KR0165891B1 - Bipartite injector device - Google Patents

Abstract

Front closed end, rear open end, cylindrical cylindrical inner wall, hub, bore, sheet, tube, long hollow outer shell with snap-fit locking assembly, inner end with front end, coaxially mounted tubular spike and rear end A eve containing a cylindrical vial at the open end of the shell, the cylindrical vial having an open end that is slidable and closed to the stop, the stop configured to be connected to and maintained in the socket A binary syringe device having a projection, the sharp end of the spike being formed to penetrate the stop.

Description

Dual syringe device

Figure 1 is a schematic cross-sectional view of a large binary injection device according to an embodiment of the present invention connected to the drug vials.

2 and 3 are enlarged fragmentary cross-sectional views of the FIG. 1 device showing the sleeve snap-fits to the shell.

Figure 4 is a schematic cross-sectional view of a small binary injection device according to another embodiment of the present invention connected to the drug vials.

Figures 5 and 6 are similar to Figures 2 and 3 but showing the snap fit of the sleeve to the shell of the Figure 4 device.

7 is a schematic exploded view of a syringe mixer and injection device in accordance with an embodiment of the present invention, showing a syringe and an adapter respectively associated with a medication vial.

FIG. 8 is a schematic diagram of FIG. 7 device showing a syringe and an adapter connected to each other and associated drug containing vials for filling the vials associated with the adapter to the vials associated with the syringe via the adapter and syringe.

* Explanation of symbols for main parts of the drawings

1: two-way syringe device 2: shell

5: hub 6: bore

11, 43: ring 20: sleeve

26: recess 32: needle

33: flange 34: socket

40: vial 42: stop

The present invention relates to the combination of a binary syringe device, a syringe mixer and a binary syringe.

Many syringe mixers and / or syringe structures are known in the art, and some are simple ribs, as disclosed in US Pat. No. 3,563,763 to Paulson and US Pat. No. 3,570,486 to Engelsher et al. And interconnects of grooves or components. Similar to Burke's US Patent No. 3,523,531 and White No. 4,411,163 are disclosed. However, prior art devices were not only inexpensive to manufacture, but also had a combination that could not provide accurate component arrangements and fluid tightness of interconnects. Prior art devices also pose the risk of accidentally stabbing the skin by the user.

For example, Smith, US Pat. No. 2,490,552, discloses a syringe with a single hollow needle that has an opposite pointed end and is axially movable, which needle and needle may be used to allow the syringe to be used. It is arranged so that the pointed end inside penetrates the seal to flow-connect the prefilled chemical chamber, but in a gentle and inconvenient manner, the user presses the exposed pointed end, exposing not only the risk of contamination of the drug, the user and the environment. Pushing the needle into the seal against the seal presents a risk of other injuries or accidental punctures.

Ogle U.S. Pat. In the neck of the vial having the plug and the liquid filled with the ram and pressurized by the ram against the plug until the liquid is stabbed by the needle, it passes through the needle beyond the stop and mixes with the powder, Instead of needles for vial removal, syringes and vials can be equipped with a vial and luer lock connection using a bypass plug that allows the liquid to be powdered when pressurized by the ram. Is used with distribution needles with corresponding luerlock connections.

Inconveniently, the structure of these Ogle patents is complex, expensive and requires many other precise interfit components, thus without leaking the internal hydraulic pressure generated during operation of the viram to deliver liquid to this syringe. It must be supported.

Kofer's U.S. Patent No. 4,516,967 shows a medicament liquid filling syringe in which the needle is pushed through the seal of the medicinal powder filling vial, where the liquid enters the vial from the syringe to be mixed with the powder, The mixture is then sent back into the syringe and requires gentle and inconvenient bidirectional liquid delivery to mix and prepare for injection.

US Pat. No. 4,619,651 to Copper et al. Discloses a syringe delivery system similar to that of Ogle and Copper, wherein the needle is attached by a luer lock connection, the double seal of which the neck forms an intermediate holding chamber. Branches are used with special type vials.

Ogle's U.S. Patent No. 3,542,023, Rinser et al. Various examples of similar syringes with single fast hollow needles with opposing pointed ends are illustrated.

Green U.S. Patent No. 4,648,532 has a front nozzle and a rear ram, including a liquid filling brace inside the nozzle, and when the rod is pushed into the nozzle to drill a brace, the released liquid mixes with the powder. This allows the ram to drive the mixture out through the nozzle.

It is a further development than the prior art to provide a syringe device in which the parts are easily assembled using a snap-fit device. This provides a low cost of assembly and assembly of parts that can be precisely arranged and provide watertight connections, but can be separated into several parts. For many types of syringes it is important that the parts cannot be inadvertently separated from each other. This is especially true if the drug being handled is harmful to the person administering it. In some prior art devices, parts to be sealed in contact with each other are moved relative to each other by transport and handling of the syringe prior to use to break the seal. In other cases where the seal may be inadvertently broken, the syringe plunger may be retracted slightly relative to the outer shell of the syringe, resulting in drug leakage or contamination. For this reason, at least in some cases the parts are permanently held together. This greatly increases the cost of the syringe, which is undesirable.

Detachable parts for transferring the drug liquid from the filling vial to the drug solid or liquid in the receiving vial so that the syringe mixer and the syringe device are easily and quickly mixed in a safe and sterile state without being re-delivered to the filling vial. If the parts associated with the provided and filled receiving vials are capable of being separated and connected without modification of the dispensing device, they are more advanced than in the prior art.

It is an object of the present invention to overcome or alleviate one or more of the difficulties or drawbacks of the prior art.

According to a first aspect of the present invention, a binary syringe device is provided, which includes a long hollow outer shell and a garden cylindrical inner sleeve, the outer shell having a front closure end, a rear open end, and a shell inside. A cylindrical cylindrical inner wall forming a chamber, a hub coaxial with the inner wall extending through the closing end from the chamber to a forward point outside the shell, a bore extending through the hub, the bore within the chamber A first portion of an enclosing coaxial sheet, a tube formed by a hub end outside the shell, and a snap-fit lock assembly formed on an end of the inner wall near the closing end, wherein the inner sleeve is mounted forwardly, coaxially A tubular spike, and a rear end, wherein the inner sleeve is fastened to the first portion to mount the inner sleeve to the chamber in a cantilever manner. And a second portion of the snap-fit locking assembly is formed on the inner sleeve front end, the front end having sealing means for sealingly engaging the sheet when the sleeve is operably mounted. Wherein the spike is rearward and has a sharp end ending sufficiently inward of the rear open end of the outer shell to prevent inadvertent contact with the human, and a coaxial flow passage through the spike and the inner shell Extends, the radial outer diameter of the sleeve is smaller than the diameter of the inner wall such that an annular space is formed between the inner wall and the sleeve when the sleeve is operably mounted to the shell, the sleeve being It has a connecting socket at the rear end, and the spike protrudes into the socket. The syringe device is adapted to receive a cylindrical drug vial at the open end of the shell, the vial having a hollow cylindrical wall having a wall thickness less than a radial distance to the sleeve, The vial is slidable with respect to the shell and is guided to move by interaction with the wall and the sleeve or any one of which the vial has an open end closed by a penetrable stop The stop is provided in the socket and has a protrusion shaped to be connected to the socket, the stop being axially slidable within the vial, the spike being operated by the vial to the syringe device. Between the vial and the tube through the spike, flow passage and bore when Its sharp tip to provide a mill flow is configured to pass through parts of the still.

