JPWO2020220046A5 - - Google Patents

Claims (27)

a hydrogel matrix comprising a photoabsorber;
a void architecture in the matrix having a first vascular architecture and a second vascular architecture that are tubular and bifurcated, respectively;
the first and second vascular architectures are fluidly independent from each other;
device. 2. The device of Claim 1, wherein at least 90% of visible light incident on said device is transmitted through said device to allow said device to be imaged. 3. The device of Claim 1, wherein the light absorber is at least partially washed out of the device. 2. The device of Claim 1, wherein the light absorber is degradable independently of any degradation of the remaining hydrogel matrix. 3. The device of claim 1, wherein the light absorber is degradable by chemical or physical processes including photobleaching or boiling . 3. The device of claim 1, wherein the void architecture is a multi-vessel void architecture, further comprising a torus entwined with torus knots. 3. The device of claim 1, wherein one or both of the first vascular architecture and the second vascular architecture are formed from a polyhedral tessellation-based model. 8. The device of claim 7 , wherein the polyhedral tessellation-based model represents a blood vessel or airway . 3. The device of claim 1, wherein the void architecture is a multi-vessel void architecture and further comprising a functional valve. 10. The device of claim 9 , wherein said valve is a bicuspid, tricuspid, unicuspid or Tesla valve. 3. The device of Claim 1, wherein the void architecture is a multi-vessel void architecture, and further comprising a fluidic static mixer. 12. The device of claim 11 , wherein the fluid static mixer has 2-50 fin elements. 11. The device of claim 9 or 10 , wherein the functional valve is positionable anywhere in the multi-vessel void architecture. 3. The device of claim 1, which is monolithic. 2. The device of claim 1, wherein the hydrogel matrix is a photopolymerized hydrogel matrix and/or a biodegradable hydrogel matrix. 11. The device of claim 1, manufactured by additive manufacturing. 3. The device of claim 1, wherein the first vascular architecture and the second vascular architecture are intertwined or the first vascular architecture is covered by the second vascular architecture . 2. The device of claim 1, wherein the hydrogel matrix is porous. 3. The device of claim 1, which is implantable. 3. The device of Claim 1, wherein the light absorber is hydrophilic. Light absorbers include food coloring, tartrazine, sunset yellow FCF (yellow No. 6), brilliant blue FCF (FD&C blue No. 1), indigo carmine (FD&C blue No. 2), fast green FCF (FD&C green No. 3) anthocyanins, Anthocyanidins, Erythrosine (FD&C Red No. 3), Allura Red AC (FD&C Red No. 40), Riboflavin (Vitamin B2, E101, E101a, E106), Ascorbic Acid (Vitamin C), Quinoline Yellow WS, Carmoisine (Azorubine), Ponceau 4R ( E124), Patent Blue V (E131), Green S (E142), Yellow 2G (E107), Orange GGN (E111), Red 2G (E128), caramel color, phenol red, methyl orange, 4-nitrophenol and NADH 21. The device of claim 20 , which is one of sodium salts. 3. The device of Claim 1, wherein the light absorber is hydrophobic. Light Absorbers Curcumin (E100), Turmeric, Alpha Carotene, Beta Carotene, Canthaxanthin (Keto Carotenoids), Cochineal Extract, Paprika, Saffron, Ergocalciferol (Vitamin D2), Cholecalciferol (Vitamin D3), Citrus 23. The device of claim 22 , which is one of Red 2, annatto extract and lycopene. 2. The device of claim 1, comprising three or more vascular architectures fluidly independent from each other and from the first and second vascular architectures. 12. The device of claim 11 , wherein the fluid static mixer comprises a light absorber , tartrazine, or fin elements with a 180[deg.] twist . 12. The device of claim 11 , wherein the fluidic static mixer is manufactured by additive manufacturing. 2. The device of claim 1, further comprising a thickening agent to prevent cell sedimentation, said thickening agent comprising xanthan gum having a concentration ranging from 0.02% to 2% by weight .