JPWO2021113206A5 - - Google Patents

Claims (24)

an isolated avian reovirus, said isolated avian reovirus being avian reovirus strain 94826 C140 deposited with the ATCC under patent designation PTA-126077, or a progeny or derivative thereof; An isolated avian reovirus whose progeny or derivatives have essentially the same biological and serological characteristics as said avian reovirus strain 94826 C140 deposited with the ATCC under patent designation PTA-126077. an isolated avian reovirus, said isolated avian reovirus being avian reovirus strain 96139 C140 deposited with the ATCC under patent designation PTA-126078, or a progeny or derivative thereof; An isolated avian reovirus whose progeny or derivatives have essentially the same biological and serological characteristics as said avian reovirus 96139 C140 strain deposited with the ATCC under patent designation PTA-126078. 3. The isolated avian reovirus of claim 1 or 2, wherein the isolated avian reovirus comprises a master seed virus. The isolated avian reovirus according to any one of claims 1 to 3, wherein the isolated avian reovirus is lyophilized, freeze-dried, frozen , or in an effervescent tablet. A composition comprising an isolated avian reovirus according to any one of claims 1 to 4. 6. A composition according to claim 5, further comprising an adjuvant and/or a pharmaceutically acceptable carrier . 7. A composition according to claim 5 or 6 , formulated for intranasal, intraocular, oral, mucosal, intramuscular, subcutaneous, or in ovo administration, or for spraying or aerosolization . A vaccine comprising an isolated avian reovirus according to any one of claims 1 to 4 or a composition according to any one of claims 5 to 7 . 9. A vaccine according to claim 8 , wherein the vaccine is for reducing the susceptibility of birds of the order Galliformes to reovirus-induced viral arthritis/tenosynovitis. avian reovirus strain 94826 C140, deposited with the ATCC under patent designation PTA-126077, or a progeny or derivative thereof, in an amount sufficient to protect birds from reovirus-induced viral arthritis/tenosynovitis; A vaccine for birds of the order Galliformes, comprising a pharmaceutically acceptable carrier. 11. The vaccine according to claim 9 or 10 , wherein the reovirus-induced viral arthritis/tenosynovitis is variant group 1/genotype 5-induced viral arthritis/tenosynovitis. avian reovirus avian reovirus 96139 strain C140, deposited with the ATCC under patent designation PTA-126078, or a progeny thereof, in an amount sufficient to protect birds from reovirus-induced viral arthritis/tenosynovitis; or a derivative thereof and a pharmaceutically acceptable carrier . 13. The vaccine according to claim 11 or 12 , wherein the reovirus-induced viral arthritis/tenosynovitis is mutant group 2/genotype 1-induced viral arthritis/tenosynovitis. comprising the avian reovirus according to any one of claims 1 to 4 , the composition according to any one of claims 5 to 7, or the vaccine according to any one of claims 8 to 13. , effervescent tablets. The avian reovirus according to any one of claims 1 to 4 , the composition according to any one of claims 5 to 7, the vaccine according to any one of claims 8 to 13, or the claim 15. A method for reducing the susceptibility of Galliformes birds to reovirus-induced viral arthritis/tenosynovitis, comprising administering to the bird an effervescent tablet according to item 14 . The avian reovirus according to any one of claims 1 to 4 , the composition according to any one of claims 5 to 7, the vaccine according to any one of claims 8 to 13, or the claim 15. A method for protecting birds of the order Galliformes from reovirus-induced viral arthritis/tenosynovitis, comprising administering to the bird an effervescent tablet according to item 14 . 17. The method of claim 15 or 16 , wherein the administration comprises intranasal, intraocular, oral, mucosal, intramuscular, or subcutaneous administration; in ovo; administration by aerosol; or administration in drinking water . 18. A method according to any one of claims 15 to 17 , wherein the administration comprises administration to a breeding hen or a rooster. An isolated avian reovirus according to any one of claims 1 to 4 , a composition according to any one of claims 5 to 7 or a composition according to any one of claims 8 to 13. 15. A method of producing anti-reovirus antibodies in poultry, comprising administering to the bird a vaccine or an effervescent tablet according to claim 14 . A method according to any one of claims 15 to 19 , wherein the bird is a chicken or a turkey. A diagnostic kit comprising the isolated avian reovirus according to any one of claims 1 to 4. 4. Exposure to avian reovirus in said bird , comprising the step of determining that an antiserum sample obtained from said bird specifically binds to an avian reovirus according to any one of claims 1 to 3. How to detect. A hyperimmune serum against avian reovirus according to any one of claims 1 to 3. An antibody that binds to the avian reovirus according to any one of claims 1 to 3, but does not bind to the avian reovirus S1133, 1733, 2408, and/or 2177 strains.