The two-part snap-fit lock assembly is preferably formed by a radially inward shrinkage ring formed near the front end of the inner wall and a radially outward locking flange on the front end of the sleeve, the flange being snap-locked with the shrink ring. The sleeve is cantilevered to the shell.

A two-way syringe device according to the first feature comprising a sleeve cantilevered to the shell for watertight flow of a medicament between an outer shell and a vial connected to one end of the device and a tube of the other end of the device. Again it can be connected to a separate filling, mixing or dispensing device. Such binary syringe devices can thus be made of conventional materials and components and assembled in a simple and inexpensive manner. In addition, the needle is protected from unintended contact with humans since the spike ends inward from the inner sleeve outer end.

The shell has an approximately radial front wall that defines its closed end, and the sleeve front end is preferably arranged to abut the wall when the rim and groove are locked.

The spike is in the form of an elongated needle with a front collar flange, and the sleeve has a coaxial needle mount that attaches the needle to the sleeve in a watertight manner.

In a preferred embodiment of the present invention, the needle mounting portion has a central circular recess facing forward at the front end of the sleeve, a central circular extension facing backward, and a passage extending from the recess to the extension, wherein the recess , The extension and the rim are coaxial. The collar flange is arranged to be coaxially mounted on the extension, and the recess is arranged to receive the sheet coaxially. The needle mount has connecting means and the collar flange has corresponding connecting means for connecting the needle to the sleeve in the extension.

The sleeve is radially directed from its front end towards its extension to form a concentric compression compensation space to help the local compression displacement of the rim for snap fit locking in the groove through the ring. It may have an annular depression extending.

In an alternative embodiment of the present invention, the needle mounting portion has a central circular hollow concave portion with a circular shoulder portion, the formation portion, the shoulder portion and the rim being coaxial, the formation portion and the shoulder portion receiving the collar flange and The collar flange is sized to engage the recessed portion surrounding the collar flange and the shoulder portion is positioned axially so that the flange is mounted directly on the sheet.

The recess is a large diameter central round neck facing forward at the front end of the sleeve, which is constrained outward by an anterior thin wall neck extending rearward from the sleeve flange, and a thick back extending from the neck. The wall shank portion may be constrained outwardly and may include a small diameter central circular shank recess facing rearwardly separated by the shoulder portion. The shoulder portion is arranged to position the collar flange to the rear of the foremost neck limit, and the neck portion is sized to assist the compression displacement of the rim to be locked in the groove through the ring.

The shell has a nozzle that constrains the tube outwardly at its closing end and, in use, is connected to an independent filling, mixing or dispensing device to provide watertight flow between the vial and the independent device through the needle and tube. The nozzle may have a luerlock connection for engaging the mating luerlock connection so as to be releasably interconnected on a separate device. The socket may have a thread for engaging the thread on the vial stop.

Preferably, the shell and the sleeve are made of plastic, for example formed of injection molded parts, for the snap-fit cantilevered connection to provide a binary device, the needle being made of metal.

Snaplock cantilever mounting devices that mount the sleeve to the shell are important to allow the spikes or needles to be mounted substantially firmly axially within the shell. Thus, when the vial is operably inserted into the open end of the shell, the sharp tip contacts the penetrating barrier of the stop. This is important in emergencies and to avoid waste, and also important because the spike tip is inside the rear end of the shell and therefore the user cannot guide the stop to engage the spike end.

According to another feature of the present invention, there is provided a syringe mixer and a binary syringe device comprising the two-way syringe and the adapter, wherein the syringe and the adapter are lengthwise from the front end to the rear open end and from the front end to the rear end, respectively. A protected fluid passage extending in a direction, the binary syringe includes an external nozzle at its front closure end, and the adapter includes a mating connection nozzle defining an internal boundary of the passage at its front closure end And the outer nozzle and the mating connection nozzle are arranged to releasably interconnect the syringe and the adapter to flow-connect the passage in a protected watertight condition, the adapter extending from the rear open end toward the front closed end and Receives a cylindrical medicine vial having an upper end closed by a penetrating stop in use and It has a guide passage suitable for guiding relative movement with respect to it, and has a connection socket at a rear open end suitable for fixedly connecting the stop and a socket from the rear open end to prevent protruding into the socket and inadvertently contacting a human being. And a tubular spike that ends in the interior and flows through the stop to flow-tightly communicate the vial with the passage.

The syringe mixer and syringe device function as follows. In each socket, a concave tubular spike, when connected to the socket, passes through the stop of the vial and the syringe connection vial is filled with the contents of the adapter connection vial. Then, the syringe nozzle is disconnected from the adapter nozzle and directly connected without modification to the dispensing device having a connection nozzle similar to the adapter nozzle.

The device can be used in combination with a receiving vial filled with a solid or liquid medicine and with a filling vial filled with a liquid medicine for one-way delivery to the receiving vial and not mixed with the medicine therein without being re-delivered to the filling vial. It can be used without inadvertent skin penetration or other injury to the user by exposed needles, and also without contamination of the drug, the user or the environment.

The device can be provided in a compact, storeable form that can be simply and inexpensively manufactured with conventional materials and ingredients and allows for fast and safe administration of a predetermined amount of two separate agents which are immediately mixed when used under improved sterilization conditions. Function.

Preferably, the nozzle and counterpart nozzle have a mating luerlock connection for releasably interconnecting the syringe and the adapter.

In particular, each socket defines an axial cylindrical recess and each spike defines an axial hollow cylindrical tubular portion disposed coaxially with the respective recess. Each spike is preferably cantilevered and has a sharp free end and a base integrated with the proximal end of the corresponding end of the syringe and adapter through which each passage extends. In addition, each socket preferably has an internal threaded connection suitable for engaging with a mating external threaded connection on the stop of the corresponding vial to be connected thereto in use.

The shell and sleeve of the binary syringe device and the adapter are formed from plastic injection molded parts.

Very importantly in this aspect of the invention, no part of the spikes need to be made of metal, which is sufficient to penetrate the stops made of material such as ordinary rubber or the like on the vias easily and quickly. This is important in the case of short, sharp spikes made of plastic in that they are not sharp enough to show the danger of penetrating the user's skin.

Moreover, in the manufacture of plastic spikes, there is no need for the effort and expense of being integrated into the syringe and adapter and providing a separate needle for connecting with the syringe and other parts of the adapter, for example by a staking technique, and through the vial stop. It is not necessary to cut or grind the metal needle outer end so as to sharpen the needle outer end, and to wash the needle to remove undesirable metal particles generated during cutting or grinding before the staking.

In addition, short plastic spikes can be formed integrally in the vicinity of the syringe and adapter so that they are more robust and more precisely centered within tolerances that can be controlled by, for example, an injection molding process, and The stop bore is more coaxially aligned with the stop bore of the vial so that the stop is easily, quickly and securely attached to the socket, without causing misalignment.

In contrast, a syringe unit with a metal needle is not assembled in a perfectly centered configuration to engage the stop bore of the associated drug vial, and thus into the socket of the syringe unit containing an unaligned needle. When screwed in, the needle is unable to meet the center of the stop. Once off the center, as the vial stop is rotated into the socket, the needle is buried into the thick sidewall of the stop so that it is not in fluid connection with the vial contents, thereby making the syringe unit inoperable and making emergency injections. Results in a poem that should not happen. Using additional force to attempt a fluid connection breaks the vial and hurts the user's hand.

When the syringe and the adapter of the device according to the invention are interconnected, the spike is connected to an adapter whose base end is shaped, for example, on the remainder of the syringe and the adapter, which is firmly supported and forms a socket with the corresponding outer end of the syringe. An internally fasting, sharp free-ended cantilevered tubular extension that is completely permanently received within the boundaries of the surrounding barrel formed by it will be formed within the socket. The vial is a medicament (P), for example a vial filled with a predetermined dose of liquid, such as sterile water, and a compatible medicament (P), for example, soluble in the medicament (L) of the vial. Other liquids or solids that need to be administered safely and sterile may be standard known types of vials filled with a predetermined dosage, such as micropowders or tablets such as emergency medicine.

Thus, the device according to this aspect of the invention can be used as a two-room mixing and injection system of manually operated liquid-liquid (wet-wet) or liquid-solid (wet-dry powder) which achieves the above-described object. have. It is particularly useful for mixing the drug by one-way delivery from the filling vial to the plunger vial, without re-delivery to the filling vial, but instead only mixing in the plunger vial, for example by simple manual stirring.

Vials associated with syringes and adapters are disposed of as pre-assembled units with syringes and adapters with protective caps (not shown) removable on these outer ends, and similar caps are provided with the open ends of two vials. Possible disposable sterile products, such as first aid equipment, may be prepackaged in small size.

It opens the package, removes the cap, pushes the vial into the syringe and adapter for delivery and mixing, removes the filled plunger vial and syringe from the adapter and filling vial, and attaches the standard dispenser. The step eliminates the need for the user to contact toxic or dangerous drugs or substances, expose the needle needle, or modify the syringe to accommodate the standard dispenser, and handles them quickly and easily with minimal contamination of the sterile drug or environment. do.

A well-designed one-way, one-step delivery and mixing system is safer to use than a conventional system, and because delivery and mixing takes place in a completely closed two-room device, from start to finish, the user is never left with an unprotected needle. It is not exposed and there is no need to bend the needle from the syringe for attachment of a separate dispensing device.

The risk of injury when working with devices with exposed needles is that there are many opportunities for exposure to contaminants such as HIV (human immunodeficiency virus) and AIDS (acquired immunodeficiency syndrome) in today's hospital and home care settings. Is even more serious.

The invention will be explained in more detail with reference to the accompanying drawings. The following detailed description, however, is merely illustrative and does not limit the overview of the invention described above.

With reference to the drawings, referring first to FIG. 1, a binary syringe device 1 is shown, which is longitudinal, for example a cylindrical hollow outer shell 2 and a cylindrical inner sleeve 20, an apparatus ( At the rear end of 1) it comprises a conventional cylindrical powder or liquid drug containing vials in the form of plunger vials 40. The device is connectable to the front end of the device 1 and can be used with an adapter with its own pharmaceutical liquid containing filling vial (not shown) which is described in more detail with reference to FIG. 7 below.

The shell 2 has a front closure end 3, a circular rear open end 4 and a circular center hub 5. The hub 5 extends through the closing end 3 inside the shell, for example, from the inclined outer circular tube 5a to the inclined inner circular sheet 5b, and from the tube 5a to the sheet 5b. It has a central bore 6 extending into the furnace. The outer nozzle 7 encloses the tube 5a at the closed end 3 from the outside and has a separate device, such as a syringe needle (not shown), or a filling device having a corresponding connection such as a water lock. It has a recess 8 with a conventional luer lock, such as a female luer lock 9 for connecting the nozzle 7 to a filling device formed by an adapter connected to a vial.

The cylindrical inner wall 10 of the shell 2 forms an interior coaxially receiving the guide via 40 through the end 4 for relative longitudinal and rotational movement, and the opening of the guide via 40. The tip 41 is closed by a movable cylindrical needle-through stop 42 with a ring 43 for sealing the contents of the powdered medicine P, for example.

The inner wall 10 is defined axially between the circular shrink ring 11 radially inward near the closing end 3 and the radial front wall 13 forming the ring 11 and the closing end 3. It has a radial and inward circular locking groove (12). The ring 11 is hollow and is formed of a conical inserting inclined portion 11a at an angle of about 30 degrees, a hollow cylindrical cylindrical span 11b, and an opposing hollow and conical locking inclined portion 11c at an angle of about 45 degrees. .

The wall 10, the ring 11, the groove 12, and the sheet 5b are circular sections, concentric and coaxial, and the bores 6 extend along the central axis of the shell 2.

The rear end 4 is used to keep the device 1 sterile before use with the lateral flange 14 and the vial 40 formed as finger gripping portions to assist in handling the device 1 in use. It is provided with a groove forming portion 15 for receiving a sterile friction fitting closure cap (not shown). A similar cap (not shown) protects the tube 5a and the nozzle 7 at the front end 3.

The sleeve 20 has a front cantilever mounting end 21 and a rear free end 22. The front end 21 has a ring 11 for connecting the front end 21 of the sleeve 20 to the front end 3 of the shell 2 in a circular compression rim 24 at its periphery. And a radially outwardly circular flange 23 arranged in a size cooperative with the grooves 12. The front end 21 is an obliquely inclined concave portion 26 facing forward communicating with a central inclined extension 28 facing backward through the annular depression 25 and the central inner passage 27. Has

The depression 25 is located radially between the flange 23 and the recess 26, and provides a local compression displacement of the rim 24 through the ring 11 for snap fit locking in the groove 12. It extends from the front end 21 toward the extension 28 to form a concentric compression space. The recess 26 is arranged to receive the sheet 5b of the hub 5 in a watertight manner so as to communicate the bore 6 and the passage 27. The remainder inside the sleeve 20 in the extension 28 forms an annular space 29 in the rear cylindrical extension 30 having an internal thread 31. Hollow needle 32, for example, an extension 30 in annular space 29 to communicate with passage 27 with a prescribed standard oblique angle (non-D. V. 166A × 1½) metal needle. It is arranged in the cylindrical extension portion 30 together with the externally threaded forward circular inclined color flange 33 mounted in a watertight manner on the central extension portion 28 via the inner thread thread 31 on the upper portion. This mounting allows the rear sharp end of the needle 32 to be coaxially within the socket 34 within the rear end 22 of the remote portion of the extension 30 and within the socket circular outer wall 36. Located in the center of the thread (35).

Rim 24, space 25, recess 26, extension 28, space 29, extension 30, socket 34 and outer wall 36 are circular cross-sections, concentric and coaxial The passage 27 extends along the central axis of the sleeve 20.

The recess 26, the central extension 28, the space 29 and the cylindrical extension 30 provide a central needle mount between the rim 24 and the socket 34, so that the rim 24 has a groove ( When tightly locked in 12, the recess 26 is automatically and firmly seated relative to the sheet 5b, and the threads 31 which are selectively and automatically adjustable fastening to the threaded color flange 33 are The needle (33) to automatically and securely seat the flange (33) relative to the extension (28) for watertight flow between the needle (32) and the tube (5a) via the passageway (27) and the bore (6). 32).

Preliminary positioning of the taper and threaded color flange 33 and needle 32 per thread 31 for the seat 5b, recess 26, extension 28 and color flange 33 By means of this, the rim 24, the ring 11 and the groove 12 are adapted to a size and position where the sleeve 20 can be firmly snap-fitted to the shell 2. And the watertight connection of the sleeve 20 is assuredly ensured.

As shown in FIGS. 2 and 3, the rim 24 is precisely sized to compressively displace through the ring 11 and snap-fit in the groove 12, so that the sleeve 20 may be inexperienced. Can be easily connected to the shell (2). Since the two pieces move together in such a manner that they are gradually inserted by a manual force using a simple jig, the rim 24 is pressed against the inclined insertion portion 11a having a low inclination of 30 degrees, and the sleeve 20 is pushed. Due to the inherent elasticity of the material, such as plastic, to make, with the aid of the space 25 which compensates for the internal radial transient deformation of the rim 24 and the flange 23, movement into and across the cylindrical span 11b This is facilitated.

When the rim 24 reaches the lock inclined portion 11c of the steep inclination of 45 degrees, the snap fit movement into the groove 12 is easy. As shown in FIG. 1, since the loaded compressive force is rapidly released along the inclined portion 11c as the rim expands to its original radial dimension and is firmly and securely fastened to the groove 12, the flange 23 By matching the front end 21 of the sleeve 20 to the corresponding inner shape of the front end 3 of the shell 2 at the radial wall 13 and fitting these parts to the appropriate size and shape, Under the snap-fit cantilever lock connection between the rim 24 and the groove 12 it is fixedly abuts against the flange 23 acting on the wall 13.

Thus, the ring 11 and the groove 12 form a circular snap-fit cantilever connection formation in the shell 2 adjacent the closing end 3, and the flange 23 and the rim 24 have a sleeve front end. A corresponding snap-fit cantilever connection forming portion is formed on the 21, and the two forming portions are formed such that the front end 21 is fixedly connected to the closing end 3 with the cantilever and the sleeve 20 is coaxially mounted in the shell. The fittings are arranged in sizes that are mutually coupled.

The shell (2) and sleeve (20) are designed to facilitate their snap-fit cantilever locking and watertight coupling and to achieve the concentric and coaxial alignment necessary to properly line up with the vial (40) in use. It is preferably formed as an injection-molded plastic part to enable the use of molds of low cost but accurate dimensions and shapes for simple assembly to precisely match and engrave pieces. For example, the shell 2 and the sleeve 20 may be sized in a 10 mL to 50 mL dosage in a constant size vial.

As shown in FIG. 1, when the open end 41 is screwed through the stop outer screw 44, the internal thread 35 of the socket 34 is fixedly fixed to the stop of the vial 40. 42). Thereby, the sharp end of the needle 32 is arranged coaxially with the stop inlet 45, penetrates the seal 46, enters the stop bore 47 and flows into the vial chamber 48. do. By gripping the flange 14, the vial 40 is provided with a sleeve outer wall 36 having a shell inner wall 10 and a longitudinal guide rib 37, which is preferably circumferentially spaced along the guide passage 38. Is pressurized between

The rib 37 allows the circumferential arc portion between the ribs 37 to form a recessed space in the outer wall 36 while maintaining the material and lightening the structure without damaging the rigid structural form of the sleeve 20. At the same time, the size of the annular clearance of the guide passage 38 is selectively determined between the outer radius of the sleeve 37 and the inner radius of the shell wall 10 to match the radial dimension of the vial 40. The rib 37 prevents rocking between the shell 2, the sleeve 20 and the vial 40 and prevents misalignment between the needle 32 and the stop inlet 45.

A 10 mL sized vial 40 filled with a 10 mL size device 1 and only half of the agent P is used, for example by moving the stop 42 half to the open end 41, where appropriate The device 1 can be used for smaller doses, thus eliminating the need for a 5 mL size device 1 (and closure cap) and a 5 mL size vial 40 and stop 42. Similar to using a cap to block the open end 4, the nozzle 7 and the tube 5a, the tip 41 of the half-filled vial 40 is also closed by the cap.

A half-filled vial is inserted into the stop 42, which is screwed into the guide passage 38 and the socket 34, so that the needle 32 enters the stop inlet 45 and penetrates the seal 46. When the vial 40 is pushed further into the device 1, the stop 42 is fixedly connected to the socket 34, for example when connected to an independent dispensing device, and the medicine P is needled. It is sent from the filled second half of the vial 40 to the tube via 32, passage 27 and bore 6.

4 to 6 show another embodiment in which similar parts of FIGS. 1 to 3 are denoted by a prime symbol ('). The devices 1 of FIGS. 1 to 3 are used for large doses, while the devices 1 ′ of FIGS. 4 to 6 are used for small doses of, for example, 0.5 mL to 3 mL, and of similar standard, prescribed Needle 32 ', a bevel metal needle (BD IV 196A x 1½'), and injection molded plastic parts such as shell 2 'and sleeve 20'.

The device 1 'is the same as that of the device 1 but smaller and the same for use with a similar vial 40' of parts 41'-48 'that is smaller. A shell 2 'of 3' to 15 'and a sleeve 20' of parts 21 'to 24', 29 'to 30', and 32 'to 38'. However, the needle mounting portion of the sleeve 20 'is a device 1 when the device 1' is too small to be too difficult and expensive to provide the structure of the device 1 to the device 1 '. Modifications are made for similar parts of.

The device 1 'is equipped with a needle mount with an enlarged central circular hollow recess and a circular shoulder, which is coaxial with the rim 24' and accommodates the color flange 33 'and the flange 33'. It is sized to engage a shoulder positioned so as to be mounted directly to the recessed portion and the sheet 56 'surrounding it. The recessed portion is a large diameter central circular throated portion facing forward at the sleeve front end 21 ′ which is constrained outwardly by a front thin wall cylindrical neck 250 extending rearward from the sleeve flange 23 ′ ( 260 and a rearward facing small diameter central cylindrical shank recess 280 confined to the outside by a thin wall cylindrical shank 270 extending rearward from the neck 250 and separated by a shoulder 310; have.

As shown in FIG. 4, the shell bore 6 ′ and the needle 32 ′, similar to the recess 26, the passage 27, the extension 28 and the thread 31 of the device 1, are shown in FIG. 4. ) Are arranged in size to position the color flange 33 'on the sheet 56' and axially rearward of the foremost limit of the neck 250 in a watertight position relative to the sheet 56 '. .

As shown in FIGS. 5-6, the neck 250, similar to the space 25 of the device 1, has a ring 11 ′ for snap-in engagement in the groove 12 ′. It is sized to support the local compression displacement of the rim 24 '.

Neck 250, size of shoulder 310 and shank, size of recesses 260 and 280 for color flange 33 'and size of rim 24' for groove 12 'and sheet 56'. By accurately determining, when the rim 24 'is secured to the sheet 5b', the color flange 33 'is rigidly and automatically seated against the sheet 5b' and then in one axial direction with respect to it. It is held by a shoulder 310 and shank 270 connected to the neck 250 via an acting rim 24 'and a sheet 5b' acting in the opposite axial direction thereto.

In both devices 1 and 1 ', when the vial is screwed into the socket, the pushing and rotating movement of the vial prevents possible rotation of the sleeve relative to the shell, which presses the rim against the groove and It exerts a frictional force that forces the flange against the radial wall.

In the device 1, this force also forces the recess 26 against the sheet 5b and similarly prevents the extension 28 in order to similarly prevent possible rotation of the sleeve 20 and the needle 32. The needle 32 is pressed against it. In the device 1 ', this force presses the sink 270 and the shoulder 310 against the color flange 33', the color flange against the sheet 5b ', and at the same time a thin wall neck 250 Axial compression). The neck 250 is thick enough to withstand the axial tension between the rim 24 'and the shoulder 310 in retaining the color flange 33' on the sheet 5b '.

Thus, the structure of the device 1, 1 ′ consists of two separate pieces that are manufactured at low cost and are not interconnected, snapped or otherwise integrally interconnected by a snap fit, and are standard commercially available. Binary units that combine useful types of needles can be manually assembled at low cost by unskilled personnel.

The two separate pieces are formed and arranged in exact size and shape with each other to maintain snap-fit cantilever interconnections, which parts must be precisely centered, in particular any standard needle mounted with a cantilever In the event of an emergency, unaligned or otherwise, the sleeve socket must be centered and the filling, delivery and / or dispensing of the drug via a separate standard filling and / or dispensing device must be performed quickly and safely for the patient and the device user. This centering is important for drilling the center of the vial stop without accident.

The part is sized so that the sharp end of the needle lies slightly inward of the sleeve open end, coaxial with the socket, in order to sufficiently protect the needle from unexpected contact with humans. Due to the precise watertight fit of the device 1 and the associated internal parts of the device 1 ′, through the passage 27 and the bore 6 in the device 1, or in the bore 6 in the device 1 ′. The flow passage from the vial through the bay to the needle is fully protected and there is no unused space.

Of course, the circular connection formed by the flanges and the rim on the sleeve front end 21 or 21 'is circumferentially like a gear to form a continuous circular formation of an uninterrupted circular profile, or a suspended circular profile such as a tooth. It can be a discrete circular formation notched in, to achieve the above snap-fit interconnection.

Since the rings and grooves are formed in the shell and the flanges and rims are formed in the shell as integral parts in the apparatus 1, .1 ', they are not misaligned with the needle and the stop bore, and the stop is easy inside the socket. Accurately centered and axially positioned with tolerances controlled by the injection molding process, the needle mounted to be fast and securely screwed can be coaxially aligned with the stop inlet of the vial more accurately.

On the other hand, once off the center, when the vial stop is rotated into the socket, the needle will be buried inside the thick sidewall of the stop and not in fluid contact with the vial contents, thereby making the unit inoperable and attempting an emergency scan. This is the result that should be avoided. In this case, applying additional force to achieve a flow linkage increases the risk of breaking the vial and injuring the user.

Referring to a further alternative embodiment illustrated in FIG. 7 in which like parts of FIGS. 1 to 3 are denoted by double prime marks (), a syringe mixer and syringe device 50 are shown, which are longitudinally cylindrical. Relevant conventional pharmaceutical powder or liquid containing vials and adapters (51) in the form of hollow outer shells (2) and cylindrical inner sleeves (20), adapters (51), and plunger vials (40 '') for syringes (1). A two-way syringe device (1) comprising a filling vial (52) containing an associated chemical liquid.

The shell 2 has a front closed end 3 and a rear open end 4, and extends longitudinally from the front end 3 to the rear end 4, for example to form a central protected fluid passage. have.

The shell 2 flows through these passages in a protected watertight manner and a nozzle groove 8 comprising, for example, a central tapered tube 54 which forms the inner end of the protected fluid passage as described below. To this end there is provided a connection nozzle 7 with a connection formation, for example a tour lock tab 9, arranged to form a male connection formation for releasably interconnection with a coupling on the adapter 51.

The cylindrical inner wall 10 of the shell 2 forms an interior to receive the guide vial 40 coaxially through the end 4 for relative longitudinal and rotational movement, the open end 41 of the vial It is closed by a movable cylindrical spike-penetrating stop 42 with a ring 43 which seals the contents of the powdered medicine P, for example.

The inner wall 10 is axially between the radially inwardly constricted ring 11 near the closed end 3 and the radial front wall 13 forming the ring 11 and the closed end 3. It has a circular locking groove 12 directed radially inward. The ring 11 is formed of a hollow, e.g., cone shaped inclined portion 11a at an angle of about 30 degrees, a hollow cylindrical central span 11b, and a conical lock inclined portion 11c of an opposing hollow, eg at an angle of about 45 degrees. do.

The wall 10, the ring 11, the groove 12, and the sheet 5b are circular sections, concentric and coaxial, and the bores 6 extend along the central axis of the shell 2.

The sleeve 20 has a front cantilever mounting end 21 and a rear free end 22. The front end 21 is sized to interact with the ring 11 and the groove 12 to connect the front end 21 of the sleeve 20 in a cantilever manner to the front end 3 of the shell 2. It is arranged and has a radially outward circular flange 23 which forms a circumferential end in the circular compression rim 24. The front end 21 also has a forwardly tapered concave in the forward direction communicating with a central circular, e.g., tapered extension 28, which is directed backward through the circular depression 25 and the central inner passage 27. Equipped with 26.

