JPWO2021129658A5 - - Google Patents

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JPWO2021129658A5
JPWO2021129658A5 JP2022538928A JP2022538928A JPWO2021129658A5 JP WO2021129658 A5 JPWO2021129658 A5 JP WO2021129658A5 JP 2022538928 A JP2022538928 A JP 2022538928A JP 2022538928 A JP2022538928 A JP 2022538928A JP WO2021129658 A5 JPWO2021129658 A5 JP WO2021129658A5
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JP2023509880A (en
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Priority claimed from PCT/CN2020/138598 external-priority patent/WO2021129658A1/en
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ＤＴＧＲＰＦＶＥＭＹＳＥＩＰＥＩＩＨＭＴＥＧＲＥＬＶＩＰＣＲＶＴＳＰＮＩＴＶＴＬＫＫＦＰＬＤＴＬＩＰＤＧＫＲＩＩＷＤＳＲＫＧＦＩＩＳＮＡＴＹＫＥＩＧＬＬＴＣＥＡＴＶＮＧＨＬＹＫＴＮＹＬＴＨＲＱＴＮＴＩＩＤＶＶＬＳＰＳＨＧＩＥＬＳＶＧＥＫＬＶＬＮＣＴＡＲＴＥＬＮＶＧＩＤＦＮＷＥＹＰＳＳＫＨＱＨＫＫＬＶＮＲＤＬＫＴＱＳＧＳＥＭＫＫＦＬＳＴＬＴＩＤＧＶＴＲＳＤＱＧＬＹＴＣＡＡＳＳＧＬＭＴＫＫＮＳＴＦＶＲＶＨＥＫＤＫＴＨＴＣＰＰＣＰＡＰＥＬＬＧＧＰＳＶＦＬＦＰＰＫＰＫＤＴＬＭＩＳＲＴＰＥＶＴＣＶＶＶＤＶＳＨＥＤＰＥＶＫＦＮＷＹＶＤＧＶＥＶＨＮＡＫＴＫＰＲＥＥＱＹＮＳＴＹＲＶＶＳＶＬＴＶＬＨＱＤＷＬＮＧＫＥＹＫＣＫＶＳＮＫＡＬＰＡＰＩＥＫＴＩＳＫＡＫＧＱＰＲＥＰＱＶＹＴＬＰＰＳＲＤＥＬＴＫＮＱＶＳＬＴＣＬＶＫＧＦＹＰＳＤＩＡＶＥＷＥＳＮＧＱＰＥＮＮＹＫＴＴＰＰＶＬＤＳＤＧＳＦＦＬＹＳＫＬＴＶＤＫＳＲＷＱＱＧＮＶＦＳＣＳＶＭＨＥＡＬＨＮＨＹＴＱＫＳＬＳＬＳＰＧＫＧＧＧＧＧＧＱＣＮＡＰＥＷＬＰＦＡＲＰＴＮＬＴＤＥＦＥＦＰＩＧＴＹＬＫＹＥＣＲＰＧＹＹＧＲＰＦＳＩＩＣＬＫＮＳＶＷＴＧＡＫＤＲＣＲＲＫＳＣＲＮＰＰＤＰＶＮＧＭＶＨＶＩＫＤＩＱＦＧＳＱＩＫＹＳＣＴＫＧＹＲＬＩＧＳＳＳＡＴＣＩＩＳＧＮＴＶＩＷＤＮＥＴＰＩＣＤＲＩＰＣＧＬＰＰＴＩＴＮＧＤＦＩＳＴＮＲＥＮＦＨＹＧＳＶＶＴＹＲＣＮＰＧＳＧＧＲＫＶＦＥＬＶＧＥＰＳＩＹＣＴＳＮＤＤＱＶＧＩＷＳＧＰＡＰＱＣＩ（配列番号１）。 DTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGK R. IIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTF VRVHEKDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPSRDELT KNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVVMHEALHNHYTQKSLSLSPGKGGGGGGQCNAPEWLPFARPTNLTDEFEFPIGTYLKYECRPGYYGRPFSIICLKNSVWTGAKDR CRRKSCRNPPDPVNGMVHVIKDIQFGSQIKYSCTKGYRLIGSSSATCIISGNTVIWDNETPICDRIPCGLPPTINGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI (SEQ ID NO: 1).

ＤＴＧＲＰＦＶＥＭＹＳＥＩＰＥＩＩＨＭＴＥＧＲＥＬＶＩＰＣＲＶＴＳＰＮＩＴＶＴＬＫＫＦＰＬＤＴＬＩＰＤＧＫＲＩＩＷＤＳＲＫＧＦＩＩＳＮＡＴＹＫＥＩＧＬＬＴＣＥＡＴＶＮＧＨＬＹＫＴＮＹＬＴＨＲＱＴＮＴＩＩＤＶＶＬＳＰＳＨＧＩＥＬＳＶＧＥＫＬＶＬＮＣＴＡＲＴＥＬＮＶＧＩＤＦＮＷＥＹＰＳＳＫＨＱＨＫＫＬＶＮＲＤＬＫＴＱＳＧＳＥＭＫＫＦＬＳＴＬＴＩＤＧＶＴＲＳＤＱＧＬＹＴＣＡＡＳＳＧＬＭＴＫＫＮＳＴＦＶＲＶＨＥＫＤＫＴＨＴＣＰＰＣＰＡＰＥＬＬＧＧＰＳＶＦＬＦＰＰＫＰＫＤＴＬＭＩＳＲＴＰＥＶＴＣＶＶＶＤＶＳＨＥＤＰＥＶＫＦＮＷＹＶＤＧＶＥＶＨＮＡＫＴＫＰＲＥＥＱＹＮＳＴＹＲＶＶＳＶＬＴＶＬＨＱＤＷＬＮＧＫＥＹＫＣＫＶＳＮＫＡＬＰＡＰＩＥＫＴＩＳＫＡＫＧＱＰＲＥＰＱＶＹＴＬＰＰＳＲＤＥＬＴＫＮＱＶＳＬＴＣＬＶＫＧＦＹＰＳＤＩＡＶＥＷＥＳＮＧＱＰＥＮＮＹＫＴＴＰＰＶＬＤＳＤＧＳＦＦＬＹＳＫＬＴＶＤＫＳＲＷＱＱＧＮＶＦＳＣＳＶＭＨＥＡＬＨＮＨＹＴＱＫＳＬＳＬＳＰＧＫＧＧＧＧＧＧＱＣＮＡＰＥＷＬＰＦＡＲＰＴＮＬＴＤＥＦＥＦＰＩＧＴＹＬＫＹＥＣＲＰＧＹＹＧＲＰＦＳＩＩＣＬＫＮＳＶＷＴＧＡＫＤＲＣＲＲＫＳＣＲＮＰＰＤＰＶＮＧＭＶＨＶＩＫＤＩＱＦＧＳＱＩＫＹＳＣＴＫＧＹＲＬＩＧＳＳＳＡＴＣＩＩＳＧＮＴＶＩＷＤＮＥＴＰＩＣＤＲＩＰＣＧＬＰＰＴＩＴＮＧＤＦＩＳＴＮＲＥＮＦＨＹＧＳＶＶＴＹＲＣＮＰＧＳＧＧＲＫＶＦＥＬＶＧＥＰＳＩＹＣＴＳＮＤＤＱＶＧＩＷＳＧＰＡＰＱＣＩ（配列番号１）。 DTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGK R. IIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTF VRVHEKDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPSRDELT KNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVVMHEALHNHYTQKSLSLSPGKGGGGGGQCNAPEWLPFARPTNLTDEFEFPIGTYLKYECRPGYYGRPFSIICLKNSVWTGAKDR CRRKSCRNPPDPVNGMVHVIKDIQFGSQIKYSCTKGYRLIGSSSATCIISGNTVIWDNETPICDRIPCGLPPTINGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI (SEQ ID NO: 1).

ＤＴＧＲＰＦＶＥＭＹＳＥＩＰＥＩＩＨＭＴＥＧＲＥＬＶＩＰＣＲＶＴＳＰＮＩＴＶＴＬＫＫＦＰＬＤＴＬＩＰＤＧＫＲＩＩＷＤＳＲＫＧＦＩＩＳＮＡＴＹＫＥＩＧＬＬＴＣＥＡＴＶＮＧＨＬＹＫＴＮＹＬＴＨＲＱＴＮＴＩＩＤＶＶＬＳＰＳＨＧＩＥＬＳＶＧＥＫＬＶＬＮＣＴＡＲＴＥＬＮＶＧＩＤＦＮＷＥＹＰＳＳＫＨＱＨＫＫＬＶＮＲＤＬＫＴＱＳＧＳＥＭＫＫＦＬＳＴＬＴＩＤＧＶＴＲＳＤＱＧＬＹＴＣＡＡＳＳＧＬＭＴＫＫＮＳＴＦＶＲＶＨＥＫＤＫＴＨＴＣＰＰＣＰＡＰＥＬＬＧＧＰＳＶＦＬＦＰＰＫＰＫＤＴＬＭＩＳＲＴＰＥＶＴＣＶＶＶＤＶＳＨＥＤＰＥＶＫＦＮＷＹＶＤＧＶＥＶＨＮＡＫＴＫＰＲＥＥＱＹＮＳＴＹＲＶＶＳＶＬＴＶＬＨＱＤＷＬＮＧＫＥＹＫＣＫＶＳＮＫＡＬＰＡＰＩＥＫＴＩＳＫＡＫＧＱＰＲＥＰＱＶＹＴＬＰＰＳＲＤＥＬＴＫＮＱＶＳＬＴＣＬＶＫＧＦＹＰＳＤＩＡＶＥＷＥＳＮＧＱＰＥＮＮＹＫＴＴＰＰＶＬＤＳＤＧＳＦＦＬＹＳＫＬＴＶＤＫＳＲＷＱＱＧＮＶＦＳＣＳＶＭＨＥＡＬＨＮＨＹＴＱＫＳＬＳＬＳＰＧＫＧＧＧＧＧＧＱＣＮＡＰＥＷＬＰＦＡＲＰＴＮＬＴＤＥＦＥＦＰＩＧＴＹＬＫＹＥＣＲＰＧＹＹＧＲＰＦＳＩＩＣＬＫＮＳＶＷＴＧＡＫＤＲＣＲＲＫＳＣＲＮＰＰＤＰＶＮＧＭＶＨＶＩＫＤＩＱＦＧＳＱＩＫＹＳＣＴＫＧＹＲＬＩＧＳＳＳＡＴＣＩＩＳＧＮＴＶＩＷＤＮＥＴＰＩＣＤＲＩＰＣＧＬＰＰＴＩＴＮＧＤＦＩＳＴＮＲＥＮＦＨＹＧＳＶＶＴＹＲＣＮＰＧＳＧＧＲＫＶＦＥＬＶＧＥＰＳＩＹＣＴＳＮＤＤＱＶＧＩＷＳＧＰＡＰＱＣＩ（配列番号１）。 DTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGK R. IIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTF VRVHEKDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPSRDELT KNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVVMHEALHNHYTQKSLSLSPGKGGGGGGQCNAPEWLPFARPTNLTDEFEFPIGTYLKYECRPGYYGRPFSIICLKNSVWTGAKDR CRRKSCRNPPDPVNGMVHVIKDIQFGSQIKYSCTKGYRLIGSSSATCIISGNTVIWDNETPICDRIPCGLPPTINGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI (SEQ ID NO: 1).

JP2022538928A 2019-12-24 2020-12-23 Use of fusion proteins in the treatment of age-related macular degeneration Pending JP2023509880A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201911346311 2019-12-24
CN201911346311.2 2019-12-24
CN202011441025 2020-12-11
CN202011441025.7 2020-12-11
PCT/CN2020/138598 WO2021129658A1 (en) 2019-12-24 2020-12-23 Application of fusion protein in treating age-related macular degeneration

Publications (2)

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JP2023509880A JP2023509880A (en) 2023-03-10
JPWO2021129658A5 true JPWO2021129658A5 (en) 2023-06-05

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JP2022538928A Pending JP2023509880A (en) 2019-12-24 2020-12-23 Use of fusion proteins in the treatment of age-related macular degeneration

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US (1) US20230056821A1 (en)
EP (1) EP4082559A4 (en)
JP (1) JP2023509880A (en)
CN (1) CN114867489A (en)
AU (1) AU2020414152A1 (en)
CA (1) CA3165887A1 (en)
TW (1) TW202128746A (en)
WO (1) WO2021129658A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117467025B (en) * 2023-12-28 2024-04-16 上海鼎新基因科技有限公司 anti-VEGF and complement bifunctional fusion protein and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2785744B1 (en) * 2011-12-01 2017-10-04 AP Biosciences, Inc. Protein inhibitors to complement and vegf pathways and methods of use thereof
CN105435222B (en) * 2014-09-25 2018-05-29 信达生物制药(苏州)有限公司 Recombination fusion protein preparation
CN104940926B (en) * 2014-09-25 2017-09-22 信达生物制药(苏州)有限公司 Recombination fusion protein preparation

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