JPWO2022102731A1 - - Google Patents
Info
- Publication number
- JPWO2022102731A1 JPWO2022102731A1 JP2022562190A JP2022562190A JPWO2022102731A1 JP WO2022102731 A1 JPWO2022102731 A1 JP WO2022102731A1 JP 2022562190 A JP2022562190 A JP 2022562190A JP 2022562190 A JP2022562190 A JP 2022562190A JP WO2022102731 A1 JPWO2022102731 A1 JP WO2022102731A1
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020189152 | 2020-11-13 | ||
| JP2020211006 | 2020-12-21 | ||
| JP2021006828 | 2021-01-20 | ||
| PCT/JP2021/041650 WO2022102731A1 (en) | 2020-11-13 | 2021-11-12 | Cancer treatment by combined use of ep4 antagonist and immune checkpoint inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPWO2022102731A1 true JPWO2022102731A1 (en) | 2022-05-19 |
Family
ID=81602339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022562190A Pending JPWO2022102731A1 (en) | 2020-11-13 | 2021-11-12 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230390303A1 (en) |
| EP (1) | EP4245301A1 (en) |
| JP (1) | JPWO2022102731A1 (en) |
| KR (1) | KR20230107228A (en) |
| TW (1) | TW202228674A (en) |
| WO (1) | WO2022102731A1 (en) |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1371416B (en) | 1999-08-24 | 2012-10-10 | 梅达里克斯公司 | Human CTLA-4 antibodies and their uses |
| KR20020076330A (en) | 2000-02-22 | 2002-10-09 | 오노 야꾸힝 고교 가부시키가이샤 | Benzoic acid derivatives, process for producing the same and drugs containing the same as the active ingredient |
| JP4929472B2 (en) | 2000-08-22 | 2012-05-09 | 小野薬品工業株式会社 | Carboxylic acid derivatives, methods for producing them, and agents containing them as active ingredients |
| AU2001278772A1 (en) | 2000-09-01 | 2002-03-22 | Ono Pharmaceutical Co. Ltd. | Benzoic acid derivatives and drugs containing the same as the active ingredient |
| HN2001000224A (en) | 2000-10-19 | 2002-06-13 | Pfizer | IMIDAZOL COMPOUNDS CONDENSED WITH ARILO OR HETEROARILO AS ANTI - INFLAMMATORY AND ANALGESIC AGENTS. |
| GB0031295D0 (en) | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Naphthalene derivatives |
| GB0031302D0 (en) | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Napthalene derivatives |
| GB0031315D0 (en) | 2000-12-21 | 2001-02-07 | Glaxo Group Ltd | Indole derivatives |
| US7491748B2 (en) | 2001-08-09 | 2009-02-17 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient |
| EP1495005A1 (en) | 2002-04-12 | 2005-01-12 | Pfizer Japan Inc. | Pyrazole compounds as anti-inflammatory and analgesic agents |
| CA2481532A1 (en) | 2002-04-12 | 2003-10-23 | Pfizer Inc. | Imidazole compounds as anti-inflammatory and analgesic agents |
| CN1662551A (en) | 2002-05-23 | 2005-08-31 | 瑟瑞技术公司 | Antagonistic peptides of prostaglandin e2 receptor subtype ep4 |
| WO2004067524A1 (en) | 2003-01-29 | 2004-08-12 | Pharmagene Laboratories Limited | Ep4 receptor antagonists |
| JP4116058B2 (en) | 2003-09-03 | 2008-07-09 | ファイザー株式会社 | Phenyl or pyridylamide compounds as prostaglandin E2 antagonists |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| WO2005061475A2 (en) | 2003-12-22 | 2005-07-07 | Astellas Pharma Inc. | Ornithine derivatives as prostaglandin e2 agonists or antagonists |