The sleeve 20 extends toward the front closing end 3 formed as an inner recess of an annular or hollow cylindrical shape for receiving and guiding the plunger vial 40 coaxially to be relatively longitudinally and rotationally movable. A guide passage 38 is provided. The sleeve 20 is formed therein and forms an outer end of the protected fluid passage with a connecting socket 34 having an internal thread 35 and protrudes coaxially into the socket 34, for example coaxially, The socket 34 is equipped with, for example, a relatively short tubular spike 55 in the center that ends sufficiently inwards from the rear open end 4 to protect the spike 55 from unexpected contact with the person. A lateral flange 14 may be formed on the rear open end 4 as a user grip.

The plunger vial 40 associated with the syringe includes a chamber 56, a closed back end 57, and a movable internal cylindrical stop filled with a predetermined dose of liquid or solid P, such as powdered medicament. It can be of the conventional type of, for example, a cylindrical member with an open front end 41 sealed by 42. The stop 42 is screwed through an inner central bore 58 that includes an external thread 44 and a penetrating seal 59 near the foremost portion of the tip.

The exterior of the plunger vial 40 may have grid lines indicating dose or other indications.

The plunger vial 40 and the guide passage 38 have a cylindrical plunger vial 40 open end 41 open behind the syringe for rotation and longitudinal reciprocation of the plunger vial 40 on the syringe 2. It is coaxially arranged in size for mutual engagement so as to be slidably coaxially inserted into the corresponding recess of the guide passage 38 at the end 4. In addition, the stop 42 and the socket 34 are such that when the plunger vial 40 is rotated with respect to the syringe 2, the spike 27 passes through the seal 59 coaxially, e. Coaxially sized for mutual engagement such that the external threads 44 on top of the stop 42 are sufficiently screwed onto the internal threads 35 of the socket 34 to flow-connect the 56 in a protected watertight state. Arranged (see Figure 8).

Since the plunger vial 40 is initially filled with a relatively small amount of drug P, the stop 42 is located at a concave point away from the open end 41 so that the plunger vial 42 is spiked. 55 can be inserted into the guide passage 38 without penetrating the seal 59 (FIG. 7).

Similarly, the adapter 51 has an inner end 62 and an outer end 63 and a central protected fluid passage 64 extending longitudinally from the inner end 62 to the outer end 63, for example. Equipped.

The adapter inner end 62 is formed of the recess 8 of the shell 2 and the corresponding connection nozzle 66 with a central tapered recess or inlet 67 forming the inner end of the passage 64, for example. A male connection forming portion formed by the luer lock tab 9 and the tube 54 and a connection forming portion such as a luo lock tab 67 arranged to form a female connection forming portion that can be releasably interconnected with each other, for example, The flow passages 27 and 64 are flow-tightly connected in a protected watertight manner with no unused space (Fig. 8).

The adapter outer end 63 has its own passageway 68 which extends towards the inner end 62, for example formed as a coaxial cylindrical outer surface, so that the filling vial (e.g. 52) Accept and guide. The outer end 63 is formed therein and forms an outer boundary of its own connection socket 69 and passageway 64 provided with an internal thread 70 and protrudes coaxially into the socket 69 and the socket 69. In order to protect the spike 71 from unexpected human contact, it has a tubular spike 71 which terminates sufficiently inward of the outer end 63.

The filling vial 52 associated with the adapter has a main diameter body portion that engages the chamber 72, the closed back end 73 and the inner surface of the chamber 72 filled with a predetermined dose of the liquid medicament L. The outer seal ring 76 on the top and a coaxial outer thread 77 on a reduced diameter cylindrical tip portion spaced inwardly from the inner surface of the chamber 72, also the foremost portion of the tip (shown in phantom in FIG. 7). Of a cylindrical member with an open front end 74 sealed by a movable inner cylindrical stop 75 with a central inner bore 78, for example, with a permeable seal 79 at its periphery. It may be of a conventional type.

The filling vial 62 and the guide passage 68 have an open end 74 of the cylindrical filling vial 52 outside the adapter for rotation and longitudinal reciprocation of the filling vial 52 on the adapter 51. It is coaxially arranged in size for mutual engagement so as to be slidably coaxially inserted onto the corresponding surface forming guide passageway 68 at the end 63. In addition, the stop 75 and the socket 69 have a passage 64 through which the spike 71 penetrates the seal 78 coaxially, for example, when the charge vial 52 is rotated with respect to the adapter 51. ) So that the outer thread 77 at the top of the stop 75 is sufficiently screwed onto the inner thread 70 of the socket 69 to flow-connect the chamber 73 to the protected watertight state. Coaxially arranged in size for (Fig. 8).

Similarly, the stop 75 is fixedly connected to the thread 70 of the socket 69 by its thread 77, but is movable in the chamber 72, so that The stop 75 is moved in the longitudinal direction with respect to the open end 74 by the reciprocating motion, and since the filling vial 52 initially contains a relatively large amount of the chemical liquid L, the stop is initially Positioned near the open end, the spike 69 can penetrate the seal 79 of the stop 75 as soon as the filling vial 52 is inserted onto the guide passage 68 (FIG. 7). ).

Preferably, in each of the syringe 1 and the adapter 51, each socket 34, 69 forms a cylindrical recess and each short spike 55, 71 is centrally arranged coaxially with the respective recess. The axial hollow hollow cylindrical section. Each spike 55,71 is also cantilevered and has a sharp free end and a base end integral with the adjacent portion of the corresponding end of the syringe 50 and the adapter 51.

Thus, the corresponding nozzle 66 of the adapter 51 is connected to the nozzle 7, the plunger vial 40 is mounted on the guide passage 38 of the syringe 2, and the filling vial 52 When mounted on the guide passage 68 of the adapter 51, the filling vial 69 is rotated such that the stopper is screwed into the socket 69 such that the spike 71 penetrates the seal 78. The plunger vial 40 is then rotated such that the stop is screwed into the socket 34 so that the spike 55 penetrates the seal 59, thereby protecting the watertight plug bore 78, the passage. 64 achieves in-line flow concentration of plug bore 58 and forms a continuous, separable internal fluid conduit system with no unused space between vials.

Then, the filling vial 52 is pushed toward the adapter 51 so that the liquid L is discharged from the chamber 72 through the plug bores 78, the passages 64 and 27, and the plug bores 58. Thereby allowing the plunger vial 20 to withdraw from the syringe 1 when the liquid L is filled in the chamber 57 and mixed with the solid or liquid P already present therein. (Figure 8). This adhering component may be shaken manually if necessary to ensure complete mixing of the agents (P, L) in the plunger vial 40, but the basic procedure for mixing the agents (P, L) is One-way, one-step delivery of liquid L from vial 52 to vial 40 via adapter 51 and syringe 1 without L being passed back to vial 52 at all. Is made by.

