KR100210473B1 - Man-made hair for hair implanting and process for producing the same - Google Patents

Abstract

In the artificial hair for hair-growing according to the present invention, a biocompatible layer formed by chemically bonding collagen to a grafted polymer chain introduced on the surface of the artificial hair on the surface of the artificial hair is formed. Therefore, when the artificial hair is directly implanted into the human skin, the collagen layer 11 as the biocompatible layer fixed to the artificial hair 10 having the hair root portion 12 is the epidermis 4, the dermal layer 5, and the subcutaneous skin. Since it is integrated with the collagen in the tissue 6 and the hairy dry film 7, the artificial hair can be firmly fixed. Moreover, since down-gross does not generate | occur | produce even if time passes after planting, this artificial hair has high resistance to invasion of a pathogen, and can raise the fixation rate of the artificial hair which was planted.

Description

[Name of invention]

Artificial hair for food and manufacturing method

[Technical Field]

The present invention relates to a human hair for hair transplanting suitable for planting directly on the human skin and a method of manufacturing the same.

[Background]

There are many proposals for artificial mothers to directly plant human skin. Among them, practical applications include artificial hairs having loop-shaped hair roots developed by the present inventors (see Japanese Patent Application Laid-Open No. 3-8770, USP4793368).

2 is a cross-sectional view of the skin immediately after planting the artificial hair developed by the present inventor. The artificial hair consists of short fibers 1 such as polyester fibers, and a loop-shaped hair root portion 2 is formed in the base portion. When a special hair removal needle is engaged with the loop-shaped hair root portion 2 and inserted into the human skin, the loop of the hair root portion 2 is planted to contact the deepest part of the subcutaneous tissue 6, that is, the hairy tendon 7. . The hook 13 is for preventing the planted artificial hair from falling off.

In addition, in the figure, 3 shows keratin, 4 shows epidermis, and 5 shows dermal layer.

However, when a foreign body is inserted into the human skin tissue, the foreign body is provided with a function of forming a fibrous connective tissue to isolate the foreign body from the subcutaneous tissue. In the case of artificial hairs, after a certain period of time after hair transplantation, as shown in FIG. 3, fibrous connective tissues 8 are formed in and around the hair root portion 2. Soon, the fibrous connective tissue (8) fuses with the parental tendon (7), which is a firm connective tissue at the deepest part of the scalp, and the loop shaped hair root portion (2) of the artificial hair is beamed to the parental tendon (7). By fixing, the artificial hair can be firmly fixed to the scalp.

However, the epidermis 4 which was flat immediately after the hair transplantation as shown in FIG. 2 starts to grow downward from the portion where the artificial hair penetrates the epidermis 4 to the middle layer of the dermal layer 5 along the artificial hair. As shown in the drawing, a large hopper 9 may be formed. This phenomenon is referred to as down gross, and the skin around the artificial hairs that have been planted appears to be indented, or the sebum secreted in the hair sticks 9 accumulates and turns black and white, resulting in deterioration in appearance.

On the other hand, proposals have been made to increase the rate of fixation of the hair by attaching a material for assimilation with human skin tissue around the artificial hair to be planted (see USP3596292). That is, in this conventional example, a mesh-shaped polyurethane foam used as a human replacement material is adhered to the surface of the hair root of the artificial hair, or a hydrogel such as polyacrylic acid or polyvinyl alcohol is applied. In addition, it has been described that the layer or film of the substitute material assimilates with the subcutaneous tissue to fix the artificial hair.

In the invention of USP3596292, the assimilation of the artificial hair and the subcutaneous tissue is expected by the layer or the film of the human replacement material, but since the artificial hair and the layer or the film of the human replacement material are simply physically bonded, the human tissue is a foreign material. It is recognized that the artificial hairs are discharged by foreign matter reaction and are easily eliminated, and down gross occurs as described in connection with the invention of Japanese Patent Application No. 3-8770, and microorganisms invade from the resulting intervals. It is assumed that infection is likely to occur.