| EA200601830A1 (en) | 2004-05-04 | 2007-04-27 | Пфайзер Инк. | ORT-SUBSTITUTED ARYL OR HETEROARYL AMIDAL COMPOUNDS |
| MXPA06011555A (en) | 2004-05-04 | 2006-12-15 | Pfizer | Substituted methyl aryl or heteroaryl amide compounds. |
| EP1765379A4 (en) | 2004-06-17 | 2009-05-27 | Transform Pharmaceuticals Inc | Pharmaceutical co-crystal compositions and related methods of use |
| KR101498834B1 (en) | 2005-05-09 | 2015-03-05 | 오노 야꾸힝 고교 가부시키가이샤 | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
| ATE533766T1 (en) | 2005-05-19 | 2011-12-15 | Merck Canada Inc | QUINOLINE DERIVATIVES AS EP4 ANTAGONISTS |
| HUE026039T2 (en) | 2005-07-01 | 2016-05-30 | Squibb & Sons Llc | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) |
| US7968578B2 (en) | 2006-04-24 | 2011-06-28 | Merck Frosst Canada Ltd. | Indole amide derivatives as EP4 receptor antagonists |
| WO2007143825A1 (en) | 2006-06-12 | 2007-12-21 | Merck Frosst Canada Ltd. | Indoline amide derivatives as ep4 receptor ligands |
| AU2007283404B2 (en) | 2006-08-11 | 2013-04-18 | Merck Canada Inc. | Thiophenecarboxamide derivatives as EP4 receptor ligands |
| US8158671B2 (en) | 2007-02-26 | 2012-04-17 | Merck Canada Inc. | Indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists |
| KR20090122931A (en) | 2007-03-26 | 2009-12-01 | 아스테라스 세이야쿠 가부시키가이샤 | Ornithine derivative |
| EP2125724B1 (en) | 2007-03-26 | 2014-12-03 | Merck Canada Inc. | Naphthalene and quinoline sulfonylurea derivatives as ep4 receptor antagonists |
| DK2170959T3 (en) | 2007-06-18 | 2014-01-13 | Merck Sharp & Dohme | ANTIBODIES AGAINST HUMAN PROGRAMMED DEATH RECEPTOR PD-1 |
| US20110028463A1 (en) | 2007-07-03 | 2011-02-03 | Astellas Pharma Inc. | Amide compounds |
| BRPI0912778B1 (en) | 2008-05-14 | 2019-04-30 | Astellas Pharma Inc. | AMIDE COMPOUND, PHARMACEUTICAL COMPOSITION UNDERSTANDING SAID COMPOUND AND USE OF THE SAME FOR THE TREATMENT OF CHRONIC RENAL FAILURE OR DIABETIC NEPHROPATHY |
| WO2010019796A1 (en) | 2008-08-14 | 2010-02-18 | Chemietek, Llc | Heterocyclic amide derivatives as ep4 receptor antagonists |
| JP2012503605A (en) | 2008-09-25 | 2012-02-09 | メルク カナダ インコーポレイテッド | Beta-carboline sulfonylurea derivatives as EP4 receptor antagonists |
| HUE031408T2 (en) | 2010-09-21 | 2017-07-28 | Eisai R&D Man Co Ltd | Pharmaceutical composition |
| US9175080B2 (en) | 2010-09-29 | 2015-11-03 | Nb Health Laboratory Co., Ltd. | Antibody against human prostaglandin E2 receptor EP4 |
| US8828987B2 (en) | 2010-12-10 | 2014-09-09 | Rottapharm Biotech S.R.L. | Pyridine amide derivatives as EP4 receptor antagonists |
| WO2012103071A2 (en) | 2011-01-25 | 2012-08-02 | Eisai R&D Management Co., Ltd. | Compounds and compositions |
| ES2559513T3 (en) | 2011-07-04 | 2016-02-12 | Rottapharm Biotech S.R.L. | Cyclic amine derivatives as EP4 receptor antagonists |
| JP6124187B2 (en) | 2011-12-21 | 2017-05-10 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | Compounds acting at multiple prostaglandin receptors that confer general anti-inflammatory responses |
| AU2012358983B2 (en) | 2011-12-21 | 2017-09-14 | Allergan, Inc. | Compounds acting at multiple prostaglandin receptors giving a general anti-inflammatory response |