The adapter 51 and the vial 52 can then be separated from the syringe 4 and the vial 40 and have a beveled inlet and a luerlock tab, ie a number on the syringe nozzle 7. An independent standard disassembly device for forming a female connection forming part corresponding to the connecting part can be immediately attached directly to the nozzle 7 without disturbing deformation, and the plunger vial 40 mixed on the outer end 4. A syringe 1 with a desired predetermined dose of drug P, L) and an attachment dispensing device on the inner end 3 to be used immediately dispense a mixed drug.

A separate standard dispensing device is for example a three-way stop cock or a latex release eye of an intravenous injection unit. Non-injection of, for example, a drug mixture with a protected needle inserted into the V (IV) inlet or the like, or a joining portion engaged with the forming portion of the syringe nozzle 6, such as the combined luerlock linkage described above. May be another dispensing device.

This luer lock formation allows for easy and rapid connection and release of the corresponding nozzle 34 of the adapter 51 onto the syringe nozzle 6 and formation of a corresponding connection of the dispensing device, which can be of standard size. This luerlock connection forming part is quickly and easily connected or disconnected, for example by turning it clockwise to connect it or counterclockwise to release it.

Commercially useful drug mixing and delivery syringes also use syringe elements with sharp, sharp needles that are permanently attached and exposed together with other components, so that when the gentle delivery and re-delivery steps are performed for mixing, the exposed needle may In order to bend back and forth until it is bent, the user must take additional time to be unfavorable, and be careful, and the user may be at risk of having his or her fingers stuck in the sharp part of the needle before the independent dispenser is attached to dispense the mixed medication. have.

On the other hand, the spikes 55, 71 must be long enough to penetrate the vial seals 69, 79 to provide communication between the vial chamber 72 and the vial chamber 57. Thus, the spike preferably enters the socket 34,39 only a considerable distance from the inlet, and then from the outer end to protect this relatively short spike 55,71 from contact with an unintended person. While in, it can easily and quickly penetrate the seals 59, 79 by simply rotating the vials 40, 52 relative to the syringe 2 and the adapter 63.

All parts of the syringe 1 and the adapter 51 each comprise a nozzle 7 and their luerlock connection formation, and their spikes 55 and 71 are suitable rigid plastics such as polycarbonate, for example by injection molding techniques. Each spike is recessed relative to the socket opening to form the one piece member syringe 1 and the adapter 51 and adjacent the inner side of the syringe and the adapter forming an injection molded inner protective passage such as a short cantilevered tubular structure. It is integrally interconnected with the socket part.

However, the structural part defining the nozzles 7, 66 consists of an injection molded part integrally with each of the syringe shell 1 and the rest of the adapter 51, while optionally each of these nozzles 6, 34. The structural part defining) is supplied as separate parts, for example in standard standard sizes, and mounted and connected on the rest of each syringe 1 and adapter 51, for example, by sonic welding technology. Depending on the amount of drug formulation to be mixed and administered, it may be any suitable size in a variety of sizes, but is formed to accommodate nozzles 7, 34, which are conventional standard sizes.

The specification and drawings are to be regarded in an illustrative rather than a restrictive sense, and various modifications and changes may be made without departing from the spirit and scope of the invention as defined by the claims.

Claims (26)

