JPWO2021185738A5

JPWO2021185738A5 -

Info

Publication number: JPWO2021185738A5
Application number: JP2022555775A
Authority: JP
Publication date: 2024-02-27

Description

本概要は、詳細な説明において、下記にさらに説明される簡略化された形態の概念の一部を紹介するために提供される。本概要は、請求される主題の重要な特徴または不可欠な特徴を特定することを意図するものでも、請求される主題の範囲を決定する際の支援として切り離して使用されることも意図するものではない。
本発明は、例えば、以下を提供する。
（項目１）
プローブであって、前記プローブは、
近位端部、遠位端部、および前記近位端部から前記遠位端部まで延びているシャフトを含むシャンクであって、前記シャンクの前記近位端部は、超音波エネルギー源に結合されるように構成され、前記シャンクは、前記シャンクの縦軸と平行な伝搬方向において、前記近位端部から前記遠位端部における先端に前記超音波エネルギーを伝搬するように構成されている、シャンクと、
前記シャフト内の第１の溝であって、前記シャフト内の前記第１の溝は、前記先端に近接して位置付けられている、前記シャフト内の第１の溝と、
前記シャフト内の第２の溝と
を備え、
前記シャフト内の前記第２の溝は、前記第１の溝と前記近位端部との間で前記シャンクに沿って位置付けられ、
前記第１の溝は、前記伝搬方向において、前記シャンクの共振周波数の半波長の第１の整数倍におおよそ等しい第１の距離だけ、前記第２の溝から間隔を置かれている、
プローブ。
（項目２）
前記先端は、前記超音波エネルギーが前記シャンクの前記共振周波数の４分の１波長の奇数倍に対応するとき、第１の変位腹位置と実質的に一致するように、前記近位端部に対して位置付けられている、項目１に記載のプローブ。
（項目３）
前記近位端部は、前記超音波エネルギーが前記４分の１波長の前記奇数倍に対応するとき、第２の変位ノード位置と実質的に一致する点において、前記超音波エネルギー源に結合されるように構成されている、項目２に記載のプローブ。
（項目４）
前記第１の溝は、前記シャフトの非溝付区分によって、前記第２の溝から間隔を置かれている、項目１に記載のプローブ。
（項目５）
前記第１の溝は、前記超音波エネルギーが前記共振周波数の４分の１波長の第１の奇数倍に対応する第１の場所に近接して位置し、前記第２の溝は、前記超音波エネルギーが前記共振周波数の４分の１波長の第２の奇数倍に対応する第２の場所に近接して位置している、項目４に記載のプローブ。
（項目６）
前記第１の溝は、複数の第１の溝の中に含まれ、前記第２の溝は、複数の第２の溝の中に含まれる、項目１に記載のプローブ。
（項目７）
前記複数の第１の溝と前記複数の第２の溝とは、前記シャフトの前記近位端部から前記シャフトの前記遠位端部まで延びている連続した並びで配置されている、項目６に記載のプローブ。
（項目８）
前記シャフトは、前記第２の溝と前記近位端部との間に介在する第３の溝をさらに含み、前記第１の溝は、前記伝搬方向において、前記シャンクの前記共振周波数の半波長の第２の整数倍におおよそ等しい第２の距離だけ、前記第３の溝から間隔を置かれている、項目１に記載のプローブ。
（項目９）
前記シャンクは、前記遠位端部から前記近位端部まで延びている管腔を含み、前記先端は、前記管腔に結合されたポートを含む、項目１に記載のプローブ。
（項目１０）
前記管腔は、外部吸引源に結合されるように構成されている、項目９に記載のプローブ。
（項目１１）
方法であって、前記方法は、
患者の生体組織内にプローブのシャンクを挿入することと、
超音波源に超音波エネルギーを生成させることと、
前記シャンクの縦軸に平行な伝搬方向において、前記シャンクの近位端部から前記シャンクの遠位端部における先端に前記シャンクのシャフトに沿って前記超音波エネルギーを伝搬することと、
前記シャフト内の１つ以上の第１の溝に近接した媒体内で第１のキャビテーション量を生成することと、
前記シャフト内の１つ以上の第２の溝に近接した前記媒体内で第２のキャビテーション量を生成することと
を含み、
前記先端は、前記超音波エネルギーが前記シャンクの共振周波数の４分の１波長の奇数倍に対応するとき、変位腹位置と実質的に一致するように位置付けられ、前記１つ以上の第１の溝は、前記１つ以上の第２の溝から、前記伝搬方向において、ほぼ前記共振周波数の半波長の整数倍の距離に位置付けられている、方法。
（項目１２）
前記超音波源に前記超音波エネルギーを生成させることは、前記第１のキャビテーション量および前記第２のキャビテーション量の空間的場所を変更することを含み、前記変更することは、
第１の時間において、前記共振周波数の前記４分の１波長の第１の奇数倍に対応する第１の超音波エネルギーを生成することと、
前記第１の時間とは異なる第２の時間において、前記共振周波数の前記４分の１波長の第２の奇数倍に対応する第２の超音波エネルギーを生成することと
を前記超音波源に行わせることによる、項目１１に記載の方法。
（項目１３）
前記プローブの前記先端のポートを介して前記患者の生体組織に吸引を印加することを外部吸引源に行わせることをさらに含み、
前記ポートは、前記シャンク内に配置された管腔のための退出口を提供するように構成されている、項目１１に記載の方法。
（項目１４）
超音波プローブであって、前記超音波プローブは、近位端部と、遠位端部と、前記近位端部から前記遠位端部まで延びているシャフトとを含むシャンクを備え、前記近位端部は、超音波エネルギー源に結合されるように構成され、前記シャフトは、第１の複数の溝と、第２の複数の溝と、前記第１の複数の溝と前記第２の複数の溝との間で前記シャフトの縦軸に沿って位置付けられた非溝付区分とを含む、超音波プローブ。
（項目１５）
前記第１の複数の溝のうち少なくとも１つは、前記超音波エネルギーの共振周波数の半波長の整数倍におおよそ等しい前記第２の複数の溝からの距離に位置付けられている、項目１４に記載の超音波プローブ。
（項目１６）
前記非溝付区分における前記シャンクは、第１の直径を伴う外面を有し、前記第１の複数の溝の各々の第１の場所における前記シャフトは、前記第１の直径より小さい第２の直径を有する、項目１５に記載の超音波プローブ。
（項目１７）
前記第２の複数の溝の各々の第２の場所における前記シャフトは、前記第１の直径より小さい第３の直径を有し、前記第２の直径は、前記第３の直径と等しい、項目１６に記載の超音波プローブ。
（項目１８）
前記シャフトは、第１の直径を伴う外面を有し、前記シャフトは、前記外面から突出する複数のフランジを含み、前記第１の複数の溝の各々は、前記複数のフランジの隣接対の間に位置付けられ、前記第１の複数の溝の各々の場所における前記シャフトは、前記第１の直径と等しい第２の直径を有する、項目１４に記載の超音波プローブ。 This Summary is provided to introduce some concepts in a simplified form that are further described below in the Detailed Description. This Summary is not intended to identify key or essential features of the claimed subject matter, nor is it intended to be used in isolation as an aid in determining the scope of the claimed subject matter. do not have.