| CA2862263C (en) | 2011-12-27 | 2016-09-06 | Allergan, Inc. | Compounds acting at multiple prostaglandin receptors giving a general anti-inflammatory response |
| WO2013101733A1 (en) | 2011-12-27 | 2013-07-04 | Allergan, Inc. | Compounds acting at multiple prostaglandin receptors giving a general anti-inflammatory response |
| JO3296B1 (en) | 2012-06-29 | 2018-09-16 | Lilly Co Eli | Phenoxyethyl piperidine compounds |
| TWI572597B (en) | 2012-06-29 | 2017-03-01 | 美國禮來大藥廠 | Dimethyl-benzoic acid compounds |
| UA115576C2 (en) | 2012-12-06 | 2017-11-27 | Байєр Фарма Акцієнгезелльшафт | BENZIMIDASOL DERIVATIVES AS ER4 ANGAGONES |
| TW201443004A (en) | 2013-02-15 | 2014-11-16 | Lilly Co Eli | Phenoxyethoxy compounds |
| TWI636046B (en) | 2013-05-17 | 2018-09-21 | 美國禮來大藥廠 | Phenoxyethyl dihydro-1h-isoquinoline compounds |
| RU2662806C2 (en) | 2013-06-12 | 2018-07-31 | Какен Фармасьютикал Ко., Лтд. | 4-alkynyl imidazole derivative and medicine comprising same as active ingredient |
| AU2014366361B2 (en) | 2013-12-17 | 2017-04-20 | Eli Lilly And Company | Phenoxyethyl cyclic amine derivatives and their activity as EP4 receptor modulators |
| PT3083554T (en) | 2013-12-17 | 2019-06-11 | Lilly Co Eli | Dimethylbenzoic acid compounds |
| TW201607943A (en) | 2013-12-19 | 2016-03-01 | 拜耳製藥公司 | Novel benzimidazole derivatives as EP4 ligands |
| EP3099667B1 (en) | 2014-01-27 | 2017-11-01 | Allergan, Inc. | Antagonists acting at multiple prostaglandin receptors for the treatment of inflammation |
| TW201623277A (en) | 2014-03-26 | 2016-07-01 | 安斯泰來製藥股份有限公司 | Amide compound |
| WO2016021742A1 (en) | 2014-08-07 | 2016-02-11 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds as ep4 receptor antagonists |
| WO2016088903A1 (en) | 2014-12-05 | 2016-06-09 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds |
| ES2839203T3 (en) | 2015-01-09 | 2021-07-05 | Ono Pharmaceutical Co | Spiro tricyclic compound |
| WO2017014177A1 (en) * | 2015-07-17 | 2017-01-26 | 凸版印刷株式会社 | Method for evaluating health state and method for predicting long-term efficacy of anticancer agent |
| DK3325490T3 (en) | 2015-07-23 | 2020-02-03 | Takeda Pharmaceuticals Co | 1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDINE-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS |
| WO2017066633A1 (en) | 2015-10-16 | 2017-04-20 | Eisai R&D Management Co., Ltd. | Ep4 antagonists |
| CR20180323A (en) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | DERIVATIVES OF INDOL N-SUBSTITUTES AS MODULATORS OF PGE2 RECEIVERS |
| PT3482760T (en) | 2016-07-07 | 2021-12-15 | Ono Pharmaceutical Co | Combination comprising ep4 antagonist and immune checkpoint inhibitor |
| JP6269888B1 (en) * | 2016-07-07 | 2018-01-31 | 小野薬品工業株式会社 | Pharmaceutical use |
| JP7264060B2 (en) | 2017-04-18 | 2023-04-25 | テンペスト セラピューティクス，インク． | Bicyclic compounds and their use in treating cancer |
| ES2896476T3 (en) | 2017-05-18 | 2022-02-24 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives |
| AU2018268311B2 (en) | 2017-05-18 | 2022-02-10 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives as PGE2 receptor modulators |