In addition, the adhesive force deteriorates due to the time-dependent change of the adhesive used for bonding between the artificial hair and the layer of the human substitute material, and the artificial hair easily falls off. In particular, in the case of the hydrogel is simply applied to the surface of the artificial hair, when inserted into the human body, the hydrogel swells, the bonding force is reduced, there is a problem that the artificial hair is easily dropped off.

In addition, in order to modify the surface of the polymer material to increase biocompatibility, the method of activating the surface of the polymer material by discharge treatment and fixing the protein has been proposed by the present inventor (see Japanese Patent Application Laid-Open No. 4-41180). .

The method of Japanese Patent Application Laid-Open No. 4-41180 activates the surface of the polymer material by discharge treatment, graft polymerizes the radical polymerizable monomer on the surface of the activated polymer material, and then surface of the graft polymer material. The protein is fixed in the However, in this method, even when looking at the base materials of Examples and the like, the sheet-like polymer material is used, and no delicate short fibers such as artificial hairs have been examined.

That is, in order to support it, the discharge treatment of plasma discharge, corona discharge, glow discharge, ionization irradiation, etc. is used for activation of the surface of a polymeric material.

However, there is a risk of deterioration of the surface of the artificial hair when the artificial hair surface treatment for the human hair is performed by discharge treatment such as plasma discharge, corona discharge, glow discharge, or the like. In the case of ionizing radiation, there is a problem that the absolute amount of generated radicals is too small. Further, in the case of such discharge treatment, it is very difficult due to the limitations of the device, such as using a vacuum device, to perform surface modification over the entire circumferential surface of the short fibers to low corners.

The present invention has a high fixation rate of artificial hair which has been planted by replenishing defects according to the conventional method, and is down. It is a first object to provide a human hair for hair growth without gross.

In addition, the present invention has a low infection rate against pathogens, a high settling rate of planted artificial hairs, and It is a second object of the present invention to provide a method for producing a human hair for growing hair without growth, by a simple and simple operation.

[Initiation of invention]

The present inventors earnestly studied in order to achieve the above object, the surface of the artificial hair in the artificial hair for hair-growing artificial hair composed of synthetic fibers such as polyethylene fiber, polypropylene fiber, polyester fiber, polyamide fiber, acrylic fiber or fluorine fiber By forming a biocompatible layer formed by immobilizing a protein by chemical bonds, it was possible to provide a human hair for hair transplantation which can achieve the above object.

That is, the bristles for human hair of the present invention is a bristles for human hair composed of short fibers of synthetic fibers such as polyethylene fibers, polypropylene fibers, polyamide fibers, acrylic fibers, or fluorine fibers, wherein proteins are fixed on the surface of the artificial hairs by chemical bonding. A biocompatible layer is formed.

The biocompatible layer is formed by fixing a protein by chemical defects through a grafted polymer chain introduced by graft polymerization of a radical polymerizable monomer such as a carboxyl group-containing monomer or a sulfonic acid group-containing monomer on the surface of the artificial hair.

In addition, the manufacturing method of the artificial hair for hair-growing of this invention is a manufacturing method of the artificial hair for hair-growing which consists of short fibers of synthetic fibers, such as polyethylene fiber, polypropylene fiber, polyester fiber, polyamide fiber, acrylic fiber, or fluorine fiber, A process of introducing a grafted polymer chain to the surface of the artificial hair, a process of chemically binding a protein molecule to the grafted polymer chain introduced to the surface of the artificial hair, and a protein molecule chemically bonded to the grafted polymer chain or added to them And a step of forming a biocompatible layer on the surface of the artificial hair by binding the protein molecules by crosslinking.

More preferably, the method of manufacturing the human hair for the hair wool of the present invention is a method for manufacturing the human hair for the hair wool consisting of short fibers of synthetic fibers such as polyethylene fiber, polypropylene fiber, polyester fiber, polyamide fiber, acrylic fiber or fluorine fiber. And introducing a grafted polymer chain to the surface of the artificial hair by irradiating electromagnetic waves such as radiation or ultraviolet rays to generate free radicals on the surface of the artificial hair in the state in which the artificial hair is immersed in a solution of a radical polymerizable monomer. Chemically bonding the protein molecules to the grafted polymer chains using a covalent or ionic bond reaction, and by crosslinking the protein molecules chemically bound to the grafted polymer chains or protein molecules further added thereto. Combine the artificial hair table To characterized in that, including a step of forming a biocompatible layer.

