JPWO2022050384A5 - - Google Patents
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- JPWO2022050384A5 JPWO2022050384A5 JP2022546985A JP2022546985A JPWO2022050384A5 JP WO2022050384 A5 JPWO2022050384 A5 JP WO2022050384A5 JP 2022546985 A JP2022546985 A JP 2022546985A JP 2022546985 A JP2022546985 A JP 2022546985A JP WO2022050384 A5 JPWO2022050384 A5 JP WO2022050384A5
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- container
- assay
- liquid
- containers
- liquid supply
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- 239000007788 liquid Substances 0.000 claims description 42
- 238000003556 assay Methods 0.000 claims description 37
- 238000006243 chemical reaction Methods 0.000 claims 5
- 238000005259 measurement Methods 0.000 claims 5
- 238000001514 detection method Methods 0.000 claims 2
- 238000009434 installation Methods 0.000 claims 2
- 230000004308 accommodation Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Description
上記課題を解決するために、一態様に係るアッセイシステムは、液体を用いてアッセイを行うように構成されるアッセイ装置を含むアッセイシステムであって、前記アッセイ装置に液体を滴下可能とするように構成される液体供給装置と、前記アッセイ装置を前記液体供給装置に対して水平方向に相対的に移動可能とするように構成される移動装置と、前記液体供給装置による液体の滴下、及び前記移動装置による前記アッセイ装置の移動を制御可能とするように構成される制御装置とを備え、前記液体供給装置が、点眼容器の形態にそれぞれ構成された複数の容器を含み、各容器が、液体を収容可能とするように形成される本体部と、この本体部に収容された液体を滴下可能とするように構成される吐出口を有するノズル部とを含み、前記液体供給装置が、前記複数の容器の吐出口を下方に向けながら水平方向に互いに間隔を空けた状態で前記複数の容器を取り付け可能とするように構成される容器取付機構と、前記複数の容器の吐出口から液体を滴下させるべく前記複数の容器の本体部を押すことができるように構成される少なくとも１つの可動部材を有する容器押し機構とを含んでおり、前記容器取付機構が、前記複数の容器をそれぞれ保持する複数の容器ホルダを有し、各容器ホルダが、それに保持される前記容器の本体部に対応するように形成される受入空間を有する本体収容部と、この容器ホルダに保持される前記容器のノズル部を保持するノズル保持部とを有し、各容器ホルダの本体収容部が、それに収容される前記容器の本体部を押す前記可動部材を通過可能とするように開口する通過口を有し、前記通過口は前記本体収容部を貫通して形成されており、前記制御装置は、前記少なくとも１つの可動部材が前記複数の容器の本体部を所望の順番及びタイミングで押すために、前記容器押し機構を制御するように構成されている。 To solve the above problems, an assay system according to one aspect includes an assay device configured to perform an assay using a liquid, wherein the liquid can be dripped onto the assay device. a moving device configured to allow the assay device to move horizontally relative to the liquid supply device; dripping of liquid by the liquid supply device; a control device configured to enable control of movement of said assay device by the device, said liquid supply device comprising a plurality of containers each configured in the form of an eye dropper, each container containing a liquid. and a nozzle portion having a discharge port configured to allow the liquid contained in the body portion to drip, wherein the liquid supply device a container mounting mechanism configured to mount the plurality of containers horizontally spaced apart from each other while the discharge ports of the containers face downward; and a liquid dripping mechanism from the discharge ports of the plurality of containers. a container pushing mechanism having at least one movable member configured to be able to push the main bodies of the plurality of containers, wherein the container mounting mechanism includes a plurality of containers each holding the plurality of containers; A body accommodating portion having container holders, each container holder having a receiving space formed so as to correspond to the body portion of the container held by the container holder, and a nozzle portion of the container held by the container holder. each container holder has a nozzle holding portion for holding the container holder, and the main body accommodating portion of each container holder has a passage opening that opens so as to allow the movable member that pushes the main body portion of the container accommodated therein to pass through, and A port is formed through the body receiving portion, and the controller controls the container pushing mechanism so that the at least one movable member pushes the body portions of the plurality of containers in a desired order and timing. configured to control.
