JPWO2021257803A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021257803A5 JPWO2021257803A5 JP2022577262A JP2022577262A JPWO2021257803A5 JP WO2021257803 A5 JPWO2021257803 A5 JP WO2021257803A5 JP 2022577262 A JP2022577262 A JP 2022577262A JP 2022577262 A JP2022577262 A JP 2022577262A JP WO2021257803 A5 JPWO2021257803 A5 JP WO2021257803A5
- Authority
- JP
- Japan
- Prior art keywords
- t3ss
- adas
- bacterial cell
- parent bacterial
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010069584 Type III Secretion Systems Proteins 0.000 claims 40
- 210000004027 cell Anatomy 0.000 claims 30
- 230000001580 bacterial effect Effects 0.000 claims 24
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 241000588724 Escherichia coli Species 0.000 claims 5
- 241000588722 Escherichia Species 0.000 claims 4
- 241000607142 Salmonella Species 0.000 claims 4
- 241000607768 Shigella Species 0.000 claims 4
- 241000607598 Vibrio Species 0.000 claims 4
- 241000607734 Yersinia <bacteria> Species 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 230000002759 chromosomal effect Effects 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108091006106 transcriptional activators Proteins 0.000 claims 3
- 241001138501 Salmonella enterica Species 0.000 claims 2
- 241000607762 Shigella flexneri Species 0.000 claims 2
- 108010046504 Type IV Secretion Systems Proteins 0.000 claims 2
- 108010046179 Type VI Secretion Systems Proteins 0.000 claims 2
- 241000607272 Vibrio parahaemolyticus Species 0.000 claims 2
- 241000607447 Yersinia enterocolitica Species 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 210000000805 cytoplasm Anatomy 0.000 claims 2
- 239000002158 endotoxin Substances 0.000 claims 2
- 230000000369 enteropathogenic effect Effects 0.000 claims 2
- 238000010362 genome editing Methods 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- 108700012359 toxins Proteins 0.000 claims 2
- 229940098232 yersinia enterocolitica Drugs 0.000 claims 2
- 108091033409 CRISPR Proteins 0.000 claims 1
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 241000606161 Chlamydia Species 0.000 claims 1
- 108010077544 Chromatin Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 210000003483 chromatin Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000003495 flagella Anatomy 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000006041 probiotic Substances 0.000 claims 1
- 230000000529 probiotic effect Effects 0.000 claims 1
- 235000018291 probiotics Nutrition 0.000 claims 1
- 238000007634 remodeling Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063040457P | 2020-06-17 | 2020-06-17 | |
| US63/040,457 | 2020-06-17 | ||
| US202163147296P | 2021-02-09 | 2021-02-09 | |
| US63/147,296 | 2021-02-09 | ||
| PCT/US2021/037787 WO2021257803A1 (en) | 2020-06-17 | 2021-06-17 | Adas comprising bacterial secretion systems |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023530967A JP2023530967A (ja) | 2023-07-20 |
| JPWO2021257803A5 true JPWO2021257803A5 (pt) | 2024-06-25 |
Family
ID=79268409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022577262A Pending JP2023530967A (ja) | 2020-06-17 | 2021-06-17 | 細菌分泌装置を含むａｄａｓ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230242595A1 (pt) |
| EP (1) | EP4168024A1 (pt) |
| JP (1) | JP2023530967A (pt) |
| AU (1) | AU2021292539A1 (pt) |
| BR (1) | BR112022025633A2 (pt) |
| CA (1) | CA3187263A1 (pt) |
| WO (1) | WO2021257803A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019022539A2 (pt) | 2017-04-28 | 2020-06-16 | Agrospheres, Inc. | Composições e métodos para o encapsulamento e entrega escalonável de agorquímicos |
| US11624061B2 (en) | 2017-04-28 | 2023-04-11 | Agrospheres, Inc. | Compositions and methods for enzyme immobilization |
| BR112020005803A2 (pt) | 2017-09-25 | 2020-12-01 | Agrospheres, Inc. | composições e métodos para produção e administração moduláveis de produtos biológicos |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030166099A1 (en) * | 2001-06-05 | 2003-09-04 | Sabbadini Roger A. | Minicells comprising membrane proteins |
| WO2014138324A1 (en) * | 2013-03-07 | 2014-09-12 | The General Hospital Corporation | Compositions and methods for bacterial delivery of polypeptides |
