분계(3)를 사용한다.The sensor uses a double relaxation oscillation squid method having a magnetic flux-voltage change coefficient 10 times larger than a DC squid and a planar differential meter 3 in which the detection coil 1 is integrated on the same substrate as the squid 2.
평면형 미분계(3)는 검출코일(1) 두 개가 스퀴드(2)에 대해 좌우 대칭이 되도록 배치시키고 좌우검출코일이 직렬 연결된 1차 미분계를 채택한다.The planar differential system 3 is arranged so that two detection coils 1 are symmetrical with respect to the squid 2, and adopts a primary differential system in which the left and right detection coils are connected in series.
직류 인가전류를 사용하며 실온의 전단증폭기로 스퀴드 출력전압 신호를 직접 검출한다.Direct current is applied and the squid output voltage signal is directly detected by a shear amplifier at room temperature.
신호대 잡음비를 개선하기 위하여 기준채널(5)로서 미분계(6)와 자력계(7)를 사용한다.In order to improve the signal-to-noise ratio, the differential meter 6 and the magnetometer 7 are used as the reference channel 5.
신호채널(4)은 인체로부터 발생되는 자장신호와 외부자장을 동시에 측정하고 기준채널(5)은 외부 자장잡음만 측정하므로 신호채널(4)의 출력에서 기준채널(5)의 출력을 인위적으로 빼주는 소프트웨어 미분계를 형성함으로서 신호대 잡음비를 개선시킨다.Since the signal channel 4 simultaneously measures the magnetic field signal and the external magnetic field generated by the human body, and the reference channel 5 measures only the external magnetic field noise, the signal channel 4 artificially subtracts the output of the reference channel 5 from the output of the signal channel 4. Forming software differentials improves the signal-to-noise ratio.
평면형 미분계(3)는 인쇄회로 기판(8)에 직접 부착되고, 에폭시블록(9)에 평면형 미분계(3)가 x,y방향으로 배치되는데 에폭시블록(9)에서 인쇄회로기판(8)은 독립적으로 교체가 가능하고, 각각의 에폭시블록(9)도 인서트의 센서지지대(10)로 부터 독립적으로 교체가 가능하도록 되어 있다.The planar differential system 3 is directly attached to the printed circuit board 8, and the planar differential system 3 is arranged in the x and y directions in the epoxy block 9. Is independently replaceable, and each epoxy block 9 is also independently replaceable from the sensor support 10 of the insert.
센서방식을 이중이완발진 스퀴드 방식과 일체형 평면형 미분계로 함으로써 센서의 신뢰성을 크게 높혔고 간단한 구동회로로써 스퀴드 동작이 가능했으며, 에폭시블록(9)에 x 및 y 방향으로 각각 두개씩 배치시켜 4채널 장치를 구성하여 뇌로부터 발생하는 100fT크기의 매우 미약한 자장신호를 측정하였다.The sensor method has a double relaxation oscillation squid method and an integrated planar differential meter, which greatly improves the reliability of the sensor and enables the squid operation with a simple driving circuit.The four-channel device is placed on the epoxy block 9 in the x and y directions, respectively. We constructed a very weak magnetic field signal of 100 fT size from the brain.
[다른 실시예](변형예, 응용예)[Other Embodiments] (Modifications, Applications)
본 발명의 측정장치 방식을 신호채널(2)로서 4개의 평면형 미분계(9)를 사용하고 기준채널(5)로서 2개의 미분계(6)와 3개의 자력계(7)로 된 생체자기 측정시스템에 적용하여 성인의 심장 및 태아의 심장으로부터 발생하는 미약한 자장신호를 측정하였다.The measurement apparatus of the present invention uses a four-plane differential meter (9) as the signal channel (2) and a biomagnetic measuring system comprising two differential meters (6) and three magnetometers (7) as the reference channel (5). The weak magnetic field signals generated from the adult heart and the fetal heart were measured.
그리고 신호채널(4)의 출력에서 기준채널(5)의 출력을 적절한 비율로 빼주는 소프트웨어 미분계를 형성시킴으로서 측정된 심장 자장신호의 신호대 잡음비를 높일 수 있다.The signal-to-noise ratio of the measured cardiac magnetic field signal can be increased by forming a software differential meter that subtracts the output of the reference channel 5 from the output of the signal channel 4 at an appropriate ratio.