Typical examples of the polyester fibers in the present invention include polyethylene terephthalate fibers obtained by melt spinning polyethylene terephthalate.

Representative examples of the polyamide fibers in the present invention include linear aliphatic polyamides, that is, polyamide fibers obtained by spinning nylon 6 or nylon 66, but particularly preferably nylon 6 short fibers.

As the acrylic fiber in the present invention, a fiber obtained by spinning a polyacrylonitrile, in particular a fiber obtained by spinning a copolymer of acrylonitrile at least 50% with an acrylic acid ester, vinyl acetate, acrylamide, methacrylic acid ester and the like is preferred. .

Examples of the fluorine fiber in the present invention include fluorine fiber obtained by spinning polytetrafluoroethylene, polychlorotrifluoroethylene, tetrafluoroethylene, hexafluoropropylene copolymer, polyvinylidene fluoride and the like. However, especially short fibers based on polytetrafluoroethylene are preferable.

In order to fix the protein by chemical bonds to the surface of the artificial hair for hair-growth consisting of short fibers of synthetic fibers such as polyethylene fiber, polypropylene fiber, polyester fiber, polyamide fiber, acrylic fiber or fluorine fiber, the surface of the artificial hair is graft-modified. This can be achieved by introducing a grafted polymer chain onto the surface and chemically bonding a protein to the grafted polymer chain.

In order to introduce graft-modified polymer chains on the surface of the artificial hair by graft modification, active species are introduced to the surface of the artificial hair, and the active species is used as a starting species, and the radical polymerizability of a carboxyl group-containing monomer or a sulfonic acid group-containing monomer is used. What is necessary is just to bind a monomer by graft polymerization.

In order to generate the active species as the starting species of the graft polymerization, it is necessary to activate the carbon atoms of the carbon chain of the polymer compound constituting the artificial hair to generate radicals.

In order to generate this radical, the surface of the artificial hair may be activated by a discharge treatment such as plasma discharge, corona discharge, glow discharge, ionization irradiation, etc. Since the irradiation surface is fixed, it is technically very difficult to uniformly activate the surface of the artificial hair to every corner. Further, according to these discharge treatments, the surface of the artificial hair is roughened so that the quality of the artificial hair may be impaired.

Therefore, in particular, a method of irradiating electromagnetic waves such as radiation or ultraviolet rays that does not require treatment in vacuum is recommended. X-rays or electron beams can be advantageously used practically as radiation.

The surface modification treatment may be carried out as a pretreatment of the graft polymerization reaction. However, when the surface-modified artificial hair is taken out in air, the radicals generated by the fragmentation may be extinguished by oxidation. It is preferable to use what is called a co-polymerization method which makes a polymerization reaction.

This co-polymerization method generates radicals on the surface of artificial hair by irradiating electromagnetic waves such as radiation or ultraviolet rays while the artificial hair is immersed in a liquid containing radical polymerizable monomer such as carboxyl group-containing monomer or sulfonic acid group-containing monomer. It promotes and introduces a grafted polymer chain on the surface of artificial hair.

According to this method, radical disappearance due to oxidation after surface modification can be prevented, thereby increasing the efficiency of graft polymerization. In addition, the grafted polymer chain can be uniformly introduced into the surface of the artificial hair by irradiating light to the artificial hair in various directions or by rotating the artificial hair with respect to the light source.

However, according to the co-polymerization method, since the polymerization of the monomer proceeds simultaneously with the grafting on the surface of the artificial hair, there is a drawback that the absolute amount of the graft polymer to be formed is limited. Therefore, it is preferable to perform the graft polymerization treatment repeatedly several times. .

The graft polymerization may be performed by the presence of a deoxidizer to shorten the reaction time to improve the yield. In other words, if oxygen is present in the solution, the graft polymerization is impeded and oxygen is removed by adding an oxygen scavenger. As such deoxidant, it is preferable to use riboflavin or periodic acid.

Liroflavin or periodic acid promotes deoxygenation by light, especially ultraviolet radiation.

