JPWO2021113658A5 - - Google Patents
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- JPWO2021113658A5 JPWO2021113658A5 JP2022534348A JP2022534348A JPWO2021113658A5 JP WO2021113658 A5 JPWO2021113658 A5 JP WO2021113658A5 JP 2022534348 A JP2022534348 A JP 2022534348A JP 2022534348 A JP2022534348 A JP 2022534348A JP WO2021113658 A5 JPWO2021113658 A5 JP WO2021113658A5
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- 241000894006 Bacteria Species 0.000 claims description 85
- 230000001580 bacterial effect Effects 0.000 claims description 47
- 230000001013 cariogenic effect Effects 0.000 claims description 21
- 208000002925 dental caries Diseases 0.000 claims description 17
- 241000894007 species Species 0.000 claims description 16
- 241000711295 Aeria Species 0.000 claims description 14
- 241000186660 Lactobacillus Species 0.000 claims description 10
- 241000194019 Streptococcus mutans Species 0.000 claims description 9
- 229940039696 lactobacillus Drugs 0.000 claims description 9
- 241000282414 Homo sapiens Species 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- 241000186840 Lactobacillus fermentum Species 0.000 claims description 5
- 241000186869 Lactobacillus salivarius Species 0.000 claims description 5
- 241000960363 Streptococcus infantis Species 0.000 claims description 5
- 241000193987 Streptococcus sobrinus Species 0.000 claims description 5
- 230000001332 colony forming effect Effects 0.000 claims description 4
- 241000194023 Streptococcus sanguinis Species 0.000 claims description 3
- 235000002198 Annona diversifolia Nutrition 0.000 claims description 2
- 241000283690 Bos taurus Species 0.000 claims description 2
- 241000282836 Camelus dromedarius Species 0.000 claims description 2
- 241000283707 Capra Species 0.000 claims description 2
- 241000700199 Cavia porcellus Species 0.000 claims description 2
- 241000282693 Cercopithecidae Species 0.000 claims description 2
- 241000283074 Equus asinus Species 0.000 claims description 2
- 241000283073 Equus caballus Species 0.000 claims description 2
- 241000282326 Felis catus Species 0.000 claims description 2
- 241000282575 Gorilla Species 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 2
- 241000282577 Pan troglodytes Species 0.000 claims description 2
- 241001494479 Pecora Species 0.000 claims description 2
- 241000009328 Perro Species 0.000 claims description 2
- 241000700159 Rattus Species 0.000 claims description 2
- 241000282898 Sus scrofa Species 0.000 claims description 2
- 230000002238 attenuated effect Effects 0.000 claims description 2
- 241000282842 Lama glama Species 0.000 claims 1
