JPWO2021102447A5 - - Google Patents

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Publication number
JPWO2021102447A5
JPWO2021102447A5 JP2022529897A JP2022529897A JPWO2021102447A5 JP WO2021102447 A5 JPWO2021102447 A5 JP WO2021102447A5 JP 2022529897 A JP2022529897 A JP 2022529897A JP 2022529897 A JP2022529897 A JP 2022529897A JP WO2021102447 A5 JPWO2021102447 A5 JP WO2021102447A5
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Japan
Prior art keywords
currents
electrode
bias current
current
working electrode
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Pending
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JP2022529897A
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Japanese (ja)
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JP2023502507A (en
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Priority claimed from PCT/US2020/062068 external-priority patent/WO2021102447A1/en
Publication of JP2023502507A publication Critical patent/JP2023502507A/en
Publication of JPWO2021102447A5 publication Critical patent/JPWO2021102447A5/ja
Pending legal-status Critical Current

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Claims (20)

組織を電気的に変調させるためのシステムであって、
電流発生器と、
少なくとも１つの植え込み可能な作用電極であって、前記電流発生器と電気的に通信するように構成されている、少なくとも１つの植え込み可能な作用電極と、
少なくとも１つの不関電極と、
コントローラであって、
前記作用電極に送達されるべき１セットの初期極性を有する１セットの電流を発生させるために、
前記電流発生器に信号を送るように構成されているコントローラと
を備え、
前記少なくとも１つの不関電極は、バイアス電流を吸収し、前記バイアス電流は、前記１セットの電流の総和に大きさが等しく、極性が反対であり、
前記１セットの電流は、超低周波電流を含む、システム。 A system for electrically modulating tissue, the system comprising:
a current generator;
at least one implantable working electrode configured to be in electrical communication with the current generator;
at least one indifferent electrode;
A controller,
to generate a set of currents with a set of initial polarities to be delivered to the working electrode;
a controller configured to send a signal to the current generator;
the at least one indifferent electrode absorbs a bias current, the bias current being equal in magnitude and opposite in polarity to the sum of the set of currents;
The system, wherein the set of currents includes very low frequency currents. 前記超低周波電流は、約１Ｈｚよりも小さい、請求項１に記載のシステム。 The system of claim 1, wherein the very low frequency current is less than about 1 Hz. 前記超低周波電流は、約０．１Ｈｚよりも小さい、請求項１に記載のシステム。 The system of claim 1, wherein the very low frequency current is less than about 0.1 Hz. 前記超低周波電流は、約０．０１Ｈｚよりも小さい、請求項１に記載のシステム。 The system of claim 1, wherein the very low frequency current is less than about 0.01 Hz. 組織を電気的に変調させるためのシステムであって、前記システムは、
電流発生器と、
少なくとも１つの植え込み可能な作用電極であって、前記電流発生器と電気的に通信するように構成されている、少なくとも１つの植え込み可能な作用電極と、
少なくとも１つの不関電極と、
コントローラであって、
前記作用電極に送達されるべき１セットの初期極性を有する１セットの電流を発生させるために、
前記電流発生器に信号を送るように構成されているコントローラと
を備え、
前記少なくとも１つの不関電極は、バイアス電流を吸収し、前記バイアス電流は、前記１セットの電流の総和に大きさが等しく、極性が反対である、システム。 A system for electrically modulating tissue, the system comprising:
a current generator;
at least one implantable working electrode configured to be in electrical communication with the current generator;
at least one indifferent electrode;
A controller,
to generate a set of currents with a set of initial polarities to be delivered to the working electrode;
a controller configured to send a signal to the current generator;
The system wherein the at least one indifferent electrode absorbs a bias current, the bias current being equal in magnitude and opposite in polarity to the sum of the set of currents. 前記１セットの電流は、電気的に興奮性の組織を変調させるのに十分である、請求項５に記載のシステム。 6. The system of claim 5, wherein the set of currents is sufficient to modulate electrically excitable tissue. 前記少なくとも１つの植え込み可能な作用電極は、高電荷容量材料を含む、請求項５または６に記載のシステム。 7. The system of claim 5 or 6, wherein the at least one implantable working electrode comprises a high charge capacity material. 前記バイアス電流は、アノード極性で動作する、請求項５または６に記載のシステム。 7. The system of claim 5 or 6, wherein the bias current operates with an anodic polarity. 前記バイアス電流は、カソード極性で動作する、請求項５または６に記載のシステム。 7. The system of claim 5 or 6, wherein the bias current operates with cathodic polarity. 前記１セットの電流は、前記作用電極の電圧をカソード的にバイアスする前記バイアス電流を発生させるように構成されている、請求項５に記載のシステム。 6. The system of claim 5, wherein the set of currents is configured to generate the bias current that cathodically biases the voltage of the working electrode. 前記１セットの電流は、前記作用電極の電圧をアノード的にバイアスする前記バイアス電流を発生させるように構成されている、請求項５に記載のシステム。 6. The system of claim 5, wherein the set of currents is configured to generate the bias current that anodicly biases the voltage of the working electrode. 前記１セットの電流は、前記不関電極の電圧をカソード的にバイアスする前記バイアス電流を発生させるように構成されている、請求項５に記載のシステム。 6. The system of claim 5, wherein the set of currents is configured to generate the bias current that cathodically biases the voltage of the indifferent electrode. 前記１セットの電流は、前記不関電極の電圧をアノード的にバイアスする前記バイアス電流を発生させるように構成されている、請求項５に記載のシステム。 6. The system of claim 5, wherein the set of currents is configured to generate the bias current that anodicly biases the voltage of the indifferent electrode. 少なくとも２つの作用電極を含む、請求項５から１３のいずれか一項に記載のシステム。 14. A system according to any one of claims 5 to 13, comprising at least two working electrodes. 少なくとも１つの作用電極の前記初期極性は、カソードである、請求項５に記載のシステム。 6. The system of claim 5, wherein the initial polarity of at least one working electrode is cathodic. 少なくとも１つの作用電極の前記初期極性は、アノードである、請求項５に記載のシステム。 6. The system of claim 5, wherein the initial polarity of at least one working electrode is anode. 前記不関電極は、皮膚表面電極である、請求項５から１６のいずれか一項に記載のシステム。 17. A system according to any one of claims 5 to 16, wherein the indifferent electrode is a skin surface electrode. 前記不関電極は、経皮的な電極または植え込まれた電極である、請求項５から１７のいずれか一項に記載のシステム。 18. The system of any one of claims 5 to 17, wherein the indifferent electrode is a percutaneous electrode or an implanted electrode. 前記不関電極は、チタンを含む、請求項５から１８のいずれか一項に記載のシステム。 19. A system according to any one of claims 5 to 18, wherein the indifferent electrode comprises titanium. 前記高電荷容量材料は、窒化チタンによってコーティングされたタンタルを含む、請求項５から１９のいずれか一項に記載のシステム。 20. The system of any one of claims 5 to 19 , wherein the high charge capacity material comprises tantalum coated with titanium nitride.
JP2022529897A 2019-11-24 2020-11-24 Current bias as a control mechanism for electrode operation Pending JP2023502507A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962939659P 2019-11-24 2019-11-24
US62/939,659 2019-11-24
PCT/US2020/062068 WO2021102447A1 (en) 2019-11-24 2020-11-24 Current bias as a control mechanism for electrode operation

