JPWO2021041557A5 - - Google Patents

Claims (27)

A computer readable medium which, when executed, provides the processor with a radiotherapeutic ablation dose to a first region, followed by said ablation dose to a second region by radiotherapy. A computer readable medium configured with instructions for causing a radiation therapy system to apply a sub-ablation dose. 2. The computer-readable medium of claim 1, wherein the sub-ablation dose is given at least one hour after the ablation dose. 2. The computer-readable medium of claim 1, wherein the sub-ablation dose is given at most four days after the ablation dose. 3. The computer-readable medium of claim 1, wherein the cumulative radiotherapeutic dose delivered to the second region over the course of treatment comprises a radiotherapeutic dose that is less than an ablation dose. 5. The computer-readable medium of claim 4, wherein the cumulative dose from radiation therapy that is less than an ablation dose comprises a plurality of sub-ablation doses. 2. The computer-readable medium of claim 1, wherein said first region comprises a region of a tumor and optionally said second region comprises said region of said tumor. 2. The computer-readable medium of claim 1, wherein the first region comprises a region of a first tumor and the second region comprises a region of a second tumor. 8. The computer-readable medium of Claim 7, wherein the first tumor comprises a primary tumor and the second tumor comprises a metastatic tumor. 8. The computer readable medium of Claim 7, wherein the first tumor comprises a metastatic tumor and the second tumor comprises a primary tumor. 8. The computer-readable medium of claim 7, wherein the second region comprises a plurality of second regions, each of the plurality of second regions receiving a cumulative radiation therapy dose that is less than an ablation dose. 2. The computer-readable medium of Claim 1, wherein the second area comprises a different area than the first area. 3. The computer-readable medium of Claim 1, wherein the second region comprises a tumor region. Said second region comprises a region prone to develop metastatic tumors, optionally said second region comprises bone, lymph node, lung, liver, brain, adrenal gland, breast, eye, kidney, muscle, 2. The computer-readable medium of claim 1, comprising a region of an organ selected from the group consisting of pancreas, salivary gland and spleen. 2. The computer-readable medium of claim 1, wherein the second region comprises the entire subject scanned with the sub-ablation dose. The first region is the group consisting of breast, bladder, brain, colon, rectum, endometrium, kidney, pancreas, prostate, liver, lung, skin, thyroid, uterus, lymph nodes, tonsils, thymus, spleen and bone marrow. a region of primary or metastatic tumor of an organ selected from said second region comprising bone, lymph node, lung, liver, brain, adrenal gland, breast, eye, kidney, muscle, pancreas, salivary gland and 2. The computer readable medium of claim 1, comprising a region of metastatic tumor of an organ selected from the group consisting of spleen. said first region comprises a region of metastatic tumor of an organ selected from the group consisting of bone, lymph node, lung, liver, brain, adrenal gland, breast, eye, kidney, muscle, pancreas, salivary gland and spleen; The second region is the group consisting of breast, bladder, brain, colon, rectum, endometrium, kidney, pancreas, prostate, liver, lung, skin, thyroid, uterus, lymph nodes, tonsils, thymus, spleen and bone marrow. 2. The computer readable medium of claim 1, comprising a primary tumor of an organ selected from 2. The computer-readable medium of claim 1, wherein the first region comprises an identified tumor and the second region does not contain an identified tumor. 18. The computer-readable medium of any one of claims 1-17, wherein the ablation dose comprises between 20 Gy and 100 Gy in the first region. The sub-ablation dose comprises between 0.1 Gy and 2 Gy, optionally the sub-ablation dose comprises a plurality of sub-ablation doses, each of the plurality of sub-ablation doses being 0 in the second region. 18. The computer readable medium of any one of claims 1-17 comprising between .1 Gy and 2 Gy. Said sub-ablation dose comprises between 0.1 Gy and 0.5 Gy, optionally said sub-ablation dose comprises a plurality of sub-ablation doses, said plurality of sub-ablation doses each corresponding to said second region. 18. The computer readable medium of any one of claims 1-17, comprising between 0.1 Gy and 5 Gy at. 21. The computer readable medium of any one of claims 1-20, wherein three sub-ablation doses are administered. 21. The computer readable medium of any one of claims 1-20, wherein more than 3 sub-ablation doses are administered. 21. The computer-readable medium of any one of claims 1-20, wherein the first sub-ablation dose is administered within 1 hour to 12 days after administration of the ablation dose. The radiation therapy is the size of the tumor to be treated or 24. The computer readable medium of any one of claims 1-23, which reduces strength. Said radiation therapy increases the survival rate of the subject, reduces the number or severity of symptoms that the subject develops, increases the number of immune cells in the tumor microenvironment, or increases the number of immune cells in the tumor microenvironment. 24. The computer readable medium of any one of claims 1-23, which increases the number of activated immune cells. Radiation is selected from the group consisting of X-ray irradiation, gamma irradiation, alpha particle irradiation, beta particle irradiation, neutron particle irradiation, external beam irradiation and brachytherapy. A computer-readable medium as described. A radiation therapy system, the radiation therapy system comprising:
a radiation source that provides an ablation dose and a sub-ablation dose;
a processor coupled to the radiation source and configured with computer readable medium instructions according to any one of claims 1-26.