The present invention provides, for example, the following.
(Item 1)
A probe, the probe comprising:
A shank including a proximal end, a distal end, and a shaft extending from the proximal end to the distal end, the proximal end of the shank coupled to a source of ultrasound energy. and the shank is configured to propagate the ultrasound energy from the proximal end to a tip at the distal end in a propagation direction parallel to a longitudinal axis of the shank. , shank and
a first groove in the shaft, the first groove in the shaft being positioned proximate the tip;
a second groove in the shaft;
Equipped with
the second groove in the shaft is positioned along the shank between the first groove and the proximal end;
the first groove is spaced apart from the second groove in the direction of propagation by a first distance approximately equal to a first integer multiple of a half wavelength of a resonant frequency of the shank;
probe.
(Item 2)
the tip at the proximal end so as to substantially coincide with a first displacement antinode position when the ultrasound energy corresponds to an odd multiple of a quarter wavelength of the resonant frequency of the shank; The probe according to item 1, which is positioned against the probe.
(Item 3)
The proximal end is coupled to the ultrasound energy source at a point that substantially coincides with a second displacement node location when the ultrasound energy corresponds to the odd multiple of the quarter wavelength. The probe according to item 2, wherein the probe is configured to
(Item 4)
The probe of item 1, wherein the first groove is spaced from the second groove by a non-grooved section of the shaft.
(Item 5)
the first groove is located proximate a first location where the ultrasonic energy corresponds to a first odd multiple of a quarter wavelength of the resonant frequency; 5. The probe of item 4, wherein the acoustic wave energy is located proximate a second location corresponding to a second odd multiple of a quarter wavelength of the resonant frequency.
(Item 6)
The probe according to item 1, wherein the first groove is included in a plurality of first grooves, and the second groove is included in a plurality of second grooves.
(Item 7)
Item 6, wherein the plurality of first grooves and the plurality of second grooves are arranged in a continuous line extending from the proximal end of the shaft to the distal end of the shaft. The probe described in.
(Item 8)
The shaft further includes a third groove interposed between the second groove and the proximal end, the first groove having a half wavelength of the resonant frequency of the shank in the propagation direction. The probe of item 1 is spaced from the third groove by a second distance approximately equal to a second integer multiple of .
(Item 9)
The probe of item 1, wherein the shank includes a lumen extending from the distal end to the proximal end, and the tip includes a port coupled to the lumen.
(Item 10)
10. The probe of item 9, wherein the lumen is configured to be coupled to an external suction source.
(Item 11)
A method, the method comprising:
inserting the shank of the probe into the patient's anatomy;
causing an ultrasound source to generate ultrasound energy;