| ES2929309T3 (en) | 2017-05-18 | 2022-11-28 | Idorsia Pharmaceuticals Ltd | Benzofuran and benzothiophene derivatives as PGE2 receptor modulators |
| EA039630B1 (en) | 2017-05-18 | 2022-02-18 | Идорсия Фармасьютиклз Лтд | N-substituted indole derivatives |
| CA3060597A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Phenyl derivatives as pge2 receptor modulators |
| US11479550B2 (en) | 2017-05-22 | 2022-10-25 | Ono Pharmaceutical Co., Ltd. | EP4 antagonist |
| CN108929281B (en) | 2017-05-27 | 2021-12-24 | 华东师范大学 | Triazole compound and synthesis method and application thereof |
| WO2019038156A1 (en) | 2017-08-22 | 2019-02-28 | Bayer Pharma Aktiengesellschaft | Use of an ep4 antagonist for the treatment of arthritis |
| CN109836434B (en) | 2017-11-27 | 2020-09-25 | 上海宇耀生物科技有限公司 | Thieno-ring compound and synthesis method and application thereof |
| US20230167504A1 (en) * | 2017-12-13 | 2023-06-01 | Hiroshima University | Method for aiding detection of pancreatic cancer |
| CN111936138B (en) | 2018-02-05 | 2024-03-08 | 深圳市原力生命科学有限公司 | Heterobicyclic compounds as EP4 receptor antagonists |
| EP3759114A4 (en) | 2018-03-02 | 2021-12-15 | Shenzhen Ionova Life Science Co., Ltd. | Heterobicyclic carboxylic acids and salts thereof |
| US10239885B1 (en) | 2018-06-18 | 2019-03-26 | Avista Pharma Solutions, Inc. | Compound 1-[2-[4-(2-ethyl-6,8-dimethylimidazo[1,2-α]pyrazin-3-yl)phenyl]ethyl]-3-(p-tolylsulfonyl)urea as a prostaglandin EP4 receptor antagonist |
| EP3820480A4 (en) | 2018-07-11 | 2022-03-09 | Arrys Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| AU2019300449A1 (en) | 2018-07-12 | 2021-03-04 | Rottapharm Biotech S.R.L. | (R)-4-(1-(1-(4-(trifluoromethyl)benzyl)pyrrolidine-2-carboxamide)cyclopropyl)-benzoic acid as EP4 receptor antagonist |
| EP3888648A4 (en) * | 2018-11-27 | 2022-08-10 | ONO Pharmaceutical Co., Ltd. | Treatment of cancer by combination of immune checkpoint inhibitor and folfirinox therapy |
| US20220064113A1 (en) | 2019-01-22 | 2022-03-03 | Keythera (Suzhou) Pharmaceuticals Co. Ltd. | Compound for inhibiting pge2/ep4 signaling transduction inhibiting, preparation method therefor, and medical uses thereof |
| CA3128024A1 (en) | 2019-01-30 | 2020-08-06 | Avista Pharma Solutions, Inc. | Chemical compounds |
| EP3693359A1 (en) | 2019-02-08 | 2020-08-12 | Medibiofarma, S.L. | New n-benzyl-2-phenoxybenzamide derivatives as prostaglandin e2 (pge2) receptors modulators |
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2021
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- 2021-11-12 JP JP2022562190A patent/JPWO2022102731A1/ja active Pending
- 2021-11-12 EP EP21891976.9A patent/EP4245301A1/en active Pending
- 2021-11-12 KR KR1020237015423A patent/KR20230107228A/en unknown
- 2021-11-12 WO PCT/JP2021/041650 patent/WO2022102731A1/en unknown
- 2021-11-12 US US18/035,608 patent/US20230390303A1/en active Pending
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|---|---|
| TW202228674A (en) | 2022-08-01 |
| US20230390303A1 (en) | 2023-12-07 |
| KR20230107228A (en) | 2023-07-14 |
| WO2022102731A1 (en) | 2022-05-19 |
| EP4245301A1 (en) | 2023-09-20 |