JPWO2020254819A5

JPWO2020254819A5 -

Info

Publication number: JPWO2020254819A5
Application number: JP2021574995A
Authority: JP
Publication date: 2023-04-10

Description

図面を具体的に参照すると、図１は、発明の第１の実施形態によるカートリッジの内部作用構成を示す。カートリッジの全体的な外寸は、幅約３８ｍｍ及び長さ約８０ｍｍを有するベース層１１の寸法と同様である。 Referring specifically to the drawings, Figure 1 shows the internal working configuration of a cartridge according to a first embodiment of the invention. The overall outer dimensions of the cartridge are similar to those of the base layer 11, which has a width of approximately 38 mm and a length of approximately 80 mm.

これに分析層１２が積層される。分析層１２は直径約２０ｍｍの凝縮ゾーン１３を含み、凝縮ゾーン１３はその表面の大部分に沿って露出され、使用時にデバイスのマウスピース（不図示）に流体接続されることにより、ユーザからの呼気を受容し、その呼気が凝縮ゾーン１３において流体に凝縮する。凝縮ゾーン１３の表面は、凝縮された呼気がその表面にわたって膜として拡がるようにする親水性材料で形成又は被覆される。第１の実施形態では、その材料は、凝縮流体と当該材料との間の接触角が２０．０°未満、好ましくは５．０～１５．０°となるような親水性を有する。この膜構造は、分析領域が最下部となるようにカートリッジが保持される場合に流体が分析チャンバ１５に向かって凝縮ゾーン１３の縁部に沿って下方に流れるように作用する。 The analysis layer 12 is laminated on this. The analytical layer 12 includes a condensation zone 13 approximately 20 mm in diameter, which is exposed along most of its surface and which in use is fluidly connected to the mouthpiece (not shown) of the device, thereby allowing condensation from the user. It receives exhaled air and condenses it into a fluid in the condensation zone 13 . The surface of the condensation zone 13 is formed or coated with a hydrophilic material that causes the condensed exhaled air to spread over its surface as a film. In a first embodiment, the material has hydrophilicity such that the contact angle between the condensing fluid and the material is less than 20.0°, preferably between 5.0 and 15.0°. This membrane structure acts to force fluid to flow downwards along the edge of the condensation zone 13 towards the analysis chamber 15 when the cartridge is held with the analysis area at the bottom.

図７ａ，７ｂ及び８ａ，８ｂは、カバーシート５０上に固定された最終カバープレート７０を示す。カバープレート７０は、透明材料で形成されることが多く、平坦であり、固定手段を貫通可能とする開口によって固定可能である。カバープレート７０の一方の面は、大部分において、親水性材料によって覆われ、又は一部の実施形態では親水性材料によって形成され、その親水性材料は、それの上に当たって凝縮する呼気に膜を形成させるものである。カバープレート７０は、親水性表面が開口４４、５４及びユーザからの呼気のフローに向くように、上述のカートリッジの他の要素に固定される。 7a, 7b and 8a, 8b show the final cover plate 70 fixed on the cover sheet 50. FIG. The cover plate 70 is often formed of a transparent material, is flat, and is securable by means of apertures that allow a securing means to pass therethrough. One side of the cover plate 70 is, for the most part, covered by, or in some embodiments formed by, a hydrophilic material that forms a membrane on exhaled air that condenses against it. to form. A cover plate 70 is secured to the other elements of the cartridge described above so that the hydrophilic surface faces the openings 44, 54 and the flow of exhaled air from the user.

Claims

A breath condensate analysis cartridge suitable for incorporation into a breath device, comprising:
a condensation zone having a peripheral region and receiving exhaled air;
an analysis chamber in which the sample is analyzed;
with
a surface of the condensation zone acts to create a fluid flow path within the peripheral region;
said condensation zone is connected by a fluid flow path to said analysis chamber through said peripheral region;
The cartridge further comprising a lip at least partially covering said peripheral region, said lip forming a capillary which cooperates with said condensation zone to control fluid flow.

2. The cartridge of claim 1, wherein said condensation zone is circular.

3. The cartridge of claim 2, wherein said condensation zone has a diameter of 15.0-25.0 mm.

4. The cartridge of claim 3, wherein said diameter is 20.0 mm.

5. A cartridge according to any preceding claim, wherein the condensation zone is coated or formed with a hydrophilic material.

6. A cartridge according to any preceding claim, wherein the hydrophilicity of the surface of the condensation zone is selected to form an angle with exhaled breath condensate of less than 20.0[deg.].

A cartridge according to claim 6, wherein said angle is between 5.0° and 15.0°.

6. Any of claims 1 to 5, wherein the analysis chamber includes an air vent and the hydrophilicity of the surface of the condensation zone is selected to form an angle of 23.0° to 35.0° with exhaled breath condensate. or the cartridge according to item 1.

A cartridge according to claim 8, wherein said angle is selected to be between 24.0° and 26.0°.

10. A cartridge according to any one of claims 1 to 9, wherein the lip comprises a narrow strip whose first end is adjacent or continuous with the analysis chamber.

11. A cartridge according to claim 10, wherein the strip has a width of 125-400 μm.

12. A cartridge according to claim 11, wherein said strip has a width of 125-300 μm.

A cartridge according to any one of claims 10 to 12, wherein the distance of said strip from said condensation zone is 125 to 350 µm.

14. A cartridge according to claim 13, wherein said distance is 250-300 μm.

15. A cartridge according to any preceding claim, wherein a portion of said condensation zone is constructed or coated with a hydrophobic material, said portion being located adjacent said analysis chamber and said peripheral region.

16. A cartridge according to any preceding claim, wherein the overall dimensions of the cartridge are those of a conventional credit card.

17. A cartridge according to any one of the preceding claims, wherein the cartridge has a layered structure that helps the cartridge to be bendable.