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JP2023502507A JP2023502507A (en) 2023-01-24
JPWO2021102447A5 true JPWO2021102447A5 (en) 2023-12-04

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US (1) US20230008440A1 (en)
EP (1) EP4061269A4 (en)
JP (1) JP2023502507A (en)
AU (1) AU2020386650A1 (en)
CA (1) CA3159295A1 (en)
WO (1) WO2021102447A1 (en)

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EP3606599A4 (en) 2017-04-03 2021-01-13 Presidio Medical, Inc. Systems and methods for direct current nerve conduction block
CA3091769A1 (en) 2018-02-20 2019-08-29 Presidio Medical, Inc. Methods and systems for nerve conduction block
US11752329B2 (en) 2018-07-01 2023-09-12 Presidio Medical, Inc. Systems and methods for nerve conduction block
EP4061476A4 (en) 2019-11-24 2023-12-13 Presidio Medical, Inc. Pulse generation and stimulation engine systems
US11872397B2 (en) 2020-07-22 2024-01-16 Nexalin Technology, Inc. Transcranial alternating current dynamic frequency stimulation (TACS) system
US11944806B2 (en) * 2020-07-22 2024-04-02 Nexalin Technology, Inc. Transcranial alternating current dynamic frequency stimulation method for anxiety, depression, and insomnia (ADI)
US20220023616A1 (en) * 2020-07-22 2022-01-27 Nexalin Technology, Inc. Alternating current dynamic frequency stimulation system and method for opioid use disorder (oud) and substance use disorder (sud)
WO2022251520A1 (en) * 2021-05-26 2022-12-01 Presidio Medical, Inc. Acute blockade with delayed neural suppression

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EP2038004B1 (en) * 2006-07-05 2018-01-24 Precisis AG System for treatment of neurological disorders via electrical stimulation
JP5443989B2 (en) * 2006-10-18 2014-03-19 ボストン サイエンティフィック ニューロモデュレイション コーポレイション Multi-electrode implantable stimulator with a single current path decoupling capacitor
ES2602989T3 (en) * 2007-07-20 2017-02-23 Boston Scientific Neuromodulation Corporation Stimulation system to control the order of neuronal recruitment and the clinical effect
US9681828B2 (en) * 2014-05-01 2017-06-20 Medtronic Minimed, Inc. Physiological characteristic sensors and methods for forming such sensors
CA3091769A1 (en) * 2018-02-20 2019-08-29 Presidio Medical, Inc. Methods and systems for nerve conduction block

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