JPWO2023105793A5 - - Google Patents

Claims (7)

The components include an ion source that ionizes sample components, a mass separator that separates ions according to their mass-to-charge ratio, an ion detector that detects the separated ions, and a combination of the ion source and the mass separator. A mass spectrometer including one or more ion transport optical systems disposed in between, and a measurement unit having an auto-tuning function for optimizing parameter values in multiple of the components. And,
Prior to execution of auto-tuning, the measurement section is controlled to perform mass spectrometry on the standard sample under predetermined parameter values, and from the mass spectrometry results, one of sensitivity, mass resolution, and mass accuracy is determined. a system check execution unit that acquires information corresponding to a plurality of check items including at least one;
It is determined whether the information corresponding to the plurality of check items obtained by the system check execution unit each satisfies a predetermined pass/fail condition, and if it is determined that the information corresponds to the plurality of check items does not pass, then the information corresponding to the check items that have failed is determined. a check result determination unit that identifies components that require auto-tuning;
The measurement unit is controlled to perform mass spectrometry on the standard sample while changing the value of the parameter of the component identified by the check result determination unit as requiring auto- tuning. and an auto-tuning execution unit that adjusts the value of the parameter so that the mass spectrometry result satisfies predetermined adjustment conditions;
A mass spectrometer equipped with. The mass spectrometer according to claim 1 , wherein the check items include sensitivity, and the auto-tuning execution unit adjusts the voltage applied to at least one of the ion transport optical systems when the sensitivity fails. Device. The mass spectrometer according to claim 1 , wherein the check items include sensitivity, and the auto-tuning execution unit adjusts the gain by adjusting the voltage applied to the ion detector when the sensitivity is rejected. Device. The mass separator is a quadrupole mass filter, the check items include a mass resolution indicated by the half-width of the mass peak, and the auto-tuning execution unit controls the quadrupole mass filter when the half-width is not acceptable. The mass spectrometer according to claim 1 , wherein the ratio of DC voltage and RF voltage applied to the mass filter is adjusted. The mass separator is a quadrupole mass filter, the check items include mass accuracy indicated by mass axis deviation, and the auto-tuning execution unit controls the quadrupole mass filter when the mass axis deviation fails. The mass spectrometer according to claim 1 , wherein the magnitude of the RF voltage applied to the mass filter is adjusted. a recording unit that records mass spectrometry results and parameter settings before and after performing the autotuning;
an output unit that displays or prints out the information recorded by the recording unit in response to a user's operation;
The mass spectrometer according to claim 1, further comprising: 2. The mass spectrometer according to claim 1 , further comprising: an information receiving unit that receives input from a user of a determination threshold that is a pass/fail condition for the plurality of check items.