As the carboxyl group-containing monomer, one or two or more selected from the group consisting of acrylic acid, methacrylic acid, salts thereof and derivatives thereof may be used. In particular, acrylic acid or dimethylaminoethyl methacrylate is preferable.

The sulfonic acid group-containing monomer can be used one or two or more selected from the group consisting of acrylamide methyl propanesulfonic acid, styrene sulfonic acid and salts thereof and derivatives thereof. In particular, sodium 2-acrylamide-2-ketylpropanesulfonic acid sodium or sodium sulfonic acid salt is preferable.

In this way, in order to chemically bind the protein to the grafted polymer chain introduced on the surface of the artificial hair, a covalent or ionic reaction can be used.

The covalent reaction can be effectively used for chemical bonding of the carboxyl group and the protein of the grafted polymer chain, but not so effectively used for the chemical bonding of the sulfonic acid group and the protein of the grafted polymer chain.

In order to covalently bond the carboxyl group and the protein of the grafted polymer chain, it is necessary to first activate the carboxyl group.

The activation treatment of this carboxyl group is achieved by treating the artificial hair surface-modified by graft polymerization with an activating agent such as a carbodiimide compound or N-hydroxy succinimide to change the carboxyl group to an acid anhydride. As such carbodiimide compound, it is recommended to use 1-ethyl-3- (3-dimethylaninopropyl) carbodiimide.

When the artificial hair activated by the carboxyl group is immersed in the aqueous protein solution according to the above method, the carboxyl group, which becomes an acid anhydride, and the amino group of the protein are bonded by covalent bonds to fix the protein chemically on the surface of the artificial hair.

In the case of the ion-bonding reaction, a polyion complex reaction between the anionic group of the graft and the polymer chain and the cationic group of the protein molecule is used. To carry out this polyion complex reaction, the protein is dissolved in an acid buffer having a pH lower than 7, preferably an acid buffer having a pH of 2 to 4, so that the protein molecules are cationicized.

Immersion of the artificial hair into which the grafted polymer chain is introduced is carried out in the aqueous solution of the protein so that the anion group and the cationized protein molecule of the grafted polymer chain are firmly bound by ionic bonding, and as a result, the protein can be chemically bound to the surface of the artificial hair.

Either of the graft polymerized carboxyl group-containing monomer or the graft polymerized sulfonic acid group-containing monomer can be ionically bonded to the protein by a polyion complex reaction, but the sulfonic acid group-containing monomer is preferred from the strength of the bond and the ease of reaction. Do.

In this way, artificial hairs with chemically bound proteins on the surface can be used practically as hair-growing artificial hairs. However, when the artificial hairs are planted, they are subject to degradation by enzymes in the body for a long time in skin tissues. For this purpose, it is preferable to crosslink and firmly bind proteins fixed on the surface of the artificial hair.

The crosslinking of the protein may use a photocrosslinking reaction by ultraviolet irradiation or a chemical crosslinking reaction using a reaction accelerator such as glutaraldehyde or formarin. The crosslinking of the protein may also include crosslinking between the protein chemically bound to the artificial hair and a protein molecule additionally added thereto, in addition to the crosslinking between the proteins chemically bound to the artificial hair.

As a specific method of protein crosslinking, when a photocrosslinking reaction is used, a synthetic hair immobilized on the surface of the protein is immersed in an aqueous protein solution as needed, then pulled up and dried, and irradiated with ultraviolet rays to crosslink the protein. Can be.

In the case of using a chemical crosslinking reaction, the artificially immobilized protein is immobilized in an aqueous protein solution as needed, then pulled up and dried, and then immersed in an aqueous solution of formarin or an aqueous solution of glutaraldehyde. After several hours of gentle stirring at a relatively low temperature, the crosslinking of the protein is completed, so it is taken out, washed and dried.

In particular, in the case of graft polymerization by the co-polymerization method, it is relatively difficult to increase the absolute amount of the immobilized protein. Therefore, it is preferable to simultaneously crosslink the additional protein at the time of crosslinking of the protein. According to this method, the film thickness of the protein immobilized on the surface of the artificial hair can be thickened, and when the artificial hair is implanted into the human skin, it can be made to have a strong resistance to destruction by enzymes in the body.