상기의 본 발명은 스퀴드를 이용한 생체자기 측정장치의 전자회로를 획기적으로 간단히 하고 시스템의 가격을 내리게 하고, 센서 및 시스템 동작의 신뢰성을 향상시키고, 센서의 유지보수를 쉽게하고, 신호대 잡음비를 높이는데 크게 기여한다.The present invention is to greatly simplify the electronic circuit of the biomagnetic measuring device using the squid and lower the price of the system, improve the reliability of the sensor and system operation, ease the maintenance of the sensor, and increase the signal-to-noise ratio Contributes greatly.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019980047405A KR100313480B1 (en) | 1998-11-05 | 1998-11-05 | Biomagnetic measuring device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019980047405A KR100313480B1 (en) | 1998-11-05 | 1998-11-05 | Biomagnetic measuring device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20000031388A KR20000031388A (en) | 2000-06-05 |
| KR100313480B1 true KR100313480B1 (en) | 2001-12-28 |
Family
ID=19557305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019980047405A KR100313480B1 (en) | 1998-11-05 | 1998-11-05 | Biomagnetic measuring device |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR100313480B1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100437601B1 (en) * | 2001-04-03 | 2004-06-26 | 한국표준과학연구원 | Biomagnetic measurement system using high sensitivity SQUIDmagnetometers |
-
1998
- 1998-11-05 KR KR1019980047405A patent/KR100313480B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000031388A (en) | 2000-06-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Drung | The PTB 83-SQUID system for biomagnetic applications in a clinic | |
| US7047059B2 (en) | Simplified water-bag technique for magnetic susceptibility measurements on the human body and other specimens | |
| US4613817A (en) | Superconducting gradiometer coil system for an apparatus for the multi-channel measurement of weak nonstationary magnetic fields | |
| US6418335B2 (en) | Ferromagnetic foreign body detection using magnetics | |
| US4591787A (en) | Multi-channel device with SQUIDS and superconducting gradiometers for the measurement of weak magnetic fields produced by various field sources | |
| US4346604A (en) | Electromagnetic flow probe | |
| US4937525A (en) | SQUID-magnetometer for measuring weak magnetic fields with gradiometer loops and Josephson tunnel elements on a common carrier | |
| Tsukada et al. | Multichannel SQUID system detecting tangential components of the cardiac magnetic field | |
| Ilmoniemi et al. | A four-channel SQUID magnetometer for brain research | |
| JPS6225274A (en) | Multichannel weak magnetic field measuring device | |
| JP3237590B2 (en) | Magnetic field measurement device | |
| Kajola et al. | A 24-channel magnetometer for brain research | |
| KR100313480B1 (en) | Biomagnetic measuring device | |
| JP3205021B2 (en) | Pickup coil | |
| Virtanen et al. | Biopotential amplifier for simultaneous operation with biomagnetic instruments | |
| US5381093A (en) | Magnetic resonance imaging apparatus | |
| Wikswo Jr | Cellular action currents | |
| Wikswo | Improved instrumentation for measuring the magnetic field of cellular action currents | |
| Sander et al. | A 50 channel optically pumped magnetometer MEG in an externally actively shielded two-layer room | |
| JPH05232202A (en) | Software gradiometer | |
| JPH04296663A (en) | Current measuring device | |
| US5453691A (en) | Miniaturized squid module having an intermediate super conducting support for connecting squid input terminals to gradiometer wires | |
| Drung et al. | A 37-channel DC SQUID magnetometer system | |
| Wikswo Jr | Recent developments in the measurement of magnetic fields from isolated nerves and muscles | |
| Körber et al. | Ultra-sensitive SQUID systems for applications in biomagnetism and ultra-low field MRI |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| FPAY | Annual fee payment |
Payment date: 20121011 Year of fee payment: 12 |
|
| FPAY | Annual fee payment |
Payment date: 20130906 Year of fee payment: 13 |
|
| FPAY | Annual fee payment |
Payment date: 20140929 Year of fee payment: 14 |
|
| FPAY | Annual fee payment |
Payment date: 20151006 Year of fee payment: 15 |
|
| LAPS | Lapse due to unpaid annual fee |