- 241000203719 Rothia dentocariosa Species 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 description 54
- 241000557476 Streptococcus sanguinis SK36 Species 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
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- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 2
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
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Description
等価物
当業者は、本明細書に記載された本発明の具体的な実施形態に対する多くの等価物を認識するはずであり、又は、通常行われる実験を用いるだけでそれらを確かめることができるはずである。そのような等価物は、以下の特許請求の範囲によって包含されるものとする。
例えば、本発明は以下の実施形態を包含する:
[実施形態1]ロシア・デントカリオーサ種の細菌、ロシア・アエリア種の細菌、又はこれらの組合せを含む治療有効量の細菌組成物を対象に投与することを含む、対象におけるう蝕を予防する方法。
[実施形態2]細菌組成物が、う蝕原性細菌による酸産生を阻害することによってう蝕を予防する、実施形態1に記載の方法。
[実施形態3]細菌組成物がう蝕原性細菌の増殖を阻害しない、実施形態1又は2に記載の方法。
[実施形態4]う蝕原性細菌が、ストレプトコッカス・ミュータンス種、ストレプトコッカス・インファンティス種、ストレプトコッカス・サングイニスSK36種、又はストレプトコッカス・ソブリナス種の細菌である、実施形態1から3のいずれかに記載の方法。
[実施形態5]ストレプトコッカス・ミュータンス種の細菌が、ATCC UA140株又はATCC UA159株の細菌である、実施形態4に記載の方法。
[実施形態6]う蝕原性細菌がラクトバチルス属の細菌である、実施形態1から3のいずれかに記載の方法。
[実施形態7]ラクトバチルス属の細菌が、ラクトバチルス・ファーメンタム種及びラクトバチルス・サリバリウス種の細菌である、実施形態6に記載の方法。
[実施形態8]対象がう蝕を発生するリスクを有する、実施形態1から7のいずれかに記載の方法。
[実施形態9]ロシア・デントカリオーサ種の細菌、ロシア・アエリア種の細菌、又はこれらの組合せを含む治療有効量の細菌組成物を対象に投与することを含む、対象におけるう蝕を処置する又はその重症度を低減する方法。
[実施形態10]細菌組成物が、う蝕原性細菌による酸産生を阻害することによってう蝕を処置する又はその重症度を低減する、実施形態9に記載の方法。
[実施形態11]細菌組成物がう蝕原性細菌の増殖を阻害しない、実施形態9又は10に記載の方法。
[実施形態12]う蝕原性細菌が、ストレプトコッカス・ミュータンス種、ストレプトコッカス・インファンティス種、ストレプトコッカス・サングイニスSK36種、又はストレプトコッカス・ソブリナス種の細菌である、実施形態9から11のいずれかに記載の方法。
[実施形態13]ストレプトコッカス・ミュータンス種の細菌が、ATCC UA140株又はATCC UA159株の細菌である、実施形態12に記載の方法。
[実施形態14]う蝕原性細菌がラクトバチルス属の細菌である、実施形態9から11のいずれかに記載の方法。
[実施形態15]ラクトバチルス属の細菌が、ラクトバチルス・ファーメンタム種及びラクトバチルス・サリバリウス種の細菌である、実施形態14に記載の方法。
[実施形態16]細菌組成物中の細菌の少なくとも50%が、ロシア・デントカリオーサ種、ロシア・アエリア種、又はこれらの組合せの細菌である、実施形態1から15のいずれかに記載の方法。
[実施形態17]細菌組成物中の細菌の少なくとも90%が、ロシア・デントカリオーサ種、ロシア・アエリア種、又はこれらの組合せの細菌である、実施形態1から16のいずれかに記載の方法。
[実施形態18]細菌組成物中の細菌の実質的にすべてが、ロシア・デントカリオーサ種、ロシア・アエリア種、又はこれらの組合せの細菌である、実施形態1から17のいずれかに記載の方法。
[実施形態19]細菌組成物が、少なくとも1×10
6
コロニー形成単位(CFU)のロシア・デントカリオーサ種、ロシア・アエリア種、又はこれらの組合せの細菌を含む、実施形態1から15のいずれかに記載の方法。
[実施形態20]ロシア属の細菌を含む細菌組成物を対象に投与することを含む、対象におけるう蝕原性細菌による酸産生を阻害する方法。
[実施形態21]細菌組成物が、ロシア・デントカリオーサ種の細菌、ロシア・アエリアの細菌、及びロシア・ムシラギノーサの細菌から選択される少なくとも1種の細菌を含む、実施形態20に記載の方法。
[実施形態22]細菌組成物がう蝕原性細菌の増殖を阻害しない、実施形態20又は21に記載の方法。
[実施形態23]う蝕原性細菌が、ストレプトコッカス・ミュータンス種、ストレプトコッカス・インファンティス種、ストレプトコッカス・サングイニスSK36種、又はストレプトコッカス・ソブリナス種の細菌である、実施形態20から22のいずれかに記載の方法。
[実施形態24]ストレプトコッカス・ミュータンス種の細菌が、ATCC UA140株又はATCC UA159株の細菌である、実施形態23に記載の方法。
[実施形態25]う蝕原性細菌がラクトバチルス属の細菌である、実施形態20から22のいずれかに記載の方法。
[実施形態26]ラクトバチルス属の細菌が、ラクトバチルス・ファーメンタム種及びラクトバチルス・サリバリウス種の細菌である、実施形態25に記載の方法。
[実施形態27]対象がう蝕の発生するリスクを有する、実施形態20から26のいずれかに記載の方法。