In the case of graft polymerization by co-polymerization by UV irradiation, it is possible to introduce the grafted polymer chain uniformly on the surface of the artificial hair without damaging the surface of the artificial hair with an inexpensive device. An immobilized biocompatible layer can be formed.

Examples of the protein used in the present invention include collagen, denatured collagen gelatin, fibronectin, and other cell-adhesive proteins. From the viewpoint of biocompatibility, collagen, the main component of skin tissue, is most preferred.

The grafted polymer chain bound to the surface of the artificial hair has a large size and is very compatible with the polymer compound constituting the artificial hair. Therefore, the protein bound through the grafted polymer chain is fused to the polymer compound constituting the artificial hair. Since it rarely disappears, the protein can be semipermanently retained on the surface of the artificial hair.

In this way, the surface of the artificial hair in which the protein is fixed by chemical bonding has a function as a physiologically active surface, and when it is implanted into the human skin, the surface of the artificial hair 10 having the hair root portion 12 as shown in FIG. The biocompatible layer 11 made of the immobilized protein is assimilated with proteins in the epidermis 4, the dermis layer 5, the subcutaneous tissue 6 or the hair dry tendon 7 to be firmly fixed to the artificial hair 10. can do.

In addition, since the artificial hair is fixed to the living tissue as a whole through the biocompatible layer, there is no gap between the biological tissue and the artificial hair, thereby preventing down-gloss of the epidermis and infection due to invasion of pathogens in this gap.

[Brief Description of Drawings]

1 is a cross-sectional view showing a state after a certain time has elapsed after weaving the artificial hairs for weaving of the present invention.

2 is a cross-sectional view showing a state immediately after planting a conventional artificial hair.

3 is a cross-sectional view showing a state after a predetermined time has passed since the conventional artificial hair is planted.

Best Mode for Carrying Out the Invention

Embodiments will be described in order to explain the present invention in more detail.

Example 1

[Surface Modification of First Step Artificial Hair]

A 9 kV corona discharge is irradiated to the surface of an artificial hair made of short fibers of polyamide fiber (nylon-6) for 2 minutes, and a peroxide is introduced into the surface of the artificial hair.

[2nd step graft synthesis]

The surface-modified artificial hairs are soaked in 10% by weight aqueous acrylic acid solution. 50 while fully degassing After heating for 1 hour, the acrylic acid monomer is graft-polymerized on the surface of the artificial hair.

[Step 3 Removal of Homopolymer]

70 graft polymerized artificial hair Water was passed through for 15 hours to remove homopolymers formed in the second step.

[Activation of the 4th step carboxyl group]

Concentration 10 Of Aqueous solution of 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide (pH = 4.5, liquid temperature 4) Soak for 10 minutes.

[Covalent Bond of Step 5 Collagen]

Concentration of artificial hair treated in the 4th process is 0.5 Of , Temperature 4 It is immersed in the aqueous solution of collagen (collagen type I by Niida gelatin Corporation) for 2 hours.

[Step 6 Cleaning]

The artificial hair which passed through the 5th process is taken out, and it wash | cleans in HC1 solution of pH3.0, and also wash | cleans with a storage water again.

[7th step crosslinking of collagen]

The collagen fixed artificial hair obtained in the 6th process was replaced with a self-circulating lamp (15W, 254 Check by). The photocrosslinking reaction is completed in about 12 hours when the artificial hair is rotated to every corner while rotating the artificial hair, and the artificial hair with the collagen is firmly obtained.

The fixed amount of collagen in the bioactive surface of the artificial hair thus formed was 8.1 Of It was.

Example 2

[First Step First Graft Polymerization]

Ribopulabine 20 in 1 wt% aqueous solution of dimethylaminoethyl methacrylate in a test tube made of quartz Inject the solution added, immerse the artificial hair made of short fibers of polyethylene terephthalate fiber therein, inject nitrogen gas for 30 seconds, and then plug the stopper.

While rotating this test tube, it revolves around the center of the light source which generate | occur | produces an ultraviolet-ray, and irradiates an ultraviolet-ray for 2 hours. As the graft polymerization proceeds, the viscosity of the solution rises.