Claims (8)
前記アッセイ装置に液体を滴下可能とするように構成される液体供給装置と、
前記アッセイ装置を前記液体供給装置に対して水平方向に相対的に移動可能とするように構成される移動装置と、
前記液体供給装置による液体の滴下、及び前記移動装置による前記アッセイ装置の移動を制御可能とするように構成される制御装置と
を備え、
前記液体供給装置が、点眼容器の形態にそれぞれ構成された複数の容器を含み、
各容器が、液体を収容可能とするように形成される本体部と、この本体部に収容された液体を滴下可能とするように構成される吐出口を有するノズル部とを含み、
前記液体供給装置が、前記複数の容器の吐出口を下方に向けながら水平方向に互いに間隔を空けた状態で前記複数の容器を取り付け可能とするように構成される容器取付機構と、前記複数の容器の吐出口から液体を滴下させるべく前記複数の容器の本体部を押すことができるように構成される少なくとも１つの可動部材を有する容器押し機構とを含んでおり、
前記容器取付機構が、前記複数の容器をそれぞれ保持する複数の容器ホルダを有し、
各容器ホルダが、それに保持される前記容器の本体部に対応するように形成される受入空間を有する本体収容部と、この容器ホルダに保持される前記容器のノズル部を保持するノズル保持部とを有し、
各容器ホルダの本体収容部が、それに収容される前記容器の本体部を押す前記可動部材を通過可能とするように開口する通過口を有し、前記通過口は前記本体収容部を貫通して形成されており、
前記制御装置は、前記少なくとも１つの可動部材が前記複数の容器の本体部を所望の順番及びタイミングで押すために、前記容器押し機構を制御するように構成されている、アッセイシステム。 An assay system comprising an assay device configured to perform an assay with a liquid,
a liquid supply device configured to allow a liquid to be dripped onto the assay device;
a movement device configured to allow the assay device to move horizontally relative to the liquid supply device;
a control device configured to control dropping of the liquid by the liquid supply device and movement of the assay device by the movement device;
said liquid supply device comprising a plurality of containers each configured in the form of an eye dropper;
Each container includes a main body formed so as to be able to contain a liquid, and a nozzle part having a discharge port configured to allow the liquid contained in the main body to drip,
a container mounting mechanism configured to enable the liquid supply device to mount the plurality of containers in a state in which the plurality of containers are horizontally spaced apart from each other while the discharge ports of the plurality of containers face downward; a container pushing mechanism having at least one movable member configured to push the bodies of the plurality of containers to cause the liquid to drip from the discharge port of the container;
The container mounting mechanism has a plurality of container holders each holding the plurality of containers,
Each container holder has a body accommodating portion having a receiving space formed so as to correspond to the main body portion of the container held by the container holder, and a nozzle holding portion holding the nozzle portion of the container held by the container holder. has
The body accommodating portion of each container holder has a passage port that opens so as to allow the movable member that pushes the body portion of the container housed therein to pass therethrough, and the passage port extends through the body accommodation portion. is formed and
The assay system, wherein the controller is configured to control the container pushing mechanism so that the at least one movable member pushes the bodies of the plurality of containers in a desired sequence and timing.
前記制御装置は、前記液体検出装置が各容器の吐出口から滴下される液体を検出したときに、その容器の本体部を押した進出状態から同本体部を押していない後退状態に戻すために、前記容器押し機構を制御するように構成されている、請求項１に記載のアッセイシステム。 A liquid detection device configured to be capable of separately detecting the liquid dropped from the discharge port of the nozzle portion of each of the plurality of containers,
When the liquid detection device detects the liquid dripping from the discharge port of each container, the control device returns from an advanced state in which the main body of the container is pushed to a retracted state in which the main body is not pushed, 3. The assay system of claim 1, configured to control the container pushing mechanism.
前記測定装置は、前記液体供給装置に対して水平方向に離れて配置され、
前記制御装置は、前記液体供給装置から前記アッセイ装置に液体を滴下する滴下区間から、前記測定装置が前記滴下区間にて滴下された液体によって前記アッセイ装置にて得られる反応を測定する測定区間に向けて、前記アッセイ装置を前記液体供給装置及び前記測定装置に対して水平方向に相対的に移動させるべく、前記移動装置を制御するように構成されている、請求項３に記載のアッセイシステム。 A measuring device configured to measure a reaction obtained in the assay device by the liquid dropped from the liquid supply device,
the measuring device is horizontally spaced with respect to the liquid supply device;
The control device moves from a dropping section in which the liquid is dropped from the liquid supply device to the assay device to a measurement section in which the measuring device measures the reaction obtained in the assay device by the liquid dropped in the dropping section. 4. The assay system of claim 3 , configured to control the movement device to orient and move the assay device horizontally relative to the liquid supply device and the measurement device.
前記移動経路は、前記アッセイ装置を前記ステージに設置可能な設置区間を含み、 the movement path includes an installation section capable of installing the assay device on the stage;
前記移動装置は、前記移動経路に沿って前記設置区間と前記滴下区間と前記測定区間の間で前記アッセイ装置を移動させるように構成されている、請求項４に記載のアッセイシステム。 5. The assay system of claim 4, wherein the moving device is configured to move the assay device between the installation section, the dropping section and the measuring section along the movement path.