In the binary syringe device (1), the syringe device comprises a long hollow outer shell (2) and a cylindrical cylindrical inner sleeve (20), the outer shell (2) having a front closing end (3) and a rear An open end 4, a cylindrical cylindrical inner wall forming a chamber inside the shell, a hub coaxial with the inner wall extending through the closed end from the chamber to a forward point outside the shell, extending through the hub A bore 6, a coaxial sheet 5b enclosing the bore in the chamber, a tube 5a formed by a hub end outside the shell, and a snap-fit lock assembly formed on the end of the inner wall near the closing end. A first portion (11, 12), the inner sleeve (20) has a front end (21), a coaxially mounted tubular spike (55), and a rear end (22). Cantilever the inner sleeve to the chamber A second portion 24 of the snap-fit lock assembly is formed on the inner sleeve front end for mounting in a burr manner, the front end being the seat when the sleeve is operably mounted to the shell. And a sealing means for sealing engagement with said spike, said spike being rearward and having a sharp end ending sufficiently inward of the rear open end of the outer shell to prevent the spike from inadvertently contacting a human being. 27) extends through the spike and the inner shell, wherein the radial outer diameter of the sleeve is smaller than the diameter of the inner wall so that the sleeve is between the inner wall and the sleeve when the sleeve is operably mounted to the shell. An annular space is formed, the sleeve having a connecting socket at the rear end and the spar A large protrusion protrudes into the socket and the syringe device is adapted to receive a cylindrical drug vial 40 at the open end of the shell, the vial having a wall thickness shorter than the radial distance to the sleeve. It has a hollow cylindrical wall (41), the vial is slidable with respect to the shell and guided to move by interaction with the wall and the sleeve or any one of the vias. Has an open end closed by a possible stop 42, the stop having a protrusion shaped to be retained in and connected to the socket, the stop sliding axially in the vial. And the spikes may cause the spike flow passage and bore when the vial is operably connected to the syringe device. To 2 wonsik syringe apparatus that sharp tip to provide a water-tight flow between said vial and said tube characterized in that it is configured to pass through parts of the still. 2. The snap fit lock assembly of claim 1 wherein the first portion of the snap fit lock assembly is formed by a radially inward shrinkage ring (11) formed near the front end of the inner wall, and the second portion of the snap fit lock assembly is the sleeve Formed by a radially outward locking flange 23 on the front end of the flange, the flange is snap-locked with the shrinkage ring when the sleeve is operably inserted into the shell so that the sleeve cantilevered to the shell. A two-way syringe device, characterized in that arranged for mounting. 3. The coaxial needle mount according to claim 1 or 2, wherein the spike is in the form of an elongated needle 32 having a front collar flange 33, wherein the sleeve mounts the needle to the sleeve in a watertight manner. Two-way syringe device comprising a. 3. The shell of claim 2, wherein the shell has a substantially radial front wall that defines a closed end thereof, and the sleeve flange is sized to abut against the front wall when the flange is snap-fitted with the ring. Two-way syringe device, characterized in that arranged in. 3. The needle mounting portion of claim 2, wherein the needle mounting portion includes a central circular recess facing forward at the front end of the sleeve, a central circular extension facing backward, and a sand flow passage extending from the recess through the extension portion. And a flange is arranged to be coaxially mounted to the extension, and the recess is arranged to receive the sheet coaxially. 6. A two-way syringe device according to claim 5, wherein said needle mount has a connecting means adjacent said extension and said collar flange has corresponding connecting means for connecting said needle to the sleeve at the extension. 4. The method of claim 3, wherein the sleeve is radially formed between the sleeve flange and the recess to form a concentric compression compensation space to help local compression displacement of the flange for snap fit locking in the groove through the ring. And an annular depression (25) extending from the front end of the sleeve toward the extension portion. 4. The needle mounting portion according to claim 3, wherein the needle mounting portion includes a central circular hollow recess portion 26 having a circular shoulder portion, wherein the recess portion, the shoulder portion and the flange are coaxial, and the recess portion and the shoulder portion are The collar flange is sized to receive the collar flange and engage with the concave portion surrounding the collar flange, and the shoulder portion is positioned axially so that the flange is mounted directly on the sheet. 2-way syringe device. 9. The large diameter central wood neck portion of claim 8, wherein the concave portion is forward facing at the sleeve front end constrained outward by an anterior thin wall neck portion 250 extending rearwardly from the sleeve flange. 260, and a small diameter central circular shank concave portion 280 facing outwardly limited by the thick wall shank portion 270 extending rearward from the neck portion and separated by the shoulder portion, wherein The shoulder portion is arranged to axially position the collar flange to the rear of the foremost limit of the neck portion, wherein the neck portion is sized to assist the compression displacement of the flange to snap fit lock in the groove through the ring. Two-way syringe device characterized in that. 2. The shell of claim 1 wherein the shell confines the tube outwardly at its closed end and is connected to an independent filling, mixing or dispensing device in use to provide watertight flow between the vial and the independent device through the needle and tube. Two-way syringe device, characterized in that it has an external nozzle (7) disposed. 11. A two-way syringe device according to claim 10, wherein the nozzle has a luer lock connection (9) for engaging with a mating luer lock connection such that it is releasably interconnected on the independent device. 2. A bidirectional syringe device according to claim 1, characterized in that the socket (34) has an inner threading means (35) for engaging with a mating outer threading means (44) on a stop of a corresponding vial to be connected thereto. 2. A two-way syringe device according to claim 1, wherein said shell and sleeve are formed from plastic injection molded parts for snap-fit cantilevered connections. In the binary syringe device (1), the syringe device comprises a longitudinal hollow outer shell (2) and a cylindrical inner sleeve (20), the outer shell (2) having a front closure end (3), a rear opening End 4, cylindrical inner wall, shell which forms a suitable interior for receiving a cylindrical drug vial 42 closed by the penetrating stop 42 in use coaxially through the open end and guiding relative movement thereto A central hub 5 having a bore 6 extending therethrough from the outer hub tube 5a to the inner hub circular sheet 5b and extending from the tube to the sheet, and a shell adjacent the closing end An inner circular snap-fit cantilevered connection forming portion (11, 12), the inner wall, the connection-forming portion and the sheet are coaxial, and the inner sleeve (20) is a relative circular snap-fit cantilevered connection forming portion (24). With Rear free end 22 having a front cantilever mounting end 21, a central needle mounting 28 and a cylindrical connecting socket 34 suitable for fixedly connecting the stop, and a front circular collar flange 33 And a hollow needle 32 having a rear sharp end, wherein the sleeve, the mating connection forming portion, the needle fitting portion, and the socket are coaxial, and the sleeve has a sufficient radius of its inner wall such that the vial is inserted therebetween. Sized in the shell at an angular foot, wherein the linkage forming portion and the mating linkage forming portion snap-fit to coaxially mount the sleeve in the shell such that the sleeve front end is cantileveredly fixed to the shell closure end. The needle mounting portion is arranged to mount the needle so as to be watertightly coaxially with the bore and the sleeve, A collar flange is in flow communication with the bore and is disposed coaxially in the socket such that a sharp end of the needle passes through the stop to provide protected watertight induction between the vial and the tube through the needle and the bore. 2-way syringe device. In the syringe mixer and binary syringe device comprising the binary syringe and adapter 51 according to claim 1, the syringe and the adapter extend longitudinally from the front end to the rear open end and from the front end to the rear end, respectively. With a protected fluid passage therein, the two-way syringe includes an external nozzle at its front closure end, and the adapter includes a mating connection nozzle 66 defining an interior boundary of the passage at its front closure end. And the outer nozzle and the mating connection nozzle are arranged to releasably interconnect the syringe and the adapter to flow-connect the passage in a protected watertight condition, the adapter extending from the rear open end toward the front closed end and Receives and relative to a cylindrical medicine vial having an upper end closed by a penetrable stop in use It has a guide passage suitable for guiding the copper, and is connected from the rear open end to the connection socket 69 of the rear open end and the socket to protrude into the socket and to prevent inadvertent contact with human being. And a tubular spike (71) which terminates sufficiently inward and flows through the stop to flow-tightly communicate the vial with the passageway during use. 16. The apparatus of claim 15, wherein the nozzle and the mating nozzle have mating luerlock connections for releasably interconnecting the syringe and the adapter. 17. The apparatus of claim 16, wherein each socket defines an axial cylindrical recess and each spike defines an axial hollow cylindrical tubular portion disposed coaxially with the respective recess. 18. The device of claim 17, wherein each spike has a cantilevered free end and a base integrated with the proximal end of the corresponding end of the syringe and adapter through which each passage extends. 19. The bidirectional syringe device of claim 18, wherein each socket has an internal threaded connection adapted to engage a mating external threaded connection on a stop of a corresponding vial to be connected thereto when in use. 20. The device of claim 19, wherein the shell and sleeve of the binary syringe device and adapter are formed from plastic injection molded parts. In the syringe mixer and binary syringe device comprising the binary syringe and adapter 51 according to claim 14, the syringe and the adapter extend longitudinally from the front end to the rear open end and from the front end to the rear end, respectively. With a protected fluid passage therein, the two-way syringe includes an external nozzle at its front closure end, and the adapter includes a mating connection nozzle 66 defining an interior boundary of the passage at its front closure end. And the outer nozzle and the mating connection nozzle are arranged to releasably interconnect the syringe and the adapter to flow-connect the passage in a protected watertight condition, the adapter extending from the rear open end toward the front closed end and Receives and relative to a cylindrical medicine vial having an upper end closed by a penetrable stop in use It has a guide passage suitable for guiding movement, and from the rear open end to prevent the inadvertent contact with the socket and a connection socket 69 of the rear open end suitable for fixedly connecting the stop. And a tubular spike (71) which terminates sufficiently inward and flows through the stop to flow-tightly communicate the vial with the passageway during use. 22. The apparatus of claim 21, wherein the nozzle and the mating nozzle have mating luerlock connections for releasably interconnecting the syringe and the adapter. 23. The apparatus of claim 22, wherein each socket defines an axial cylindrical recess and each spike defines an axial hollow cylindrical tubular portion disposed coaxially with the respective recess. 24. The device of claim 23, wherein each spike has a cantilevered free end and a base integrated with the proximal end of the corresponding end of the syringe and adapter through which each passage extends. 25. The bidirectional syringe device of claim 24, wherein each socket has an internal threaded connection adapted to engage a mating external threaded connection in a stationary injury of a corresponding vial to be connected thereto when in use. 27. The device of claim 25, wherein the shell and sleeve of the binary syringe device and the adapter are formed from a plastic injection molded part.

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