In this step, the permeability of dimethylaminoethyl methacrylate to the artificial hair is strong, so that the polymer compound in the portion which is slightly inside the surface of the artificial hair can be graft-polymerized.

Second Step Second Graft Polymerization

Next, riboflavin 20 was added to a 5% by weight aqueous solution of acrylic acid in the quartz test section. The artificial hair graft-polymerized in the 1st process was immersed in the solution which added this, and the ultraviolet-ray is irradiated for 2 hours, rotating and revolving the test tube which stopped the stopper by blowing in nitrogen. As the graft polymerization proceeds, the viscosity of the solution rises.

This process is mainly carried out to neutralize the anion dissociated in the first step while graft polymerization on the surface of the artificial hair.

[Step 3 Removal of Homopolymer]

In the first and second steps, homopolymers of methacrylic acid and acrylic acid are generated, but since the homopolymers are hindered by covalent bonding of the next step, the artificial hair treated in the second step to remove these homopolymers is removed. About 70 Water for 15 hours.

[Activation of the 4th step carboxyl group]

10 of 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide for activating the carboxyl groups of the poly atry or polymethacrylic graft chains produced by graft polymerization Of Solution (pH = 4.5, liquid temperature 4 Soak for 10 minutes.

[Covalent Bond of Step 5 Collagen]

Synthetic hair treated by the fourth step collagen (collagen type I made by Niida gelatin Co., Ltd.) 1 Of Aqueous solution (20 After soaking for 1 to 2 hours, collagen is immobilized on the surface of artificial hair by covalent bonding with carboxyl group introduced by graft. After completion of the reaction, the artificial hairs were taken out and washed with HC1 solution having pH = 3.0, washed with distilled water and dried at room temperature.

[Sixth Step Collagen Crosslinking]

Glutaraldehyde 12.5 Dissolved in phosphate buffer (pH7.4) or distilled water (pH6.0) to a concentration of 200 mM, 4 To keep. Into this glutaraldehyde solution, the collagen immobilized artificial hair obtained in the fifth step was immersed. Crosslinking board is performed for 24 hours, stirring gradually at. After the reaction, the mixture is washed with distilled water and dried at room temperature.

The amount of collagen fixed on the bioactive surface of the artificial hair thus formed was 16 Of It was.

Example 3

[Step 1 Graft Polymerization]

Aqueous solution of 10% by weight sodium 2-acrylamide-2-methylpropanesulfonate 70 4 in Add riboflavin to 1 /. After inserting the polyester fiber into the test tube into which the monomer solution was injected, nitrogen gas is blown for 30 seconds and the stopper is closed. The tube is irradiated with ultraviolet rays for 2 hours while rotating and revolving.

[Step 2 Homopolymer Removal]

In order to remove the homopolymer of sulfonic acid, the grafted artificial hair obtained in the first step is washed with hot water at 70 ° C for 15 hours.

[Section 3 Collagen Fixation]

Collagen aqueous solution (collagen made by Niida gelatin Formula I Type pH3, HC1) 0.5 Of Is taken into a test tube, and the grafted artificial hair obtained in the second step is dipped therein. When left overnight at room temperature, collagen is immobilized on the surface of the artificial hair by an ionic bond reaction. The artificial hair is taken out, washed with hydrochloric acid, washed with distilled water and dried at room temperature.

[4th Step Collagen Crosslinking]

1.5% artificial hair fixed with collagen on the surface obtained in the third step Of Soak in collagen aqueous solution (pH3.0), dry, and heat for 12 hours at room temperature. Rotate the artificial hair with) to irradiate every corner and cross-link collagen.

In addition, this artificial hair 3 Of Soak in collagen aqueous solution (pH3.0) and dry, and UV lamp (15W, 254) at room temperature for 24 hours. By irradiating to every corner while rotating the artificial hair with), the artificial hair with which collagen was firmly fixed to the surface is obtained by crosslinking collagen.

The fixed amount of collagen at the physiologically active surface of the artificial hair thus formed was 35.6 Of It was.

