JPWO2022174144A5 - - Google Patents
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- Publication number
- JPWO2022174144A5 JPWO2022174144A5 JP2023548848A JP2023548848A JPWO2022174144A5 JP WO2022174144 A5 JPWO2022174144 A5 JP WO2022174144A5 JP 2023548848 A JP2023548848 A JP 2023548848A JP 2023548848 A JP2023548848 A JP 2023548848A JP WO2022174144 A5 JPWO2022174144 A5 JP WO2022174144A5
- Authority
- JP
- Japan
- Prior art keywords
- dna
- composition
- domain
- cell
- modifying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020004414 DNA Proteins 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 19
- 238000000034 method Methods 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 102000004190 Enzymes Human genes 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 102000053602 DNA Human genes 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 108020005004 Guide RNA Proteins 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 230000003197 catalytic effect Effects 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 230000000903 blocking effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 102220479043 BEN domain-containing protein 3_K56A_mutation Human genes 0.000 claims 1
- 230000008836 DNA modification Effects 0.000 claims 1
- 230000004543 DNA replication Effects 0.000 claims 1
- 102220587937 Deoxyhypusine hydroxylase_M86L_mutation Human genes 0.000 claims 1
- 102000007260 Deoxyribonuclease I Human genes 0.000 claims 1
- 108010008532 Deoxyribonuclease I Proteins 0.000 claims 1
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 1
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 1
- 102220465587 Insulin-like growth factor II_R92A_mutation Human genes 0.000 claims 1
- 102220511417 Proteasome subunit beta type-10_G49D_mutation Human genes 0.000 claims 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical class N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- 230000003833 cell viability Effects 0.000 claims 1
- 230000007541 cellular toxicity Effects 0.000 claims 1
- 230000008711 chromosomal rearrangement Effects 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 238000010441 gene drive Methods 0.000 claims 1
- 230000037442 genomic alteration Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163149419P | 2021-02-15 | 2021-02-15 | |
| US63/149,419 | 2021-02-15 | ||
| PCT/US2022/016313 WO2022174144A1 (en) | 2021-02-15 | 2022-02-14 | Site-specific genome modification technology |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024506375A JP2024506375A (ja) | 2024-02-13 |
| JP2024506375A5 JP2024506375A5 (https=) | 2025-02-20 |
| JPWO2022174144A5 true JPWO2022174144A5 (https=) | 2025-02-20 |
Family
ID=82837338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023548848A Pending JP2024506375A (ja) | 2021-02-15 | 2022-02-14 | 部位特異的ゲノム修飾技術 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240229012A9 (https=) |
| EP (1) | EP4291664A4 (https=) |
| JP (1) | JP2024506375A (https=) |
| CN (1) | CN117222741A (https=) |
| WO (1) | WO2022174144A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118620868A (zh) * | 2023-03-07 | 2024-09-10 | 上海科技大学 | IscBn-ωRNA编辑系统及其应用 |
| WO2024192291A1 (en) | 2023-03-15 | 2024-09-19 | Renagade Therapeutics Management Inc. | Delivery of gene editing systems and methods of use thereof |
| AU2024335327A1 (en) | 2023-09-01 | 2026-03-26 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| WO2025064917A1 (en) * | 2023-09-21 | 2025-03-27 | North Carolina State University | Programmable base editing |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| CN121495966B (zh) * | 2026-01-13 | 2026-04-17 | 山东大学 | 一种高效无痕编辑黏细菌基因组的方法及应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015021426A1 (en) | 2013-08-09 | 2015-02-12 | Sage Labs, Inc. | A crispr/cas system-based novel fusion protein and its application in genome editing |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| WO2017040511A1 (en) * | 2015-08-31 | 2017-03-09 | Agilent Technologies, Inc. | Compounds and methods for crispr/cas-based genome editing by homologous recombination |
| WO2018152197A1 (en) * | 2017-02-15 | 2018-08-23 | Massachusetts Institute Of Technology | Dna writers, molecular recorders and uses thereof |
| WO2020123512A1 (en) * | 2018-12-10 | 2020-06-18 | The Board Of Trustees Of The Leland Stanford Junior University | Anti-crispr-mediated control of genome editing and synthetic circuits in eukaryotic cells |
-
2022
- 2022-02-14 EP EP22753488.0A patent/EP4291664A4/en active Pending
- 2022-02-14 CN CN202280027473.3A patent/CN117222741A/zh active Pending
- 2022-02-14 WO PCT/US2022/016313 patent/WO2022174144A1/en not_active Ceased
- 2022-02-14 JP JP2023548848A patent/JP2024506375A/ja active Pending
- 2022-02-14 US US18/546,378 patent/US20240229012A9/en active Pending
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