前記液体供給装置が、前記複数のアッセイモジュールに前記所望の順番及びタイミングで液体を滴下可能とするように構成され、
前記測定装置が、前記液体供給装置から滴下された液体によって前記複数のアッセイモジュールにて得られる反応を所望の順番及びタイミングで測定可能とするように構成され、
前記制御装置は、前記測定装置によって前記複数のアッセイモジュールの反応を測定する前記順番及びタイミングを、前記液体供給装置から前記複数のアッセイモジュールに液体を滴下する前記順番及びタイミングに対して、一定の時間間隔を空けた状態で同じにすべく、前記液体供給装置、前記移動装置、及び前記測定装置を制御するように構成されている、請求項５に記載のアッセイシステム。 The assay device has a plurality of assay modules configured to obtain a reaction with a liquid dripped from the liquid supply device,
wherein the liquid supply device is configured to allow liquid to be dropped onto the plurality of assay modules in the desired order and timing;
The measurement device is configured to be able to measure the reactions obtained in the plurality of assay modules by the liquid dropped from the liquid supply device in a desired order and timing,
The control device sets the order and timing of measuring the reactions of the plurality of assay modules by the measurement device to the order and timing of dropping the liquid from the liquid supply device to the plurality of assay modules. 6. The assay system of claim 5, configured to control the liquid supply device, the movement device, and the measurement device to be the same in a time-spaced manner.
前記移動装置が、前記アッセイ装置を所定の移動経路に沿って移動させることができるように構成され、
前記複数の容器が、これらのノズル部の吐出口を前記アッセイ装置の移動経路に沿って並べるように配置されており、
前記制御装置は、前記複数の可動部材が前記所望の順番及びタイミングで前記複数の容器の本体部をそれぞれ押すために、前記容器押し機構を制御するように構成されている、請求項１に記載のアッセイシステム。 The container pushing mechanism has a plurality of movable members arranged so as to be able to push the main bodies of the plurality of containers, respectively;
wherein the movement device is configured to move the assay device along a predetermined movement path;
The plurality of containers are arranged so that the ejection openings of the nozzle portions are arranged along the movement path of the assay device,
2. The control device according to claim 1, wherein the control device is configured to control the container pushing mechanism so that the plurality of movable members push the main bodies of the plurality of containers in the desired order and timing. assay system.
前記容器押し機構が、前記複数の容器の本体部を各別に押すことができるように構成される１つの前記可動部材を有しており、
前記制御装置は、前記複数の容器が前記１つの可動部材に対応する容器押し位置に前記所望の順番及びタイミングで移動するために、前記容器移動機構を制御するように構成されており、かつ前記１つの可動部材が前記容器移動機構によって移動される前記複数の容器の本体部を前記所望の順番及びタイミングで押すために、前記容器押し機構を制御するように構成されている、請求項１に記載のアッセイシステム。 wherein the liquid supply device includes a container moving mechanism configured to move the plurality of containers relative to the container pushing mechanism;
The container pushing mechanism has one movable member configured to be able to push the main bodies of the plurality of containers individually,
The control device is configured to control the container moving mechanism in order to move the plurality of containers to container pushing positions corresponding to the one movable member in the desired order and timing, and 2. The method according to claim 1, wherein one movable member is configured to control the container pushing mechanism in order to push the main bodies of the plurality of containers moved by the container moving mechanism in the desired order and timing. Assay system as described.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020149810 | 2020-09-07 | ||
| PCT/JP2021/032467 WO2022050384A1 (en) | 2020-09-07 | 2021-09-03 | Assay system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2022050384A1 JPWO2022050384A1 (en) | 2022-03-10 |
| JPWO2022050384A5 true JPWO2022050384A5 (en) | 2023-07-11 |
Family
ID=80491090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022546985A Pending JPWO2022050384A1 (en) | 2020-09-07 | 2021-09-03 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPWO2022050384A1 (en) |
| WO (1) | WO2022050384A1 (en) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4130224A (en) * | 1976-10-08 | 1978-12-19 | Envair, Inc. | Viscous liquid dispenser |
| US4515294A (en) * | 1982-03-31 | 1985-05-07 | Southern Chemical Products Company | Liquid dispenser, valve therefor and process of producing the valve |
| JPS6393373A (en) * | 1986-10-09 | 1988-04-23 | Showa Denko Kk | Liquid droplet forming apparatus |
| JPH0562253U (en) * | 1991-06-04 | 1993-08-20 | 株式会社アルメックス | Drip rate monitor |
| US6092695A (en) * | 1992-05-11 | 2000-07-25 | Cytologix Corporation | Interchangeable liquid dispensing cartridge pump |
| JPH0737051A (en) * | 1993-07-22 | 1995-02-07 | Brother Ind Ltd | Device for notiying of updating time of solution |
| EP2662138A1 (en) * | 2012-05-08 | 2013-11-13 | Roche Diagniostics GmbH | Microfluidic dispenser, cartridge and analysis system for analyzing a biological sample |
| JP6970457B2 (en) * | 2017-09-04 | 2021-11-24 | 国立研究開発法人産業技術総合研究所 | Liquid packaging container and liquid discharge device |
-
2021
- 2021-09-03 WO PCT/JP2021/032467 patent/WO2022050384A1/en active Application Filing
- 2021-09-03 JP JP2022546985A patent/JPWO2022050384A1/ja active Pending
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