propagating the ultrasonic energy along the shaft of the shank from a proximal end of the shank to a tip at a distal end of the shank in a propagation direction parallel to a longitudinal axis of the shank;
producing a first amount of cavitation in a medium proximate one or more first grooves in the shaft;
producing a second amount of cavitation in the medium proximate one or more second grooves in the shaft;
including;
the tip is positioned to substantially coincide with a displacement antinode position when the ultrasonic energy corresponds to an odd multiple of a quarter wavelength of the resonant frequency of the shank; The groove is located at a distance from the one or more second grooves in the direction of propagation that is approximately an integer multiple of a half wavelength of the resonant frequency.
(Item 12)
causing the ultrasound source to generate the ultrasound energy includes changing the spatial location of the first cavitation amount and the second cavitation amount, the changing comprising:
generating, at a first time, a first ultrasound energy corresponding to a first odd multiple of the quarter wavelength of the resonant frequency;
generating second ultrasonic energy corresponding to a second odd multiple of the quarter wavelength of the resonant frequency at a second time different from the first time;
12. The method according to item 11, by causing the ultrasound source to perform.
(Item 13)
further comprising causing an external suction source to apply suction to the patient's biological tissue through the port at the tip of the probe;
12. The method of item 11, wherein the port is configured to provide an exit for a lumen disposed within the shank.
(Item 14)
The ultrasound probe includes a shank including a proximal end, a distal end, and a shaft extending from the proximal end to the distal end. the distal end is configured to be coupled to a source of ultrasonic energy, and the shaft has a first plurality of grooves, a second plurality of grooves, a first plurality of grooves and a second plurality of grooves. and a non-grooved section positioned along the longitudinal axis of the shaft between a plurality of grooves.
(Item 15)
Item 15, wherein at least one of the first plurality of grooves is located at a distance from the second plurality of grooves approximately equal to an integer multiple of a half wavelength of a resonant frequency of the ultrasonic energy. ultrasonic probe.
(Item 16)
The shank in the non-grooved section has an outer surface with a first diameter, and the shaft at a first location of each of the first plurality of grooves has a second diameter smaller than the first diameter. The ultrasonic probe according to item 15, having a diameter.
(Item 17)
the shaft at a second location of each of the second plurality of grooves has a third diameter that is less than the first diameter, the second diameter being equal to the third diameter; 16. The ultrasonic probe according to 16.
(Item 18)
The shaft has an outer surface with a first diameter, the shaft includes a plurality of flanges projecting from the outer surface, and each of the first plurality of grooves is located between adjacent pairs of the plurality of flanges. 15. The ultrasound probe of item 14, wherein the shaft at each location of the first plurality of grooves has a second diameter equal to the first diameter.