[実施形態28]細菌組成物が対象におけるう蝕を予防する、実施形態20から27のいずれかに記載の方法。
[実施形態29]対象がう蝕に罹患している、実施形態20から26のいずれかに記載の方法。
[実施形態30]細菌組成物が対象におけるう蝕を処置するはその重症度を低減する、実施形態29に記載の方法。
[実施形態31]細菌組成物中の細菌の少なくとも50%がロシア属の細菌である、実施形態1から30のいずれかに記載の方法。
[実施形態32]細菌組成物中の細菌の少なくとも90%がロシア属の細菌である、実施形態1から31のいずれかに記載の方法。
[実施形態33]細菌組成物中の細菌の実質的にすべてがロシア属の細菌である、実施形態1から32のいずれかに記載の方法。
[実施形態34]細菌組成物が、少なくとも1×10
6
コロニー形成単位(CFU)のロシア属の細菌を含む、実施形態1から30のいずれかに記載の方法。
[実施形態35]細菌組成物が経口投与される、実施形態1から34のいずれかに記載の方法。
[実施形態36]細菌組成物が2回以上の用量で投与される、実施形態1から35のいずれかに記載の方法。
[実施形態37]対象への2回以上の用量での投与が少なくとも1日隔てられている、実施形態36に記載の方法。
[実施形態38]2回以上の用量での投与が少なくとも1週間隔てられている、実施形態37に記載の方法。
[実施形態39]細菌組成物が生きた細菌を含む、実施形態1から38のいずれかに記載の方法。
[実施形態40]細菌組成物が弱毒化された細菌を含む、実施形態39に記載の方法。
[実施形態41]細菌組成物が死滅した細菌を含む、実施形態1から38のいずれかに記載の方法。
[実施形態42]う蝕を予防する、処置する、及び/又はその重症度を低減する第2の治療薬を対象に投与することをさらに含む、実施形態1から41のいずれかに記載の方法。
[実施形態43]第2の治療薬が、う蝕原性細菌の増殖を阻害する第2の細菌組成物を対象に投与することを含む、実施形態1から42のいずれかに記載の方法。
[実施形態44]う蝕原性細菌が、ストレプトコッカス・ミュータンス種、ストレプトコッカス・インファンティス種、ストレプトコッカス・サングイニスSK36種、又はストレプトコッカス・ソブリナス種の細菌である、実施形態1から43のいずれかに記載の方法。
[実施形態45]う蝕原性細菌がラクトバチルス属の細菌である、実施形態1から43のいずれかに記載の方法。
[実施形態46]ラクトバチルス属の細菌が、ラクトバチルス・ファーメンタム種及びラクトバチルス・サリバリウス種の細菌である、実施形態45に記載の方法。
[実施形態47]プレバイオティクスを対象に投与することをさらに含む、実施形態1から46のいずれかに記載の方法。
[実施形態48]プレバイオティクスが、フルクトオリゴ糖、ガラクトオリゴ糖、トランスガラクトオリゴ糖、キシロオリゴ糖、キトオリゴ糖、大豆オリゴ糖、ゲンチオオリゴ糖、イソマルトオリゴ糖、マンノオリゴ糖、マルトオリゴ糖、マンナンオリゴ糖、ラクツロース、ラクトスクロース、パラチノース、グリコシルスクロース、グアーガム、アラビアゴム、タガロース、アミロース、アミロペクチン、ペクチン、キシラン、又はシクロデキストリンである、実施形態47に記載の方法。
[実施形態49]対象が哺乳動物である、実施形態1から48のいずれかに記載の方法。
[実施形態50]哺乳動物が、イヌ、ネコ、ウシ、ウマ、ブタ、ロバ、ヤギ、ラクダ、マウス、ラット、モルモット、ヒツジ、ラマ、サル、ゴリラ、チンパンジー又はヒトからなる群から選択される、実施形態49に記載の方法。
[実施形態51]哺乳動物がヒトである、実施形態50に記載の方法。
[実施形態52]ヒトが子供である、実施形態51に記載の方法。
Equivalents Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. It is. Such equivalents are intended to be covered by the following claims.
For example, the invention encompasses the following embodiments:
[Embodiment 1] Preventing dental caries in a subject, comprising administering to the subject a therapeutically effective amount of a bacterial composition comprising bacteria of the species Dentocariosa russianus, bacteria of the species Aeria russia, or a combination thereof. Method.
[Embodiment 2] The method of Embodiment 1, wherein the bacterial composition prevents caries by inhibiting acid production by cariogenic bacteria.
[Embodiment 3] The method according to Embodiment 1 or 2, wherein the bacterial composition does not inhibit the growth of cariogenic bacteria.
[Embodiment 4] Any one of Embodiments 1 to 3, wherein the cariogenic bacteria are Streptococcus mutans species, Streptococcus infantis species, Streptococcus sanguinis SK36 species, or Streptococcus sobrinus species. Method described.