[Industry availability]

As described above, the artificial hair for hair-growing of the present invention has a biocompatible layer in which proteins are chemically bonded to the surface of the artificial hair made of short fibers of synthetic fibers such as polyethylene fiber, polypropylene fiber, polyester fiber, polyamide fiber, acrylic fiber or fluorine fiber. Since the epidermis, the dermis layer, and the subcutaneous tissue adhere to the protein layer on the surface of the artificial hair transplanted after the seeding, and the sperm period passes after the seeding, the fibroblasts are assimilated with the protein produced therefrom.

Therefore, when the artificial hair is directly implanted into the head of the living body, mainly the human head, the bioactive layer can be combined with the subcutaneous tissue to prevent the artificial hair from falling off for a long time.

In this way, the infection rate against P. aeruginosa is low, the settled rate of planted artificial hair is high, and It is possible to provide a human hair for the hair removal without the gross.

Claims (14)

In a human hair for human hair composed of short fibers of synthetic fibers such as polyethylene fiber, polypropylene fiber, polyester fiber, polyamide fiber, acrylic fiber or fluorine fiber, a biocompatible layer is formed on the surface of the artificial wool to fix proteins by chemical bonding. Artificial hair for hair removal, characterized in that. The method of claim 1, wherein the biocompatible layer is a compound in which the protein is fixed by chemical bonding through a graft polymerized chain introduced by graft polymerization of a radical polymerizable monomer such as a carboxyl group-containing monomer or a sulfonic acid group-containing monomer on the surface of the artificial hair Characteristic artificial hair for hair removal. A method for producing a human hair for artificial hair composed of short fibers of synthetic fibers such as polyethylene fiber, polypropylene fiber, polyester fiber, polyamide fiber, acrylic fiber or fluorine fiber, the step of introducing a grafted polymer chain on the surface of the artificial wool, Chemically bonding protein molecules to the grafted polymer chains introduced on the surface of the artificial hairs and crosslinking the protein molecules chemically bound to the grafted polymer chains or protein molecules additionally added thereto by crosslinking A method of manufacturing artificial hair for a hair transplant comprising the step of forming a biocompatible layer on the surface. The method of claim 3, wherein as a method of introducing a grafted polymer chain to the surface of the artificial hair, free radicals are generated on the surface of the artificial hair in a state in which the artificial hair is immersed in a solution of a radical polymerizable monomer such as a carboxyl group-containing monomer or a sulfonic acid group-containing monomer. A method of manufacturing artificial hair for a weaving hair, characterized by irradiating electromagnetic waves such as radiation or ultraviolet rays. 5. The method of claim 3 or 4, wherein the step of introducing the grafted polymer chain onto the surface of the artificial hair is carried out in the presence of an oxygen scavenger. The method for producing a human hair for hair removal according to claim 5, wherein riboflavin or periodic acid is used as the deoxidizer. The method for producing a human hair for hair removal according to claim 3 or 4, wherein one or more selected from the group consisting of acrylic acid, methacrylic acid, salts thereof and derivatives thereof is used as the carboxyl group-containing monomer. . The method of claim 3 or 4, wherein one or two or more selected from the group consisting of acrylamide methyl propanesulfonic acid, styrene sulfonic acid and salts thereof and derivatives thereof is used as the sulfonic acid group-containing monomer. Method of manufacturing artificial hair. The method of claim 3, wherein a covalent bond reaction is used as a method of chemically binding a protein to the grafted polymer chain. The method of claim 9, wherein the grafted polymer chain is activated with an activator such as a carbodiimide compound or N-hydroxysuccinimide to promote the covalent bond reaction. Way. The method of claim 3, wherein the ionic bond reaction is used as a method of chemically binding a protein to the grafted polymer chain. 12. The method of claim 11, wherein the reaction solution Ph of the grafted polymer chain and the protein is adjusted to 2 to 7 in order to promote the ionic bond reaction. The method of manufacturing a human hair for a weaving hair according to claim 3, wherein a photocrosslinking reaction by ultraviolet irradiation or the like is used as a method of binding the protein molecules by crosslinking. 4. The method for producing a human hair for hair removal according to claim 3, wherein a chemical crosslinking reaction using glutaraldehyde, formarin, or the like as a reaction promoter is used as a method of binding the protein molecules by crosslinking.