Claims

A probe, the probe comprising:
A shank including a proximal end, a distal end, and a shaft extending from the proximal end to the distal end, the proximal end of the shank being adapted to receive a source of ultrasound energy. and the shank is configured to propagate the ultrasound energy from the proximal end to a tip at the distal end in a propagation direction parallel to a longitudinal axis of the shank. There is a shank,
a first groove in the shaft , the first groove being positioned proximate the tip ;
a second groove in the shaft;
the second groove is positioned along the shank between the first groove and the proximal end;
The first groove is spaced apart from the second groove in the direction of propagation by a first distance approximately equal to a first integer multiple of a half wavelength of a resonant frequency of the shank.

the tip at the proximal end so as to substantially coincide with a first displacement antinode position when the ultrasound energy corresponds to an odd multiple of a quarter wavelength of the resonant frequency of the shank; 2. The probe of claim 1, wherein the probe is positioned against the probe.

the proximal end is coupled to the source of ultrasound energy at a point that substantially coincides with a second displacement node location when the ultrasound energy corresponds to the odd multiple of the quarter wavelength; 3. The probe according to claim 2, wherein the probe is configured to:

The probe of claim 1, wherein the first groove is spaced from the second groove by a non-grooved section of the shaft.

the first groove is located proximate a first location where the ultrasonic energy corresponds to a first odd multiple of a quarter wavelength of the resonant frequency; 5. The probe of claim 4, wherein sonic energy is located proximate a second location corresponding to a second odd multiple of a quarter wavelength of the resonant frequency.

The probe according to claim 1, wherein the first groove is included in a plurality of first grooves, and the second groove is included in a plurality of second grooves.

5. The plurality of first grooves and the plurality of second grooves are arranged in a continuous line extending from the proximal end of the shaft to the distal end of the shaft. 6. The probe according to 6.

The shaft further includes a third groove interposed between the second groove and the proximal end, the first groove having a half wavelength of the resonant frequency of the shank in the propagation direction. The probe of claim 1, wherein the probe is spaced apart from the third groove by a second distance approximately equal to a second integer multiple of .

The probe of claim 1, wherein the shank includes a lumen extending from the distal end to the proximal end, and the tip includes a port coupled to the lumen.

10. The probe of claim 9, wherein the lumen is configured to be coupled to an external source of suction.

A system , the system comprising:
a probe comprising a shank configured to be inserted into biological tissue of a patient;
an ultrasound source configured to generate ultrasound energy ;
Equipped with
the ultrasonic energy is propagated along the shaft of the shank from a proximal end of the shank to a tip at a distal end of the shank in a propagation direction parallel to a longitudinal axis of the shank;
a first amount of cavitation is generated in a medium proximate one or more first grooves in the shaft;
a second amount of cavitation is generated in the medium proximate one or more second grooves in the shaft;
the tip is positioned to substantially coincide with a displacement antinode position when the ultrasonic energy corresponds to an odd multiple of a quarter wavelength of the resonant frequency of the shank; The system , wherein the groove is located at a distance from the one or more second grooves in the direction of propagation that is approximately an integer multiple of half wavelengths of the resonant frequency.

The ultrasound source includes :
generating, at a first time, a first ultrasound energy corresponding to a first odd multiple of the quarter wavelength of the resonant frequency;
generating second ultrasonic energy corresponding to a second odd multiple of the quarter wavelength of the resonant frequency at a second time different from the first time;
12. The system of claim 11 , configured to change the spatial location of the first cavitation amount and the second cavitation amount by .

further comprising an external suction source configured to apply suction to the biological tissue of the patient through the port at the tip of the probe;
12. The system of claim 11, wherein the port is configured to provide an exit for a lumen disposed within the shank.

The ultrasound probe includes a shank including a proximal end, a distal end, and a shaft extending from the proximal end to the distal end. the distal end is configured to be coupled to a source of ultrasonic energy, and the shaft has a first plurality of grooves, a second plurality of grooves, the first plurality of grooves and the second plurality of grooves. and a non-grooved section positioned along the longitudinal axis of the shaft between a plurality of grooves.

15. At least one of the first plurality of grooves is located at a distance from the second plurality of grooves approximately equal to an integer multiple of a half wavelength of a resonant frequency of the ultrasonic energy. Ultrasonic probe as described.

The shank in the non-grooved section has an outer surface with a first diameter, and the shaft at a first location of each of the first plurality of grooves has a second diameter smaller than the first diameter. 16. The ultrasound probe of claim 15, having a diameter.

The shaft at a second location of each of the second plurality of grooves has a third diameter that is less than the first diameter, and the second diameter is equal to the third diameter. 17. The ultrasonic probe according to item 16.

The shaft has an outer surface with a first diameter, the shaft includes a plurality of flanges projecting from the outer surface, and each of the first plurality of grooves is located between adjacent pairs of the plurality of flanges. 15. The ultrasound probe of claim 14, wherein the shaft at each location of the first plurality of grooves has a second diameter equal to the first diameter.