[Embodiment 5] The method according to Embodiment 4, wherein the Streptococcus mutans species bacterium is an ATCC UA140 strain or an ATCC UA159 strain.
[Embodiment 6] The method according to any one of Embodiments 1 to 3, wherein the cariogenic bacterium is a bacterium of the genus Lactobacillus.
[Embodiment 7] The method according to Embodiment 6, wherein the Lactobacillus bacteria are Lactobacillus fermentum species and Lactobacillus salivarius species.
[Embodiment 8] The method according to any one of Embodiments 1 to 7, wherein the subject has a risk of developing dental caries.
[Embodiment 9] Treating dental caries in a subject, comprising administering to the subject a therapeutically effective amount of a bacterial composition comprising bacteria of the species Dentocariosa Russianis, bacteria of the species Aeria Russianus, or a combination thereof. or a method of reducing its severity.
[Embodiment 10] The method of embodiment 9, wherein the bacterial composition treats or reduces the severity of dental caries by inhibiting acid production by cariogenic bacteria.
[Embodiment 11] The method according to Embodiment 9 or 10, wherein the bacterial composition does not inhibit the growth of cariogenic bacteria.
[Embodiment 12] Any one of Embodiments 9 to 11, wherein the cariogenic bacteria are Streptococcus mutans species, Streptococcus infantis species, Streptococcus sanguinis SK36 species, or Streptococcus sobrinus species. Method described.
[Embodiment 13] The method according to Embodiment 12, wherein the Streptococcus mutans species bacterium is an ATCC UA140 strain or an ATCC UA159 strain.
[Embodiment 14] The method according to any one of Embodiments 9 to 11, wherein the cariogenic bacterium is a bacterium of the genus Lactobacillus.
[Embodiment 15] The method according to Embodiment 14, wherein the bacteria of the genus Lactobacillus are bacteria of the species Lactobacillus fermentum and Lactobacillus salivarius.
[Embodiment 16] The method according to any of embodiments 1 to 15, wherein at least 50% of the bacteria in the bacterial composition are bacteria of the species Russian dentocariosa, the species Aeria Russian, or a combination thereof. .
[Embodiment 17] The method according to any of embodiments 1 to 16, wherein at least 90% of the bacteria in the bacterial composition are bacteria of the Russian dentocariosa species, the Russian aeria species, or a combination thereof. .
[Embodiment 18] The method according to any one of embodiments 1 to 17, wherein substantially all of the bacteria in the bacterial composition are bacteria of the Russian dentocariosa species, the Russian aeria species, or a combination thereof. Method.
[Embodiment 19] Any of embodiments 1 to 15, wherein the bacterial composition comprises at least 1 x 10 colony forming units (CFU) of bacteria of Russian dentocariosa species, Russian aeria species, or a combination thereof. Method described in Crab.
[Embodiment 20] A method for inhibiting acid production by cariogenic bacteria in a subject, the method comprising administering to the subject a bacterial composition containing a bacterium belonging to the genus Russian.
[Embodiment 21] The method according to Embodiment 20, wherein the bacterial composition comprises at least one type of bacteria selected from bacteria of the species Russian dentocariosa, bacteria of Russian aeria, and bacteria of Russian mucilaginosa. .
[Embodiment 22] The method according to Embodiment 20 or 21, wherein the bacterial composition does not inhibit the growth of cariogenic bacteria.
[Embodiment 23] Any one of Embodiments 20 to 22, wherein the cariogenic bacteria are Streptococcus mutans species, Streptococcus infantis species, Streptococcus sanguinis species SK36, or Streptococcus sobrinus species. Method described.
[Embodiment 24] The method according to Embodiment 23, wherein the Streptococcus mutans species bacterium is an ATCC UA140 strain or an ATCC UA159 strain.
[Embodiment 25] The method according to any one of Embodiments 20 to 22, wherein the cariogenic bacterium is a bacterium of the genus Lactobacillus.
[Embodiment 26] The method according to Embodiment 25, wherein the bacteria of the genus Lactobacillus are bacteria of the species Lactobacillus fermentum and Lactobacillus salivarius.
[Embodiment 27] The method according to any one of Embodiments 20 to 26, wherein the subject has a risk of developing dental caries.
[Embodiment 28] The method of any of embodiments 20-27, wherein the bacterial composition prevents caries in the subject.
[Embodiment 29] The method according to any one of Embodiments 20 to 26, wherein the subject is suffering from dental caries.
[Embodiment 30] The method of embodiment 29, wherein the bacterial composition treats or reduces the severity of dental caries in the subject.
[Embodiment 31] The method according to any of embodiments 1 to 30, wherein at least 50% of the bacteria in the bacterial composition are bacteria of the genus Russi.
[Embodiment 32] The method according to any of embodiments 1 to 31, wherein at least 90% of the bacteria in the bacterial composition are bacteria of the genus Russi.
[Embodiment 33] The method according to any one of Embodiments 1 to 32, wherein substantially all of the bacteria in the bacterial composition are bacteria of the genus Rossi.
[Embodiment 34] The method of any of embodiments 1 to 30, wherein the bacterial composition comprises at least 1 x 106 colony forming units (CFU) of bacteria of the genus Russi.
[Embodiment 35] The method according to any of embodiments 1 to 34, wherein the bacterial composition is administered orally.
[Embodiment 36] The method of any of embodiments 1-35, wherein the bacterial composition is administered in two or more doses.
[Embodiment 37] The method of Embodiment 36, wherein the administration of the two or more doses to the subject is at least one day apart.
[Embodiment 38] The method of Embodiment 37, wherein the administration of the two or more doses is separated by at least one week.
[Embodiment 39] The method of any of embodiments 1-38, wherein the bacterial composition comprises live bacteria.
[Embodiment 40] The method of embodiment 39, wherein the bacterial composition comprises attenuated bacteria.
[Embodiment 41] The method of any of embodiments 1 to 38, wherein the bacterial composition comprises killed bacteria.
[Embodiment 42] The method of any of Embodiments 1 to 41, further comprising administering to the subject a second therapeutic agent that prevents, treats, and/or reduces the severity of dental caries. .
[Embodiment 43] The method according to any one of Embodiments 1 to 42, wherein the second therapeutic agent comprises administering to the subject a second bacterial composition that inhibits the growth of cariogenic bacteria.
[Embodiment 44] Any one of Embodiments 1 to 43, wherein the cariogenic bacteria are Streptococcus mutans species, Streptococcus infantis species, Streptococcus sanguinis species SK36, or Streptococcus sobrinus species. Method described.
[Embodiment 45] The method according to any one of Embodiments 1 to 43, wherein the cariogenic bacterium is a bacterium of the genus Lactobacillus.
[Embodiment 46] The method according to Embodiment 45, wherein the bacteria of the genus Lactobacillus are bacteria of the species Lactobacillus fermentum and Lactobacillus salivarius.
[Embodiment 47] The method according to any of Embodiments 1 to 46, further comprising administering a prebiotic to the subject.
[Embodiment 48] The prebiotics are fructooligosaccharides, galactooligosaccharides, transgalactooligosaccharides, xylooligosaccharides, chitooligosaccharides, soybean oligosaccharides, gentiooligosaccharides, isomaltooligosaccharides, mannooligosaccharides, maltooligosaccharides, mannanoligosaccharides, lactulose, lactulose 48. The method of embodiment 47, which is sucrose, palatinose, glycosylsucrose, guar gum, gum arabic, tagalose, amylose, amylopectin, pectin, xylan, or cyclodextrin.
[Embodiment 49] The method according to any one of Embodiments 1 to 48, wherein the subject is a mammal.
[Embodiment 50] The mammal is selected from the group consisting of a dog, cat, cow, horse, pig, donkey, goat, camel, mouse, rat, guinea pig, sheep, llama, monkey, gorilla, chimpanzee or human. 50. The method of embodiment 49.
[Embodiment 51] The method of embodiment 50, wherein the mammal is a human.
[Embodiment 52] The method of embodiment 51, wherein the human is a child.
Claims (32)
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US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
US11672835B2 (en) | 2013-12-20 | 2023-06-13 | Seed Health, Inc. | Method for treating individuals having cancer and who are receiving cancer immunotherapy |
US11642382B2 (en) | 2013-12-20 | 2023-05-09 | Seed Health, Inc. | Method for treating an individual suffering from bladder cancer |
US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
US11529379B2 (en) | 2013-12-20 | 2022-12-20 | Seed Health, Inc. | Method and system for reducing the likelihood of developing colorectal cancer in an individual human being |
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