| US10143743B2 (en) * | 2013-11-18 | 2018-12-04 | Yale University | Non-replicating bacterial nanoparticle delivery system and methods of use |
| WO2015078840A1 (en) * | 2013-11-26 | 2015-06-04 | Boehringer Ingelheim International Gmbh | Full and partial protein secretion and cell surface display using type iii secretion system |
| CA3121520A1 (en) * | 2018-12-10 | 2020-06-18 | Flagship Pioneering Innovations Vi, Llc | Achromosomal dynamic active systems |
-
2021
- 2021-06-17 CA CA3187263A patent/CA3187263A1/en active Pending
- 2021-06-17 JP JP2022577262A patent/JP2023530967A/ja active Pending
- 2021-06-17 BR BR112022025633A patent/BR112022025633A2/pt unknown
- 2021-06-17 EP EP21825340.9A patent/EP4168024A1/en active Pending
- 2021-06-17 US US18/011,008 patent/US20230242595A1/en active Pending
- 2021-06-17 WO PCT/US2021/037787 patent/WO2021257803A1/en unknown
- 2021-06-17 AU AU2021292539A patent/AU2021292539A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Ellison et al. | H-NS represses inv transcription in Yersinia enterocolitica through competition with RovA and interaction with YmoA | |
| Colgan et al. | The impact of 18 ancestral and horizontally-acquired regulatory proteins upon the transcriptome and sRNA landscape of Salmonella enterica serovar Typhimurium | |
| Haack et al. | Interaction of Ler at the LEE5 (tir) operon of enteropathogenic Escherichia coli | |
| Kaushal et al. | Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative σ factor, SigH | |
| Valdez-Cruz et al. | Production of recombinant proteins in E. coli by the heat inducible expression system based on the phage lambda pL and/or pR promoters | |
| Massé et al. | Effect of RyhB small RNA on global iron use in Escherichia coli | |
| Patrick et al. | Swarming motility and the control of master regulators of flagellar biosynthesis | |
| Anderson et al. | Yersinia enterocolitica type III secretion: an mRNA signal that couples translation and secretion of YopQ | |
| Hoffmann et al. | Kinetics of Heat‐Shock Response and Inclusion Body Formation During Temperature‐Induced Production of Basic Fibroblast Growth Factor in High‐Cell‐Density Cultures of Recombinant Escherichiacoli | |
| Skovierova et al. | Identification of the σ E regulon of Salmonella enterica serovar Typhimurium | |
| Shimada et al. | Classification and strength measurement of stationary-phase promoters by use of a newly developed promoter cloning vector | |
| Ma et al. | pH-Dependent modulation of cyclic AMP levels and GadW-dependent repression of RpoS affect synthesis of the GadX regulator and Escherichia coli acid resistance | |
| Kint et al. | The small regulatory RNA molecule MicA is involved in Salmonella enterica serovar Typhimurium biofilm formation | |
| Sandkvist et al. | Secretion of recombinant proteins by Gram-negative bacteria | |
| Cheng et al. | Flagellar basal body structural proteins FlhB, FliM, and FliY are required for flagellar-associated protein expression in Listeria monocytogenes | |
| Vanderpool et al. | Heme-responsive transcriptional activation of Bordetella bhu genes | |
| Weatherspoon-Griffin et al. | Characterization of SlyA in Shigella flexneri identifies a novel role in virulence | |
| Dorman et al. | Control of virulence gene transcription by indirect readout in Vibrio cholerae and Salmonella enterica serovar Typhimurium | |
| Williams McMackin et al. | H-NS family members MvaT and MvaU regulate the Pseudomonas aeruginosa type III secretion system | |
| Li et al. | Analysis of the Salmonella regulatory network suggests involvement of SsrB and H-NS in σE-regulated SPI-2 gene expression | |
| Vogt et al. | Characterization of the Citrobacter rodentium Cpx regulon and its role in host infection | |
| Rossiter et al. | Expression of different bacterial cytotoxins is controlled by two global transcription factors, CRP and Fis, that co-operate in a shared-recruitment mechanism | |
| Boonyom et al. | Salmonella pathogenicity island 1 (SPI-1) type III secretion of SopD involves N-and C-terminal signals and direct binding to the InvC ATPase | |
| Ishihama | Promoter selectivity control of RNA polymerase | |
| Moreno et al. | The regulation of microcin B, C and J operons |