JPWO2021195017A5

JPWO2021195017A5 -

Info

Publication number: JPWO2021195017A5
Application number: JP2022548517A
Authority: JP
Publication date: 2024-04-04

Claims

1. A composition comprising a vapor for administration to the respiratory tract of a subject infected with a respiratory pathogen, comprising:
(a) the vapor is generated by heating an aqueous solution having a pH of 7.0 to 10.0 to a temperature of 35 to 110 degrees Celsius (°C), the aqueous solution comprising an iodine releasing ionic compound and elemental iodine in a total iodine content of 0.5 to 10 ppm;
(b) said administration is for 24 hours or less per day ;
(c) a composition wherein the total iodine delivered to the patient's airway does not exceed 16 mg/kg of body weight per day .

1. A system for treating a subject infected with a respiratory pathogen, comprising:
a container containing an aqueous solution having a pH of 7.0 to 10.0, the aqueous solution comprising an iodine releasing ionic compound and elemental iodine in a total iodine content of 0.5 to 10 ppm;
a heating element configured to heat the aqueous solution in the container to a temperature between 35 and 110 degrees Celsius (°C), thereby generating steam;
a ventilator configured to deliver the vapor such that the vapor reaches the airways of a subject infected with a respiratory pathogen;
wherein the ventilator is configured to administer the vapor for no more than 24 hours per day, and wherein the total iodine delivered to the airways does not exceed 16 mg/kg body weight per day.

1. A dose pack comprising elemental iodine and an iodine-releasing ionic compound, the dose pack being accompanied by instructions for: (a) introducing the dose pack into an aqueous solution having a pH of 7.0-10.0 and a total iodine content of 0.5-10 ppm; (b) warming the aqueous solution to a temperature of 35-110 degrees Celsius (°C), thereby producing a vapor; and (c) administering the vapor to the respiratory tract of a subject infected with a respiratory pathogen, wherein the administration is for no more than 24 hours per day, and wherein the total iodine delivered to the respiratory tract does not exceed 16 mg/kg body weight per day.

An article of manufacture comprising the system of claim 2 and instructions for using the system in administering vapor to the airways of a subject infected with a respiratory pathogen.

2. The composition of claim 1 , wherein the iodine is delivered to the lower respiratory tract of the subject .

2. The composition of claim 1 , wherein the respiratory pathogen is selected from the group consisting of viruses, bacteria, fungi and mycobacteria.

The composition of claim 1 , wherein the respiratory pathogen is a virus.

2. The composition of claim 1 , wherein the respiratory pathogen is COVID-19.

The composition, system, metered dose pack, or article of manufacture of any one of claims 1 to 8, wherein the iodine releasing ionic compound is potassium iodide or povidone iodine.

The composition, system, metered dose pack, or article of manufacture of any one of claims 1 to 9, wherein the vapor is administered simultaneously with an ACE inhibitor, vitamin D, hydroxychloroquine, zinc, a drug selected from a corticosteroid and an anticoagulant, a mouthwash, ivermectin, or a drug that increases intracellular or lysosomal pH in the subject's cells.

The composition, system, metered dose pack, or article of manufacture of any one of claims 1 to 10, wherein the vapor and the target are disposed in an enclosed space.

The composition, system, metered dose pack, or article of manufacture of any one of claims 1 to 11, wherein the vapor is disposed in a respiratory tube.

The composition, system, metered dose pack, or article of manufacture of any one of claims 1 to 11, wherein the vapor is disposed within a respiratory face mask.

The composition, system, metered dose pack, or article of manufacture of any one of claims 1 to 11, wherein the vapor is disposed within nasal prongs.

The composition, system, metered dose pack, or article of manufacture of any one of claims 1 or 3-14, wherein the vapor is disposed within a ventilator.

3. The system of claim 2 , wherein the ventilator is operably coupled to a solution container containing the aqueous solution and a heating element to facilitate evaporation of the aqueous solution.

The generator of claim 2 , wherein the ventilator pressure and frequency are configured to enable the subject to take deep breaths.

3. The generator of claim 2 , wherein the ventilator includes an automatic iodine replenishment system.

3. The generator of claim 2 , wherein the ventilator further comprises an automatic alkali replenishment system.

3. The generator of claim 2 , wherein the ventilator includes an automatic alkali replenishment system.

1. A method for generating steam, the method comprising:
(a) heating an aqueous solution having a pH of 7.0-10.0 to a temperature of 35-110 degrees Celsius (°C), thereby producing steam, said aqueous solution comprising an iodine releasing ionic compound and elemental iodine in a total iodine content of 0.5-10 ppm;
(b) administering the vapor to the subject's airway for no more than 24 hours per day, wherein the total iodine delivered to the airway does not exceed 16 mg/kg body weight per day;
A method comprising: