JPWO2021050647A5

JPWO2021050647A5 -

Info

Publication number: JPWO2021050647A5
Application number: JP2022516044A
Authority: JP
Publication date: 2023-03-09
Anticipated expiration: 2040-09-10

Claims

a base unit having a power supply and a reservoir for containing cooling fluid;
an applicator connected to the base unit via a cable, the tissue cooling element having an associated channel structure constructed and arranged to engage biological tissue for treatment; an applicator comprising: a light source powered by a power source and constructed and arranged to produce optical energy directed to the tissue cooling element to be directed to the biological tissue;
a first fluid passage between said reservoir and said channel structure of said tissue cooling element for delivering a cooling fluid to said tissue cooling element at a first temperature to cool said biological tissue ; a first fluid passageway through which the fluid is heated to a second temperature in heat exchange with said biological tissue;
a second fluid passageway between the channel structure and the reservoir for returning the cooling fluid to the reservoir, directing the cooling fluid to the light source at the second temperature before being returned to the reservoir; a second fluid passage constructed and arranged to cool the light source ;
with
The first and second fluid passageways define a single cooling fluid circulation loop that sequentially cools both the tissue cooling element and the light source, and a portion of each of the first and second fluid passageways. is a tissue processing system disposed within said cable.

2. The system of Claim 1, wherein said tissue cooling element is a light guide or a transparent window.

2. The system of claim 1, wherein said cooling fluid is water or antifreeze.

2. The system of claim 1, wherein the light source is a flashlamp, a flashlamp and laser rod, or a diode laser.

further comprising a pump for pumping said cooling fluid from said reservoir, and further comprising a heat exchanger constructed and arranged to maintain a temperature of said cooling fluid pumped by said pump near ambient temperature. 2. The system of claim 1.

6. The system of Claim 5, wherein said heat exchanger comprises a radiator.

a pump for pumping the cooling fluid from the reservoir; and a cooling module constructed and arranged to maintain a temperature of the cooling fluid pumped by the pump below ambient temperature. The system of Claim 1.

8. The system of claim 7, wherein said cooling module comprises a thermoelectric cooling module or a compressor chiller system.

2. The system of claim 1, wherein said light source is a diode laser and said second fluid passageway communicates with a channel within said diode laser.

2. The system of claim 1, wherein said light source comprises a flash lamp and a laser rod, said light source being disposed within said cooling fluid bath created by said second fluid passageway.

2. The system of claim 1, further comprising a heat source disposed within said second fluid passage for heating said cooling fluid prior to reaching said light source.

12. The system of Claim 11, wherein the heat source is a heater or radiator.

The channel structure of the tissue cooling element has an inlet, the channel structure extends through the tissue cooling element to an outlet of the channel structure, and the first fluid passageway communicates with the reservoir and the inlet of the channel structure. and said second fluid passageway is between said outlet of said channel structure and said reservoir.

a base unit having a power supply and a reservoir for containing cooling fluid;
an applicator connected to the base unit via a cable, the light source being powered by the power source and constructed and arranged to generate light energy; A light guide positioned adjacent to a light source and constructed and arranged to engage the biological tissue for treatment, and having a cold side and a hot side, the cold side being associated with the light guide. an applicator comprising at least one thermoelectric cooler and at least one hot side plate attached to the hot side of the thermoelectric cooler;
delivering a cooling fluid to the hot side plate to cool the cooling fluid to a first temperature and the cold side of the thermoelectric cooler to cool the light guide and cool the biological tissue; A first fluid passage structure between the reservoir and the high temperature side plate, wherein the cooling fluid is heated to a second temperature by heat exchange with the biological tissue. aisle structure ,
a second fluid passage structure between the hot side plate and the reservoir for returning the cooling fluid to the reservoir, the cooling fluid being returned to the light source at the second temperature before being returned to the reservoir; a second fluid passage structure constructed and arranged to direct and cool the light source ;
with
the first and second fluid passage structures define a single cooling fluid circulation loop that sequentially cools both the light guide and the light source;
A tissue processing system wherein a portion of each of the first and second fluid passageway structures are disposed within the cable.

15. The system of claim 14 , wherein said light guide is a prism.

16. The system of Claim 15 , wherein the cold side of the thermoelectric cooler is attached directly to the prism.

further comprising at least one cold side plate having a first portion attached to the cold side of the thermoelectric cooler and a second portion attached to the prism, the hot side plate being connected to the light source; attached to a part of
The first fluid passage structure is configured to deliver the cooling fluid to the hot side plate to cool the cold side and cold side plates of the thermoelectric cooler, thereby cooling the light guide. 16. The system of claim 15 .

Two pairs of plates and two thermoelectric coolers are provided, each pair of plates comprising a cold side plate and a hot side plate, with one thermoelectric cooler positioned between the associated cold side plate and hot side plate. and wherein the first fluid passage structure connects the reservoir and each hot plate to deliver a cooling fluid to each hot plate to cool each cold plate to cool the light guide. side plates, said second fluid passage structure being disposed between each hot side plate and said reservoir to return said cooling fluid to said reservoir, said second fluid passage structure comprising: 18. The system of claim 17, associated with the light source to direct cooling fluid from each hot side plate to the light source before being returned to the reservoir.

15. The system of claim 14 , wherein said cooling fluid is water or antifreeze.

Two thermoelectric coolers and two hot side plates are provided, and the first fluid passage structure directs cooling fluid to each hot side plate to cool the cold side of each thermoelectric cooler, thereby cooling the light guide. Disposed between the reservoir and each hot side plate for cooling, the second fluid passage structure being disposed between each hot side plate and the reservoir for returning the cooling fluid to the reservoir. 15. The system of claim 14 , wherein said second fluid passage structure is associated with said light source to direct cooling fluid from each hot side plate to said light source before being returned to said reservoir.

1. A method of cooling a tissue processing system, said system comprising a base unit having a power source and a reservoir for containing a cooling fluid, and an applicator connected to said base unit via a cable, comprising: the applicator includes a light source constructed and arranged to generate light energy powered by the power source; a tissue cooling element positioned adjacent to the light source to direct the light energy to living tissue; a portion of the tissue cooling element configured to contact the living tissue;
providing a first fluid passage structure extending from the reservoir in association with the tissue cooling element;
The cooling fluid is delivered at a first temperature through the first fluid passage structure to cool the tissue cooling element to cool the body tissue , and the cooling fluid heat exchanges with the body tissue to a second temperature. allowing to be heated to a temperature of
providing a second fluid passageway structure from the tissue cooling element to the reservoir for returning the cooling fluid to the reservoir, the second fluid passageway structure being associated with the light source;
directing the cooling fluid at the second temperature to the light source through the second fluid passage structure to cool the light source before returning the cooling fluid to the reservoir;
including
the first and second fluid passage structures define a single cooling fluid circulation loop that sequentially cools both the tissue cooling element and the light source;
A portion of each of said first and second fluid passage structures is disposed within said cable.

The tissue cooling element is a transparent window or light guide with a channel structure therethrough, the channel structure separating the first and second channels so that the cooling fluid can flow through the channel structure. 22. The method of Claim 21 in communication with a fluid passageway structure.

the tissue cooling element is a prism-shaped light guide;
At least one thermoelectric cooler having a hot side and a cold side, wherein a hot side plate is coupled to the hot side of the thermoelectric cooler and the cold side of the thermoelectric cooler is associated with the light guide. providing a cooler;
delivering the cooling fluid through the first fluid passage structure to the hot side plate to cool the cold side of the thermoelectric cooler and the light guide to cool the biological tissue;
22. The method of claim 21 , further comprising: